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https://www.readbyqxmd.com/read/29790420/olfactory-training-in-posttraumatic-smell-impairment-mild-improvement-in-threshold-performances-results-from-a-randomized-controlled-trial
#1
Cristobal Langdon, Eduardo Lehrer, Sara Laxe, Isam Alobid, Llorenç Quinto, Joan Berenguer, Franklin Mariño, Montserrat Bernabeu, Concepcio Marin, Joaquim Mullol
Traumatic Brain Injury (TBI) can be associated with partial or total smell loss. Recent studies have suggested that olfactory outcome can be positively modulated after olfactory training (OT). This study's aim was to investigate OT's potential role in smell recovery after TBI-induced olfactory loss. A prospective, randomized, and controlled study was developed. Patients with TBI-induced olfactory dysfunction (N = 42) were randomized into an experimental group with OT and a control group without (nOT). OT was performed twice daily with a 6-odor training set during 12 weeks...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29790335/accurate-electron-nucleus-distances-from-paramagnetic-relaxation-enhancements
#2
Henry W Orton, Gottfried Otting
Measurements of paramagnetic relaxation enhancements (PRE) in 1H-NMR spectra are an important tool to obtain long-range distance information in proteins, but quantitative interpretation is easily compromised by non-specific intermolecular PREs. Here we show that PREs generated by lanthanides with anisotropic magnetic susceptibilities offer a route to accurate calibration-free distance measurements. As these lanthanides change 1H chemical shifts due to pseudocontact shifts, the relaxation rates in the paramagnetic and diamagnetic state can be measured with a single sample that simultaneously contains the protein labeled with a paramagnetic and a diamagnetic lanthanide ion...
May 23, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29788320/chronic-variable-stress-induces-sex-specific-alterations-in-social-behavior-and-neuropeptide-expression-in-the-mouse
#3
Amanda P Borrow, Natalie J Bales, Sally A Stover, Robert J Handa
Chronic exposure to stressors impairs the function of multiple organ systems and is implicated in increased disease risk. In the rodent, the chronic variable stress (CVS) paradigm has successfully modeled several stress-related illnesses. Despite striking disparities between men and women in the prevalence and etiology of disorders associated with chronic stress, most preclinical research examining chronic stressor exposure has focused on male subjects. One potential mediator of the consequences of CVS is oxytocin (OT), a known regulator of stress neurocircuitry and behaviors...
May 16, 2018: Endocrinology
https://www.readbyqxmd.com/read/29788193/ocular-toxoplasmosis-adverse-reactions-to-treatment-in-a-brazilian-cohort
#4
Lusiele Guaraldo, Bianca Balzano de la Fuente Villar, Nicolle Marins Gomes Durão, Virgínia Clare Louro, Marcel de Souza Borges Quintana, André Luiz Land Curi, Elizabeth Souza Neves
Background: The purpose of this study was to estimate the frequency and describe the adverse drug reactions (ADRs) associated with the classic treatment of ocular toxoplasmosis (OT), namely sulfadiazine, pyrimethamine, corticosteroids and folinic acid. Methods: We performed a descriptive study of a prospective cohort of patients with OT treated with the classic therapy. Data were collected during medical consultations and treatment. Results: Of the 147 patients studied, 85% developed one or more ADR...
May 19, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29785126/impact-of-targeting-transforming-growth-factor-%C3%AE-2-with-antisense-ot-101-on-the-cytokine-and-chemokine-profile-in-patients-with-advanced-pancreatic-cancer
#5
Osmond J D'Cruz, Sanjive Qazi, Larn Hwang, Kevin Ng, Vuong Trieu
Background: Overexpression of the cytokine - transforming growth factor-beta 2 (TGF-β2) - has been implicated in the malignant progression of pancreatic cancer (PAC). OT-101 (trabedersen) is an antisense oligodeoxynucleotide designed to target the human TGF-β2 mRNA. In a Phase I/II study, OT-101 treatment with subsequent chemotherapy was characterized by outstanding overall survival (OS) in patients with PAC. Objective: This study sought to identify 1) co-regulated sets of cyto-/chemokines; 2) potential mechanisms that link TGF-β receptor type 2 receptor inhibition that may result in the induction of a cytokine storm; and 3) predictive biomarkers for OS outcome in OT-101-treated patients with PAC...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29780295/successful-in-vitro-fertilization-and-embryo-transfer-after-transplantation-of-cryopreserved-ovarian-tissue-report-of-the-first-korean-case
#6
Jung Ryeol Lee, Dayong Lee, Soohyeon Park, Eun Chan Paik, Seul Ki Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
For patients at risk of premature ovarian failure with cancer treatment, it is an important option to re-implant the ovarian tissue (OT) after cryopreservation to preserve endocrine function and fertility. With this technique, about 30% of pregnancy success rate and about 90 live births have been reported to date. However, there has been no case report of successful in vitro fertilization (IVF) and embryo transfer (ET) with oocytes collected from transplanted cryopreserved OT in Korea. We report a 30-year old woman with rectal cancer who underwent IVF and ET after cryopreserved OT thawing and re-implantation...
