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https://www.readbyqxmd.com/read/28719808/activated-neuro-oxidative-and-neuro-nitrosative-pathways-at-the-end-of-term-are-associated-with-inflammation-and-physio-somatic-and-depression-symptoms-while-predicting-outcome-characteristics-in-mother-and-baby
#1
Chutima Roomruangwong, Decio Sabbatini Barbosa, Andressa Keiko Matsumoto, André de Souza Nogueira, Buranee Kanchanatawan, Sunee Sirivichayakul, André F Carvalho, Sebastien Duleu, Michel Geffard, Estefania Gastaldello Moreira, Michael Maes
OBJECTIVES: To examine oxidative & nitrosative stress (O&NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. METHODS: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28687146/intravenous-dexmedetomidine-for-cesarean-delivery-and-its-concentration-in-colostrum
#2
M Yoshimura, T Kunisawa, M Suno, A Sugawara, A Kurosawa, R Nakanishi, K Aoki, T Toriumi
BACKGROUND: Dexmedetomidine is a sedative agent with high α2-adrenoreceptor selectivity. We investigated intravenous Dexmedetomidine administration during scheduled cesarean delivery under neuraxial anesthesia; and concentration in the colostrum. METHODS: Twenty-seven participants having elective cesarean delivery under combined spinal-epidural anesthesia were enrolled. After delivery and cord clamping, 6μg/kg/h of intravenous dexmedetomidine was administered for 10minutes, followed by a dose of 0...
May 10, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28651682/the-wuhan-twin-birth-cohort-wtbc
#3
Jinzhu Zhao, Shaoping Yang, Anna Peng, Zhengmin Qian, Hong Xian, Tianjiao Chen, Guanghui Dong, Yiming Zhang, Xijiang Hu, Zhong Chen, Jiangxia Cao, Xiaojie Song, Shunqing Xu, Tongzhang Zheng, Bin Zhang
The Wuhan Pre/Post-Natal Twin Birth Registry (WPTBR) is one of the largest twin birth registries with comprehensive medical information in China. It recruits women from the first trimester of pregnancy and their twins from birth. From January 2006 to May 2016, the total number of twins enrolled in WPTBR is 13,869 twin pairs (27,553 individuals). The WPTBR initiated the Wuhan Twin Birth Cohort (WTBC). The WTBC is a prospective cohort study carried out through incorporation of three samples. The first one comprises 6,920 twin pairs, and the second one, 6,949 twin pairs...
August 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28632316/does-umbilical-cord-milking-result-in-higher-measures-of-systemic-blood-flow-in-preterm-infants
#4
Leah Yieh, Jamie B Warren
No abstract text is available yet for this article.
June 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28622781/-iron-requirements-during-the-first-6-months-of-life
#5
A Lapillonne, O Becquet
Because of the postnatal redistribution of the iron store, the term infant born after an uneventful pregnancy virtually needs no iron during its first 6 months of life. On the other hand, several factors, such as duration of gestation, gender, mother's iron status, alteration of the iron placental transfer, significantly influence the iron store at birth. Because of their reduced body store at birth and their higher demand during catch-up growth, low birth weight infants should receive an iron supplement, which should be started earlier and given at a higher dose in the more premature infants...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28572024/maternal-exposure-to-polybrominated-diphenyl-ether-bde-209-during-lactation-affects-germ-cell-survival-with-altered-testicular-glucose-homeostasis-and-oxidative-status-through-down-regulation-of-cx43-and-p27kip1-in-prepubertal-mice-offspring
#6
Debarshi Sarkar, Shio Kumar Singh
BDE-209, a congener of polybrominated diphenyl ethers (PBDEs), is mainly used as flame retardant and accounts for over 82% of total PBDE usage. PBDEs have recently been detected in human milk and cord blood. BDE-209 possesses weak estrogenic/anti-estrogenic properties and evokes hyperglycemia through impaired glucose homeostasis in rat liver. However, little is known of the effect of lactational exposure to BDE-209 on germ cell survival in relation to testicular glucose homeostasis, estradiol and oxidative status during prepubertal period...
