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Gene profiling reveals specific molecular pathways in the pathogenesis of atherosclerosis and cardiovascular disease

Carlos Perez-Sanchez, Nuria Barbarroja, Sebastiano Messineo, Patricia Ruiz-Limon, Antonio Rodriguez-Ariza, Yolanda Jimenez-Gomez, Munther A Khamashta, Eduardo Collantes-Estevez, M Jose Cuadrado, M Angeles Aguirre, Chary Lopez-Pedrera
OBJECTIVE: To identify shared and differential molecular pathways involved in the pathogenesis of atherosclerosis (AT) and cardiovascular disease (CVD) in systemic lupus erythematosus (SLE), primary antiphospholipid syndrome (APS) and APS associated with SLE (APS plus SLE). METHODS: 129 patients (42 APS, 31 APS plus SLE and 56 SLE) and 61 healthy donors were included. Microarray expression profiling was performed in monocytes. RT-PCR of selected genes and western blot were used to validate microarray data...
July 2015: Annals of the Rheumatic Diseases
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