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Biomarker panels in ischemic stroke

Ashkan Shoamanesh, Sarah R Preis, Alexa S Beiser, Carlos S Kase, Philip A Wolf, Ramachandran S Vasan, Emelia J Benjamin, Sudha Seshadri, Jose R Romero
OBJECTIVE: We related a panel of inflammatory biomarkers to risk of incident ischemic stroke (IIS) in a community-dwelling sample. METHODS: Stroke-free Framingham offspring attending examination cycle 7 (1998-2001) had 15 circulating inflammatory biomarkers measured. Cox proportional hazard models were used to calculate the hazard ratios (HRs) of IIS per SD increment of each biomarker. Model 1 included age and sex. Model 2 additionally adjusted for systolic blood pressure, hypertension treatment, current smoking, diabetes, cardiovascular disease, and atrial fibrillation...
September 20, 2016: Neurology
Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano, Maurizio Paciaroni
BACKGROUND: Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Matrix-Metalloproteinase-9 (MMP-9), and S100β protein generating a Multimarker index of these values (MMX). The aims of this prospective study in consecutive patients with ischemic or hemorrhagic stroke were to assess: 1) the rate of an increase of biomarkers (BNP, D-dimer, MMP-9 and S-100β) tested with the Triage Stroke Panel; 2) the correlation between the increase of these biomarkers and functional outcome at 4 months; 3) the risk factors for the increase of biomarkers...
2016: Immunity & Ageing: I & A
Xiaohao Zhang, Zhiguang Sun, Caixia Ding, Yinyan Tang, Xuemei Jiang, Yi Xie, Chuanyou Li, Lankun Zhang, Dan Hu, Tingting Li, Gelin Xu, Lei Sheng
BACKGROUND AND AIMS: Metabolic syndrome (MetS) has been associated with occurrence and prognosis of ischemic stroke. This study aimed to evaluate whether an association exists between MetS and early neurological deterioration (END) following acute ischemic stroke and the possible role inflammatory biomarkers play. METHODS AND RESULTS: . We conducted a prospective cohort investigation that involved 208 stroke patients within 48 hours from symptom onset. MetS was determined by the modified National Cholesterol Education Program/Adult Treatment Panel III criteria...
2016: Oxidative Medicine and Cellular Longevity
Alina González-Quevedo, Sergio González-García, Zenaida Hernández-Díaz, Otman Fernández Concepción, Luis Quevedo Sotolongo, Marisol Peña-Sánchez, Benjamín Márquez Rosales, Rosaralis Santiesteban Freixas, Isabel Fernández-Almirall, María Caridad Menéndez-Sainz, Rebeca Fernández-Carriera
The object of this work was to explore if blood based biomarkers of brain damage could predict subclinical brain lesions and clinical outcome during follow-up in asymptomatic hypertensive patients. This was a cross-sectional study including 101 patients with essential hypertension and no clinical evidence of neurological disease and 53 healthy controls, followed by a longitudinal study of 62 hypertensive patients for an average of 33 months. Serum concentrations of two brain specific proteins (S100B and neuron specific enolase - NSE) were determined at inclusion...
April 15, 2016: Journal of the Neurological Sciences
L N Solovyeva, A A Shmonin, Yu V Emanuel, M S Stolyarov, E A Bondareva, Mazing A V, N M Lazareva, I V Kholopova, T V Blinova, T V Kharitonova, S V Lapin, V L Emanuel, E V Melnikova
The laboratory biomarkers can effect on choice of tactics of treatment in patients with atherosclerotic stenosis ofcarotids and high risk of stroke. However, nowadays there is no established laboratory criteria of significant atherosclerotic affection of internal carotid. The purpose of study was to investigate informativeness of biomarkers of atherosclerosis in clinical molecuIar panel of expertise system of determining risk of stroke in patients with significant stenosis of carotid. The study included patients with 50-90% atherosclerotic stenosis of internal carotid in acute period of atherothrombotic stroke or transitory ischemic attack (group 1), patients with stable 50-90% atherosclerotic stenosis of inner carotid having no vascular events during 30 days before engaging into study (group II) and group of healthy volunteers without atherosclerosis of inner carotid...
October 2015: Klinicheskaia Laboratornaia Diagnostika
D M Stanca, I C Mărginean, O Sorițău, D F Mureșanu
A neurologic deficit of sudden onset conforming to a vascular territory is a clear clinical indication that a patient suffers from an acute stroke. However, the imagistic diagnostic confirmation is not always readily available. We are now able to offer comprehensive medical support for the patient after an acute stroke and to make a prodigious rehabilitation program after the damage is done, but this is not offering the chance for improvement. An opportunity to better diagnose ischemic stroke seems to be available by using neuronal biomarkers...
