keyword
https://read.qxmd.com/read/38500898/a-comparison-of-the-effectiveness-of-nintedanib-and-pirfenidone-in-treating-idiopathic-pulmonary-fibrosis-a-systematic-review
#1
REVIEW
Ruzhual K Man, Amaresh Gogikar, Ankita Nanda, Lakshmi Sai Niharika Janga, Hembashima G Sambe, Mohamed Yasir, Shivana Ramphall
Idiopathic pulmonary fibrosis (IPF), which shares a radiographic pattern with the usual interstitial pneumonia (UIP), is a specific form of chronic and progressive interstitial lung disorder resulting in persistent fibrosis and impaired lung function. Most of the patients suffer from dyspnea which adversely affects health-related quality of life (HRQOL). The underlying etiology of the disease is not yet understood, but research done on the subject reveals that aberrant repair mechanisms and dysregulated immune responses may be the cause...
February 2024: Curēus
https://read.qxmd.com/read/38485275/-18-f-fdg-pet-ct-signal-correlates-with-neoangiogenesis-markers-in-patients-with-fibrotic-interstitial-lung-disease-who-underwent-lung-biopsy-implication-for-the-use-of-pet-ct-in-diffuse-lung-diseases
#2
JOURNAL ARTICLE
Joanna C Porter, Balaji Ganeshan, Thida Win, Francesco Fraioli, Saif Khan, Manuel Rodriguez-Justo, Raymond Endozo, Robert I Shortman, Luke R Hoy, Toby M Maher, Ashley M Groves
The use of [18 F]FDG PET/CT as a biomarker in diffuse lung diseases is increasingly recognized. We investigated the correlation between [18 F]FDG uptake with histologic markers on lung biopsy of patients with fibrotic interstitial lung disease (fILD). Methods: We recruited 18 patients with fILD awaiting lung biopsy for [18 F]FDG PET/CT. We derived a target-to-background ratio (TBR) of maximum pulmonary uptake of [18 F]FDG (SUVmax ) divided by the lung background (SUVmin ). Consecutive paraffin-embedded lung biopsy sections were immunostained for alveolar and interstitial macrophages (CD68), microvessel density (MVD) (CD31 and CD105/endoglin), and glucose transporter 1...
March 14, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38484788/overview-of-rheumatoid-arthritis-associated-interstitial-lung-disease-and-its-treatment
#3
JOURNAL ARTICLE
Janelle Vu Pugashetti, Joyce S Lee
Interstitial lung disease (ILD) is a common pulmonary complication of rheumatoid arthritis (RA), causing significant morbidity and mortality. Optimal treatment for RA-ILD is not yet well defined. Reliable prognostic indicators are largely byproducts of prior ILD progression, including low or decreasing forced vital capacity and extensive or worsening fibrosis on imaging. In the absence of validated tools to predict treatment response, decisions about whether to initiate or augment treatment are instead based on clinical judgment...
March 14, 2024: Seminars in Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38459356/clinical-characteristics-of-patients-with-connective-tissue-disease-related-interstitial-lung-disease-a-retrospective-analysis
#4
JOURNAL ARTICLE
Seda Colak, Emre Tekgoz, Ezgi Cimen Gunes, Nesrin Ocal, Deniz Dogan, Canturk Tasci, Muhammet Cinar, Sedat Yilmaz
INTRODUCTION: Interstitial lung disease is one of the most critical manifestations of connective tissue diseases that may cause morbidity and mortality. This study aimed to evaluate the clinical and demographic characteristics and treatment of the patients with connective tissue disease-related interstitial lung disease. METHOD: This retrospective observational study included patients from the Gulhane Rheumatology Interstitial Lung Disease cohort between October 2016 and June 2023...
March 9, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38446195/the-relationship-between-anti-ssa-52-and-interstitial-lung-disease
#5
JOURNAL ARTICLE
Hollie Saunders, Hassan Baig, Yan Li, Launia White, David Hodge, Elizabeth Lesser, Justin T Stowell, Carlos A Rojas, Isabel Mira-Avendano
OBJECTIVE: The aims of this study were to assess whether a relationship between anti-SSA-52 and interstitial lung disease (ILD) can be further defined, and to enhance screening, detection, and potentially guide treatment. METHODS: A historical cohort study of 201 patients was conducted at a single tertiary care center between January 1, 2016 and December 31, 2020. All included patients were anti-SSA-52 antibody positive. Chart review was performed for laboratory values, symptoms, pulmonary function tests, treatment, and imaging...