May 21, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29779048/increased-il-27-il-27r-expression-in-association-with-the-immunopathology-of-murine-ocular-toxoplasmosis
#7
Xinxin Tong, Shengjie Chen, Huanqin Zheng, Shiguang Huang, Fangli Lu
Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Human and mouse mast cells (MCs) express the IL-27R. To explore the expressions of IL-27/IL-27R subunits (WSX-1 and gp130) during acute ocular toxoplasmosis (OT), we established mouse model by intraocular injection of 500 Toxoplasma gondii RH strain tachyzoites. Histopathological changes were analyzed, MCs were counted by toluidine blue staining, and tryptase+ /IL-27+ MCs were examined by immunofluorescence double-staining in the eyes and cervical lymph nodes (CLNs) of T...
May 19, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29770435/fetal-rotation-during-vacuum-extractions-for-prolonged-labour-a-prospective-cohort-study
#8
Birgitte Heiberg Kahrs, Sana Usman, Tullio Ghi, Aly Youssef, Erik Andreas Torkildsen, Elsa Lindtjørn, Tilde Borch Østborg, Sigurlaug Benediktsdottir, Lis Brooks, Lotte Harmsen, Kjell Åsmund Salvesen, Cristoph C Lees, Torbjørn Moe Eggebø
INTRODUCTION: The aim of the study was to investigate fetal head rotation during vacuum extraction. MATERIAL AND METHODS: We conducted a prospective cohort study from November 2013 to July 2016 in seven European hospitals. Fetal head position was determined with transabdominal or transperineal ultrasound and categorized as occiput anterior (OA), occiput transverse (OT) or occiput posterior (OP) position. Main outcome was the proportion of fetuses rotating during vacuum extraction...
May 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29770106/perceptions-about-authentic-leadership-development-south-african-occupational-therapy-students-camp-experience
#9
Fatima Hendricks, Susan Toth-Cohen
Background: Twenty-three years into democracy, concern is deepening regarding the slow progress of Occupational Therapy (OT) in South Africa, especially with regard to diversity and inclusion within OT. Methods: This study explores authentic leadership development primarily among Black OT students attending a pilot Occupational Therapy Association of South Africa (OTASA) National Student Leadership Camp. It seeks to ascertain their perceptions on leadership and leadership development...
2018: Occupational Therapy International
https://www.readbyqxmd.com/read/29767354/proprioceptive-muscle-tendon-stimulation-reduces-symptoms-in-primary-orthostatic-tremor
#10
M Wuehr, C Schlick, K Möhwald, R Schniepp
INTRODUCTION: Primary orthostatic tremor (OT) is characterized by high-frequency lower limb muscle contractions and a disabling sense of unsteadiness while standing. To date, therapeutic options for OT are limited. Here, we examined the effects of proprioceptive leg muscle stimulation via muscle tendon vibration (MTV) on tremor and balance control in patients with primary OT. METHODS: Tremor in nine patients with primary OT was examined during four conditions: standing (1), standing with MTV on the bilateral soleus muscles (2), lying (3), and lying with MTV (4)...
