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https://www.readbyqxmd.com/read/29933872/an-unusual-presentation-of-primary-myelofibrosis
#1
Prateek Tiwari, Vandana Mahajan, Kanchan Muhrerkar
Extramedullary hematopoisis (EMH) normally occurs in fetal life, but it is pathological in later life and most of the time because of underlying marrow diseases. Sometimes EMH tissue can present with large masses which can cause compressive and constitutional symptoms. They can be wrongly diagnosed as malignancy and pulmonary tuberculosis. Here in this case report we are reporting a case with mediastinal EMH because of underlying mylofibrosis.
July 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29931394/absence-of-il-17a-in-litomosoides-sigmodontis-infected-mice-influences-worm-development-and-drives-elevated-filarial-specific-ifn-%C3%AE
#2
Manuel Ritter, Vanessa Krupp, Katharina Wiszniewsky, Anna Wiszniewsky, Gnatoulma Katawa, Ruth S E Tamadaho, Achim Hoerauf, Laura E Layland
Lymphatic filariasis, onchocerciasis and loiasis are widespread neglected tropical diseases causing serious public health problems and impacting the socio-economic climate in endemic communities. More than 100 million people currently suffer from filarial infections but disease-related symptoms and infection-induced immune mechanisms are still ambiguous. Although most infected individuals have dominant Th2 and regulatory immune responses leading to a homeostatic regulated state, filarial-induced overt pathology like lymphedema, dermal pathologies or blindness can occur...
June 22, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29924013/anterior-mediastinal-leiomyosarcoma-mimicking-thymoma-a-case-report
#3
Xing Xue, Wenjie Liang, Wenjuan Zhang
RATIONALE: Mediastinal leiomyosarcoma is very rare. In this paper, we report one case of anterior mediastinal leiomyosarcoma and retrospectively review the imaging findings of previously reported cases. PATIENT CONCERNS: A 61-year-old male patient was admitted to our hospital due to the presence of a mediastinal space-occupying lesion for two years. Two years previously, chest computed tomography (CT) showed a small nodule in the anterior mediastinum. Twenty days previously, the CT examination was repeated at the local hospital due to respiratory symptoms, which showed a mass in the anterior mediastinum and interstitial inflammation of both lungs...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29908982/intracardiac-tumors-with-extracardiac-extension-diagnosed-by-eus-fna-via-ebus
#4
Terunaga Inage, Takahiro Nakajima, Yuki Sata, Taiki Fujiwara, Syunichiro Iwasawa, Yuichi Takiguchi, Yukio Nakatani, Ichiro Yoshino
Obtaining biopsies for pathological diagnosis of primary cardiac tumors is challenging due to their anatomical location and the risk of tumor embolization. Due to the difficulty of histological diagnosis and limited treatment strategies, it is not uncommon to treat patients based on radiological findings alone. However, firm pathological diagnosis may permit more appropriate treatment selection, especially for those with primary cardiac lymphoma. EUS-B-FNA is a minimally invasive modality for sampling mediastinal lymph nodes and mediastinal lesions adjacent to the esophagus...
June 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29908980/incidence-and-prognostic-significance-of-carcinoid-lymph-node-metastases
#5
Peter J Kneuertz, Mohamed K Kamel, Brendon M Stiles, Benjamin E Lee, Mohamed Rahouma, Sebron W Harrison, Nasser K Altorki, Jeffery L Port
BACKGROUND: Pulmonary carcinoid tumors are often considered indolent tumors. The prognostic significance of lymph node (LN) metastases and the need for mediastinal dissection is controversial. We sought to determine the incidence, risk factors, and prognosis of LN metastases in resected carcinoid patients. METHODS: Patients undergoing lung resection for carcinoid and removal of ≥10 LNs were identified in the National Cancer Database form 2004-2014. Typical (TC) and atypical (AC) carcinoids were included...
