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Usual interstitial pneumonia

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https://www.readbyqxmd.com/read/29905415/an-unusual-presentation-of-pulmonary-lymphoma-when-diffuse-ground-glass-opacities-can-mean-anything
#1
Anna Stainer, Paola Faverio, Francesca Bono, Alberto Pesci
Primary lung lymphoma (PLL) is a rare type of lymphoma confined to the lung at the time of diagnosis. Pulmonary diffuse large B cells lymphoma (P-DLBCL) is the second most common type of PLL and it usually appears radiologically as solitary or multiple nodules or areas of consolidation. We present the case of a 63-year-old Caucasian male who developed severe acute respiratory failure and diffuse ground glass opacities (GGO) on chest computerized tomography. Diffuse GGO may be the radiological expression of very different diseases, ranging from infectious processes to interstitial lung diseases (ILDs) and neoplastic diseases...
May 14, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29901529/transbronchial-lung-cryobiopsy-in-the-diagnosis-of-interstitial-lung-disease-a-retrospective-single-center-experience
#2
Roy Cho, Felix Zamora, Heidi Gibson, H Erhan Dincer
BACKGROUND: Surgical lung biopsy (SLB) is the gold standard to aid diagnosis of interstitial lung disease (ILD). Complication rates are restrictive as routine approach for all patients with ILD. Transbronchial lung cryobiopsy (TBLC) is presumed to be a safe, less invasive alternative to assist multidisciplinary discussions regarding the diagnosis of ILD. Varying practice patterns and lack of consistent guidelines prohibit wide support of this technique. The purpose of this study was to evaluate safety and diagnostic yield of TBLC, with highlight of distinct technical features, in ILD...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29897160/clinical-behaviour-of-patients-exposed-to-organic-dust-and-diagnosed-with-idiopathic-pulmonary-fibrosis
#3
Laurens J De Sadeleer, Stijn E Verleden, Els De Dycker, Jonas Yserbyt, Johny A Verschakelen, Eric K Verbeken, Benoit Nemery, Geert M Verleden, Frederik Hermans, Bart M Vanaudenaerde, Wim A Wuyts
BACKGROUND AND OBJECTIVE: Although idiopathic pulmonary fibrosis (IPF) patients experience a worse survival compared with chronic hypersensitivity pneumonitis (CHP), organic dust exposure is a known risk factor for both IPF and CHP. METHODS: We divided patients diagnosed with IPF, based on their exposure to moulds/birds (absent: group A; present: group B). We retrospectively compared pulmonary function and survival between groups A and B, and a separate CHP cohort (group C)...
June 13, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29896291/impact-of-interstitial-lung-disease-classification-on-the-development-of-acute-exacerbation-of-interstitial-lung-disease-and-prognosis-in-patients-with-stage-iii-non-small-cell-lung-cancer-and-interstitial-lung-disease-treated-with-chemoradiotherapy
#4
Haruki Kobayashi, Tateaki Naito, Katsuhiro Omae, Shota Omori, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Toshiaki Takahashi
Introduction: Data on the efficacy and risk of curative-intent chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer (NSCLC) and interstitial lung disease (ILD) are limited. The aim of this study was to explore the impact of ILD classification on acute exacerbation (AE) of ILD and prognosis in patients with stage III NSCLC and ILD treated with chemoradiotherapy. Materials and methods: We retrospectively reviewed the medical records of patients with stage III NSCLC and ILD treated with curative-intent chemoradiotherapy as the first-line treatment at the Shizuoka Cancer Center between June 2009 and May 2014...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29894993/transbronchial-lung-cryobiopsy-in-interstitial-lung-diseases-best-practice
#5
Sara Colella, Maik Haentschel, Pallav Shah, Venerino Poletti, Jürgen Hetzel
The lung biopsy in interstitial lung disease (ILD) represents an important diagnostic step when the clinical and radiological data are insufficient for a firm diagnosis. A growing body of evidence suggests the utility of transbronchial lung cryobiopsy (TBLC) in the diagnostic algorithm of ILD as it allows, compared to transbronchial lung biopsy with conventional forceps, a better identification of complex histological patterns - such as usual interstitial pneumonia - and can provide information which has a clinical impact on the multidisciplinary discussion similar to that provided by surgical lung biopsy...
