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menopause and multiple sclerosis

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https://www.readbyqxmd.com/read/27749097/interferon-beta-1b-induced-postmenopausal-bleeding-in-a-patient-with-multiple-sclerosis
#1
B Perlman, D Heller, B Cracchiolo
OBJECTIVE: Postmenopausal bleeding must always be evaluated to rule out endometrial carcinoma, although there are many benign etiologies. There have been rare reports of premenopausal bleeding with interferon beta-1b, used to treat multiple sclerosis, but no prior reports in postmenopausal women. METHODS: Literature searches were performed using PubMed and Medline for articles with content related to premenopausal and postmenopausal bleeding while taking interferon beta-1b...
October 17, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27645345/women-s-experiences-of-menopause-in-an-online-ms-cohort-a-case-series
#2
R Bove, T Vaughan, T Chitnis, P Wicks, P L De Jager
BACKGROUND: Many women with multiple sclerosis (MS) are postmenopausal. Previously reported findings from an online MS cohort suggested that earlier, surgical menopause may be associated with higher patient-reported MS severity scores. OBJECTIVE: To explore experiences of menopause in a series of MS women responding to a reproductive survey from an online research platform, PatientsLikeMe (PLM). METHODS: The free-text responses from a detailed reproductive history survey deployed to PLM members were analyzed using grounded theory approach...
September 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27605175/hormone-therapy-use-and-physical-quality-of-life-in-postmenopausal-women-with-multiple-sclerosis
#3
Riley Bove, Charles C White, Kathryn C Fitzgerald, Tanuja Chitnis, Lori Chibnik, Alberto Ascherio, Kassandra L Munger
OBJECTIVE: To determine the association between hormone therapy (HT) and physical quality of life (QOL) in postmenopausal women with multiple sclerosis (MS). METHODS: We included female participants from the prospective Nurses' Health Study, with a diagnosis of definite or probable MS, who had completed a physical functioning assessment (PF10; subscale of the 36-Item Short-Form Health Survey QOL survey) at a time point between 3 and 10 years after their final menstrual period (early postmenopause)...
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27605172/hormone-replacement-in-menopausal-women-with-multiple-sclerosis-looking-back-thinking-forward
#4
Rhonda Voskuhl, Francesco Patti
No abstract text is available yet for this article.
October 4, 2016: Neurology
https://www.readbyqxmd.com/read/27562581/structural-sex-differences-at-disease-onset-in-multiple-sclerosis-patients
#5
Juan Ignacio Rojas, Francisco Sánchez, Liliana Patrucco, Jimena Miguez, Jorge Funes, Edgardo Cristiano
BACKGROUND: Male sex is associated with worsening disability and a more rapid progression of multiple sclerosis (MS). This study analysed structural sex differences in magnetic resonance images of the brain, comparing women whose disease started before and after the menopause with a control group of men. METHODS: This was a case control study in which female patients whose MS started before (Group 1) and after (Group 2) the menopause were included. The control group was matched by age, disease duration, Expanded Disability Status Scale and disease-modifying treatment...
October 2016: Neuroradiology Journal
https://www.readbyqxmd.com/read/27116722/women-s-issues-in-multiple-sclerosis
#6
Riley Bove
Multiple sclerosis (MS) typically affects 3 times more women than men during the reproductive years. The author describes what is known about the effects of various reproductive exposures on MS course, including menarche, childbearing, and menopause. Then, the management of childbearing is reviewed. Topics include preconception counseling, prenatal care, discontinuation of MS therapies, and management of postpartum relapses. Overall, most women with MS can be encouraged to become pregnant and breastfeed their children, should they choose to do so...
April 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/26447063/exploration-of-changes-in-disability-after-menopause-in-a-longitudinal-multiple-sclerosis-cohort
#7
Riley Bove, Brian C Healy, Alexander Musallam, Bonnie I Glanz, Philip L De Jager, Tanuja Chitnis
BACKGROUND: Onset of multiple sclerosis (MS) is typically in early adulthood. The impact, if any, of menopause on the MS course is unknown. Our objective was to determine whether menopause is associated with changes in MS severity in a longitudinal clinical cohort. METHODS: Responses from an ongoing reproductive questionnaire deployed in all active female CLIMB observational study participants with a diagnosis of clinically isolated syndrome (CIS) or MS were analyzed when the response rate was 60%...
June 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/26195044/the-effect-of-menarche-age-parity-and-lactation-on-bone-mineral-density-in-premenopausal-ambulatory-multiple-sclerosis-patients
#8
Chrissa Sioka, Andreas Fotopoulos, Stilianos Papakonstantinou, Athanasia Georgiou, Sygliti-Henrietta Pelidou, Athanasios P Kyritsis, John A Kalef-Ezra
Although pregnancy and breast-feeding do not have any deleterious effect on disease activity in female multiple sclerosis (MS) patients, their role on bone mineral density (BMD) and osteoporosis risk is unknown. We investigated the role of age at menarche, parity and lactation on BMD expressed as percentage of the mean BMD (%BMD) in 46 pre-menopausal ambulatory female MS patients using dual-energy X-ray absorptiometry (DXA) scans in lumbar spine (LS) and hip. MS female patients with age at menarche ≥13 years old had reduced %BMD compared to those with menarche age <13 years (95...
