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mediastinal pathology

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https://www.readbyqxmd.com/read/29456861/critical-airway-compression-caused-by-a-large-mediastinal-tumour-with-spontaneous-haemorrhage
#1
Shih-Peng Liu, Hung-Che Chien, Chun-Ku Chen, Chih-Cheng Hsieh, Chien-Sheng Huang
We report the case of a 77-year-old woman presenting with out-of-hospital cardiac arrest, which was then interpreted as an acute, life-threatening critical airway compression by a huge mediastinal tumour without appropriate diagnosis. Emergency extracorporeal membrane oxygenation was cannulated for sufficient respiratory support after spontaneous circulation was regained. After the multidisciplinary team, involving thoracic surgeons, discussed the resectability of the mediastinal tumour, the patient underwent successful resection of the mediastinal tumour through a median sternotomy...
April 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29450699/consolidation-tumor-ratio-on-chest-computed-tomography-as-predictor-of-postoperative-nodal-upstaging-in-clinical-t1n0-lung-cancer
#2
Youngkyu Moon, Jae Kil Park, Kyo Young Lee, Min Namkoong, Seha Ahn
BACKGROUND: In clinical T1N0 peripheral lung cancers, lymph node upstaging is occasionally encountered postoperatively. However, nodal upstaging is rare in lung cancers presenting as ground-glass opacities. The aim of this study was to determine if lymph node upstaging could be reliably extrapolated from parameters such the consolidation/tumor ratio of chest computed tomography. METHODS: We conducted a retrospective study of 486 patients treated for peripheral clinical T1N0 non-small cell lung cancer, each undergoing lobectomy with mediastinal lymph node dissection...
February 15, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29447922/regional-lymph-node-sampling-in-lung-carcinoma-a-single-institutional-and-national-database-comparison
#3
Dustin E Bosch, Farhood Farjah, Douglas E Wood, Rodney A Schmidt
Assessing regional lymph node metastasis is a key component of lung carcinoma staging and prognostication. Recent guidelines have suggested a quality metric of 10 total regional lymph nodes sampled with each stage I-II primary lung carcinoma resection. However, the extent of mediastinal lymph node sampling remains controversial. We assessed factors contributing to regional lymph node counts and effect on overall patient survival in an institutional cohort of 888 cases and the Surveillance, Epidemiology, and End Results (SEER) national cancer registry (10 856 cases)...
February 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29445946/paravertebral-tumours-of-the-cervicothoracic-junction-extending-into-the-mediastinum-surgical-strategies-in-a-no-man-s-land
#4
Georgios K Prezerakos, Parag Sayal, Antonios Kourliouros, Periclis Pericleous, George Ladas, Adrian Casey
PURPOSE: Cervicothoracic paravertebral neoplasms extending into the mediastinum pose a surgical challenge due the complex regional anatomy, their biological nature, rarity and surgeon's unfamiliarity with the region. We aim to define a surgical access framework addressing the aforementioned complexities whilst achieving oncological clearance. METHODS: We carried out a retrospective review of 28 consecutive patients operated in two tertiary referral centres between 1998 and 2015...
February 14, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29445601/predictors-of-unexpected-nodal-upstaging-in-patients-with-ct1-3n0-non-small-cell-lung-cancer-nsclc-submitted-to-thoracoscopic-lobectomy
#5
Giuseppe Marulli, Enrico Verderi, Giovanni M Comacchio, Nicola Monaci, Giuseppe Natale, Samuele Nicotra, Federico Rea
Background: In the last decades, the use of video-assisted thoracoscopic surgery (VATS) lobectomy for the treatment of early stage non-small cell lung cancer is continuously growing. This is mainly due to the development of more advanced surgical devices, to the rising incidence of peripheral lung tumors and is also favored by the increased reliability of preoperative staging techniques. Despite this progress, postoperative unexpected nodal upstaging is still a relevant issue. Aim of this study is to identify possible predictors of unexpected nodal upstaging in patients affected by cT1-3N0 NSCLC submitted to VATS lobectomy...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29439724/lobulated-esophageal-schwannoma-resected-with-concurrent-approach-from-the-thorax-and-cervix
#6
Yoshinori Iwata, Chihiro Tanaka, Shuji Komori, Narutoshi Nagao, Masahiko Kawai, Kazuhiro Yoshida, Katsuyuki Kunieda
BACKGROUND: Esophageal schwannomas are rare esophageal submucosal tumors. We herein report a case of a lobulated esophageal schwannoma resected with concurrent approach from the thorax and cervix. CASE PRESENTATION: A 74-year-old woman visited our hospital with complaint of loss of consciousness, and a lobulated mediastinal tumor was discovered by chance in computed tomography. Upper gastrointestinal endoscopy showed a smooth elevated lesion at a position of 23-28 cm from the incisor teeth...
