keyword
MENU ▼
Read by QxMD icon Read
search

Biomarker panels in ischemic stroke

keyword
https://www.readbyqxmd.com/read/28716979/blood-biomarkers-for-the-early-diagnosis-of-stroke-the-stroke-chip-study
#1
Alejandro Bustamante, Elena López-Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa García-Berrocoso, Carles Ferrer-Costa, Teresa Gasull, María Hernández-Pérez, Mónica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, Helena Quesada, Mikel Terceño, Yolanda Silva, Mar Castellanos, Moisés Garces, Silvia Reverté, Xavier Ustrell, Rafael Marés, Joan Josep Baiges, Joaquín Serena, Francisco Rubio, Eduardo Salas, Antoni Dávalos, Joan Montaner
BACKGROUND AND PURPOSE: Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. METHODS: The Stroke-Chip was a prospective, observational, multicenter study, conducted at 6 Stroke Centers in Catalonia. Consecutive patients with suspected stroke were enrolled within the first 6 hours after symptom onset, and blood samples were drawn immediately after admission...
September 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28452132/blood-based-protein-biomarkers-for-stroke-differentiation-a-systematic-review
#2
REVIEW
Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha
Computed tomography (CT) scan is the mainstay for diagnosis of stroke; but the facility of CT scan is not easily available. A blood-based biomarker approach is required to distinguish ischemic stroke (IS) from hemorrhagic stroke (HS) in pre-hospital settings.To conduct a systematic review of diagnostic utility of blood biomarkers for differential diagnosis of stroke.A comprehensive literature search was carried out till March 7, 2017 in PubMed, Cochrane, Medline, OVID, and Google Scholar databases. Methodological quality of each study was assessed using the modified Quality Assessment of Diagnostic Accuracy Studies questionnaire...
September 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28222567/immune-biomarkers-for-the-diagnosis-of-mild-traumatic-brain-injury
#3
Ashley B Petrone, Valerie Gionis, Richard Giersch, Taura L Barr
BACKGROUND: In 2010, there were approximately 2.2 million emergency room visits associated with traumatic brain injury (TBI), with 80 percent diagnosed as mild TBI or concussion. In addition, there are a large number of TBIs, especially mild TBIs, which go either unreported by patients or initially undiagnosed by clinicians. Our team has previously identified a panel of immune-related genes that can diagnose ischemic stroke at triage, and due to shared pathophysiological mechanisms of TBI and stroke, we hypothesized that this panel of genes may also be utilized for the diagnosis of TBI...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28111353/gc-ms-based-metabolomics-identifies-an-amino-acid-signature-of-acute-ischemic-stroke
#4
Dian Wang, Jing Kong, Jiayan Wu, Xingxing Wang, Minchao Lai
Ischemic stroke is a serious public health problem worldwide. Here, we characterized the metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass spectrometry-based metabolomics. Forty AIS patients and 29 sex and age-matched controls were recruited. The serum metabolic profiles were significantly different between the two groups. Compared to the controls, the patients had elevated levels of lactate, carbonate and glutamate (P<0.01), and lowered levels of alanine, citrate, glycine, isoleucine, leucine, serine, tyrosine, methionine, tryptophan, erythronic acid, urea, purine, hypoxanthine, and proline in the serum (P<0...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28092160/discovery-of-metabolite-biomarkers-for-acute-ischemic-stroke-progression
#5
Peifang Liu, Ruiting Li, Anton A Antonov, Lihua Wang, Wei Li, Yunfei Hua, Huimin Guo, Lijuan Wang, Peijia Liu, Lixia Chen, Yuan Tian, Fengguo Xu, Zunjian Zhang, Yulan Zhu, Yin Huang
Stroke remains a major public health problem worldwide; it causes severe disability and is associated with high mortality rates. However, early diagnosis of stroke is difficult, and no reliable biomarkers are currently established. In this study, mass-spectrometry-based metabolomics was utilized to characterize the metabolic features of the serum of patients with acute ischemic stroke (AIS) to identify novel sensitive biomarkers for diagnosis and progression. First, global metabolic profiling was performed on a training set of 80 human serum samples (40 cases and 40 controls)...
