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Idiopathic interstitial pneumonia

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https://www.readbyqxmd.com/read/29928060/clinical-significance-of-myeloperoxidase-anti-neutrophil-cytoplasmic-antibody-in-idiopathic-interstitial-pneumonias
#1
Hironao Hozumi, Yoshiyuki Oyama, Hideki Yasui, Yuzo Suzuki, Masato Kono, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda
OBJECTIVE: Although a possible association among myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA), microscopic polyangiitis (MPA), and idiopathic pulmonary fibrosis (IPF) has been suggested, the clinical significance of MPO-ANCA in idiopathic interstitial pneumonias (IIPs), including IPF and non-IPF, remains unclear. We aimed to investigate the frequency of MPO-ANCA positivity, as well as MPA incidence and risk factors for development in patients initially diagnosed with IIP...
2018: PloS One
https://www.readbyqxmd.com/read/29904044/cardiorespiratory-adaptation-in-a-6-minute-walk-test-by-fibrotic-idiopathic-interstitial-pneumonia-patients-who-did-or-did-not-respond-to-pulmonary-rehabilitation
#2
Baptiste Chéhère, Valérie Bougault, Cécile Chenivesse, Jean-Marie Grosbois, Benoit Wallaert
BACKGROUND: Pulmonary rehabilitation (PR) improves performance in the 6-min walk test (6MWT) in a subset of patients with fibrotic idiopathic interstitial pneumonia (f-IIP); however, a large proportion of patients do not respond to PR. AIM: To investigate the effects of a PR program on cardiorespiratory responses during a 6MWT and to identify the characteristics of patients who do not show improved performance after PR. DESIGN: An observational study...
June 14, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29904028/prognosis-and-follow-up-of-idiopathic-pulmonary-fibrosis
#3
REVIEW
Estrella Fernández Fabrellas, Ricardo Peris Sánchez, Cristina Sabater Abad, Gustavo Juan Samper
Idiopathic pulmonary fibrosis (IPF), a devastating progressive interstitial lung disease (ILD) with no known cause, is the most common and deadly of the idiopathic interstitial pneumonias. With a median survival of 3⁻5 years following diagnosis, IPF is characterized by a progressive decline in lung function and quality of life in most patients. Prognostic factors recognized classically that influence mortality include functional, clinical and radiological parameters. However, in recent years, there has also been progress in the knowledge of genetic factors and biomarkers that may be useful in the prognostic evaluation of these patients...
June 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29901014/idiopathic-interstitial-pneumonia-as-a-possible-cause-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-a-case-report
#4
Hiroshi Oiwa, Katsuhiro Ooi, Tetsu Oyama, Eiji Sugyama
There are conflicting data to date on the causal relationship between idiopathic interstitial pneumonia and antineutrophil cytoplasmic antibody (ANCA): (1) myeloperoxidase-ANCA may play a pathogenetic role in pulmonary fibrosis, or (2) pulmonary fibrosis may induce production of the antibody. In this article, we describe a case of an elderly female patient with microscopic polyangiitis that developed after positive conversion of myeloperoxidase-ANCA during the course of idiopathic interstitial pneumonia. Our experience as well as similar case reports may suggest that idiopathic interstitial pneumonia may induce production of ANCAs and even ANCA-associated vasculitis...
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29900176/effects-of-pulmonary-rehabilitation-on-daily-life-physical-activity-of-fibrotic-idiopathic-interstitial-pneumonia-patients
#5
Benoit Wallaert, Nicolas Masson, Olivier Le Rouzic, Baptiste Chéhère, Lidwine Wémeau-Stervinou, Jean-Marie Grosbois
Fibrotic idiopathic interstitial pneumonia patients derived benefit from a pulmonary rehabilitation programme in terms of exercise tolerance, anxiety, depression and quality of life without increasing their daily life physical activity http://ow.ly/WV7U30kgNkU.