July 2015: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/25787049/patients-report-worse-ms-symptoms-after-menopause-findings-from-an-online-cohort
#9
R Bove, B C Healy, E Secor, T Vaughan, B Katic, T Chitnis, P Wicks, P L De Jager
BACKGROUND: Many women with multiple sclerosis (MS) are postmenopausal, yet the impact of menopause on MS symptoms is unknown. OBJECTIVE: To investigate patient-reported impact of menopause in a large online research platform, PatientsLikeMe (PLM). METHODS: A detailed reproductive history survey was deployed to PLM members, and responses were linked to PLM׳s prospectively collected patient-reported severity score (MS Rating Scale, MSRS). The MSRS has previously shown good correlation with physician-derived EDSS scores...
January 2015: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/25544310/multiple-sclerosis-at-menopause-potential-neuroprotective-effects-of-estrogen
#10
REVIEW
Mindy S Christianson, Virginia A Mensah, Wen Shen
Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative condition of the central nervous system that preferentially afflicts women more than men. Low estrogen states such as menopause and the postpartum period favor exacerbations of multiple sclerosis in women with the disease. Existing and emerging evidence suggests a role for estrogen in the alleviation of symptoms and reversal of pathology associated with MS. While clinical evidence is sparse regarding the benefit of estrogen therapy for women at risk for MS exacerbations, scientific data demonstrates that estrogen potentiates numerous neuroprotective effects on the central nervous system (CNS)...
February 2015: Maturitas
https://www.readbyqxmd.com/read/25072319/women-with-the-alzheimer-s-risk-marker-apoe4-lose-a%C3%AE-specific-cd4%C3%A2-%C2%BA-t-cells-10-20-years-before-men
#11
A N Begum, C Cunha, H Sidhu, T Alkam, J Scolnick, E R Rosario, D W Ethell
Adaptive immunity to self-antigens causes autoimmune disorders, such as multiple sclerosis, psoriasis and type 1 diabetes; paradoxically, T- and B-cell responses to amyloid-β (Aβ) reduce Alzheimer's disease (AD)-associated pathology and cognitive impairment in mouse models of the disease. The manipulation of adaptive immunity has been a promising therapeutic approach for the treatment of AD, although vaccine and anti-Aβ antibody approaches have proven difficult in patients, thus far. CD4(+) T cells have a central role in regulating adaptive immune responses to antigens, and Aβ-specific CD4(+) T cells have been shown to reduce AD pathology in mouse models...
2014: Translational Psychiatry
https://www.readbyqxmd.com/read/24860668/association-between-smoking-and-health-outcomes-in-postmenopausal-women-living-with-multiple-sclerosis
#12
Rachel Jawahar, Unsong Oh, Charles Eaton, Nicole Wright, Hilary Tindle, Kate L Lapane
Background. In multiple sclerosis (MS), symptom management and improved health-related quality of life (HrQOL) may be modified by smoking. Objective. To evaluate the extent to which smoking is associated with worsened health outcomes and HrQOL for postmenopausal women with MS. Methods. We identified 251 Women's Health Initiative Observational Study participants with a self-reported MS diagnosis. Using a linear model, we estimated changes from baseline to 3 years for activities of daily living, total metabolic equivalent tasks (MET) hours per week, mental and physical component scales (MCS, PCS) of the SF-36, and menopausal symptoms adjusting for years since menopause and other confounders...
2014: Multiple Sclerosis International
https://www.readbyqxmd.com/read/24503510/prediction-of-risk-of-fracture-in-the-tibia-due-to-altered-bone-mineral-density-distribution-resulting-from-disuse-a-finite-element-study
#13
Magnus K Gislason, Sylvie Coupaud, Keisuke Sasagawa, Yuji Tanabe, Mariel Purcell, David B Allan, K Elizabeth Tanner
The disuse-related bone loss that results from immobilisation following injury shares characteristics with osteoporosis in post-menopausal women and the aged, with decreases in bone mineral density leading to weakening of the bone and increased risk of fracture. The aim of this study was to use the finite element method to: (i) calculate the mechanical response of the tibia under mechanical load and (ii) estimate of the risk of fracture; comparing between two groups, an able-bodied group and spinal cord injury patients group suffering from varying degrees of bone loss...
