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Petiveria alliacea

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https://www.readbyqxmd.com/read/28808377/anti-inflammatory-potential-of-petiveria-alliacea-on-activated-raw264-7-murine-macrophages
#1
Rosa Martha Perez Gutierrez, Carlos Hoyo-Vadillo
BACKGROUND: Defense and protection to multiple harmful stimuli are the inflammation, when is self-amplified and uncontrolled is the basis of the pathogenesis of a wide variety of inflammatory illness. The aim of this study was to evaluate if Petiveria alliacea could attenuate inflammation in a murine model of RAW264 macrophages the involved model and its involved mechanism. MATERIALS AND METHODS: The ethanol extract from P. alliacea was precipitated with water and supernatant was used for this study (PW)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28762858/influence-of-polyvinylpyrrolidone-microcrystalline-cellulose-and-colloidal-silicon-dioxide-on-technological-characteristics-of-a-high-dose-petiveria-alliacea-tablet
#2
Martha-Estrella García-Pérez, Zoe Lemus-Rodríguez, Mario Hung-Arbelo, Marlen Vistel-Vigo
PURPOSE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub used by its immunomodulatory, anticancerogenic and anti-inflammatory properties. This study determined the influence of polyvinylpyrrolidone (PVP), colloidal silicon dioxide (CSD) and microcrystalline cellulose (MC) on the technological characteristic of a high-dose P.alliacea tablet prepared by the wet granulation method. METHODOLOGY: The botanical and pharmacognostic analysis of the plant material was firstly performed, followed by a 2(3) factorial design considering three factors at two levels: a) the binder (PVP) incorporated in formulation at 10 and 15% (w/w); b) the compacting agent (CSD) added at 10 and 15% (w/w) and; c) the diluent (MC) included at 7...
August 1, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28712058/reliance-on-medicinal-plant-therapy-among-cancer-patients-in-jamaica
#3
Kimberley Foster, Novie Younger, William Aiken, Doreen Brady-West, Rupika Delgoda
PURPOSE: Patients' perspective of their treatment regime plays a vital role in its success. Recognizing the high prevalence of medicinal plant usage among Jamaicans at large, we investigated the engagement of such remedies by cancer patients, with the aim of uncovering self-medicating habits, perceptions and details of utilized plants. METHODS: A structured, interviewer-based questionnaire was administered to 100 patients attending the oncology and urology clinics at the University Hospital of the West Indies in Kingston, Jamaica...
July 15, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28621111/antiamoebic-activity-of-petiveria-alliacea-leaves-and-their-main-component-isoarborinol
#4
Lizeth Zavala Ocampo, Eva Aguirre HernÁndez, Nury Pérez HernÁndez, Gildardo Rivera SÁnchez, Laurence A Marchat, Esther Ramírez Moreno
Petiveria alliacea L. (Phytolacaceae) is a medicinal plant with a broad range of traditional therapeutic properties, including the treatment of dysentery and intestinal infections caused by protozoan parasites. However its effects against Entamoeba histolytica have not been reported yet. We here investigated the antiamoebic activity present in the leaves of P. alliacea L. Antiamoebic activity was evaluated in methanolic and aqueous extract, as well as in the hexanic, methanolic and EtOAc fractions. P. alliacea L...
June 16, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28344031/culture-bound-syndromes-of-a-brazilian-amazon-riverine-population-tentative-correspondence-between-traditional-and-conventional-medicine-terms-and-possible-ethnopharmacological-implications
#5
E Pagani, J de F L Santos, E Rodrigues
ETHNOPHARMACOLOGICAL RELEVANCE: It is not always possible to correlate the "emic" terms to the "etic" ones during ethnopharmacological surveys, especially regarding those related to Culture-Bound Syndromes (CBS). Nevertheless, it is the role of ethnopharmacology to address these correlations, since they are the basis for the understanding of potential bioactives. AIM AND OBJECTIVES: This study reports the clinical manifestations and therapeutic resources used for the treatment of CBS among some riverine inhabitants of Brazilian Amazonia...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27692312/synergistic-action-of-fatty-acids-sulphides-and-stilbene-against-acaricide-resistant-rhipicephalus-microplus-ticks
#6
G N Arceo-Medina, J A Rosado-Aguilar, R I Rodríguez-Vivas, R Borges-Argaez
Six compounds in a methanolic extract of Petiveria alliacea stem (cis-stilbene; benzyl disulphide; benzyl trisulphide; and methyl esters of hexadecanoic acid, octadecadienoic acid and octadecenoic acid) are known to exercise acaricide activity against cattle tick Rhipicephalus microplus larvae and adults. The synergistic effect of 57 combinations of these six compounds on acaricide activity against R. microplus was evaluated. Larvae immersion tests produced the lethal concentrations needed to kill 50% (LC50) and 99% (LC99) of the population...