February 13, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29433713/pulmonologist-s-road-map-to%C3%A2-mediastinal-lymph-node%C3%A2-imaging
#7
REVIEW
Hamza Jawad, Jonathan H Chung
Mediastinal lymph node station maps are intended to facilitate nodal staging in patients with non-small cell lung cancer. These maps have been revised over time and the International Association for Study of Lung Cancer (IASLC) map is the latest rendition. This article illustrates the imaging appearance of each of the IASLC map mediastinal lymph node stations, overviews some of the mediastinal lymph node sampling techniques, and discusses common pitfalls of the IASLC map. It also reviews mediastinal anatomic variants and pathologic features that may simulate lymphadenopathy...
March 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29430426/outcomes-of-pulmonary-resection-and-mediastinal-node-dissection-by-video-assisted-thoracoscopic-surgery-following-neoadjuvant-chemoradiation-therapy-for-stage-iiia-n2-non-small-cell-lung-cancer
#8
Yeong Jeong Jeon, Yong Soo Choi, Kyung Jong Lee, Se Hoon Lee, Hongryull Pyo, Joon Young Choi
Background: We evaluated the feasibility and outcomes of pulmonary resection and mediastinal node dissection (MND) by video-assisted thoracoscopic surgery (VATS) following neoadjuvant therapy for stage IIIA N2 non-small cell lung cancer (NSCLC). Methods: From November 2009 to December 2013, a total of 35 consecutive patients with pathologically or radiologically confirmed stage IIIA N2 lung cancer underwent pulmonary resection and MND, performed by a single surgeon, following neoadjuvant chemoradiation...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29428371/survival-outcome-of-intermediate-risk-neuroblastoma-at-children-cancer-hospital-egypt
#9
Hossam Elzomor, Gehad Ahmed, Salma Elmenawi, Naglaa Elkinaai, Amal Refaat, Sonya Soliman, Mai Amr Abdelwahab, Mohamed Saad Zaghloul, Mohamed Fawzy
AIM: The study aims to evaluate survival outcome in newly diagnosed pediatric intermediate risk neuroblastoma patients treated at the Children Cancer Hospital - Egypt and their relation to various clinical and pathological factors. METHODS: The study included stage 3 patients <1.5 years, children 1.5 years or older with stage 3 disease and favorable histopathological features, infants (<1 year) with International Neuroblastoma Staging System (INSS) stage 4 disease, stage 4 children 1-1...
