keyword
https://read.qxmd.com/read/35786274/clinical-and-laboratory-predictors-in-patients-with-acute-meningitis-in-the-gaza-strip-a-case-series
#21
JOURNAL ARTICLE
Mohammed Alkhatib, Maha Al-Faqawi, Tamer Abd-Alghafoor, Alaa Eldeen Elmassry, Khamis Elessi, Reem Mustafa
BACKGROUND: Meningitis is an infection of the membranes (meninges) surrounding the brain and spinal cord. It is a dangerous condition with potentially serious consequences if misdiagnosed or left untreated. Our study aimed to summarise the clinical and laboratory predictors in patients with acute meningitis at one hospital in the Gaza Strip. METHODS: We did a retrospective case series study of a series of randomly selected patients with meningitis who were admitted to Nasser Hospital (Gaza Strip, occupied Palestinian territory), with a target of 100 participants assessed using the ICD-10 code for meningitis...
June 2022: Lancet
https://read.qxmd.com/read/35530916/comparative-evaluation-of-the-clinical-efficacy-of-four-different-gingival-retraction-systems-an-in-vivo-study
#22
JOURNAL ARTICLE
Rahul Madaan, Jyoti Paliwal, Vineet Sharma, Kamal K Meena, Ashish Dadarwal, Roshni Kumar
INTRODUCTION: There are numerous gingival retraction systems available on the market. This study aimed to evaluate the clinical efficacy of four gingival retraction systems, namely, impregnated retraction cord, gingival retraction capsule, retraction paste, and polyvinyl acetate strips. METHODS: A total of 20 people were chosen for the study, and 100 specimens were collected. The specimens were classified into five groups based on the materials used for gingival displacement...
April 2022: Curēus
https://read.qxmd.com/read/35365068/acute-transverse-myelitis-in-an-adult-patient-with-underlying-ulcerative-colitis-a-case-report
#23
JOURNAL ARTICLE
Yi Yang, Yan Zhang
BACKGROUND: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease that limits to colon mucosa, which characterised by relapsing and remitting abdominal pain and diarrhea. Neurological complications in UC patients are usually underestimated. The most frequently reported neurological disorders associated with UC are peripheral neuropathy, cerebrovascular disease and demyelinating disease. However, acute transverse myelitis (TM) is rarely reported in UC patients. CASE PRESENTATION: We report a case of a 39-year-old man presented with fatigue, muscle weakness, numbness in the lower limbs and fingers with underlying UC...
April 1, 2022: BMC Gastroenterology
https://read.qxmd.com/read/35123429/acute-myelitis-with-multicranial-neuritis-caused-by-varicella-zoster-virus-a-case-report
#24
JOURNAL ARTICLE
Qi Liu, Xiaomeng Zhou, Zhenfei Li
BACKGROUND: Varicella zoster virus (VZV) can remain lifelong in the latent state in ganglionic neurons and adrenal glands after the initial infection. However, it can be reactivated anytime and can trigger several severe neurological manifestations such as encephalitis, meningitis, Ramsay-Hunt syndrome, cerebellitis, myelitis, and stroke. In addition, due to the diversity of clinical manifestations, clinical diagnosis of VZV can be difficult, especially in the absence of varicella. Here, we describe the case of a 52-year-old male who presented with symptoms of acute myelitis as well as polycranial neuritis, and was finally diagnosed with VZV infection through metagenomic next-generation sequencing (mNGS)...
February 5, 2022: BMC Neurology
https://read.qxmd.com/read/34894625/rapid-and-accurate-detection-of-sars-cov-2-mutations-using-a-cas12a-based-sensing-platform
#25
JOURNAL ARTICLE
Changsheng He, Cailing Lin, Guosheng Mo, Binbin Xi, An An Li, Dongchao Huang, Yanbin Wan, Feng Chen, Yufeng Liang, Qingxia Zuo, Wanqing Xu, Dongyan Feng, Guanting Zhang, Liya Han, Changwen Ke, Hongli Du, Lizhen Huang
The increasing prevalence of SARS-CoV-2 variants with spike mutations has raised concerns owing to higher transmission rates, disease severity, and escape from neutralizing antibodies. Rapid and accurate detection of SARS-CoV-2 variants provides crucial information concerning the outbreaks of SARS-CoV-2 variants and possible lines of transmission. This information is vital for infection prevention and control. We used a Cas12a-based RT-PCR combined with CRISPR on-site rapid detection system (RT-CORDS) platform to detect the key mutations in SARS-CoV-2 variants, such as 69/70 deletion, N501Y, and D614G...