June 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29901607/membranoproliferative-glomerulonephritis-like-findings-for-tafro-syndrome-associated-with-an-anterior-mediastinal-tumor-a-case-report
#6
Yoshitaka Furuto, Hirotsugu Hashimoto, Hajime Horiuti, Yuko Shibuya
RATIONALE: TAFRO syndrome is a systemic inflammatory disease proposed recently from Japan. The cause of TAFRO syndrome is unclear. Moreover, the disease characteristics and kidney pathology are yet unknown well and there are few cases. Herein, we report a patient with TAFRO syndrome and present the features of the renal histopathology. PATIENT CONCERNS: A 55-year-old woman presented to our hospital with the main complaint of subacute dyspnoea. DIAGNOSIS: Physical findings included a low-grade fever and generalised oedema...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900476/mixed-adenoneuroendocrine-carcinoma-of-the-esophagogastric-junction-a-case-report
#7
Miho Yamamoto, Soji Ozawa, Kazuo Koyanagi, Junya Oguma, Akihito Kazuno, Yamato Ninomiya, Kentaro Yatabe, Kazuhito Hatanaka
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a tumor of the gastrointestinal tract that contains both exocrine and endocrine components, with each component exceeding 30% of the total tumor area. Because MANECs are exceedingly rare, no therapeutic strategies have been established yet. CASE PRESENTATION: An 81-year-old man was referred to our hospital with a 5-month history of dysphagia. Esophagogastroduodenoscopy revealed an ulcerated mass in the lower thoracic esophagus, extending up to the esophagogastric junction (33 to 40 cm from the incisors)...
June 14, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29891545/identification-of-mycobacterial-ribosomal-proteins-as-targets-for-cd4-t-cells-that-enhance-protective-immunity-in-tuberculosis
#8
Steven C Kennedy, Alison J Johnson, Sushma Bharrhan, Cecilia S Lindestam Arlehamn, Jiayong Xu, Scott J Garforth, John Chan, William R Jacobs, Alessandro Sette, Steven C Almo, Steven A Porcelli
Mycobacterium tuberculosis remains a threat to global health, and a more efficacious vaccine is needed to prevent disease caused by Mtb. We previously reported that the mycobacterial ribosome is a major target of CD4+ T cells in mice immunized with a genetically modified M. smegmatis strain (IKEPLUS), but not in mice immunized with M bovis BCG. Two specific ribosomal proteins, RplJ and RpsA, were identified as cross-reactive targets of Mtb, but the breadth of the CD4+ T cell response to Mtb ribosomes was not determined...
June 11, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29883920/dyspnoea-thoracic-pain-and-fever-in-a-young-caucasian-female-a-case-report
#9
Alessandro Giuseppe Fois, Rocco Trisolini, Giorgio Carlo Ginesu, Elisabetta Zinellu, Silvia Negri, Alessandra Cancellieri, Alessandra Garau, Pietro Pirina
INTRODUCTION: The diagnostic approach to patients with mediastinal pathology is not always simple and an improper diagnostic work-up can lead to significant diagnosis delay. PRESENTATION OF CASE: We report on the case of a young woman who was admitted to the Emergency Department complaining of thoracic pain, dyspnoea, fever and productive cough. The physical examination showed a painful swelling over the sternum's upper left margin, which had become evident 4 months earlier...
May 31, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29871678/robot-assisted-enucleation-of-large-dumbbell-shaped-esophageal-schwannoma-a-case-report
#10
Yajie Zhang, Yu Han, Jie Xiang, Hecheng Li
BACKGROUND: Esophageal schwannomas are extremely rare, with few cases reported in the literature. Traditionally, resection of esophageal schwannoma is typically performed using thoracotomy or video-assisted thoracic surgery. However, large, irregular tumors may increase the surgical difficulties of complete enucleation and lead to potential mucosal damage. Moreover, a subtotal esophagectomy cannot be avoided in some conditions. Here, we report the first case of robot-assisted enucleation of a large dumbbell-shaped esophageal schwannoma...
