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Smoking-related interstitial fibrosis

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https://www.readbyqxmd.com/read/29043847/smoking-related-interstitial-fibrosis-evidence-of-radiologic-regression-with-advancing-age-and-smoking-cessation
#1
Aurélie Fabre, Ann Treacy, Lisa P Lavelle, Maciek Narski, Nazia Faheem, David Healy, Jonathan D Dodd, Michael P Keane, James J Egan, Gilles Jebrak, Hervé Mal, Marcus W Butler
More data are needed regarding the radiology, co-morbidities and natural history of smoking-related interstitial fibrosis (SRIF), a common pathological finding, mainly described heretofore in association with lung cancer, where respiratory bronchiolitis (RB) usually co-exists. We prospectively acquired high resolution CT scan data (edge-enhancing lung reconstructions) to detect any radiologic interstitial lung abnormality (ILA) in individuals who ultimately underwent surgical lobectomy for lung cancer (n = 20), for radiologic/pathologic correlation...
October 18, 2017: COPD
https://www.readbyqxmd.com/read/28689212/coal-mine-dust-desquamative-chronic-interstitial-pneumonia-a-precursor-of-dust-related-diffuse-fibrosis-and-of-emphysema
#2
Tomislav M Jelic, Oscar C Estalilla, Phyllis R Sawyer-Kaplan, Milton J Plata, Jeremy T Powers, Mary Emmett, John T Kuenstner
BACKGROUND: Diseases associated with coal mine dust continue to affect coal miners. Elucidation of initial pathological changes as a precursor of coal dust-related diffuse fibrosis and emphysema, may have a role in treatment and prevention. OBJECTIVE: To identify the precursor of dust-related diffuse fibrosis and emphysema. METHODS: Birefringent silica/silicate particles were counted by standard microscope under polarized light in the alveolar macrophages and fibrous tissue in 25 consecutive autopsy cases of complicated coal worker's pneumoconiosis and in 21 patients with tobacco-related respiratory bronchiolitis...
July 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28679612/functional-and-prognostic-effects-when-emphysema-complicates-idiopathic-pulmonary-fibrosis
#3
Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Maria Kokosi, Toby M Maher, Arjun Nair, Ronald Karwoski, Elisabetta Renzoni, Simon L F Walsh, David M Hansell, Athol U Wells
This study aimed to investigate whether the combination of fibrosis and emphysema has a greater effect than the sum of its parts on functional indices and outcome in idiopathic pulmonary fibrosis (IPF), using visual and computer-based (CALIPER) computed tomography (CT) analysis.Consecutive patients (n=272) with a multidisciplinary IPF diagnosis had the extent of interstitial lung disease (ILD) scored visually and by CALIPER. Visually scored emphysema was subcategorised as isolated or mixed with fibrotic lung...
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28641716/the-effects-of-pleural-plaques-on-longitudinal-lung-function-in-vermiculite-miners-of-libby-montana
#4
Kathleen A Clark, J Jay Flynn, Wilfried J J Karmaus, Lawrence C Mohr
BACKGROUND: This study was conducted to assess associations of pleural plaques (PP) and longitudinal lung function in vermiculite miners of Libby, Montana who are occupationally exposed to asbestos. High-resolution computed tomography (HRCT) was used to identify asbestos-related findings in former Libby vermiculite miners. We investigated annual lung function decline in miners with PP only and compared them to miners with normal HRCT findings. MATERIALS AND METHODS: HRCTs from 128 miners were categorized into the following 4 diagnostic groups: (1) normal computed tomography scan (n = 9); (2) PP only (n = 72); (3) PP and interstitial fibrosis (n = 26) and (4) additional HRCT abnormalities (n = 21) such as rounded atelectasis, diffuse pleural thickening, pleural effusions or pulmonary nodules or tumor >1cm in diameter...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28370144/lung-function-not-affected-by-asbestos-exposure-in-workers-with-normal-computed-tomography-scan
#5
Christian Schikowsky, Michael K Felten, Christian Eisenhawer, Marco Das, Thomas Kraus
BACKGROUND: It has been suggested that asbestos exposure affects lung function, even in the absence of asbestos-related pulmonary interstitial or pleural changes or emphysema. METHODS: We analyzed associations between well-known asbestos-related risk factors, such as individual cumulative asbestos exposure, and key lung function parameters in formerly asbestos-exposed power industry workers (N = 207) with normal CT scans. For this, we excluded participants with emphysema, fibrosis, pleural changes, or any combination of these...