December 2, 2021: Biosensors & Bioelectronics
https://read.qxmd.com/read/34588961/organization-of-the-catecholaminergic-system-in-the-short-lived-fish-nothobranchius-furzeri
#26
JOURNAL ARTICLE
Janina Borgonovo, Patricio Ahumada-Galleguillos, Alejandro Oñate-Ponce, Camilo Allende-Castro, Pablo Henny, Miguel L Concha
The catecholaminergic system has received much attention based on its regulatory role in a wide range of brain functions and its relevance in aging and neurodegenerative diseases. In the present study, we analyzed the neuroanatomical distribution of catecholaminergic neurons based on tyrosine hydroxylase (TH) immunoreactivity in the brain of adult Nothobranchius furzeri . In the telencephalon, numerous TH+ neurons were observed in the olfactory bulbs and the ventral telencephalic area, arranged as strips extending through the rostrocaudal axis...
2021: Frontiers in Neuroanatomy
https://read.qxmd.com/read/34311832/-rutin-activates-ampk%C3%AE-to-ameliorate-liver-damage-caused-by-perfluorooctanoic-acid-in-mice
#27
JOURNAL ARTICLE
Hui Liu, Fangfang Liu, Yongbing Zhou, Jingjing Cheng, Yuting Tang, Li Wang
OBJECTIVE: To study the protective effect and mechanism of rutin on perfluorooctanoic acid(PFOA)-induced liver damage in mice. METHODS: A total of 24 male ICR mice were randomly divided into 3 groups, 8 in each group: control group(ctrl group: ddH_2O), perfluorooctanoic acid group(PFOA group: PFOA 20 mg/(kg·d)), rutin intervention group(rutin+PFOA group: PFOA 20 mg/(kg·d)+rutin 20 mg/(kg·d)), normal diet, oral gavage, daily observation, weighting, and recording...
July 2021: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://read.qxmd.com/read/34103425/-actual-strategy-of-treatment-varicose-veins-recurrence-after-endovenous-interventions
#28
JOURNAL ARTICLE
A Chernookov, V Ramishvili, S Dolgov, A Nikolaev, A Atayan, E Belykh
The aim of the study is to substantiate the surgical treatment tactics of recurrence varicose veins after endovenous interventions. Early and long-term results of the treatment, quality of life of patients with recurrence of varicose veins were studied. Among the admitted patients, there were 55 (65.5%) women and 29 (34.5%) men, the age of patients varied from 19 to 76 years. Of these, 9 patients underwent crossectomy, endovenous laser coagulation - 22, various stripping options - 4, echosclerotherapy - 20, intraoperative catheter sclerobliteration - 1, ligation of perforating veins - 28 patients...
April 2021: Georgian Medical News
https://read.qxmd.com/read/33826356/pediatric-retroclival-epidural-hematoma-in-the-acute-trauma-setting-a-sign-of-tectorial-membrane-stripping-injury
#29
JOURNAL ARTICLE
Peter Fiester, Dinesh Rao, Sonia Andreou, Erik Soule, Jeet Patel
OBJECTIVE. A traumatic retroclival epidural hematoma is a rare imaging finding of severe cervical flexion-extension injury in the pediatric population. The purpose of our study was to identify pediatric patients with a retroclival epidural hematoma, record the hematoma size and extent, and examine the major craniocervical ligaments for injury. MATERIALS AND METHODS. Pediatric patients who suffered a retroclival epidural hematoma were identified retrospectively using the keywords "clivus," "epidural hematoma," and "retroclival" included in head CT reports between 2012 and 2019...
June 2021: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/33634731/lateral-flow-immunogold-assay-as-a-rapid-detection-tool-for-screening-of-congenital-hypothyroidism
#30
JOURNAL ARTICLE
Younes Sbihi, Najia El Abbadi, Abdelghani Iddar
Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation. The majority of infants are diagnosed after detection through newborn screening programs using thyroid-stimulating hormone (TSH) test. A rapid immunochromatographic lateral flow assay based on monoclonal antibodies (MAbs) colloidal gold nanoparticles was developed in a sandwich format for the detection of TSH. Two MAbs binding distinct TSH epitopes are used; one is conjugated to the detection reagent while the other is immobilized at the test line on the membrane...