June 5, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29866101/solitary-metastasis-to-a-superior-mediastinal-lymph-node-after-distal-gastrectomy-for-gastric-cancer-a-case-report
#11
Naoki Kubo, Junichi Yoshizawa, Takaomi Hanaoka
BACKGROUND: Mediastinal lymph node metastases occasionally occur in patients of advanced gastric cancer of the cardia with esophageal invasion, but they rarely occur in patients with gastric cancer of other sites. This report describes a case of a solitary metastasis to t a superior mediastinal lymph node after distal gastrectomy for gastric cancer of the antrum. CASE PRESENTATION: A 70-year-old man underwent curative distal gastrectomy for advanced gastric cancer of the antrum (pT2pN2M0, stage IIB)...
June 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29850165/adenocarcinoma-arising-from-an-enteric-cyst-of-the-posterior-mediastinum
#12
Satoshi Mizoguchi, Takuro Miyazaki, Naoya Yamasaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Ryotaro Kamohara, Go Hatachi, Kuniko Abe, Takeshi Nagayasu
Mediastinal enteric cysts are rare congenital thoracic cysts. The majority of mediastinal enteric cysts occur in infants, while they are rare in adults. Although most of these cysts are benign, surgical resection is sometimes performed, and malignant changes found in enteric cysts are rare. A 52-year-old man was incidentally discovered to have a posterior mediastinal mass and we excised the mass thoracoscopically. Histopathological findings showed an enteric cyst with adenocarcinoma. Comparing the pathological and magnetic resonance imaging (MRI) findings, MRI would help to detect malignant changes in such cysts...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29850149/induction-chemoradiotherapy-versus-induction-chemotherapy-for-potentially-resectable-stage-iiia-n2-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#13
Shaodong Tong, Zhaohui Qin, Minghui Wan, Longzhen Zhang, Yan Cui, Yuanhu Yao
Background: Non-small cell lung cancer (NSCLC) accounts for 85% to 90% of lung cancer cases. At diagnosis, around 30% of NSCLC patients are already at stage IIIA (N2). One standard treatment for this stage is induction chemotherapy followed by surgery, whether induction chemoradiotherapy is superior to induction chemotherapy remains uncertain. We therefore performed a systematic review and meta-analysis of published randomized control trials to evaluate the therapeutic efficacy and toxicity of induction chemoradiotherapy versus induction chemotherapy for potentially resectable stage IIIA (N2) NSCLC...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29850111/clinical-and-molecular-characteristics-of-unicentric-mediastinal-castleman-disease
#14
Antoine Legras, Anne Tallet, Audrey Didelot, Aurélie Cazes, Claire Danel, Angela Hin, Raphaël Borie, Bruno Crestani, Yves Castier, Patrick Bagan, Françoise Le Pimpec-Barthes, Marc Riquet, Hélène Blons, Pierre Mordant
Background: Unicentric mediastinal Castleman disease (CD) is a rare condition, poorly characterized due to the small number of cases and the absence of genomic study. We analyzed clinical, radiological, histological and genomic patterns associated with mediastinal CD in a substantial case series. Methods: We retrospectively reviewed cases of unicentric mediastinal CD managed in 2 French thoracic surgery departments between 1988 and 2012. Clinical, radiological, surgical and pathological data were recorded...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29796007/b-chronic-lymphocytic-leukemia-showed-triple-transformation-to-diffuse-large-b-cell-cd20-negative-and-t-cell-neoplasm-during-ofatumumab-treatment-a-case-report
#15
Osamu Imataki, Makiko Uemura
Background: Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggressive lymphoma such as the diffuse large B-cell (DLBCL) type, also known as Richter's syndrome. Case presentation: We treated a 69-year-old Japanese male who was histologically diagnosed with Richter's syndrome after 6 years of CLL. His lymphadenopathy had systemically progressed for years, with lymphocyte counts of less than 10,000 cells/μL and a disease status of Rai classification stage I and Binet classification B...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29791206/effect-of-ct-window-settings-on-size-measurements-of-the-solid-component-in-sub-solid-nodules-evaluation-of-prediction-efficacy-of-the-degree-of-pathological-malignancy-in-lung-adenocarcinoma
#16
Shi-Yuan Liu, Qiong Li, Ya-Feng Gu, Li Fan, Qing-Chu Li, Yi Xiao
To investigate the predictive value of size measurements of the solid components in pulmonary subsolid nodules with different CT window settings and to evaluate the degree of pathological malignancy in lung adenocarcinoma.  Methods: The preoperative chest CT images and pathological data of 125 patients were retrospectively evaluated. The analysis included 127 surgically resected lung adenocarcinomas that manifested as subsolid nodules. All subsolid nodules were divided into two groups: 69 in group A, including 22 adenocarcinomas in situ (AIS) and 47 minimally invasive adenocarcinomas (MIA); 58 in group B that included invasive pulmonary adenocarcinomas (IPA)...
