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https://www.readbyqxmd.com/read/29033676/the-role-of-fluorodeoxy-d-glucose-positron-emission-tomography-computed-tomography-in-nodal-staging-of-nonsmall-cell-lung-cancer-in-sequential-surgical-algorithm
#1
Yuyang Zhang, Yolanda Elam, Patricia Hall, Hadyn Williams, Darko Pucar, Vijay Patel
With nonsmall cell lung cancer (NSCLC), accurate mediastinal nodal staging is crucial to determine whether a patient is or is not a surgical candidate. Traditionally, computed tomography (CT) and fluorodeoxy-D-glucose (FDG) positron emission tomography (PET)/CT are the initial steps followed by tissue sampling through mediastinoscopy and/or thoracotomy, which are invasive procedures. There is controversy regarding the possibility of omission of the invasive diagnostic procedures and solely relying on noninvasive presurgical staging CT and FDG PET/CT results...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033013/clinical-prognosis-of-superior-versus-basal-segment-stage-i-non-small-cell-lung%C3%A2-cancer
#2
Yoshinori Handa, Yasuhiro Tsutani, Norifumi Tsubokawa, Keizo Misumi, Hideaki Hanaki, Yoshihiro Miyata, Morihito Okada
BACKGROUND: Despite its extensive size, variations in the clinicopathologic features of tumors in the lower lobe have been little studied. The present study investigated the prognostic differences in tumors originating from the superior and basal segments of the lower lobe in patients with non-small cell lung cancer. METHODS: Data of 134 patients who underwent lobectomy or segmentectomy with systematic nodal dissection for clinical stage I, radiologically solid-dominant, non-small cell lung cancer in the superior segment (n = 60) or basal segment (n = 74) between April 2007 and December 2015 were retrospectively reviewed...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29029632/fatal-haemorrhage-and-neoplastic-thrombosis-in-a-captive-african-lion-panthera-leo-with-metastatic-testicular-sex-cord-stromal-tumour
#3
Omar Antonio Gonzales-Viera, Angélica María Sánchez-Sarmiento, Natália Coelho Couto de Azevedo Fernandes, Juliana Mariotti Guerra, Rodrigo Albergaria Ressio, José Luiz Catão-Dias
BACKGROUND: The study of neoplasia in wildlife species contributes to the understanding of cancer biology, management practices, and comparative pathology. Higher frequencies of neoplasms among captive non-domestic felids have been reported most commonly in aging individuals. However, testicular tumours have rarely been reported. This report describes a metastatic testicular sex cord-stromal tumour leading to fatal haemorrhage and thrombosis in a captive African lion (Panthera leo). CASE PRESENTATION: During necropsy of a 16-year-old male African lion, the left testicle and spermatic cord were found to be intra-abdominal (cryptorchid), semi-hard and grossly enlarged with multiple pale-yellow masses...
October 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29021485/spontaneous-regression-of-epithelioid-angiosarcoma-in-a-young-woman
#4
Suya Hori, Motoko Tachihara, Daisuke Tamura, Kazuyuki Kobayashi, Kyosuke Nakata, Hiroshi Kamiryo, Yasuhiro Sakai, Tomoo Itoh, Takanori Hirose, Yoshihiro Nishimura
A 20-year-old Japanese woman with a history of pulmonary atresia was referred to our hospital after the detection of an abnormal mass in the right lung and mediastinal lymphadenopathy. A cytological specimen obtained by transbronchial brushing indicated that the pathological diagnosis was non-small cell lung cancer. During the follow-up period, the tumor spontaneously regressed. At four months after the diagnosis, she experienced sudden bleeding from the small intestine. The histological characteristics of the small intestine tumor were compatible with the cytological characteristics of the lung tumor...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#5
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28973110/association-of-pathologic-nodal-staging-quality-with-survival-among-patients-with-non-small-cell-lung-cancer-after-resection-with-curative-intent
#6
Matthew P Smeltzer, Nicholas R Faris, Meredith A Ray, Raymond U Osarogiagbon
Importance: Pathologic nodal stage is the most significant prognostic factor in resectable non-small cell lung cancer (NSCLC). The International Association for the Study of Lung Cancer NSCLC staging project revealed intercontinental differences in N category-stratified survival. These differences may indicate differences not only in cancer biology but also in the thoroughness of the nodal examination. Objective: To determine whether survival was affected by sequentially more stringent definitions of pN staging quality in a cohort of patients with NSCLC after resection with curative intent...
