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https://www.readbyqxmd.com/read/29157727/an-opportunistic-route-to-success-towards-a-change-of-paradigm-to-fully-exploit-the-potential-of-cell-penetrating-peptides
#1
Estel Collado Camps, Roland Brock
About 25years ago it was demonstrated that certain peptides possess the ability to cross the plasma membrane. This led to the development of cell-penetrating peptides (CPPs) as vectors to mediate the cellular entry of (macro-)molecules that do not show cell entry by themselves. Nonetheless, in spite of an early bloom of promising pre-clinical studies, not a single CPP-based drug has been approved, yet. It is a paradigm in CPP research that the peptides are taken up by virtually all cells. In exploratory research and early preclinical development, this assumption guides the choice of the therapeutic target...
November 4, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29135571/validation-of-cancer-cases-using-primary-care-cancer-registry-and-hospitalization-data-in-the-uk
#2
Andrea V Margulis, Joan Fortuny, James A Kaye, Brian Calingaert, Maria Reynolds, Estel Plana, Lisa J McQuay, Willem Jan Atsma, Billy Franks, Stefan de Vogel, Susana Perez-Gutthann, Alejandro Arana
BACKGROUND: In the United Kingdom, hospital or cancer registry data can be linked to electronic medical records for a subset of general practices and years. METHODS: We used Clinical Practice Research Datalink data (2004-2012) from patients treated for overactive bladder. We electronically identified provisional cases of 10 common cancers in General Practitioner Online Database data and validated them by medical profile review. In practices with linkage to Hospital Episodes Statistics and National Cancer Data Repository (2004-2010), we validated provisional cancer cases against these data sources...
November 9, 2017: Epidemiology
https://www.readbyqxmd.com/read/29133290/cd137-4-1bb-costimulation-modifies-dna-methylation-in-cd8-t-cell-relevant-genes
#3
M Angela Aznar, Sara Labiano, Angel Diaz-Lagares, Carmen Molina, Saray Garasa, Arantza Azpilicueta, Inaki Etxeberria, Alfonso R Sanchez-Paulete, Alan J Korman, Manel Esteller, Juan Sandoval, Ignacio Melero
CD137 (4-1BB) costimulation imprints long-term changes that instruct the ultimate behavior of T cells that have previously experienced CD137 ligation. Epigenetic changes could provide a suitable mechanism for these long-term consequences. Genome-wide DNA-methylation arrays were carried out on human peripheral blood CD8+ T lymphocytes stimulated with agonist monoclonal antibody to CD137, including urelumab, which is in phase I/II clinical trials for cancer immunotherapy. Several genes showed consistent methylation patterns in response to CD137 costimulation, which were confirmed by pyrosequencing in a series of healthy donors...
November 13, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29122981/in-situ-imaging-of-mitochondrial-translation-shows-weak-correlation-with-nucleoid-dna-intensity-and-no-suppression-during-mitosis
#4
Christopher Estell, Emmanouela Stamatidou, Sarah El-Messeiry, Andrew Hamilton
Although mitochondrial translation produces only 13 proteins, we show here how this can be labelled and detected in situ by fluorescence microscopy with a simple, rapid and inexpensive procedure using non-canonical amino acid labelling and click chemistry. This allows visualisation of the translational output in different mitochondria within a cell, their position within that cell and a comparison of mitochondrial translation between cells. Most highly translationally active mitochondria were closest to the nucleus but were also found at the distal end of long cellular projections...
November 9, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29119714/cross-cultural-adaptation-and-validation-of-the-spanish-version-of-the-paediatric-throat-disorders-outcome-test-t-14
#5
Francisco Larrosa, Laura Samara, Eduard Esteller, Maria J Dura, Yolanda Escamilla, Anna Alberti, Rosa Rosell, Claire Hopkins
OBJECTIVES: The Paediatric Throat Disorders Outcome Test (T-14) is a disease-specific questionnaire that parents are requested to complete; it aims to assess the quality of life related to tonsil and adenoid disease or its treatment in children with throat disorders. The aim of this study was to validate the Spanish adaptation of the T-14, thus allowing comparison across studies and facilitating international multicentre projects. DESIGN, SETTING AND PARTICIPANTS: This was a multicentre prospective instrument validation study...
