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Oligometastatic

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https://www.readbyqxmd.com/read/29163540/local-high-dose-radiotherapy-induces-systemic-immunomodulating-effects-of-potential-therapeutic-relevance-in-oligometastatic-breast-cancer
#1
Elena Muraro, Carlo Furlan, Michele Avanzo, Debora Martorelli, Elisa Comaro, Aurora Rizzo, Damiana A Fae', Massimiliano Berretta, Loredana Militello, Alessandro Del Conte, Simon Spazzapan, Riccardo Dolcetti, Marco Trovo'
Local irradiation of cancer through radiotherapy can induce spontaneous regression of non-directly irradiated lesions, suggesting the involvement of systemic antitumor immune responses. In oligometastatic breast cancer (BC) patients, the use of stereotactic body radiotherapy (SBRT) favors the local control of treated lesions and may contribute to break local tolerance and release tumor-associated antigens (TAAs), improving host antitumor immunity. We performed a detailed immunomonitoring of BC patients undergoing SBRT to verify its ability to "switch on" the anti-tumor immunity both systemically, in peripheral blood, and locally, employing in vitro BC models...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29156014/exhaustive-preoperative-staging-increases-survival-in-resected-adrenal-oligometastatic-non-small-cell-lung-cancer-a-multicentre-study
#2
Julien De Wolf, Jocelyn Bellier, Francoise Lepimpec-Barthes, Francois Tronc, Christophe Peillon, Alain Bernard, Jean-Philippe Le Rochais, Olivier Tiffet, Edouard Sage, Alain Chapelier, Henri Porte
OBJECTIVES: Adrenal oligometastatic non-small-cell lung cancer is rare, and surgical management remains controversial. METHODS: We performed a multicentre, retrospective study from January 2004 to December 2014. The main objective was to evaluate survival in patients who had undergone adrenalectomy after resection of primary lung cancer. Secondary objectives were to determine prognostic, survival and recurrence factors. RESULTS: Fifty-nine patients were included...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29155507/the-role-of-radiation-therapy-in-the-modern-management-of-oligometastatic-disease
#3
Yan Li, Suyu Tao, Mengru Li, Duojie Li
Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29147583/patterns-of-progression-in-metastatic-estrogen-receptor-positive-breast-cancer-an-argument-for-local-therapy
#4
Patrick Kelly, Zhe Ma, Said Baidas, Rebecca Moroose, Nikita Shah, Roi Dagan, Eleftherios Mamounas, Justin Rineer
Purpose: Despite advances in endocrine therapy (ET), metastatic estrogen receptor positive breast cancer (BrCA) remains incurable. Though the mechanisms of resistance to ET have been studied extensively, the anatomic pattern of disease progression remains poorly characterized. The purpose of this study was to characterize the pattern of progression for patients receiving ET for metastatic BrCA. Methods: The records of 108 patients with metastatic BrCA who progressed on ET were reviewed...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29135665/cryoablation-of-bone-metastases-from-renal-cell-carcinoma-for-local-tumor-control
#5
Carly S Gardner, Joe E Ensor, Kamran Ahrar, Steven Y Huang, Sharjeel H Sabir, Nizar M Tannir, Valerae O Lewis, Alda L Tam
BACKGROUND: Patients with bone metastases from renal cell carcinoma often are not surgical candidates and have a poor prognosis. There are limited data on the use of cryoablation as a locoregional therapy for bone metastases. Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma. METHODS: We retrospectively reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29129384/radiofrequency-ablation-for-hepatic-oligometastatic-pancreatic-cancer-an-analysis-of-safety-and-efficacy
#6
Yong-Qiang Hua, Peng Wang, Xiao-Yan Zhu, Ye-Hua Shen, Kun Wang, Wei-Dong Shi, Jun-Hua Lin, Zhi-Qiang Meng, Zhen Chen, Hao Chen
OBJECTIVES: This study was to evaluate the value of radiofrequency ablation (RFA) in the treatment of pancreatic cancer with synchronous liver oligometastasis. METHODS: 102 patients diagnosed with pancreatic cancer with synchronous liver oligometastasis undergoing RFA were recruited in this retrospective study between January 2012 and December 2015. Clinical efficacy was evaluated by computed tomography or magnetic resonance imaging 1 month later. All patients were treated with RFA and systemic chemotherapy based on NCCN guideline...
