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Keywords Biomarker panels in ischemic s...

Biomarker panels in ischemic stroke

https://read.qxmd.com/read/38420847/potential-protein-signatures-for-recurrence-prediction-of-ischemic-stroke
#1
JOURNAL ARTICLE
Chengyi Zhang, Yang Liu, Huimin Zhu, Xinying Huang, Cang Guo, Si Cheng, Meng Yuan, Yong Jiang, Xia Meng, S Claiborne Johnston, Yongjun Wang, Wei-Na Jin, Fu-Dong Shi
BACKGROUND: Acute ischemic stroke is a major cause of mortality and disability worldwide, with approximately 7.4% to 7.7% recurrence within the first 3 months. This study aimed to identify potential biomarkers for predicting stroke recurrence. METHODS AND RESULTS: We conducted a nested case-control study using a hospital-based cohort from the Third China National Stroke Registry selecting 214 age- and sex-matched patients with ischemic stroke with hypertension and no history of diabetes or heart disease...
February 29, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38381296/considering-context-specific-micrornas-in-ischemic-stroke-with-three-w-where-when-and-what
#2
REVIEW
Chuheng Chang, Youyang Wang, Renzhi Wang, Xinjie Bao
MicroRNAs are short non-coding RNA molecules that function as critical regulators of various biological processes through negative regulation of gene expression post-transcriptionally. Recent studies have indicated that microRNAs are potential biomarkers for ischemic stroke. In this review, we first illustrate the pathogenesis of ischemic stroke and demonstrate the biogenesis and transportation of microRNAs from cells. We then discuss several promising microRNA biomarkers in ischemic stroke in a context-specific manner from three dimensions: biofluids selection for microRNA extraction (Where), the timing of sample collection after ischemic stroke onset (When), and the clinical application of the differential-expressed microRNAs during stroke pathophysiology (What)...
February 21, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38380044/beyond-diagnosis-leveraging-routine-blood-and-urine-biomarkers-to-predict-severity-and-functional-outcome-in-acute-ischemic-stroke
#3
JOURNAL ARTICLE
Oluwaseun Adebayo Bamodu, Lung Chan, Chia-Hui Wu, Shun-Fan Yu, Chen-Chih Chung
BACKGROUND: The initial severity of acute ischemic stroke (AIS) is a crucial predictor of the disease outcome. In this study, blood and urine biomarkers from patients with AIS were measured to estimate stroke severity and predict long-term stroke outcomes. METHODS: The medical records of patients with AIS between October 2016 and May 2020 were retrospectively analyzed. The relationships of blood and urine biomarkers with stroke severity at admission were evaluated in patients with AIS...
February 29, 2024: Heliyon
https://read.qxmd.com/read/37806545/identification-of-serum-biomarkers-of-ischemic-stroke-in-a-hypertensive-population-based-on-metabolomics-and-lipidomics
#4
JOURNAL ARTICLE
Tian Zhao, Qianqian Yan, Changyi Wang, Jingjing Zeng, Ruijie Zhang, Han Wang, Liyuan Pu, Xiaoyu Dai, Huina Liu, Liyuan Han
Hypertensive individuals are at a high risk of stroke, and thus, prevention of stroke in hypertensive patients is essential. Metabolomics and lipidomics can be used to identify diagnostic biomarkers and conduct early assessments of stroke risk in hypertensive populations. In this study, serum samples were collected from 30 hypertensive ischemic stroke (IS), 30 matched hypertensive and 30 matched healthy participants. Metabolomics and lipidomics analyses were conducted via liquid chromatography-tandem mass spectrometry, and the data were analyzed using multivariate and univariate statistical methods...
November 21, 2023: Neuroscience
https://read.qxmd.com/read/37778160/non-coding-rnas-versus-protein-biomarkers-to-diagnose-and-differentiate-acute-stroke-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Barend W Florijn, M Leontien van der Bent, Truc My T Nguyen, Paul H A Quax, Marieke J H Wermer, A Yaël Nossent, Nyika D Kruyt
BACKGROUND: Stroke diagnosis is dependent on lengthy clinical and neuroimaging assessments, while rapid treatment initiation improves clinical outcome. Currently, more sensitive biomarker assays of both non-coding RNA- and protein biomarkers have improved their detectability, which could accelerate stroke diagnosis. This systematic review and meta-analysis compares non-coding RNA- with protein biomarkers for their potential to diagnose and differentiate acute stroke (subtypes) in (pre-)hospital settings...