September 28, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28962510/a-rare-case-of-left-innominate-vein-aneurysm-mimicking-thymoma
#7
Wei Huang, Ge Ning Jiang
Thoracic venous aneurysms are very rare conditions, even more unusual from left innominate vein. We report a case of a 57-year-old male who presented an anterior mediastinal mass suspicious of thymoma by chest computed tomography. Median sternotomy was performed aiming for total thymectomy, but intraoperative findings and final pathology confirmed the diagnosis of left innominate vein aneurysm. The patient underwent aneurysmectomy and reconstruction of the left innominate vein. The patient remains well 2 years after surgery...
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28958031/pathological-lymph-node-involvement-is-not-a-predictor-of-adverse-outcomes-in-patients-undergoing-thoracoscopic-lobectomy-for-lung-cancer
#8
Udo Abah, Gianluca Casali, Timothy James Peacock Batchelor, Eveline Internullo, Rakesh Krishnadas, Natasha Joshi, Samson Egbulonu, Frances Warden, Vito Domenico Bruno, Douglas George West
OBJECTIVES: As the practice of video-assisted thoracoscopic surgery (VATS) lobectomy gains widespread acceptance, the complexity of procedures attempted increases and the stage of tumour that may be safely approached remains controversial. We examined the impact of nodal involvement with respect to perioperative outcomes after VATS lobectomy. METHODS: All patients listed for VATS lobectomy for non-small-cell lung cancer at our institution from 2012 to 2016 were analysed...
August 29, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28957889/conventional-transbronchial-needle-aspiration-the-original-guard-who-still-has-a-role-in-mediastinal-lymph-node-sampling
#9
Ravindra M Mehta, Abhinav Singla, Arjun Lakshmana Balaji, Shantha Krishnamurthy, Rajani S Bhat, Chakravarthi Lokanath
INTRODUCTION: Conventional transbronchial needle aspiration (C-TBNA) is the originally described method for sampling mediastinal lymph nodes (MLN). After the advent of endobronchial ultrasound, the practice and reports of C-TBNA have dwindled. We report a large series of C-TBNA from the Indian subcontinent, highlighting aspects such as pathological spectrum, yield and complications, and reiterating its relevance in MLN sampling. METHODS: The study population included 400 consecutive patients over 6...
October 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28955119/magnetic-resonance-lymphangiography-and-lymphatic-embolization-in-the-treatment-of-pulmonary-complication-of-lymphatic-malformation
#10
REVIEW
Maxim Itkin
Lymphatic malformations (LMs; especially those involving the central conducting lymphatic channels) are characterized by dysplastic and incompetent lymphatic channels in multiple tissues and organs. The major cause of mortality and morbidity in patients with thoracic LM is deterioration of pulmonary function due to chronic chylous effusions and progressive interstitial lung disease. The etiology of these pulmonary processes is unknown, although lymphatic involvement is certain. Understanding of the changes in the lymphatic anatomy in patients with LM has been hindered by difficulty of imaging of the lymphatic system...
September 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28954036/yolk-sac-primary-tumor-of-mediastino-a-rare-case-in-a-young-adult
#11
Lorena Luryann Cartaxo da Silva, Fernanda Sasaki Vergilio, Diva Carvalho Collarile Yamaguti, Isabela Azevedo Nicodemos da Cruz, Joana Angrisani Granato Queen
Germ cell tumors are rare neoplasms that mostly occur in the gonads, although they can also affect other body sites, especially the anterior mediastinum (50 to 70% of all extragonadal germ cell tumors). We report a case of a primary mediastinal yolk sac tumor, a rare and aggressive germ cell tumors subtype. This was a 38-year-old man who was admitted to Hospital do Servidor Público Estadual "Francisco Morato de Oliveira", complaining about dyspnea and dry cough for 1 year. The computed tomography scan of his chest revealed a large mass in the anterior mediastinum with heterogeneous enhancement to the contrast associated with pleural effusion...
