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https://www.readbyqxmd.com/read/28812274/oxytocin-and-anxiety-disorders
#1
Michael G Gottschalk, Katharina Domschke
In the present chapter, we review the literature focusing on oxytocin (OT)-centered research in anxiety spectrum conditions, comprising separation anxiety disorder, specific phobias, social anxiety disorder (SAD), panic disorder, generalized anxiety disorder, and anxiety-related endophenotypes (e.g., trust behavior, behavioral inhibition, neuroticism, and state/trait anxiety). OT receptor gene (OXTR) polymorphisms have been implicated in gene-environment interactions with attachment style and childhood maltreatment and to influence clinical outcomes, including SAD intensity and limbic responsiveness...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812271/oxytocin-and-interpersonal-relationships
#2
Alexandra Patin, Dirk Scheele, Rene Hurlemann
The neuropeptide oxytocin (OT) has emerged as a potent modulator of diverse aspects of interpersonal relationships. OT appears to work in close interaction with several other neurotransmitter networks, including the dopaminergic reward circuit, and to be dependent on sex-specific hormonal influences. In this chapter, we focus on four main domains of OT and interpersonal relationships, including (1) the protective effect of OT on an individual's ability to withstand stress (i.e., stress buffering), (2) the effect of OT on emotion recognition and empathy, (3) OT's ability to enhance social synchrony and cooperation among individuals, and (4) the effect of OT on an individual's perception of social touch...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812267/oxytocin-and-parental-behaviors
#3
Chihiro Yoshihara, Michael Numan, Kumi O Kuroda
The oxytocin/vasopressin ancestor molecule has been regulating reproductive and social behaviors for more than 500 million years. In all mammals, oxytocin is the hormone indispensable for milk-ejection during nursing (maternal milk provision to offspring), a process that is crucial for successful mammalian parental care. In laboratory mice, a remarkable transcriptional activation occurs during parental behavior within the anterior commissural nucleus (AC), the largest magnocellular oxytocin cell population within the medial preoptic area (although the transcriptional activation was limited to non-oxytocinergic neurons in the AC)...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812266/oxytocin-and-social-relationships-from-attachment-to-bond-disruption
#4
Oliver J Bosch, Larry J Young
Social relationships throughout life are vital for well-being and physical and mental health. A significant amount of research in animal models as well as in humans suggests that oxytocin (OT) plays an important role in the development of the capacity to form social bonds, the mediation of the positive aspects of early-life nurturing on adult bonding capacity, and the maintenance of social bonding. Here, we focus on the extensive research on a socially monogamous rodent model organism, the prairie vole (Microtus ochrogaster)...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28812263/molecular-basis-of-oxytocin-receptor-signalling-in-the-brain-what-we-know-and-what-we-need-to-know
#5
Marta Busnelli, Bice Chini
Oxytocin (OT), a hypothalamic neuropeptide involved in regulating the social behaviour of all vertebrates, has been proposed as a treatment for a number of neuropsychiatric disorders characterised by deficits in the social domain. Over the last few decades, advances focused on understanding the social effects of OT and its role in physiological conditions and brain diseases, but much less has been done to clarify the molecular cascade of events involved in mediating such effects and in particular the cellular and molecular pharmacology of OT and its target receptor (OTR) in neuronal and glial cells...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28811960/rehmannia-glutinosa-polysaccharide-induces-toll-like-receptor-4-dependent-spleen-dendritic-cell-maturation-and-anti-cancer-immunity
#6
Li Xu, Minseok Kwak, Wei Zhang, Ling Zeng, Peter Chang-Whan Lee, Jun-O Jin
Rehmannia glutinosa polysaccharide (RGP) has shown an activation of immune cells in vitro. However, the immune stimulatory effect of RGP in a mouse in vivo is not well studied. In this study, we examined the effect of RGP on dendritic cell (DC) activation and anticancer immunity in vivo. Treatments of RGP in C56BL/6 mice induced increased levels of co-stimulatory molecule expression and pro-inflammatory cytokine production in spleen DCs dependent on toll-like receptor 4 (TLR4), and those DCs promoted interferon-gamma (IFNγ) production in CD4(+) and CD8(+) T cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28807693/safety-and-feasibility-of-rehabilitation-interventions-in-children-undergoing-hematopoietic-stem-cell-transplant-with-thrombocytopenia
#7
Katarzyna Ibanez, Noel Espiritu, Regine L Souverain, Laura Stimler, Lauren Ward, Elyn R Riedel, Rachel Lehrman, Farid Boulad, Michael Dean Stubblefield
OBJECTIVE: To analyze the relationship between platelet counts, the intensities of physical therapies (PT) and occupational therapies (OT) services received, and the frequency of bleeding complications in children undergoing hematopoietic stem cell transplants (HSCT) during a period of severe thrombocytopenia. DESIGN: Retrospective review study SETTING: Tertiary care hospital PARTICIPANTS: Children (age <18) hospitalized for HSCT in 2010 and 2011 who received PT and OT services while markedly thrombocytopenic (platelets≤50K/mcL)...
