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https://www.readbyqxmd.com/read/29233163/intra-articular-injection-of-expanded-autologous-bone-marrow-mesenchymal-cells-in-moderate-and-severe-knee-osteoarthritis-is-safe-a-phase-i-ii-study
#1
Mahasen Al-Najar, Hiba Khalil, Jihad Al-Ajlouni, Eman Al-Antary, Mohammad Hamdan, Reem Rahmeh, Dana Alhattab, Osama Samara, Mohamad Yasin, Amenah Al Abdullah, Esraa Al-Jabbari, Dima Hmaid, Hanan Jafar, Abdalla Awidi
BACKGROUND: Knee osteoarthritis (KOA) is a major health problem especially in the aging population. There is a need for safe treatment that restores the cartilage and reduces the symptoms. The use of stem cells is emerging as a possible option for the moderate and severe cases. This study aimed at testing the safety of autologous bone marrow mesenchymal stem cells (BM-MSCs) expanded in vitro when given intra-articularly to patients with stage II and III KOA. As a secondary end point, the study tested the ability of these cells to relieve symptoms and restore the knee cartilage in these patients as judged by normalized knee injury and Osteoarthritis Outcome Score (KOOS) and by magnetic resonance imaging (MRI)...
December 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29229808/impact-of-insecticide-resistance-in-anopheles-arabiensis-on-malaria-incidence-and-prevalence-in-sudan-and-the-costs-of-mitigation
#2
Hmooda Toto Kafy, Bashir Adam Ismail, Abraham Peter Mnzava, Jonathan Lines, Mogahid Shiekh Eldin Abdin, Jihad Sulieman Eltaher, Anuar Osman Banaga, Philippa West, John Bradley, Jackie Cook, Brent Thomas, Krishanthi Subramaniam, Janet Hemingway, Tessa Bellamy Knox, Elfatih M Malik, Joshua O Yukich, Martin James Donnelly, Immo Kleinschmidt
Insecticide-based interventions have contributed to ∼78% of the reduction in the malaria burden in sub-Saharan Africa since 2000. Insecticide resistance in malaria vectors could presage a catastrophic rebound in disease incidence and mortality. A major impediment to the implementation of insecticide resistance management strategies is that evidence of the impact of resistance on malaria disease burden is limited. A cluster randomized trial was conducted in Sudan with pyrethroid-resistant and carbamate-susceptible malaria vectors...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29208561/antibacterial-prophylaxis-with-ciprofloxacin-for-patients-with-multiple-myeloma-and-lymphoma-undergoing-autologous-haematopoietic-cell-transplantation-a-quasi-experimental-single-centre-before-after-study
#3
Moshe Yeshurun, Iuliana Vaxman, Liat Shargian, Dafna Yahav, Jihad Bashara, Oren Pasvolski, Ofir Wolach, Meir Lahav, Ronit Gurion, Hila Magen, Liat Vidal, Corina Herscovici, Anat Peck, Maya Moshe, Michal Sela Navon, Elizabeth Naparstek, Pia Raanani, Uri Rozovski
OBJECTIVES: We aimed to study whether ciprofloxacin prophylaxis reduces infectious complications in patients undergoing autologous haematopoietic cell transplantation (AHCT). METHODS: This is a quasi-experimental, retrospective, before-after study. We compared the incidence of bacterial related complications among 356 patients with multiple myeloma (MM) (n=202) and lymphoma (n=154) who underwent AHCT with (n=177) or without (n=179) ciprofloxacin prophylaxis between 03/2007-10/2012 and between 10/2012-07/2016, respectively at a single centre...
December 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29207364/transpedal-access-for-the-management-of-complex-peripheral-artery-disease
#4
Konstantinos Marmagkiolis, Partha Sardar, Jihad A Mustapha, Miguel Montero-Baker, Konstantinos Charitakis, Cezar Iliescu, Dmitriy N Feldman
OBJECTIVES: To evaluate the safety and efficacy of transpedal access for the management of complex peripheral artery disease (PAD). INTRODUCTION: Critical limb ischemia is associated with high risk of limb loss, as well as cardiovascular and all-cause mortality. Transpedal access is a novel, increasingly utilized technique for the management of complex PAD. METHODS: We performed a literature search using PubMed from January 2003 to December 2016...
