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Ischemic stroke biomarkers in blood

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https://www.readbyqxmd.com/read/27905388/-prognostic-biochemical-markers-of-thrombolytic-therapy-in-ischemic-stroke
#1
O A Kicherova, L I Reikhert, V G Skorikova, S A Semeshko
AIM: To assess prognostic value of endothelial dysfunction, endogenous intoxication and oxidative stress in the acute period of ischemic stroke (II) at the stage of making a decision on using thrombolytic therapy (TLT) as well during the follow-up in order to personalize treatment. MATERIAL AND METHODS: The study included 57 patients stratified into control group 1 (n=29) and TLT group (n=28). Contents of C-reactive protein (Nsrb), matrixmetalloproteinase-9 (MMP-9) erythrocyte lipid peroxidation products were measured in the blood of patients...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904159/copeptin-as-a-biomarker-for-prediction-of-prognosis-of-acute-ischemic-stroke-and-transient-ischemic-attack-a-meta-analysis
#2
Qian Xu, Yunfan Tian, Hao Peng, Hongmei Li
This meta-analysis aimed to investigate the predictive effect of copeptin as a biomarker for the prognosis of acute ischemic stroke and transient ischemic attack. Electronic databases including PubMed, Medline, EMBASE, Web of Science and Cochrane Central were searched for studies assessing the association of copeptin level on admission with prognosis of acute ischemic stroke and transient ischemic attack. The Newcastle-Ottawa Quality assessment scale for cohort study was used to evaluate quality. A total of 1976 acute ischemic stroke patients from 6 studies were included, and 59% of patients were male...
December 1, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27899750/circulating-micrornas-as-novel-biomarkers-of-stenosis-progression-in-asymptomatic-carotid-stenosis
#3
Sandra Dolz, David Górriz, José Ignacio Tembl, Dolors Sánchez, Gerardo Fortea, Vera Parkhutik, Aida Lago
BACKGROUND AND PURPOSE: Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers of ACAS progression are lacking. Recent studies suggest a regulatory function for several microRNAs (miRNAs) on the evolution of carotid plaque, but its role in ACAS progression is mostly unknown. The aim of our study was to investigate a wide miRNA panel in peripheral blood exosomes from patients with ACAS to associate circulating miRNA expression profiles with stenosis progression...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27884769/upregulation-of-cd74-and-its-potential-association-with-disease-severity-in-subjects-with-ischemic-stroke
#4
Liu Yang, Ying Kong, Honglei Ren, Minshu Li, Chang-Juan Wei, Elaine Shi, Wei-Na Jin, Junwei Hao, Arthur A Vandenbark, Halina Offner
Macrophage migration inhibitory factor (MIF) is a key cytokine/chemokine in the activation and recruitment of inflammatory T lymphocytes known to exacerbate experimental stroke severity. MIF effects are mediated through its primary cellular receptor, CD74, the MHC class II invariant chain present on all class II expressing cells, including monocytes, macrophages and dendritic cells (DC). We demonstrated previously that partial MHC class II/peptide constructs (pMHC) can effectively treat mice with experimental stroke, in part through their ability to competitively inhibit MIF/CD74 interactions and downstream signaling...
November 21, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27881450/glial-fibrillary-acidic-protein-serum-levels-distinguish-between-intracerebral-hemorrhage-and-cerebral-ischemia-in-the-early-phase-of-stroke
#5
Sebastian Luger, Jens Witsch, Andreas Dietz, Gerhard F Hamann, Jens Minnerup, Hauke Schneider, Matthias Sitzer, Katja E Wartenberg, Marion Niessner, Christian Foerch
BACKGROUND: Recent studies have suggested that glial fibrillary acidic protein (GFAP) serum concentrations distinguish between intracerebral hemorrhage (ICH) and ischemic stroke (IS) shortly after symptom onset. In this prospective multicenter trial we validated GFAP in an independent patient cohort and assessed the quantitative relationship between GFAP release, bleeding size, and localization. METHODS: We included patients with a persistent neurological deficit (NIH Stroke Scale ≥4) suggestive of stroke within 6 h of symptom onset...
November 23, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27834745/altered-expression-of-long-noncoding-rnas-in-blood-after-ischemic-stroke-and-proximity-to-putative-stroke-risk-loci
#6
Cheryl Dykstra-Aiello, Glen C Jickling, Bradley P Ander, Natasha Shroff, Xinhua Zhan, DaZhi Liu, Heather Hull, Miles Orantia, Boryana S Stamova, Frank R Sharp
BACKGROUND AND PURPOSE: Although peripheral blood mRNA and micro-RNA change after ischemic stroke, any role for long noncoding RNA (lncRNA), which comprise most of the genome and have been implicated in various diseases, is unknown. Thus, we hypothesized that lncRNA expression also changes after stroke. METHODS: lncRNA expression was assessed in 266 whole-blood RNA samples drawn once per individual from patients with ischemic stroke and matched with vascular risk factor controls...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27780987/prediction-of-outcome-in-diabetic-acute-ischemic-stroke-patients-a-hospital-based-pilot-study-report
#7
Amit R Nayak, Shweta R Badar, Neha Lande, Anuja P Kawle, Dinesh P Kabra, Nitin H Chandak, Dhananjay V Raje, Lokendra R Singh, Hatim F Daginawala, Rajpal S Kashyap
BACKGROUND: Demographic and clinical characteristics are known to influence the outcome in acute ischemic stroke (AIS) patients. PURPOSE: This study is aimed at evaluating short- and long-term outcomes in diabetic AIS patients. In addition, the study also evaluates the impact of diabetes on the performance of indigenously reported biomarker, inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and known biomarkers, neuron-specific enolase (NSE) and glial-derived S-100 beta beta protein (S-100ββ)...