September 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27105957/significant-inhibitory-impact-of-dibenzyl-trisulfide-and-extracts-of-petiveria-alliacea-on-the-activities-of-major-drug-metabolizing-enzymes-in-vitro-an-assessment-of-the-potential-for-medicinal-plant-drug-interactions
#7
J Murray, D Picking, A Lamm, J McKenzie, S Hartley, C Watson, L Williams, H Lowe, R Delgoda
Dibenzyl trisulfide (DTS) is the major active ingredient expressed in Petiveria alliacea L., a shrub widely used for a range of conditions, such as, arthritis, asthma and cancer. Given its use alone and concomitantly with prescription medicines, we undertook to investigate its impact on the activities of important drug metabolizing enzymes, the cytochromes P450 (CYP), a key family of enzymes involved in many adverse drug reactions. DTS and seven standardized extracts from the plant were assessed for their impact on the activities of CYPs 1A2, 2C19, 2C9, 2D6 and 3A4 on a fluorometric assay...
June 2016: Fitoterapia
https://www.readbyqxmd.com/read/26944236/ethnobotany-phytochemistry-and-neuropharmacological-effects-of-petiveria-alliacea-l-phytolaccaceae-a-review
#8
REVIEW
Diandra Araújo Luz, Alana Miranda Pinheiro, Mallone Lopes Silva, Marta Chagas Monteiro, Rui Daniel Prediger, Cristiane Socorro Ferraz Maia, Enéas Andrade Fontes-Júnior
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon forest, Central America, Caribbean islands and Mexico, as well as specific regions of Africa. Popularly known by several different names including 'mucuracaá', 'guiné' and 'pipi', P. alliacea has been used in traditional medicine for the treatment of various central nervous system (CNS) disorders, such as anxiety, pain, memory deficits and seizures, as well as for its anaesthetic and sedative properties...
June 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26785289/chemical-inhibition-of-kynureninase-reduces-pseudomonas-aeruginosa-quorum-sensing-and-virulence-factor-expression
#9
Stephen H Kasper, Richard P Bonocora, Joseph T Wade, Rabi Ann Musah, Nathaniel C Cady
The opportunistic pathogen Pseudomonas aeruginosa utilizes multiple quorum sensing (QS) pathways to coordinate an arsenal of virulence factors. We previously identified several cysteine-based compounds inspired by natural products from the plant Petiveria alliacea which are capable of antagonizing multiple QS circuits as well as reducing P. aeruginosa biofilm formation. To understand the global effects of such compounds on virulence factor production and elucidate their mechanism of action, RNA-seq transcriptomic analysis was performed on P...
April 15, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/25895883/petiveria-alliacea-exerts-mnemonic-and-learning-effects-on-rats
#10
Mallone Lopes Silva, Diandra Araújo Luz, Thiago Portal da Paixão, João Paulo Bastos Silva, Ivaldo Jesus Almeida Belém-Filho, Luanna Melo Pereira Fernandes, Ana Cristina Baetas Gonçalves, Enéas Andrade Fontes-Júnior, Marciene Ataíde de Andrade, Cristiane Socorro Ferraz Maia
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub native to the Amazon region and other tropical areas such as Central America and the Caribbean. Popularly known as mucuracaá, P. alliacea is used in the folk medicine for a broad variety of therapeutic purpose and also in religious ceremonies by slaves as a sedative, which highlights its properties on the Central Nervous System (CNS). AIM OF THE STUDY: The present study evaluated the effects of the P...
