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https://www.readbyqxmd.com/read/28329892/ocular-toxoplasmosis-therapy-related-adverse-drug-reactions-and-their-management
#1
M Helfenstein, S Zweifel, D Barthelmes, F Meier, J Fehr, C Böni
Background There are different treatment options for ocular toxoplasmosis (OT). "Classic" therapy consists of pyrimethamine, sulfadiazine and folinic acid combined with systemic steroids and is still widely used. However, potentially severe side effects of this therapy have been reported. The aim of this retrospective study was to evaluate the incidence and types of adverse drug reactions in patients treated for OT. Clinical management of each adverse drug reaction was assessed. Patients and Methods In this retrospective analysis, we reviewed data of patients with OT, who were consecutively examined between December 2011 and December 2015 at the Department of Ophthalmology, University Hospital Zurich...
March 22, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28325799/a-proposal-for-an-out-of-range-glycemic-population-health-safety-measure-for-older-adults-with-diabetes
#2
Leonard Pogach, Chin-Lin Tseng, Orysya Soroka, Miriam Maney, David Aron
OBJECTIVE: To evaluate patient-level glycemic control and facility variation of a proposed out-of-range (OOR) measure (overtreatment [OT] [HbA1c <7% (53 mmol/mol)] or undertreatment [UT] [>9% (75 mmol/mol)]) compared with the standard measure (SM) (HbA1c <8% [64 mmol/mol]) in high-risk older adults. RESEARCH DESIGN AND METHODS: Veterans Health Administration patients ≥65 years of age in 2012 who were taking antihyperglycemic agents in 2013 were identified...
April 2017: Diabetes Care
https://www.readbyqxmd.com/read/28324706/combining-oxytocin-administration-and-positive-emotion-inductions-examining-social-perception-and-analytical-performance
#3
Lauren J Human, Katherine R Thorson, Joshua D Woolley, Wendy Berry Mendes
Intranasal administration of the hypothalamic neuropeptide oxytocin (OT) has, in some studies, been associated with positive effects on social perception and cognition. Similarly, positive emotion inductions can improve a range of perceptual and performance-based behaviors. In this exploratory study, we examined how OT administration and positive emotion inductions interact in their associations with social and analytical performance. Participants (N=124) were randomly assigned to receive an intranasal spray of OT (40IU) or placebo and then viewed one of three videos designed to engender one of the following emotion states: social warmth, pride, or an affectively neutral state...
March 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28323386/the-association-of-maternal-lymphatic-markers-and-critical-congenital-heart-defects-in-the-fetus-a-population-based-case-control-study
#4
Martina A Steurer, Mary E Norton, Rebecca J Baer, Gary M Shaw, Sheila Keating, Anita J Moon-Grady, Christina D Chambers, Laura L Jelliffe-Pawlowski
The objective ot this study was to investigate whether lymphatic markers measured in women during the second trimester are associated with critical congenital heart defects (CCHDs) in offspring. This is a retrospective cohort study of pregnant women who participated in the California Prenatal Screening Program. CCHD data in the offspring was captured by linking birth certificate data with hospital patient discharge records. Second trimester samples were assayed for vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) AA/BB, and PDGF AB...
March 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28322748/oxytocin-promotes-attention-to-social-cues-regardless-of-group-membership
#5
Michaela Pfundmair, Clarissa Zwarg, Markus Paulus, Anne Rimpel
The social saliency account proposes that oxytocin (OT) plays a major role in modulating attentional shifts toward social cues at early stages of processing. We investigated how OT promotes early attention toward nonsocial and social stimuli and explored differences between in-group- and out-group-related social cues. After participants intranasally self-administered OT or placebo, they were eye-tracked while observing a nonsocial and social cues that were assigned to the in- or out-group by a minimal group paradigm...
March 18, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28317931/recruitment-of-bone-marrow-cd11b-gr-1-cells-by-polymeric-nanoparticles-for-antigen-cross-presentation
#6
Ya-Wun Yang, Wen-Hui Luo
The objective of this study was to investigate the function of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) on the activation of antigen-specific CD8(+) T cell responses via the CD11b(+)Gr(-)1(+) myeloid subpopulations in murine bone marrow (BM). PLGA NPs containing ovalbumin (OVA) were fabricated by the double-emulsion method. The CD11b(+)Gr-1(low)Ly-6C(high) and CD11b(+)Gr-1(high)Ly-6C(low) subsets from mice bone marrow were sorted and treated with the PLGA/OVA NPs, followed by co-culture with the carboxyfluorescein succinimidyl ester (CFSE)-labelled OT-I CD8(+) cells...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317346/-efficacy-of-systemic-administration-of-oxytocin-on-implant-osseointegration-in-osteoporotic-rats
#7
Wang Maiquan, Peng Liwei, Li Yunfeng
OBJECTIVE: This study investigated the effects of systemic administration of oxytocin (OT) in osteoporotic rats on implant osseointegration. METHODS: Twenty rats were randomly assigned to the control and experimental groups. Initially, the rats underwent bilateral ovariectomy. After 12 weeks, an osteoporosis model was established. Each rat received an implant at the distal and middle femoral metaphysis. Simultaneously, systemic administration was conducted with one group receiving subcutaneous injection of OT (1 mg·kg⁻¹ per day), whereas the other group received placebo injection...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28301853/chronic-mesenteric-ischemia-patient-outcomes-using-open-surgical-revascularization
#8
Markus U Wagenhäuser, Yvonne K Meyer-Janiszewski, Philip Dueppers, Joshua M Spin, Nikolaos Floros, Hubert Schelzig, Mansur Duran
BACKGROUND: Chronic mesenteric ischemia (CMI) is a rare disease. Open treatment (OT) remains a valuable treatment option. We analyzed patient outcomes after OT and investigated health-related quality of life (HRQoL). METHODS: Data were analyzed retrospectively. The investigation period was from January 1, 2001, to December 31, 2014. We investigated mortality and patency rates using Kaplan-Meier analysis. HRQoL was measured using a 36-item health survey. Various statistical methods were employed...