May 29, 2017: Toxicology
https://www.readbyqxmd.com/read/28349416/the-effect-of-the-colostral-cells-on-gene-expression-of-cytokines-in-cord-blood-cells
#7
Jiří Hrdý, Olga Novotná, Ingrid Kocourková, Ludmila Prokešová
Beneficial effect of maternal milk is acknowledged, but there is still question whether maternal milk from allergic mother is as good as from healthy one. In our study, we have assayed the effect of cells from colostrum of healthy and allergic mothers on gene expression of cytokines in cord blood cells of newborns of healthy and allergic mothers. Cytokines typical for Th1 (IL-2, IFN-gamma), Th2 (IL-4, IL-13), Tregs (IL-10, TGF-beta), and IL-8 were followed. We were not able to detect significant influence of colostral cells on gene expression of cytokines in cord blood after 2-day coculture using Transwell system...
March 28, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28347852/first-report-of-human-parechovirus-type-3-infection-in-a-pregnant-woman
#8
Makiko Shinomoto, Tatsuya Kawasaki, Takuya Sugahara, Keiko Nakata, Tomoya Kotani, Hidetaka Yoshitake, Kento Yuasa, Masashi Saeki, Yasuhiro Fujiwara
Human parechovirus type 3 (HPeV3) can cause serious conditions in neonates, such as sepsis and encephalitis, but data for adults are lacking. The case of a pregnant woman with HPeV3 infection is reported herein. A 28-year-old woman at 36 weeks of pregnancy was admitted because of myalgia and muscle weakness. Her grip strength was 6.0kg for her right hand and 2.5kg for her left hand. The patient's symptoms, probably due to fasciitis and not myositis, improved gradually with conservative treatment, however labor pains with genital bleeding developed unexpectedly 3 days after admission...
March 24, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28320218/is-early-cord-clamping-delayed-cord-clamping-or-cord-milking-best
#9
Binay Vatansever, Gamze Demirel, Elif Ciler Eren, Ozcan Erel, Salim Neselioglu, Hande Nur Karavar, Semra Gundogdu, Gozde Ulfer, Selcen Bahadir, Ayhan Tastekin
PURPOSE: To compare the antioxidant status of three cord clamping procedures (early clamping, delayed clamping and milking) by analyzing the thiol-disulfide balance. PATIENTS AND METHODS: This randomized controlled study enrolled 189 term infants who were divided into three groups according to the cord clamping procedure: early clamping, delayed clamping and milking. Blood samples were collected from the umbilical arteries immediately after clamping, and the thiol/disulfide homeostasis was analyzed...
March 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28288144/thyroid-stimulating-hormone-levels-in-newborns-and-early-life-exposure-to-endocrine-disrupting-chemicals-analysis-of-three-european-mother-child-cohorts
#10
Marijke de Cock, Michiel R de Boer, Eva Govarts, Nina Iszatt, Lubica Palkovicova, Marja H Lamoree, Greet Schoeters, Merete Eggesbø, Tomas Trnovec, Juliette Legler, Margot van de Bor
BackgroundVarious studies have reported interactions between thyroid hormones and early life chemical exposure. Our objective was to analyze the associations between markers of endocrine-disrupting chemical exposure and thyroid function in newborns, determined through heel prick blood spots.MethodsThree European mother-child cohorts (FLEHSI-Belgium, HUMIS-Norway, and the PCB cohort-Slovakia. Total n=1,784) were pooled for the purpose of this study. Data on thyroid-stimulating hormone (TSH) were obtained from national neonatal screening registries, and samples of cord plasma and/or breast milk were collected to determine exposure to various chemicals...
June 7, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28285113/ayurvedic-management-in-cervical-spondylotic-myelopathy
#11
Sarvesh Kumar Singh, Kshipra Rajoria
The age related spondylotic changes may result in direct compressive and ischemic dysfunction of the spinal cord known as cervical spondylotic myelopathy (CSM). Symptoms often develop insidiously and are characterized by neck stiffness, unilateral or bilateral deep aching neck, arm and shoulder pain, and possibly stiffness or clumsiness while walking. The management available in current mainstream medicine is not satisfactory. Various Ayurvedic treatments have been in use for these manifestations. We present a case of CSM, which was treated with a combination of Panchakarma procedures and Ayurvedic oral drugs...