March 5, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38434331/radiological-usual-interstitial-pneumonia-pattern-is-associated-with-two-year-mortality-in-patients-with-idiopathic-pulmonary-fibrosis
#6
JOURNAL ARTICLE
Ignacio Gayá García-Manso, Juan Arenas Jiménez, Luis Hernández Blasco, Elena García Garrigós, Ester Nofuentes Pérez, Marina Sirera Matilla, Sandra Ruiz Alcaraz, Raquel García Sevila
INTRODUCTION: The new diagnostic guidelines for idiopathic pulmonary fibrosis (IPF) did not rule out the possibility of combining the radiological patterns of usual interstitial pneumonia (UIP) and probable UIP, given the similar management and diagnostic capacity. However, the prognostic implications of these patterns have not been fully elucidated, with different studies showing heterogeneous results. We applied the new criteria to a retrospective series of patients with IPF, assessing survival based on radiological patterns, findings, and their extension...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38433068/-the-concept-of-interstitial-pneumonia-with-autoimmune-features-ipaf
#7
REVIEW
J Bermudez, P Habert, B Coiffard
Interstitial lung diseases (ILD) are a heterogeneous group of respiratory diseases often related to connective tissue diseases. Some patients will develop an ILD with autoimmune features without reaching the recommended criteria for autoimmune diseases. Their management is difficult because they have both features for idiopathic and connective tissue disease. To better identify these patients, the concept of interstitial pneumonia with autoimmune features (IPAF) has been created. The diagnosis relies on ILD without identified cause and the presence of at least one defined criterion among 2 of the 3 following domains: clinic, serologic, and morphologic...
March 2, 2024: La Revue de Médecine Interne
https://read.qxmd.com/read/38415479/evaluation-of-interstitial-lung-diseases-with-deep-learning-method-of-two-major-computed-tomography-patterns
#8
JOURNAL ARTICLE
Hüseyin Alper Kiziloğlu, Emrah Çevik, Kenan Zengin
BACKGROUND: Interstitial lung diseases (ILD) encompass various disorders characterized by inflammation and/or fibrosis in the lung interstitium. These conditions produce distinct patterns in High-Resolution Computed Tomography (HRCT). OBJECTIVE: We employ a deep learning method to diagnose the most commonly encountered patterns in ILD differentially. MATERIALS AND METHODS: Patients were categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), and normal lung parenchyma groups...
February 26, 2024: Current medical imaging
https://read.qxmd.com/read/38410568/surgical-lung-biopsy-for-suspected-interstitial-lung-disease-with-video-assisted-thoracoscopic-surgery-is-safe-providing-exact-histological-and-disease-specific-diagnosis-for-tailoring-treatment
#9
JOURNAL ARTICLE
Leifur Thrainsson, Arnljotur Bjorn Halldorsson, Arnar Bragi Ingason, Helgi J Isaksson, Gunnar Gudmundsson, Tomas Gudbjartsson
BACKGROUND: Surgical lung biopsy (SLB) is required for diagnosis in patients with suspected interstitial lung disease (ILD) if other less invasive diagnostic methods are non-conclusive. We evaluated the outcome of SLB by using centralized databases in a whole-nation patient-cohort. METHODS: A population-based retrospective study on 68 consecutive patients (mean age 58 years, 58.8% males) that underwent SLB in Iceland between the years 2008 and 2020. Patient information was obtained from patient charts and peri- and postoperative complications were registered together with 30- and 90-day mortality...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38384315/clustered-cystic-changes-in-long-term-follow-up-thin-section-computed-tomographic-findings-in-fibrotic-nonspecific-interstitial-pneumonia
#10
JOURNAL ARTICLE
Masanori Akira, Narufumi Suganuma
OBJECTIVES: The purpose of this study was to retrospectively assess cystic changes in findings on follow-up CT scans of patients with fibrotic nonspecific interstitial pneumonia (NSIP). METHODS: The initial and last high-resolution CT scans of 58 patients with pathologically proven fibrotic NSIP were evaluated retrospectively. The median follow-up periods were 48 months (range, 12-183 months). The pattern, extent, and distribution of abnormal CT findings were compared with findings in the same region on previous and subsequent CT scans with a focus on cystic lesions...
2024: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/38363440/interstitial-lung-disease-and-associated-factors-in-patients-with-sj%C3%A3-gren-s-syndrome
#11
JOURNAL ARTICLE
Gökhan Sargın, Huseyin Baygin, Songul Cildag, Taskin Senturk
BACKGROUND: Interstitial lung disease (ILD) is a common pulmonary manifestation of Sjögren's syndrome (SjS) and associated with an increased risk of death. Early detection and treatment of ILDs and knowing the risk factors are very important for prognosis in rheumatic diseases. AIMS: This study was performed to determine ILD and associated factors in patients with SjS. METHODS: Four hundred three SjS patients were evaluated in this cross-sectional cohort study...
