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https://www.readbyqxmd.com/read/29243448/obstructive-sleep-apnea-are-we-going-overboard
#1
Nicole Riem
No abstract text is available yet for this article.
December 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29243273/long-term-use-of-continuous-positive-airway-pressure-therapy-in-coronary-artery-disease-patients-with-nonsleepy-obstructive-sleep-apnea
#2
Faith S Luyster, Patrick J Strollo, Erik Thunström, Yüksel Peker
BACKGROUND: Excessive daytime sleepiness is a frequent symptom of obstructive sleep apnea (OSA) and has been proposed as a motivator for adherence to continuous positive airway pressure (CPAP) therapy. However, excessive daytime sleepiness is absent in many patients with coronary artery disease (CAD) and concomitant OSA. We evaluated long-term use of CPAP and predictors of CPAP use in nonsleepy and sleepy OSA patients from a CAD cohort. HYPOTHESIS: Long-term CPAP use is lower in CAD patients with nonsleepy OSA vs sleepy OSA...
December 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29241747/pathophysiology-of-the-metabolic-syndrome
#3
Emma McCracken, Monica Monaghan, Shiva Sreenivasan
The metabolic syndrome-otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and "the deadly quartet"-is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated atherosclerotic cardiovascular disease, hyperuricemia/gout, chronic kidney disease, and obstructive sleep apnea...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29241201/cot-death-history-of-an-iatrogenic-disaster
#4
Michael Obladen
Since antiquity, cot death has been explained as accidental suffocation, overlaying, or smothering. Parents were blamed for neglect or drunkenness. A cage called arcuccio was invented around 1570 to protect the sleeping infant. Up to the 19th century, accidents were registered as natural causes of death. From 1830, accidental suffocation became unacceptable for physicians and legislators, and "natural" explanations for the catastrophe were sought, with parents being consoled rather than blamed. Two assumed causes had serious consequences: thymus hyperplasia was irradiated, causing thyroid cancer, and the concept of central apnea was widely accepted, which led to home monitors and distracted from epidemiological evidence...
December 15, 2017: Neonatology
https://www.readbyqxmd.com/read/29238600/morbidity-and-health-related-quality-of-life-of-patients-accessing-laparoscopic-sleeve-gastrectomy-a-single-centre-cross-sectional-study-in-one-province-of-canada
#5
Laurie K Twells, Shannon Driscoll, Deborah M Gregory, Kendra Lester, John M Fardy, Dave Pace
Background: In Canada, severe obesity (BMI ≥ 35 kg/m2) affects 5% or 1.2 million adults. Bariatric surgery is the only effective treatment for severe obesity, but the demand for publicly funded procedures is high and capacity limited. Little is known in Canada about the types of patients undergoing these procedures, especially laparoscopic sleeve gastrectomy (LSG). The study objective is to examine the socio-demographic profile, morbidity and HRQoL of patients accessing LSG in one Canadian province...
2017: BMC Obesity
https://www.readbyqxmd.com/read/29238576/a-case-of-legionella-pneumonia-caused-by-home-use-of-continuous-positive-airway-pressure
#6
Ruby Schnirman, Nasifa Nur, Alice Bonitati, Gerardo Carino
A 67-year-old woman with morbid obesity and severe obstructive sleep apnea presented to the emergency department with 2 days of productive cough, fever, shortness of breath and loose stools. A chest x-ray showed extensive bilateral infiltrates, and she was quickly intubated for acute hypoxic respiratory failure. A urine legionella antigen test was positive, and she was admitted to the intensive care unit with a diagnosis of severe legionella pneumonia. She improved over the next week with a course of levofloxacin...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29237080/cardiopulmonary-coupling-spectrogram-as-an-ambulatory-clinical-biomarker-of-sleep-stability-and-quality-in-health-sleep-apnea-and-insomnia
#7
Robert Joseph Thomas, Christopher Wood, Matt Travis Bianchi
Study Objectives: Ambulatory tracking of sleep and sleep pathology is rapidly increasing with the introduction of wearable devices. The objective of this study was to evaluate a wearable device which used novel computational analysis of the electrocardiogram (ECG), collected over multiple nights, as a method to track the dynamics of sleep quality in health and disease. Methods: This study used the electrocardiogram as a primary signal, a wearable device, the M1, and an analysis of cardiopulmonary coupling to estimate sleep quality...