February 2014: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/24137163/functions-of-nod-like-receptors-in-human-diseases
#14
REVIEW
Yifei Zhong, Anna Kinio, Maya Saleh
Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly conserved cytosolic pattern recognition receptors that perform critical functions in surveying the intracellular environment for the presence of infection, noxious substances, and metabolic perturbations. Sensing of these danger signals by NLRs leads to their oligomerization into large macromolecular scaffolds and the rapid deployment of effector signaling cascades to restore homeostasis. While some NLRs operate by recruiting and activating inflammatory caspases into inflammasomes, others trigger inflammation via alternative routes including the nuclear factor-κB, mitogen-activated protein kinase, and regulatory factor pathways...
2013: Frontiers in Immunology
https://www.readbyqxmd.com/read/24101131/menopause-in-multiple-sclerosis-therapeutic-considerations
#15
REVIEW
Riley Bove, Tanuja Chitnis, Maria Houtchens
While the onset of multiple sclerosis (MS) typically occurs during the childbearing years, many women living with MS are of perimenopausal age. There is frequent overlap between menopausal and MS-related symptoms and co-morbidities (e.g. sexual dysfunction, mood disorders and bladder function). Furthermore, some MS symptoms may be exacerbated by perimenopausal changes such as hot flashes or sleep disturbance. The MS neurologist may frequently be the first to become aware of these symptoms and to play a role in monitoring and managing them...
July 2014: Journal of Neurology
https://www.readbyqxmd.com/read/23822612/no-sex-specific-difference-in-disease-trajectory-in-multiple-sclerosis-patients-before-and-after-age-50
#16
Riley Bove, Alexander Musallam, Brian C Healy, Maria Houtchens, Bonnie I Glanz, Samia Khoury, Charles R Guttmann, Philip L De Jager, Tanuja Chitnis
BACKGROUND: The disease course in multiple sclerosis (MS) is influenced by many factors, including age, sex, and sex hormones. Little is known about sex-specific changes in disease course around age 50, which may represent a key biological transition period for reproductive aging. METHODS: Male and female subjects with no prior chemotherapy exposure were selected from a prospective MS cohort to form groups representing the years before (38-46 years, N=351) and after (54-62 years, N=200)age 50...
2013: BMC Neurology
https://www.readbyqxmd.com/read/23604287/age-related-pathology-and-biosenescent-markers-in-captive-rhesus-macaques
#17
H Uno
During the past 15 years, our aging colony of rhesus monkeys, consisting of animals from 20 to 37 years of age, had an annual average population of 88.2 live monkeys and, of this population, an annual average of 13.9 monkeys died spontaneously or were terminated due to severe illness. From 1980 to 1994, a total of 175 autopsies of rhesus macaques, from 20 to 37 years of age, were performed. By cumulative autopsy data, the incidence of age-related pathology in various organs was surveyed. Major geriatric diseases such as coronary sclerosis, emphysema, degenerative joint disorders, cancer, and cerebral amyloid plaque began to develop in 10 to 40% of macaques after 20 years and the incidence significantly increased after 26 years of age...
January 1997: Age (1978-1999)
https://www.readbyqxmd.com/read/23522436/autoimmune-diseases-and-reproductive-aging
#18
REVIEW
Riley Bove
As the population ages, more individuals with autoimmune diseases are experiencing reproductive senescence. Understanding the impact of menopause and age-related androgen decline on disease onset and course, as well as the potential for hormonal interventions, is critically important. In men, lupus erythematosis (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS) are associated with lower androgen levels. However, the impact of age-related declines in testosterone, as well as of testosterone replacement, on disease course remains underexplored...
November 2013: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/22733837/female-reproductive-issues-in-multiple-sclerosis
#19
REVIEW
Pamela A McCombe, Judith M Greer
Multiple sclerosis (MS) is more common in females than males and frequently affects women during their reproductive years. Thus, issues surrounding pregnancy and reproduction are of concern to women with MS. This review documents studies that shed light on reproductive issues in women with MS. The available literature was searched for papers relating to pregnancy and MS. Pregnancy is protective in MS in the short term, perhaps due to modulation of the immune system in pregnancy. It also possible that changes in the brain in pregnancy could protect against the effects of inflammation...
April 2013: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/22567504/gastric-cancer-in-the-setting-of-persistently-elevated-human-chorionic-gonadotropin-a-case-report
#20
Latoya R Walker, Brian Erler
A 35-year-old woman presented to the emergency room for the evaluation of failed surgical and medical management of a suspected ectopic pregnancy. When imaging studies were performed, she had lymphadenopathy and diffuse sclerosis of the osseous framework. Multiple biopsies were performed and revealed poorly differentiated metastatic carcinoma with signet ring features. Esophagogastroduodenoscopy confirmed the findings of a Stage IV gastric adenocarcinoma. Signs and symptoms of gastric carcinoma are vague. However, to our knowledge, an elevation in human chorionic gonadotropin (hCG) is not an associated finding...
2011: Case Reports in Obstetrics and Gynecology
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