November 9, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29103561/periocular-neoplasia-in-the-horse
#6
REVIEW
Krista Estell
Periocular neoplasia is common in horses. Treatment of the periocular skin and ocular adnexal structures can be technically challenging. Common neoplastic conditions, a treatment algorithm, surgical principles, and therapeutic modalities are reviewed. Regardless of the type of neoplasia found or the treatment that is applied, success is most likely when the neoplastic tumor is small.
December 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/29102072/experimental-evidence-of-warming-induced-flowering-in-the-mediterranean-seagrass-posidonia-oceanica
#7
J M Ruiz, L Marín-Guirao, R García-Muñoz, A Ramos-Segura, J Bernardeau-Esteller, M Pérez, N Sanmartí, Y Ontoria, J Romero, R Arthur, T Alcoverro, G Procaccini
Sexual reproduction in predominantly clonal marine plants increases recombination favoring adaptation and enhancing species resilience to environmental change. Recent studies of the seagrass Posidonia oceanica suggest that flowering intensity and frequency are correlated with warming events associated with global climate change, but these studies have been observational without direct experimental support. We used controlled experiments to test if warming can effectively trigger flowering in P. oceanica. A six-week heat wave was simulated under laboratory mesocosm conditions...
October 25, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29100665/sex-steroid-receptors-prostaglandin-e2-receptors-and-cyclooxygenase-in-the-equine-cervix-during-estrus-diestrus-and-pregnancy-gene-expression-and-cellular-localization
#8
Claudia B Fernandes, Shavahn C Loux, Kirsten E Scoggin, Edward L Squires, Mats H Troedsson, Alejandro Esteller-Vico, Barry A Ball
The cervix is a dynamic structure that undergoes dramatic changes during the estrous cycle, pregnancy and parturition. It is well established that hormonal changes, including estrogens, progestogens and prostaglandins, regulate the expression of key proteins involved in cervical function. The arachidonic acid cascade is important in the remodeling and relaxation of the cervix in the days preceding parturition. Despite the complexity of this mechanism, regulation of cervical function has received little study in the mare...
October 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29093158/effects-of-amerindian-genetic-ancestry-on-clinical-parameters-and-therapy-in-patients-with-rheumatoid-arthritis
#9
Elena Sánchez, Ignacio García de la Torre, Mónica Sacnún, Mario Goñi, Guillermo Berbotto, Sergio Paira, Jorge Luis Musuruana, César Graf, Alejandro Alvarellos, Osvaldo D Messina, Alejandra Babini, Ingrid Strusberg, Juan Carlos Marcos, Hugo Scherbarth, Alberto Spindler, Ana Quinteros, Sergio Toloza, José Luis C Moreno, Luis J Catoggio, Guillermo Tate, Alicia Eimon, Gustavo Citera, Antonio Catalán Pellet, Gustavo Nasswetter, Mario H Cardiel, Pedro Miranda, Francisco Ballesteros, Jorge A Esquivel-Valerio, Marco A Maradiaga-Ceceña, Eduardo M Acevedo-Vásquez, Conrado García García, Teresa Tusié-Luna, Bernardo A Pons-Estel, Marta E Alarcón-Riquelme
OBJECTIVE: To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America. METHODS: Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history. RESULTS: Percentage of Amerindian ancestry was comparable between cases and controls...
November 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29062026/early-onset-and-classical-forms-of-type-2-diabetes-show-impaired-expression-of-genes-involved-in-muscle-branched-chain-amino-acids-metabolism
#10
María Isabel Hernández-Alvarez, Angels Díaz-Ramos, María Berdasco, Jeff Cobb, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzystof Wanic, Declan O'Hanlon, Antonio Gomez, Laura R de la Ballina, Manel Esteller, Manuel Palacin, Donal J O'Gorman, John J Nolan, Antonio Zorzano
The molecular mechanisms responsible for the pathophysiological traits of type 2 diabetes are incompletely understood. Here we have performed transcriptomic analysis in skeletal muscle, and plasma metabolomics from subjects with classical and early-onset forms of type 2 diabetes (T2D). Focused studies were also performed in tissues from ob/ob and db/db mice. We document that T2D, both early and late onset, are characterized by reduced muscle expression of genes involved in branched-chain amino acids (BCAA) metabolism...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29059599/a-comparison-of-progesterone-assays-for-determination-of-peripheral-pregnane-concentrations-in-the-late-pregnant-mare
#11
Michelle A A Wynn, Alejandro Esteller-Vico, Erin L Legacki, Alan J Conley, Shavahn C Loux, Scott D Stanley, Thomas E Curry, Edward L Squires, Mats H Troedsson, Barry A Ball
During the latter half of gestation in mares, there is a complex milieu of pregnanes in peripheral blood. Progesterone concentrations are often assessed by immunoassay during late gestation as a measure of pregnancy well-being; however, interpretation of results is complicated by the numerous cross-reacting pregnanes present in high concentrations during late gestation. Further, many mares are supplemented with an exogenous progestin, altrenogest, which may also cross-react with existing assays and further confound interpretation...
