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https://www.readbyqxmd.com/read/28098059/laparoscopic-ileocecal-resection-in-acute-and-chronic-presentations-of-crohn-s-disease-a-single-center-experience
#1
G Cocorullo, R Tutino, N Falco, G Salamone, T Fontana, L Licari, G Gulotta
INTRODUCTION: The terminal ileum is the most involved tract in Crohn's disease. The obstruction in this location is the most frequent complication. Acute or chronic presentations can occur. Surgery finds a role in the management of chronic strictures and in acute clinical presentations with complications not improving with conservative therapy. PATIENTS AND METHODS: We investigate the outcome of patients with obstruction of the ileo-cecal bowel tract laparoscopically managed...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28092139/content-of-conventional-therapy-for-the-severely-affected-arm-during-subacute-rehabilitation-after-stroke-an-analysis-of-physiotherapy-and-occupational-therapy-practice
#2
Lex D de Jong, Frederike van Wijck, Roy E Stewart, Alexander C H Geurts, Pieter U Dijkstra
BACKGROUND AND PURPOSE: Physiotherapy (PT) and occupational therapy (OT) are key professions providing treatment for the arm after stroke; however, knowledge about the content of these treatments is scant. Detailed data are needed to replicate interventions, evaluate their effective components, and evaluate PT and OT practice. This paper describes PT and OT treatment for the severely affected arm in terms of duration, content according to components and categories of the International Classification of Human Functioning, Disability and Health, and to analyze differences between professions...
January 16, 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/28086810/genotypic-characterization-of-orientia-tsutsugamushi-from-patients-in-two-geographical-locations-in-sri-lanka
#3
Ranjan Premaratna, Lucas S Blanton, Dilhar N Samaraweera, G Nalika N de Silva, Nilmini T G A Chandrasena, David H Walker, H J de Silva
BACKGROUND: To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to establish effective diagnostics, clinical management and to develop effective vaccines. Genetic and antigenic characterization of OT causing human disease in OT-endemic regions is not known for Sri Lanka...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28077439/the-functional-expression-of-transient-receptor-potential-channels-in-the-mouse-endometrium
#4
Katrien De Clercq, Charlotte Van den Eynde, Aurélie Hennes, Rieta Van Bree, Thomas Voets, Joris Vriens
STUDY QUESTION: Does mouse endometrial epithelial cells and stromal cells have a similar transient receptor potential (TRP)-channel expression profile and to that found in the human endometrium? SUMMARY ANSWER: Mouse endometrial epithelial and stromal cells have a distinct TRP channel expression profile analogous to what has been found in human endometrium, and hence suggests the mouse a good model to investigate the role of TRP channels in reproduction. WHAT IS KNOWN ALREADY: An optimal intercellular communication between epithelial and stromal endometrial cells is crucial for successful reproduction...
January 6, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28072615/retinal-detachment-associated-with-peripapillary-staphyloma-imaged-with-swept-source-optical-coherence-tomography
#5
Daisuke Kunita, Makoto Inoue, Takashi Koto, Akito Hirakata
PURPOSE: To examine a rhegmatogenous retinal detachment (RRD) associated with a peripapillary staphyloma with swept source optical coherence tomography (SS-OCT) before and after vitrectomy and circumferential photocoagulation. METHODS: The SS-OCT images including the montage images of two patients with a RRD associated with peripapillary staphylomas were analyzed. A 34-year-old woman (Case 1) and a 70-year-old woman (Case 2) both noticed temporal visual field defects in their left eyes...
January 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28059521/conformational-entropy-from-nmr-relaxation-in-proteins-the-srls-perspective
#6
Oren Tchaicheeyan, Eva Meirovitch
Conformational entropy changes associated with bond-vector motions in proteins contribute to the free energy of ligand binding. To derive such contributions we apply the slowly relaxing local structure (SRLS) approach to NMR relaxation from (15)N-H bonds or C-CDH2 moieties of several proteins in free and ligand-bound form. The spatial restraints on probe motion, which determine the extent of local order, are expressed in SRLS by a potential, u(θ). The latter yields the orientational probability density, Peq = exp(-u(θ)), hence the related conformational entropy, Š=-∫Peq(θ) ln⁡[Peq(<it>θ</it>)]sin<it>⁡θ</it> d<it>θ</it> (Š is "entropy" in units of kBT, and θ represents the bond-vector orientation in the protein)...
January 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28052452/oxytocin-response-to-youth-mother-interactions-in-clinically-anxious-youth-is-associated-with-separation-anxiety-and-dyadic-behavior
#7
Eli R Lebowitz, Wendy K Silverman, Alyssa M Martino, Orna Zagoory-Sharon, Ruth Feldman, James F Leckman
BACKGROUND: Anxiety disorders are common in youth and cause significant distress and impairment to the individual and family. Oxytocin (OT), a nine amino acid peptide, is implicated in anxiety regulation and modulation of close interpersonal and attachment behavior. Anxiety disorders have been linked to low levels of salivary OT in youth. Research has also linked oxytocinergic functioning to social support, warm contact, and bonding, and indicated that contact with attachment figures stimulates OT response...
