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mediastinal pathology

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https://www.readbyqxmd.com/read/29217088/induction-cisplatin-docetaxel-followed-by-surgery-and-erlotinib-in-non-small-cell-lung-cancer
#1
Tina Cascone, Kathryn A Gold, Stephen G Swisher, Diane D Liu, Frank V Fossella, Boris Sepesi, Apar Pataer, Annikka Weissferdt, Neda Kalhor, Ara A Vaporciyan, Wayne L Hofstetter, Ignacio I Wistuba, John V Heymach, Edward S Kim, William N William
BACKGROUND: Data from meta-analyses support the use of induction or adjuvant platinum-based chemotherapy for locally advanced non-small cell lung cancers (NSCLCs). This phase 2 study assessed the role of induction cisplatin and docetaxel followed by surgery in patients with resectable stage I to III NSCLCs, followed by 12 months of adjuvant erlotinib. METHODS: Patients with resectable stage I to III NSCLCs received cisplatin 80 mg/m2, docetaxel 75 mg/m2 every 21 days for 3 cycles, followed by surgery, followed by adjuvant erlotinib for 12 months...
December 4, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29201483/purulent-appearing-material-in-an-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-mediastinal-lymph-node-a-diagnostic-challenge
#2
Damaris Pena, Gilda Diaz-Fuentes, Sindhaghatta Venkatram
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has increasingly been performed for the diagnosis and staging of thoracic malignancies. Findings of a necrotic lymph node raise concern for infectious process and malignancy. A hypoechoic area on ultrasound/EBUS within a lymph node without blood flow is suggestive of pathologies like infections or malignancy. Inspection of the fluid could suggest a diagnosis; clear aspirates usually suggest bronchogenic or mediastinal cysts and purulent material suggests abscesses or necrotic lymph nodes...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29200670/clinico-radiological-and-pathological-characteristics-of-inflammatory-myofibroblastic-tumors-in-children-a-retrospective-study
#3
Mohamad Hussain Mir, Waseem Dar, Sheikh Aejaz Aziz, Gul Mohamad, Burhan Wani
Purpose: Inflammatory myofibroblastic tumors (IMTs) are rare, benign lesions most often seen in the lung of young adults but can occur in children, in various sites. They mimic, clinically and radiologically, malignant tumors - especially sarcomas and lymphomas. The aim was to review the clinical, radiological, and pathological data of children with a diagnosis of IMT referred to our department. Materials and Methods: This retrospective study was conducted at the Department of Medical and Paediatric Oncology, Regional Cancer Centre, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India from January 2014 to December 2015...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29196627/pathologic-n0-status-in-clinical-t1n0m0-lung-adenocarcinoma-is-predictable-by-the-solid-component-proportion-with-quantitative-ct-number-analysis
#4
Meng Li, Ning Wu, Li Zhang, Wei Sun, Jianwei Wang, Lv Lv, Jiansong Ren, Dongmei Lin
Correctly predicting pathologic regional node-negative (pN0) disease in patients with lung cancer before operation may avoid unnecessary mediastinal lymph node dissection (MLND). In this study, we analyze the value of the radiographic and histopathological features of primary tumors for predicting pN0 status in cT1N0M0 lung adenocarcinoma and to establish an optimal surgical strategy for avoiding MLND in cT1N0M0 lung adenocarcinoma patients. We retrospectively investigated the histopathological and radiographic data of 348 surgically resected cT1N0M0 lung adenocarcinoma patients with systematic lymph node dissection from January 2005 to December 2012...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29194832/the-pathogenesis-of-paraesophageal-empyema-in-dogs-and-constancy-of-radiographic-and-computed-tomography-signs-are-linked-to-involvement-of-the-mediastinal-serous-cavity
#5
Karine Gendron, Sean P McDonough, James A Flanders, May Tse, Peter V Scrivani
The mediastinal serous cavity is a normal anatomic space in the caudal mediastinum. Aims of this anatomic and case series study were to describe the signs of pathologic expansion of the mediastinal serous cavity observed during computed tomography (CT), review the underlying anatomy, perform a literature review, and evaluate the medical records of several dogs with mediastinal serous cavity empyema (paraesophageal empyema). The mesothelial lined mediastinal serous cavity is a cranial extension of the omental bursa, separated from the peritoneal cavity by the diaphragm, in the dorsal part of the caudal mediastinum, to the right of the esophagus, between the heart base and diaphragm...
