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JOURNAL ARTICLE
Marjolein Drent, Petal A Wijnen, Naomi T Jessurun, Ankie M Harmsze, Otto Bekers, Aalt Bast
BACKGROUND: Pulmonary toxicity has been associated with drug use. This is often not recognized in clinical practice, and underestimated. OBJECTIVE: We aimed to establish whether polymorphisms in certain genes corresponding with a metabolic pathway of drug(s) used are associated with pulmonary toxicity in patients with suspected drug-induced interstitial lung disease (DI-ILD). METHODS: This retrospective observational study explored genetic variations in three clinically relevant cytochrome P450 (CYP) iso-enzymes (i...
March 9, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
#22
JOURNAL ARTICLE
Seda Colak, Emre Tekgoz, Ezgi Cimen Gunes, Nesrin Ocal, Deniz Dogan, Canturk Tasci, Muhammet Cinar, Sedat Yilmaz
INTRODUCTION: Interstitial lung disease is one of the most critical manifestations of connective tissue diseases that may cause morbidity and mortality. This study aimed to evaluate the clinical and demographic characteristics and treatment of the patients with connective tissue disease-related interstitial lung disease. METHOD: This retrospective observational study included patients from the Gulhane Rheumatology Interstitial Lung Disease cohort between October 2016 and June 2023...
March 9, 2024: Clinical Rheumatology
#23
JOURNAL ARTICLE
Ignacio Gayá García-Manso, Juan Arenas Jiménez, Luis Hernández Blasco, Elena García Garrigós, Ester Nofuentes Pérez, Marina Sirera Matilla, Sandra Ruiz Alcaraz, Raquel García Sevila
INTRODUCTION: The new diagnostic guidelines for idiopathic pulmonary fibrosis (IPF) did not rule out the possibility of combining the radiological patterns of usual interstitial pneumonia (UIP) and probable UIP, given the similar management and diagnostic capacity. However, the prognostic implications of these patterns have not been fully elucidated, with different studies showing heterogeneous results. We applied the new criteria to a retrospective series of patients with IPF, assessing survival based on radiological patterns, findings, and their extension...
March 15, 2024: Heliyon
#24
REVIEW
J Bermudez, P Habert, B Coiffard
Interstitial lung diseases (ILD) are a heterogeneous group of respiratory diseases often related to connective tissue diseases. Some patients will develop an ILD with autoimmune features without reaching the recommended criteria for autoimmune diseases. Their management is difficult because they have both features for idiopathic and connective tissue disease. To better identify these patients, the concept of interstitial pneumonia with autoimmune features (IPAF) has been created. The diagnosis relies on ILD without identified cause and the presence of at least one defined criterion among 2 of the 3 following domains: clinic, serologic, and morphologic...
March 2, 2024: La Revue de Médecine Interne
#25
Zhen Huang, Tao Cheng, Guangwen Chen
Idiopathic pulmonary hemosiderosis (IPH) is a rare and fatal lung disease. Mycoplasma pneumoniae pneumonia (MPP) is the main community-acquired pneumonia among children aged 5 and above in China. We report the following case of IPH complicated with severe mycoplasma pneumoniae pneumonia(SMPP). An 8-year-old boy with cough and fever was diagnosed with IPH for 3 years and his chest computed tomography showed bilateral bronchopneumonia, lobular consolidation and subpleural interstitial fibrosis. As far as we know, IPH related to SMPP is rarely reported...
