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https://www.readbyqxmd.com/read/28343352/the-role-of-hypofractionated-radiotherapy-in-prostate-cancer
#1
REVIEW
Linus C Benjamin, Alison C Tree, David P Dearnaley
PURPOSE OF REVIEW: It is now accepted that prostate cancer has a low alpha/beta ratio, establishing a strong basis for hypofractionation of prostate radiotherapy. This review focuses on the rationale for hypofractionation and presents the evidence base for establishing moderate hypofractionation for localised disease as the new standard of care. The emerging evidence for extreme hypofractionation in managing localized and oligometastatic prostate cancer is reviewed. RECENT FINDINGS: The 5-year efficacy and toxicity outcomes from four phase III studies have been published within the last 12 months...
April 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28325637/long-term-control-of-oligometastatic-prostate-cancer-after-stereotactic-body-radiotherapy-in-the-absence-of-androgen-deprivation-therapy-a%C3%A2-case-report
#2
Mark C Markowski, Philip Imus, Jean L Wright, Douglas Schottenstein, Channing J Paller
No abstract text is available yet for this article.
February 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28314971/-when-is-surgical-treatment-indicated-in-metastatic-prostate-cancer-and-what-is-the-scientific-rationale
#3
A Kretschmer, A Herlemann, C G Stief, C Gratzke
BACKGROUND: Recent improvements in imaging diagnostics has led to a rising incidence of oligometastatic prostate cancer and, most notably, an increasing incidence of nodal-only biochemical recurrences. In this clinical setting, systemic therapy is still the treatment of choice. However, there is increasing evidence for surgical approaches in this challenging clinical setting. AIM OF THE STUDY: In this comprehensive review article, current evidence regarding surgical approaches of primary nodal metastases, nodal-only biochemical recurrence following radical prostatectomy, and osseous metastatic prostate cancer will be discussed...
March 17, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28297304/evaluation-of-kidney-motion-and-target-localization-in-abdominal-sbrt-patients
#4
Marcus Sonier, William Chu, Nafisha Lalani, Darby Erler, Patrick Cheung, Renee Korol
The purpose of this study was to evaluate bilateral kidney and target translational/rotational intrafraction motion during stereotactic body radiation therapy treatment delivery of primary renal cell carcinoma and oligometastatic adrenal lesions for patients immobilized in the Elekta BodyFIX system. Bilateral kidney motion was assessed at midplane for 30 patients immobilized in a full-body dual-vacuum-cushion system with two patients immobilized via abdominal compression. Intrafraction motion was assessed for 15 patients using kilovoltage cone-beam computed tomography (kV-CBCT) datasets (n=151) correlated to the planning CT...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296712/association-between-the-use-of-surveillance-pet-ct-and-the-detection-of-potentially-salvageable-occult-recurrences-among-patients-with-resected-high-risk-melanoma
#5
Roberto A Leon-Ferre, Lisa A Kottschade, Matthew S Block, Robert R McWilliams, Roxana S Dronca, Edward T Creagan, Jacob B Allred, Val J Lowe, Svetomir N Markovic
The optimal surveillance for patients with resected high-risk melanoma is controversial. Select locoregional or oligometastatic recurrences can be cured with salvage resection. Data on the ability of PET/CT to detect such recurrences are sparse. We evaluated whether surveillance PET/CT in patients with resected stage III-IV melanoma led to detection of clinically occult recurrences amenable to curative-intent salvage treatment. We retrospectively identified 1429 melanoma patients who underwent PET/CT between January 2008 and October 2012 at Mayo Clinic (Rochester, Minnesota)...
March 14, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28293485/a-long-term-survivor-of-metastatic-pancreatic-adenocarcinoma-free-of-recurrence-12-years-after-treatment-of-oligometastatic-disease
#6
John M Stahl, Zenta Walther, Bryan W Chang, Howard S Hochster, Kimberly L Johung
Aggressive local therapy for patients with oligometastatic pancreatic ductal adenocarcinoma (PDAC) has traditionally not been pursued due to high rates of distant progression. We describe a 62-year-old male initially presenting with resectable PDAC who underwent the Whipple procedure but developed multiple liver metastases within two months of starting adjuvant gemcitabine. Oxaliplatin was added to the regimen and complete resolution of the liver lesions resulted. He remained disease-free for five years until re-staging revealed a small lung nodule...
February 2, 2017: Curēus
https://www.readbyqxmd.com/read/28283344/-gotta-catch-em-all-or-do-we-pokemet-approach-to-metastatic-prostate-cancer
#7
EDITORIAL
Declan G Murphy, Christopher J Sweeney, Bertrand Tombal
Metastasis-directed therapy is of interest for the management of oligometastatic prostate cancer. Improved imaging may help with patient selection, but the approach to metastatic prostate cancer of "catching 'em all", or "Pokemet", must be considered experimental.