September 21, 2017: Einstein
https://www.readbyqxmd.com/read/28950357/novel-perspective-to-evaluate-the-safety-of-segmentectomy-clinical-significance-of-lobar-and-segmental-lymph-node-metastasis-in-ct1n0m0-lung-adenocarcinoma
#12
Fei Xiao, Qiduo Yu, Zhenrong Zhang, Deruo Liu, Yongqing Guo, Chaoyang Liang, Bei Wang, Hongliang Sun
OBJECTIVES: The regularity of intrapulmonary lobar and segmental lymph node (LSN) metastasis in cT1N0M0 stage lung adenocarcinoma remains unclear. Thus, segmentectomy with uncertain LSN metastatic status remains a potential oncological risk. We aimed to facilitate more accurate determination of N staging and filter more suitable cases for segmentectomy. METHODS: A prospective study was performed from March 2014 to September 2016. A total of 196 patients diagnosed with cT1N0M0 stage lung adenocarcinoma were enrolled and received lobectomy together with mediastinal lymph node dissection...
July 4, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28950348/report-from-the-european-society-of-thoracic-surgeons-database-2017-patterns-of-care-and-perioperative-outcomes-of-surgery-for-malignant-lung-neoplasm
#13
Michele Salati, Alessandro Brunelli, Herbert Decaluwe, Zalan Szanto, Marcel Dahan, Gonzalo Varela, Pierre-Emmanuel Falcoz
OBJECTIVES: The European Society of Thoracic Surgeons (ESTS) registry was created 10 years ago and represents an international database collecting thoracic surgery procedures from European contributors. The purpose of the present report was to offer an overview of baseline and surgical characteristics and outcomes of patients submitted to lung resections for malignant lung disease as derived from the ESTS registry. METHODS: We retrieved data about all lung resections from 2007 to 2016 performed for primary and metastatic (secondary) lung cancer...
July 31, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28942077/transcervical-extended-mediastinal-lymphadenectomy-experience-from-a-north-american-cancer-center
#14
Sai Yendamuri, Athar Battoo, Grace Dy, Hongbin Chen, Jorge Gomez, Anurag K Singh, Mark Hennon, Chukwumere E Nwogu, Elisabeth U Dexter, Miriam Huang, Anthony Picone, Todd L Demmy
BACKGROUND: Accurate staging of the mediastinum is a critical element of therapeutic decision making in non-small cell lung cancer. We sought to determine the utility of transcervical extended mediastinal lymphadenectomy (TEMLA) in staging non-small cell lung cancer for large central tumors and after induction therapy. METHODS: A retrospective record review was performed of all patients who underwent TEMLA at our institution from 2010 to 2015. Clinical stage as assessed by positron emission tomography integrated with computed tomography (PET-CT), stage as assessed by TEMLA, final pathologic stage, lymph node yield, and clinical characteristics of tumors were assessed along with TEMLA-related perioperative morbidity...
September 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28932400/mediastinal-peripheral-t-cell-lymphoma-diagnosed-by-repeated-biopsies-after-an-initial-diagnosis-of-fibrosing-mediastinitis
#15
Naoko Kakuta, Mitsuhiro Sumitani, Arata Sugitani, Kenji Nakahama, Yuzo Miki, Seichi Syoji
We report a case of mediastinal peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) diagnosed by repeated biopsies. A 44-year-old man was admitted to our hospital with a 2-week history of facial swelling, neck distension, and dyspnoea on exertion. Computed tomography of the chest showed a mediastinal mass. Initial needle biopsy and video-assisted thoracoscopic biopsy revealed the pathological diagnosis of fibrosing mediastinitis (FM). Glucocorticoid therapy (prednisolone) was temporarily effective in reducing tumour size...