September 29, 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/37721534/blood-biomarker-changes-following-therapeutic-hypothermia-in-ischemic-stroke
#6
JOURNAL ARTICLE
Elena Palà, Anna Penalba, Alejandro Bustamante, Teresa García-Berrocoso, Marcel Lamana-Vallverdú, Christian Meisel, Andreas Meisel, H Bart van der Worp, Malcolm R Macleod, Bernd Kallmünzer, Stefan Schwab, Joan Montaner
INTRODUCTION: Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling. METHODS: Blood samples from 54 patients included in the EuroHYP-1 study (27 treated with hypothermia, and 27 controls) were obtained at baseline, 24 ± 2 h, and 72 ± 4 h...
September 18, 2023: Brain and Behavior
https://read.qxmd.com/read/37682094/-serum-brain-damage-biomarkers-as-a-diagnostic-and-prognostic-tool-in-ischemic-stroke
#7
JOURNAL ARTICLE
A D Chaykovskaya, M P Topuzova, I K Ternovykh, A M Makhanova, A G Mikheeva, M L Pospelova, E B Panina, T V Vavilova, E Yu Vasilieva, T A Shustova, T M Alekseeva
OBJECTIVE: To study serum quantities of neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and NR2-antibodies (NR2-ab) in various cerebrovascular pathology and assess their value as a panel used as a diagnostic and predictive tool for stroke. MATERIAL AND METHODS: NSE, GFAP and NR2-ab serum levels were measured twice for 84 patients with ischemic stroke (IS) and 8 patients with hemorrhagic stroke (HI), once for 8 patients with transient ischemic attack (TIA), 26 patients with chronic brain ischemia (CBI), 27 healthy volunteers (HV)...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37675160/serum-biomarkers-to-predict-hemorrhagic-transformation-and-ischemic-stroke-outcomes-in-a-prospective-cohort-study
#8
JOURNAL ARTICLE
Elena Costru-Tasnic, Mihail Gavriliuc, Elena Manole
Ischemic stroke (IS) remains one of the most frequent causes of death and disability worldwide. Identifying possible prognosis factors for IS outcomes, including hemorrhagic transformation (HT), could improve patients' recovery. This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study...
June 2023: Journal of Medicine and Life
https://read.qxmd.com/read/37557961/machine-learning-models-of-plasma-proteomic-data-predict-mood-in-chronic-stroke-and-tie-it-to-aberrant-peripheral-immune-responses
#9
JOURNAL ARTICLE
Neda H Bidoki, Kristy A Zera, Huda Nassar, Lauren L Drag, Michael Mlynash, Elizabeth Osborn, Muhith Musabbir, Da Eun K Kim, Maria Paula Mendez, Maarten G Lansberg, Nima Aghaeepour, Marion S Buckwalter
Post-stroke depression is common, long-lasting and associated with severe morbidity and death, but mechanisms are not well-understood. We used a broad proteomics panel and developed a machine learning algorithm to determine whether plasma protein data can predict mood in people with chronic stroke, and to identify proteins and pathways associated with mood. We used Olink to measure 1,196 plasma proteins in 85 participants aged 25 and older who were between 5 months and 9 years after ischemic stroke. Mood was assessed with the Stroke Impact Scale mood questionnaire (SIS3)...
August 7, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/37522399/inflammation-biomarkers-in-acute-ischemic-stroke-according-to-different-etiologies
#10
JOURNAL ARTICLE
Christa Meisinger, Dennis Freuer, Timo Schmitz, Michael Ertl, Philipp Zickler, Markus Naumann, Jakob Linseisen
BACKGROUND: High throughput technologies provide new opportunities to further investigate the pathophysiology of ischemic strokes. The present cross-sectional study aimed to evaluate potential associations between the etiologic subtypes of ischemic stroke and blood-based proteins. METHODS: We investigated the associations between ischemic stroke subtypes and a panel of circulating inflammation biomarkers in 364 patients included in the Stroke Cohort Augsburg (SCHANA)...
July 31, 2023: European Journal of Neurology
https://read.qxmd.com/read/37511304/unlocking-the-potential-of-stroke-blood-biomarkers-early-diagnosis-ischemic-vs-haemorrhagic-differentiation-and-haemorrhagic-transformation-risk-a-comprehensive-review
#11
REVIEW
Lazzaro di Biase, Adriano Bonura, Pasquale Maria Pecoraro, Simona Paola Carbone, Vincenzo Di Lazzaro
Stroke, a complex and heterogeneous disease, is a leading cause of morbidity and mortality worldwide. The timely therapeutic intervention significantly impacts patient outcomes, but early stroke diagnosis is challenging due to the lack of specific diagnostic biomarkers. This review critically examines the literature for potential biomarkers that may aid in early diagnosis, differentiation between ischemic and hemorrhagic stroke, and prediction of hemorrhagic transformation in ischemic stroke. After a thorough analysis, four promising biomarkers were identified: Antithrombin III (ATIII), fibrinogen, and ischemia-modified albumin (IMA) for diagnostic purposes; glial fibrillary acidic protein (GFAP), micro RNA 124-3p, and a panel of 11 metabolites for distinguishing between ischemic and hemorrhagic stroke; and matrix metalloproteinase-9 (MMP-9), s100b, and interleukin 33 for predicting hemorrhagic transformation...
