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https://www.readbyqxmd.com/read/29456546/genome-wide-association-studies-and-comparison-of-models-and-cross-validation-strategies-for-genomic-prediction-of-quality-traits-in-advanced-winter-wheat-breeding-lines
#1
Peter S Kristensen, Ahmed Jahoor, Jeppe R Andersen, Fabio Cericola, Jihad Orabi, Luc L Janss, Just Jensen
The aim of the this study was to identify SNP markers associated with five important wheat quality traits (grain protein content, Zeleny sedimentation, test weight, thousand-kernel weight, and falling number), and to investigate the predictive abilities of GBLUP and Bayesian Power Lasso models for genomic prediction of these traits. In total, 635 winter wheat lines from two breeding cycles in the Danish plant breeding company Nordic Seed A/S were phenotyped for the quality traits and genotyped for 10,802 SNPs...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29453652/significance-of-the-nonneoplastic-renal-parenchymal-findings-in-robotic-partial-nephrectomy-series
#2
Ercan Malkoç, Matthew J Maurice, Oktay Akça, Önder Kara, Homayoun Zargar, Hiury Andrade, Daniel Ramirez, Peter Caputo, Robert Stein, Demirjian Sevag, Jihad H Kaouk
AIM: To describe the pathological characteristics of the peritumoral non-neoplastic renal parenchyma (NNRP) and to investigate their impact on long-term renal function after partial nephrectomy. MATERIALS AND METHODS: In our institutional robotic partial nephrectomy database, we identified 394 cases with pathological assessment of the NNRP and long-term postoperative renal functional follow-up. The NNRP was classified as normal (healthy renal parenchyma) or abnormal, based on the presence of arteriosclerosis, glomerulosclerosis, interstitial fibrosis, interstitial inflammation, and/or tubulopapillary hyperplasia...
February 16, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29439991/study-of-dna-translocases-in-bacillus-subtilis-by-single-molecule-tracking-reveals-strikingly-different-dynamics-of-sfta-spoiiie-and-ftsa
#3
Nina El Najjar, Jihad El Andari, Christine Kaimer, Georg Fritz, Thomas C Rösch, Peter L Graumann
Like many bacteria, Bacillus subtilis possesses two DNA translocases that affect chromosome segregation at different steps. Prior to septum closure, non-segregated DNA is moved into opposite cell halves by SftA, while septum-entrapped DNA is rescued by SpoIIIE. We have used single molecule microscopy (SMT) experiments to describe the dynamics of the two different DNA translocases, cell division protein FtsA, and glycolytic enzyme PfkA, in real time. SMT revealed that about 30% of SftA molecules move through the cytosol, while a fraction of 70% is septum-bound and static...
February 9, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29433878/the-effect-of-resident-involvement-on-bariatric-surgical-outcomes-an-acs-nsqip-analysis
#4
Ivy N Haskins, Jihad Kudsi, Kathleen Hayes, Richard L Amdur, Paul P Lin, Khashayar Vaziri
BACKGROUND: Surgical residency training programs in the United States are modeled on the principle of graduated responsibility. Residents are given greater responsibility and autonomy in the operating room and during perioperative care as they gain surgical skills and progress through their training. The impact of this method of surgical training on patient outcomes remains unknown. The purpose of this study is to compare early patient morbidity and mortality after bariatric surgery in cases with and without resident participation using the American College of Surgeons National Surgical Quality Improvement Program database...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29409061/child-labor-and-health-a-systematic-literature-review-of-the-impacts-of-child-labor-on-child-s-health-in-low-and-middle-income-countries
#5
Abdalla Ibrahim, Salma M Abdalla, Mohammed Jafer, Jihad Abdelgadir, Nanne de Vries
Objective: To summarize current evidence on the impacts of child labor on physical and mental health. Methods: We searched PubMed and ScienceDirect for studies that included participants aged 18 years or less, conducted in low- and middle-income countries (LMICs), and reported quantitative data. Two independent reviewers conducted data extraction and assessment of study quality. Results: A total of 25 studies were identified, the majority of which were cross-sectional...