December 9, 2017: Sleep
https://www.readbyqxmd.com/read/29236821/the-critical-influence-of-nocturnal-breathing-complaints-on-the-quality-of-sleep-after-stroke-the-pittsburgh-sleep-quality-index-and-stop-bang
#8
Giuliano da Paz Oliveira, Eliana Regina Lottemberg Vago, Gilmar Fernandes do Prado, Fernando Morgadinho Santos Coelho
In stroke patients particularly, many factors, such as sleep-related respiratory disturbances, can impair sleep. Cheap and easy-to-use tools have been created to identify sleep quality and sleep disturbances in patients after stroke. This study described the scores of the sleep apnea screening questionnaire - STOP-BANG - in patients after a stroke, and correlated the findings with sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI). The scores of the STOP-BANG and PSQI were 4.3 ± 1.8 and 76 ± 3...
November 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29236274/outcomes-of-adenotonsillectomy-in-severe-pediatric-obstructive-sleep-apnea
#9
Karim El-Kersh, Rodrigo Cavallazzi, Egambaram Senthilvel
We conducted a retrospective chart review to examine the efficacy of adenotonsillectomy for the treatment of severe obstructive sleep apnea (OSA) in children. Our study population was made up of 85 patients-58 boys and 27 girls, aged 1 to 17 years (mean: 6.9 ± 4.4)-with severe OSA who had undergone adenotonsillectomy and pre- and postoperative attended polysomnography (PSG) over a 4-year period. Severe OSA was defined as an apnea-hypopnea index (AHI) of >10 events per hour of sleep. Patients who had an underlying genetic or craniofacial anomaly were excluded...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29233741/cyclooxygenase-enzyme-activity-does-not-impair-respiratory-motor-plasticity-after-one-night-of-intermittent-hypoxia
#10
Adrianne G Huxtable, Elizabeth Kopp, Brendan J Doughtery, Jyoti J Watters, Gordon S Mitchell
Although inflammation is prevalent in many clinical disorders challenging breathing, we are only beginning to understand the impact of inflammation on neural mechanisms of respiratory control. We recently demonstrated one form of respiratory motor plasticity is extremely sensitive to even mild inflammation induced by a single night (8hours) of intermittent hypoxia (IH-1), mimicking aspects of obstructive sleep apnea. Specifically, phrenic long-term facilitation (pLTF) following moderate acute intermittent hypoxia (AIH) is abolished by IH-1, but restored by high doses of the non-steroidal anti-inflammatory drug, ketoprofen...
December 9, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29233488/obstructive-sleep-apnea-and-cardiovascular-risk-from-evidence-to-experience-in-cardiology
#11
Olga Mediano, Geraldo Lorenzi-Filho, Francisco García-Río
No abstract text is available yet for this article.
December 7, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29232179/adenotonsillectomy-for-obstructive-sleep-apnea-in-children-with-complex-chronic-conditions
#12
Reshma Amin, Theresa Holler, Indra Narang, Sharon L Cushing, Evan J Propst, Suhail Al-Saleh
Objective To estimate the prevalence of persistent obstructive sleep apnea postadenotonsillectomy in children with complex chronic conditions. Study Design A retrospective cohort study. Setting The Hospital for Sick Children Sleep laboratory. Subjects Children ≤18 years of age who had moderate to severe obstructive sleep apnea and had polysomnography pre- and postadenotonsillectomy. Methods Medical and polysomnographic data were reviewed. The prevalence of persistent obstructive sleep apnea postadenotonsillectomy was determined for the following groups: no complex chronic conditions, single-system complex chronic conditions, and multisystem complex chronic conditions...
December 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29231958/medical-issues-in-playing-the-oboe-a-literature-review
#13
REVIEW
Sofia Banzhoff, Maria Del Mar Ropero, Gabriele Menzel, Tatjana Salmen, Manfred Gross, Philipp P Caffier
Playing a musical instrument can affect physical and mental health. A literature review was conducted to determine the prevalence of health problems among oboists, which medical conditions can be caused or exacerbated by playing, whether oboe playing can be a protective factor, and whether recommendations are possible as to who should or should not play the oboe. Searches in 7 databases (Medline, Embase, Cochrane Library, Web of Science, SocIndex, PsyIndex, Psychinfo) yielded a total of 950 studies; after exclusion of duplicates and those not meeting eligibility criteria, 37 articles were selected for final analysis...
December 2017: Medical Problems of Performing Artists
https://www.readbyqxmd.com/read/29231011/-research-progress-of-the-relationship-between-sunds-and-osahs
#14
REVIEW
Y D Wu, L Y Zhang, J D Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome (SAS) is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death...