July 17, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37435550/metabolic-alterations-and-related-biological-functions-of-post-stroke-depression-in-ischemic-stroke-patients
#12
JOURNAL ARTICLE
Lulu Wen, Chuming Yan, Wancheng Zheng, Yi Li, Yuhui Wang, Miao Qu
BACKGROUND: Post-stroke depression (PSD) is one of the most common neuropsychiatric complications after stroke. However, the underlying mechanisms of PSD remain ambiguous, and no objective diagnosis tool is available to diagnose PSD. Previous metabolomic studies on PSD included patients with ischemic and hemorrhagic stroke indiscriminately, which is not conducive to elucidating and predicting the occurrence of PSD. The aim of this study is to elucidate the pathogenesis of PSD and provide potential diagnostic markers for PSD in ischemic stroke patients...
2023: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/37260778/a-severity-score-and-outcome-prediction-in-patients-that-suffered-an-ischemic-stroke
#13
JOURNAL ARTICLE
Corina Roman-Filip, Maria-Gabriela Catană Vlădoiu, Mădălina Văleanu, Romeo-Gabriel Mihăilă
BACKGROUND: Stroke is the main cause of disability and exitus worldwide. The prediction of mortality of this pathology represents a major challenge. More than that, the infection with the SARS-CoV-2 virus is a challenge for every clinician worldwide, and hypercoagulability is one of its biggest concerns that can lead to stroke. OBJECTIVE: Our aim was to develop a severity stroke index for both SARS-CoV-2 stroke patients and noninfected stroke patients which we hope to be helpful in patient's management...
2023: Emergency Medicine International
https://read.qxmd.com/read/37175644/multiplexing-biosensor-for-the-detection-of-extracellular-vesicles-as-biomarkers-of-tissue-damage-and-recovery-after-ischemic-stroke
#14
JOURNAL ARTICLE
Silvia Picciolini, Valentina Mangolini, Francesca Rodà, Angelo Montesano, Francesca Arnaboldi, Piergiuseppe Liuzzi, Andrea Mannini, Marzia Bedoni, Alice Gualerzi
The inflammatory, reparative and regenerative mechanisms activated in ischemic stroke patients immediately after the event cooperate in the response to injury, in the restoration of functions and in brain remodeling even weeks after the event and can be sustained by the rehabilitation treatment. Nonetheless, patients' response to treatments is difficult to predict because of the lack of specific measurable markers of recovery, which could be complementary to clinical scales in the evaluation of patients. Considering that Extracellular Vesicles (EVs) are carriers of multiple molecules involved in the response to stroke injury, in the present study, we have identified a panel of EV-associated molecules that (i) confirm the crucial involvement of EVs in the processes that follow ischemic stroke, (ii) could possibly profile ischemic stroke patients at the beginning of the rehabilitation program, (iii) could be used in predicting patients' response to treatment...
April 27, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37122289/targeted-metabolomics-reveals-serum-changes-of-amino-acids-in-mild-to-moderate-ischemic-stroke-and-stroke-mimics
#15
JOURNAL ARTICLE
Shuxin Tao, Xinxing Xiao, Xin Li, Fan Na, Guo Na, Shuang Wang, Pin Zhang, Fang Hao, Peiran Zhao, Dong Guo, Xuewu Liu, Dawei Yang
BACKGROUND: The pathophysiological processes linked to an acute ischemic stroke (IS) can be reflected in the circulating metabolome. Amino acids (AAs) have been demonstrated to be one of the most significant metabolites that can undergo significant alteration after a stroke. METHODS: We sought to identify the potential biomarkers for the early detection of IS using an extensive targeted technique for reliable quantification of 27 different AAs based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36845280/short-communication-unique-metabolic-signature-of-proliferative-retinopathy-in-the-tear-fluid-of-diabetic-patients-with-comorbidities-preliminary-data-for-pppm-validation
#16
JOURNAL ARTICLE
Martina Kropp, Eline De Clerck, Trong-Tin Kevin Steve Vo, Gabriele Thumann, Vincenzo Costigliola, Olga Golubnitschaja
Type 2 diabetes (T2DM) defined as the adult-onset type that is primarily not insulin-dependent, comprises over 95% of all diabetes mellitus (DM) cases. According to global records, 537 million adults aged 20-79 years are affected by DM that means at least 1 out of 15 persons. This number is projected to grow by 51% by the year 2045. One of the most common complications of T2DM is diabetic retinopathy (DR) with an overall prevalence over 30%. The total number of the DR-related visual impairments is on the rise, due to the growing T2DM population...
