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https://www.readbyqxmd.com/read/29675622/rheumatoid-arthritis-in-the-indigenous-qom-population-of-rosario-argentina-aggressive-and-disabling-disease-with-inadequate-adherence-to-treatment-in-a-community-based-cohort-study
#1
Rosana Quintana, Mario Goñi, Nora Mathern, Marisa Jorfen, Silvana Conti, Romina Nieto, Alvaro Sanabria, Cristina Prigione, Adriana M R Silvestre, Vanina García, Guillermo Pons-Estel, Ricard Cervera, Conrado García, Ingris Peláez-Ballestas, Graciela S Alarcón, Bernardo A Pons-Estel
To describe the baseline and follow up epidemiological/clinical characteristics of rheumatoid arthritis (RA) in a community-based cohort of the qom population. RA (ACR criteria) patients identified (n = 40) or not (n = 25) in the previous study were included. Baseline and follow-up visits (3, 6, and 12 months) were performed. Treatment adherence and modification, disability (Health Assessment Questionnaire Disability Index-HAQ-DI), and Disease Activity [DAS-28 (ESR)] were ascertained. At 12 months, complete and incomplete lost to follow-up patients were identified...
April 19, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29669399/the-impact-of-systemic-lupus-erythematosus-on-the-clinical-phenotype-of-antiphospholipid-antibody-positive-patients-results-from-antiphospholipid-syndrome-alliance-for-clinical-trials-and-international-networking-aps-action-clinical-database-and-repository
#2
Ozan Unlu, Doruk Erkan, Medha Barbhaiya, Danieli Andrade, Iana Nascimento, Renata Rosa, Alessandra Banzato, Vittorio Pengo, Amaia Ugarte, Maria Gerosa, Lanlan Ji, Maria Efthymiou, D Ware Branch, Guilherme Raires de Jesus, Angela Tincani, H Michael Belmont, Paul R Fortin, Michelle Petri, Esther Rodriguez, Guillermo J Pons-Estel, Jason S Knight, Tatsuya Atsumi, Rohan Willis, Stephane Zuily, Maria G Tektonidou
OBJECTIVE: Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist on the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with or without SLE. METHODS: A secure web-based data capture system stores patient demographics, and aPL-related clinical and laboratory characteristics...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29666118/a-simplified-scoring-system-in-de-novo-follicular-lymphoma-treated-initially-with-immunochemotherapy
#3
Emmanuel Bachy, Matthew J Maurer, Thomas M Habermann, Bénédicte Gelas-Dore, Delphine Maucort-Boulch, Jane A Estell, Eric Van den Neste, Réda Bouabdallah, Emmanuel Gyan, Andrew L Feldman, Joan Bargay, Alain Delmer, Susan L Slager, Maria Gomes da Silva, Olivier Fitoussi, David Belada, Hervé Maisonneuve, Tanin Intragumtornchai, Stephen M Ansell, Thierry Lamy, Peggy Dartigues, Brian K Link, John F Seymour, James R Cerhan, Gilles Salles
In follicular lymphoma (FL), no prognostic index has been built based solely on a cohort of patients treated with initial immunochemotherapy. There is currently a need to define parsimonious clinical models for trial stratification and to add on biomolecular factors. Here, we confirmed the validity of both the FLIPI and the FLIPI2 in the large prospective PRIMA trial cohort of 1,135 patients treated with initial R-chemotherapy +/- R maintenance. Furthermore, we developed a new prognostic tool comprising only 2 simple parameters (bone marrow involvement and β2-microglobulin (β2m)) to predict progression-free survival (PFS)...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29656435/a-multi-omic-study-reveals-btg2-as-a-reliable-prognostic-marker-for-early-stage-non-small-cell-lung-cancer
#4
Sipeng Shen, Ruyang Zhang, Yichen Guo, Elizabeth Loehrer, Yongyue Wei, Ying Zhu, Qianyu Yuan, Sebastian Moran, Thomas Fleischer, Maria Moksnes Bjaanaes, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, Li Su, Feng Chen, David C Christiani
B-cell translocation gene 2 (BTG2) is a tumor suppressor protein and is known to be downregulated in several types of cancer. In this study, we investigated a potential role for BTG2 in early-stage non-small cell lung cancer (NSCLC) survival. We analysed BTG2 methylation data from 1,230 early-stage NSCLC patients from five international cohorts, as well as gene expression data from 3,038 lung cancer cases from multiple cohorts. Three CpG probes (cg01798157, cg06373167, cg23371584) that detected BTG2 hypermethylation in tumor tissues were associated with lower overall survival...