2024: Respiratory Medicine Case Reports
#26
MULTICENTER STUDY
Noriyuki Enomoto, Shusuke Yazawa, Yasutaka Mochizuka, Atsuki Fukada, Yuko Tanaka, Hyogo Naoi, Yuya Aono, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Mikio Toyoshima, Masato Kono, Shiro Imokawa, Takehisa Sano, Taisuke Akamatsu, Naoki Koshimizu, Koshi Yokomura, Hiroyuki Matsuda, Yusuke Kaida, Masahiro Shirai, Kazutaka Mori, Masafumi Masuda, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Hiroaki Sugiura, Hiromitsu Sumikawa, Masashi Kitani, Kazuhiro Tabata, Noriyoshi Ogawa, Takafumi Suda
BACKGROUND: Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they have interstitial pneumonia with autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens and the treatment response have not been fully determined. Therefore, this study was conducted to evaluate the relationship between findings on HRCT or lung histopathological specimens and the progression of interstitial pneumonia in patients with IPAF...
April 2024: Respiratory Medicine
#27
Bingu Shiv Kiran Reddy, Babaji Ghewade, Ulhas Jadhav, Pankaj Wagh
Cryptogenic organising pneumonia (COP) is a form of idiopathic diffuse interstitial lung disease (ILD) that develops in response to a variety of unknown irritants. An essential component of the development of organising pneumonia (OP) is damage to type II pneumocytes and the alveolar basement membrane. An autoimmune illness called systemic sclerosis (SSc) has a significant death rate from cardiopulmonary involvement such as pulmonary hypertension and ILD. Arthritis is an autoimmune disorder, in which the patients experience extra-articular symptoms such as ILD during the course of their disease, and COP frequently coexists with these conditions...
January 2024: Curēus
#28
JOURNAL ARTICLE
Jake Vernon-Elliot, Jyotika Devi Prasad, Asha Bonney
Chronic eosinophilic pneumonia (CEP) is a rare, idiopathic interstitial lung disease characterised by the accumulation of eosinophils in the pulmonary interstitia and alveoli. Patients with CEP respond well to systemic corticosteroid therapy and infrequently progress to end-stage lung disease. We report a case of a woman in her 40s with previously stable, steroid-responsive CEP who experienced a critical deterioration of her CEP at 25 weeks of gestation during her third pregnancy. The patient was admitted to the intensive care unit due to respiratory failure requiring intubation and mechanical ventilation...
February 23, 2024: BMJ Case Reports
#29
JOURNAL ARTICLE
Miyu Imai, Hiroko Okabayashi, Kimitaka Akaike, Shohei Hamada, Aiko Masunaga, Hidenori Ichiyasu, Takuro Sakagami
BACKGROUND: Gastrointestinal symptoms, such as diarrhea and nausea, are common adverse events associated with nintedanib. Systemic sclerosis is associated with a high prevalence of gastrointestinal symptoms that may increase with nintedanib administration. In clinical practice, we aimed to determine whether patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) experience more adverse gastrointestinal events associated with nintedanib than patients with idiopathic interstitial pneumonias (IIPs)...
February 22, 2024: Respiratory Investigation
#30
JOURNAL ARTICLE
Jia-Jia Fan, Jin-Min Gu, Si-Yao Xiao, Ming-Yue Jia, Gui-Ling Han
OBJECTIVE: This study aimed to identify clinical characteristics associated with the prevalence of progressive pulmonary fibrosis (PPF) in interstitial lung disease (ILD) and to develop a prognostic nomogram model for clinical use. METHODS: In this single-centered, retrospective study, we enrolled ILD patients with relatively comprehensive clinical data and assessed the incidence of PPF within a year using collected demographics, laboratory data, high-resolution computed tomography (HRCT), and pulmonary function test (PFT) results...
