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Petiveria alliacea

G N Arceo-Medina, J A Rosado-Aguilar, R I Rodríguez-Vivas, R Borges-Argaez
Six compounds in a methanolic extract of Petiveria alliacea stem (cis-stilbene; benzyl disulphide; benzyl trisulphide; and methyl esters of hexadecanoic acid, octadecadienoic acid and octadecenoic acid) are known to exercise acaricide activity against cattle tick Rhipicephalus microplus larvae and adults. The synergistic effect of 57 combinations of these six compounds on acaricide activity against R. microplus was evaluated. Larvae immersion tests produced the lethal concentrations needed to kill 50% (LC50) and 99% (LC99) of the population...
September 15, 2016: Veterinary Parasitology
J Murray, D Picking, A Lamm, J McKenzie, S Hartley, C Watson, L Williams, H Lowe, R Delgoda
Dibenzyl trisulfide (DTS) is the major active ingredient expressed in Petiveria alliacea L., a shrub widely used for a range of conditions, such as, arthritis, asthma and cancer. Given its use alone and concomitantly with prescription medicines, we undertook to investigate its impact on the activities of important drug metabolizing enzymes, the cytochromes P450 (CYP), a key family of enzymes involved in many adverse drug reactions. DTS and seven standardized extracts from the plant were assessed for their impact on the activities of CYPs 1A2, 2C19, 2C9, 2D6 and 3A4 on a fluorometric assay...
June 2016: Fitoterapia
Diandra Araújo Luz, Alana Miranda Pinheiro, Mallone Lopes Silva, Marta Chagas Monteiro, Rui Daniel Prediger, Cristiane Socorro Ferraz Maia, Enéas Andrade Fontes-Júnior
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon forest, Central America, Caribbean islands and Mexico, as well as specific regions of Africa. Popularly known by several different names including 'mucuracaá', 'guiné' and 'pipi', P. alliacea has been used in traditional medicine for the treatment of various central nervous system (CNS) disorders, such as anxiety, pain, memory deficits and seizures, as well as for its anaesthetic and sedative properties...
June 5, 2016: Journal of Ethnopharmacology
Stephen H Kasper, Richard P Bonocora, Joseph T Wade, Rabi Ann Musah, Nathaniel C Cady
The opportunistic pathogen Pseudomonas aeruginosa utilizes multiple quorum sensing (QS) pathways to coordinate an arsenal of virulence factors. We previously identified several cysteine-based compounds inspired by natural products from the plant Petiveria alliacea which are capable of antagonizing multiple QS circuits as well as reducing P. aeruginosa biofilm formation. To understand the global effects of such compounds on virulence factor production and elucidate their mechanism of action, RNA-seq transcriptomic analysis was performed on P...
April 15, 2016: ACS Chemical Biology
Mallone Lopes Silva, Diandra Araújo Luz, Thiago Portal da Paixão, João Paulo Bastos Silva, Ivaldo Jesus Almeida Belém-Filho, Luanna Melo Pereira Fernandes, Ana Cristina Baetas Gonçalves, Enéas Andrade Fontes-Júnior, Marciene Ataíde de Andrade, Cristiane Socorro Ferraz Maia
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub native to the Amazon region and other tropical areas such as Central America and the Caribbean. Popularly known as mucuracaá, P. alliacea is used in the folk medicine for a broad variety of therapeutic purpose and also in religious ceremonies by slaves as a sedative, which highlights its properties on the Central Nervous System (CNS). AIM OF THE STUDY: The present study evaluated the effects of the P...
July 1, 2015: Journal of Ethnopharmacology
S H Kasper, D Samarian, A P Jadhav, A H Rickard, R A Musah, N C Cady
AIMS: To design and synthesize a library of structurally related, small molecules related to homologues of compounds produced by the plant Petiveria alliacea and determine their ability to interfere with AI-2 cell-cell communication and biofilm formation by oral bacteria. Many human diseases are associated with persistent bacterial biofilms. Oral biofilms (dental plaque) are problematic as they are often associated with tooth decay, periodontal disease and systemic disorders such as heart disease and diabetes...
November 2014: Journal of Applied Microbiology
S-L Christie, A Levy
OBJECTIVE: Petiveria alliacea (P alliacea) has ethno-traditional use as a hypoglycaemic agent in Jamaica and is yet to be scientifically validated as such. Therefore, extracts of aerial parts of the plant were evaluated for hypoglycaemic activity in normoglycaemic and diabetic rats. METHOD: Aqueous and hexane extracts prepared from leaves of P alliacea were tested for hypoglycaemic activity. An acute administration of the extracts (200 and 400 mg/kg body weight) was evaluated in normoglycaemic rats...