April 15, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29653249/directing-neuronal-cell-fate-in-vitro-achievements-and-challenges
#5
REVIEW
R J M Riemens, D L van den Hove, M Esteller, R Delgado-Morales
Human pluripotent stem cell (PSC) technology and direct somatic cell reprogramming have opened up a promising new avenue in the field of neuroscience. These recent advances allow researchers to obtain virtually any cell type found in the human brain, making it possible to produce and study functional neurons in laboratory conditions for both scientific and medical purposes. Although distinct approaches have shown to be successful in directing neuronal cell fate in vitro, their refinement and optimization, as well as the search for alternative approaches, remains necessary to help realize the full potential of the eventually derived neuronal populations...
April 10, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29619118/epigenetic-modifications-in-kdm-lysine-demethylases-associate-with-survival-of-early-stage-nsclc
#6
Yongyue Wei, Junya Liang, Ruyang Zhang, Yichen Guo, Sipeng Shen, Li Su, Xihong Lin, Sebastian Moran, Åslaug Helland, Maria M Bjaanæs, Anna Karlsson, Maria Planck, Manel Esteller, Thomas Fleischer, Johan Staaf, Yang Zhao, Feng Chen, David C Christiani
Background: KDM lysine demethylase family members are related to lung cancer clinical outcomes and are potential biomarkers for chemotherapeutics. However, little is known about epigenetic alterations in KDM genes and their roles in lung cancer survival. Methods: Tumor tissue samples of 1230 early-stage non-small cell lung cancer (NSCLC) patients were collected from the five independent cohorts. The 393 methylation sites in KDM genes were extracted from epigenome-wide datasets and analyzed by weighted random forest (Ranger) in discovery phase and validation dataset, respectively...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29618620/orthoxenografts-of-testicular-germ-cell-tumors-demonstrate-genomic-changes-associated-with-cisplatin-resistance-and-identify-pdmp-as-a-re-sensitizing-agent
#7
Josep Maria Piulats, August Vidal, Francisco J García-Rodríguez, Clara Muñoz, Marga Nadal, Catia Moutinho, Maria Martínez-Iniesta, Josefina Mora, Agnes Figueras, Elisabet Guinó, Laura Padullés, Àlvaro Aytés, David G Mollevi, Sara Puertas, Carmen Martínez-Fernández, Wilmar Castillo, Merce Juliachs, Victor Moreno, Purificacion Muñoz, Milica Stefanovic, Miguel Angel Pujana, Enric Condom, Manel Esteller, Josep R Germà-LLuch, Gabriel Capella, Lourdes Farré, Albert Morales, Francesc Viñals, Xavier Garcia Del Muro, Julián Cerón, Alberto Villanueva
PURPOSE: To investigate the genetic basis of cisplatin resistance. Efficacy of cisplatin chemotherapy in the treatment of distinct malignancies is often hampered by intrinsic/ acquired drug resistance of tumors. EXPERIMENTAL DESIGN: We produced 14 orthoxenograft transplanting human nonseminomatous (NSE) testicular germ cell tumors (TGCTs) to mice, keeping the primary tumor features (genotype, phenotype and sensitivity to cisplatin). Chromosomal and genetic alterations were evaluated in matched cisplatin-sensitive and their counterpart orthoxenografts that developed resistance to cisplatin in vivo...