December 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29184565/a-novel-qtl-for-powdery-mildew-resistance-in-nordic-spring-barley-hordeum-vulgare-l-ssp-vulgare-revealed-by-genome-wide-association-study
#5
Therése Bengtsson, Inger Åhman, Outi Manninen, Lars Reitan, Therese Christerson, Jens Due Jensen, Lene Krusell, Ahmed Jahoor, Jihad Orabi
The powdery mildew fungus, Blumeria graminis f. sp. hordei is a worldwide threat to barley (Hordeum vulgare L. ssp. vulgare) production. One way to control the disease is by the development and deployment of resistant cultivars. A genome-wide association study was performed in a Nordic spring barley panel consisting of 169 genotypes, to identify marker-trait associations significant for powdery mildew. Powdery mildew was scored during three years (2012-2014) in four different locations within the Nordic region...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29181170/role-of-kr%C3%A3-ppel-like-factor-4-and-heat-shock-protein-27-in-cancer-of-the-larynx
#6
Jihad Karam, Marie Claude Fadous-Khalifé, Rita Tannous, Sally Fakhreddine, Marcel Massoud, Joseph Hadchity, Georges Aftimos, Elie Hadchity
Late detection and lack of standard treatment strategies in larynx cancer patients result in high levels of mortality and poor prognosis. Prognostic stratification of larynx cancer patients based on molecular prognostic tumor biomarkers may lead to more efficient clinical management. Krüppel-like factor 4 (KLF4) and Heat Shock Protein 27 (HSP27) have an important role in tumorigenesis and are considered promising candidate biomarkers for various types of cancer. However, their role in larynx carcinoma remains to be elucidated...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29174943/use-of-99mtc-sestamibi-spect-ct-in-the-diagnosis-of-hybrid-oncocytic-chromophobe-tumor-in-a-pediatric-patient
#7
Nima Almassi, Michael A Gorin, Andrei Purysko, Steven P Rowe, Jihad Kaouk, Mohamad E Allaf, Steven C Campbell, Audrey Rhee
The differential diagnosis of solid renal neoplasms in adolescence includes aggressive malignancy and indolent oncocytic tumors which are typically indistinguishable using conventional imaging. We report use of 99mTc-sestamibi single photon emission computed tomography/x-ray computed tomography (SPECT/CT) in characterizing enhancing renal neoplasms in a pediatric patient. Genetic testing suggested a hereditary syndrome associated with aggressive malignancy, while renal mass biopsy suggested an oncocytic tumor...
November 23, 2017: Urology
https://www.readbyqxmd.com/read/29174822/acute-procedural-outcomes-of-orbital-atherectomy-for-the-treatment-of-iliac-artery-disease-sub-analysis-of-the-confirm-registries
#8
Michael S Lee, Brad J Martinsen, John Hollowed, Daniel Heikali, Jihad Mustapha, George Adams, Ehtisham Mahmud
Endovascular intervention is an appealing revascularization strategy for iliac artery disease. Atherectomy of the iliac artery is uncommon due to the risk of life-threatening perforation but may be necessary if the iliac lesion is heavily calcified, preventing stent delivery or optimal expansion. We assessed the feasibility and safety of orbital atherectomy for the treatment of iliac artery disease. Demographic data, lesion characteristics, and procedure outcomes for the CONFIRM patients with at least one iliac artery lesion treated with orbital atherectomy (n=62 patients; n=68 lesions) were compared to patients with at least one superficial femoral artery (SFA) lesion treated with orbital atherectomy (n=1570 patients; n=1809 lesions)...
October 27, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29154041/patient-characteristics-treatment-patterns-and-prognostic-factors-in-squamous-cell-bladder-cancer
#9
Haris Zahoor, Paul Elson, Andrew Stephenson, Georges-Pascal Haber, Jihad Kaouk, Amr Fergany, Byron Lee, Vadim Koshkin, Moshe Ornstein, Timothy Gilligan, Jorge A Garcia, Brian Rini, Petros Grivas
BACKGROUND: Squamous cell carcinoma (SCC) is an uncommon histologic subtype of bladder cancer with limited data on treatment patterns, outcomes, and prognostic factors. "Real world" information might inform decision-making, prognostic estimates, and clinical trial designs. PATIENTS AND METHODS: A retrospective review of patients with tissue-confirmed bladder SCC treated at Cleveland Clinic from 2007 to 2016 was performed. Data on patient characteristics, treatment patterns, and clinical follow-up were extracted...