May 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28239542/a-case-of-mixed-dust-pneumoconiosis-with-desquamative-interstitial-pneumonia-like-reaction-in-an-aluminum-welder
#6
Yuki Iijima, Masashi Bando, Hideaki Yamasawa, Hiroshi Moriyama, Tamiko Takemura, Toshiro Niki, Yukihiko Sugiyama
A 60-year-old man presented with an 18-month history of gradually worsening cough and a 12-month history of dyspnea on exertion. High-resolution computed tomography showed bilateral uniform ground grass opacity in the lower lung fields, partially resolved by smoking cessation. A tentative diagnosis of desquamative interstitial pneumonia (DIP) was made. Video-assisted thoracic surgery was performed and pathological analysis showed peribronchiolar fibrosis with intra-alveolar macrophage infiltration. Elemental analysis detected aluminum and iron in the upper lobe and only iron in the lower lobe...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27986796/association-of-cardiovascular-risk-factors-and-myocardial-fibrosis-with-early-cardiac-dysfunction-in-type-1-diabetes-the-diabetes-control-and-complications-trial-epidemiology-of-diabetes-interventions-and-complications-study
#7
Anderson C Armstrong, Bharath Ambale-Venkatesh, Evrim Turkbey, Sirisha Donekal, Elzbieta Chamera, Jye-Yu Backlund, Patricia Cleary, John Lachin, David A Bluemke, João A C Lima
OBJECTIVE: We investigated the association of cardiovascular risk factors and myocardial fibrosis with early cardiac dysfunction in type 1 diabetes. RESEARCH DESIGN AND METHODS: Participants with type 1 diabetes aged 13-39 years without a known history of cardiovascular disease (CVD) (n = 1,441) were recruited into the Diabetes Control and Complications Trial (1983-1993) and subsequently followed in the Epidemiology of Diabetes Interventions and Complications study (1994 to present)...
March 2017: Diabetes Care
https://www.readbyqxmd.com/read/27977621/lung-cancer-development-in-patients-with-connective-tissue-disease-related-interstitial-lung-disease-a-retrospective-observational-study
#8
Yasunori Enomoto, Naoki Inui, Katsuhiro Yoshimura, Koji Nishimoto, Kazutaka Mori, Masato Kono, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Toshihide Iwashita, Takafumi Suda
Previous studies have reported that patients with idiopathic pulmonary fibrosis occasionally develop lung cancer (LC). However, in connective tissue disease (CTD)-related interstitial lung disease (ILD), there are few data regarding the LC development. The aim of the present study was to evaluate the clinical significance of LC development in patients with CTD-ILD. A retrospective review of our database of 562 patients with ILD between 2000 and 2014 identified 127 patients diagnosed with CTD-ILD. The overall and cumulative incidences of LC were calculated...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27940964/chronic-exposure-to-water-pipe-smoke-induces-cardiovascular-dysfunction-in-mice
#9
Abderrahim Nemmar, Suhail Al-Salam, Priya Yuvaraju, Sumaya Beegam, Javed Yasin, Badreldin H Ali
Water-pipe tobacco smoking is becoming prevalent in all over the world including Western countries. There are limited data on the cardiovascular effects of water-pipe smoke (WPS), in particular following chronic exposure. Here, we assessed the chronic cardiovascular effects of nose-only WPS exposure in C57BL/6 mice. The duration of the session was 30 minutes/day, 5 days/week for 6 consecutive months. Control mice were exposed to air. WPS significantly increased systolic blood pressure. The relative heart weight and plasma concentrations of troponin-I and B-type natriuretic peptide were increased in mice exposed to WPS...
February 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27719975/clinical-radiologic-pathologic-correlation-of-smoking-related-diffuse-parenchymal-lung-disease
#10
REVIEW
Seth Kligerman, Teri J Franks, Jeffrey R Galvin
The direct toxicity of cigarette smoke and the body's subsequent response to this lung injury leads to a wide array of pathologic manifestations and disease states that lead to both reversible and irreversible injury to the large airways, small airways, alveolar walls, and alveolar spaces. These include emphysema, bronchitis, bronchiolitis, acute eosinophilic pneumonia, pulmonary Langerhans cell histiocytosis, respiratory bronchiolitis, desquamative interstitial pneumonia, and pulmonary fibrosis. Although these various forms of injury have different pathologic and imaging manifestations, they are all part of the spectrum of smoking-related diffuse parenchymal lung disease...