June 12, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29879213/pre-existing-interstitial-lung-disease-as-a-risk-factor-for-pneumonitis-associated-with-ramucirumab-and-paclitaxel-in-patients-with-gastric-cancer-the-impact-of-usual-interstitial-pneumonia
#6
Nobuyuki Koyama, Sou Katayanagi, Shigeyuki Kawachi
OBJECTIVE: Combination treatment with ramucirumab and paclitaxel shows significant efficacy in patients with advanced gastric cancer as a second-line standard therapy. However, limited information is available about the development of pneumonitis associated with this treatment in clinical practice. This study aimed to characterize this form of pneumonitis and identify the risk factors for its onset. METHODS: We retrospectively analyzed the medical records of 44 patients with gastric cancer who received combination treatment with ramucirumab and paclitaxel from 2016 to 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29806092/the-lung-in-rheumatoid-arthritis-focus-on-interstitial-lung-disease
#7
REVIEW
Paolo Spagnolo, Joyce C Lee, Nicola Sverzellati, Giulio Rossi, Vincent Cottin
Interstitial lung disease (ILD) is an increasingly recognized complication of rheumatoid arthritis (RA) and is associated with significant morbidity and mortality. In addition, approximately one-third of patients have subclinical disease with varying degrees of functional impairment. While risk factors for RA-ILD are well established (e.g., older age, male gender, ever smoking history and seropositivity to rheumatoid factor and anti-cyclic citrullinated peptide antibodies) little is known about optimal disease assessment, treatment and monitoring, particularly in patients with progressive disease...
May 27, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29785507/assessing-mortality-models-in-systemic-sclerosis-related-interstitial-lung-disease
#8
Robert L Mango, Eric L Matteson, Cynthia S Crowson, Jay H Ryu, Ashima Makol
PURPOSE: The gender, age, and lung physiology (GAP) model, interstitial lung diseases-GAP (ILD-GAP) model, and the smoking history, age, and diffusion capacity of the lung (SADL) model were compared using a systemic sclerosis-ILD (SSc-ILD) cohort to evaluate which best determined prognosis. METHODS: The models were applied to a cohort of 179 patients with SSc seen at a tertiary care center within 1 year of ILD diagnosis. Demographics, clinical characteristics, and mortality were recorded...
May 21, 2018: Lung
https://www.readbyqxmd.com/read/29784045/occupational-risk-factors-for-idiopathic-pulmonary-fibrosis-in-southern-europe-a-case-control-study
#9
Giulia Paolocci, Ilenia Folletti, Kjell Torén, Magnus Ekström, Marco Dell'Omo, Giacomo Muzi, Nicola Murgia
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Occupational risk factors have been proposed to be associated with UIP. The aim of this case-control study is to evaluate the relationship between UIP pattern and occupational exposure in Southern Europe. METHODS: Sixty nine cases with a UIP radiological pattern at CT-scan were selected from a clinical database of the University Hospital of Perugia, Umbria, between January 2010 and December 2013...
May 21, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29767784/imaging-features-of-typical-usual-interstitial-pneumonia-uip
#10
Joanna G Escalon, David A Lynch
No abstract text is available yet for this article.
May 14, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29764748/anticancer-drug-treatment-for-advanced-lung-cancer-with-interstitial-lung-disease
#11
REVIEW
Kohei Otsubo, Isamu Okamoto, Naoki Hamada, Yoichi Nakanishi
Interstitial lung disease (ILD) is a risk factor for lung cancer development and is frequently observed in patients with lung cancer. Individuals with ILD have been excluded from most prospective clinical trials of lung cancer therapies because of the risk of ILD acute exacerbation. Thus, the optimal anticancer drug treatment for such patients has yet to be established. Tyrosine kinase inhibitors are avoided for the treatment of advanced non-small cell lung cancer (NSCLC) with ILD because of the concern of acute exacerbation, and information on the effects of immune-checkpoint inhibitors is limited in these patients...
April 13, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29764379/identification-of-usual-interstitial-pneumonia-pattern-using-rna-seq-and-machine-learning-challenges-and-solutions
#12
Yoonha Choi, Tiffany Ting Liu, Daniel G Pankratz, Thomas V Colby, Neil M Barth, David A Lynch, P Sean Walsh, Ganesh Raghu, Giulia C Kennedy, Jing Huang
BACKGROUND: We developed a classifier using RNA sequencing data that identifies the usual interstitial pneumonia (UIP) pattern for the diagnosis of idiopathic pulmonary fibrosis. We addressed significant challenges, including limited sample size, biological and technical sample heterogeneity, and reagent and assay batch effects. RESULTS: We identified inter- and intra-patient heterogeneity, particularly within the non-UIP group. The models classified UIP on transbronchial biopsy samples with a receiver-operating characteristic area under the curve of ~ 0...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29740120/the-clinical-characteristics-and-outcomes-of-follicular-bronchiolitis-in-chinese-adult-patients
#13
Ju Lu, Miao Ma, Qi Zhao, Fanqing Meng, Dongmei Wang, Hourong Cai, Mengshu Cao
Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31-55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737055/-a-retrospective-analysis-of-clinical-features-of-interstitial-pneumonia-with-autoimmune-features
#14
Bei-Bei Cui, Yang Wu, Huan Liu, Yi-Dan Chen, Qi-Bing Xie, Geng Yin
OBJECTIVE: To analyze the clinical features of interstitial pneumonia with autoimmune features (IPAF) and the correlation between them. METHODS: We respectively analyzed the patients with interstitial lung disease (ILD) admitted in our hospital from January 2014 to January 2017. The patients who met all priori requirements and at least one feature of one domain were recuited, and the clinical features and autoimmune diseases related prognosis were analyzed. RESULTS: There were 90 patients recruited,including 38 patients completely met IPAF classification criteria and 52 patients who incompletely met...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29733782/idiopathic-pulmonary-fibrosis-what-primary-care-physicians-need-to-know
#15
REVIEW
Leslie B Tolle, Brian D Southern, Daniel A Culver, Jeffrey C Horowitz
Idiopathic pulmonary fibrosis (IPF) is a specific type of fibrosing interstitial pneumonia of unknown cause. It is usually chronic and progressive, tends to affect mainly adults over age 60, has a predilection for men, and is often fatal. The condition is still underappreciated by pulmonologists and primary care physicians. This article attempts to close that information gap by reviewing the natural course of IPF and presenting an algorithmic approach to diagnosis and treatment based on evidence-based international guidelines...
