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https://www.readbyqxmd.com/read/28625273/development-of-a-core-outcome-set-for-disease-modification-trials-in-mild-to-moderate-dementia-a-systematic-review-patient-and-public-consultation-and-consensus-recommendations
#1
Lucy Webster, Derek Groskreutz, Anna Grinbergs-Saull, Rob Howard, John T O'Brien, Gail Mountain, Sube Banerjee, Bob Woods, Robert Perneczky, Louise Lafortune, Charlotte Roberts, Jenny McCleery, James Pickett, Frances Bunn, David Challis, Georgina Charlesworth, Katie Featherstone, Chris Fox, Claire Goodman, Roy Jones, Sallie Lamb, Esme Moniz-Cook, Justine Schneider, Sasha Shepperd, Claire Surr, Jo Thompson-Coon, Clive Ballard, Carol Brayne, Orlaith Burke, Alistair Burns, Linda Clare, Peter Garrard, Patrick Kehoe, Peter Passmore, Clive Holmes, Ian Maidment, Fliss Murtagh, Louise Robinson, Gill Livingston
BACKGROUND: There is currently no disease-modifying treatment available to halt or delay the progression of the disease pathology in dementia. An agreed core set of the best-available and most appropriate outcomes for disease modification would facilitate the design of trials and ensure consistency across disease modification trials, as well as making results comparable and meta-analysable in future trials. OBJECTIVES: To agree a set of core outcomes for disease modification trials for mild to moderate dementia with the UK dementia research community and patient and public involvement (PPI)...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28624764/recommended-core-items-to-assess-e-cigarette-use-in-population-based-surveys
#2
Jennifer L Pearson, Sara C Hitchman, Leonie S Brose, Linda Bauld, Allison M Glasser, Andrea C Villanti, Ann McNeill, David B Abrams, Joanna E Cohen
A consistent approach using standardised items to assess e-cigarette use in both youth and adult populations will aid cross-survey and cross-national comparisons of the effect of e-cigarette (and tobacco) policies and improve our understanding of the population health impact of e-cigarette use. Focusing on adult behaviour, we propose a set of e-cigarette use items, discuss their utility and potential adaptation, and highlight e-cigarette constructs that researchers should avoid without further item development...
June 17, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28624727/the-biogeochemical-implications-of-massive-gull-flocks-at-landfills
#3
R Scott Winton, Mark River
Gulls have long been observed concentrating in flocks of tens to hundreds of thousands at the anthropogenic food sources provided by landfills. Yet, the biogeochemical implications of the landfill gull phenomenon have been largely ignored. This study has two goals: 1) to understand the magnitude and geographic extent of landfill gulls in North America, and 2) to quantify the amount of carbon (C), nitrogen (N), and phosphorus (P) transported from landfills to gull roosting sites in order to understand their potential impacts on water quality and methane (CH4) emission...
June 8, 2017: Water Research
https://www.readbyqxmd.com/read/28617837/risk-factors-and-protective-factors-associated-with-incident-or-increase-of-frailty-among-community-dwelling-older-adults-a-systematic-review-of-longitudinal-studies
#4
Zeyun Feng, Marjolein Lugtenberg, Carmen Franse, Xinye Fang, Shanlian Hu, Chunlin Jin, Hein Raat
INTRODUCTION: Frailty is one of the greatest challenges facing our aging population, as it can lead to adverse outcomes such as institutionalization, hospitalization, and mortality. However, the factors that are associated with frailty are poorly understood. We performed a systematic review of longitudinal studies in order to identify the sociodemographic, physical, biological, lifestyle-related, and psychological risk or protective factors that are associated with frailty among community-dwelling older adults...
2017: PloS One
https://www.readbyqxmd.com/read/28617657/national-institutes-of-health-research-plan-on-rehabilitation
#5
Nih Medical Rehabilitation Coordinating Committee
One in five Americans experiences disability that affects their daily function because of impairments in mobility, cognitive function, sensory impairment, or communication impairment. The need for rehabilitation strategies to optimize function and reduce disability is a clear priority for research to address this public health challenge. The National Institutes of Health (NIH) recently published a Research Plan on Rehabilitation that provides a set of priorities to guide the field over the next 5 years. The plan was developed with input from multiple Institutes and Centers within the NIH, the National Advisory Board for Medical Rehabilitation Research, and the public...
2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28616806/ipragliflozin-reduces-epicardial-fat-accumulation-in-non-obese-type-2-diabetic-patients-with-visceral-obesity-a-pilot-study
#6
Tatsuya Fukuda, Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
INTRODUCTION: Epicardial fat (EF) was reported to be independently associated with cardiovascular disease regardless of obesity. We have previously reported that a sodium-glucose co-transporter-2 (SGLT2) inhibitor, luseogliflozin, reduces the EF volume (EFV) in parallel with the reduction of body weight in obese patients (BMI ≥25 kg/m(2)) with type 2 diabetes. However, it is unknown whether SGLT2 inhibitors could reduce EFV in non-obese patients (BMI <25 kg/m(2)) with type 2 diabetes...