April 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29611843/spatial-distribution-of-arable-and-abandoned-land-across-former-soviet-union-countries
#8
Myroslava Lesiv, Dmitry Schepaschenko, Elena Moltchanova, Rostyslav Bun, Martina Dürauer, Alexander V Prishchepov, Florian Schierhorn, Stephan Estel, Tobias Kuemmerle, Camilo Alcántara, Natalia Kussul, Maria Shchepashchenko, Olga Kutovaya, Olga Martynenko, Viktor Karminov, Anatoly Shvidenko, Petr Havlik, Florian Kraxner, Linda See, Steffen Fritz
Knowledge of the spatial distribution of agricultural abandonment following the collapse of the Soviet Union is highly uncertain. To help improve this situation, we have developed a new map of arable and abandoned land for 2010 at a 10 arc-second resolution. We have fused together existing land cover and land use maps at different temporal and spatial scales for the former Soviet Union (fSU) using a training data set collected from visual interpretation of very high resolution (VHR) imagery. We have also collected an independent validation data set to assess the map accuracy...
April 3, 2018: Scientific Data
https://www.readbyqxmd.com/read/29611343/work-disability-in-argentinian-patients-with-systemic-lupus-erythematosus-is-prevalent-and-it-is-due-to-ethnic-socioeconomic-and-disease-related-factors
#9
Cecilia N Pisoni, Sebastián A Muñoz, María N Tamborenea, Mercedes García, Ana Curti, Ana Cappuccio, Oscar Rillo, Patricia M Imamura, Emilce Schneeberger, Marcela Ballent, Mario L Cousseau, Jorge Velasco Zamora, Verónica Saurit, Sergio Toloza, María C Danielsen, Verónica I Bellomio, Cesar Graf, Sergio Paira, Javier Cavallasca, Bernardo Pons Estel, José L C Moreno, Mónica Díaz, Paula Alba, Marcela Verando, Guillermo Tate, Eduardo Mysler, Judith Sarano, Emma E Civit, Fabián Risueño, Pablo Álvarez Sepúlveda, María S Larroude, Marcos F Méndez, Andrea Conforti, Débora Sohn
OBJECTIVE: To study the prevalence and the associated factors of work disability (WD) in systemic lupus erythematosus (SLE) patients. METHODS: A sample of 419 SLE patients from an observational cross-sectional multicenter study was included. Sociodemographic features, disease characteristics, comorbidities, quality of life, unhealthy behaviors, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not being able to work because of SLE...
April 2, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29605848/infinium-dna-methylation-microarrays-on-formalin-fixed-paraffin-embedded-samples
#10
Sebastian Moran, Manel Esteller
Formalin-fixed, paraffin-embedded (FFPE) samples usually yield fragmented DNA, which is incompatible with traditional Infinium Methylation beadchips. In this chapter, we aim to explain in detail all the processes carried out in order to obtain high-quality methylation profiles from FFPE samples through an FFPE restoration procedure. High-throughput methylation profiling platforms such as the Infinium Methylation beadchips have been extensively used by the scientific community to elucidate many hypotheses in multiple scenarios, now with the incorporation of FFPE samples to these platforms, a myriad of new opportunities is being opened...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29605847/cpg-islands-in-cancer-heads-tails-and-sides
#11
Humberto J Ferreira, Manel Esteller
DNA methylation is a dynamic epigenetic mark that characterizes different cellular developmental stages, including tissue-specific profiles. This CpG dinucleotide modification cooperates in the regulation of the output of the cellular genetic content, in both healthy and pathological conditions. According to endogenous and exogenous stimuli, DNA methylation is involved in gene transcription, alternative splicing, imprinting, X-chromosome inactivation, and control of transposable elements. When these dinucleotides are organized in dense regions are called CpG islands (CGIs), being commonly known as transcriptional regulatory regions frequently associated with the promoter region of several genes...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29605385/effects-of-apoe-%C3%AE%C2%B54-allele-load-on-brain-morphology-in-a-cohort-of-middle-aged-healthy-individuals-with-enriched-genetic-risk-for-alzheimer-s-disease
#12
Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Nina Gramunt, Manel Esteller, Sebastián Morán, Carolina Minguillón, Karine Fauria, Juan Domingo Gispert
INTRODUCTION: Apolipoprotein E (APOE)-ε4 is the major genetic risk factor for Alzheimer's disease. However, the dose-dependent impact of this allele on brain morphology of healthy individuals remains unclear. METHODS: We analyzed gray matter volumes (GMvs) in a sample of 533 healthy middle-aged individuals with a substantial representation of ε4-carriers (207 heterozygotes and 65 homozygotes). RESULTS: We found APOE-ε4 additive GMv reductions in the right hippocampus, caudate, precentral gyrus, and cerebellar crus...