May 16, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29765330/glial-cells-are-involved-in-ang-ii-induced-vasopressin-release-and-sodium-intake-in-awake-rats
#11
Atalia F L Flôr, José L de Brito Alves, Maria S França-Silva, Camille M Balarini, Lucila L K Elias, Silvia G Ruginsk, José Antunes-Rodrigues, Valdir A Braga, Josiane C Cruz
It is known that circulating angiotensin II (ANG-II) acts on the circumventricular organs (CVOs), which partially lack a normal blood-brain barrier, to stimulate pressor responses, vasopressin (AVP), and oxytocin (OT) secretion, as well as sodium and water intake. Although ANG-II type 1 receptors (AT1R ) are expressed in neurons and astrocytes, the involvement of CVOs glial cells in the neuroendocrine, cardiovascular and behavioral responses induced by central ANG II remains to be further elucidated. To address this question, we performed a set of experiments combining in vitro studies in primary hypothalamic astrocyte cells (HACc) and in vivo intracerebroventricular (icv) microinjections into the lateral ventricle of awake rats...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29765082/pretreatment-drug-resistance-in-a-large-countrywide-ethiopian-hiv-1c-cohort-a-comparison-of-sanger-and-high-throughput-sequencing
#12
Nigus Fikrie Telele, Amare Worku Kalu, Solomon Gebre-Selassie, Daniel Fekade, Samir Abdurahman, Gaetano Marrone, Ujjwal Neogi, Belete Tegbaru, Anders Sönnerborg
Baseline plasma samples of 490 randomly selected antiretroviral therapy (ART) naïve patients from seven hospitals participating in the first nationwide Ethiopian HIV-1 cohort were analysed for surveillance drug resistance mutations (sDRM) by population based Sanger sequencing (PBSS). Also next generation sequencing (NGS) was used in a subset of 109 baseline samples of patients. Treatment outcome after 6- and 12-months was assessed by on-treatment (OT) and intention-to-treat (ITT) analyses. Transmitted drug resistance (TDR) was detected in 3...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763367/hsp70-protects-rats-and-hippocampal-neurons-from-central-nervous-system-oxygen-toxicity-by-suppression-of-no-production-and-nf-%C3%AE%C2%BAb-activation
#13
Hongjie Yi, Guoyang Huang, Kun Zhang, Shulin Liu, Weigang Xu
During diving, central nervous system oxygen toxicity may cause drowning or barotrauma, which has dramatically limited the working benefits of hyperbaric oxygen in underwater operations and clinical applications. The aim of this study is to understand the effects and the underlying mechanism of heat shock protein 70 on central nervous system oxygen toxicity and its mechanisms in vivo and in vitro. Rats were given geranylgeranylacetone (800 mg/kg) orally to induce hippocampal expression of heat shock protein 70 and then treated with hyperbaric oxygen...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29757599/native-alanine-substitution-in-the-glycine-hinge-modulates-conformational-flexibility-of-heme-nitric-oxide-oxygen-h-nox-sensing-proteins
#14
Charles W Hespen, Joel J Bruegger, Yirui Guo, Michael A Marletta
Heme nitric oxide/oxygen sensing (H-NOX) domains are direct NO sensors that regulate a variety of biological functions in both bacteria and eukaryotes. Previous work on H-NOX proteins has shown that upon NO binding, a conformational change occurs along two glycine residues on adjacent helices (termed the glycine hinge). Despite the apparent importance of the glycine hinge, it is not fully conserved in all H-NOX domains. Several H-NOX sensors from the family Flavobacteriaceae contain a native alanine substitution in one of the hinge residues...
May 14, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29756649/measuring-peripheral-oxytocin-and-vasopressin-in-nonhuman-primates
#15
REVIEW
Toni E Ziegler
Studying the neural and hormonal changes that modulate behavior is critical to understanding social relationships. Of particular interest is measuring oxytocin (OT) and arginine vasopressin (AVP) peripherally, and preferably, non-invasively, in nonhuman primates. Due to these peptides' neural origin and their stimulation of brain areas that influence social behavior, there has been debate whether peripheral measures in blood, urine, and saliva reflect central levels in the brain. This review elucidates the challenges of OT measurement and the solutions that provide valuable data on OT's role in social behavior...