August 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28805568/complementary-and-alternative-medicine-and-exercise-in-nonmotor-symptoms-of-parkinson-s-disease
#8
Indu Subramanian
The use of complementary and alternative medicine (CAM) therapy in nonmotor symptoms (NMS) for Parkinson disease (PD) is growing worldwide. Well-performed, systematic evidence-based research is largely lacking in this area and many studies include various forms of CAM with small patient numbers and a lack of standardization of the approaches studied. Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep and PDQ39; dance in cognition, apathy, and a mild trend to improved fatigue; yoga in PDQ39; and acupuncture in depression, PDQ39, and sleep...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28804450/whole-brain-mapping-of-the-inputs-and-outputs-of-the-medial-part-of-the-olfactory-tubercle
#9
Zhijian Zhang, Hongruo Zhang, Pengjie Wen, Xutao Zhu, Li Wang, Qing Liu, Jie Wang, Xiaobin He, Huadong Wang, Fuqiang Xu
The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still unclear. In the present study, the medial part of the OT was found to be highly connected with a wide range of brain areas with the help of the pseudorabies virus tracing tool. In order to further investigate the detailed connections for specific neurons, another tracing tool - rabies virus was utilized for D1R-cre and D2R-cre mice...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28802996/il-33-matured-dendritic-cells-promote-th17-cell-responses-via-il-1%C3%AE-and-il-6
#10
Su-Ho Park, Myun Soo Kim, Hui Xuan Lim, Daeho Cho, Tae Sung Kim
IL-33 is associated with a variety of autoimmune diseases, such as sclerosis, inflammatory bowel disease, and rheumatoid arthritis. Although IL-33 is mainly involved in the induction of Th2 cells, however, the relationship between IL-33 and Th17 cells is still largely unknown. In this study, we investigated the effects of IL-33 on DC-mediated CD4(+) T cell activation and Th17 cell differentiation because DCs are essential cells for presenting self-antigens to CD4(+) T cells in autoimmune disease conditions...
August 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28801975/trends-in-aging-related-services-during-nephrectomy-implications-for-surgery-in-an-aging-population
#11
Hung-Jui Tan, Mark S Litwin, Karim Chamie, Debra Saliba, Jim C Hu
OBJECTIVES: To characterize the extent to which geriatric and related healthcare services are provided to older adults undergoing surgery for kidney cancer, a potential growth area in geriatrics and oncology. DESIGN: Population-based observational study. SETTING: Surveillance, Epidemiology, and End Results cancer data linked with Medicare claims. PARTICIPANTS: Adults aged 65 and older with kidney cancer treated surgically from 2000 to 2009 (N = 19,129)...
August 11, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28801574/intestinal-transepithelial-permeability-of-oxytocin-into-the-blood-is-dependent-on-the-receptor-for-advanced-glycation-end-products-in-mice
#12
Haruhiro Higashida, Kazumi Furuhara, Agnes-Mikiko Yamauchi, Kisaburo Deguchi, Ai Harashima, Seiichi Munesue, Olga Lopatina, Maria Gerasimenko, Alla B Salmina, Jia-Sheng Zhang, Hikari Kodama, Hironori Kuroda, Chiharu Tsuji, Satoshi Suto, Hiroshi Yamamoto, Yasuhiko Yamamoto
Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother's milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1-7 mice. However, in Receptors for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT increase was not observed...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800198/identification-of-crystalline-orientation-of-black-phosphorus-by-optothermal-raman-spectroscopy
#13
Xinwei Wang, Tianyu Wang, Jing Liu, Biao Xu, Ridong Wang, Pengyu Yuan, Meng Han, Shen Xu, Yangsu Xie, Yue Wu
Current polarized Raman-based techniques for identifying the crystalline orientation of black phosphorus suffer big uncertainty and unreliability because of the complex interference involving excitation laser wavelength, scattering light wavelength, and sample thickness. Here, for the first time, we present a new optothermal Raman spectroscopy (OT-Raman) for identifying crystalline orientation. With a physical mechanism based on the anisotropic optical absorption of polarized laser and the resulting heating, the OT-Raman can identify the crystalline orientation explicitly regardless of excitation wavelength and sample thickness by Raman frequency-power differential Φ (=∂ω/∂P)...