February 26, 2021: Journal of Immunoassay & Immunochemistry
https://read.qxmd.com/read/33386754/microglial-recruitment-and-mechanisms-involved-in-the-disruption-of-afferent-synaptic-terminals-on-spinal-cord-motor-neurons-after-acute-peripheral-nerve-injury
#31
JOURNAL ARTICLE
Sara Salvany, Anna Casanovas, Lídia Piedrafita, Olga Tarabal, Sara Hernández, Jordi Calderó, Josep E Esquerda
Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, the loss of afferent synapses on MNs occurs in concomitance with microglial reaction by a process described as synaptic stripping. However, the way in which postaxotomy-activated microglia adjacent to MNs are involved in synaptic removal is less defined. Here, we used confocal and electron microscopy to examine interactions between recruited microglial cells and presynaptic terminals in axotomized MNs between 1 and 15 days after sciatic nerve transection in mice...
January 2, 2021: Glia
https://read.qxmd.com/read/33379855/-effects-of-astragaloside-%C3%A2-on-exosome-secretion-and-its-microrna-126-expression-in-human-endothelial-progenitor-cells
#32
JOURNAL ARTICLE
W Xiong, X Bai, H Xiao, H W Lan, C H Zhu, S Q Zhao, Y J Wu, J Chen
Objective: To investigate the effects of Astragaloside Ⅳ on the secretion of exosomes in human endothelial progenitor cells (EPCs) and the expression of microRNA (miRNA)-126 in exosomes. Methods: The umbilical cord blood from one healthy full-term newborn from the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine in 2019 was harvested for isolating mononuclear cells by density gradient centrifugation and cultured for 7 days. Morphological observation was performed during this period...
December 20, 2020: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/33238685/-research-on-feasibility-of-in-vitro-inflammatory-wound-microenvironment-simulated-by-using-inflammatory-wound-tissue-homogenate-of-mice
#33
JOURNAL ARTICLE
Y Hao, Q X Yang, Q Wang, G C Xu, F Qi, C L Deng, Z R Wei, D L Wang
Objective: To investigate the feasibility of in vitro inflammatory wound microenvironment simulated by using inflammatory wound tissue homogenate of mice. Methods: (1) Ten eight-week-old C57BL/6 male mice were collected and full-thickness skin tissue with diameter of 1.0 cm on both sides of the midline of the back was taken with a perforator to make the normal skin tissue homogenate supernatant. At 48 h after the full-thickness skin defect wound was established, the wound tissue within 2 mm from the wound edge was taken to make inflammatory wound tissue homogenate supernatant...
November 20, 2020: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/33170765/laryngeal-leukoplakia-state-of-the-art-review
#34
REVIEW
Joseph C Park, Kenneth W Altman, Vyas M N Prasad, Matthew Broadhurst, Lee M Akst
OBJECTIVE: This state-of-the-art article reviews the epidemiology, diagnosis, and management of vocal fold leukoplakia, with focus on recent advances. It focuses on the clinical challenges that otolaryngologists face balancing both oncological efficacy and functional outcomes in leukoplakia and presents the current philosophies and techniques to consider when managing such patients. DATA SOURCES: PubMed/MEDLINE. REVIEW METHODS: We conducted a detailed review of publications related to vocal cord and laryngeal leukoplakia, dysplasia, hyperkeratosis, leukoplakia endoscopy, and leukoplakia management focusing specifically on oncologic outcomes, voice preservation, current and emerging diagnosis, and management techniques...
June 2021: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/33142340/perinatal-outcomes-of-subjects-enrolled-in-a-multicenter-trial-with-a-waiver-of-antenatal-consent
#35
JOURNAL ARTICLE
Anup C Katheria, Phillip Allman, Jeff M Szychowski, Jochen Essers, Waldemar A Carlo, Georg M Schmölzer, Eugene Dempsey, Toby Yanowitz, Joseph Kaempf, Farha Vora, Shazia Bhat, Kathy Arnell, Wade Rich, Michael Varner
OBJECTIVE:  This study aimed to determine whether outcomes differed between infants enrolled in the PREMOD2 trial and those otherwise eligible but not enrolled, and whether the use of waiver effected these differences. STUDY DESIGN:  The multicenter PREMOD2 (PREmature infants receiving Milking Or Delayed cord clamping) trial was approved for waiver of antenatal consent by six of the nine sites institutional review boards, while three sites exclusively used antenatal consent...
