Bruna B F Cal, Luana B N Araújo, Brenno M Nunes, Claudia R da Silva, Marcia B N Oliveira, Bianka O Soares, Alvaro A C Leitão, Marcelo de Pádula, Debora Nascimento, Douglas S A Chaves, Rachel F Gagliardi, Flavio J S Dantas
Petiveria alliacea L. is a plant used in traditional medicine harboring pharmacological properties with anti-inflammatory, antinociceptive, hypoglycemiant and anesthetic activities. This study assessed the potential cytotoxic, genotoxic and mutagenic effects of ethanolic extract of P. alliacea on Saccharomyces cerevisiae strains. S. cerevisiae FF18733 (wild type) and CD138 ( ogg1 ) strains were exposed to fractioned ethanolic extracts of P. alliacea in different concentrations. Three experimental assays were performed: cellular inactivation, mutagenesis (canavanine resistance system) and loss of mitochondrial function (petites colonies)...
November 27, 2022: Plants (Basel, Switzerland)