February 2, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29352227/ly2087101-and-dfbr-share-transmembrane-binding-sites-in-the-%C3%AE-4-3-%C3%AE-2-2-nicotinic-acetylcholine-receptor
#6
Farah Deba, Hamed I Ali, Abisola Tairu, Kara Ramos, Jihad Ali, Ayman K Hamouda
Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChRs) have potential therapeutic application in neuropathologies associated with decrease in function or loss of nAChRs. In this study, we characterize the pharmacological interactions of the nAChRs PAM, LY2087101, with the α4β2 nAChR using mutational and computational analyses. LY2087101 potentiated ACh-induced currents of low-sensitivity (α4)3(β2)2 and high-sensitivity (α4)2(β2)3 nAChRs with similar potencies albeit to a different maximum potentiation (potentiation I max  = ~840 and 450%, respectively)...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336977/the-role-of-extended-venous-thromboembolism-prophylaxis-following-urologic-pelvic-surgery
#7
Daniel Sagalovich, Rollin Say, Jihad Kaouk, Reza Mehrazin
With the emergence of evidence that venous thromboembolisms (VTE) typically occurs following discharge after urologic pelvic surgery, the focus on extended VTE prophylaxis has intensified. Urologists should have a comprehensive understanding of various VTE risk factors in order to weigh the risk of postoperative hemorrhage with the possibility of fatal pulmonary embolus. Risk factors such as advanced age, obesity, and active malignancy are especially common in patient's undergoing urologic pelvic surgery, and thus this issue becomes particularly relevant to the practicing urologist...
January 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29326371/mycoplasma-pneumoniae-infection-presenting-as-stroke-and-meningoencephalitis-with-aortic-and-subclavian-aneurysms-without-pulmonary-involvement
#8
Pournamy Sarathchandran, Abubaker Al Madani, Ayman M Alboudi, Jihad Inshasi
A 39-year-old Philipino man presented with acute onset fever and headache. Neurological examination was normal except for neck stiffness. There was no history of chest pain, cough or breathlessness. Cerebrospinal fluid (CSF) showed a mild increase in protein with normal sugar and lymphocytic pleocytosis. CSF PCR for herpes simplex and varicella zoster virus was negative. He developed acute right haemiplegia a week after hospitalisation. MRI showed acute infarct in the left centrum semiovale. His angiogram showed aneurysm in the left subclavian artery and aortic arch...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29275112/outcomes-of-intracorporeal-urinary-diversion-after-robot-assisted-radical-cystectomy-results-from-the-international-robotic-cystectomy-consortium
#9
Ahmed A Hussein, Paul R May, Zhe Jing, Youssef E Ahmed, Carl J Wijburg, Abdulla Erdem Canda, Prokar Dasgupta, Mohammad Shamim Khan, Mani Menon, James O Peabody, Abolfazl Hosseini, John Kelly, Alexandre Mottrie, Jihad Kaouk, Ashok Hemal, Peter Wiklund, Khurshid A Guru, Andrew Wagner, Matthias Saar, Joan Palou Redorta, Michael Stockle, Lee Richstone, Franco Gaboardi, Ketan Badani, Koon-Ho Rha, Hijab Khan, Omar Kawa, Francis Schanne, Vassilis Polakis, Alon Weizer, Douglas Scherr, Giovannalberto Pini, Wei Shen Tan, Thomas J Maatman, Adam Kibel, Bertram Yuh, Taylor C Peak
INTRODUCTION AND OBJECTIVE: This study aims to provide an update and compare perioperative outcomes and complications of Intracorporeal urinary diversion (ICUD) and extracorporeal urinary diversion (ECUD) following RARC from a multi-institutional, prospectively maintained database, the International Robotic Cystectomy Consortium (IRCC). METHODS: A retrospective review of 2125 patients from 26 institutions was performed. ICUD was compared with ECUD Multivariate (stepwise variable selection) logistic regression models were fit to evaluate preoperative, operative, and postoperative predictors of receiving ICUD, operative time, high grade complications and 90-days readmissions after RARC...
December 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29273706/delayed-diagnosis-of-ureteral-injury-following-penetrating-abdominal-trauma-a-case-report-and-review-of-the-literature
#10
Kadhim M Taqi, Manar Mohammed Nassr, Jihad Salim Al Jufaili, Alla Ibrahim Abu-Qasida, Joseph Mathew, Hani Al-Qadhi
BACKGROUND Ureteral injuries are considered to be uncommon in cases of trauma. The possibility of damage to the ureters may not be considered in the setting of acute trauma when life-threatening injuries take clinical management priority. A case of acute ureteral injury is described in a patient with acute penetrating gunshot abdominal injury that had a delay in diagnosis, with a review of the literature. CASE REPORT A 29-year-old woman presented to our hospital with a missed ureteral injury following a self-inflicted gunshot injury to the abdomen...