June 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28616689/the-reality-of-scientific-research-in-latin-america-an-insider-s-perspective
#7
Daniel R Ciocca, Gabriela Delgado
There is tremendous disparity in scientific productivity among nations, particularly so in Latin America. At first sight, this could be linked to the relative economic health of the different countries of the region, but even large and relatively rich Latin American countries do not produce a good level of science. Although Latin America has increased the number of its scientists and research institutions in recent years, the gap between developed countries and Latin American countries is startling. The prime importance of science and technology to the development of a nation remains unacknowledged...
June 14, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28616040/stem-cell-transplantation-for-spinal-cord-injury-a-meta-analysis-of-treatment-effectiveness-and-safety
#8
Xiao Fan, Jin-Zhao Wang, Xiao-Min Lin, Li Zhang
OBJECTIVE: The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES: PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by computer to select clinical randomized controlled trials using stem cell transplantation to treat SCI, published between each database initiation and July 2016...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28615509/total-fluid-consumption-and-risk-of-bladder-cancer-a-meta-analysis-with-updated-data
#9
Qinyu Liu, Banghua Liao, Ye Tian, Yuntian Chen, Deyi Luo, Yifei Lin, Hong Li, Kun-Jie Wang
With meta-analysis we tented to reveal the potential relationship between daily fluid consumption and bladder cancer risk, and to find out a recommendation on daily fluid intake. Databases of the Web of Science, PubMed and EMBASE were searched then 21 case-control and 5 cohort studies were included. Stratified analyses on gender, region, time of subjects recruiting and fluid quantity were performed as well as dose-response meta-analysis. Comparing the highest exposure category with the lowest in each study, no association appeared when all data pooled together (p=0...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28612838/drinking-water-consumption-patterns-among-adults-sms-as-a-novel-tool-for-collection-of-repeated-self-reported-water-consumption
#10
Melle Säve-Söderbergh, Jonas Toljander, Irene Mattisson, Agneta Åkesson, Magnus Simonsson
Studies have shown that the average drinking water consumption ranges between 0.075 and 3 L/day for adults with both national and regional differences. For exposure assessment of drinking water hazards, country-specific drinking water consumption data including sources of the consumed water may therefore be warranted. To estimate the amount and source of drinking water consumed among adults in Sweden, we collected self-reported estimates using both traditional methods (telephone interviews, web questionnaire) and a novel method (Short Message Service, SMS questionnaires) in a population from an average sized Swedish municipality...
June 14, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28611975/effect-of-promotional-initiatives-on-visits-to-a-dedicated-website-for-physical-activity-and-non-communicable-disease-in-luxembourg-an-event-study
#11
Alexis Lion, Jane S Thornton, Michel Vaillant, Juliette Pertuy, Eric Besenius, Cyrille Hardy, Charles Delagardelle, Romain Seil, Axel Urhausen, Daniel Theisen
The Sport-Santé project and its website (www.sport-sante.lu) promote physical activity for individuals with non-communicable diseases (NCDs) in Luxembourg. Our purpose was to perform an event study analysis to evaluate the effects of communication and promotional initiatives on the number of visits to the Sport-Santé website. Between September 2015 and May 2016, the Sport-Santé website was promoted during different initiatives, including participation in health-related events or publication of articles in local journals...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28607636/impact-of-garlic-tablets-on-nosocomial-infections-in-hospitalized-patients-in-intensive-care-units
#12
Hossein Madineh, Farrokh Yadollahi, Farshad Yadollahi, Ebrahim Pouria Mofrad, Majid Kabiri
BACKGROUND: Nosocomial infections are one of the main causes of mortality and morbidity in hospitals, especially in intensive care units (ICUs). OBJECTIVE: The aim of this study was to examine the impact of garlic tablets on nosocomial infections in hospitalized patients in intensive care units. METHODS: This clinical trial was carried out on 94 patients, admitted to the intensive care units in Kashani and Al-Zahra hospitals from January 21, 2014 to December 20, 2014...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28606894/developing-a-curriculum-for-information-and-communications-technology-use-in-global-health-research-and-training-a-qualitative-study-among-chinese-health-sciences-graduate-students
#13
Zhenyu Ma, Li Yang, Lan Yang, Kaiyong Huang, Hongping Yu, Huimin He, Jiaji Wang, Le Cai, Jie Wang, Hua Fu, Lisa Quintiliani, Robert H Friedman, Jian Xiao, Abu S Abdullah
BACKGROUND: Rapid development of information and communications technology (ICT) during the last decade has transformed biomedical and population-based research and has become an essential part of many types of research and educational programs. However, access to these ICT resources and the capacity to use them in global health research are often lacking in low- and middle-income country (LMIC) institutions. OBJECTIVE: The aim of our study was to assess the practical issues (ie, perceptions and learning needs) of ICT use among health sciences graduate students at 6 major medical universities of southern China...