February 7, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29424404/-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#10
Gonzalo Labarca, Iván Caviedes, Erik Folch, Adnan Majid, Sebastián Fernández-Bussy
In the last years, several techniques have been developed to obtain a prompt diagnosis or rule out lung cancer. Endobronchial ultrasound- guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield for mediastinal and central pulmonary lesions. This procedure is especially useful for lung cancer diagnosis and mediastinal staging. Two different types of EBUS are currently available: Radial EBUS and lineal EBUS. Each one has technical differences together with a range of clinical indications...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29413057/tumor-biomarker-testing-in-non-small-cell-lung-cancer-a-decade-of-change
#11
Paul A VanderLaan, Deepa Rangachari, Adnan Majid, Mihir S Parikh, Sidharta P Gangadharan, Michael S Kent, Danielle C McDonald, Mark S Huberman, Susumu S Kobayashi, Daniel B Costa
INTRODUCTION: Although a growing list of essential genomic/immune-based biomarkers are linked to approved non-small-cell lung cancer (NSCLC) therapies worldwide, few reports have detailed the evolution of NSCLC predictive biomarker assessment in routine clinical practice. METHODS: We retrospectively reviewed the first one thousand plus NSCLC patient specimens from our institution analyzed for predictive biomarkers from 2004 to 2017 and evaluated patterns of testing as well as correlation with clinical-pathologic characteristics...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29403549/observational-analysis-on-inflammatory-reaction-to-talc-pleurodesis-small-and-large-animal-model-series-review
#12
Jacopo Vannucci, Guido Bellezza, Alberto Matricardi, Giulia Moretti, Antonello Bufalari, Lucio Cagini, Francesco Puma, Niccolò Daddi
Talc pleurodesis has been associated with pleuropulmonary damage, particularly long-term damage due to its inert nature. The present model series review aimed to assess the safety of this procedure by examining inflammatory stimulus, biocompatibility and tissue reaction following talc pleurodesis. Talc slurry was performed in rabbits: 200 mg/kg checked at postoperative day 14 (five models), 200 mg/kg checked at postoperative day 28 (five models), 40 mg/kg, checked at postoperative day 14 (five models), 40 mg/kg checked at postoperative day 28 (five models)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29399023/syndrome-of-inappropriate-antidiuretic-hormone-secretion-siadh-associated-with-mediastinal-schwannoma
#13
Shin Han Song, Gyeong Ah Sim, Seon Ha Baek, Jang Won Seo, Jung Weon Shim, Ja Ryong Koo
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of euvolemic hypo-osmotic hyponatremia. There are several etiologies of SIADH including neuroendocrine tumor, pulmonary disease, infection, trauma, and medications. Here, we report a case of SIADH associated with a schwannoma involving the mediastinum in a 75-year-old woman who presented with nausea, vomiting, and general weakness. Laboratory testing showed hypo-osmolar hyponatremia, with a serum sodium level of 102mmol/L, serum osmolality of 221mOsm/kg, urine osmolality of 382mOsm/kg, urine sodium of 55 mmol/L, and plasma antidiuretic hormone (ADH) of 4...
December 2017: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/29397827/-value-of-cd-mpo-ki-67-and-c-myc-positive-rate-in-the-pathological-tissues-and-c-myc-gene-of-patients-with-t-lbl-all-for-predicting-prognosis
#14
Yang Wu, Hong-Yan Tang, Yi-Yi Ding, Xiao-Qin Pan, Chuan-Mei Tan
OBJECTIVE: To explore the value of of CD, MPO, Ki-67, C-MYC positive rates in the pathological tissues and C-MYC gene of patients with T-LBL/ALL for predicting Prognosis. METHODS: Ninty cases of T-LBL/ALL patients in our hospital were selected and included in the T-LBL/ALL group, and 30 cases of lymphnode reactive hyperplasia were selected as control group. Immunohistochemical staining was used to detect the changes of CD, MPO, Ki-67 and C-MYC positive rate in 2 groups, and the changes of C-MYC gene were detected by fluorescence in situ hybridization...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29396329/the-dutch-national-clinical-audit-for-lung-cancer-a-tool-to-improve-clinical-practice-an-analysis-of-unforeseen-ipsilateral-mediastinal-lymph-node-involvement-in-the-dutch-lung-surgery-audit-dlsa
#15
David Jonathan Heineman, Naomi Beck, Michael Wilhelmus Wouters, Thomas Jan van Brakel, Johannes Marlene Daniels, Wilhelmina Hendrika Schreurs, Chris Dickhoff
OBJECTIVE: Optimal treatment selection for patients with non-small cell lung cancer (NSCLC) depends on the clinical stage of the disease. Particularly patients with mediastinal lymph node involvement (stage IIIA-N2) should be identified since they generally do not benefit from upfront surgery. Although the standardized preoperative use of PET-CT, EUS/EBUS and/or mediastinoscopy identifies most patients with mediastinal lymph node metastasis, a proportion of these patients is only diagnosed after surgery...