April 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29897160/clinical-behaviour-of-patients-exposed-to-organic-dust-and-diagnosed-with-idiopathic-pulmonary-fibrosis
#6
Laurens J De Sadeleer, Stijn E Verleden, Els De Dycker, Jonas Yserbyt, Johny A Verschakelen, Eric K Verbeken, Benoit Nemery, Geert M Verleden, Frederik Hermans, Bart M Vanaudenaerde, Wim A Wuyts
BACKGROUND AND OBJECTIVE: Although idiopathic pulmonary fibrosis (IPF) patients experience a worse survival compared with chronic hypersensitivity pneumonitis (CHP), organic dust exposure is a known risk factor for both IPF and CHP. METHODS: We divided patients diagnosed with IPF, based on their exposure to moulds/birds (absent: group A; present: group B). We retrospectively compared pulmonary function and survival between groups A and B, and a separate CHP cohort (group C)...
June 13, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29892541/lymphocytic-interstitial-pneumonia-in-a-patient-with-mixed-connective-tissue-disease-a-case-report
#7
Chin-Wei Kuo, Kung-Chao Chang, Han-Yu Chang, Tang-Hsiu Huang
Lymphocytic interstitial pneumonia (LIP) is an uncommon interstitial lung disease that is characterized by an interstitial infiltrate of lymphoplasmacytic cells. While idiopathic LIP appears to be extremely rare, most reported cases of LIP have been associated with coexisting immune derangements, particularly autoimmune diseases such as Sjögren's syndrome. In this report, we describe the presentation of LIP in a patient with underlying mixed connective tissue disease.
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29879078/treatment-rationale-and-design-of-the-spiral-study-a-phase-ii-trial-of-osimertinib-in-elderly-epidermal-growth-factor-receptor-t790m-positive-nonsmall-cell-lung-cancer-patients-who-progressed-during-prior-egfr-tki-treatment
#8
Junji Uchino, Akira Nakao, Nobuyo Tamiya, Yoshiko Kaneko, Tadaaki Yamada, Kenichi Yoshimura, Masaki Fujita, Koichi Takayama
BACKGROUND: Advances in epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment led to research on the mechanism of the resistance have revealed that an occurrence of T790M gene mutation generated in exon 20 of the EGFR gene is associated with approximately 50% to 60% of observed resistance. Osimertinib, a 3rd-generation EGFR-TKI, has been shown to be effective against both EGFR tyrosine kinase inhibitor-sensitizing and T790M resistance mutations. In this study, we prospectively investigate the efficacy and safety of osimertinib in elderly patients aged ≥75 years, with ineffective prior EGFR-TKI treatment or with recurrence of EGFR-TKI mutation-positive or T790M mutation-positive nonsmall-cell lung cancer...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29873202/prognostic-evaluation-of-serum-ferritin-in-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#9
Noriyuki Enomoto, Yoshiyuki Oyama, Yasunori Enomoto, Masashi Mikamo, Masato Karayama, Hironao Hozumi, Yuzo Suzuki, Masato Kono, Kazuki Furuhashi, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda
BACKGROUND: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) has an extremely poor prognosis. The role of ferritin in the pathogenesis of AE-IPF is not well known while serum ferritin is a key prognostic indicator for patients with clinically amyopathic dermatomyositis with rapidly progressive interstitial pneumonia. OBJECTIVE: To elucidate the clinical importance of serum ferritin in patients with AE-IPF. METHODS: Thirty-seven patients (48 episodes), who were diagnosed with AE-IPF and treated at our hospital between 1997 and 2015, were retrospectively studied...
June 5, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29873047/idiopathic-pulmonary-fibrosis-pathophysiological-data
#10
Khadija Ayed, Raja Serairi Beji, Saloua Jameleddine
Idiopathic pulmonary fibrosis is the most common of the idiopathic interstitial pneumonias. The role of inflammation in idiopathic pulmonary fibrosis (IPF) is controversial. If inflammation were critical to the disease process, lung pathology would demonstrate an influx of inflammatory cells, and that the disease would respond to immunosuppression. The classic pathology does not display substantial inflammation, and no modulation of the immune system is effective as treatment. Recent data suggest that the pathophysiology of the disease is more a product of fibroblast dysfunction than of dysregulated inflammation...
