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https://www.readbyqxmd.com/read/29338067/the-influence-of-delayed-cord-clamping-and-cord-milking-on-inflammatory-cytokines-in-umbilical-vein-and-neonatal-circulation
#1
George Daskalakis, Angeliki Papapanagiotou, Charalambos Siristatidis, Petros Drakakis, Ioanna Mole, Anastasia Barbouni, Athanasios G Papavassiliou, Vasilios Pergialiotis
The purpose of the present study was to compare the levels of tumor necrosis factor a (TNF-a), and interleukins (IL) 1, 6, 8 and 10 in the umbilical cord and neonatal circulation among neonates with early and late cord clamping MATERIAL AND METHODS: A consecutive series of 76 cases that had an uncomplicated pregnancy and an uneventful parturition was evaluated. In 40 cases delayed cord clamping was used and in the remaining 36 cases early cord clamping was practiced. Blood samples were collected from the umbilical vein immediately after cord clamping and at 24 hours from the median cubital or basilic vein of the neonate RESULTS: Significant differences were noted in the hematocrit and hemoglobin levels at 24 hours that favored delayed clamping...
January 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29334651/effects-of-perinatal-fluoride-exposure-on-the-expressions-of-mir-124-and-mir-132-in-hippocampus-of-mouse-pups
#2
Jixiang Wang, Yuliang Zhang, Zhenzhen Guo, Rui Li, Xingchen Xue, Zilong Sun, Ruiyan Niu
To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100 mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100 mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29246467/a-randomized-clinical-trial-of-umbilical-cord-milking-vs-delayed-cord-clamping-in-preterm-infants-neurodevelopmental-outcomes-at-22-26-months-of-corrected-age
#3
Anup Katheria, Donna Garey, Giang Truong, Natacha Akshoomoff, Jane Steen, Mauricio Maldonado, Debra Poeltler, Mary Jane Harbert, Yvonne E Vaucher, Neil Finer
OBJECTIVE: To compare the effect of umbilical cord milking vs delayed cord clamping (DCC) on neurodevelopmental and health outcomes in very preterm infants at 22-26 months of corrected age. STUDY DESIGN: Neurodevelopmental outcomes at 2 years of age were assessed using the Bayley Scales of Infant Development, third edition, and a standardized neurologic examination. Data regarding pulmonary morbidities, neurosensory impairments, and hospitalizations were obtained by parental interview...
December 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29234147/whole-blood-volumes-associated-with-milking-intact-and-cut-umbilical-cords-in-term-newborns
#4
Ryan M McAdams, Emily Fay, Shani Delaney
OBJECTIVE: The objective of this study is to determine placental transfusion blood volumes with intact and cut umbilical cord milking in term newborns. STUDY DESIGN: Sixty women at ≥37 weeks' gestation were enrolled. Following delivery, the umbilical cord was immediately clamped and cut to separate the newborn. Either intact umbilical cord milking (I-UCM) of the placental-umbilical cord unit or cut umbilical cord milking (C-UCM) of the cut umbilical cord segment was performed...
December 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29234144/umbilical-cord-milking-at-birth-for-term-newborns-with-acidosis-neonatal-outcomes
#5
Anup Katheria, Judith Mercer, Melissa Brown, Wade Rich, Katie Baker, M J Harbert, Brianna Pierce, Kasim Hassen, Neil Finer
OBJECTIVE: To determine if umbilical cord milking is detrimental in compromised term/near-term infants. STUDY DESIGN: A retrospective analysis of infants with abnormal cord gases (cord arterial or venous pH of ≤ 7.1 or base deficit > -12). We collected maternal risk factors, cord management, birth, and neonatal outcomes during hospitalization. RESULT: We found 157 infants who met the criteria for abnormal cord gases. Thirty-six of those had umbilical cord milking at delivery...
December 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29223822/exposure-to-acrylamide-induces-cardiac-developmental-toxicity-in-zebrafish-during-cardiogenesis
#6
Mengmeng Huang, Jingjing Jiao, Jun Wang, Zhidan Xia, Yu Zhang
Acrylamide (AA), an environmental pollutant, has been linked to neurotoxicity, genotoxicity and carcinogenicity. AA is widely used to synthesize polymers for industrial applications, is widely found in Western-style carbohydrate-rich foods and cigarette smoke, and can also be detected in human umbilical cord blood and breast milk. This is the first study that demonstrated the cardiac developmental toxicity of AA in zebrafish embryos. Post-fertilization exposure to AA caused a clearly deficient cardiovascular system with a shrunken heart and abortive morphogenesis and function...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29223775/association-between-prenatal-bisphenol-a-and-phthalate-exposures-and-fetal-metabolic-related-biomarkers-the-hokkaido-study-on-environment-and-children-s-health
#7
Machiko Minatoya, Atsuko Araki, Chihiro Miyashita, Yu Ait Bamai, Sachiko Itoh, Jun Yamamoto, Yu Onoda, Kazuki Ogasawara, Toru Matsumura, Reiko Kishi
Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to bisphenol A and phthalates...