March 17, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28301575/generation-of-murine-tumor-cell-lines-deficient-in-mhc-molecule-surface-expression-using-the-crispr-cas9-system
#9
Krishna Das, David Eisel, Clarissa Lenkl, Ashish Goyal, Sven Diederichs, Elke Dickes, Wolfram Osen, Stefan B Eichmüller
In this study, the CRISPR/Cas9 technology was used to establish murine tumor cell lines, devoid of MHC I or MHC II surface expression, respectively. The melanoma cell line B16F10 and the murine breast cancer cell line EO-771, the latter stably expressing the tumor antigen NY-BR-1 (EO-NY), were transfected with an expression plasmid encoding a β2m-specific single guide (sg)RNA and Cas9. The resulting MHC I negative cells were sorted by flow cytometry to obtain single cell clones, and loss of susceptibility of peptide pulsed MHC I negative clones to peptide-specific CTL recognition was determined by IFNγ ELISpot assay...
2017: PloS One
https://www.readbyqxmd.com/read/28301190/involvement-of-serotonin-and-oxytocin-in-neural-mechanism-regulating-amicable-social-signal-in-male-mice-implication-for-impaired-recognition-of-amicable-cues-in-balb-c-strain
#10
Hiroyuki Arakawa
Social signals play a primary role in regulating social relationships among male mice. The present series of experiments investigated the neural mechanisms underlying an induction of amicable cues that facilitate social approach in male mice of the C57BL/6 (B6) and BALB/c (BALB) strains. Male mice exhibit approach behavior and suppression of territorial scent marking toward amicable counterparts. Exposure of a group-housed mouse that maintains an amicable relationship induced social approach in B6 recipient mice, as expressed by increased preference of stay in proximity and decreased scent marks relevant to those of a single-housed mouse...
April 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28298774/a-survey-on-awareness-about-the-role-of-anesthesia-and-anesthesiologists-among-the-patients-undergoing-surgeries-in-a-tertiary-care-teaching-women-and-children-hospital
#11
Vinay Marulasiddappa, H N Nethra
BACKGROUND: Although anesthesiology has grown tremendously and although anesthesiologists play a crucial role in the perioperative management of patients and also outside operating theater (OT) such as critical care, pain clinic, and labor analgesia, they do not get due recognition. We conducted a study to assess the awareness about the role of anesthesia and anesthesiologists among patients scheduled to undergo surgery in a Government Tertiary Care Teaching Women and Children Hospital...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28297684/physical-and-occupational-therapy-utilization-in-a-pediatric-intensive-care-unit
#12
Liang R Cui, Megan LaPorte, Matthew Civitello, Meg Stanger, Maxine Orringer, Frank Casey, Bradley A Kuch, Sue R Beers, Cynthia A Valenta, Patrick M Kochanek, Amy J Houtrow, Ericka L Fink
PURPOSE: To characterize the use of physical therapy (PT) and occupational therapy (OT) consultation in our pediatric intensive care unit (PICU). MATERIALS AND METHODS: We studied children aged 1week-18years admitted to a tertiary care PICU for ≥3days. Patient characteristics, details of PT and OT sessions and adverse events were collected. A multivariable logistic regression was performed to determine factors associated with receipt of PT and OT consultation with propensity analysis followed by a regression for factors associated with outcome...
March 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28294877/-the-presidium-of-the-russian-academy-of-sciences-issued-a-decision-to-award-a-gold-medal-i-p-pavlov-2016
#13
(no author information available yet)
Redakcionnaya kollegiya jurnala "Kardiologiya" ot vsei dushi pozdravlyaet svoego kollegu, akademika Leonida Valentinovicha Rozencshtrauha s prisujdeniem Zolotoi medali imeni I.P. Pavlova 2016 g. i jelaet dalneishih tvorcheskih uspehov na poprishe Rossiiskoi nauki!
