keyword
https://read.qxmd.com/read/38536624/validation-of-the-visionarray%C3%A2-chip-assay-for-hpv-dna-testing-in-histology-specimens-of-oropharyngeal-squamous-cell-carcinoma
#1
JOURNAL ARTICLE
Hani Ibrahim Channir, Simone Kloch Bendtsen, Linea Cecilie Melchior, Pia Rovsing Sandholm, Christine Mordhorst, Amanda-Louise Fenger Carlander, Christian von Buchwald, Katalin Kiss
BACKGROUND: The detection of human papillomavirus (HPV) has several implications in the diagnostic work-up and management of oropharyngeal squamous cell carcinoma (OPSCC). The choice of HPV detection assay and testing algorithms differ across institutions and vary in cost, detection targets, technical feasibility, and turnaround time. In this study, we aimed to validate the VisionArray® HPV Chip for formalin-fixed and paraffin-embedded (FFPE) samples of OPSCC using the previously applied standard pan-HPV DNA PCR assay as a reference...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38536520/expression-profile-of-circulating-exosomal-micrornas-in-leukoplakia-oral-submucous-fibrosis-and-combined-lesions-of-leukoplakia-and-oral-submucous-fibrosis
#2
JOURNAL ARTICLE
Dinesh Yasothkumar, Pratibha Ramani, Selvaraj Jayaraman, Karthikeyan Ramalingam, W M Tilakaratne
OBJECTIVES: This study aims to elucidate the expression of circulating exosomal miRNAs miRNA 21, miRNA 184, and miRNA 145 in the studied groups, including patients with (i) leukoplakia; (ii) oral submucous fibrosis; (iii) oral submucous fibrosis with leukoplakia; (iv) oral squamous cell carcinoma; and (v) healthy individuals. STUDY DESIGN: An observational study was conducted among 54 patients who reported to the outpatient department of Saveetha Dental College and Hospitals...
March 27, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38535030/trends-in-preoperative-airway-assessment
#3
REVIEW
Ioan Florin Marchis, Matei Florin Negrut, Cristina Maria Blebea, Mirela Crihan, Alexandru Leonard Alexa, Caius Mihai Breazu
Airway management is a vital part of anesthesia practices, intensive care units, and emergency departments, and a proper pre-operative assessment can guide clinicians' plans for securing an airway. Complex airway assessment has recently been at the forefront of anesthesia research, with a substantial increase in annual publications during the last 20 years. In this paper, we provide an extensive overview of the literature connected with pre-operative airway evaluation procedures, ranging from essential bedside physical examinations to advanced imaging techniques such as ultrasound (US), radiography, computed tomography (CT), and magnetic resonance imaging (MRI)...
March 13, 2024: Diagnostics
https://read.qxmd.com/read/38534035/adverse-jaw-outcomes-from-immune-checkpoint-inhibitors-for-head-and-neck-cancer-case-reports
#4
JOURNAL ARTICLE
Gayathri Subramanian, Vincent Yeung, Soly Baredes, Sung Kim, Tessa Bergsbaken, Samuel Quek
Radiation treatment plays a mainstream role in the management of head and neck squamous cell carcinomas (HNSCCs). Adverse effects from radiation therapy include osteoradionecrosis of the jaw, and rarely, pathologic fracture. Immune checkpoint inhibitors (ICI) such as pembrolizumab are of growing relevance to the management of metastatic and recurrent HNSCCs. Adverse impacts on bone secondary to medications such as pembrolizumab and nivolumab have been sporadically documented in the literature. The objective of this manuscript is to raise awareness of possible increase in risk for adverse jaw outcomes in patients with HNSCCs exposed to both radiation treatment to the jaws and ICI therapy...
March 27, 2024: Quintessence International
https://read.qxmd.com/read/38533771/head-and-neck-reconstruction-with-the-superficial-circumflex-iliac-artery-perforator-scip-free-flap-lessons-learned-after-73-cases
#5
JOURNAL ARTICLE
Mario F Scaglioni, Matteo Meroni, Patrick E Tomasetti, Gunesh P Rajan
BACKGROUND: Head and neck tissue defects after ablative surgery often require complex and composite reconstructions. The superficial circumflex iliac artery perforator (SCIP) flap is an extremely versatile perforator-based flap with minimal donor site morbidity, which may represent the optimal procedure in this setting. Over the last 5 years, we collected a large base of experience, including both simple and chimeric SCIP-based reconstruction, making this flap our first choice for head and neck reconstructions...