October 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/29058695/dna-methylation-signal-has-a-major-role-in-the-response-of-human-breast-cancer-cells-to-the-microenvironment
#12
P Mathot, M Grandin, G Devailly, F Souaze, V Cahais, S Moran, M Campone, Z Herceg, M Esteller, P Juin, P Mehlen, R Dante
Breast cancer-associated fibroblasts (CAFs) have a crucial role in tumor initiation, metastasis and therapeutic resistance by secreting various growth factors, cytokines, protease and extracellular matrix components. Soluble factors secreted by CAFs are involved in many pathways including inflammation, metabolism, proliferation and epigenetic modulation, suggesting that CAF-dependent reprograming of cancer cells affects a large set of genes. This paracrine signaling has an important role in tumor progression, thus deciphering some of these processes could lead to relevant discoveries with subsequent clinical implications...
October 23, 2017: Oncogenesis
https://www.readbyqxmd.com/read/29046965/mother-infant-bonding-in-the-postpartum-period-assessment-of-the-impact-of-pre-delivery-factors-in-a-clinical-sample
#13
Borja Farré-Sender, Anna Torres, Estel Gelabert, Susana Andrés, Alba Roca, Gracia Lasheras, Manuel Valdés, Lluïsa Garcia-Esteve
This study aims to examine the extent to which a variety of pre-delivery factors (demographic, reproductive, psychological, psychiatric, and psychopathological) predict disturbances in mother-infant bonding (MIB) in the postpartum period. Two hundred fifty-one pregnant women enrolled at a public perinatal psychiatric service were assessed between the first and second trimester of pregnancy and at 6-7 weeks after delivery. During pregnancy, the psychological risk factors were assessed with the Vulnerable Personality Style Questionnaire, the Marital Adjustment Scale, the Early Trauma Inventory, and the General Health Questionnaire...
October 18, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28990663/adaptation-and-validation-of-the-spanish-version-of-the-tonsil-and-adenoid-health-status-instrument
#14
Laura Samara, Eduard Esteller, Maria J Dura, Miquel Guirao, Alda Cardesin, Michael Stewart, Francisco Larrosa
OBJECTIVES/HYPOTHESIS: The Tonsil and Adenoid Health Status Instrument (TAHSI) is a disease-specific questionnaire, intended for completion by parents, for assessing quality of life related to tonsil and adenoid disease or its treatment in children with throat disorders. The aim of this study was to validate the Spanish adaptation of the TAHSI, thus allowing comparison across studies and international multicenter projects. STUDY DESIGN: Multicenter prospective instrument validation study...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28982739/discovery-of-methylated-circulating-dna-biomarkers-for-comprehensive-non-invasive-monitoring-of-treatment-response-in-metastatic-colorectal-cancer
#15
Ludovic Barault, Alessio Amatu, Giulia Siravegna, Agostino Ponzetti, Sebastian Moran, Andrea Cassingena, Benedetta Mussolin, Chiara Falcomatà, Alexandra M Binder, Carmen Cristiano, Daniele Oddo, Simonetta Guarrera, Carlotta Cancelliere, Sara Bustreo, Katia Bencardino, Sean Maden, Alice Vanzati, Patrizia Zavattari, Giuseppe Matullo, Mauro Truini, William M Grady, Patrizia Racca, Karin B Michels, Salvatore Siena, Manel Esteller, Alberto Bardelli, Andrea Sartore-Bianchi, Federica Di Nicolantonio
OBJECTIVE: Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised assay design due to the lack of universally mutated genes. In contrast, early methylation alterations are restricted to defined genomic loci allowing comprehensive assay design for population studies. Our objective was to identify cancer-specific methylated biomarkers which could be measured longitudinally in cfDNA (liquid biopsy) to monitor therapeutic outcome in patients with metastatic CRC (mCRC)...
