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Phlebotomy

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https://www.readbyqxmd.com/read/29672267/point-of-care-creatinine-testing-for-kidney-function-measurement-prior-to-contrast-enhanced-diagnostic-imaging-evaluation-of-the-performance-of-three-systems-for-clinical-utility
#1
Beverly Snaith, Martine A Harris, Bethany Shinkins, Marieke Jordaan, Michael Messenger, Andrew Lewington
BACKGROUND: Acute kidney injury (AKI) can occur rarely in patients exposed to iodinated contrast and result in contrast-induced AKI (CI-AKI). A key risk factor is the presence of preexisting chronic kidney disease (CKD); therefore, it is important to assess patient risk and obtain kidney function measurement prior to administration. Point-of-care (PoC) testing provides an alternative strategy but there remains uncertainty, with respect to diagnostic accuracy and clinical utility. METHODS: A device study compared three PoC analysers (Nova StatSensor, Abbott i-STAT and Radiometer ABL800 FLEX) with a reference laboratory standard (Roche Cobas 8000 series, enzymatic creatinine)...
April 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29620054/haemochromatosis
#2
REVIEW
Pierre Brissot, Antonello Pietrangelo, Paul C Adams, Barbara de Graaff, Christine E McLaren, Olivier Loréal
Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in hepcidin-ferroportin binding. Hepcidin regulates the activity of ferroportin, which is the only identified cellular iron exporter. The most common form of haemochromatosis is due to homozygous mutations (specifically, the C282Y mutation) in HFE, which encodes hereditary haemochromatosis protein. Non-HFE forms of haemochromatosis due to mutations in HAMP, HJV or TFR2 are much rarer...
April 5, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29613950/-immediate-effects-of-blood-donation-on-physical-and-cognitive-performance-a-randomized-controlled-double-blinded-trial
#3
Håkon S Eliassen, Tor Hervig, Sebastian Backlund, Joar Sivertsen, Vegard Vereiede Iversen, Morten Kristoffersen, Eivind Wengaard, Arne Gramstad, Theodor Fosse, Christopher K Bjerkvig, Torunn Apelseth, Heidi Doughty, Geir Strandenes
BACKGROUND: The success of implementing Damage Control Resuscitation principles pre-hospital has been at the expense of several logistic burdens including the requirements for resupply, and the question of donor safety during the development of whole blood programs. Previous studies have reported effects on physical performance after blood donation, however none have investigated the effects of blood donation on cognitive performance. METHOD: We describe a prospective double blinded, randomized controlled study comprised of a battery of tests: three cognitive tests, and VO2max testing on a cycle ergometer...
March 22, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29588838/the-clinical-management-of-hereditary-haemochromatosis
#4
REVIEW
Marinos Pericleous, Claire Kelly, Charles Vijay
Hereditary haemochromatosis is an autosomal recessive disorder with variable penetrance. Most patients are C282Y homozygotes while heterozygotes or patients who are homozygous with other mutations are uncommonly affected. The true genotype to phenotype expression remains unclear. Treatment with phlebotomy is highly effective and cost-efficient while liver transplantation confers a curative option.
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29579503/effect-of-peripheral-iv-based-blood-collection-on-catheter-dwell-time-blood-collection-and-patient-response
#5
Deborah F Mulloy, Susan M Lee, Matthew Gregas, Kate E Hoffman, Stanley W Ashley
AIM: To evaluate the effect of daily PIV-based phlebotomy using the PIVO device on PIVC dwell times and replacement rates, as well as the reliability of blood sample collection, and patient response to this method of blood collection. BACKGROUND: Blood draws which are also known as phlebotomy for laboratory analyses are one of the most common experiences for hospitalized patients. When performed by venipuncture, they are often associated with pain and anxiety for patients...
April 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29562830/the-impact-of-the-difficult-vascular-access-fear-and-anxiety-level-in-children-on-the-success-of-first-time-phlebotomy
#6
Gülçin Özalp Gerçeker, Dijle Ayar, Emine Zahide Özdemir, Murat Bektaş
PURPOSE: This study aimed to investigate the success of first-time phlebotomy and the affecting factors in children between 4 and 10 years of age. METHODS: This descriptive, comparative, and cross-sectional study was conducted on 155 children who underwent phlebotomy. The Sociodemographic Data Form, the Children's Anxiety Meter-State, the Children's Fear Scale, and the Difficult Intravenous Access score were used to collect the data for the study. The relationship between the success of first-time phlebotomy, mean pre-phlebotomy fear and anxiety score, and Difficult Intravenous Access score were examined...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29561389/a-novel-implementation-of-magnetic-levitation-to-quantify-leukocyte-size-morphology-and-magnetic-properties-to-identify-patients-with-sepsis
#7
Mikkel S Andersen, Shulin Lu, Gregory J Lopez, Annmarie T Lassen, Nathan I Shapiro, Ionita C Ghiran
BACKGROUND: We have developed a novel, easily implementable methodology using magnetic levitation to quantify circulating leukocyte size, morphology, and magnetic properties, which may help in rapid, bed side screening for sepsis. OBJECTIVE: Our objectives were 1) to describe our methodological approach to leukocyte assessment; and 2) to perform a pilot investigation to test the ability of magnetic levitation to identify and quantify changes in leukocyte size, shape, density and/or paramagnetic properties in healthy controls and septic patients...