August 11, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28799371/a-computational-component-analysis-of-dielectric-relaxation-and-thz-spectra-of-water-aot-reverse-micelles-with-different-water-loading
#14
Michael Schmollngruber, Daniel Braun, Othmar Steinhauser
In this computational study, we present molecular dynamics simulations of water/aerosol-OT/isooctane reverse micelles with different water loading. We compare these systems in terms of a detailed analysis of dielectric relaxation spectra and water librations in the THz region. The spectra are decomposed into contributions by molecular species and contributions from individual water solvation shells. Additionally, micellar tumbling motion is shown to have a profound influence on the observed dielectric relaxation spectra, if relaxation by internal reorganization and micellar tumbling occurs within similar time scales...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28799022/early-vs-standard-unclamping-technique-in-minimal-access-partial-nephrectomy-a-meta-analysis-of-observational-cohort-studies-and-the-lister-cohort
#15
REVIEW
Thomas Stonier, Bhavan Prasad Rai, Mariele Trimboli, Ahmed Abroaf, Amit Patel, S Gowrie-Mohan, Venkat Prasad, Nikhil Vasdev, Jim Adshead
To evaluate if early unclamping (EUC) of the renal pedicle compromises perioperative outcomes in minimally invasive partial nephrectomy (PN). The cohort study includes all robot-assisted PN performed between September 2012 and September 2015 by a single surgeon at the Lister Hospital, Stevenage, UK. The systematic review and meta-analysis was performed according to the PRISMA guidelines identifying studies comparing EUC and standard unclamping (SUC) in either laparoscopic or robot-assisted PN. The Lister cohort prospectively reported 84 cases of robot-assisted PN (SUC = 22, EUC = 62) with a mean age of 58 years (SD = 11)...
August 10, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28798724/vasopressin-and-oxytocin-reduce-food-sharing-behavior-in-male-but-not-female-marmosets-in-family-groups
#16
Jack H Taylor, Allison A Intorre, Jeffrey A French
Oxytocin (OT) is critical for lactation and maternal care, but OT and the related nonapeptide vasopressin are important for caregiving behaviors in fathers and alloparents as well. This experiment tested the effects of vasopressin and OT on food sharing in marmoset families. We treated caregivers (parents, siblings) with intranasal vasopressin, OT, or saline, and then paired them with the youngest marmoset in the family. Caregivers were given preferred food, and then observed for food sharing and aggressive behavior with young marmosets...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28793846/health-literacy-and-written-communication-in-skilled-nursing-subacute-facilities
#17
Christopher Galati, Rachel Adams, Kay Graham, Katharyn Reynolds, Julia Zametin
Health literacy is a concern for older adults. Low health literacy can lead to adverse health outcomes; therefore, practitioners should address health literacy with clients. There is limited research addressing occupational therapy (OT) practitioners' knowledge of health literacy and its implementation in written communication in skilled nursing facility (SNF)/subacute settings. Researchers explored practitioners' knowledge and current practices when using written communication with older adult clients in skilled nursing and subacute settings...
August 1, 2017: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/28793827/kiwi-omnicup-handheld-vs-mityvac-m-style-conventional-vacuum-system-a-retrospective-observational-study
#18
Tal Weissbach, Nasreen Hag-Yahia, Michal Ovadia, Keren Tzadikevitch Geffen, Omer Weitzner, Tal Biron-Shental
INTRODUCTION: To improve choice of vacuum-assisted delivery (VAD) system, we compared outcomes of Kiwi handheld system and Mityvac M-style conventional system (both use disposable plastic cups). MATERIALS AND METHODS: Retrospective observational study with data collection from electronic medical records. The study was conducted at a tertiary medical center, with approximately 7000 deliveries annually. Categorical and continuous variables were analyzed using chi-square test and t-test, respectively...
August 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28790980/exploring-microdiversity-in-novel-kordia-sp-bacteroidetes-with-proteorhodopsin-from-the-tropical-indian-ocean-via-single-amplified-genomes
#19
Marta Royo-Llonch, Isabel Ferrera, Francisco M Cornejo-Castillo, Pablo Sánchez, Guillem Salazar, Ramunas Stepanauskas, José M González, Michael E Sieracki, Sabrina Speich, Lars Stemmann, Carlos Pedrós-Alió, Silvia G Acinas
Marine Bacteroidetes constitute a very abundant bacterioplankton group in the oceans that plays a key role in recycling particulate organic matter and includes several photoheterotrophic members containing proteorhodopsin. Relatively few marine Bacteroidetes species have been described and, moreover, they correspond to cultured isolates, which in most cases do not represent the actual abundant or ecologically relevant microorganisms in the natural environment. In this study, we explored the microdiversity of 98 Single Amplified Genomes (SAGs) retrieved from the surface waters of the underexplored North Indian Ocean, whose most closely related isolate is Kordia algicida OT-1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28783266/complications-after-prone-pcnl-in-pediatric-adult-and-geriatric-patients-a-single-center-experience-over-7-years
#20
Sumit Kumar, Ramaiah Keshavamurthy, Vilvapathy Senguttuvan Karthikeyan, Ashwin Mallya
INTRODUCTION: CROES-Clavien system (CCS) for grading complications in percutaneous nephrolithotomy (PCNL) is a step towards standardization of outcomes. We categorized complications based on CCS and predicted risk factors across the entire cohort and individually for pediatric (P: ≤18 years), adult (A: 19-65 years) and geriatric (G: ≥65 years) subgroups to assess the risk factors in each subset. We assessed association of complications with length of hospitalization (LOH) and operation time (OT)...
July 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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