2024: Frontiers in Medicine
#31
JOURNAL ARTICLE
Beatriz Guillen-Guio, Megan L Paynton, Richard J Allen, Daniel P W Chin, Lauren J Donoghue, Amy Stockwell, Olivia C Leavy, Tamara Hernandez-Beeftink, Carl Reynolds, Paul Cullinan, Fernando Martinez, Helen L Booth, William A Fahy, Ian P Hall, Simon P Hart, Mike R Hill, Nik Hirani, Richard B Hubbard, Robin J McAnulty, Ann B Millar, Vidya Navaratnam, Eunice Oballa, Helen Parfrey, Gauri Saini, Ian Sayers, Martin D Tobin, Moira K B Whyte, Ayodeji Adegunsoye, Naftali Kaminski, Shwu-Fan Ma, Mary E Strek, Yingze Zhang, Tasha E Fingerlin, Maria Molina-Molina, Margaret Neighbors, X Rebecca Sheng, Justin M Oldham, Toby M Maher, Philip L Molyneaux, Carlos Flores, Imre Noth, David A Schwartz, Brian L Yaspan, R Gisli Jenkins, Louise V Wain, Edward J Hollox
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and a prior association of the HLA-DQB1 gene with idiopathic fibrotic interstitial pneumonia (including IPF) has been reported. Owing to the important role that the human leukocyte antigen (HLA) region plays in the immune response, here we evaluated if HLA genetic variation was associated specifically with IPF risk...
January 2024: ERJ Open Research
#32
JOURNAL ARTICLE
Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying
As an interstitial fibrosis disease characterized by diffuse alveolitis and structural alveolar disorders, idiopathic pulmonary fibrosis (IPF) has high lethality but lacks limited therapeutic drugs. A hospital preparation used for the treatment of viral pneumonia, Qingfei Tongluo mixture (QFTL), is rumored to have protective effects against inflammatory and respiratory disease. This study aims to confirm whether it has a therapeutic effect on bleomycin-induced IPF in rats and to elucidate its mechanism of action...
2024: Mediators of Inflammation
#33
REVIEW
Rosita M Shah, Ana M Kolansky, Seth Kligerman
While idiopathic pulmonary fibrosis (IPF) is the most common type of fibrotic lung disease, there are numerous other causes of pulmonary fibrosis that are often characterized by lung injury and inflammation. Although often gradually progressive and responsive to immune modulation, some cases may progress rapidly with reduced survival rates (similar to IPF) and with imaging features that overlap with IPF, including usual interstitial pneumonia (UIP)-pattern disease characterized by peripheral and basilar predominant reticulation, honeycombing, and traction bronchiectasis or bronchiolectasis...
February 2024: Radiology. Cardiothoracic imaging
#34
JOURNAL ARTICLE
Yisha Ye, Chor-Wing Sing, Richard Hubbard, David Chi Leung Lam, Hang-Long Li, Gloria Hoi-Yee Li, Shun-Cheong Ho, Ching Lung Cheung
BACKGROUND: Published data on the epidemiology of interstitial lung disease (ILD) in Asia is scarce. Understanding the epidemiology is important for authorities in the health management planning. This study aimed to estimate the prevalence, incidence, and survival of ILD in Hong Kong from 2005 to 2020 and evaluate the change of trend over time. METHODS: In this retrospective cohort study, we identified ILD patients between 2005 and 2020 using a territory-wide electronic health record database...
January 2024: The Lancet Regional Health. Western Pacific
#35
JOURNAL ARTICLE
Cécile Chenivesse, Sarah Gephine, Martin Dornbierer, Victor Valentin, Olivier Le Rouzic, Lidwine Wémeau, Jean-Marie Grosbois
BACKGROUND: Our objective was to evaluate the short-, medium- and long-term benefits of home-based pulmonary rehabilitation (PR) on the physical and affective components of dyspnoea in people with fibrotic idiopathic interstitial pneumonias (f-IIPs). Anxiety and depressive symptoms, fatigue, health-related quality of life and exercise tolerance were also assessed. METHODS: Data on 166 individuals with f-IIPs who enrolled in an 8-week home-based PR programme (weekly supervised 90-min session) were retrospectively analysed...