March 27, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29605357/obstructive-sleep-apnea-syndrome-and-growth-failure
#13
E Esteller, J C Villatoro, A Agüero, R Lopez, E Matiñó, J Argemi, M Girabent-Farrés
Obstructive sleep apnea syndrome is a common problem among children and is recognized as a cause of significant medical morbidity. Since the 1980s, it has been suggested that obstructive sleep apnea syndrome is a risk factor for growth failure in children. In many cases, it has been shown that growth failure is reversible once the obstructive sleep apnea syndrome is resolved. The objectives of this study were to analyze and compare growth failure prevalence in a Mediterranean population of children with obstructive sleep apnea syndrome and healthy children matched in age and sex, and to assess the effectiveness of tonsillectomy and adenoidectomy in resolving growth retardation...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29605338/a-case-control-study-of-drug-induced-sleep-endoscopy-dise-in-pediatric-population-a-proposal-for-indications
#14
Maria Antonietta Collu, Eduard Esteller, Fiorella Lipari, Raul Haspert, Demetrio Mulas, Miguel Angel Diaz, Raghav C Dwivedi
OBJECTIVE: To evaluate whether and when Drug-Induced Sleep Endoscopy (DISE) changes diagnosis and treatment plan in pediatric Obstructive Sleep Apnoea Syndrome (OSAS) with the aim to identify specific subgroups of patients for whom DISE should be especially considered. METHODS: A case-control study of DISE in 150 children with OSAS. Pre-operative OSA were assessed through detailed history, Chervin questionnaire, physical examination and overnight polysomnography...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29599847/a-multiplatform-approach-identifies-mir-152-3p-as-a-common-epigenetically-regulated-onco-suppressor-in-prostate-cancer-targeting-tmem97
#15
João Ramalho-Carvalho, Céline S Gonçalves, Inês Graça, David Bidarra, Eva Pereira-Silva, Sofia Salta, Maria Inês Godinho, Antonio Gomez, Manel Esteller, Bruno M Costa, Rui Henrique, Carmen Jerónimo
Background: Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive. Herein, using combined analysis of microRNAs expression and genomewide DNA methylation, we aimed to identify epigenetically downregulated microRNAs in PCa. Results: We found that miR-152-3p was underexpressed in PCa and that lower expression levels were associated with promoter hypermethylation in accordance with TCGA dataset analysis...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29572501/array-based-dna-methylation-profiling-in-sarcomas-with-small-blue-round-cell-histology-provides-valuable-diagnostic-information
#16
Christian Koelsche, Wolfgang Hartmann, Daniel Schrimpf, Damian Stichel, Susanne Jabar, Andreas Ranft, David E Reuss, Felix Sahm, David T W Jones, Melanie Bewerunge-Hudler, Marcel Trautmann, Thomas Klingebiel, Christian Vokuhl, Manfred Gessler, Eva Wardelmann, Iver Petersen, Daniel Baumhoer, Uta Flucke, Cristina Antonescu, Manel Esteller, Stefan Fröhling, Marcel Kool, Stefan M Pfister, Gunhild Mechtersheimer, Uta Dirksen, Andreas von Deimling
Undifferentiated solid tumors with small blue round cell histology and expression of CD99 mostly resemble Ewing sarcoma. However, they also may include other tumors such as mesenchymal chondrosarcoma, synovial sarcoma, or small cell osteosarcoma. Definitive classification usually requires detection of entity-specific mutations. While this approach identifies the majority of Ewing sarcomas, a subset of lesions remains unclassified and, therefore, has been termed "Ewing-like sarcomas" or small blue round cell tumors not otherwise specified...