November 30, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29191583/wolf-in-sheep-s-clothing-primary-lung-cancer-mimicking-benign-entities
#6
REVIEW
Annemie Snoeckx, Amélie Dendooven, Laurens Carp, Damien Desbuquoit, Maarten J Spinhoven, Patrick Lauwers, Paul E Van Schil, Jan P van Meerbeeck, Paul M Parizel
Lung cancer is the most common cancer worldwide. On imaging, it typically presents as mass or nodule. Recognition of these typical cases is often straightforward, whereas diagnosis of uncommon manifestations of primary lung cancer is far more challenging. Lung cancer can mimic a variety of benign entities, including pneumonia, lung abscess, postinfectious scarring, atelectasis, a mediastinal mass, emphysema and granulomatous diseases. Correlation with previous history, clinical and biochemical parameters is necessary in the assessment of these cases, but often aspecific and inconclusive...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29187154/thymoma-with-acute-gastric-volvulus-a-case-report
#7
Ailing Liu, Xin Gao, Lin Zhao
BACKGROUND: Acute gastric volvulus (GV) is a rare disease with high mortality rate often associated with anatomic abnormalities. Thymoma is the most common neoplasm located in the anterior mediastinum. There is no reported relationship between thymoma and GV. Here we reported a case of thymoma with initial symptom of acute gastric volvulus. CASE PRESENTATION: A 43-year-old man complained of postprandial abdominal pain, nausea and vomiting. Acute gastric volvulus was diagnosed by chest radiograph, upper digestive tract radiograph and CT scan; later type B3 thymoma was diagnosed by biopsy of mediastinal mass...
November 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29181268/the-flip-flop-fungus-sign-an-fdg-pet-ct-sign-of-benignity
#8
Alex A Nagelschneider, Stephen M Broski, William P Holland, David E Midthun, Anne-Marie Sykes, Val J Lowe, Patrick J Peller, Geoffrey B Johnson
Benign granulomatous processes such as fungal infection may mimic metastatic lung cancer on FDG PET/CT. We found that these processes often have draining lymph node(s) with equal or greater FDG activity than associated lung nodule(s), a "flip-flop" of what is commonly seen in lung cancer. The aim of this study was to examine the utility of this "flip-flop fungus" (FFF) sign for diagnosing benign pulmonary disease. FDG PET/CT scans performed between 9/09-3/13 for the indications of pulmonary nodule or mass were reviewed...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29179511/the-role-of-endobronchial-ultrasound-elastography-in-the-diagnosis-of-mediastinal-and-hilar-lymph-nodes
#9
Ye Gu, Hong Shi, Chunxia Su, Xiaoxia Chen, Shijia Zhang, Wei Li, Fengying Wu, Guanghui Gao, Hao Wang, Haiqing Chu, Caicun Zhou, Fei Zhou, Shengxiang Ren
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been widely used for diagnosis and mediastinal lymph nodes staging in patients with suspicious lung cancer. Ultrasound elastography is a novel sonographical technique that can evaluate tissue compressibility. The aim of the present study was to investigate the diagnostic yield of elastography for differentiating malignant and benign mediastinal lymph nodes. Conventional EBUS B-mode features, including size, shape, border distinction, echogenicity, central hilar structure with central blood vessel and coagulation necrosis were also evaluated...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29173765/esophageal-ultrasound-eus-assessment-of-t4-status-in-nsclc-patients
#10
Jolanda C Kuijvenhoven, Laurence Crombag, David P Breen, Inge van den Berk, Michel I M Versteegh, Jerry Braun, Toon A Winkelman, Wimjan van Boven, Peter I Bonta, Klaus F Rabe, Jouke T Annema
BACKGROUND: Mediastinal and central large vessels (T4) invasion by lung cancer is often difficult to assess preoperatively due to the limited accuracy of computed tomography (CT) scan of the chest. Esophageal ultrasound (EUS) can visualize the relationship of para-esophageally located lung tumors to surrounding mediastinal structures. AIM: To assess the value of EUS for detecting mediastinal invasion (T4) of centrally located lung tumors. METHODS: Patients who underwent EUS for the diagnosis and staging of lung cancer and in whom the primary tumor was detected by EUS and who subsequently underwent surgical- pathological staging (2000-2016) were retrospectively selected from two university hospitals in The Netherlands...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29154082/are-preoperative-sestamibi-scans-useful-for-identifying-ectopic-parathyroid-glands-in-patients-with-expected-multigland-parathyroid-disease
#11
Farah Karipineni, Zeyad Sahli, Helina Somervell, Aarti Mathur, Jason D Prescott, Ralph P Tufano, Martha A Zeiger
BACKGROUND: The role of preoperative localization studies in patients with hyperparathyroidism and expected multigland disease remains poorly defined. Our study investigates the usefulness of obtaining preoperative sestamibi scans and ultrasonography of the neck in identifying ectopic glands in this group of patients. METHODS: Under Institutional Review Board approval, we performed a retrospective review of patients who underwent operation for secondary hyperparathyroidism, tertiary hyperparathyroidism, lithium-induced hyperparathyroidism, and multiple endocrine neoplasia syndrome at a tertiary institution between 2004 and 2015...