October 17, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29066002/pediatric-traumatic-brain-injury-at-mbarara-regional-referral-hospital-uganda
#10
Jihad Abdelgadir, Maria Punchak, Emily R Smith, Aaron Tarnasky, Alex Muhindo, Joao Ricardo Nickenig Vissoci, Michael M Haglund, David Kitya
BACKGROUND: In Uganda, TBI constitute the majority of neurosurgical admissions and deaths specially in the pediatric population. This study aims to determine the factors associated with poor outcome among pediatric TBI cases at a major referral hospital in western Uganda. METHODS: This study was conducted at Mbarara Regional Referral Hospital (MRRH) in western Uganda. All pediatric neurosurgical cases between 2012 and 2015 were reviewed. In-hospital mortality and discharge GCS were the main outcomes of interest...
October 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29057261/aprepitant-for-the-treatment-of-chronic-refractory-pruritus
#11
REVIEW
Alice He, Jihad M Alhariri, Ronald J Sweren, Madan M Kwatra, Shawn G Kwatra
Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Aprepitant is a neurokinin-1 receptor antagonist approved for the prevention of chemotherapy-induced and postoperative nausea and vomiting (CINV, PONV)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29019893/rescue-therapeutic-strategy-combining-ultra-protective-mechanical-ventilation-with-extracorporeal-co2-removal-membrane-in-near-fatal-asthma-with-severe-pulmonary-barotraumas-a-case-report
#12
Arthur Pavot, Jihad Mallat, Nicolas Vangrunderbeeck, Didier Thevenin, Malcolm Lemyze
RATIONALE: Mechanical ventilation of severe acute asthma is still considered a challenging issue, mainly because of the gas trapping phenomenon with the potential for life-threatening barotraumatic pulmonary complications. PATIENT CONCERNS: Herein, we describe 2 consecutive cases of near-fatal asthma for whom the recommended protective mechanical ventilation approach using low tidal volume of 6 mL/kg and small levels of PEEP was rapidly compromised by giant pneumomediastinum with extensive subcutaneousemphysema...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984094/mucosal-and-cutaneous-capnometry-for-the-assessment-of-tissue-hypoperfusion
#13
Jihad Mallat, Benoit Vallet
In critically ill patients, tissue hypoperfusion is an important cause leading to multi- organ dysfunction and death, and it cannot always be detected by measuring standard global hemodynamic and oxygen-derived parameters. Gastric intramucosal PCO2 as measured by gastric tonometry has been recognized to be of clinical value as a prognostic factor, in assessing the effects of particular therapeutic interventions, and as an end-point of resuscitation. However, this technique has several limitations that have hampered its implementation in clinical practice...
October 4, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28982624/robotic-retrocaval-metastasectomy-after-an-ipsilateral-radical-nephrectomy
#14
Ryan J Nelson, Jeremy H Reese, Paurush Babbar, Jihad H Kaouk
OBJECTIVE: Robotic management of a retrocaval metastasis can be challenging because of prior surgery leading to scarring and obscure surgical planes around vital structures. We present our robotic approach and technique to manage a large retrocaval, biopsy-proven, metastatic mass after previous laparoscopic right radical nephrectomy with concomitant adrenalectomy 10 years ago. METHODS: We present a 62-year-old man who previously underwent a laparoscopic right radical nephrectomy for pT1bNxMx chromophobe renal cell carcinoma (RCC) in 2007...
September 2017: Urology
https://www.readbyqxmd.com/read/28982623/robotic-radical-left-nephrectomy-with-inferior-vena-cava-level-iii-thrombectomy
#15
Ryan J Nelson, Matthew J Maurice, Jihad H Kaouk
INTRODUCTION AND OBJECTIVE: We present our robotic approach and technique to manage a large left renal tumor with inferior vena cava (IVC) Level III thrombus. The superior mesenteric artery crossing the left renal vein requires robotic docking from the left, for dissection of the left kidney followed by repositioning and re-docking the robot from the right side for dissection of the right renal vein, distal and proximal IVC, and the remaining left renal vein insertion into the IVC. METHODS: We present a 53-year-old man with a 10...