February 16, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38358328/thin-section-ct-in-the-categorization-and-management-of-pulmonary-fibrosis-including-recently-defined-progressive-pulmonary-fibrosis
#12
REVIEW
Rosita M Shah, Ana M Kolansky, Seth Kligerman
While idiopathic pulmonary fibrosis (IPF) is the most common type of fibrotic lung disease, there are numerous other causes of pulmonary fibrosis that are often characterized by lung injury and inflammation. Although often gradually progressive and responsive to immune modulation, some cases may progress rapidly with reduced survival rates (similar to IPF) and with imaging features that overlap with IPF, including usual interstitial pneumonia (UIP)-pattern disease characterized by peripheral and basilar predominant reticulation, honeycombing, and traction bronchiectasis or bronchiolectasis...
February 2024: Radiology. Cardiothoracic imaging
https://read.qxmd.com/read/38357055/a-rare-case-of-spontaneous-pneumothorax-leading-to-cerebral-air-embolism
#13
Zakaria Alagha, Amro Al-Astal
Cerebral arterial air embolism (CAE), a rare subtype of air embolism, carries a 21% mortality rate. We present a unique case involving a 69-year-old female with a history of usual interstitial pneumonia (UIP) who suffered a transient ischemic attack (TIA) due to CAE. Unlike typical cases, CAE in this instance resulted from spontaneous pneumothorax, not the more common iatrogenic causes. Adding complexity, an unexpected discovery emerged during evaluation: a patent foramen ovale, contributing to paradoxical embolism...
January 2024: Curēus
https://read.qxmd.com/read/38345107/similarities-and-differences-of-interstitial-lung-disease-associated-with-pathogenic-variants-in-sftpc-and-abca3-in-adults
#14
JOURNAL ARTICLE
Rémi Diesler, Marie Legendre, Salim Si-Mohamed, Pierre-Yves Brillet, Lidwine Wemeau, Effrosyni D Manali, Frédéric Gagnadoux, Sandrine Hirschi, Gwenaël Lorillon, Martine Reynaud-Gaubert, Vanessa Bironneau, Elodie Blanchard, Arnaud Bourdin, Stéphane Dominique, Aurélien Justet, Julie Macey, Sylvain Marchand-Adam, Hélène Morisse-Pradier, Hilario Nunes, Spyros A Papiris, Julie Traclet, Ibrahim Traore, Bruno Crestani, Serge Amselem, Nadia Nathan, Raphaël Borie, Vincent Cottin
BACKGROUND AND OBJECTIVE: Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults. METHODS: We conducted a multicentre retrospective study of all consecutive adult patients diagnosed with ILD associated with variants in SFTPC or ABCA3 in the French rare pulmonary diseases network, OrphaLung. Variants and chest computed tomography (CT) features were centrally reviewed. RESULTS: We included 36 patients (median age: 34 years, 20 males), 22 in the SFTPC group and 14 in the ABCA3 group...
February 12, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38343230/analysis-of-validation-performance-of-a-machine-learning-classifier-in-interstitial-lung-disease-cases-without-definite-or-probable-usual-interstitial-pneumonia-pattern-on-ct-using-clinical-and-pathology-supported-diagnostic-labels
#15
JOURNAL ARTICLE
Marcello Chang, Joshua J Reicher, Angad Kalra, Michael Muelly, Yousef Ahmad
We previously validated Fibresolve, a machine learning classifier system that non-invasively predicts idiopathic pulmonary fibrosis (IPF) diagnosis. The system incorporates an automated deep learning algorithm that analyzes chest computed tomography (CT) imaging to assess for features associated with idiopathic pulmonary fibrosis. Here, we assess performance in assessment of patterns beyond those that are characteristic features of usual interstitial pneumonia (UIP) pattern. The machine learning classifier was previously developed and validated using standard training, validation, and test sets, with clinical plus pathologically determined ground truth...
January 11, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38339314/safety-and-efficacy-of-single-fraction-carbon-ion-radiotherapy-for-early-stage-lung-cancer-with-interstitial-pneumonia
#16
JOURNAL ARTICLE
Shuri Aoki, Hitoshi Ishikawa, Mio Nakajima, Naoyoshi Yamamoto, Shinichiro Mori, Tokuhiko Omatsu, Yuji Tada, Teruaki Mizobuchi, Satoshi Ikeda, Ichiro Yoshino, Shigeru Yamada
Patients with lung cancer complicated by interstitial pneumonia (IP) often lose treatment options early owing to acute exacerbation of IP concerns. Carbon-ion radiotherapy (CIRT) can provide superior tumor control and low toxicity at high dose concentrations. We conducted a retrospective analysis of the efficacy and tolerability of a single-fraction CIRT using 50 Gy for IP-complicated lung cancer. The study included 50 consecutive patients treated between April 2013 and September 2022, whose clinical stage of lung cancer (UICC 7th edition) was 1A:1B:2A:2B = 32:13:4:1...
