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Ischemic stroke biomarkers in blood

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https://www.readbyqxmd.com/read/29679162/circulating-troponin-i-level-in-patients-with-acute-ischemic-stroke
#1
REVIEW
Jacob VanHouten, Gregory Fricker, Bridget Collins, Ritwik Bhatia, Christopher Ellis, Matthew Schrag
PURPOSE OF REVIEW: Cardiac troponin levels in the blood are an important biomarker of acute coronary events, but may also be elevated in the context of acute ischemic stroke without an obvious concurrent myocardial insult. The objective of this study and systematic review is to determine how high the circulating troponin I level can rise due to ischemic stroke. RECENT FINDINGS: Anonymized medical records from Vanderbilt University Medical Center were reviewed identifying 151,972 unique acute ischemic stroke events, of which 1226 met criteria for inclusion in this study...
April 20, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29668333/blood-biomarkers-in-ischemic-stroke-potential-role-and-challenges-in-clinical-practice-and-research
#2
Konstantinos Makris, Alexander Haliassos, Maria Chondrogianni, Georgios Tsivgoulis
Fast and accurate diagnosis of stroke is crucial for the immediate application of the right therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke cannot be identified based only on clinical assessment. CT or MRI imaging is required to rule out hemorrhagic stroke since thrombolytic therapy can lead to increased intracranial bleeding and further aggravation of hemorrhagic stroke. In addition, clinical situations that imitate the signs and symptoms of stroke may also impede the rapid diagnosis and treatment of stroke victims...
April 18, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29663285/exosomes-in-acquired-neurological-disorders-new-insights-into-pathophysiology-and-treatment
#3
REVIEW
Nicole Osier, Vida Motamedi, Katie Edwards, Ava Puccio, Ramon Diaz-Arrastia, Kimbra Kenney, Jessica Gill
Exosomes are endogenous nanovesicles that play critical roles in intercellular signaling by conveying functional genetic information and proteins between cells. Exosomes readily cross the blood-brain barrier and have promise as therapeutic delivery vehicles that have the potential to specifically deliver molecules to the central nervous system (CNS). This unique feature also makes exosomes attractive as biomarkers in diagnostics, prognostics, and therapeutics in the context of multiple significant public health conditions, including acquired neurological disorders...
April 16, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29655461/metabolomics-and-lipidomics-of-ischemic-stroke
#4
Anthony Au
Ischemic stroke is a sudden loss of brain function due to the reduction of blood flow. Brain tissues cease to function with subsequent activation of the ischemic cascade. Metabolomics and lipidomics are modern disciplines that characterize the metabolites and lipid components of a biological system, respectively. Because the pathogenesis of ischemic stroke is heterogeneous and multifactorial, it is crucial to establish comprehensive metabolomic and lipidomic approaches to elucidate these alterations in this disease...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29653195/genome-wide-integration-study-of-circulating-mirnas-and-peripheral-whole-blood-mrnas-of-male-acute-ischemic-stroke-patients
#5
Yang Xue, Pengqi Yin, Guozhong Li, Di Zhong
Several circulating microRNAs (miRNAs) have been proved to serve as stable biomarkers in blood for acute ischemic stroke (AIS). However, the functions of these biomarkers remain elusive. By conducting the integration analysis of circulating miRNAs and peripheral whole blood mRNAs using bioinformatics methods, we explored the biological role of these circulating markers in peripheral whole blood at the genome-wide level. Stroke-related circulating miRNA profile data (GSE86291) and peripheral whole blood mRNA expression data (GSE16561) were collected from the Gene Expression Omnibus (GEO) datasets...