July 1, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25081571/s-aryl-l-cysteine-sulphoxides-and-related-organosulphur-compounds-alter-oral-biofilm-development-and-ai-2-based-cell-cell-communication
#11
S H Kasper, D Samarian, A P Jadhav, A H Rickard, R A Musah, N C Cady
AIMS: To design and synthesize a library of structurally related, small molecules related to homologues of compounds produced by the plant Petiveria alliacea and determine their ability to interfere with AI-2 cell-cell communication and biofilm formation by oral bacteria. Many human diseases are associated with persistent bacterial biofilms. Oral biofilms (dental plaque) are problematic as they are often associated with tooth decay, periodontal disease and systemic disorders such as heart disease and diabetes...
November 2014: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/25014851/evaluation-of-the-hypoglycaemic-activity-of-petiveria-alliacea-guinea-hen-weed-extracts-in-normoglycaemic-and-diabetic-rat-models
#12
S-L Christie, A Levy
OBJECTIVE: Petiveria alliacea (P alliacea) has ethno-traditional use as a hypoglycaemic agent in Jamaica and is yet to be scientifically validated as such. Therefore, extracts of aerial parts of the plant were evaluated for hypoglycaemic activity in normoglycaemic and diabetic rats. METHOD: Aqueous and hexane extracts prepared from leaves of P alliacea were tested for hypoglycaemic activity. An acute administration of the extracts (200 and 400 mg/kg body weight) was evaluated in normoglycaemic rats...
November 2013: West Indian Medical Journal
https://www.readbyqxmd.com/read/24692692/specific-rsk-kinase-inhibition-by-dibenzyl-trisulfide-and-implication-for-therapeutic-treatment-of-cancer
#13
Henry I C Lowe, Caroline O B Facey, Ngeh J Toyang, Joseph L Bryant
BACKGROUND/AIM: The Jamaican "Guinea Hen Weed" (Petiveria alliacea L.) plant has been traditionally used in folklore medicine to treat a variety of diseases including cancer. In the present study we investigated on the therapeutic feasibility of dibenzyl trisulfide (DTS) (isolated from the Jamaican Guinea Hen Weed) as a potent small-molecule kinase inhibitor to treat cancer. MATERIALS AND METHODS: We investigated the inhibitory effects of DTS against a large panel of kinases using a well-established competitive binding assay...
April 2014: Anticancer Research
https://www.readbyqxmd.com/read/24637191/a-petiveria-alliacea-standardized-fraction-induces-breast-adenocarcinoma-cell-death-by-modulating-glycolytic-metabolism
#14
John Fredy Hernández, Claudia Patricia Urueña, Maria Claudia Cifuentes, Tito Alejandro Sandoval, Luis Miguel Pombo, Diana Castañeda, Alexzander Asea, Susana Fiorentino
ETHNOPHARMACOLOGICAL RELEVANCE: Folk medicine uses aqueous and alcoholic extracts from Petiveria alliacea (Phytolaccaceae) in leukemia and breast cancer treatment in the Caribbean, Central and South America. Herein, we validated the biological activity of a Petiveria alliacea fraction using a metastatic breast adenocarcinoma model (4T1). MATERIALS AND METHODS: Petiveria alliacea fraction biological activity was determined estimating cell proliferation, cell colony growth capacity and apoptosis (caspase-3 activity, DNA fragmentation and mitochondrial membrane potential) in 4T1 cells...
May 14, 2014: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/23198140/traditional-herbal-management-of-sickle-cell-anemia-lessons-from-nigeria
#15
Sunday J Ameh, Florence D Tarfa, Benjamin U Ebeshi
Background. Patients in West Africa where sickle cell anemia (SCA) is endemic have for ages been treated with natural products, especially herbs, as, is still the case in rural communities. Objective. In this paper we look closely at some of these herbs to see if there are any lessons to be learnt or clues to be found for optimizing the treatments based on them, as had been done in the case of NIPRISAN, which was developed from herbs in Nigeria based on Yoruba Medicine. Methods. Select publications on SCA, its molecular biology and pathology, and actual and experimental cases of herbal treatment were perused in search of molecular clues that can be linked to chemical constituents of the herbs involved...