October 5, 2017: Gut
https://www.readbyqxmd.com/read/28981629/usefulness-of-transcriptional-blood-biomarkers-as-a-non-invasive-surrogate-marker-of-mucosal-healing-and-endoscopic-response-in-ulcerative-colitis
#16
Núria Planell, M Carme Masamunt, Raquel Franco Leal, Lorena Rodríguez, Miriam Esteller, Juan J Lozano, Anna Ramírez, Maria de Lourdes Setsuko Ayrizono, Claudio Saddy Rodrigues Coy, Ignacio Alfaro, Ingrid Ordás, Sudha Visvanathan, Elena Ricart, Jordi Guardiola, Julián Panés, Azucena Salas
Background and Aims: Ulcerative colitis [UC] is a chronic inflammatory disease of the colon. Colonoscopy remains the gold standard for evaluating disease activity, as clinical symptoms are not sufficiently accurate. The aim of this study is to identify new accurate non-invasive biomarkers based on whole-blood transcriptomics that can predict mucosal lesions and response to treatment in UC patients. Methods: Whole-blood samples were collected for a total of 152 UC patients at endoscopy...
October 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28977426/histone-h1-depletion-triggers-an-interferon-response-in-cancer-cells-via-activation-of-heterochromatic-repeats
#17
Andrea Izquierdo-Bouldstridge, Alberto Bustillos, Carles Bonet-Costa, Patricia Aribau-Miralbés, Daniel García-Gomis, Marc Dabad, Anna Esteve-Codina, Laura Pascual-Reguant, Sandra Peiró, Manel Esteller, Matthew Murtha, Lluís Millán-Ariño, Albert Jordan
Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) of each H1 variant in breast cancer cells results in altered gene expression and proliferation differently in a variant specific manner with H1.2 and H1.4 KDs being most deleterious. Here we show combined depletion of H1.2 and H1.4 has a strong deleterious effect resulting in a strong interferon (IFN) response, as evidenced by an up-regulation of many IFN-stimulated genes (ISGs) not seen in individual nor in other combinations of H1 variant KDs...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28939626/remission-and-low-disease-activity-status-ldas-protect-lupus-patients-from-damage-occurrence-data-from-a-multiethnic-multinational-latin-american-lupus-cohort-gladel
#18
Manuel Francisco Ugarte-Gil, Daniel Wojdyla, Guillermo J Pons-Estel, Luis J Catoggio, Cristina Drenkard, Judith Sarano, Guillermo A Berbotto, Eduardo F Borba, Emilia Inoue Sato, João C Tavares Brenol, Oscar Uribe, Luis A Ramirez Gómez, Marlene Guibert-Toledano, Loreto Massardo, Mario H Cardiel, Luis H Silveira, Rosa Chacón-Diaz, Graciela S Alarcón, Bernardo A Pons-Estel
OBJECTIVE: To evaluate disease activity statuses' (DAS') impact on systemic lupus erythematosus (SLE) outcomes. MATERIALS AND METHODS: Four DAS were defined: remission off-therapy: SLE Disease Activity Index (SLEDAI)=0, no prednisone or immunosuppressive drugs (IS); remission on-therapy: SLEDAI=0, prednisone ≤5 mg/day and/or IS (maintenance); low (L) DAS: SLEDAI ≤4, prednisone ≤7.5 mg/day and/or IS (maintenance); non-optimally controlled: SLEDAI >4 and/or prednisone >7...
December 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28931650/epigenetic-inactivation-of-tumour-suppressor-coding-and-non-coding-genes-in-human-cancer-an-update
#19
REVIEW
Pere Llinàs-Arias, Manel Esteller
Cancer cells undergo many different alterations during their transformation, including genetic and epigenetic events. The controlled division of healthy cells can be impaired through the downregulation of tumour suppressor genes. Here, we provide an update of the mechanisms in which epigenetically altered coding and non-coding tumour suppressor genes are implicated. We will highlight the importance of epigenetics in the different molecular pathways that lead to enhanced and unlimited capacity of division, genomic instability, metabolic shift, acquisition of mesenchymal features that lead to metastasis, and tumour plasticity...
September 2017: Open Biology
https://www.readbyqxmd.com/read/28925175/dream-to-become-dr-canady-inspires-an-aspiring-surgeon
#20
Estell Williams
No abstract text is available yet for this article.
February 2017: Bulletin of the American College of Surgeons
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