February 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29230160/whole-exome-sequencing-identifies-a-de-novo-ahdc1-mutation-in-a-colombian-patient-with-xia-gibbs-syndrome
#15
Mary García-Acero, Johanna Acosta
Xia-Gibbs syndrome is an autosomal dominant multisystem developmental disorder characterized by global developmental delay, hypotonia, obstructive sleep apnea, seizures, retrocerebellar cysts, delayed myelination, micrognathia, and mild dysmorphic features. Using whole-exome sequencing, we identified a de novo AHDC1 frameshift mutation c.2030_2030delG (p.G677Afs*52) in a Colombian patient, which was absent in both parents. Furthermore, we summarized the phenotypes of patients reported in the literature.
November 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/29229714/testing-and-treatment-for-obstructive-sleep-apnea-in-canada-funding-models-must-change
#16
Sachin R Pendharkar, Marcus Povitz, Nick Bansback, Charles F P George, Debra Morrison, Najib T Ayas
No abstract text is available yet for this article.
December 11, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29229100/sleep-related-respiratory-events-during-non-invasive-ventilation-of-patients-with-chronic-hypoventilation
#17
Sigurd Aarrestad, Magnus Qvarfort, Anne Louise Kleiven, Elin Tollefsen, Ole Henning Skjønsberg, Jean-Paul Janssens
BACKGROUND: Non-invasive ventilation (NIV) is increasingly used in the treatment of patients with chronic hypercapnic respiratory failure (CRF). Residual sleep related respiratory events under NIV such as obstructive or central apnea/hypopnea (AH), or patient-ventilator asynchrony (PVA), may compromise treatment efficacy and/or comfort. AIMS OF STUDY: 1/to quantify the frequency and describe the types of both AH and PVA in a large group of stable patients with CRF during night-time NIV; 2/to analyze the influence of these events on overnight pulse oximetry and transcutaneous CO2 and 3/to assess interrater agreement in identifying and quantifying AH and PVA...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228525/sleep-apnea-and-idiopathic-leg-edema-a-case-control-study
#18
Reza Shahmirzai, Mohammadreza Firouzifar
Idiopathic leg edema is subject to a lot of debates among physicians. Recently sleep apnea was stated to be the cause. We sought to investigate this matter in a sample of Iranian patients with idiopathic leg edema. In this case-control study, 110 patients were selected based on our inclusion/exclusion criteria and allocated to the case (with idiopathic edema, n=55) and control (without edema, n=55) groups. Sex, age, weight, height, and body mass index (BMI) of all subjects were recorded. We evaluated daytime somnolence of all patients using Epworth sleepiness scale and then calculated Apnea, hypopnea index (AHI) using ResMed ApneaLink and AHI≥15 were considered as sleep apnea...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29228393/quantifying-the-arousal-threshold-using-polysomnography-in-obstructive-sleep-apnea
#19
Scott A Sands, Philip I Terrill, Bradley A Edwards, Luigi Taranto Montemurro, Ali Azarbarzin, Melania Marques, Camila M de Melo, Stephen H Loring, James P Butler, David White, Andrew Wellman
Objectives: Precision medicine for obstructive sleep apnea (OSA) requires non-invasive estimates of each patient's pathophysiological "traits". Here we provide the first, automated technique to quantify the respiratory arousal threshold-defined as the level of ventilatory drive triggering arousal from sleep-using diagnostic polysomnographic signals in patients with OSA. Methods: Ventilatory drive preceding clinically-scored arousals was estimated from polysomnographic studies by fitting a respiratory control model (Terrill P et al...
November 9, 2017: Sleep
https://www.readbyqxmd.com/read/29228345/mechanisms-and-mediators-of-hypertension-induced-by-erythropoietin-and-related-molecules
#20
Rajiv Agarwal
Hypertension is a common but frequently overlooked adverse effect of erythropoietin (EPO) therapy. Underreporting of hypertension with EPO is likely due to either more aggressively managing hypertension through the prescription of antihypertensive drugs or closer attention to dry weight. The purpose and focus of this review is to critically evaluate the mechanisms of EPO-induced hypertension. Preclinical data are considered first, followed by clinical data where available. Mediated by a variety of molecules, there is an imbalance in the vascular tone favoring net vasoconstriction that mediates EPO-induced hypertension...
December 8, 2017: Nephrology, Dialysis, Transplantation
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