2012: Anemia
https://www.readbyqxmd.com/read/22890225/potential-behavioral-and-pro-oxidant-effects-of-petiveria-alliacea-l-extract-in-adult-rats
#16
Thaís Montenegro de Andrade, Ademar Soares de Melo, Rui Guilherme Cardoso Dias, Everton Luís Pompeu Varela, Fábio Rodrigues de Oliveira, José Luís Fernandes Vieira, Marcieni Ataíde de Andrade, Ana Cristina Baetas, Marta Chagas Monteiro, Cristiane do Socorro Ferraz Maia
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea (Phytolaccaceae) is a perennial shrub indigenous to the Amazon Rainforest and tropical areas of Central and South America, the Caribbean, and sub-Saharan Africa. In folk medicine, Petiveria alliacea has a broad range of therapeutic properties; however, it is also associated with toxic effects. AIM OF THE STUDY: The present study evaluated the putative effects of Petiveria alliacea on the central nervous system, including locomotor activity, anxiety, depression-like behavior, and memory, and oxidative stress...
September 28, 2012: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/22809035/immunomodulatory-effects-of-aqueous-and-organic-fractions-from-petiveria-alliacea-on-human-dendritic-cells
#17
Sandra Paola Santander, John Fredy Hernández, Claudia Cifuentes Barreto, Claudia Cifuentes B, Aoki Masayuki, Aoki M, Hélène Moins-Teisserenc, Moins-Teisserenc H, Susana Fiorentino
Petiveria alliacea is a plant traditionally known for its anti-inflammatory and anti-tumor activities; however, the molecular and cellular mechanisms of its immunomodulatory properties are still unknown. Dendritic cells (DC) promote adaptive immune response by activating T lymphocytes, inducing an effector response or tolerance depending on the DC differentiation level. Herein, we evaluated the immunomodulatory activity of aqueous and organic plant fractions from P. alliacea using human monocyte-derived dendritic cells...
2012: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/21840558/first-insights-into-the-mode-of-action-of-a-lachrymatory-factor-synthase-implications-for-the-mechanism-of-lachrymator-formation-in-petiveria-alliacea-allium-cepa-and-nectaroscordum-species
#18
Quan He, Roman Kubec, Abhijit P Jadhav, Rabi A Musah
A study of an enzyme that reacts with the sulfenic acid produced by the alliinase in Petiveria alliacea L. (Phytolaccaceae) to yield the P. alliacea lachrymator (phenylmethanethial S-oxide) showed the protein to be a dehydrogenase. It functions by abstracting hydride from sulfenic acids of appropriate structure to form their corresponding sulfines. Successful hydride abstraction is dependent upon the presence of a benzyl group on the sulfur to stabilize the intermediate formed on abstraction of hydride. This dehydrogenase activity contrasts with that of the lachrymatory factor synthase (LFS) found in onion, which catalyzes the rearrangement of 1-propenesulfenic acid to (Z)-propanethial S-oxide, the onion lachrymator...
November 2011: Phytochemistry
https://www.readbyqxmd.com/read/20627119/in-vitro-erythrocytic-membrane-effects-of-dibenzyl-trisulfide-a-secondary-metabolite-of-petiveria-alliacea
#19
D J Pepple, A A Richards, D A Lowe, W A Reid, N O Younger, L A D Williams
We investigated the in vitro effect of dibenzyl trisulfide (DTS), a secondary metabolite of Petiveria alliacea, on erythrocyte elasticity, relaxation time and membrane morphology. Blood samples from 8 volunteers with hemoglobin AA were exposed to 100, 200, 400, 800 and 1000 ng/ml of DTS respectively and the elasticity and relaxation time measured. There were statistically significant, dose-dependent increases in elasticity and relaxation times. The changes in membrane morphology observed also increased with increased concentration of DTS...
December 2010: Fitoterapia
https://www.readbyqxmd.com/read/20441056/implications-of-dibenzyl-trisulphide-for-disease-treatment-based-on-its-mode-of-action
#20
L A D Williams, E N Barton, W Kraus, H Rösner
Studies conducted on the secondary metabolite (natural product), dibenzyl trisulphide (DTS), which was isolated from the sub-tropical shrub Petiveria alliacea (guinea hen weed, anamu) [Phytolaccaceae] have shown tremendous pharmaceutical promise as a drug prototype. This is now reflected in the development of the broad spectrum anti-cancer molecule, fluorapacin (bis(4-fluorobenzyl) trisulphide) which has an excellent safety profile. The mode of action elucidated for DTS is the mitogen activated protein extracellular regulated kinases 1 and 2 (MAPKinases ERK 1 and ERK 2)...
November 2009: West Indian Medical Journal
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