2015: Journal of Medicine and Life
Rakesh Sharma, Harsha Gowda, Sandip Chavan, Jayshree Advani, Dhanashree Kelkar, G S Sameer Kumar, Mitali Bhattacharjee, Raghothama Chaerkady, T S Keshava Prasad, Akhilesh Pandey, Dindagur Nagaraja, Rita Christopher
Acute ischemic stroke (AIS) is a devastating cerebrovascular disorder that leads to permanent physical and neurological disabilities in adults worldwide. Proteins associated with stroke pathogenesis may appear in the serum of AIS patients due to blood-brain barrier dysfunction, thus permitting the development of blood-based biomarkers for early diagnosis of stroke. These biomarkers could perhaps be an adjunct to the existing imaging modalities and aid in better management and therapeutic intervention during the course of the disease...
June 5, 2015: Journal of Proteome Research
Amir Shaban, Brett Hymel, Maria Chavez-Keatts, Jordan J Karlitz, Sheryl Martin-Schild
Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical research on the association between IBD and stroke. Methods. We retrospectively reviewed consecutive patients with acute ischemic stroke presenting to our medical center from 7/2008 to 9/2013. Patients with a history of IBD were identified...
2015: Gastroenterology Research and Practice
Zhixin Wu, Mingming Zhao, Mingfeng He, Hongke Zeng, Feng Tan, Kuangyi Li, Shenglong Chen, Qianpeng Han, Qiaosheng Wang
AIM: The aim of the study is to validate of the use of plasma B-type natriuretic peptide (BNP) point-of-care test platform in preliminary recognition of cardioembolic stroke patients in the emergency department (ED). METHODS: In our ED, emergency physicians prospectively assessed consecutive adult patients with acute phase of ischemic stroke and measured plasma BNP by point-of-care test platform on admission. The included patients with plasma BNP concentration more than 66...
April 2015: American Journal of Emergency Medicine
Glen C Jickling, Frank R Sharp
No abstract text is available yet for this article.
March 2015: Stroke; a Journal of Cerebral Circulation
Stefan Greisenegger, Helen C Segal, Annette I Burgess, Debbie L Poole, Ziyah Mehta, Peter M Rothwell
BACKGROUND AND PURPOSE: Premature death after transient ischemic attack or stroke is more often because of heart disease or cancer than stroke. Previous studies found blood biomarkers not usefully predictive of nonfatal stroke but possibly of all-cause death. This association might be explained by potentially treatable occult cardiac disease or cancer. We therefore aimed to validate the association of a panel of biomarkers with all-cause death, particularly cardiac death and cancer death, despite the absence of associations with risk of nonfatal vascular events...
March 2015: Stroke; a Journal of Cerebral Circulation
Ashkan Shoamanesh, Sarah R Preis, Alexa S Beiser, Ramachandran S Vasan, Emelia J Benjamin, Carlos S Kase, Philip A Wolf, Charles DeCarli, Jose R Romero, Sudha Seshadri
OBJECTIVE: We investigated the association between circulating biomarkers of inflammation and MRI markers of small vessel disease. METHODS: We performed a cross-sectional study relating a panel of 15 biomarkers, representing systemic inflammation (high-sensitivity C-reactive protein, interleukin-6, monocyte chemotactic protein-1, tumor necrosis factor α, tumor necrosis factor receptor 2, osteoprotegerin, and fibrinogen), vascular inflammation (intercellular adhesion molecule 1, CD40 ligand, P-selectin, lipoprotein-associated phospholipase A2 mass and activity, total homocysteine, and vascular endothelial growth factor), and oxidative stress (myeloperoxidase) to ischemic (white matter hyperintensities/silent cerebral infarcts) and hemorrhagic (cerebral microbleeds) markers of cerebral small vessel disease (CSVD) on MRI in 1,763 stroke-free Framingham offspring (mean age 60...
February 24, 2015: Neurology
Helen C Segal, Annette I Burgess, Debbie L Poole, Ziyah Mehta, Louise E Silver, Peter M Rothwell
BACKGROUND AND PURPOSE: Risk of recurrent stroke is high in the first few weeks after transient ischemic attack or stroke and clinical risk prediction tools have only limited accuracy, particularly after the hyperacute phase. Previous studies of the predictive value of biomarkers have been small, been done in selected populations, and have not concentrated on the acute phase or on intensively treated populations. We aimed to determine the predictive value of a panel of blood biomarkers in intensively treated patients early after transient ischemic attack and stroke...
October 2014: Stroke; a Journal of Cerebral Circulation
Nai-Wen Tsai, Lian-Hui Lee, Chi-Ren Huang, Wen-Neng Chang, Ya-Ting Chang, Yu-Jih Su, Yi-Fang Chiang, Hung-Chen Wang, Ben-Chung Cheng, Wei-Che Lin, Chia-Te Kung, Chih-Min Su, Yu-Jun Lin, Cheng-Hsien Lu
INTRODUCTION: Statins are reported to have anti-inflammatory and anti-oxidative effects aside from cholesterol-lowering effects. This study aimed to evaluate the effects of statin therapy on oxidized LDL (Ox-LDL) and the clinical outcome of patients with acute ischemic stroke (AIS). METHODS: This prospective study enrolled 120 patients with AIS divided in the statin (n = 55) and non-statin (n = 65) groups. Eighty sex- and age- matched participants were recruited as risk controls...