May 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29718008/correlation-between-lung-and-joint-involvement-in-patients-with-rheumatoid-arthritis-and-interstitial-lung-disease-a-cross-sectional-study
#16
Francisco Paulin, Juan Francisco Mercado, Martín Eduardo Fernández, Fabián Matías Caro, María Laura Alberti, Leandro Alberto Fassola
Background: Rheumatoid arthritis (RA) can affect the lungs in different manners, with interstitial lung disease (ILD) as the most serious manifestation. Although lung and joint compromise could be thought to evolve in parallel, there are data suggesting the opposite. In this study, we evaluated the relationship between lung and joint involvement in RA ILD. Methods: An observational cross-sectional study of RA ILD patients evaluated from January 2015 to February 2017...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29697080/series-of-rare-lung-diseases-mimicking-imaging-patterns-of-common-diffuse-parenchymal-lung-diseases
#17
Kiran Batra, Riham Dessouky, Yasmeen M Butt, Vibhor Wadhwa, Jose R Torrealba, Craig Glazer
Diffuse parenchymal lung diseases (DPLDs) encompass a variety of restrictive and obstructive lung pathologies. In this article, the authors discuss a series of rare pulmonary entities and their high-resolution computed tomography imaging appearances, which can mimic more commonly encountered patterns of DPLDs. These cases highlight the importance of surgical lung biopsies in patients with imaging findings that do not show typical imaging features of usual interstitial pneumonia.
May 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29693937/point-of-care-lung-ultrasound
#18
Makoto Sera
The evaluation of the lung has usually been considered off-limits for ultrasound, because ultrasound energy is rapidly dissipated by air. Lung ultrasound is not useful for the evaluation of the pulmonary parenchyma and the pleural line. However ultrasound machines have become more portable, with decreased start-up time, while simultaneously providing improved image quality and ease of image acquisition. Additionally, lung ultrasound is highly accurate for the diagnosis of pneumothorax, hemothorax. pleural effusions, pulmonary edema (cardiogenic or noncardiogenic), interstitial syndrome, and pneumonia...
May 2017: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/29683868/differentiating-usual-interstitial-pneumonia-from-nonspecific-interstitial-pneumonia-using-high-resolution-computed-tomography-the-straight-edge-sign
#19
Xi Zhan, Tilman Koelsch, Steven M Montner, Allen Zhu, Rekha Vij, Jeffery J Swigris, Jonathan H Chung
PURPOSE: The purpose of this article was to determine whether a novel finding on coronal computed tomography (CT) can help differentiate usual interstitial pneumonia (UIP) from nonspecific interstitial pneumonia (NSIP) in order to obviate lung biopsy. MATERIALS AND METHODS: Two chest radiologists, blinded to clinical data, reviewed 3 preselected coronal images from CT scans, performed within 1 year of surgical lung biopsy (SLB), from 51 patients with biopsy-proven UIP and 15 with biopsy-proven NSIP...
April 21, 2018: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29644083/acute-interstitial-pneumonia-as-first-presentation-of-anti-synthetase-syndrome-an-atypical-case
#20
Kalimullah Jan, Melonie Kannamma Sriranganathan
Anti-synthetase syndrome is characterized by myositis associated with interstitial lung disease (ILD), the usual pattern of ILD being non-specific interstitial pneumonia type or usual interstitial pneumonia. We report a case of anti-synthetase syndrome presenting as acute interstitial pneumonia which is reported only once before. With this case, we emphasize the need to consider anti-synthetase syndrome even in patients presenting with acute onset ILD. Physicians should raise their index of suspicion in this clinical context as timely diagnosis, early treatment, and a multidisciplinary approach is paramount for optimal care of these patients...
April 2018: Oxford Medical Case Reports
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