January 29, 2024: Cancers
https://read.qxmd.com/read/38336872/lung-imaging-patterns-in-connective-tissue-disease-associated-interstitial-lung-disease-impact-prognosis-and-immunosuppression-response
#17
JOURNAL ARTICLE
Boyang Zheng, Daniel-Costin Marinescu, Cameron J Hague, Nestor L Muller, Darra Murphy, Andrew Churg, Joanne L Wright, Amna Al-Arnawoot, Ana-Maria Bilawich, Patrick Bourgouin, Gerard Cox, Celine Durand, Tracy Elliot, Jennifer Ellis, Jolene H Fisher, Derek Fladeland, Amanda Grant-Orser, Gillian C Goobie, Zachary Guenther, Ehsan Haider, Nathan Hambly, James Huynh, Kerri A Johannson, Geoffrey Karjala, Nasreen Khalil, Martin Kolb, Jonathon Leipsic, Stacey Lok, Sarah MacIsaac, Micheal McInnis, Helene Manganas, Veronica Marcoux, John Mayo, Julie Morisset, Ciaran Scallan, Tony Sedlic, Shane Shapera, Kelly Sun, Victoria Tan, Alyson W Wong, Christopher J Ryerson
OBJECTIVES: Interstitial lung disease (ILD) in connective tissue diseases (CTD) have highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality and immunosuppression response. METHODS: Patients with CTD-ILD had high-resolution chest computed tomography (HRCT) reviewed by expert radiologists blinded to clinical data for overall imaging pattern (usual interstitial pneumonia [UIP]; non-specific interstitial pneumonia [NSIP]; organizing pneumonia [OP]; fibrotic hypersensitivity pneumonitis [fHP]; and other)...
February 9, 2024: Rheumatology
https://read.qxmd.com/read/38326675/clinical-and-immunological-characteristics-and-prognosis-of-patients-with-autoantibody-negative-dermatomyositis-a-case-control-study
#18
JOURNAL ARTICLE
Xiaoyan Xing, Yuzhou Gan, Wanxing Mo, Jian Zhang, Naidi Wang, Kai Zhang, Ke Ma, Lihua Zhang, Lin Ma, Dan Lu, Yuhui Li, Jing He
OBJECTIVES: Myositis-specific antibodies (MSAs) and myositis-associated antibodies (MAAs) are associated with distinctive dermatomyositis (DM) clinical phenotypes. The aim of this study is to explicate the clinical and immunological features of MSAs-negative DM patients. METHODS: A total of 515 individuals diagnosed with DM was screened from 2013 to 2022 and 220 DM patients were enrolled in this retrospective cohort. Clinical and laboratory data of these patients were analyzed...
February 7, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38312034/histopathological-findings-in-lung-biopsies-with-usual-interstitial-pneumonia-definition-of-a-new-classification-score-for-histological-fibrotic-stages
#19
JOURNAL ARTICLE
Mária Makovická, Adela Vrbenská, Peter Makovický, Barbora Durcová, Jozef Škarda, Vojtěch Kamarád, Mária Miklošová, Kvetoslava Rimárová, Patricie Michalčová, Klaudia Kráľová, Jozef Muri
The objective of this article is to describe and classify usual interstitial pneumonia (UIP) changes according to their relevance in the pathology of the idiopathic pulmonary fibrosis (IPF) process. In a cohort of 50 patients (25♀, 25♂) with UIP findings, the percentage ratio between fibrotic and preserved parts of the lungs was quantified. Three quantitative stages of fibrotic involvement of the lung parenchyma and concomitant changes were defined. These are initial (≤20%), advanced (21-40%), and diffuse (≥41%) fibrosis of the lungs...
January 2024: General Physiology and Biophysics
https://read.qxmd.com/read/38296310/prevalence-and-clinical-characteristics-of-patients-with-rheumatoid-arthritis-with-interstitial-lung-disease-using-unstructured-healthcare-data-and-machine-learning
#20
JOURNAL ARTICLE
Jose A Román Ivorra, Ernesto Trallero-Araguas, Maria Lopez Lasanta, Laura Cebrián, Leticia Lojo, Belén López-Muñíz, Julia Fernández-Melon, Belén Núñez, Lucia Silva-Fernández, Raúl Veiga Cabello, Pilar Ahijado, Isabel De la Morena Barrio, Nerea Costas Torrijo, Belén Safont, Enrique Ornilla, Juliana Restrepo, Arantxa Campo, Jose L Andreu, Elvira Díez, Alejandra López Robles, Elena Bollo, Diego Benavent, David Vilanova, Sara Luján Valdés, Raul Castellanos-Moreira
OBJECTIVES: Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR). METHODS: Observational case-control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019...
January 30, 2024: RMD Open
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