January 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28255653/season-dietary-factors-and-physical-activity-modify-25-hydroxyvitamin-d-concentration-during-pregnancy
#12
Helena H Hauta-Alus, Elisa M Holmlund-Suila, Hannu J Rita, Maria Enlund-Cerullo, Jenni Rosendahl, Saara M Valkama, Otto M Helve, Timo K Hytinantti, Heljä-Marja Surcel, Outi M Mäkitie, Sture Andersson, Heli T Viljakainen
PURPOSE: The objectives of this cross-sectional study were to define maternal and umbilical cord blood (UCB) 25-hydroxyvitamin D (25(OH)D) to characterize maternal factors modifying 25(OH)D during pregnancy and predict UCB 25(OH)D in two subgroups with Declined [Δ25(OH)D <0 nmol/l] and Increased [Δ25(OH)D >0 nmol/l] 25(OH)D concentration. METHODS: A complete dataset was available from 584 women. 25(OH)D was determined at gestational weeks 6-13 and in UCB...
March 2, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28180126/providing-a-placental-transfusion-in-newborns-who-need-resuscitation
#13
REVIEW
Anup C Katheria, Melissa K Brown, Wade Rich, Kathy Arnell
Over the past decade, there have been several studies and reviews on the importance of providing a placental transfusion to the newborn. Allowing a placental transfusion to occur by delaying the clamping of the umbilical cord is an extremely effective method of enhancing arterial oxygen content, increasing cardiac output, and improving oxygen delivery. However, premature and term newborns who require resuscitation have impaired transitional hemodynamics and may warrant different methods to actively provide a placental transfusion while still allowing for resuscitation...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28115038/identification-of-mfge8-in-mesenchymal-stem-cell-secretome-as-an-anti-fibrotic-factor-in-liver-fibrosis
#14
Yu Jin Jang, Su Yeon An, Jong-Hoon Kim
The beneficial paracrine roles of mesenchymal stem cells (MSCs) in tissue repair have potential in therapeutic strategies against various diseases. However, the key therapeutic factors secreted from MSCs and their exact molecular mechanisms of action remain unclear. In this study, the cell-free secretome of umbilical cord-derived MSCs showed significant anti-fibrotic activity in the mouse models of liver fibrosis. The involved action mechanism was the regulation of hepatic stellate cell activation by direct inhibition of the TGFβ/Smad-signaling...
February 2017: BMB Reports
https://www.readbyqxmd.com/read/28109147/-co-culture-with-umbilical-cord-mesenchymal-stem-cells-promotes-the-synthesis-and-mechnism-of-milk-protein-in-bovine-mammary-epithelial-cells
#15
Yankun Zhao, Wei Shao, Chenglong Luo, Kaile Wu, Xiong Yu
Objective To explore the possible mechanism of umbilical cord mesenchymal stem cells (UCMSCs) regulating milk protein synthesis in bovine mammary gland epithelial cells (BMECs). Methods UCMSCs and BMECs were co-cultured by double-chamber Transwell(TM), and other BMECs were cultured alone as a control group. Insulin like growth factor 1 receptor (IGF-1R) inhibitor AG1024 was used to treat cells. IGF-1, β casein (CSN2) and κ casein (CSN3) content in the supernatants were determined by ELISA; the relative expression abundance of Janus kinase and signal transducer and activator of transcription factor (JAK/STAT) signaling pathway-related genes were detected by quantitative real-time PCR (qRT-PCR); and after the cells were treated with JAK2 signal blocker AG490, qRT-PCR was performed to test the relative expression abundance of CSN2 and CSN3 mRNAs...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28061522/placental-transfusion-strategies-in-italy-a-nationwide-survey-of-tertiary-care-delivery-wards
#16
Barbara Perrone, Stefano Ghirardello
Objective Delayed umbilical cord clamping and cord milking are placental transfusion strategies that produce higher iron stores and better hemodynamic conditions in a newborn. We aimed to evaluate their current practice in tertiary-care delivery wards in Italy. Study Design A multiple-choice questionnaire was e-mailed to all the 101 Italian tertiary-care delivery wards. The comparative analysis between categorical variables was performed by the χ(2) test. Result We obtained an 85% (86/101) response rate...