August 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29806092/the-lung-in-rheumatoid-arthritis-focus-on-interstitial-lung-disease
#11
REVIEW
Paolo Spagnolo, Joyce C Lee, Nicola Sverzellati, Giulio Rossi, Vincent Cottin
Interstitial lung disease (ILD) is an increasingly recognized complication of rheumatoid arthritis (RA) and is associated with significant morbidity and mortality. In addition, approximately one-third of patients have subclinical disease with varying degrees of functional impairment. While risk factors for RA-ILD are well established (e.g., older age, male gender, ever smoking history and seropositivity to rheumatoid factor and anti-cyclic citrullinated peptide antibodies) little is known about optimal disease assessment, treatment and monitoring, particularly in patients with progressive disease...
May 27, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29795561/association-of-serum-high-mobility-group-box-protein-1-level-with-outcomes-of-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-and-fibrosing-nonspecific-interstitial-pneumonia
#12
Hiroshige Shimizu, Susumu Sakamoto, Takuma Isshiki, Kenta Furuya, Atsuko Kurosaki, Sakae Homma
BACKGROUND AND OBJECTIVE: High-mobility group box 1 (HMGB1) protein is important in acute lung injury. However, the role of HMGB-1 in acute exacerbation of fibrosing interstitial pneumonia (AE-FIP) has not been adequately studied. METHODS: We prospectively measured serum HMGB1 level from disease onset to day 7 in 36 patients with AE-FIP6 patients had missing data because of early death (within 7 days). We then examined the association of HMGB1 level and outcome, and the associations of rhTM with HMGB1 level and outcome in 19 patients who were treated with rhTM (rhTM group) and 11 patients who were not (control group)...
2018: PloS One
https://www.readbyqxmd.com/read/29784045/occupational-risk-factors-for-idiopathic-pulmonary-fibrosis-in-southern-europe-a-case-control-study
#13
Giulia Paolocci, Ilenia Folletti, Kjell Torén, Magnus Ekström, Marco Dell'Omo, Giacomo Muzi, Nicola Murgia
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Occupational risk factors have been proposed to be associated with UIP. The aim of this case-control study is to evaluate the relationship between UIP pattern and occupational exposure in Southern Europe. METHODS: Sixty nine cases with a UIP radiological pattern at CT-scan were selected from a clinical database of the University Hospital of Perugia, Umbria, between January 2010 and December 2013...
May 21, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29764379/identification-of-usual-interstitial-pneumonia-pattern-using-rna-seq-and-machine-learning-challenges-and-solutions
#14
Yoonha Choi, Tiffany Ting Liu, Daniel G Pankratz, Thomas V Colby, Neil M Barth, David A Lynch, P Sean Walsh, Ganesh Raghu, Giulia C Kennedy, Jing Huang
BACKGROUND: We developed a classifier using RNA sequencing data that identifies the usual interstitial pneumonia (UIP) pattern for the diagnosis of idiopathic pulmonary fibrosis. We addressed significant challenges, including limited sample size, biological and technical sample heterogeneity, and reagent and assay batch effects. RESULTS: We identified inter- and intra-patient heterogeneity, particularly within the non-UIP group. The models classified UIP on transbronchial biopsy samples with a receiver-operating characteristic area under the curve of ~ 0...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29740120/the-clinical-characteristics-and-outcomes-of-follicular-bronchiolitis-in-chinese-adult-patients
#15
Ju Lu, Miao Ma, Qi Zhao, Fanqing Meng, Dongmei Wang, Hourong Cai, Mengshu Cao
Follicular bronchiolitis (FB) is a rare interstitial lung disease (ILD) and has been reported in diverse clinical contexts. Six FB patients demonstrated by surgical lung biopsy (SLB) were reviewed between 2009 and 2017 from Nanjing Drum Tower Hospital in China. The average age of subjects was 42 years old (range: 31-55 years). The clinical symptoms were very mild. The laboratory findings showed elevated Erythrocyte sedimentation rate (ESR) and serum globulin and anemia. Pulmonary function tests were normal in four cases...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733782/idiopathic-pulmonary-fibrosis-what-primary-care-physicians-need-to-know
#16
REVIEW
Leslie B Tolle, Brian D Southern, Daniel A Culver, Jeffrey C Horowitz
Idiopathic pulmonary fibrosis (IPF) is a specific type of fibrosing interstitial pneumonia of unknown cause. It is usually chronic and progressive, tends to affect mainly adults over age 60, has a predilection for men, and is often fatal. The condition is still underappreciated by pulmonologists and primary care physicians. This article attempts to close that information gap by reviewing the natural course of IPF and presenting an algorithmic approach to diagnosis and treatment based on evidence-based international guidelines...