February 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/27899750/circulating-micrornas-as-novel-biomarkers-of-stenosis-progression-in-asymptomatic-carotid-stenosis
#6
Sandra Dolz, David Górriz, José Ignacio Tembl, Dolors Sánchez, Gerardo Fortea, Vera Parkhutik, Aida Lago
BACKGROUND AND PURPOSE: Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers of ACAS progression are lacking. Recent studies suggest a regulatory function for several microRNAs (miRNAs) on the evolution of carotid plaque, but its role in ACAS progression is mostly unknown. The aim of our study was to investigate a wide miRNA panel in peripheral blood exosomes from patients with ACAS to associate circulating miRNA expression profiles with stenosis progression...
January 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27558379/circulating-biomarkers-and-incident-ischemic-stroke-in-the-framingham-offspring-study
#7
Ashkan Shoamanesh, Sarah R Preis, Alexa S Beiser, Carlos S Kase, Philip A Wolf, Ramachandran S Vasan, Emelia J Benjamin, Sudha Seshadri, Jose R Romero
OBJECTIVE: We related a panel of inflammatory biomarkers to risk of incident ischemic stroke (IIS) in a community-dwelling sample. METHODS: Stroke-free Framingham offspring attending examination cycle 7 (1998-2001) had 15 circulating inflammatory biomarkers measured. Cox proportional hazard models were used to calculate the hazard ratios (HRs) of IIS per SD increment of each biomarker. Model 1 included age and sex. Model 2 additionally adjusted for systolic blood pressure, hypertension treatment, current smoking, diabetes, cardiovascular disease, and atrial fibrillation...
September 20, 2016: Neurology
https://www.readbyqxmd.com/read/27247610/the-prognostic-value-of-biomarkers-in-stroke
#8
Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano, Maurizio Paciaroni
BACKGROUND: Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Matrix-Metalloproteinase-9 (MMP-9), and S100β protein generating a Multimarker index of these values (MMX). The aims of this prospective study in consecutive patients with ischemic or hemorrhagic stroke were to assess: 1) the rate of an increase of biomarkers (BNP, D-dimer, MMP-9 and S-100β) tested with the Triage Stroke Panel; 2) the correlation between the increase of these biomarkers and functional outcome at 4 months; 3) the risk factors for the increase of biomarkers...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27119010/metabolic-syndrome-augments-the-risk-of-early-neurological-deterioration-in-acute-ischemic-stroke-patients-independent-of-inflammatory-mediators-a-hospital-based-prospective-study
#9
Xiaohao Zhang, Zhiguang Sun, Caixia Ding, Yinyan Tang, Xuemei Jiang, Yi Xie, Chuanyou Li, Lankun Zhang, Dan Hu, Tingting Li, Gelin Xu, Lei Sheng
BACKGROUND AND AIMS: Metabolic syndrome (MetS) has been associated with occurrence and prognosis of ischemic stroke. This study aimed to evaluate whether an association exists between MetS and early neurological deterioration (END) following acute ischemic stroke and the possible role inflammatory biomarkers play. METHODS AND RESULTS: . We conducted a prospective cohort investigation that involved 208 stroke patients within 48 hours from symptom onset. MetS was determined by the modified National Cholesterol Education Program/Adult Treatment Panel III criteria...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27000243/serum-neuron-specific-enolase-could-predict-subclinical-brain-damage-and-the-subsequent-occurrence-of-brain-related-vascular-events-during-follow-up-in-essential-hypertension
#10
Alina González-Quevedo, Sergio González-García, Zenaida Hernández-Díaz, Otman Fernández Concepción, Luis Quevedo Sotolongo, Marisol Peña-Sánchez, Benjamín Márquez Rosales, Rosaralis Santiesteban Freixas, Isabel Fernández-Almirall, María Caridad Menéndez-Sainz, Rebeca Fernández-Carriera
The object of this work was to explore if blood based biomarkers of brain damage could predict subclinical brain lesions and clinical outcome during follow-up in asymptomatic hypertensive patients. This was a cross-sectional study including 101 patients with essential hypertension and no clinical evidence of neurological disease and 53 healthy controls, followed by a longitudinal study of 62 hypertensive patients for an average of 33 months. Serum concentrations of two brain specific proteins (S100B and neuron specific enolase - NSE) were determined at inclusion...
