keyword
MENU ▼
Read by QxMD icon Read
search

OT

keyword
https://www.readbyqxmd.com/read/28214580/localization-of-oxytocin-receptors-in-the-prairie-vole-microtus-ochrogaster-neocortex
#1
Auriane Duchemin, Adele M H Seelke, Trenton C Simmons, Sara M Freeman, Karen L Bales
Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in these cortical processes. However, little is known about the distribution of OT and OT receptors (OTR) within the neocortex. Using autoradiographic and neuroanatomical techniques, we characterized the cortical distribution of oxytocin receptors (OTR) in prairie voles, a socially monogamous rodent species...
February 15, 2017: Neuroscience
https://www.readbyqxmd.com/read/28214044/enhancement-of-antigen-specific-cd4-and-cd8-t-cell-responses-using-a-self-assembled-biologic-nanolipoprotein-particle-vaccine
#2
Dina Weilhammer, Alexis D Dunkle, Craig D Blanchette, Nicholas O Fischer, Michele Corzett, Doerte Lehmann, Tyler Boone, Paul Hoeprich, Adam Driks, Amy Rasley
To address the need for vaccine platforms that induce robust cell-mediated immunity, we investigated the potential of utilizing self-assembling biologic nanolipoprotein particles (NLPs) as an antigen and adjuvant delivery system to induce antigen-specific murine T cell responses. We utilized OT-I and OT-II TCR-transgenic mice to investigate the effects of NLP-mediated delivery of the model antigen ovalbumin (OVA) on T cell activation. Delivery of OVA with the TLR4 agonist monophosphoryl lipid A (MPLA) in the context of NLPs significantly enhanced the activation of both CD4(+) and CD8(+) T cells in vitro compared to co-administration of free OVA and MPLA...
February 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28212520/adp-ribosyl-cyclases-cd38-cd157-social-skills-and-friendship
#3
Anne Chong, Fabio Malavasi, Salomon Israel, Chiea Chuen Khor, Von Bing Yap, Mikhail Monakhov, Soo Hong Chew, Poh San Lai, Richard P Ebstein
Why some individuals seek social engagement while others shy away has profound implications for normal and pathological human behavior. Evidence suggests that oxytocin (OT), the paramount human social hormone, and CD38 that governs OT release, contribute to individual differences in social skills from intense social involvement to extreme avoidance that characterize autism. To explore the neurochemical underpinnings of sociality, CD38 expression of peripheral blood leukocytes (PBL) was measured in Han Chinese undergraduates...
January 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28209160/odontogenic-tumors-in-ethiopia-eight-years-retrospective-study
#4
Bruktawit Kebede, Dawit Tare, Birke Bogale, Fessahaye Alemseged
BACKGROUND: Odontogenic tumor (OT) comprises a large heterogeneous group of lesions arising from tooth producing tissues or its remnants. Studies on OTs are scarce in Ethiopia. Thus, the present study aimed to assess the pattern of OTs in Ethiopia. METHODS: An 8 years retrospective study was conducted at the Dental and Maxillofacial Department, St. Paul's referral hospital, Addis Ababa, Ethiopia. Data were collected by reviewing the medical records of patients who visited the Department from September 2008 to August 2015...
February 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28207842/evaluating-evidence-based-health-care-teaching-and-learning-in-the-undergraduate-human-nutrition-occupational-therapy-physiotherapy-and-speech-language-and-hearing-therapy-programs-at-a-sub-saharan-african-academic-institution
#5
Anel Schoonees, Anke Rohwer, Taryn Young
BACKGROUND: It is important that all undergraduate healthcare students are equipped with evidence-based health care (EBHC) knowledge and skills to encourage evidence-informed decision-making after graduation. We assessed EBHC teaching and learning in undergraduate human nutrition (HN); occupational therapy (OT); physiotherapy (PT); and speech, language and hearing therapy (SPLH) programs at a sub-Saharan African university. METHODS: We used methodological triangulation to obtain a comprehensive understanding of EBHC teaching and learning: (1) through a document review of module guides, we identified learning outcomes related to pre-specified EBHC competencies; we conducted (2) focus group discussions and interviews of lecturers to obtain their perspectives on EBHC and on EBHC teaching and learning; and we (3) invited final year students (2013) and 2012 graduates to complete an online survey on EBHC attitudes, self-perceived EBHC competence, and their experience of EBHC teaching and learning...