September 2017: Urology
https://www.readbyqxmd.com/read/28942734/adult-langerhans-cell-histiocytosis-with-pulmonary-and-colorectoanal-involvement-a-case-report
#16
Mohamad Jihad Mansour, Elias Mokbel, Eddy Fares, Janah Maddah, Fadi Nasr
BACKGROUND: Langerhans cell histiocytosis is a rare systemic disease characterized by the abnormal overproduction of histiocytes that tend to infiltrate single or multiple organ systems leading to significant tissue damage. It mainly affects - by order of decreasing frequency - the bone, the skin, the lymph nodes, the liver, and lungs. Gastrointestinal tract involvement is extremely rare in adults. CASE PRESENTATION: We describe the case of a 32-year-old Middle Eastern man with Langerhans cell histiocytosis involving his lungs and the colorectoanal part of his gastrointestinal tract, with complete resolution of gastrointestinal tract lesions following a non-standardized chemotherapy regimen...
September 25, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28925997/precision-annotation-of-digital-samples-in-ncbi-s-gene-expression-omnibus
#17
Dexter Hadley, James Pan, Osama El-Sayed, Jihad Aljabban, Imad Aljabban, Tej D Azad, Mohamad O Hadied, Shuaib Raza, Benjamin Abhishek Rayikanti, Bin Chen, Hyojung Paik, Dvir Aran, Jordan Spatz, Daniel Himmelstein, Maryam Panahiazar, Sanchita Bhattacharya, Marina Sirota, Mark A Musen, Atul J Butte
The Gene Expression Omnibus (GEO) contains more than two million digital samples from functional genomics experiments amassed over almost two decades. However, individual sample meta-data remains poorly described by unstructured free text attributes preventing its largescale reanalysis. We introduce the Search Tag Analyze Resource for GEO as a web application (http://STARGEO.org) to curate better annotations of sample phenotypes uniformly across different studies, and to use these sample annotations to define robust genomic signatures of disease pathology by meta-analysis...
September 19, 2017: Scientific Data
https://www.readbyqxmd.com/read/28914972/seasonal-patterns-of-acute-and-recurrent-idiopathic-pericarditis
#18
Yoav Hammer, Jihad Bishara, Alon Eisen, Zaza Iakobishvili, Ran Kornowski, Aviv Mager
BACKGROUND: Idiopathic pericarditis is presumed to result from viral infection. The incidence rates of some viral infections have typical seasonal patterns. The data in the literature on a possible seasonal pattern of acute pericarditis are very limited. The mechanism and possible seasonality of recurrent episodes are not well established . HYPOTHESIS: The incidence of acute idiopathic pericarditis has a seasonal pattern. METHODS: The computerized database of a tertiary, university-affiliated hospital was searched for all patients admitted with a first episode of acute idiopathic pericarditis between January 1, 2010 and December 31, 2015...
September 15, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28905673/the-practice-of-research-ethics-in-lebanon-and-qatar-perspectives-of-researchers-on-informed-consent
#19
Rima Nakkash, Yara Qutteina, Catherine Nasrallah, Katharine Wright, Leila El-Alti, Jihad Makhoul, Khalid Al-Ali
Informed consent requirements for conducting research with human participants are set by institutional review boards (IRBs) following established guidelines. Despite this, researchers continue to face challenges in seeking and obtaining informed consent. This study discusses researchers' views of such problems in Lebanon and Qatar, which vary in research regulation. We conducted in-depth interviews with 52 academic researchers from various fields of research in both countries and analyzed them using thematic analysis...
September 1, 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28904671/-idiopathic-intracranial-hypertension-a-rare-case-related-to-pregnancy
#20
Jihad Drissi, Ayman Hachi, Laila Adlani, Jaouad Kouach, Driss Moussaoui, Mohamed Dehayni
We report the case of a 25-year old primipara whose pregnancy was complicated by idiopathic intracranial hypertension (ICHT) associated with visual impairment in the first quarter. She underwent lumboperitoneal shunt without obstetric consequences. This study aimed to determine the features of this rare pathological entity whose pathophysiological mechanism is poorly elucidated. It would be caused by poor absorption of cerebrospinal fluid (CSF) through the arachnoid granulations. Major risk factors are: obesity, polycystic ovary syndrome, thrombophilia and hyperfibrinolyse...
2017: Pan African Medical Journal
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