April 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26841665/-the-clinical-laboratory-markers-of-atherosclerosis-in-patients-with-atherothrombotic-stroke
#11
L N Solovyeva, A A Shmonin, Yu V Emanuel, M S Stolyarov, E A Bondareva, Mazing A V, N M Lazareva, I V Kholopova, T V Blinova, T V Kharitonova, S V Lapin, V L Emanuel, E V Melnikova
The laboratory biomarkers can effect on choice of tactics of treatment in patients with atherosclerotic stenosis ofcarotids and high risk of stroke. However, nowadays there is no established laboratory criteria of significant atherosclerotic affection of internal carotid. The purpose of study was to investigate informativeness of biomarkers of atherosclerosis in clinical molecuIar panel of expertise system of determining risk of stroke in patients with significant stenosis of carotid. The study included patients with 50-90% atherosclerotic stenosis of internal carotid in acute period of atherothrombotic stroke or transitory ischemic attack (group 1), patients with stable 50-90% atherosclerotic stenosis of inner carotid having no vascular events during 30 days before engaging into study (group II) and group of healthy volunteers without atherosclerosis of inner carotid...
October 2015: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/26366222/plasmatic-markers-for-early-diagnostic-and-treatment-decisions-in-ischemic-stroke
#12
REVIEW
D M Stanca, I C Mărginean, O Sorițău, D F Mureșanu
A neurologic deficit of sudden onset conforming to a vascular territory is a clear clinical indication that a patient suffers from an acute stroke. However, the imagistic diagnostic confirmation is not always readily available. We are now able to offer comprehensive medical support for the patient after an acute stroke and to make a prodigious rehabilitation program after the damage is done, but this is not offering the chance for improvement. An opportunity to better diagnose ischemic stroke seems to be available by using neuronal biomarkers...
2015: Journal of Medicine and Life
https://www.readbyqxmd.com/read/25807139/proteomic-signature-of-endothelial-dysfunction-identified-in-the-serum-of-acute-ischemic-stroke-patients-by-the-itraq-based-lc-ms-approach
#13
Rakesh Sharma, Harsha Gowda, Sandip Chavan, Jayshree Advani, Dhanashree Kelkar, G S Sameer Kumar, Mitali Bhattacharjee, Raghothama Chaerkady, T S Keshava Prasad, Akhilesh Pandey, Dindagur Nagaraja, Rita Christopher
Acute ischemic stroke (AIS) is a devastating cerebrovascular disorder that leads to permanent physical and neurological disabilities in adults worldwide. Proteins associated with stroke pathogenesis may appear in the serum of AIS patients due to blood-brain barrier dysfunction, thus permitting the development of blood-based biomarkers for early diagnosis of stroke. These biomarkers could perhaps be an adjunct to the existing imaging modalities and aid in better management and therapeutic intervention during the course of the disease...
June 5, 2015: Journal of Proteome Research
https://www.readbyqxmd.com/read/25784930/recurrent-posterior-strokes-in-inflammatory-bowel-disease-patients
#14
Amir Shaban, Brett Hymel, Maria Chavez-Keatts, Jordan J Karlitz, Sheryl Martin-Schild
Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical research on the association between IBD and stroke. Methods. We retrospectively reviewed consecutive patients with acute ischemic stroke presenting to our medical center from 7/2008 to 9/2013. Patients with a history of IBD were identified...
2015: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/25669874/validation-of-the-use-of-b-type-natriuretic-peptide-point-of-care-test-platform-in-preliminary-recognition-of-cardioembolic-stroke-patients-in-the-ed
#15
Zhixin Wu, Mingming Zhao, Mingfeng He, Hongke Zeng, Feng Tan, Kuangyi Li, Shenglong Chen, Qianpeng Han, Qiaosheng Wang
AIM: The aim of the study is to validate of the use of plasma B-type natriuretic peptide (BNP) point-of-care test platform in preliminary recognition of cardioembolic stroke patients in the emergency department (ED). METHODS: In our ED, emergency physicians prospectively assessed consecutive adult patients with acute phase of ischemic stroke and measured plasma BNP by point-of-care test platform on admission. The included patients with plasma BNP concentration more than 66...