January 3, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28049625/regulation-of-the-macrophage-oxytocin-receptor-in-response-to-inflammation
#8
Angela Szeto, Ni Sun-Suslow, Armando J Mendez, Rosa I Hernandez, Klaus V Wagner, Philip M McCabe
It has been demonstrated that the neuropeptide oxytocin (OT) attenuates oxidative stress and inflammation in macrophages. In the current study, we examined the role of inflammation on the expression of the oxytocin receptor (OXTR). We hypothesized that OXTR expression is increased during the inflammation though a nuclear factor kappa B (NF-κB) mediated pathway, thus responding as an acute phase protein. Inflammation was induced by treating macrophages (human primary, THP-1, and murine) with lipopolysaccharide (LPS) and monitored by expression of IL-6...
January 3, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28049505/surgical-intervention-for-vertebral-metastases-may-benefit-lung-cancer-patients-no-less-than-other-patients-a-retrospective-study
#9
Takashi Kobayashi, Naohisa Miyakoshi, Toshiki Abe, Eiji Abe, Kazuma Kikuchi, Yoichi Shimada, Seiko Matsumoto, Shin Fukui
BACKGROUND: Spinal metastasis is considered to have a worse prognosis in lung cancer than in other cancers, but recent clinical studies report improved overall survival of lung cancer. We compared the postoperative prognoses of vertebral metastatic tumors from lung with other types of cancer. METHODS: From 2011 to 2015, 31 Japanese patients (mean age 73 years, range 55-88 years; 19 males, 12 females) underwent surgery for spinal metastasis at our center. We observed patients retrospectively in March 2016, dividing them into groups by cancer type: lung (LK group, n = 10); prostate, breast, or thyroid (PB group, n = 12); and other (OT group, n = 9)...
January 4, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28049501/the-abnormal-expression-of-oxytocin-receptors-in-the-uterine-junctional-zone-in-women-with-endometriosis
#10
Miaomaio Huang, Xuqing Li, Peipei Guo, Zhaojuan Yu, Yuting Xu, Zhaolian Wei
BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis...
January 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28049480/effectiveness-of-sensor-monitoring-in-an-occupational-therapy-rehabilitation-program-for-older-individuals-after-hip-fracture-the-so-hip-trial-study-protocol-of-a-three-arm-stepped-wedge-cluster-randomized-trial
#11
Margriet C Pol, Gerben Ter Riet, Margo van Hartingsveldt, Ben Kröse, Sophia E de Rooij, Bianca M Buurman
BACKGROUND: The performance of activities of daily living (ADL) at home is important for the recovery of older individuals after hip fracture. However, 20-90% of these individuals lose ADL function and never fully recover. It is currently unknown to what extent occupational therapy (OT) with coaching based on cognitive behavioral treatment (CBT) improves recovery. The same holds for sensor monitoring-based coaching in addition to OT. Here, we describe the design of a study investigating the effect of sensor monitoring embedded in an OT rehabilitation program on the recovery of ADL among older individuals after hip fracture...
January 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28049009/oxytocin-system-dysfunction-as-a-common-mechanism-underlying-metabolic-syndrome-and-psychiatric-symptoms-in-schizophrenia-and-bipolar-disorders
#12
REVIEW
Daniel S Quintana, Ingrid Dieset, Torbjørn Elvsåshagen, Lars T Westlye, Ole A Andreassen
There is growing interest in using intranasal oxytocin (OT) to treat social dysfunction in schizophrenia and bipolar disorders (i.e., psychotic disorders). While OT treatment results have been mixed, emerging evidence suggests that OT system dysfunction may also play a role in the aetiology of metabolic syndrome (MetS), which appears in one-third of individuals with psychotic disorders and associated with increased mortality. Here we examine the evidence for a potential role of the OT system in the shared risk for MetS and psychotic disorders, and its prospects for ameliorating MetS...
December 31, 2016: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28045457/endemicity-of-the-cosmopolitan-mesophilic-chemolithoautotroph-sulfurimonas-at-deep-sea-hydrothermal-vents
#13
Sayaka Mino, Satoshi Nakagawa, Hiroko Makita, Tomohiro Toki, Junichi Miyazaki, Stefan M Sievert, Martin F Polz, Fumio Inagaki, Anne Godfroy, Shingo Kato, Hiromi Watanabe, Takuro Nunoura, Koichi Nakamura, Hiroyuki Imachi, Tomo-O Watsuji, Shigeaki Kojima, Ken Takai, Tomoo Sawabe
Rich animal and microbial communities have been found at deep-sea hydrothermal vents. Although the biogeography of vent macrofauna is well understood, the corresponding knowledge about vent microbial biogeography is lacking. Here, we apply the multilocus sequence analysis (MLSA) to assess the genetic variation of 109 Sulfurimonas strains with ⩾98% 16S rRNA gene sequence similarity, which were isolated from four different geographical regions (Okinawa Trough (OT), Mariana Volcanic Arc and Trough (MVAT), Central Indian Ridge (CIR) and Mid-Atlantic Ridge (MAR))...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28043721/effect-of-daily-use-of-electronic-checklist-on-physical-rehabilitation-consultations-in-critically-ill-patients
#14
Rashid Ali, Patrick J Cornelius, Vitaly Herasevich, Ognjen Gajic, Rahul Kashyap
RATIONALE: In intensive care unit (ICU) practice, great emphasis is placed on the functional stabilization of the major organ systems, sometimes at the expense of physical rehabilitation. Checklists have shown to be an effective tool for standardizing care models. Our aim was to the study the effect of the use of an electronic checklist on occupational therapy/physical therapy (OT-PT) consults in critically ill patients. METHODS: A retrospective observational study of all adults admitted for the first time in an academic medical ICU in year 2014 was conducted...