September 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29128882/early-recurrence-in-patients-undergoing-curative-resection-of-colorectal-liver-oligometastases-identification-of-its-clinical-characteristics-risk-factors-and-prognosis
#7
Junzhong Lin, Jianhong Peng, Yixin Zhao, Baojia Luo, Yujie Zhao, Yuxiang Deng, Qiaoqi Sui, Yuanhong Gao, Zhifan Zeng, Zhenhai Lu, Zhizhong Pan
PURPOSE: Oligometastatic disease can potentially be cured when an optimal approach is performed. Early recurrence after liver resection is an intractable problem, and the clinical implications remain unknown in colorectal liver oligometastases (CLOM) patients. This study aimed to investigate the clinical characteristics, risk factors, and prognosis related to early recurrence in these patients. METHODS: A total of 307 consecutive patients with CLOM undergoing curative liver resection were retrospectively reviewed between September 1999 and June 2016...
November 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29115903/5-year-survival-after-splenectomy-in-a-patient-with-recurrent-cutaneous-melanoma-a-case-report
#8
Lynn De Roeck, Laura Wuyts, Benjamin Peters, Martin Ruppert
OBJECTIVE: Splenic metastases of melanoma are uncommon and generally part of a disseminated disease with a poor prognosis. In case of solitary visceral metastasis, surgical resection often remains an effective treatment. This case describes a long-term survival after splenectomy for a recurrent melanoma. METHODS: We present a 55-year-old female with a solitary splenic metastasis. Her medical history revealed a melanoma of the foot in 2007 and an in-transit metastasis in 2011...
November 8, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29107278/the-role-of-local-therapy-for-oligometastatic-prostate-cancer-should-we-expect-a-cure
#9
REVIEW
Rajesh Nair, Benjamin W Lamb, Nicolas Geurts, Omar Alghazo, Wayne Lam, Nathan Lawrentschuk, Declan G Murphy
The role of local treatment in oligometastatic prostate cancer remains contentious. Treatment of the prostate in metastatic disease may confer benefit, but prospective data are lacking. With improvements in treatments, aggressive strategies directed at metastases have increasingly become of clinical interest. Current evidence suggests good local control can be achieved; however, further data are required to determine overall cancer outcomes. This article evaluates the evidence available and consider whether local treatment of oligometastatic disease is a feasible, safe, and a positive strategy in this disease cohort...
November 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29099733/effective-prostate-specific-membrane-antigen-based-18f-dcfpyl-guided-cryoablation-of-a-single-positive-site-in-a-patient-believed-to-be-more-metastatic-on-11c-choline-pet-ct
#10
Francois H Cornelis, Jeremy C Durack, Michael J Morris, Howard I Scher, Stephen B Solomon
PET/CT-guided interventions using specific radiotracers are promising for detecting avid lesions not well visualized with other imaging methods. A 72-year-old man who initially presented with prostate cancer Gleason 5 + 4 (prostate-specific antigen [PSA] = 7.9 ng/mL) underwent radical prostatectomy and node dissection. Three years after radiation, a rising PSA was observed over 6 months with PSA level reaching 1.08 ng/mL. He was evaluated with prostate-specific membrane antigen-based (PSMA) F-DCFPyL PET/CT, conventional CT, F-FDG PET/CT, and C-choline PET/CT...
December 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29098307/-therapeutic-approach-in-oligometastatic-gastric-and-esophageal-cancer
#11
REVIEW
T Schmidt, S P Mönig
The therapeutic approach to patients with oligometastatic gastric cancer and esophageal cancer is currently undergoing a shift towards a more aggressive therapy including surgical resection. In the current German S3 guidelines surgical treatment of metastatic disease is not recommended; however, nowadays interdisciplinary tumor boards have to evaluate such patients increasingly more often. On an individual basis a radical surgical resection of the primary tumor and the metastases is considered and performed in patients who respond well to multimodal chemotherapy concepts...
November 2, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29096018/massive-fatal-pulmonary-haemorrhage-during-bevacizumab-treatment-following-microwave-ablation-therapy-for-oligometastatic-lung-metastasis-from-rectal-cancer
#12
Thiru Prasanna, Greg Briggs, Sanjiv Jain, Desmond Yip
Although thoracic ablative therapies are generally safe procedures, fatal complications can occur. Bevacizumab is a standard-of-care treatment along with chemotherapy for metastatic colorectal cancer. Although uncommon, unpredictable serious adverse events can occur secondary to bevacizumab. We report a case of fatal intrapulmonary haemorrhage as a result of arteriopulmonary fistula in a patient after microwave ablation of pulmonary colorectal cancer metastasis while on bevacizumab. Antiangiogenetic properties of bevacizumab are associated with delayed wound healing, which might have been a crucial factor in the development of arteriopulmonary fistula and haemorrhage...