April 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29651892/the-intracerebral-hemorrhage-blood-transcriptome-in-humans-differs-from-the-ischemic-stroke-and-vascular-risk-factor-control-blood-transcriptomes
#6
Boryana Stamova, Bradley P Ander, Glen Jickling, Farah Hamade, Marc Durocher, Xinhua Zhan, Da Zhi Liu, Xiyuan Cheng, Heather Hull, Alan Yee, Kwan Ng, Natasha Shroff, Frank R Sharp
Understanding how the blood transcriptome of human intracerebral hemorrhage (ICH) differs from ischemic stroke (IS) and matched controls (CTRL) will improve understanding of immune and coagulation pathways in both disorders. This study examined RNA from 99 human whole-blood samples using GeneChip® HTA 2.0 arrays to assess differentially expressed transcripts of alternatively spliced genes between ICH, IS and CTRL. We used a mixed regression model with FDR-corrected p(Dx) < 0.2 and p < 0.005 and |FC| > 1...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29651234/pathophysiology-of-long-non-coding-rnas-in-ischemic-stroke
#7
REVIEW
Weimin Ren, Xiaobo Yang
Stroke is a neurological disease with high disability and fatality rates, and ischemic stroke accounts for 75% of all stroke cases. The underlying pathophysiologic processes of ischemic stroke include oxidative stress, toxicity of excitatory amino acids, excess calcium ions, increased apoptosis and inflammation. Long non-coding RNAs (lncRNAs) may participate in the regulation of the pathophysiologic processes of ischemic stroke as indicated by altered expression of lncRNAs in blood samples of acute ischemic stroke patients, animal models of focal cerebral ischemia and oxygen-glucose deprivation (OGD) cell models...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29651208/role-of-brain-biomarker-in-predicting-clinical-outcome-in-hypertensive-cerebrovascular-ischemic-stroke
#8
Anuradha Bharosay, Vivek Vikram Bharosay, Kiran Saxena, Meena Varma
This study was undertaken to evaluate the role of serum neuron specific enolase (NSE) in prediction of disability and neurological worsening in hypertensive ischemic cerebrovascular stroke. 80 hypertensive ischemic stroke patients diagnosed by a neurologist as per WHO definition along with radiological findings suggestive of cerebrovascular stroke and differentiating from hemorrhagic stroke and 60 controls having essential hypertension coming to hospital because of regular checkup or headache but with no neurological disease were included in the study...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29571758/s100%C3%AE-protein-as-a-predictor-of-poststroke-functional-outcome-a-prospective-study
#9
João Paulo Branco, Sandra Oliveira, João Sargento-Freitas, Joana Santos Costa, Gustavo Cordeiro, Luís Cunha, António Freire Gonçalves, João Pinheiro
BACKGROUND: Stroke is one of the leading causes of disability worldwide. Early prediction of poststroke disability using clinical models is of great interest, especially in the rehabilitation field. Although some biomarkers and neuroimaging techniques have shown potential predictive value, there are still insufficient data to support their clinical utility in predicting poststroke functional recovery. We aimed to assess the value of serum biomarkers (C-reactive protein [CRP], D-dimer, fibrinogen, and S100β protein) in predicting medium-term (12 weeks) functional outcome in patients with acute ischemic stroke...
March 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29560942/-the-neurotoxicity-biomarkers-as-potential-indicators-of-the-spinal-cord-ischemia
#10
G V Ponomarev, T V Lalayan, S A Dambinova, A A Skoromets
The study aimed at assessing the level of glutamate receptors antibodies (Abs) in blood serum and cerebrospinal fluid (CSF) of patients with spinal cord ischemia along with traditional diagnostic approaches. MATERIAL AND METHODS: Forty patients with spinal cord ischemia (10 with spinal stroke and 30 with subacute and chronic course of the disease) were enrolled. After exclusion of some participants, 27 patients continued the study. Comparison groups included 30 patients with ischemic stroke and 30 patients with radiculopathy...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29557747/blood-microrna-15a-correlates-with-il-6-igf-1-and-acute-cerebral-ischemia
#11
Wenjing Lu, Yang Wang, Yu Zhang, Huaibin Liang, Xuanqiang Tu, Jirong He, Guoyuan Yang, Lili Zeng
OBJECTIVE: To explore the function of blood microRNA-15a (miR-15a) in the pathogenesis of acute cerebral ischemia. METHODS: Blood samples were collected from acute ischemic stroke (AIS) patients within 72 h after onset and normal control healthy. A model of ischemia in human umbilical vein endothelial cells (HUVEC) was established by oxygen and glucose deprivation (OGD). MiR-15a in patients and in cells was measured by real-time quantitative polymerase chain reaction (qPCR)...
March 19, 2018: Current Neurovascular Research
https://www.readbyqxmd.com/read/29550910/shifts-in-leukocyte-counts-drive-the-differential-expression-of-transcriptional-stroke-biomarkers-in-whole-blood
#12
Grant C O'Connell, Madison B Treadway, Connie S Tennant, Noelle Lucke-Wold, Paul D Chantler, Taura L Barr
Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution of the ten genes across the peripheral immune system by measuring their expression levels on isolated neutrophils, monocytes, B-lymphocytes, CD-4+ T-lymphocytes, CD-8+ T-lymphocytes, and NK-cells generated from the blood of healthy donors (n = 3)...
March 17, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29499637/chronic-kidney-disease-and-poor-outcomes-in-ischemic-stroke-is-impaired-cerebral-autoregulation-the-missing-link
#13
Pedro Castro, Elsa Azevedo, Isabel Rocha, Farzaneh Sorond, Jorge M Serrador
BACKGROUND: Chronic kidney disease increases stroke incidence and severity but the mechanisms behind this cerebro-renal interaction are mostly unexplored. Since both vascular beds share similar features, microvascular dysfunction could be the possible missing link. Therefore, we examined the relationship between renal function and cerebral autoregulation in the early hours post ischemia and its impact on outcome. METHODS: We enrolled 46 ischemic strokes (middle cerebral artery)...
March 2, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29490898/prehospital-advanced-diagnostics-and-treatment-of-acute-stroke-protocol-for-a-controlled-intervention-study
#14
Kristi G Bache, Maren Ranhoff Hov, Karianne Larsen, Volker Moræus Solyga, Christian G Lund
BACKGROUND: Acute ischemic stroke (AIS) is a medical emergency. The outcome is closely linked to the time elapsing from symptom onset to treatment, and seemingly small delays can mean the difference between full recovery and physical and cognitive dysfunction. Recanalization to allow blood to reenter the affected area is most efficient immediately after symptoms occur, and intravenous thrombolysis must be initiated no later than 4.5 hours after the symptom onset. A liable diagnosis is mandatory to administer the appropriate treatment...