June 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28059609/rotavirus-specific-maternal-antibodies-and-immune-response-to-rv3-bb-neonatal-rotavirus-vaccine-in-new-zealand
#17
Mee-Yew Chen, Carl D Kirkwood, Julie Bines, Daniel Cowley, Daniel Pavlic, Katherine J Lee, Francesca Orsini, Emma Watts, Graeme Barnes, Margaret Danchin
BACKGROUND: Maternal antibodies, acquired passively via placenta and/or breast milk, may contribute to the reduced efficacy of oral rotavirus vaccines observed in children in developing countries. This study aimed to investigate the effect of rotavirus specific maternal antibodies on the serum IgA response or stool excretion of vaccine virus after any dose of an oral rotavirus vaccine, RV3-BB, in parallel to a Phase IIa clinical trial conducted at Dunedin Hospital, New Zealand. At the time of the study rotavirus vaccines had not been introduced in New Zealand and the burden of rotavirus disease was evident...
May 4, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28003539/prenatal-docosahexaenoic-acid-supplementation-does-not-affect-nonfasting-serum-lipid-and-glucose-concentrations-of-offspring-at-4-years-of-age-in-a-follow-up-of-a-randomized-controlled-clinical-trial-in-mexico
#18
RANDOMIZED CONTROLLED TRIAL
Yareni Gutierrez-Gomez, Aryeh D Stein, Usha Ramakrishnan, Albino Barraza-Villarreal, Hortensia Moreno-Macias, Carlos Aguilar-Salinas, Isabelle Romieu, Juan A Rivera
BACKGROUND: Docosahexaenoic acid (DHA) has regulatory effects on lipid and glucose metabolism. Differences in DHA availability during specific developmental windows may program metabolic changes. OBJECTIVE: We investigated the effects of maternal DHA supplementation during pregnancy on the nonfasting serum lipid and glucose concentrations of offspring at 4 y of age. METHODS: We used data from the Prenatal Omega-3 Fatty Acid Supplementation, Growth, and Development trial, a double-blind randomized controlled trial conducted in Mexico...
February 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/27956229/milk-fat-globule-egf-factor-8-secreted-by-mesenchymal-stem-cells-protects-against-liver-fibrosis-in-mice
#19
Su Yeon An, Yu Jin Jang, Hee-Joung Lim, Jiyou Han, Jaehun Lee, Gyunggyu Lee, Ji Young Park, Seo-Young Park, Ji Hyang Kim, Byung-Rok Do, Choongseong Han, Hee-Kyung Park, Ok-Hee Kim, Myeong Jun Song, Say-June Kim, Jong-Hoon Kim
BACKGROUND & AIMS: Mesenchymal stem cells (MSCs) mediate tissue repair and might be used to prevent or reduce liver fibrosis. However, little is known about the anti-fibrotic factors secreted from MSCs or their mechanisms. METHODS: Umbilical cord-derived MSCs (UCMSCs) were differentiated into hepatocyte-like cells (hpUCMSCs), medium was collected, and secretome proteins were identified and quantified using nanochip-liquid chromatography/quadrupole time-of-flight mass spectrometry...
April 2017: Gastroenterology
https://www.readbyqxmd.com/read/27936996/a-review-of-benefits-of-cord-milking-over-delayed-cord-clamping-in-the-preterm-infant-and-future-directions-of-research
#20
Azif Safarulla
PURPOSE OF REVIEW: The recommended method of handling the umbilical cord has undergone a complete 360° turn over the years and current knowledge and research has led the direction to delayed clamping and cord milking. This practice has also been supported by American College of Obstetrics and Gynecology (ACOG) in 2012. This review is a summary of current evidence on delayed cord clamping (DCC), umbilical cord milking (UCM), and comparison between the two and future directions. RECENT FINDINGS: Multiple studies have been published establishing the safety of umbilical cord milking...
January 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
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