May 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29760926/diffuse-endobronchial-metastasis-from-sigmoid-carcinoma-presenting-as-wheezing-and-respiratory-failure
#17
Nattawat Jantarangsi, Poonchavist Chantranuwatana, Naricha Chirakalwasan
A 66-year-old Thai man with underlying asthma, history of traumatic right haemothorax, and sigmoid carcinoma with bladder invasion developed productive cough, whitish sputum, dyspnoea, and wheezing for 2 months. Physical examination showed generalized expiratory wheezing in both lungs. Computed tomography scan of the chest revealed diffuse thickening of bronchial wall, predominantly at lower lobes; several various sizes of pulmonary nodules; diffuse interlobular septal thickening; multiple enlarged mediastinal lymph nodes and hilar lymph nodes; and right pleural effusion...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29757564/-re-operation-treatment-in-uremic-patients-complicated-with-persistent-secondary-hyperparathyroidism-after-parathyroidectomy-with-autotransplantation
#18
Shao Jun Bo, Xian Fa Xu, Chuan Ya Qiu, Tian Tian Wang, Yu Dong Ning, Hong Yue Li
Objective: To analyze the clinical profile and therapeutic effect of re-operation treatment in uremic patients complicated with persistent secondary hyperparathyroidism(SHPT)after parathyroidectomy with autotransplantation. Method: Twelve persistent SHPT patients who were treated with reoperation of paramyroidectomy(PTX)were enrolled in this study during the period from Jan 2014 to Jul 2017 in our hospital.We evaluated the location of the remaining parathyroid glands by ultrasonography,dual-phase 99 Tcm-sestamibi scintigraphy,CT and MR imaging of the neck before the operation...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29756323/primary-mediastinal-histiocytic-sarcoma-presenting-as-pleural-effusion
#19
Jie-Yang Jhuang, Wei-Yu Chen, Shih-Sung Chuang
Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphological and immunophenotypic features of mature tissue histiocytes. As HS may mimic non-Hodgkin lymphoma (NHL) pathologically, before the era of immunohistochemistry, many previously reported cases were misdiagnosed NHL. Up to date, there are only a few reports delineating the cytological features in fine-needle aspiration or bronchoalveolar lavage, but not in the effusion fluid yet. Herein, we report the case of a 61-year-old male with a mediastinal tumor presenting with malignant pleural effusion...
May 13, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29756249/value-of-ct-added-to-ultrasonography-for-the-diagnosis-of-lymph-node-metastasis-in-patients-with-thyroid-cancer
#20
Younghen Lee, Ji-Hoon Kim, Jung Hwan Baek, So Lyung Jung, Sun-Won Park, Jinna Kim, Tae Jin Yun, Eun Ju Ha, Kyu Eun Lee, Soon Young Kwon, Kyung-Sook Yang, Dong Gyu Na
BACKGROUND: The benefit of CT for the diagnosis of lymph node metastasis in patients with thyroid cancer is still unclear. METHODS: Three hundred fifty-one patients with thyroid cancers from 7 hospitals were prospectively enrolled in order to compare diagnostic performance between a combination of ultrasound and CT (ultrasound/CT) and ultrasound alone for prediction of lymph node metastasis and to calculate patient-based benefits of CT added to ultrasound. RESULTS: Of 801 pathologically proven neck levels, ultrasound/CT showed higher sensitivities in both central and lateral compartments and improved accuracy in the lateral compartment compared to ultrasound alone...
May 13, 2018: Head & Neck
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