November 16, 2017: Surgery
https://www.readbyqxmd.com/read/29151508/cardiac-sarcoidosis-presenting-as-acute-progressive-heart-failure-with-abdominal-lymphadenopathy
#12
Satoshi Oka, Ken Umetani, Tomoko Harama, Takuya Shimizu, Aritaka Makino, Keita Sano, Masahiko Nakamura
A 77-year-old Japanese woman presented with asymptomatic abdominal lymphadenopathy. Soluble interleukin-2 receptor (sIL2R) and angiotensin-converting enzyme (ACE) levels were elevated, and a pathological examination of lymph-node biopsies revealed non-caseating granulomas, which was consistent with sarcoidosis. Fluorodeoxyglucose-positron emission tomography did not show a clear accumulation in the mediastinal lymph-nodes or heart. Five months later, she presented with acute progressive heart failure that was refractory to conventional treatment...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29147774/assessment-of-mediastinal-lymph-node-size-in-pneumococcal-pneumonia-with-bacteremia
#13
Amit Chopra, Aakash Modi, Haroon Chaudhry, Recai Yucel, Neha Rane, John Fantauzzi, Frederic J Hellwitz, Marc A Judson
INTRODUCTION: The significance of mediastinal lymphadenopathy in bacterial pneumonia is unclear. METHODS: We performed a retrospective analysis of mediastinal lymph node size determined by chest CT in patients with bacteremic pneumococcal pneumonia. All patients who had positive blood cultures for streptococcus pneumonia over an 11-year period and had a chest CT scan (index CT) within 2 weeks of the positive blood culture were included in the study. Two thoracic radiologists and one pulmonologist independently examined the index CT plus any chest CT scans performed prior (pre-CT) or after (post-CT) the bacteremic episode...
November 16, 2017: Lung
https://www.readbyqxmd.com/read/29146413/ct-fluoroscopy-guided-core-needle-biopsy-of-anterior-mediastinal-masses
#14
T Iguchi, T Hiraki, Y Matsui, H Fujiwara, J Sakurai, Y Masaoka, M Uka, T Tanaka, H Gobara, S Kanazawa
OBJECTIVE: To retrospectively evaluate the safety, diagnostic yield, and risk factors of diagnostic failure of computed tomography (CT) fluoroscopy-guided biopsies of anterior mediastinal masses. MATERIALS AND METHODS: Biopsy procedures and results of anterior mediastinal masses in 71 patients (32 women/39 men; mean [±standard deviation] age, 53.8±20.0years; range, 14-88years) were analyzed. Final diagnoses were based on surgical outcomes, imaging findings, or clinical follow-up findings...
November 13, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29137875/contribution-of-11-c-choline-pet-ct-in-prostate-carcinoma-biochemical-relapse-with-serum-psa-level-below-1-ng-ml
#15
F J Gómez-de la Fuente, I Martínez-Rodríguez, M de Arcocha-Torres, R Quirce, J Jiménez-Bonilla, N Martínez-Amador, I Banzo
OBJECTIVE: (11)C-choline PET/CT has demonstrated good results in the restaging of prostate cancer (PCa) with high serum prostate specific antigen (PSA), but its use in patients with low serum PSA is controversial. Our aim was to evaluate the contribution of (11)C-choline PET/CT in patients with PCa, biochemical relapse and PSA <1 ng/ml. MATERIAL AND METHOD: Fifty consecutive patients (mean age: 65.9±5.6 years) with biochemical relapse of PCa and serum PSA <1ng/ml were evaluated retrospectively...