2017: PloS One
https://www.readbyqxmd.com/read/28207390/fast-and-accurate-rat-head-motion-tracking-with-point-sources-for-awake-brain-pet
#6
Alan Miranda, Steven Staelens, Sigrid Stroobants, Jeroen Verhaeghe
To avoid the confounding effects of anesthesia and immobilization stress in rat brain positron emission tomography (PET), motion tracking based unrestrained awake rat brain imaging is being developed. In this work we propose a fast and accurate rat head motion tracking method based on small PET point sources. PET point sources (3-4) attached to the rat's head are tracked in image space using 15-32 ms time frames. Our point source tracking (PST) method was validated using a manually moved microDerenzo phantom that was simultaneously tracked with an optical tracker (OT) for comparison...
February 13, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28203212/influence-of-ongoing-task-difficulty-and-motivation-level-on-children-s-prospective-memory-in-a-chinese-sample
#7
Pi-Guo Han, Lei Han, Yu-Long Bian, Yu Tian, Min-Xia Xu, Feng-Qiang Gao
Prospective memory (PM) is the process associated with the task of realizing delayed intentions in the future. Researchers distinguish two types of PM, namely time-based PM (tbPM) and event-based PM (ebPM). Experiment 1 investigated the developmental trajectory of 3- to 5-year-old preschool children's PM ability, and the occurrence of delayed retrieval (children execute the PM task in a larger window of opportunity) in both tbPM and ebPM tasks. Results revealed that the 5-year-old children outperformed the 3- and 4-year-old children in PM...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28201870/self-organization-induced-by-self-assembly-in-microheterogeneous-reaction-diffusion-system
#8
Alexander A Cherkashin, Vladimir K Vanag
When acrylamide (AA) monomers are added to the Belousov-Zhabotinsky (BZ) reaction incorporated into nanodroplets of water-in-oil aerosol OT (AOT) microemulsion (the BZ-AOT system), free radicals produced in the BZ reaction initiate polymerization of AA monomers and polyacrylamide particles are formed. These particles change the microstructure of the AOT microemulsion thus inducing the transition from Turing patterns to new dissipative patterns which can be either stationary "black" spots or waves.
February 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28197842/optimally-tuned-functionals-improving-the-description-of-optical-and-electronic-properties-of-the-phthalocyanine-molecule
#9
Tamires Lima Pereira, Luciano Almeida Leal, Wiliam Ferreira da Cunha, Rafael Timóteo de Sousa Júnior, Luiz Antonio Ribeiro Junior, Demétrio Antonio da Silva Filho
By means of Density functional theory and time-dependent density functional theory calculations, we present a comprehensive investigation on the influence of different functional schemes on electronic and optical properties of the phthalocyanine molecule. By carrying out our own tuning on the OT-LC-BLYP/6-31G(d,p) functional, we show that such a procedure is fundamental to accurately match experimental results. We compare our results to several others available in the literature, including the B3LYP/6-31+G(d,p) set, which is commonly portrayed as the best combination in order to obtain a good description of the band gap...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28194725/otophylloside-b-protects-against-a%C3%AE-toxicity-in-caenorhabditis-elegans-models-of-alzheimer-s-disease
#10
Jie Yang, Xiao-Bing Huang, Qin-Li Wan, Ai-Jun Ding, Zhong-Lin Yang, Ming-Hua Qiu, Hua-Ying Sun, Shu-Hua Qi, Huai-Rong Luo
Alzheimer's disease (AD) is a major public health concern worldwide and the few drugs currently available only treat the symptoms. Hence, there is a strong need to find more effective anti-AD agents. Cynanchum otophyllum is a traditional Chinese medicine for treating epilepsy, and otophylloside B (Ot B), isolated from C. otophyllum, is the essential active component. Having previously identified anti-aging effects of Ot B, we evaluated Ot B for AD prevention in C. elegans models of AD and found that Ot B extended lifespan, increased heat stress-resistance, delayed body paralysis, and increased the chemotaxis response...