December 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29233163/intra-articular-injection-of-expanded-autologous-bone-marrow-mesenchymal-cells-in-moderate-and-severe-knee-osteoarthritis-is-safe-a-phase-i-ii-study
#11
Mahasen Al-Najar, Hiba Khalil, Jihad Al-Ajlouni, Eman Al-Antary, Mohammad Hamdan, Reem Rahmeh, Dana Alhattab, Osama Samara, Mohamad Yasin, Amenah Al Abdullah, Esraa Al-Jabbari, Dima Hmaid, Hanan Jafar, Abdalla Awidi
BACKGROUND: Knee osteoarthritis (KOA) is a major health problem especially in the aging population. There is a need for safe treatment that restores the cartilage and reduces the symptoms. The use of stem cells is emerging as a possible option for the moderate and severe cases. This study aimed at testing the safety of autologous bone marrow mesenchymal stem cells (BM-MSCs) expanded in vitro when given intra-articularly to patients with stage II and III KOA. As a secondary end point, the study tested the ability of these cells to relieve symptoms and restore the knee cartilage in these patients as judged by normalized knee injury and Osteoarthritis Outcome Score (KOOS) and by magnetic resonance imaging (MRI)...
December 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29229808/impact-of-insecticide-resistance-in-anopheles-arabiensis-on-malaria-incidence-and-prevalence-in-sudan-and-the-costs-of-mitigation
#12
Hmooda Toto Kafy, Bashir Adam Ismail, Abraham Peter Mnzava, Jonathan Lines, Mogahid Shiekh Eldin Abdin, Jihad Sulieman Eltaher, Anuar Osman Banaga, Philippa West, John Bradley, Jackie Cook, Brent Thomas, Krishanthi Subramaniam, Janet Hemingway, Tessa Bellamy Knox, Elfatih M Malik, Joshua O Yukich, Martin James Donnelly, Immo Kleinschmidt
Insecticide-based interventions have contributed to ∼78% of the reduction in the malaria burden in sub-Saharan Africa since 2000. Insecticide resistance in malaria vectors could presage a catastrophic rebound in disease incidence and mortality. A major impediment to the implementation of insecticide resistance management strategies is that evidence of the impact of resistance on malaria disease burden is limited. A cluster randomized trial was conducted in Sudan with pyrethroid-resistant and carbamate-susceptible malaria vectors...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29208561/antibacterial-prophylaxis-with-ciprofloxacin-for-patients-with-multiple-myeloma-and-lymphoma-undergoing-autologous-haematopoietic-cell-transplantation-a-quasi-experimental-single-centre-before-after-study
#13
M Yeshurun, I Vaxman, L Shargian, D Yahav, J Bishara, O Pasvolsky, O Wolach, M Lahav, R Gurion, H Magen, L Vidal, C Herscovici, A Peck, M Moshe, M Sela-Navon, E Naparstek, P Raanani, U Rozovski
OBJECTIVES: We aimed to study whether ciprofloxacin prophylaxis reduces infectious complications in patients undergoing autologous haematopoietic cell transplantation (AHCT). METHODS: This is a quasi-experimental, retrospective, before-after study. We compared the incidence of bacterial-related complications among 356 patients with multiple myeloma (MM) (n = 202) and lymphoma (n = 154) who underwent AHCT with (n = 177) or without (n = 179) ciprofloxacin prophylaxis between 03/2007 and 10/2012 and between 10/2012 and 07/2016, respectively, at a single centre...
December 6, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29207364/transpedal-access-for-the-management-of-complex-peripheral-artery-disease
#14
Konstantinos Marmagkiolis, Partha Sardar, Jihad A Mustapha, Miguel Montero-Baker, Konstantinos Charitakis, Cezar Iliescu, Dmitriy N Feldman
OBJECTIVES: To evaluate the safety and efficacy of transpedal access for the management of complex peripheral artery disease (PAD). INTRODUCTION: Critical limb ischemia is associated with high risk of limb loss, as well as cardiovascular and all-cause mortality. Transpedal access is a novel, increasingly utilized technique for the management of complex PAD. METHODS: We performed a literature search using PubMed from January 2003 to December 2016...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29184565/a-novel-qtl-for-powdery-mildew-resistance-in-nordic-spring-barley-hordeum-vulgare-l-ssp-vulgare-revealed-by-genome-wide-association-study
#15
Therése Bengtsson, Inger Åhman, Outi Manninen, Lars Reitan, Therese Christerson, Jens Due Jensen, Lene Krusell, Ahmed Jahoor, Jihad Orabi
The powdery mildew fungus, Blumeria graminis f. sp. hordei is a worldwide threat to barley (Hordeum vulgare L. ssp. vulgare) production. One way to control the disease is by the development and deployment of resistant cultivars. A genome-wide association study was performed in a Nordic spring barley panel consisting of 169 genotypes, to identify marker-trait associations significant for powdery mildew. Powdery mildew was scored during three years (2012-2014) in four different locations within the Nordic region...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29181170/role-of-kr%C3%A3-ppel-like-factor-4-and-heat-shock-protein-27-in-cancer-of-the-larynx