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28293930/anti-interleukin-9-antibody-increases-the-effect-of-allergen-specific-immunotherapy-in-murine-allergic-rhinitis
#14
Ji Hyeon Shin, Do Hyun Kim, Boo Young Kim, Sung Won Kim, Se Hwan Hwang, Joohyung Lee, Soo Whan Kim
PURPOSE: Interleukin (IL)-9 induces allergic responses; however, the roles of anti-IL-9 antibody in the induction of tolerance remain unclear. This study investigated the effects of anti-IL-9 antibody on oral tolerance (OT) in a mouse model of allergic rhinitis (AR). METHODS: BALB/c mice were divided into 4 groups: the control, AR, OT, and OT with anti-IL-9 antibody (OT+IL9AB) groups. Ovalbumin (OVA) was used for sensitization and challenge. Mice in the OT and OT+IL9AB groups were fed OVA for immunotherapy...
May 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28293156/indications-of-implant-removal-a-study-of-83-cases
#15
Muhammad Haseeb, Muhammad Farooq Butt, Tariq Altaf, Khalid Muzaffar, Anil Gupta, Aleena Jallu
INTRODUCTION: Fracture fixation has become advanced with the advent of new and custom metal implants for each type of bone/fracture. After union though, the implant ceases to be important and may be removed. Routine removal is advocated by some and opposed by others. Nevertheless, some patients require removal of the hardware because of various implant-related problems. Our study was aimed at identifying the most common causes for implant removal. OBJECTIVE: To investigate the common indications of orthopedic implant removal surgeries...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28290551/epithelial-lt%C3%AE-r-signaling-controls-the-population-size-of-the-progenitors-of-medullary-thymic-epithelial-cells-in-neonatal-mice
#16
Weiwei Wu, Yaoyao Shi, Huan Xia, Qian Chai, Caiwei Jin, Boyang Ren, Mingzhao Zhu
The establishment of T cell central tolerance critically relies on the development and maintenance of the medullary thymic epithelial cells (mTECs). Disrupted signaling of lymphotoxin beta receptor (LTβR) results in dramatically reduced mTEC population. However, whether LTβR directly or indirectly control mTECs remains undetermined; how LTβR controls this process also remain unclear. In this study, by utilizing K14-Cre × Ltbr(fl/fl) conditional knockout (cKO) mice, we show that epithelial intrinsic LTβR was essential for the mTEC development postnatally...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289281/oxytocin-by-intranasal-and-intravenous-routes-reaches-the-cerebrospinal-fluid-in-rhesus-macaques-determination-using-a-novel-oxytocin-assay
#17
M R Lee, K B Scheidweiler, X X Diao, F Akhlaghi, A Cummins, M A Huestis, L Leggio, B B Averbeck
Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a peptide, delivery by the intranasal (IN) route is the preferred method in clinical studies. Although studies have shown increased cerebrospinal fluid (CSF) OT levels following IN administration, this does not unequivocably demonstrate that the peripherally administered OT is entering the CSF. For example, it has been suggested that peripheral delivery of OT could lead to central release of endogenous OT. It is also unknown whether the IN route provides for more efficient entry of the peptide into the CSF compared to the intravenous (IV) route, which requires blood-brain barrier penetration...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28283085/pseudocontact-shifts-in-biomolecular-nmr-using-paramagnetic-metal-tags
#18
REVIEW
Christoph Nitsche, Gottfried Otting
No abstract text is available yet for this article.
February 2017: Progress in Nuclear Magnetic Resonance Spectroscopy
https://www.readbyqxmd.com/read/28279754/estrogen-receptors-er%C3%AE-and-er%C3%AE-participation-in-hypothalamus-pituitary-adrenal-axis-activation-by-hemorrhagic-stress
#19
Luana Maria Silva Alves, Procópio Cleber Gama de Barcellos Filho, Celso Rodrigues Franci
The sympato-adrenal-system and hypothalamus-pituitary-adrenal (HPA) axis are anatomically and functionally connected with participation of several brain areas that express estrogen receptors (ERα and ERβ). We assessed the neuronal activity of these areas for FOS expression and the action of PPT (ERα agonist) or DPN (ERβ agonist) in HPA axis activity during hemorrhagic stress. Ovariectomized Wistar rats treated with vehicle (DMSO) or ER agonists were catheterized for blood collection. Animals received (control) or not (hemorrhagic) immediate reposition with the same volume of saline...
March 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28279458/elimination-of-visceral-leishmaniasis-in-the-indian-subcontinent-a-comparison-of-predictions-from-three-transmission-models
#20
Epke A Le Rutte, Lloyd A C Chapman, Luc E Coffeng, Sarah Jervis, Epco C Hasker, Shweta Dwivedi, Morchan Karthick, Aritra Das, Tanmay Mahapatra, Indrajit Chaudhuri, Marleen C Boelaert, Graham F Medley, Sridhar Srikantiah, T Deirdre Hollingsworth, Sake J de Vlas
We present three transmission models of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) with structural differences regarding the disease stage that provides the main contribution to transmission, including models with a prominent role of asymptomatic infection, and fit them to recent case data from 8 endemic districts in Bihar, India. Following a geographical cross-validation of the models, we compare their predictions for achieving the WHO VL elimination targets with ongoing treatment and vector control strategies...
March 2017: Epidemics
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