October 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27778531/basic-mechanisms-of-platelet-receptor-shedding
#8
Robert K Andrews, Elizabeth E Gardiner
Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease. Platelets derived from megakaryocytes are small anucleate cells in peripheral blood, with the ability to rapidly adhere, become activated, and secrete an array of procoagulant and proinflammatory factors at sites of vascular injury or disease, and to form a platelet aggregate (thrombus) which is not only critical in normal hemostasis and wound healing, but in atherothrombotic diseases including myocardial infarction and ischemic stroke...
October 25, 2016: Platelets
https://www.readbyqxmd.com/read/27776204/mean-platelet-volume-a-potential-biomarker-of-the-risk-and-prognosis-of-heart-disease
#9
Dong-Hyun Choi, Seong-Ho Kang, Heesang Song
Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy...
October 24, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27776139/identification-of-blood-let-7e-5p-as-a-biomarker-for-ischemic-stroke
#10
Suli Huang, Ziquan Lv, Yi Guo, Lu Li, Yanwei Zhang, Li Zhou, Binyao Yang, Shuang Wu, Ying Zhang, Changhui Xie, Shanshan Li, Jinquan Cheng
Circulating microRNAs (miRNAs) are emerging as novel disease biomarkers. Using a miRNA microarray, we previously showed that the whole blood level of let-7e-5p was significantly higher in ischemic stroke patients than in control subjects. However, the association between let-7e-5p expression and the occurrence of ischemic stroke remains unknown. In this study, we validated the expression levels of let-7e-5p in two case-control populations using miRNA TaqMan assays and further investigated the potential targets of let-7e-5p...
2016: PloS One
https://www.readbyqxmd.com/read/27771707/peripheral-immune-cell-counts-and-advanced-imaging-as-biomarkers-of-stroke-outcome
#11
Heather Pagram, Andrew Bivard, Lisa F Lincz, Christopher Levi
INTRODUCTION: Circulating neutrophil and lymphocyte levels may be modifiable outcome predictors of ischemic stroke. We sought to compare these immune cell parameters with advanced imaging assessment and the 90-day clinical outcome. METHODS: We used a retrospectively collected cohort of consecutive ischemic stroke patients presenting within 4.5 h of symptom onset who had acute CT perfusion and routine blood collection before treatment with intravenous thrombolysis and 24-hour MRI scanning at the John Hunter Hospital...
January 22, 2016: Cerebrovascular Diseases Extra
https://www.readbyqxmd.com/read/27753832/sy-04-2-long-term-cvd-risk-prediction-in-low-incidence-european-populations
#12
Giovanni Veronesi
In Italy, the European SCORE Project risk score is the recommended tool for cardiovascular disease risk stratification in the primary prevention setting. Among non-diabetic subjects aged 40 to 64, the model estimates the 10-year probability of death due to cardiovascular disease based on individual's age, total cholesterol, blood pressure and smoking status. A growing body of evidence suggests that in middle-aged adults this stratification may suffer from two major drawbacks. First, mortality risk severely underestimates the global burden of disease incidence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27682886/retinal-vessel-calibers-in-predicting-long-term-cardiovascular-outcomes-the-atherosclerosis-risk-in-communities-study
#13
Sara B Seidelmann, Brian Claggett, Paco E Bravo, Ankur Gupta, Hoshang Farhad, Barbara E Klein, Ronald Klein, Marcelo F Di Carli, Scott D Solomon
BACKGROUND: -Narrower retinal arterioles and wider retinal venules have been associated with negative cardiovascular outcomes. We investigated whether retinal vessel calibers are associated with cardiovascular outcomes in long-term follow-up and provide incremental value over the 2013 American College of Cardiology/American Heart Association pooled cohort equations (PCE) in predicting Atherosclerotic Cardiovascular Disease Events (ASCVE). METHODS: -10,470 men and women without prior ASCVE or heart failure (HF) in the Atherosclerosis Risk in Communities (ARIC) study underwent retinal photography at visit 3 (1993-1995)...