November 11, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29136038/midterm-outcomes-of-single-port-thoracoscopic-surgery-for-major-pulmonary-resection
#16
Kook Nam Han, Hyun Koo Kim, Young Ho Choi
INTRODUCTION: Single-port thoracoscopic surgery has widened the current minimally invasive surgical techniques toward more less invasive procedures in terms of reducing the number of incisions. However, the current status of oncologic outcome with this technique is not well known for lung cancer surgery. The purpose of this study is to evaluate the oncologic outcomes in early stage lung cancer for impact of the survival outcomes with our experience of conversion to a single-port approach from the conventional three-port approach...
2017: PloS One
https://www.readbyqxmd.com/read/29127917/a-giant-mediastinal-liposarcoma-weighing-3500g-resected-with-clam-shell-approach-a-case-report-with-review-of-literature
#17
Yasoo Sugiura, Toshinori Hashizume, Hiroyuki Fujimoto, Etsuo Nemoto
INTRODUCTION: Liposarcoma is rare in the mediastinum and is less than 1% of all mediastinal tumors. In the present report, we demonstrated our case and summarized the principal treatment of the mediastinal liposarcoma with literature review. PRESENTATION OF CASE: A 50-year-old man presented at our hospital with complain of dyspnea. Chest radiography showed remarkable cardiomegaly. Computed tomography revealed an anterior mediastinal tumor from the level of the cephalic vein to the diaphragm of bilateral thoracic cavity with fat component...
November 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29127250/malignant-peripheral-nerve-sheath-tumours-of-the-pericardium-in-a-patient-with-neurofibromatosis-type-1-the-diagnostic-value-of-18f-fdg-pet-ct-and-i-123-mibg-spect-ct
#18
Mathieu Charest, Josephine Pressacco, Jaramie Thomas-Gittens
A 25 year old female with known neurofibromatosis type 1 with a large anterior mediastinal mass was investigated. F18-FDG PET-CT revealed a radiotracer avid anterior mediastinal mass with SUVmax of 4.3 and demonstrating a hypoactive center. The Iodine-123 MIBG SPECT-CT study performed subsequently did not demonstrate any uptake, thereby excluding for the most part the diagnoses of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumour (MPNST) of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29125330/benign-and-malignant-enlarged-chest-nodes-staging-by-diffusion-weighted-mri-an-alternative-to-mediastinoscopy
#19
Monica Sigovan, Pia Akl, Caroline Mesmann, Francois Tronc, Salim Si Mohamed, Philippe Douek, Loic Boussel
OBJECTIVE: To evaluate the accuracy of diffusion weighted MRI with background suppression (DWIBS) in differentiating between malignant and benign mediastinal lymph-nodes. METHODS: Consecutive patients with enlarged mediastinal lymph-nodes underwent MRI DWIBS within 10 days prior to mediastinoscopy. Relative contrast ratios (RCR) were computed on b800 and apparent diffusion coefficient (ADC) maps by dividing the node signal with the chest muscle signal, using manually drawn regions of interest (ROIs) by radiologists, blinded to pathology...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29122557/-maternal-deaths-due-to-anesthesia-complications-results-from-the-french-confidential-enquiry-into-maternal-deaths-2010-2012
#20
D Chassard
Over the period 2010-2012, maternal mortality linked to anesthesia accounted for 2% of maternal deaths, with no significant change since 2007-2009. Of the 7 maternal deaths analyzed by the expert committee, anesthetic complications were in 5 cases the main cause of death: 4 attributed to direct causes related to anesthetic procedures during childbirth and 1 to indirect cause in connection with an ENT complication during pregnancy. The anesthetic causes of maternal mortality were for the 2010-2012 period: cardiac arrest under spinal anesthesia during caesarean section, local anesthetic intoxication with unsuccessful resuscitation after cardiac arrest without intralipid administration, acute respiratory distress syndrome in the postpartum period after pulmonary aspiration during caesarean section, cardiac arrest during caesarean section under general anesthesia in a context of non-Hodgkin lymphoma with mediastinal syndrome, unsuccessful endotracheal intubation in a context of cellulitis of the oral cavity floor...
November 6, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
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