November 2016: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/27611866/differentiating-smoking-related-interstitial-fibrosis-srif-from-usual-interstitial-pneumonia-uip-with-emphysema-using-ct-features-based-on-pathologically-proven-cases
#11
Kum Ju Chae, Gong Yong Jin, Hyun Nyeong Jung, Keun Sang Kwon, Hyemi Choi, Yong Chul Lee, Myoung Ja Chung, Ho Sung Park
OBJECTIVE: To differentiate smoking-related interstitial fibrosis (SRIF) from usual interstitial pneumonia (UIP) with emphysema on CT in combined pulmonary fibrosis and emphysema (CPFE) patients. MATERIALS AND METHODS: This study was approved by the institutional review board and informed consent was waived. We included 65 patients who underwent lung biopsy under the suspicion of UIP pattern on HRCT, and after radiologic-pathologic correlation, they were divided into three groups: UIP without emphysema (n = 30), UIP with emphysema (n = 26), and SRIF (n = 9)...
2016: PloS One
https://www.readbyqxmd.com/read/27485309/abundant-immunoglobulin-ig-g4-positive-plasma-cells-in-interstitial-pneumonia-without-extrathoracic-lesions-of-igg4-related-disease-is-this-finding-specific-to-igg4-related-lung-disease
#12
Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Koji Okudela, Tae Iwasawa, Fumikazu Sakai, Kenji Notohara, Kenichi Ohashi, Tamiko Takemura, Takashi Ogura
AIMS: There have been few reports on immunoglobulin-G4 (IgG4)-related interstitial pneumonia (IP), and its clinical features remain unclear. The objective of this study was to assess whether IP with marked IgG4-positive plasma cell infiltration without extrathoracic lesions of IgG4-related disease (RD) should be diagnosed as a subtype of IgG4-RD or a separate entity. METHODS AND RESULTS: All consecutive patients with surgical lung biopsy-proven idiopathic IP with an IgG4/IgG-positive cell ratio of >40% and >50 IgG4(+) plasma cells in a high-power field without extrathoracic lesions of IgG4-RD were reviewed retrospectively...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27445472/smoking-related-interstitial-fibrosis-combined-with-pulmonary-emphysema-computed-tomography-pathologic-correlative-study-using-lobectomy-specimens
#13
COMPARATIVE STUDY
Hideji Otani, Tomonori Tanaka, Kiyoshi Murata, Junya Fukuoka, Norihisa Nitta, Yukihiro Nagatani, Akinaga Sonoda, Masashi Takahashi
PURPOSE: To evaluate the incidence and pathologic correlation of thin-section computed tomography (TSCT) findings in smoking-related interstitial fibrosis (SRIF) with pulmonary emphysema. PATIENTS AND METHODS: Our study included 172 consecutive patients who underwent TSCT and subsequent lobectomy. TSCT findings including clustered cysts with visible walls (CCVW) and ground-glass attenuation with/without reticulation (GGAR) were evaluated and compared in nonsmokers and smokers and among lung locations...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27307724/are-interstitial-lung-abnormalities-associated-with-copd-a-nested-case-control-study
#14
MULTICENTER STUDY
Francesca Bozzetti, Ilaria Paladini, Enrico Rabaiotti, Alessandro Franceschini, Veronica Alfieri, Alfredo Chetta, Ernesto Crisafulli, Mario Silva, Ugo Pastorino, Nicola Sverzellati
PURPOSE: In this study, we tested the association between COPD and interstitial lung abnormality (ILA), notably in relation to the presence of computed tomography (CT) signs of lung fibrosis. PATIENTS AND METHODS: COPD cases were selected from participants undergoing lung cancer screening (Multicentric Italian Lung Detection trial) for airflow obstruction (n=311/2,303, 13.5%) and 146 consecutive patients with clinical COPD. In all, 457 COPD cases were selected and classified according to the stages of Global Initiative for Chronic Obstructive Lung Disease...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/26914911/risk-factors-associated-with-quantitative-evidence-of-lung-emphysema-and-fibrosis-in-an-hiv-infected-cohort
#15
MULTICENTER STUDY
Joseph K Leader, Kristina Crothers, Laurence Huang, Mark A King, Alison Morris, Bruce W Thompson, Sonia C Flores, Michael B Drummond, William N Rom, Philip T Diaz
INTRODUCTION: The disease spectrum for HIV-infected individuals has shifted toward comorbid non-AIDS conditions including chronic lung disease, but quantitative image analysis of lung disease has not been performed. OBJECTIVES: To quantify the prevalence of structural changes of the lung indicating emphysema or fibrosis on radiographic examination. METHODS: A cross-sectional analysis of 510 HIV-infected participants in the multicenter Lung-HIV study was performed...