February 13, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28188254/differential-effects-of-oxytocin-receptor-antagonists-atosiban-and-nolasiban-on-ot-mediated-signalling-in-human-amnion-and-myometrium
#11
Sung Hye Kim, Oliver Pohl, Andre Chollet, Jean-Pierre Gotteland, Adam D J Fairhurst, Phillip R Bennett, Vasso Terzidou
One of the most established roles of oxytocin (OT) is in inducing uterine contractions and labour. Apart from contractions, our recent study have shown that OT can also activate pro-inflammatory pathways in both human myometrial and amnion cells which suggests the pro-inflammatory role of OT should be taken into account when developing tocolytics targeting the OT/OT receptor (OT/OTR) system. The OTR antagonist, Atosiban, is currently used therapeutically for the treatment of PTL. We have previously shown that Atosiban fails to inhibit the pro-inflammatory effects of OT in human amnion, and Atosiban alone activates NF-κB and MAPKs thus upregulating downstream pro-labour genes...
February 10, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28186489/folding-behavior-of-a-t-shaped-ribosome-binding-translation-enhancer-implicated-in-a-wide-spread-conformational-switch
#12
My-Tra Le, Wojciech K Kasprzak, Taejin Kim, Feng Gao, Megan Yl Young, Xuefeng Yuan, Bruce A Shapiro, Joonil Seog, Anne E Simon
Turnip crinkle virus contains a T-shaped, ribosome-binding, translation enhancer (TSS) in its 3'UTR that serves as a hub for interactions throughout the region. The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surrounding region to undergo a conformational shift postulated to inhibit translation. Using optical tweezers (OT) and steered molecular dynamic simulations (SMD), we found that the unusual stability of pseudoknotted element H4a/Ψ3 required five upstream adenylates, and H4a/Ψ3 was necessary for cooperative association of two other hairpins (H5/H4b) in Mg(2+)...
February 10, 2017: ELife
https://www.readbyqxmd.com/read/28181357/post-embryonic-fish-brain-proliferation-zones-exhibit-neuroepithelial-type-gene-expression-profile
#13
E Dambroise, M Simion, T Bourquard, S Bouffard, B Rizzi, Y Jaszczyszyn, M Bourge, P Affaticati, A Heuzé, J Jouralet, J Edouard, S Brown, C Thermes, A Poupon, E Reiter, F Sohm, F Bourrat, J-S Joly
In mammals, neuroepithelial cells play an essential role in embryonic neurogenesis, whereas glial stem cells are the principal source of neurons at post-embryonic stages. By contrast, neuroepithelial-like stem/progenitor (NE) cells have been shown to be present throughout life in teleosts. We used 3-dimensional (3D) reconstructions of cleared transgenic wdr12:GFP medaka brains to demonstrate that this cell type is widespread in juvenile and to identify new regions containing NE cells. We established the gene expression profile of optic tectum (OT) NE cells by cell sorting followed by RNA-seq...