November 2013: West Indian Medical Journal
Henry I C Lowe, Caroline O B Facey, Ngeh J Toyang, Joseph L Bryant
BACKGROUND/AIM: The Jamaican "Guinea Hen Weed" (Petiveria alliacea L.) plant has been traditionally used in folklore medicine to treat a variety of diseases including cancer. In the present study we investigated on the therapeutic feasibility of dibenzyl trisulfide (DTS) (isolated from the Jamaican Guinea Hen Weed) as a potent small-molecule kinase inhibitor to treat cancer. MATERIALS AND METHODS: We investigated the inhibitory effects of DTS against a large panel of kinases using a well-established competitive binding assay...
April 2014: Anticancer Research
John Fredy Hernández, Claudia Patricia Urueña, Maria Claudia Cifuentes, Tito Alejandro Sandoval, Luis Miguel Pombo, Diana Castañeda, Alexzander Asea, Susana Fiorentino
ETHNOPHARMACOLOGICAL RELEVANCE: Folk medicine uses aqueous and alcoholic extracts from Petiveria alliacea (Phytolaccaceae) in leukemia and breast cancer treatment in the Caribbean, Central and South America. Herein, we validated the biological activity of a Petiveria alliacea fraction using a metastatic breast adenocarcinoma model (4T1). MATERIALS AND METHODS: Petiveria alliacea fraction biological activity was determined estimating cell proliferation, cell colony growth capacity and apoptosis (caspase-3 activity, DNA fragmentation and mitochondrial membrane potential) in 4T1 cells...
May 14, 2014: Journal of Ethnopharmacology
Sunday J Ameh, Florence D Tarfa, Benjamin U Ebeshi
Background. Patients in West Africa where sickle cell anemia (SCA) is endemic have for ages been treated with natural products, especially herbs, as, is still the case in rural communities. Objective. In this paper we look closely at some of these herbs to see if there are any lessons to be learnt or clues to be found for optimizing the treatments based on them, as had been done in the case of NIPRISAN, which was developed from herbs in Nigeria based on Yoruba Medicine. Methods. Select publications on SCA, its molecular biology and pathology, and actual and experimental cases of herbal treatment were perused in search of molecular clues that can be linked to chemical constituents of the herbs involved...
2012: Anemia
Thaís Montenegro de Andrade, Ademar Soares de Melo, Rui Guilherme Cardoso Dias, Everton Luís Pompeu Varela, Fábio Rodrigues de Oliveira, José Luís Fernandes Vieira, Marcieni Ataíde de Andrade, Ana Cristina Baetas, Marta Chagas Monteiro, Cristiane do Socorro Ferraz Maia
ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea (Phytolaccaceae) is a perennial shrub indigenous to the Amazon Rainforest and tropical areas of Central and South America, the Caribbean, and sub-Saharan Africa. In folk medicine, Petiveria alliacea has a broad range of therapeutic properties; however, it is also associated with toxic effects. AIM OF THE STUDY: The present study evaluated the putative effects of Petiveria alliacea on the central nervous system, including locomotor activity, anxiety, depression-like behavior, and memory, and oxidative stress...
September 28, 2012: Journal of Ethnopharmacology
Sandra Paola Santander, John Fredy Hernández, Claudia Cifuentes Barreto, Claudia Cifuentes B, Aoki Masayuki, Aoki M, Hélène Moins-Teisserenc, Moins-Teisserenc H, Susana Fiorentino
Petiveria alliacea is a plant traditionally known for its anti-inflammatory and anti-tumor activities; however, the molecular and cellular mechanisms of its immunomodulatory properties are still unknown. Dendritic cells (DC) promote adaptive immune response by activating T lymphocytes, inducing an effector response or tolerance depending on the DC differentiation level. Herein, we evaluated the immunomodulatory activity of aqueous and organic plant fractions from P. alliacea using human monocyte-derived dendritic cells...
2012: American Journal of Chinese Medicine
Quan He, Roman Kubec, Abhijit P Jadhav, Rabi A Musah
A study of an enzyme that reacts with the sulfenic acid produced by the alliinase in Petiveria alliacea L. (Phytolaccaceae) to yield the P. alliacea lachrymator (phenylmethanethial S-oxide) showed the protein to be a dehydrogenase. It functions by abstracting hydride from sulfenic acids of appropriate structure to form their corresponding sulfines. Successful hydride abstraction is dependent upon the presence of a benzyl group on the sulfur to stabilize the intermediate formed on abstraction of hydride. This dehydrogenase activity contrasts with that of the lachrymatory factor synthase (LFS) found in onion, which catalyzes the rearrangement of 1-propenesulfenic acid to (Z)-propanethial S-oxide, the onion lachrymator...