March 20, 2018: Shock
https://www.readbyqxmd.com/read/29561172/later-morning-phlebotomy-and-the-potential-effect-on-early-discharge
#8
Hyung J Cho, Aislyn C DiRisio
No abstract text is available yet for this article.
March 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29559294/effects-of-virtual-reality-and-external-cold-and-vibration-on-pain-in-7-to-12-year-old-children-during-phlebotomy-a-randomized-controlled-trial
#9
Gülçin Ö Gerçeker, Şeyda Binay, Elif Bilsin, Ayşe Kahraman, Hatice B Yılmaz
PURPOSE: The aim of this study was to evaluate the effects of the virtual reality (VR) and external cold and vibration methods on pain scores in children aged 7 to 12 years during phlebotomy. DESIGN: A randomized controlled study. METHODS: The sample of children (n = 121) was allocated to the groups (group 1, VR; group 2, external cold and vibration; group 3, control) by blocked randomization. Pain scores were assessed after the phlebotomy using self-report, parent's reports, report from the nurse who attempted the phlebotomy, and researchers' report with the Wong-Baker FACES scale...
March 17, 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/29557180/evaluation-of-a-community-s-risk-for-canine-parvovirus-and-distemper-using-antibody-testing-and-gis-mapping-of-animal-shelter-intakes
#10
Miranda E Spindel, Matthew R Krecic, Margaret R Slater, Nicole Vigil
This cross-sectional study aimed to identify where dogs with negative antibody tests to canine parvovirus (CPV) and canine distemper virus (CDV) originated when entering a community shelter, using a commercially available ELISA antibody test and Geographic Information Systems mapping. Of 2745 canines entering during a three-month period, 1056 test results were obtained. Dogs or puppies weighing over 2 lb were eligible if they could be humanely, nonchemically restrained for phlebotomy. Age and minor health issues weren't exclusions...
March 20, 2018: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/29543671/iron-overload-cardiomyopathy-from-diagnosis-to-management
#11
Carles Díez-López, Josep Comín-Colet, José González-Costello
PURPOSE OF REVIEW: Iron overload cardiomyopathy (IOC) is an important predictor of prognosis in a significant number of patients with hereditary hemochromatosis and hematologic diseases. Its prevalence is increasing because of improved treatment strategies, which significantly improve life expectancy. We will review diagnosis, treatment, and recent findings in the field. RECENT FINDINGS: The development of preclinical translational disease models during the last years have helped our understanding of specific disease pathophysiological pathways that might eventually change the outcomes of these patients...
March 14, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29534684/a-novel-splicing-site-irp1-somatic-mutation-in-a-patient-with-pheochromocytoma-and-jak2-v617f-positive-polycythemia-vera-a-case-report
#12
Ying Pang, Garima Gupta, Chunzhang Yang, Herui Wang, Thanh-Truc Huynh, Ziedulla Abdullaev, Svetlana D Pack, Melanie J Percy, Terence R J Lappin, Zhengping Zhuang, Karel Pacak
BACKGROUND: The role of the hypoxia signaling pathway in the pathogenesis of pheochromocytoma/paraganglioma (PPGL)-polycythemia syndrome has been elucidated. Novel somatic mutations in hypoxia-inducible factor type 2A (HIF2A) and germline mutations in prolyl hydroxylase type 1 and type 2 (PHD1 and PHD2) have been identified to cause upregulation of the hypoxia signaling pathway and its target genes including erythropoietin (EPO) and its receptor (EPOR). However, in a minority of patients presenting with this syndrome, the genetics and molecular pathogenesis remain unexplained...
March 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29518637/-blood-letting-self-phlebotomy-in-injecting-anabolic-androgenic-steroids-within-performance-and-image-enhancing-drug-pied-culture
#13
Rebekah Brennan, John Wells, Marie Claire Van Hout
BACKGROUND: New evidence with regard to a previously undocumented practice - self phlebotomy, known as 'bloodletting' - incontemporary injecting performance and image enhancing drug (PIED) culture is the subject of this paper. While self phlebotomy has been evidenced in psychiatric patients previously, it was performed here in people who inject AAS as a self directed health care procedure. METHODS: Data was collected from five publicly accessible internet discussion forums and coded using NVivo software...