February 22, 2023: EPMA Journal
https://read.qxmd.com/read/36818315/prognostic-markers-for-ischemic-stroke-are-they-truly-reliable
#17
JOURNAL ARTICLE
Corina Roman-Filip, Maria-Gabriela Catană, Romeo-Gabriel Mihăilă
BACKGROUND: Stroke is one of the leading causes of mortality and morbidity worldwide. Despite extensive research, to this date there is no panel of biomarkers for the prevention and prognosis of ischemic stroke and there is still much incomplete and insufficiently researched information. AIM: We conducted a prospective, observational study between January and June 2020. The main objective of this study was to clarify the role of inflammation markers, i.e. neutrophil/ lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), high-sensitivity C - reactive protein (hsCRP) in ischemic stroke and whether there is or not a correlation between these markers and carotid stenosis...
January 2023: Medicine and pharmacy reports
https://read.qxmd.com/read/36713888/patient-characteristics-and-outcomes-of-acute-myocardial-infarction-presenting-without-ischemic-pain-insights-from-the-atherosclerosis-risk-in-communities-study
#18
JOURNAL ARTICLE
Bailey M DeBarmore, Jessica K Zègre-Hemsey, Anna M Kucharska-Newton, Erin D Michos, Wayne D Rosamond
BACKGROUND: Our objective was to describe characteristics of patients presenting with and without ischemic pain among those diagnosed with acute myocardial infarction (MI) using individual-level data from the Atherosclerosis Risk in Communities Study from 2005 to 2019. METHODS: Acute MI included events deemed definite or probable MI by a physician panel based on ischemic pain, cardiac biomarkers, and ECG evidence. Patient characteristics included age at hospitalization, sex, race/ethnicity, comorbidities (smoking status, diabetes, hypertension, history of previous stroke, MI, or cardiovascular procedure, and history of valvular disease or cardiomyopathy) and in-hospital complications occurring during the event of interest (pulmonary edema, pulmonary embolism, in-hospital stroke, pneumonia, cardiogenic shock, ventricular fibrillation)...
January 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/36613546/circulating-microrna-profiling-identifies-distinct-microrna-signatures-in-acute-ischemic-stroke-and-transient-ischemic-attack-patients
#19
JOURNAL ARTICLE
Salman M Toor, Eman K Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J Thornalley, Sajitha V Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil, Ashfaq Shuaib, Nehad M Alajez, Omar M E Albagha
Transient ischemic attack (TIA) refers to a momentary neurologic deficit caused by focal cerebral, spinal or retinal ischemic insult. TIA is associated with a high risk of impending acute ischemic stroke (AIS), a neurologic dysfunction characterized by focal cerebral, spinal or retinal infarction. Understanding the differences in molecular pathways in AIS and TIA has merit for deciphering the underlying cause for neuronal deficits with long-term effects and high risks of morbidity and mortality. In this study, we performed comprehensive investigations into the circulating microRNA (miRNA) profiles of AIS ( n = 191) and TIA ( n = 61) patients...
December 21, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36409382/baseline-severity-and-soluble-vascular-cell-adhesion-molecule-1-svcam-1-as-biomarker-predictors-of-short-term-mortality-in-acute-ischemic-stroke
#20
JOURNAL ARTICLE
Maria Caroline Martins de Araújo, Daniela Frizon Alfieri, Ana Lucia Cruz Fürstenberger Lehmann, Tamires Flauzino Luz, Emmanuelle Roberto Trevisani, Maisa Rocha Nagao, Leonardo Bodner de Freitas, Andrea Name Colado Simão, Edna Maria Vissoci Reiche
The aim was to investigate the association between plasma levels of cellular adhesion molecules (CAMs) and risk factors, subtypes, severity and short-term mortality of acute ischemic stroke (IS), and to identify a panel of biomarkers to predict short-term mortality after IS. The prospective study evaluated 132 IS patients within 24 h of their hospital admission. The baseline IS severity was assessed using the National Institutes Health Stroke Scale (NIHSS) and categorized as mild (NIHSS < 5), moderate (NIHSS 5-14) and severe (NIHSS ≥ 15)...
November 21, 2022: Metabolic Brain Disease
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