March 7, 2017: European Urology
https://www.readbyqxmd.com/read/28275501/who-are-appropriate-surgical-candidates-among-patients-with-oligometastatic-non-small-cell-lung-cancer
#8
COMMENT
Tomoyuki Hishida
No abstract text is available yet for this article.
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28275479/should-aggressive-thoracic-therapy-be-performed-in-patients-with-synchronous-oligometastatic-non-small-cell-lung-cancer-a-meta-analysis
#9
Dianhe Li, Xiaoxia Zhu, Haofei Wang, Min Qiu, Na Li
BACKGROUND: We performed a meta-analysis to compare overall survival (OS) outcomes in patients with synchronous oligometastatic non-small cell lung cancer (NSCLC) who underwent aggressive thoracic therapy (ATT) with those who did not. METHODS: A systematic review of controlled trials of ATT on survival in synchronous oligometastatic NSCLC was conducted. Hazard ratio (HR) for the main endpoint OS was pooled using a fixed-effects model. Subgroup analysis was performed in patients with single organ metastases, or with different numbers of brain metastases, or with different stages of thoracic disease...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28274491/stereotactic-body-radiotherapy-for-oligo-metastatic-liver-disease-influence-of-pre-treatment-chemotherapy-and-histology-on-local-tumor-control
#10
R J Klement, M Guckenberger, H Alheid, M Allgäuer, G Becker, O Blanck, J Boda-Heggemann, T Brunner, M Duma, S Gerum, D Habermehl, G Hildebrandt, V Lewitzki, C Ostheimer, A Papachristofilou, C Petersen, T Schneider, R Semrau, S Wachter, N Andratschke
INTRODUCTION: Stereotactic body radiation therapy (SBRT) is applied in the oligometastatic setting to treat liver metastases. However, factors influencing tumor control probability (TCP) other than radiation dose have not been thoroughly investigated. Here we set out to investigate such factors with a focus on the influence of histology and chemotherapy prior to SBRT using a large multi-center database from the German Society of Radiation Oncology. METHODS: 452 SBRT treatments in 363 patients were analyzed after collection of patient, tumor and treatment data in a multi-center database...
March 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28266145/safety-and-efficacy-of-microwave-ablation-for-medically-inoperable-colorectal-pulmonary-metastases-single-centre-experience
#11
Craig D Ferguson, Chris R Luis, Karin Steinke
INTRODUCTION: To evaluate the safety and therapeutic efficacy of percutaneous microwave ablation (MWA) for colorectal pulmonary metastases. METHODS: Retrospective review of CT-guided lung MWA at a single tertiary institution. Adverse events within 30 days of MWA were considered procedure-related complications. Imaging follow-up was with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and contrast-enhanced CT. Response of index tumours was assessed using modified response evaluation criteria in solid tumours (mRECIST)...
March 7, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28256924/outcome-appraisal-of-patients-with-limited-brain-metastases-bms-from-non-small-cell-lung-cancer-nsclc-treated-with-different-local-therapeutic-strategies-a-single-institute-evaluation
#12
Federico Pessina, Pierina Navarria, Luca Cozzi, Stefano Tomatis, Anna M Ascolese, Ciro Franzese, Luca Toschi, Armando Santoro, Fiorenza De Rose, Davide Franceschini, Lorenzo Bello, Marta Scorsetti
OBJECTIVE: To evaluate the outcome of patients with non-small-cell lung cancer (NSCLC) with limited brain metastases (BMs) treated with local approaches omitting whole-brain radiation therapy (WBRT). METHODS: Surgery was performed in case of a single, large BM, controlled extracranial disease and Karnofsky Performance Status (KPS) 90-100; stereotactic radiosurgery (SRS) or hypofractionated stereotactic radiosurgery (HSRS) was performed in all other cases. The prescribed dose was 24 Gy/1 fraction for lesions <2...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28255428/surgical-management-of-hepato-pancreatic-metastasis-from-renal-cell-carcinoma
#13
Nikolaos A Chatzizacharias, Anais Rosich-Medina, Khaled Dajani, Simon Harper, Emmanuel Huguet, Siong S Liau, Raaj K Praseedom, Asif Jah
AIM: To investigate the outcomes of liver and pancreatic resections for renal cell carcinoma (RCC) metastatic disease. METHODS: This is a retrospective, single centre review of liver and/or pancreatic resections for RCC metastases between January 2003 and December 2015. Descriptive statistical analysis and survival analysis using the Kaplan-Meier estimation were performed. RESULTS: Thirteen patients had 7 pancreatic and 7 liver resections, with median follow-up 33 mo (range: 3-98)...