May 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29728109/a-serological-biomarker-of-versican-degradation-is-associated-with-mortality-following-acute-exacerbations-of-idiopathic-interstitial-pneumonia
#17
Jannie M B Sand, Yoshinori Tanino, Morten A Karsdal, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Xintao Wang, Diana J Leeming, Mitsuru Munakata
BACKGROUND: Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease activity, thus we hypothesized that ECM remodeling was altered during acute exacerbations and investigated this by serological neo-epitope biomarkers. METHODS: Patients who were sequentially admitted to the hospital with acute exacerbations of IIP were retrospectively analyzed for ECM remodeling at time of exacerbation (AE-IIP) and at clinical stability (S-IIP)...
May 4, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29726062/expanded-acceptance-of-acute-exacerbation-of-nonspecific-interstitial-pneumonia-including-7-additional-cases-with-detailed-clinical-pathologic-correlation
#18
Atsushi Miyamoto, Amita Sharma, Michiya Nishino, Mari Mino-Kenudson, Osamu Matsubara, Eugene Jerome Mark
Acute exacerbation is uncommonly diagnosed in patients with nonspecific interstitial pneumonia (NSIP) and its pathologic features have received relatively little attention compared to idiopathic pulmonary fibrosis. We retrospectively studied 14 consecutive cases of histopathologically proven NSIP by surgical lung biopsy. The diagnosis of acute exacerbation was confirmed clinically. We analyzed whether four reported pathologic features, including organizing pneumonia lesion, alveolar hemorrhage, many fibroblastic foci, and focal hyaline membranes were present and suggestive of acute exacerbation of NSIP or not...
May 3, 2018: Pathology International
https://www.readbyqxmd.com/read/29696986/fibroblast-senescence-in-the-pathology-of-idiopathic-pulmonary-fibrosis
#19
David W Waters, Kaj E C Blokland, Prabuddha S Pathinayake, Janette K Burgess, Steven E Mutsaers, Cecilia M Prêle, Michael Schuliga, Christopher L Grainge, Darryl A Knight
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown cause with a median survival of only 3 years. Little is known about the mechanisms that precede the excessive collagen deposition seen in IPF, but cellular senescence has been strongly implicated in disease pathology. Senescence is a state of irreversible cell cycle arrest accompanied by an abnormal secretory profile and is thought to play a critical role in both development and wound repair. Normally, once a senescent cell has contributed to wound repair it is promptly removed from the environment via infiltrating immune cells...
April 26, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29693298/prognostic-factors-and-disease-behaviour-of-pathologically-proven-fibrotic-non-specific-interstitial-pneumonia
#20
Hideaki Yamakawa, Hideya Kitamura, Tamiko Takemura, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Tae Iwasawa, Eri Hagiwara, Shinji Sato, Takashi Ogura
BACKGROUND AND OBJECTIVE: Non-specific interstitial pneumonia (NSIP) has heterogeneous characteristics in terms of background, disease behaviour and prognosis. This study of fibrotic NSIP (f-NSIP) aimed to elucidate prognosis and disease behaviour from the viewpoint of clinical background and determine whether long-term change of pulmonary function could provide useful prognostic information. METHODS: We analysed the medical records of 157 consecutive patients diagnosed with f-NSIP by surgical lung biopsy...
April 24, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
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