June 12, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28605151/perceptions-of-smartphone-user-centered-mobile-health-tracking-apps-across-various-chronic-illness-populations-an-integrative-review
#14
Susan D Birkhoff, Suzanne C Smeltzer
PURPOSE: This integrative review presents a synthesis of the current qualitative research addressing the motivating factors, usability, and experiences of mobile health tracking applications (apps) across various chronic disease populations. DESIGN: Integrative review of the literature. METHODS: Databases used to conduct this integrative review included: PubMed Plus, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Google Scholar, Science Direct, and EBSCO megafile...
June 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28602027/assistive-technology-for-memory-support-in-dementia
#15
REVIEW
Henriëtte G Van der Roest, Jennifer Wenborn, Channah Pastink, Rose-Marie Dröes, Martin Orrell
BACKGROUND: The sustained interest in electronic assistive technology in dementia care has been fuelled by the urgent need to develop useful approaches to help support people with dementia at home. Also the low costs and wide availability of electronic devices make it more feasible to use electronic devices for the benefit of disabled persons. Information Communication Technology (ICT) devices designed to support people with dementia are usually referred to as Assistive Technology (AT) or Electronic Assistive Technology (EAT)...
June 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28600111/do-active-video-games-benefit-the-motor-skill-development-of-non-typically-developing-children-and-adolescents-a-systematic-review
#16
REVIEW
Zoey E Page, Stephanie Barrington, Jacqueline Edwards, Lisa M Barnett
OBJECTIVES: The use of interactive video gaming, known as 'exergames' or 'active video games (AVG)' may provide an opportunity for motor skill development. Youth with non-typical patterns of development may have deficits in gross motor skill capacities and are therefore an intervention target. The aim was to determine the effectiveness of AVG use on motor skill development in non-typically developing children and adolescents. DESIGN: Review article. METHODS: The PRISMA protocol was used to conduct a systematic review of EBSCOhost, Embase, Gale Cengage, Informit, Ovid, ProQuest, PubMed, Scopus and Web of Science databases...
May 18, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28585719/toward-a-community-ecology-of-landscapes-predicting-multiple-predator-prey-interactions-across-geographic-space
#17
Oswald J Schmitz, Jennifer R B Miller, Anne M Trainor, Briana Abrahms
Community ecology was traditionally an integrative science devoted to studying interactions between species and their abiotic environments in order to predict species' geographic distributions and abundances. Yet for philosophical and methodological reasons it has become divided into two enterprises: one devoted to local experimentation on species interactions to predict community dynamics; the other devoted to statistical analyses of abiotic and biotic information to describe geographic distribution. Our goal here is to instigate thinking about ways to reconnect the two enterprises and thereby return to a tradition to do integrative science...
June 6, 2017: Ecology
https://www.readbyqxmd.com/read/28585690/satisfying-america-s-fruit-gap-summary-of-an-expert-roundtable-on-the-role-of-100-fruit-juice
#18
REVIEW
Carol Byrd-Bredbenner, Mario G Ferruzzi, Victor L Fulgoni, Robert Murray, Elizabeth Pivonka, Taylor C Wallace
The 2015 to 2020 Dietary Guidelines for Americans (DGAs) recognize the role of 100% fruit juice in health and in helping people meet daily fruit recommendations and state that 100% fruit juice is a nutrient-dense beverage that should be a primary choice, along with water and low-fat/fat-free milk. The DGAs note that children are consuming 100% fruit juice within recommendations (that is, 120 to 180 mL/d for children aged 1 to 6 y and 236 to 355 mL/d for children aged 7 to 18 y). Evidence shows that compared to nonconsumers, those who consume 100% fruit juice come closer to meeting daily fruit needs and have better diet quality...
June 6, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28584930/the-reality-of-scientific-research-in-latin-america-an-insider-s-perspective
#19
Daniel R Ciocca, Gabriela Delgado
There is tremendous disparity in scientific productivity among nations, particularly in Latin America. At first sight, this could be linked to the relative economic health of the different countries of the region, but even large and relatively rich Latin American countries do not produce a good level of science. Although Latin America has increased the number of its scientists and research institutions in recent years, the gap between developed countries and Latin American countries is startling. The prime importance of science and technology to the development of a nation remains unacknowledged...
June 5, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28584790/ameliorative-effects-of-nilotinib-on-ccl4-induced-liver-fibrosis-via-attenuation-of-rage-hmgb1-gene-expression-and-oxidative-stress-in-rat
#20
Vahid Khanjarsim, Jamshid Karimi, Iraj Khodadadi, Adel Mohammadalipour, Mohammad Taghi Goodarzi, Ghasem Solgi, Mohammad Hashemnia
Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL4. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-α and TGF-β mRNA expression were evaluated by quantitative RT-PCR...
May 2017: Chonnam Medical Journal
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