February 9, 2017: Stem Cells
https://www.readbyqxmd.com/read/28170396/moxibustion-for-pain-relief-in-patients-with-primary-dysmenorrhea-a-randomized-controlled-trial
#14
Mingxiao Yang, Xiangzhu Chen, Linna Bo, Lixing Lao, Jiao Chen, Siyi Yu, Zheng Yu, Hongzhi Tang, Ling Yi, Xi Wu, Jie Yang, Fanrong Liang
BACKGROUND: Though moxibustion is frequently used to treat primary dysmenorrhea in China, relevant evidence supporting its effectiveness is still scanty. METHODS: This study was a pragmatic randomized, conventional drug controlled, open-labeled clinical trial. After initial screen, 152 eligible participants were averagely randomized to receive two different treatment strategies: Moxibustion and conventional drugs. Participants and practitioners were not blinded in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28168056/the-influence-of-speech-language-hearing-therapy-duration-on-the-degree-of-improvement-in-poststroke-language-impairment
#15
Hitoshi Hayashi, Eisaku Okada, Yosuke Shibata, Mieko Nakamura, Toshiyuki Ojima
Background. The relevance of speech-language-hearing therapy (ST) duration to language impairment remains unclear. Objective. To determine the effect of ST duration on improvement in language impairment as a stroke sequela and to compare the findings with those for occupational therapy (OT) and physical therapy (PT). Methods. Data regarding patients with stroke sequelae who were registered in the Japanese Association of Rehabilitation Medicine database were analyzed. Propensity scores for ST, OT, and PT duration were calculated using logistic regression, followed by inverse probability weighting in generalized estimating equations to examine the odds ratio for improvement in the Functional Independence Measures scores for comprehension, expression, and memory...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28166469/promoting-translational-research-among-movement-science-occupational-science-and-occupational-therapy
#16
Robert L Sainburg, Sook-Lei Liew, Scott H Frey, Florence Clark
Integration of research in the fields of neural control of movement and biomechanics (collectively referred to as movement science) with the field of human occupation directly benefits both areas of study. Specifically, incorporating many of the quantitative scientific methods and analyses employed in movement science can help accelerate the development of rehabilitation-relevant research in occupational therapy (OT) and occupational science (OS). Reciprocally, OT and OS, which focus on the performance of everyday activities (occupations) to promote health and well-being, provide theoretical frameworks to guide research on the performance of actions in the context of social, psychological, and environmental factors...
February 6, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28163019/interrelationships-between-ovarian-follicles-grown-in-culture-and-possible-mediators
#17
Alexander V Sirotkin, Iveta Florkovičová Koničková, Hans-Jorg Schaeffer, Jozef Laurincik, Abdel Halim Harrath
Dominance or cooperation between ovarian follicles can determine the number of ovulations and fecundity, but interrelationships between follicles in mono- and poly-ovulatory species and their mechanisms are poorly understood. The goals of this work were to determine the existence and compare the character of mutual influence of cultured ovarian follicles from a mono-ovulatory species (cow) with established follicular dominance with those from a poly-ovulatory species (pig), in which interrelationship between follicles remain unknown, and to examine the role of ovarian cell proliferation, the insulin-like growth factor I (IGF-I)- oxytocin (OT) system, and steroid hormones in mediating interrelationships among ovarian follicles...
February 2, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28161387/temporary-removal-intranasal-oxytocin-but-not-vasopressin-augments-neural-responses-to-toddlers-in-human-fathers
#18
Ting Li, Xu Chen, Jennifer Mascaro, Ebrahim Haroon, James K Rilling
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
February 1, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28161382/association-of-serum-pancreatic-derived-factor-pander-with-beta-cell-dysfunction-in-type-2-diabetes-mellitus
#19
Miral M Shehata, Mohamed M Kamal, Mohamed H El-Hefnawy, Hala O El-Mesallamy
AIM: Beta-cell dysfunction is the critical determinant for type 2 diabetes. The novel PANcreatic DERived factor (PANDER) has been identified as interesting islet-secreted cytokine that might be involved in beta-cell dysfunction, a role that has n"ot been clinically elucidated yet. Therefore, this study was designed to study the potential clinical association of this cytokine with beta-cell dysfunction in type 2 diabetes. METHODS: Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers...
January 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28161309/oxytocin-differentially-alters-resting-state-functional-connectivity-between-amygdala-subregions-and-emotional-control-networks-inverse-correlation-with-depressive-traits
#20
Monika Eckstein, Sebastian Markett, Keith M Kendrick, Beate Ditzen, Fang Liu, Rene Hurlemann, Benjamin Becker
The hypothalamic neuropeptide oxytocin (OT) has received increasing attention for its role in modulating social-emotional processes across species. Previous studies on using intranasal-OT in humans point to a crucial engagement of the amygdala in the observed neuromodulatory effects of OT under task and rest conditions. However, the amygdala is not a single homogenous structure, but rather a set of structurally and functionally heterogeneous nuclei that show distinct patterns of connectivity with limbic and frontal emotion-processing regions...
February 1, 2017: NeuroImage
keyword
keyword
65527
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"