May 14, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29750388/impact-of-ovarian-transposition-before-pelvic-irradiation-on-ovarian-function-among-long-term-survivors-of-childhood-hodgkin-lymphoma-a-report-from-the-st-jude-lifetime-cohort-study
#16
Israel Fernandez-Pineda, Andrew M Davidoff, Lu Lu, Bhaskar N Rao, Carmen L Wilson, D Kumar Srivastava, James L Klosky, Monica L Metzger, Matthew J Krasin, Kirsten K Ness, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Charles A Sklar, Daniel M Green, Wassim Chemaitilly
BACKGROUND: We reviewed the effect of ovarian transposition (OT) on ovarian function among long-term survivors of childhood Hodgkin lymphoma (HL) treated with pelvic radiotherapy. PROCEDURE: Female participants (age 18+ years) with HL in the St. Jude Lifetime Cohort Study (SJLIFE) were clinically evaluated for premature ovarian insufficiency (POI) 10 or more years after pelvic radiotherapy. Reproductive history including age at menopause and pregnancy/live births was available on all patients...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29743389/an-epidemic-of-bladder-cancer-ten-cases-of-bladder-cancer-in-male-japanese-workers-exposed-to-ortho-toluidine
#17
Makiko Nakano, Kazuyuki Omae, Toru Takebayashi, Shigeru Tanaka, And Shigeki Koda
BACKGROUND: ortho-Toluidine (OT) was listed as a Group 1 carcinogen by the International Agency for Research on Cancer in 2012 based on epidemiological observations of workers co-exposed to OT and aromatic amines. From 2014 to 2017, several cases of bladder cancer (BCa) secondary to occupational exposure, primarily to OT, were detected in Japan. OBJECTIVE: To describe 10 cases of BCa in male Japanese workers exposed primarily to OT at two plants that produce organic dye and pigment intermediates...
May 9, 2018: Journal of Occupational Health
https://www.readbyqxmd.com/read/29742869/serologic-tests-of-igg-and-igm-antibodies-and-igg-avidity-for-diagnosis-of-ocular-toxoplasmosis
#18
Bahman Rahimi-Esboei, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Raziyeh Mahmoudzadeh, Mirataollah Salabati
This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti- Toxoplasma gondii IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included in this study. Of the patients, 77 cases were positive for anti- T. gondii IgG, and 8 cases were positive for anti- T. gondii IgM. IgG avidity test revealed 11, 4, and 102 cases were low, intermediate, and high, respectively, and 6...
April 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29740287/inhibition-of-glur-current-in-microvilli-of-sensory-neurons-via-na-microdomain-coupling-among-glur-hcn-channel-and-na-k-pump
#19
Yasuhiro Kawasaki, Mitsuru Saito, Jonghwa Won, Jin Young Bae, Hajime Sato, Hiroki Toyoda, Eriko Kuramoto, Mikihiko Kogo, Takuma Tanaka, Takeshi Kaneko, Seog Bae Oh, Yong Chul Bae, Youngnam Kang
Glutamatergic dendritic EPSPs evoked in cortical pyramidal neurons are depressed by activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels expressed in dendritic spines. This depression has been attributed to shunting effects of HCN current ( I h ) on input resistance or I h deactivation. Primary sensory neurons in the rat mesencephalic trigeminal nucleus (MTN) have the somata covered by spine-like microvilli that express HCN channels. In rat MTN neurons, we demonstrated that I h enhancement apparently diminished the glutamate receptor (GluR) current ( I GluR ) evoked by puff application of glutamate/AMPA and enhanced a transient outward current following I GluR (OT- I GluR )...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29739257/obtuse-triangle-screw-configuration-for-optimal-internal-fixation-of-femoral-neck-fracture-an-anatomical-analysis
#20
Qiuliang Zhu, Bengong Shi, Bin Xu, Jianfeng Yuan
OBJECTIVES: To identify the optimal screw configuration for internal fixation of femoral neck fractures based on anatomic analysis on radiologic imaging. METHODS: Thirty proximal femurs of 15 adults were constructed by CT. Three femoral neck sections (FNS), the subcapital, medial, and the fundus, were projected on the lateral femoral trochanteric wall. The simulated three screw configurations in the projection of FNS include: two inverted equilateral triangles symmetrized to the axis of the FNS (IET-FNS group) or the coronal axis of the proximal femur (IET-PR group) and an obtuse triangle (OT group)...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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