February 28, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29467715/limb-remote-ischemic-conditioning-mechanisms-anesthetics-and-the-potential-for-expanding-therapeutic-options
#15
REVIEW
Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Sylvain Doré
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29444972/usefulness-of-adamts13-to-predict-response-to-recanalization-therapies-in-acute-ischemic-stroke
#16
Alejandro Bustamante, MingMing Ning, Teresa García-Berrocoso, Anna Penalba, Cristina Boada, Alba Simats, Jorge Pagola, Marc Ribó, Carlos Molina, Eng Lo, Joan Montaner
OBJECTIVE: We aimed to analyze ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in relation to arterial recanalization in patients treated with IV tissue plasminogen activator (tPA) and in relation to futile recanalization in patients treated with mechanical thrombectomy. METHODS: Acute ischemic stroke patients (n = 108) with documented arterial occlusions treated with IV-tPA were selected. ADAMTS13 activity was measured by ELISA in samples collected before treatment...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29415332/ccl23-a-new-cc-chemokine-involved-in-human-brain-damage
#17
Alba Simats, Teresa García-Berrocoso, Anna Penalba, Dolors Giralt, Gemma Llovera, Yinghua Jiang, Laura Ramiro, Alejandro Bustamante, Elena Martinez-Saez, Francesc Canals, Xiaoying Wang, Arthur Liesz, Anna Rosell, Joan Montaner
BACKGROUND: CCL23 role in the inflammatory response after acute brain injuries remains elusive. Here, we evaluated whether CCL23 blood levels associate with acquired cerebral lesions and determined CCL23 predictive capacity for assessing stroke prognosis. We used pre-clinical models to study the CCL23 homologous chemokines in rodents, CCL9 and CCL6. METHODS: Baseline CCL23 blood levels were determined on 245 individuals, including ischemic strokes (IS), stroke-mimics and controls...
February 7, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29414888/mass-spectrometry-based-proteomic-profiling-of-thrombotic-material-obtained-by-endovascular-thrombectomy-in-patients-with-ischemic-stroke
#18
Roberto Muñoz, Enrique Santamaría, Idoya Rubio, Karina Ausín, Aiora Ostolaza, Alberto Labarga, Miren Roldán, Beatriz Zandio, Sergio Mayor, Rebeca Bermejo, Mónica Mendigaña, María Herrera, Nuria Aymerich, Jorge Olier, Jaime Gállego, Maite Mendioroz, Joaquín Fernández-Irigoyen
Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein cargo of thrombi derived from AIS patients. To analyze the thrombus proteome in a large-scale format, we developed a workflow that combines the isolation of thrombus by endovascular thrombectomy and peptide chromatographic fractionation coupled to mass-spectrometry. Using this workflow, we have characterized a specific proteomic expression profile derived from four AIS patients included in this study...
February 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29386475/ability-of-b-type-natriuretic-peptide-testing-to-predict-cardioembolic-stroke-in-the-general-population%C3%A3-comparisons-with-c-reactive-protein-and-urinary-albumin
#19
Motoyuki Nakamura, Yasuhiro Ishibashi, Fumitaka Tanaka, Shinichi Omama, Toshiyuki Onoda, Tomohiro Takahashi, Shuko Takahashi, Kozo Tanno, Masaki Ohsawa, Kiyomi Sakata, Makoto Koshiyama, Kuniaki Ogasawara, Akira Okayama
BACKGROUND: The ability of cardiovascular biomarkers to predict the incidence of stroke subtypes remains ill-defined in the general population.Methods and Results:The blood levels of B-type natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) and urinary albumin corrected by urinary creatinine (UACR) were determined in a general population (n=13,575). The ability to predict the incidence of ischemic stroke subtypes (lacunar, atherothrombotic, cardioembolic) for each biomarker was assessed based on the area under the receiver-operating characteristic curve (AUC-ROC) and using Cox proportional hazard modeling...
January 30, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29368175/differential-proteomics-for-distinguishing-ischemic-stroke-from-controls-a-pilot-study-of-the-spectra-project
#20
A M Penn, V Saly, A Trivedi, M L Lesperance, K Votova, A M Jackson, N S Croteau, R F Balshaw, M B Bibok, D S Smith, K K Lam, J Morrison, L Lu, S B Coutts, C H Borchers
A diagnostic blood test for stroke is desirable but will likely require multiple proteins rather than a single "troponin." Validating large protein panels requires large patient numbers. Mass spectrometry (MS) is a cost-effective tool for this task. We compared differences in the abundance of 147 protein markers to distinguish 20 acute cerebrovascular syndrome (ACVS) patients who presented to the Emergency Department of one urban hospital within < 24 h from onset) and from 20 control patients who were enrolled via an outpatient neurology clinic...
January 24, 2018: Translational Stroke Research
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