November 2011: Phytochemistry
D J Pepple, A A Richards, D A Lowe, W A Reid, N O Younger, L A D Williams
We investigated the in vitro effect of dibenzyl trisulfide (DTS), a secondary metabolite of Petiveria alliacea, on erythrocyte elasticity, relaxation time and membrane morphology. Blood samples from 8 volunteers with hemoglobin AA were exposed to 100, 200, 400, 800 and 1000 ng/ml of DTS respectively and the elasticity and relaxation time measured. There were statistically significant, dose-dependent increases in elasticity and relaxation times. The changes in membrane morphology observed also increased with increased concentration of DTS...
December 2010: Fitoterapia
L A D Williams, E N Barton, W Kraus, H Rösner
Studies conducted on the secondary metabolite (natural product), dibenzyl trisulphide (DTS), which was isolated from the sub-tropical shrub Petiveria alliacea (guinea hen weed, anamu) [Phytolaccaceae] have shown tremendous pharmaceutical promise as a drug prototype. This is now reflected in the development of the broad spectrum anti-cancer molecule, fluorapacin (bis(4-fluorobenzyl) trisulphide) which has an excellent safety profile. The mode of action elucidated for DTS is the mitogen activated protein extracellular regulated kinases 1 and 2 (MAPKinases ERK 1 and ERK 2)...
November 2009: West Indian Medical Journal
Andressa Blainski, Vanessa K Piccolo, João Carlos P Mello, Rúbia M W de Oliveira
AIM OF THE STUDY: Different preparations obtained from P. alliacea have been traditionally used in South America and Brazil for many medical conditions. To investigate the effects of fresh whole plant (WP) extract, aerial part (AP) extract, and root (R) extract obtained from Petiveria alliacea using the elevated plus maze (EPM) model of anxiety in mice. Total flavonoid content present in Petiveria alliacea extracts was also determined. MATERIALS AND METHODS: WP, AP, or R (300-900 mg/kg) extracts were orally administered to mice 30 min before they were subjected to the EPM and open field test...
March 24, 2010: Journal of Ethnopharmacology
Roman Kubec, Robert B Cody, A John Dane, Rabi A Musah, Jan Schraml, Abith Vattekkatte, Eric Block
Lachrymatory (Z)-butanethial S-oxide along with several 1-butenyl thiosulfinates was detected by DART mass spectrometry upon cutting Allium siculum , a popular ornamental Allium species used in some cultures as a spice. (Z)-Butanethial S-oxide isolated from the plant was shown to be identical to a synthetic sample. Its likely precursor, (R(S),R(C),E)-S-(1-butenyl)cysteine S-oxide (homoisoalliin), was isolated from homogenates of A. siculum, and a closely related species Allium tripedale , and fully characterized...
January 27, 2010: Journal of Agricultural and Food Chemistry
J A Rosado-Aguilar, A Aguilar-Caballero, R I Rodriguez-Vivas, R Borges-Argaez, Z Garcia-Vazquez, M Mendez-Gonzalez
The acaricidal activity of crude extracts and fractions from stems and leaves of Petiveria alliacea (Phytolaccaceae) was carried out on larvae and adults of the cattle tick Rhipicephalus (Boophilus) microplus using the larval immersion test (LIT) and adult immersion test (AIT), respectively. Methanolic extracts of stems and leaves of P. alliacea showed 100% mortality on the LIT bioassay. On the other hand, methanolic extracts of leaves and stem on the AIT test showed 26% and 86% of mortality, respectively, egg laying inhibition of 40% and 91%, respectively and hatchability inhibition of 26% and 17%, respectively...
March 25, 2010: Veterinary Parasitology
Rabi A Musah, Quan He, Roman Kubec, Abhijit Jadhav
A novel alliinase (EC was detected and purified from the roots of the Amazonian medicinal plant Petiveria alliacea. The isolated enzyme is a heteropentameric glycoprotein composed of two alpha-subunits (68.1 kD each), one beta-subunit (56.0 kD), one gamma-subunit (24.8 kD), and one delta-subunit (13.9 kD). The two alpha-subunits are connected by a disulfide bridge, and both alpha- and beta-subunits are glycosylated. The enzyme has an isoelectric point of 4.78 and pH and temperature optima of 8.0 and approximately 52 degrees C, respectively...
November 2009: Plant Physiology
Rabi A Musah, Quan He, Roman Kubec
A novel lachrymatory factor synthase (LFS) was isolated and purified from the roots of the Amazonian medicinal plant Petiveria alliacea. The enzyme is a heterotetrameric glycoprotein comprised of two alpha-subunits (68.8 kD each), one gamma-subunit (22.5 kD), and one delta-subunit (11.9 kD). The two alpha-subunits are glycosylated and connected by a disulfide bridge. The LFS has an isoelectric point of 5.2. It catalyzes the formation of a sulfine lachrymator, (Z)-phenylmethanethial S-oxide, only in the presence of P...
November 2009: Plant Physiology
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