April 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25657186/biomarker-panels-in-ischemic-stroke
#16
Glen C Jickling, Frank R Sharp
No abstract text is available yet for this article.
March 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25649803/biomarkers-and-mortality-after-transient-ischemic-attack-and-minor-ischemic-stroke-population-based-study
#17
Stefan Greisenegger, Helen C Segal, Annette I Burgess, Debbie L Poole, Ziyah Mehta, Peter M Rothwell
BACKGROUND AND PURPOSE: Premature death after transient ischemic attack or stroke is more often because of heart disease or cancer than stroke. Previous studies found blood biomarkers not usefully predictive of nonfatal stroke but possibly of all-cause death. This association might be explained by potentially treatable occult cardiac disease or cancer. We therefore aimed to validate the association of a panel of biomarkers with all-cause death, particularly cardiac death and cancer death, despite the absence of associations with risk of nonfatal vascular events...
March 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25632086/inflammatory-biomarkers-cerebral-microbleeds-and-small-vessel-disease-framingham-heart-study
#18
Ashkan Shoamanesh, Sarah R Preis, Alexa S Beiser, Ramachandran S Vasan, Emelia J Benjamin, Carlos S Kase, Philip A Wolf, Charles DeCarli, Jose R Romero, Sudha Seshadri
OBJECTIVE: We investigated the association between circulating biomarkers of inflammation and MRI markers of small vessel disease. METHODS: We performed a cross-sectional study relating a panel of 15 biomarkers, representing systemic inflammation (high-sensitivity C-reactive protein, interleukin-6, monocyte chemotactic protein-1, tumor necrosis factor α, tumor necrosis factor receptor 2, osteoprotegerin, and fibrinogen), vascular inflammation (intercellular adhesion molecule 1, CD40 ligand, P-selectin, lipoprotein-associated phospholipase A2 mass and activity, total homocysteine, and vascular endothelial growth factor), and oxidative stress (myeloperoxidase) to ischemic (white matter hyperintensities/silent cerebral infarcts) and hemorrhagic (cerebral microbleeds) markers of cerebral small vessel disease (CSVD) on MRI in 1,763 stroke-free Framingham offspring (mean age 60...
February 24, 2015: Neurology
https://www.readbyqxmd.com/read/25158774/population-based-study-of-blood-biomarkers-in-prediction-of-subacute-recurrent-stroke
#19
Helen C Segal, Annette I Burgess, Debbie L Poole, Ziyah Mehta, Louise E Silver, Peter M Rothwell
BACKGROUND AND PURPOSE: Risk of recurrent stroke is high in the first few weeks after transient ischemic attack or stroke and clinical risk prediction tools have only limited accuracy, particularly after the hyperacute phase. Previous studies of the predictive value of biomarkers have been small, been done in selected populations, and have not concentrated on the acute phase or on intensively treated populations. We aimed to determine the predictive value of a panel of blood biomarkers in intensively treated patients early after transient ischemic attack and stroke...
October 2014: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/24423248/statin-therapy-reduces-oxidized-low-density-lipoprotein-level-a-risk-factor-for-stroke-outcome
#20
Nai-Wen Tsai, Lian-Hui Lee, Chi-Ren Huang, Wen-Neng Chang, Ya-Ting Chang, Yu-Jih Su, Yi-Fang Chiang, Hung-Chen Wang, Ben-Chung Cheng, Wei-Che Lin, Chia-Te Kung, Chih-Min Su, Yu-Jun Lin, Cheng-Hsien Lu
INTRODUCTION: Statins are reported to have anti-inflammatory and anti-oxidative effects aside from cholesterol-lowering effects. This study aimed to evaluate the effects of statin therapy on oxidized LDL (Ox-LDL) and the clinical outcome of patients with acute ischemic stroke (AIS). METHODS: This prospective study enrolled 120 patients with AIS divided in the statin (n = 55) and non-statin (n = 65) groups. Eighty sex- and age- matched participants were recruited as risk controls...
2014: Critical Care: the Official Journal of the Critical Care Forum
keyword
keyword
65563
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"