October 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29089122/outcomes-and-patterns-of-relapse-after-definitive-radiation-therapy-for-oligometastatic-cervical-cancer
#13
Matthew S Ning, Vamsi Ahobila, Anuja Jhingran, Shane R Stecklein, Michael Frumovitz, Kathleen M Schmeler, Patricia J Eifel, Ann H Klopp
PURPOSE: Survival rates for women with metastatic cervical cancer are low, with limited management options. Definitive radiation therapy (RT) for oligometastatic disease has led to prolonged survival in other malignancies, but this approach has yet to be systematically studied for cervical cancer. METHODS AND MATERIALS: We evaluated 38 patients who received definitive RT to oligometastatic sites of cervical cancer at a single institution from 2002 to 2015. Patients presented with synchronous (n=9) or metachronous (n=15) oligometastatic disease to supraclavicular (SCV) nodes, or with recurrent disease in mediastinum (n=10) or lung (n=7)...
October 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29066674/-treatment-strategy-in-patients-with-oligometastatic-breast-cancer
#14
Masataka Sawaki, Hiroji Iwata
Oligometastases means the state which the anatomy and physiology may limit or concentrate metastases to a single or a limited number of organs. In patients with oligometastatic breast cancer their prognosis may be good, although the impact of local therapy has not been evaluated prospectively. The development of minimally invasive surgical techniques and highly conformal ablative radiotherapy allow for safe and effective ablation of metastatic lesions in most locations. A biopsy(preferably providing histology)of a metastatic lesion has been recommended to confirm diagnosis particularly when metastasis is diagnosed for the first time...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066671/-landscape-of-lung-cancer-with-oligometastasis
#15
Yasushi Goto, Jun Sato
Lung cancer with a few to several metastases is so-called oligometastatic disease. Patient with recurrence only to limited site is also known as oligo-recurrence, and may be included as oligometastatic disease. From biological aspect, any existence of metastases is a sign of systemic disease. Due to the reports of long survival with only local treatment and without systemic disease in oligometastatic lung cancer, word of oligometastasis is used with fascinating expectation of cure to advanced lung cancer. Most of the previous reports are retrospective and no comprehensive data exists for selecting patient for local treatment to oligometastasis...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29063841/stereotactic-body-radiation-therapy-for-oligometastatic-prostate-cancer-the-hunt-for-the-silver-bullet
#16
Bridget F Koontz
No abstract text is available yet for this article.
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29033164/uk-consensus-on-normal-tissue-dose-constraints-for-stereotactic-radiotherapy
#17
G G Hanna, L Murray, R Patel, S Jain, K L Aitken, K N Franks, N van As, A Tree, P Hatfield, S Harrow, F McDonald, M Ahmed, F H Saran, G J Webster, V Khoo, D Landau, D J Eaton, M A Hawkins
Six UK studies investigating stereotactic ablative radiotherapy (SABR) are currently open. Many of these involve the treatment of oligometastatic disease at different locations in the body. Members of all the trial management groups collaborated to generate a consensus document on appropriate organ at risk dose constraints. Values from existing but older reviews were updated using data from current studies. It is hoped that this unified approach will facilitate standardised implementation of SABR across the UK and will allow meaningful toxicity comparisons between SABR studies and internationally...
October 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#18
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28994557/increasing-survival-of-metastatic-breast-cancer-through-locoregional-surgery
#19
Begoña Díaz de la Noval, Laura Frías Aldeguer, María Á Leal García, Enrique García López, Mariana Díaz Almirón, María Herrera de la Muela
BACKGROUND: Surgery for the primary tumor in metastatic breast cancer is usually not recommended, assuming that local therapy provides no advantage. Recent reports suggest a survival improvement after locoregional treatment, but this is still controversial. We aimed to evaluate the effectiveness of locoregional treatment in primary metastatic breast cancer and to determine associated factors. METHODS: A retrospective analysis of 39 women with de novo metastatic breast cancer at Hospital Universitario La Paz, from January-2012 to June-2016 grouped by locoregional treatment (n=23) or not (n=16)...
October 9, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28994422/lung-cancer-sabr-effective-against-oligometastatic-disease
#20
Peter Sidaway
No abstract text is available yet for this article.
December 2017: Nature Reviews. Clinical Oncology
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