December 22, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28043376/disorders-in-barrier-protein-mrna-expression-and-placenta-secretory-activity-under-the-influence-of-polychlorinated-biphenyls-in%C3%A2-vitro
#15
A Wojciechowska, J Mlynarczuk, J Kotwica
Pregnancy disorders are often correlated with the presence of organic pollutants in the tissues of living bodies. The aim of this study was to investigate the effects (over 24 and 48 hours) of polychlorinated biphenyls (PCBs) 153, 126, and 77 at doses of 1, 10, and 100 ng/mL on barrier function and secretory activity in cow placentome sections collected during the second trimester of pregnancy. None of the PCBs affected the viability of the sections (P > 0.05). Polychlorinated biphenyl 153 decreased (P < 0...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28033163/a-retrospective-comparison-of-home-telehealth-and-nursing-care-with-or-without-rehabilitation-therapy-on-rehospitalization-rates-of-individuals-with-heart-failure
#16
Stacy Martin, Bill Anderson, Jennifer L Vincenzo, Sajid Yousuf Zai
PURPOSE: Congestive heart failure (CHF) is the most common reason for rehospitalization among the aging population, accounting for one-fifth of all hospital admissions. To date, there is no research comparing the rehospitalization rates between patients with CHF (PWCHF) who receive telehealth and home health nursing care versus a multidisciplinary team consisting of telehealth, home nursing, physical therapy (PT), and/or occupational therapy (OT). METHODS: A retrospective analysis was performed with 132 Medicare Part A home health patients discharged from an inpatient setting with a primary or secondary diagnosis of CHF receiving daily telehealth over the course of 1 year...
December 28, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28030587/cd5-ck2-signaling-modulates-erk-activation-and-thymocyte-survival
#17
Carlos A Mier-Aguilar, Kevin S Cashman, Chander Raman, Gloria Soldevila
CD5 is well recognized for its importance in thymic selection. Although this property of CD5 has been attributed to its ITIM-domain dependent regulation of TCR-signal strength, the mechanism has not been established. A second major signaling domain within the cytoplasmic tail of CD5 is a CK2 binding/activation domain (CD5-CK2BD). Using a gene-targeted mouse in which the CD5-CK2BD is selectively ablated (CD5-ΔCK2BD), we determined that loss of function of CD5-CK2 signaling in a MHC-II selecting TCR transgenic (OT-II) mouse resulted in decrease in double positive (DP) thymocytes, which correlated with enhanced apoptosis...
2016: PloS One
https://www.readbyqxmd.com/read/28027955/oxytocin-pathways-in-the-intergenerational-transmission-of-maternal-early-life-stress
#18
REVIEW
Philipp Toepfer, Christine Heim, Sonja Entringer, Elisabeth Binder, Pathik Wadhwa, Claudia Buss
Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions...
December 24, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28026700/how-are-canadian-universities-training-and-supporting-undergraduate-medical-physiotherapy-and-occupational-therapy-students-for-global-health-experiences-in-international-low-resource-settings
#19
Jennifer Bessette, Chantal Camden
OBJECTIVES: Canadian medical (MD), physiotherapy (PT) and occupational therapy (OT) students increasingly show an interest in global health experiences (GHEs). As certain moral hazards can occur as a result of student GHEs, a growing consensus exists that universities must have an established selection process, in-depth pre-departure training (PDT), adequate onsite supervision and formal debriefing for their students. This study aimed to identify current practices in Canadian MD, PT and OT programs and discuss areas for improvement by comparing them with recommendations found in the literature...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28026101/single-molecule-force-spectroscopy-trajectories-of-a-single-protein-and-its-polyproteins-are-equivalent-a-direct-experimental-validation-based-on-a-small-protein-nug2
#20
Hai Lei, Chengzhi He, Chunguang Hu, Jinliang Li, Xiaodong Hu, Xiaotang Hu, Hongbin Li
Single-molecule force spectroscopy (SMFS) has become a powerful tool in investigating the mechanical unfolding/folding of proteins at the single-molecule level. Polyproteins made of tandem identical repeats have been widely used in atomic force microscopy (AFM)-based SMFS studies, where polyproteins not only serve as fingerprints to identify single-molecule stretching events, but may also improve statistics of data collection. However, the inherent assumption of such experiments is that all the domains in the polyprotein are equivalent and one SMFS trajectory of stretching a polyprotein made of n domains is equivalent to n trajectories of stretching a single domain...
December 27, 2016: Angewandte Chemie
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