2014: Critical Care: the Official Journal of the Critical Care Forum
José Tuñón, Luis Blanco-Colio, Carmen Cristóbal, Nieves Tarín, Javier Higueras, Ana Huelmos, Joaquín Alonso, Jesús Egido, Dolores Asensio, Óscar Lorenzo, Ignacio Mahíllo-Fernández, Fernando Rodríguez-Artalejo, Jerónimo Farré, José Luis Martín-Ventura, Lorenzo López-Bescós
Patients with coronary artery disease may develop not only ischemic events but also heart failure and death due to previous myocardial damage. The purpose of this study was to test the prognostic value of a panel of plasma biomarkers related to vascular (monocyte chemoattractant protein-1 [MCP-1] and soluble tumor necrosis factor-like weak inducer of apoptosis) and myocardial damage (galectin-3, N-terminal fragment of brain natriuretic peptide [NT-proBNP], and neutrophil gelatinase-associated lipocalin) in 706 patients with chronic coronary artery disease followed for 2...
February 1, 2014: American Journal of Cardiology
Richa Sharma, Stephanie Macy, Kara Richardson, Yuliya Lokhnygina, Daniel T Laskowitz
BACKGROUND: The aim of this study was to develop an adjunctive, peripheral biomarker test to differentiate ischemic strokes, intracranial hemorrhages (ICHs), and stroke mimics in the acute setting. METHODS: Serum samples were collected from 167 patients who presented with an acute neurologic deficit within 24 hours of symptom onset. Patients were adjudicated to ischemic stroke, ICH, and mimic pathology groups based on clinical and radiographic findings. Samples were tested for levels of 262 potential markers...
May 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Wu Zhixin, Yang Lianhong, Huang Wei, Li Lianda, Jiang Longyuan, Zhang Yingjian, Wang Jinliang, He Mingfeng
OBJECTIVE: To determine the value of the use of plasma B-type natriuretic peptide (BNP) among acute ischemic stroke patients in a Chinese emergency department (ED). MATERIALS AND METHODS: In our ED, the emergency physicians prospectively assessed consecutive adult patients with acute phase of ischemic stroke and measured plasma BNP by Biosite Triage(®)BNP POCT platform on admission, then followed up these patients. And the stroke neurologists evaluated patients' functional outcome at hospital discharge, and also made discharge diagnosis and stroke etiologic subtypes according to TOAST criteria: large-artery atherosclerosis (LAA), cardioembolism (CE), small-artery occlusion (SAO), stroke of other determined etiology (SOE) and stroke of other undetermined etiology (SUE)...
September 2013: Clinical Neurology and Neurosurgery
A Barbieri, E Giuliani, C Carone, F Pederzoli, G Mascheroni, G Greco, C Stucchi, S Genedani
BACKGROUND: Stroke is a leading cause of long-term morbidity and mortality affecting several hundred-thousand people annually in the Western Countries. Various panels of biomarkers of neural damage have been developed and validated. The primary objective of this investigation was to measure the correlation between the clinical severity of stroke and the serum/plasma concentrations of neural damage biomarkers. METHODS: A prospective investigation was conducted on a panel of biomarkers composed of S100β, matrix metalloproteinase-9 (MMP-9), N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and D-dimer at admission and after 24 hours, in a cohort patients with a confirmed diagnosis of stroke in an emergency setting (STROke-MArkers STROMA)...
July 2013: Minerva Anestesiologica
Naira Rico Santana, Edgar Zapico Muñiz, Dolores Cocho, Yolanda Bravo, Raquel Delgado Mederos, Joan Martí-Fàbregas
BACKGROUND: We sought to identify new serum biomarkers for the early diagnosis of ischemic stroke. METHODS: We collected 63 serum samples from patients with neurologic disease (45 patients with ischemic stroke, 18 patients with other neurologic disorders, and 56 healthy controls). Serum peptides were extracted using immobilized copper ion chromatography on a robotic platform. Mass spectra were acquired by matrix-assisted laser desorption/ionization-time of flight mass spectrometry using an Autoflex II spectrometer (Bruker Daltonics, Billerica, MA)...
February 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Aliaksei Kisialiou, Giordana Pelone, Albino Carrizzo, Giovanni Grillea, Valentina Trimarco, Marina Marino, Michelangelo Bartolo, Alessandro Marco De Nunzio, Rodolfo Grella, Alessandro Landolfi, Annibale Puca, Claudio Colonnese, Carmine Vecchione
UNLABELLED: HASH(0x448b1f0) BACKGROUND: Thrombolytic therapy (TT) for acute ischemic stroke (AIS) can provoke bleeding's complication depending on the ischemic lesion (IL) dimension. Inflammation involved in the setting of acute ischaemic stroke, is associated with infarct size. We aimed to study the independent correlation and association between clinical panel of routinely identified biomarkers, including inflammatory parameters, and cerebral IL dimension and site...
2012: Immunity & Ageing: I & A
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