March 5, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29516487/diagnosing-diabetes-mellitus-in-patients-with-porphyria-cutanea-tarda
#14
REVIEW
Anne L Christiansen, Anette Bygum, Ole Hother-Nielsen, Lars M Rasmussen
The prevalence of diabetes mellitus is increased in patients with porphyria cutanea tarda. Different tests are available for diagnosing and screening for type II diabetes mellitus, however choosing the most suitable test is challenging. The pitfalls in the different tests along with the interfering comorbidities and treatments concerning patients with porphyria cutanea tarda complicate diagnosing these patients with diabetes mellitus. HbA1c, fasting glucose, or oral glucose tolerance are the current available tests, with HbA1c as first choice...
March 8, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29516275/polycythemia-vera
#15
REVIEW
Jerry L Spivak
Polycythemia vera (PV) is the most common myeloproliferative neoplasm (MPN), the ultimate phenotype of the JAK2 V1617F mutation, the MPN with the highest incidence of thromboembolic complications, which usually occur early in the course of the disease, and the only MPN in which erythrocytosis occurs. The classical presentation of PV is characterized by erythrocytosis, leukocytosis, and thrombocytosis, often with splenomegaly and occasionally with myelofibrosis, but it can also present as isolated erythrocytosis with or without splenomegaly, isolated thrombocytosis or isolated leukocytosis, or any combination of these...
March 7, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29511794/rational-combinations-of-in-vivo-cancer-antigen-priming-and-adoptive-t-cell-therapy-mobilize-immune-and-clinical-responses-in-terminal-cancers
#16
Qing Zhao Ruan, Jian Qian Fu, Xiao Xuan Wu, Li Ping Huang, Run Sheng Ruan
PURPOSE: It is now recognized that solid tumors encroach on the host's immune microenvironment to favor its own proliferation. Strategies to enhance the specificity of the endogenous T-cell population against tumors have been met with limited clinical success. We aimed to devise a two-tier protocol coupling in vivo whole antigen priming with ex vivo cellular expansion to clinically evaluate survival in patients following re-infusion of primed, autologous T cells, thereby determining treatment efficacy...
March 6, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29492207/evaluation-of-vascular-events-in-patients-with-myeloproliferative-syndromes-and-mutations-of-either-the-januskinase-2-or-calreticulin-gene-at-the-university-hospital-krems-from-2008-to-2015
#17
Sarah Hintermair, Elisabeth Zwickl-Traxler, Martin Pecherstorfer, Josef Singer
Myeloproliferative neoplasms (MPN), classified as polycythemia vera (PV), essential thrombocytosis (ET) and myelofibrosis (MF) are stem-cell derived disorders. Mutations in either the januskinase-2 (JAK-2) or the calreticulin (CALR) gene are characteristic for MPN and may result in enhanced proliferation of red blood cells, white blood cells and platelets, and thus increase the risk for vascular events. This study is a retrospective and descriptive analysis of records of patients, who underwent treatment for myeloproliferative syndromes at the Department of Hemato-Oncology of the University hospital Krems from 2008 to the end of 2015...
February 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29473636/corrigendum-to-nurses-knowledge-on-phlebotomy-in-tertiary-hospitals-in-china-a-cross-sectional-multicentric-survey
#18
Qian Cai, Yunxian Zhou, Dagan Yang
[This corrects the article DOI: 10.11613/BM.2018.010703.].
February 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29461167/incidence-of-hospital-acquired-anemia-in-hospitalized-dogs-and-cats
#19
Jennie L Hiratzka, Louis G Licari, Lisa K Peters
OBJECTIVE To determine the incidence of hospital-acquired anemia among dogs and cats hospitalized at a private emergency and referral center and identify possible risk factors. DESIGN Prospective, observational study. ANIMALS 56 patients (46 dogs and 10 cats). PROCEDURES Patients admitted from August 2014 through March 2015 and hospitalized for ≥ 48 hours were eligible for inclusion. Hospital-acquired anemia was defined as a PCV within reference limits on admission with development of anemia during hospitalization...
March 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29454332/do-pregnancies-reduce-iron-overload-in-hfe-hemochromatosis-women-results-from-an-observational-prospective-study
#20
Virginie Scotet, Philippe Saliou, Marianne Uguen, Carine L'Hostis, Marie-Christine Merour, Céline Triponey, Brigitte Chanu, Jean-Baptiste Nousbaum, Gerald Le Gac, Claude Ferec
BACKGROUND: HFE hemochromatosis is an inborn error of iron metabolism linked to a defect in the regulation of hepcidin synthesis. This autosomal recessive disease typically manifests later in women than men. Although it is commonly stated that pregnancy is, with menses, one of the factors that offsets iron accumulation in women, no epidemiological study has yet supported this hypothesis. The aim of our study was to evaluate the influence of pregnancy on expression of the predominant HFE p...
February 17, 2018: BMC Pregnancy and Childbirth
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