March 23, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29570897/methodological-challenges-when-evaluating-potential-off-label-prescribing-of-drugs-using-electronic-health-care-databases-a-case-study-of-dabigatran-etexilate-in-europe
#17
Miguel Cainzos-Achirica, Cristina Varas-Lorenzo, Anton Pottegård, Joelle Asmar, Estel Plana, Lotte Rasmussen, Geoffray Bizouard, Joan Forns, Maja Hellfritzsch, Kristina Zint, Susana Perez-Gutthann, Manel Pladevall-Vila
PURPOSE: To report and discuss estimated prevalence of potential off-label use and associated methodological challenges using a case study of dabigatran. METHODS: Observational, cross-sectional study using 3 databases with different types of clinical information available: Cegedim Strategic Data Longitudinal Patient Database (CSD-LPD), France (cardiologist panel, n = 1706; general practitioner panel, n = 2813; primary care data); National Health Databases, Denmark (n = 28 619; hospital episodes and dispensed ambulatory medications); and Clinical Practice Research Datalink (CPRD), UK (linkable to Hospital Episode Statistics [HES], n = 2150; not linkable, n = 1285; primary care data plus hospital data for HES-linkable patients)...
March 23, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29548821/histamine-receptor-1-inhibition-enhances-antitumor-therapeutic-responses-through-extracellular-signal-regulated-kinase-erk-activation-in-breast-cancer
#18
Patricia Fernández-Nogueira, Aleix Noguera-Castells, Gemma Fuster, Leire Recalde-Percaz, Núria Moragas, Anna López-Plana, Estel Enreig, Patricia Jauregui, Neus Carbó, Vanessa Almendro, Pedro Gascón, Paloma Bragado, Mario Mancino
Histamine receptor 1 (HRH1) belongs to the rhodopsin-like G-protein-coupled receptor family. Its activation by histamine triggers cell proliferation, embryonic development, and tumor growth. We recently established that HRH1 is up-regulated in basal and human epidermal growth factor receptor 2 (HER2)-enriched human breast tumors and that its expression correlates with a worse prognosis. Nevertheless, the functional role of HRH1 in basal and HER2-targeted therapy-resistant breast cancer (BC) progression has not yet been addressed...
March 13, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29531759/associations-between-cardiac-troponin-mortality-and-subsequent-use-of-cardiovascular-services-differences-in-sex-and-ethnicity
#19
David E Winchester, Kristopher Kline, Christopher Estel, Dhruv Mahtta, Sean Taasan, Franck W Peacock
Background: The impact of cardiac troponin (cTn) testing on the downstream use of cardiovascular services is not well understood. We conducted this large-scale single centre cohort study to investigate the patterns of testing that result from the use of cTn. Methods: We conducted this investigation using data collected between 1 January 2013 and 18 December 2015 from an academically affiliated tertiary care centre. Data from all hospitalised patients evaluated with cTn (Roche Elecsys cTn-T) assay were collected from our integrated data repository and divided into two cohorts: all cTn assays negative (<0...
2018: Open Heart
https://www.readbyqxmd.com/read/29478771/lipid-droplets-as-immune-modulators-in-myeloid-cells
#20
REVIEW
Martijn H den Brok, Tonke K Raaijmakers, Estel Collado-Camps, Gosse J Adema
Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important roles not only in diseases such as diabetes and cancer, but also in immune regulation. Alterations in immune cell function, such as myeloid cell activation, are connected to profound changes in LD numbers and LD protein composition. Thus, these organelles appear to be essential to metabolically support immune responses, and have a vital role in antigen crosspresentation, interferon (IFN) responses, production of inflammatory mediators, and pathogen clearance...
February 22, 2018: Trends in Immunology
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