September 28, 2016: Circulation
https://www.readbyqxmd.com/read/27673422/fifty-years-of-brain-imaging-in-neonatal-encephalopathy-following-perinatal-asphyxia
#14
Floris Groenendaal, Linda S de Vries
In the past brain imaging of term infants with HIE was performed with cranial ultrasound (cUS) and computed tomography (CT). Both techniques have several disadvantages, sensitivity and specificity are limited compared to MRI, and CT makes use of radiation.At present MRI including diffusion weighted MRI during the first week of life, has become the method of choice for imaging infants with HIE. In addition to imaging, blood vessels and blood flow can be visualized using MR angiography, MR venography, and arterial spin labeling...
September 27, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27660006/identification-of-more-objective-biomarkers-for-blood-stasis-syndrome-diagnosis
#15
Jiangquan Liao, Yongmei Liu, Jie Wang
BACKGROUND: Blood-stasis syndrome (BSS) is one of the Traditional Chinese medicine (TCM) syndrome differentiations that are commonly seen in stroke and ischemic heart diseases; however, the BSS differentiation criterion is not standardized. More objective biomarkers for BSS diagnosis are needed. METHODS: Acute ischemic stroke (AIS) or unstable angina (UA) patients with BSS and healthy controls were enrolled. The miRNA and mRNA expression profiles of UA patients and AIS patients were compared to those of healthy controls to identify the differentially expressed miRNA and mRNA of BSS...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27642885/sy-04-2-long-term-cvd-risk-prediction-in-low-incidence-european-populations
#16
Giovanni Veronesi
In Italy, the European SCORE Project risk score is the recommended tool for cardiovascular disease risk stratification in the primary prevention setting. Among non-diabetic subjects aged 40 to 64, the model estimates the 10-year probability of death due to cardiovascular disease based on individual's age, total cholesterol, blood pressure and smoking status. A growing body of evidence suggests that in middle-aged adults this stratification may suffer from two major drawbacks. First, mortality risk severely underestimates the global burden of disease incidence...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642014/ultra-acute-diagnostics-for-stroke-large-scale-implementation-of-prehospital-biomarker-sampling
#17
O S Mattila, H Harve, S Pihlasviita, J Ritvonen, G Sibolt, M Pystynen, D Strbian, S Curtze, M Kuisma, T Tatlisumak, P J Lindsberg
OBJECTIVES: Blood-based biomarkers could enable early and cost-effective diagnostics for acute stroke patients in the prehospital setting to support early initiation of treatments. To facilitate development of ultra-acute biomarkers, we set out to implement large-scale prehospital blood sampling and determine feasibility and diagnostic timesavings of this approach. MATERIALS AND METHODS: Emergency medical services (EMS) personnel of the Helsinki metropolitan area were trained to collect prehospital blood samples from thrombolysis candidates using a cannula adapter technique...
September 18, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27639588/plasma-immunoproteasome-predicts-early-hemorrhagic-transformation-in-acute-ischemic-stroke-patients
#18
Xingyong Chen, Yinzhou Wang, Ming Fu, Huixin Lei, Qiong Cheng, Xu Zhang
BACKGROUND AND PURPOSE: Currently, blood biomarkers associated with an increased hemorrhagic transformation (HT) risk remain uncertain. We aimed to determine the significance of immunoproteasome as predictors of early HT in acute ischemic stroke patients. METHODS: This study enrolled 316 patients with ischemic stroke. HT was assessed by computed tomography examination performed on day 5 ± 2 after stroke onset or immediately in case of clinical deterioration (CD)...
September 14, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27634651/epigenome-wide-association-study-reveals-differential-dna-methylation-in-individuals-with-a-history-of-myocardial-infarction
#19
Mathias Rask-Andersen, David Martinsson, Muhammad Ahsan, Stefan Enroth, Weronica E Ek, Ulf Gyllensten, Åsa Johansson
Cardiovascular diseases (CVDs) are the leading causes of death worldwide and represent a substantial economic burden on public health care systems. Epigenetic markers have potential as diagnostic markers before clinical symptoms have emerged, and as prognostic markers to inform the choice of clinical intervention. In this study, we performed an epigenome-wide association study (EWAS) for CVDs, to identify disease-specific alterations in DNA methylation. CpG methylation in blood samples from the northern Sweden population health study (NSPHS) (n = 729) was assayed on the Illumina Infinium HumanMethylation450 BeadChip...
September 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27624369/investigation-of-oxidant-and-antioxidant-levels-in-patients-with-acute-stroke-in-the-emergency-service
#20
İsmail Atik, Nalan Kozacı, İnan Beydilli, Mustafa Avcı, Hamit Ellidağ, Mustafa Keşaplı
OBJECTIVE: In this study, we aimed to identify oxidative stress and the disruption in the oxidant-antioxidant balance in the acute phase of stroke and, therefore, to detect markers that will guide in the diagnosis and treatment of stroke. MATERIALS AND METHODS: Eighty-six patients who were admitted to Antalya Training and Research Hospital Emergency Department between June 2013 and December 2013 and who were diagnosed as having stroke were enrolled in this study...
August 30, 2016: American Journal of Emergency Medicine
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