April 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/26479130/spectrum-of-smoking-related-lung-diseases-imaging-review-and-update
#16
REVIEW
Rachna Madan, Shanna Matalon, Marina Vivero
There is increased awareness of smoking-related lung diseases other than lung cancer and chronic obstructive pulmonary disease. Concurrently, there is general acceptance that there is difficulty in establishing a specific diagnosis of smoking-related interstitial lung disease (ILD), as many patients may not undergo biopsy to facilitate a specific histopathologic diagnosis. Cases that do proceed to biopsy may demonstrate multiple abnormalities, and histologic overlap between different disease processes may confound the picture...
March 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/26452110/american-thoracic-society-european-respiratory-society-classification-of-the-idiopathic-interstitial-pneumonias-advances-in-knowledge-since-2002
#17
Nicola Sverzellati, David A Lynch, David M Hansell, Takeshi Johkoh, Talmadge E King, William D Travis
In the updated American Thoracic Society-European Respiratory Society classification of the idiopathic interstitial pneumonias (IIPs), the major entities have been preserved and grouped into (a) "chronic fibrosing IIPs" (idiopathic pulmonary fibrosis and idiopathic nonspecific interstitial pneumonia), (b) "smoking-related IIPs" (respiratory bronchiolitis-associated interstitial lung disease and desquamative interstitial pneumonia), (c) "acute or subacute IIPs" (cryptogenic organizing pneumonia and acute interstitial pneumonia), and (d) "rare IIPs" (lymphoid interstitial pneumonia and idiopathic pleuroparenchymal fibroelastosis)...
November 2015: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/26138798/smoking-related-idiopathic-interstitial-pneumonia-a-review
#18
REVIEW
George A Margaritopoulos, Sergio Harari, Antonella Caminati, Katerina M Antoniou
For many years, cigarette smoking has been considered as the leading cause of chronic obstructive pulmonary disease and lung cancer. Recently, however, it has also been associated with the development of diffuse interstitial lung diseases. In the latest classification of the major idiopathic interstitial pneumonias (IIP), the term smoking-related IIP has been introduced, including two entities, namely desquamative interstitial pneumonia (DIP) and respiratory bronchiolitis-interstitial lung disease (RB-ILD)...
January 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/26106641/exhaled-breath-condensate-technical-and-diagnostic-aspects
#19
REVIEW
Efstathia M Konstantinidi, Andreas S Lappas, Anna S Tzortzi, Panagiotis K Behrakis
PURPOSE: The aim of this study was to evaluate the 30-year progress of research on exhaled breath condensate in a disease-based approach. METHODS: We searched PubMed/Medline, ScienceDirect, and Google Scholar using the following keywords: exhaled breath condensate (EBC), biomarkers, pH, asthma, gastroesophageal reflux (GERD), smoking, COPD, lung cancer, NSCLC, mechanical ventilation, cystic fibrosis, pulmonary arterial hypertension (PAH), idiopathic pulmonary fibrosis, interstitial lung diseases, obstructive sleep apnea (OSA), and drugs...
2015: TheScientificWorldJournal
https://www.readbyqxmd.com/read/26090479/anti-cyclic-citrullinated-peptide-antibodies-and-severity-of-interstitial-lung-disease-in-women-with-rheumatoid-arthritis
#20
Alberto Daniel Rocha-Muñoz, Manuel Ponce-Guarneros, Jorge Ivan Gamez-Nava, Eva Maria Olivas-Flores, Mayra Mejía, Pablo Juárez-Contreras, Erika Aurora Martínez-García, Esther Guadalupe Corona-Sánchez, Tania Marlen Rodríguez-Hernández, Mónica Vázquez-del Mercado, Mario Salazar-Páramo, Arnulfo Hernan Nava-Zavala, Ernesto German Cardona-Muñoz, Alfredo Celis, Laura González-Lopez
OBJECTIVE: To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). METHODS: In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified...
2015: Journal of Immunology Research
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