November 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28929210/discrimination-of-malignant-versus-benign-mediastinal-lymph-nodes-using-diffusion-mri-with-an-ivim-model
#16
Li-Ping Qi, Wan-Pu Yan, Ke-Neng Chen, Zheng Zhong, Xiao-Ting Li, Kejia Cai, Ying-Shi Sun, Xiaohong Joe Zhou
OBJECTIVES: To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN). METHODS: Thirty-five subjects with enlarged MLN were scanned at 1.5 Tesla. Diffusion-weighted imaging was performed with eight b-values. IVIM parameters D, D*, and f, as well as apparent diffusion coefficient (ADC) from a mono-exponential model were obtained. 91 nodes (49 malignant and 42 benign) were analysed with pathologic (n=90) or radiologic (n=1) confirmations...
September 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28904677/-pulmonary-nocardiosis-in-immunocompetent-patients-about-2-cases
#17
Yasmina Rhofir, Rachida Zahraoui, Nabil Tiress, Hicham Naji-Amrani, Mouna Soualhi, Jamal Eddine Bourkadi
Nocardiosis is a rare but severe infection caused by bacteria of the genus nocardia, which belong to the order actinomycetales. If they can affect immunocompetent adult, nocardioses are pathologies affecting the individuals with weakened immune system. Pulmonary involvement is the most common manifestation, its correct management is based on diagnosis, which is often delayed due to non-specific symptoms and inconclusive specimens. We here report two cases of nocardiosis in immunocompetent patients. The first case concerns a 24-year old man with a history of smoking and alcoholism, hospitalized for chest pain and hemoptysis of low abundance evolving for two months, associated with the occurrence of dorsal subcutaneous fistulized abscess...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904244/tracheobronchopathia-osteochondroplastica-in-recurrent-retrosternal-goiter-surgical-management
#18
Francesco Quaglino, Enrico Mazza, Mauro Navarra, Nicola Palestini, Valentina Marchese, Riccardo Lemini, Francesca Talarico, Emilpaolo Manno
Tracheobronchopathia osteochondroplastica (TPO) is a rare pathology characterized by a progressive segmentary stenosis of the respiratory tract due to proliferation of osteocartilagineous nodules in the lumen of the distal part of the trachea and large bronchial trunks. Prognosis is usually benign, but some cases with an acute progression and a lethal outcome have been described. Clinical presentation is non specific, the chest x-ray is generally normal and there are not typical radiological signs of suspicion: diagnosis of TPO is usually incidental...
September 4, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28898881/performance-of-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-the-diagnosis-of-isolated-mediastinal-and-hilar-lymphadenopathy
#19
Chung-Chun Tyan, Tiago Machuca, Kasia Czarnecka, Hyang Mi Ko, Gilda da Cunha Santos, Scott L Boerner, Andrew Pierre, Marcelo Cypel, Tom Waddell, Gail Darling, Marc de Perrot, Shaf Keshavjee, William Geddie, Kazuhiro Yasufuku
BACKGROUND: Although many studies have assessed the diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the context of a specific disease, few studies have assessed the overall diagnostic yield, sensitivity, and negative predictive value in patients with isolated mediastinal and hilar lymphadenopathy (IMHL). OBJECTIVE: We evaluated the performance of EBUS-TBNA for diagnosing IMHL in a population with a high prevalence of concurrent or preexisting non-pulmonary malignancy...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28894059/-re-operation-for-saccular-aneurysm-after-ascending-aortic-replacement-with-homograft-report-of-a-case
#20
Masahiro Ikeda, Toshihisa Asakura, Kazuhiko Uwabe, Kozo Morita, Atsushi Iguchi, Hiroshi Niinami
A 62-years-old female had undergone ascending aortic replacement with homograft for graft infection and mediastinitis after initial replacement of ascending aorta due to acute type A dissection. Ten years after homograft replacement, follow up computed tomography showed acute growing saccular aneurysm of the homograft without infectious symptoms. We urgently performed Bentall procedure and hemiarch replacement successfully. Pathological diagnosis was true aneurysm of the homograft. She was discharged from hospital without any complication and has been quite uneventful 7 years after surgery...
September 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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