November 3, 2020: American Journal of Perinatology
https://read.qxmd.com/read/32875764/-analysis-of-clinical-efficacy-of-c-3-expanded-half-lamina-excision-combined-with-unilateral-open-door-laminoplasty-for-multiple-segmental-cervical-spinal-cord-compression-syndrome
#36
JOURNAL ARTICLE
Ming Fang, Jian-Meng Lu, Xing-Wu Wang, Yong-Li Wei, Wu-Liang Yu, Min-Hao Lu
OBJECTIVE: To explore the clinical efficacy of C3 expanded half lamina excision combined with unilateral open door laminoplasty for multiple segmental cervical spinal cord compression syndrome. METHODS: The clinical data of 58 patients with multiple segmental cervical spinal cord compression syndrome underwent surgical treatment between September 2014 and May 2018 were retrospectively analyzed. There were 34 males and 24 females with a mean age of 64.4 years old (ranged from 46 to 78 years old)...
August 25, 2020: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://read.qxmd.com/read/32760335/a-case-with-igg4-related-spinal-pachymeningitis-causing-spinal-cord-compression
#37
Rensheng Zhang, Jiguo Gao, Teng Zhao, Beilin Zhang, Chenglin Wang, Chao Wang, Lexiang Cui, Jiafeng Chen, Shaokuan Fang
Immunoglobulin G4 (IgG4)-related disease is a systemic disease characterized by sclerosing lesions and an increased serum IgG4 level. This condition can involve any organ, but IgG4-related spinal pachymeningitis is relatively rare. In the current study, we report a case of spinal cord compression caused by IgG4-related spinal pachymeningitis. A 39-year-old man presented to us with a 15-day history of back pain and a 3-day history of dysuresia, exacerbated by weakness in the lower extremities for 2 days. Cervical magnetic resonance imaging (MRI) showed strip-shaped abnormal signals along the anterior and posterior borders of the spinal cord at the C5-T4 levels...
2020: Frontiers in Neurology
https://read.qxmd.com/read/32736591/chronic-extradural-compression-of-spinal-cord-leads-to-syringomyelia-in-rat-model
#38
JOURNAL ARTICLE
Longbing Ma, Qingyu Yao, Can Zhang, Mo Li, Lei Cheng, Fengzeng Jian
BACKGROUND: Syringomyelia is a common spinal cord lesion. However, whether CSF blockage is linked to the formation and enlargement of syringomyelia is still controversial. The current model of syringomyelia needs modification to more closely mimic the clinical situation. METHODS: We placed cotton strips under the T13 lamina of 40 8-week-old rats and blocked CSF flow by extradural compression. After 4 and 8 weeks, MRI was performed to evaluate the morphology of syringomyelia and the ratio of spinal cord diameter to syrinx diameter calculated...
July 31, 2020: Fluids and Barriers of the CNS
https://read.qxmd.com/read/32714087/comparative-analysis-of-global-gene-expression-and-complement-components-levels-in-umbilical-cord-blood-from-preterm-and-term-neonates-implications-for-significant-downregulation-of-immune-response-pathways-related-to-prematurity
#39
JOURNAL ARTICLE
Dorota Gródecka-Szwajkiewicz, Zofia Ulańczyk, Edyta Zagrodnik, Karolina Łuczkowska, Dorota Rogińska, Miłosz P Kawa, Iwona Stecewicz, Krzysztof Safranow, Przemysław Ustianowski, Sławomir Szymański, Bogusław Machaliński
Background: Preterm birth is the most frequent cause of neonatal death, but its aetiology remains unclear. It has been suggested that the imbalance of immunological mechanisms responsible for maintaining pregnancy is contributing to preterm birth pathogenesis. We aimed to investigate global gene expression and the levels of several complement system components in umbilical cord blood samples from preterm neonates and compare them to term newborns. We sought to examine how differentially expressed genes could affect various immune-related pathways that are believed to be crucial factors in preterm birth...
2020: International Journal of Medical Sciences
https://read.qxmd.com/read/32622962/graphene-nanoribbons-a-promising-nanomaterial-for-biomedical-applications
#40
REVIEW
Asha P Johnson, H V Gangadharappa, K Pramod
Graphene nanoribbons (GNRs) are narrow lengthened strips of single-layer graphene. Among the graphene family of nanomaterials, GNRs are remarkable materials due to their attractive physical, chemical, electrical, mechanical, thermal, and optical properties. They have an ultra-high surface area. Graphene-oxide nanoribbons (GONRs), the oxygenated derivative of GNRs, offer more possibilities in the biomedicine due to their amphiphilic nature. Noncovalent and covalent modifications of these are possible for advanced biomedical applications...
July 2, 2020: Journal of Controlled Release
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