#16
Jihad Karam, Marie Claude Fadous-Khalifé, Rita Tannous, Sally Fakhreddine, Marcel Massoud, Joseph Hadchity, Georges Aftimos, Elie Hadchity
Late detection and lack of standard treatment strategies in larynx cancer patients result in high levels of mortality and poor prognosis. Prognostic stratification of larynx cancer patients based on molecular prognostic tumor biomarkers may lead to more efficient clinical management. Krüppel-like factor 4 (KLF4) and Heat Shock Protein 27 (HSP27) have an important role in tumorigenesis and are considered promising candidate biomarkers for various types of cancer. However, their role in larynx carcinoma remains to be elucidated...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29174943/use-of-99mtc-sestamibi-single-photon-emission-computed-tomography-x-ray-computed-tomography-in-the-diagnosis-of-hybrid-oncocytic-chromophobe-tumor-in-a-pediatric-patient
#17
Nima Almassi, Michael A Gorin, Andrei S Purysko, Steven P Rowe, Jihad Kaouk, Mohamad E Allaf, Steven C Campbell, Audrey Rhee
The differential diagnosis of solid renal neoplasms in adolescence includes aggressive malignancy and indolent oncocytic tumors, which are typically indistinguishable using conventional imaging. We report the use of 99mTc-sestamibi single-photon emission computed tomography / x-ray computed tomography (SPECT/CT) in characterizing enhancing renal neoplasms in a pediatric patient. Genetic testing suggested a hereditary syndrome associated with aggressive malignancy, whereas renal mass biopsy suggested an oncocytic tumor...
November 23, 2017: Urology
https://www.readbyqxmd.com/read/29174822/acute-procedural-outcomes-of-orbital-atherectomy-for-the-treatment-of-iliac-artery-disease-sub-analysis-of-the-confirm-registries
#18
Michael S Lee, Brad J Martinsen, John Hollowed, Daniel Heikali, Jihad Mustapha, George Adams, Ehtisham Mahmud
Endovascular intervention is an appealing revascularization strategy for iliac artery disease. Atherectomy of the iliac artery is uncommon due to the risk of life-threatening perforation but may be necessary if the iliac lesion is heavily calcified, preventing stent delivery or optimal expansion. We assessed the feasibility and safety of orbital atherectomy for the treatment of iliac artery disease. Demographic data, lesion characteristics, and procedure outcomes for the CONFIRM patients with at least one iliac artery lesion treated with orbital atherectomy (n=62 patients; n=68 lesions) were compared to patients with at least one superficial femoral artery (SFA) lesion treated with orbital atherectomy (n=1570 patients; n=1809 lesions)...
October 27, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29154041/patient-characteristics-treatment-patterns-and-prognostic-factors-in-squamous-cell-bladder-cancer
#19
Haris Zahoor, Paul Elson, Andrew Stephenson, Georges-Pascal Haber, Jihad Kaouk, Amr Fergany, Byron Lee, Vadim Koshkin, Moshe Ornstein, Timothy Gilligan, Jorge A Garcia, Brian Rini, Petros Grivas
BACKGROUND: Squamous cell carcinoma (SCC) is an uncommon histologic subtype of bladder cancer with limited data on treatment patterns, outcomes, and prognostic factors. "Real world" information might inform decision-making, prognostic estimates, and clinical trial designs. PATIENTS AND METHODS: A retrospective review of patients with tissue-confirmed bladder SCC treated at Cleveland Clinic from 2007 to 2016 was performed. Data on patient characteristics, treatment patterns, and clinical follow-up were extracted...
October 17, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29066002/pediatric-traumatic-brain-injury-at-mbarara-regional-referral-hospital-uganda
#20
Jihad Abdelgadir, Maria Punchak, Emily R Smith, Aaron Tarnasky, Alex Muhindo, Joao Ricardo Nickenig Vissoci, Michael M Haglund, David Kitya
BACKGROUND: In Uganda, TBI constitute the majority of neurosurgical admissions and deaths specially in the pediatric population. This study aims to determine the factors associated with poor outcome among pediatric TBI cases at a major referral hospital in western Uganda. METHODS: This study was conducted at Mbarara Regional Referral Hospital (MRRH) in western Uganda. All pediatric neurosurgical cases between 2012 and 2015 were reviewed. In-hospital mortality and discharge GCS were the main outcomes of interest...
October 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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