December 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/29208663/haemodynamic-effects-of-umbilical-cord-milking-in-premature-sheep-during-the-neonatal-transition
#8
Douglas A Blank, Graeme R Polglase, Martin Kluckow, Andrew William Gill, Kelly J Crossley, Alison Moxham, Karyn Rodgers, Valerie Zahra, Ishmael Inocencio, Fiona Stenning, Domeic A LaRosa, Peter G Davis, Stuart B Hooper
OBJECTIVE: Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared the physiological effects of two UCM strategies with immediate umbilical cord clamping (UCC) and physiological-based cord clamping (PBCC) in preterm lambs. METHODS: At 126 days' gestational age, fetal lambs were exteriorised, intubated and instrumented to measure umbilical, pulmonary and cerebral blood flows and arterial pressures...
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29187078/maternal-fluoride-exposure-during-gestation-and-lactation-decreased-learning-and-memory-ability-and-glutamate-receptor-mrna-expressions-of-mouse-pups
#9
Z Sun, Y Zhang, X Xue, R Niu, J Wang
Previous investigations demonstrated that high fluoride (F) exposure may adversely affect the neurodevelopment and learning and memory ability. However, whether maternal F exposure during gestation and lactation can influence the learning, memory ability, and glutamate receptor expressions of offspring has not yet been elucidated. Hence, in the present study, maternal mice were exposed to F (25, 50, or 100 mg/L sodium fluoride (NaF) in drinking water) during gestation and lactation. Results showed that exposure to 100 mg/L NaF significantly enhanced the number of total arm entries and working memory errors of offspring in the radial arm maze test compared to the control group...
January 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29184860/safety-of-umbilical-cord-milking-in-very-preterm-neonates-a-randomized-controlled-study
#10
Soo-Youn Song, Youjin Kim, Byung-Hun Kang, Heon-Jong Yoo, Mina Lee
Objective: To investigate the safety of umbilical cord milking on both the mother and neonate among very preterm deliveries of less than 33 weeks of gestation. Methods: Pregnant women who were expected to deliver at between 24 0/7 and 32 6/7 weeks of gestation were randomized to either the umbilical cord milking or immediate cord clamping group. Maternal and neonatal data associated with delivery, in addition to neonatal morbidity and mortality data, were collected and analyzed...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29165157/the-hokkaido-birth-cohort-study-on-environment-and-children-s-health-cohort-profile-updated-2017
#11
Reiko Kishi, Atsuko Araki, Machiko Minatoya, Tomoyuki Hanaoka, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Ryu Miura, Naomi Tamura, Kumiko Ito, Houman Goudarzi
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking...
May 18, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29146078/bisphenol-a-distribution-in-serum-urine-placenta-breast-milk-and-umbilical-cord-serum-in-a-birth-panel-of-mother-neonate-pairs
#12
Jangwoo Lee, Kyungho Choi, Jeongim Park, Hyo-Bang Moon, Gyuyeon Choi, Jeong Jae Lee, Eunsook Suh, Hai-Joong Kim, So-Hee Eun, Gun-Ha Kim, Geum Joon Cho, Sung Koo Kim, Sungjoo Kim, Su Young Kim, Seunghyo Kim, Soyong Eom, Sooran Choi, Young Don Kim, Sungkyoon Kim
Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios in mother-neonate paired samples. Maternal serum, urine, placenta, breast milk, cord serum, and neonatal urine samples were collected from 318 mother-neonate pairs at six university hospitals in Korea...
November 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29109356/intrauterine-infection-with-bovine-leukemia-virus-in-pregnant-dam-with-high-viral-load
#13
Yamato Sajiki, Satoru Konnai, Asami Nishimori, Tomohiro Okagawa, Naoya Maekawa, Shinya Goto, Masashi Nagano, Junko Kohara, Nana Kitano, Toshihiko Takahashi, Motoshi Tajima, Hirohisa Mekata, Yoichiro Horii, Shiro Murata, Kazuhiko Ohashi
Enzootic bovine leukemia is caused by the bovine leukemia virus (BLV). BLV is transmitted vertically or horizontally through the transfer of infected cells via direct contact, through milk, insect bites and contaminated iatrogenic procedures. However, we lacked direct evidence of intrauterine infection. The purpose of this study was to confirm intrauterine BLV infection in two pregnant dams with high viral load by cesarean delivery. BLV was detected in cord and placental blood, and the BLV in the newborns showed 100% nucleotide identity with the BLV-env sequence from the dams...
November 6, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29101631/effect-of-placental-transfusion-on-iron-stores-in-moderately-preterm-neonates-of-30-33%C3%A2-weeks-gestation
#14
Bikramjit Das, Venkataseshan Sundaram, Praveen Kumar, William T Mordi, Lakhbir K Dhaliwal, Reena Das
OBJECTIVE: To assess the effect of placental transfusion by delayed cord clamping (DCC) of 60 s or cord milking (CM) on serum ferritin levels at hospital discharge and 3 mo of postmenstrual age (PMA) in preterm neonates of 30 to 33 wk gestation in comparison to early cord clamping (ECC) within 10 s. METHODS: This mixed longitudinal study was conducted in moderately preterm neonates of 30 to 33 wk gestation born in a level III unit in Northern India with the study sample nested within a randomized controlled trial on placental transfusion...