January 2024: ERJ Open Research
#36
JOURNAL ARTICLE
Marcello Chang, Joshua J Reicher, Angad Kalra, Michael Muelly, Yousef Ahmad
We previously validated Fibresolve, a machine learning classifier system that non-invasively predicts idiopathic pulmonary fibrosis (IPF) diagnosis. The system incorporates an automated deep learning algorithm that analyzes chest computed tomography (CT) imaging to assess for features associated with idiopathic pulmonary fibrosis. Here, we assess performance in assessment of patterns beyond those that are characteristic features of usual interstitial pneumonia (UIP) pattern. The machine learning classifier was previously developed and validated using standard training, validation, and test sets, with clinical plus pathologically determined ground truth...
January 11, 2024: J Imaging Inform Med
#37
REVIEW
Gaetano Rea, Marialuisa Bocchino, Roberta Lieto, Roberta Eufrasia Ledda, Michele D'Alto, Marco Sperandeo, Raffaella Lucci, Patrizio Pasquinelli, Stefano Sanduzzi Zamparelli, Giorgio Bocchini, Tullio Valente, Giacomo Sica
Hypersensitivity pneumonitis (HP) is a diffuse parenchymal lung disease (DLPD) characterized by complex interstitial lung damage with polymorphic and protean inflammatory aspects affecting lung tissue targets including small airways, the interstitium, alveolar compartments and vascular structures. HP shares clinical and often radiological features with other lung diseases in acute or chronic forms. In its natural temporal evolution, if specific therapy is not initiated promptly, HP leads to progressive fibrotic damage with reduced lung volumes and impaired gas exchange...
January 30, 2024: Journal of Clinical Medicine
#38
JOURNAL ARTICLE
Mária Makovická, Adela Vrbenská, Peter Makovický, Barbora Durcová, Jozef Škarda, Vojtěch Kamarád, Mária Miklošová, Kvetoslava Rimárová, Patricie Michalčová, Klaudia Kráľová, Jozef Muri
The objective of this article is to describe and classify usual interstitial pneumonia (UIP) changes according to their relevance in the pathology of the idiopathic pulmonary fibrosis (IPF) process. In a cohort of 50 patients (25♀, 25♂) with UIP findings, the percentage ratio between fibrotic and preserved parts of the lungs was quantified. Three quantitative stages of fibrotic involvement of the lung parenchyma and concomitant changes were defined. These are initial (≤20%), advanced (21-40%), and diffuse (≥41%) fibrosis of the lungs...
January 2024: General Physiology and Biophysics
#39
JOURNAL ARTICLE
Mona Nili, Andrea Steffens, Amy Anderson, Lee Brekke, Mary Grace Johnson, Phani Veeranki, Amy L Olson
BACKGROUND: Fibrosing interstitial lung disease (ILD) encompasses more than 200 diverse pulmonary disorders, of which up to 40% become progressive. The 4 underlying ILD types most likely to result in progression are unclassified ILD/idiopathic interstitial pneumonia (IIP), autoimmune ILDs, exposure-related ILD/hypersensitivity pneumonitis, and sarcoidosis. OBJECTIVE: To compare health care resource utilization (HCRU) and costs among patients with fibrosing ILD that has progressed ("progressive" fibrosing cohort) vs patients whose fibrosis did not meet criteria set for progression ("not yet progressed" cohort)...
February 3, 2024: Journal of Managed Care & Specialty Pharmacy
#40
JOURNAL ARTICLE
Yu-Wan Liao, Ming-Cheng Liu, Yu-Cheng Wu, Chiann-Yi Hsu, Wen-Nan Huang, Yi-Hsing Chen, Pin-Kuei Fu
BACKGROUND: The diagnostic process for fibrotic interstitial lung disease (F-ILD) is notably intricate, necessitating a multidisciplinary discussion to achieve consensus based on both clinical and radiological features. This study investigated the shared and distinctive long-term mortality predictors among the two primary phenotypes of F-ILD, namely idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated interstitial lung disease (CTD-ILD). METHODS: We included patients with F-ILD diagnosed from December 2018 to December 2019 and conducted follow-up assessments until February 2023...
January 30, 2024: European Journal of Medical Research
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