February 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28246699/clinical-relevance-of-the-m1b-and-m1c-descriptors-from-the-proposed-tnm%C3%A2-8-classification-of-lung-cancer
#14
Amanda Tufman, Kathrin Kahnert, Diego Kauffmann-Guerrero, Farkhad Manapov, Katrin Milger, Ullrich Müller-Lisse, Hauke Winter, Rudolf Maria Huber, Christian Schneider
OBJECTIVE: The TNM 8 lung cancer staging system reclassifies patients with a solitary extrathoracic metastasis as M1b and two or more extrathoracic metastases as M1c. This study investigates the clinical relevance of this change. METHODS: Advanced lung cancer patients were retrospectively restaged according to the TNM8 M1b and M1c classifiers. Overall survival was compared in M1b and M1c patients staged with and without PET-CT. We then summarized the TNM 8 staging classification and the relevant literature on the treatment of oligometastatic lung cancer...
February 28, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28244413/analysis-of-factors-affecting-successful-clinical-trial-enrollment-in-the-context-of-three-prospective-randomized-controlled-trials
#15
Jennifer K Logan, Chad Tang, Zhongxing Liao, J Jack Lee, John V Heymach, Stephen G Swisher, James W Welsh, Jianjun Zhang, Steven H Lin, Daniel R Gomez
PURPOSE: Challenges can arise when attempting to maximize patient enrollment in clinical trials. There have been limited studies focusing on the barriers to enrollment and the efficacy of alternative study design to improve accrual. We analyzed barriers to clinical trial enrollment, particularly the influence of timing, in context of three prospective, randomized oncology trials where one arm was considered more aggressive than the other. METHODS AND MATERIALS: From June 2011 to March 2015, patients who were enrolled on 3 prospective institutional protocols (an oligometastatic non-small cell lung cancer [NSCLC] trial and 2 proton vs intensity modulated radiation therapy trials in NSCLC and esophageal cancer) were screened for protocol eligibility...
March 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#16
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28236204/-consolidative-local-therapy-in-oligometastatic-nsclc-without-progression-after-first-line-chemotherapy
#17
Daniel Buergy, Frederik Wenz
No abstract text is available yet for this article.
April 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28225434/pet-ct-surveillance-detects-asymptomatic-recurrences-in-stage-iiib-and-iiic-melanoma-patients-a-prospective-cohort-study
#18
Max F Madu, Pieter Timmerman, Michel W J M Wouters, Bernies van der Hiel, Jos A van der Hage, Alexander C J van Akkooi
AJCC stage IIIB and IIIC melanoma patients are at risk for disease relapse or progression. The advent of effective systemic therapies has made curative treatment of progressive disease a possibility. As resection of oligometastatic disease can confer a survival benefit and as immunotherapy is possibly most effective in a low tumor load setting, there is a likely benefit to early detection of progression. The aim of this pilot study was to evaluate a PET/computed tomography (CT) surveillance schedule for resected stage IIIB and IIIC melanoma...
February 20, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28215455/lung-ablation-best-practice-results-response-assessment-role-alongside-other-ablative-therapies
#19
REVIEW
T de Baere, L Tselikas, G Gravel, F Deschamps
Today, in addition to surgery, other local therapies are available for patients with small-size non-small-cell lung cancer (NSCLC) and oligometastatic disease from various cancers. Local therapies include stereotactic ablation radiotherapy (SABR) and thermal ablative therapies through percutaneously inserted applicators. Although radiofrequency ablation (RFA) has been explored in series with several hundreds of patients with pulmonary tumours, investigation of the potential of other ablation technologies including microwave ablation, cryoablation, and irreversible electroporation is ongoing...
February 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28213624/oligometastatic-colorectal-cancer-is-single-site-bony-colorectal-metastasis-a-treatable-condition
#20
Noel Cassar, Adrian Ben Cresswell, Brendan Moran
INTRODUCTION: A potentially resectable bony metastasis in the context of oligometastatic colorectal cancer is uncommon. Bony metastases are usually considered a late event with poor prognosis and generally associated with liver and/or lung metastases. INDEX CASE: A previously healthy 33-year-old gentleman, with no family history of colorectal cancer, presented with rectal bleeding and at colonoscopy had a biopsy-proven adenocarcinoma of the rectum, 7 cm from the anal verge...
February 17, 2017: International Journal of Colorectal Disease
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