January 9, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29395417/retroperitoneal-follicular-dendritic-cell-sarcoma-in-a-young-woman-diagnosis-and-treatment-challenges
#16
Rym Bouriga, Nihed Abdessaied, Makram Hochlef, Najoua Mallat, Mohamed Mahjoub, Badereddine Sriha, Slim Ben Ahmed
INTRODUCTION: Follicular dendritic cell sarcoma (FDCS) is an uncommon tumor that usually arises in lymph nodes, especially in the cervical, mediastinal, or axillary areas, but rarely in extranodal sites. Few cases have been reported in English literature so far. The scarcity may be partially due to under-recognition of this entity. Through this case report we analyzed the difficulties of clinical and pathological diagnosis of this rare tumor with its unusual location mistaken it with gynecological cancer's iliac lymph nodes metastases...
January 6, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29394812/-a-case-of-successful-cddp-plus-cpt-11-therapy-for-recurrent-carcinomatous-lymphangiosis-occurring-during-postoperative-adjuvant-therapy-for-gastric-cancer
#17
Hiroaki Inoue, Takashi Kanazawa, Satoshi Kubota, Souichiro Miyake, Michihiro Ishida, Yasuhiro Chouda
The case involved a 67-year-old man. Type 2 gastric cancer in the body of stomach was discovered, and the patient was referred to this department, where distal gastrectomy with Roux-en-Y reconstruction was carried out. The pathological classification was pT2N2H0P0CY0M0, pStage II B, and S-1 administration was started as postoperative adjuvant therapy. After 10 months of administration, a chest computed tomography(CT)scan revealed fine nodular shadows and irregular thickening of the alveolar septa in both lungs, a finding that was judged to be carcinomatous lymphangiosis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390521/solitary-fibrous-tumor-of-the-ilium-a-case-report
#18
Xiuhong Ge, Jinsheng Liao, Ryan Justin Choo, Juncheng Yan, Jingfeng Zhang
RATIONALE: Solitary fibrous tumors (SFTs) are rare spindle cell tumors that are most commonly found in the mediastinal pleura. Although there are increasingly more reports of extra-pleural SFTs, reports of SFTs in bone are very rare. To our knowledge, a SFT of the ilium has not yet been reported. With low specificity on computer tomograpy and magnetic resonance imaging, SFTs are easily misdiagnosed. PATIENT CONCERNS: A 33-year-old man visited our hospital due to repeated right ilium pain for 3 months...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390328/foregut-duplication-cyst-a-novel-computed-tomography-finding-mimicking-a-small-bowel-hernia-a-case-report
#19
Ji Eun Choi, Soyeoun Lim, Chang Ryul Park, Hee Jeong Cha, Woon-Jung Kwon
RATIONALE: A foregut duplication cyst (FDC) is an uncommon congenital disease. This report presents a case of mediastinal foregut duplication cyst that mimicked a diaphragmatic small bowel hernia. PATIENT CONCERN: A 27-month-old girl was first referred for a mediastinal lesion found incidentally on a chest radiograph. At that time, our impression was cystic lung lesion such as congenital pulmonary airway malformation or pulmonary sequestration. At the age 6 years, she presented with recurrent vomiting...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390280/clinical-and-pathology-analysis-of-1-case-of-adult-pleural-pulmonary-blastoma-a-case-report
#20
Yi Liu, Dongbo Luo, Tongxin Du, Hongjiang Wang
RATIONALE: Pulmonary blastoma is a rare primary lung cancer that can be categorized into adult type and child type. The clinical symptoms and imaging features of pulmonary blastoma are nonspecific, making it difficult to diagnose preoperatively. Postoperative pathology with immunohistochemical staining can help diagnosis. PATIENT CONCERNS: A 53-year-old male had chest tightness and shortness of breath. DIAGNOSES: The patient was diagnosed as pleural pulmonary blastoma based on computed tomography (CT) scan, pathology, immunohistochemistry, and molecular pathology...
December 2017: Medicine (Baltimore)
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