November 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29097178/delayed-versus-early-umbilical-cord-clamping-for-preterm-infants-a-systematic-review-and-meta-analysis
#15
Michael Fogarty, David A Osborn, Lisa Askie, Anna Lene Seidler, Kylie Hunter, Kei Lui, John Simes, William Tarnow-Mordi
OBJECTIVE: To compare the effects of delayed versus early cord clamping on hospital mortality (primary outcome) and morbidity in preterm infants using Cochrane Collaboration Neonatal Review Group methodology. DATA SOURCES: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Chinese articles, cross-referencing citations, expert informants and trial registries to 31 July 2017. STUDY ELIGIBILITY: RCTs of delayed (≥ 30 seconds) vs early (<30 seconds) clamping in infants born <37 weeks gestation...
October 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29091796/tbbpa-disposition-and-kinetics-in-pregnant-and-nursing-wistar-han-igs-rats
#16
Gabriel A Knudsen, Samantha M Hall, Alicia C Richards, Linda S Birnbaum
Tetrabromobisphenol-A (TBBPA) is a brominated flame retardant (BFR) commonly used in electronics to meet fire safety standards and has the largest worldwide production of any BFR. TBBPA has been detected in human breast milk and maternal/cord serum, indicating exposure to mothers, fetuses, and breastfeeding newborns although exposure to fetuses and newborns is poorly understood. Pregnant or nursing Wistar Han IGS rats were administered [(14)C]-TBBPA in a single dose (25 mg/kg, 2.5 μCi/kg) and euthanized between 0...
February 2018: Chemosphere
https://www.readbyqxmd.com/read/29025835/the-climb-complex-lipids-in-mothers-and-babies-study-protocol-for-a-multicentre-three-group-parallel-randomised-controlled-trial-to-investigate-the-effect-of-supplementation-of-complex-lipids-in-pregnancy-on-maternal-ganglioside-status-and-subsequent-cognitive
#17
Shuai Huang, Ting-Ting Mo, Tom Norris, Si Sun, Ting Zhang, Ting-Li Han, Angela Rowan, Yin-Yin Xia, Hua Zhang, Hong-Bo Qi, Philip N Baker
INTRODUCTION: Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk lipids (CML) in pregnancy may increase the level of fetal gangliosides (GA), with the potential to improve cognitive outcomes. METHODS AND ANALYSIS: We aim to recruit approximately 1500 pregnant women in the first trimester (11-14 weeks) and randomise them into one of the three treatment groups: standard maternal milk formulation, CML-enhanced maternal milk formulation or no maternal milk intervention with standard pregnancy advice (ie, the standard care)...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28942595/oxytocin-signaling-in-pain-cellular-circuit-system-and-behavioral-levels
#18
Pierrick Poisbeau, Valery Grinevich, Alexandre Charlet
Originally confined to the initiation of parturition and milk ejection after birth, the hypothalamic nonapeptide oxytocin (OT) is now recognized as a critical determinant of social behavior and emotional processing. It accounts for the modulation of sensory processing and pain perception as OT displays a potent analgesic effect mediated by OT receptors (OTRs) expressed in the peripheral and central nervous systems. In our chapter, we will first systemically analyze known efferent and afferent OT neuron projections, which form the anatomical basis for OT modulation of somatosensory and pain processing...
September 24, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28831660/distribution-of-polybrominated-diphenyl-ethers-in-breast-milk-cord-blood-and-placentas-a-systematic-review
#19
Jing Tang, Jin Xia Zhai
Polybrominated diphenyl ethers (PBDEs) have been extensively used as flame retardants in consumer products. PBDEs rapidly bioaccumulate in the environment, food, wild animals and humans. In this review, we investigated the harmful effects of PBDEs on humans, especially in early life, and summarised the levels of PBDEs in human biological samples (breast milk, cord blood and placentas). In addition, we described the spatiotemporal distribution of PBDEs in this review. PBDE levels in breast milk, cord blood and placentas were generally higher in North America than in other regions, such as Asia, Europe, Oceania and Africa...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28753183/serum-n-6-and-n-9-fatty-acids-correlate-with-serum-igf-1-and-growth-up-to-four-months-of-age-in-healthy-infants
#20
Emma Kjellberg, Josefine Roswall, Stefan Bergman, Birgitta Strandvik, Jovanna Dahlgren
OBJECTIVES: To study the relationship between insulin-like growth factor 1 (IGF-1), serum phospholipid fatty acids and growth in healthy full-term newborns during infancy. METHODS: Prospective observational study of a population-based Swedish cohort comprising 126 healthy, term infants investigating cord blood and serum at two days and four months of age for IGF-1 and phospholipid fatty acid profile and breast milk for fatty acids at two days and four months, compared to anthropometric measurements (SDS)...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
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