March 27, 2024: Head & Neck
https://read.qxmd.com/read/38532540/exploring-trauma-patterns-and-contributing-factors-with-slim-straight-electrode-array-after-cochlear-implantation
#6
JOURNAL ARTICLE
Renato Torres, Hannah Daoudi, Wenxi Gu, Eugénie Breil, Evelyne Ferrary, Olivier Sterkers, Yann Nguyen, Isabelle Mosnier
OBJECTIVE: To assess trauma patterns associated with the insertion of lateral wall electrode arrays. The study focused on 3 categories-scala tympani (ST), intermediate, and scala vestibuli (SV)-to identify traumatic patterns and contributing factors. STUDY DESIGN: Retrospective study. SETTING: Data from 106 cochlear implant recipients at a tertiary otologic center. METHODS: Demographic and surgical data were collected from recipients who underwent cochlear implantation manually and with RobOtol®...
March 26, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38530463/prospective-development-study-of-the-versius-surgical-system-for-use-in-transoral-robotic-surgery-an-ideal-stage-1-2a-first-in-human-and-initial-case-series-experience
#7
JOURNAL ARTICLE
Jack Faulkner, Asit Arora, Peter McCulloch, Stephen Robertson, Aleix Rovira, Sebastien Ourselin, Jean-Pierre Jeannon
PURPOSE: Transoral robotic surgery is well established in the treatment paradigm of oropharyngeal pathology. The Versius Surgical System (CMR Surgical) is a robotic platform in clinical use in multiple specialities but is currently untested in the head and neck. This study utilises the IDEAL framework of surgical innovation to prospectively evaluate and report a first in human clinical experience and single centre case series of transoral robotic surgery (TORS) with Versius. METHODS: Following IDEAL framework stages 1 and 2a, the study evaluated Versius to perform first in human TORS before transitioning from benign to malignant cases...
March 26, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38530196/incidental-18f-fdg-avid-focuses-in-parotid-glands-on-pet-ct
#8
JOURNAL ARTICLE
Tejs Ehlers Klug, Sara Hillerup, André Henrique Dias, Lars Christian Gormsen, Peter Nørgaard Kristensen
BACKGROUND: The number of unexpected focal [18F]FDG-avid findings (incidentalomas) within the parotid gland (PGI) continues to increase with the expanding use of PET/CT scanning. The prevalence of malignancy in PGIs is uncertain and appropriate management is unsettled. AIMS: We aimed to explore the underlying pathologies associated with PGI. MATERIALS AND METHODS: A retrospective review of all patients with parotid gland incidentaloma(s) treated at the Ear-Nose-Throat Department, Aarhus University Hospital, Denmark in the period 2012-2021, was performed...
March 26, 2024: Acta Oto-laryngologica
https://read.qxmd.com/read/38529664/strategies-for-co-2-laser-use-in-laryngeal-microsurgery-a-systematic-review
#9
REVIEW
Vivianne Landry, Ève Sedillot-Daniel, Tareck Ayad, Andrée-Anne Leclerc
OBJECTIVE: We aim to systematically review the literature addressing perioperative practices for optimal use of the CO2 laser in laryngeal transoral laser microsurgery (TOLMS), with a focus on safety. DATA SOURCES: A systematic review of publications indexed in Medline, Embase, and EBM reviews-Cochrane Central Register of Controlled Trials which evaluated perioperative strategies for the use of CO2 laser in laryngeal TOLMS was conducted. REVIEW METHODS: Records obtained from the search strategy were assessed for eligibility in a 2-step process by 2 independent researchers using the Covidence software...
March 26, 2024: Otolaryngology—Head and Neck Surgery
https://read.qxmd.com/read/38529341/extranodal-extension-in-laryngeal-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Aman M Patel, Sudeepti Vedula, Ariana L Shaari, Hannaan S Choudhry, Andrey Filimonov
OBJECTIVE: Although large retrospective database studies have associated extranodal extension (ENE) with worse survival in several head and neck cancers, the prognostic significance of ENE in laryngeal squamous cell carcinoma (LSCC) remains unclear. Our study examines ENE and overall survival (OS) in LSCC. METHODS: The 2006-2017 National Cancer Database was queried for patients with LSCC undergoing surgical resection and neck dissection, with or without adjuvant therapy...
April 2024: Laryngoscope Investigative Otolaryngology
https://read.qxmd.com/read/38529101/mapping-the-spatial-evolution-of-proximal-femur-osteoporosis-a-retrospective-cross-sectional-study-based-on-ct-scans
#11
JOURNAL ARTICLE
Robert B Bot, Razvan Chirla, Calin Tudor Hozan, Simona Cavalu
PURPOSE: The purpose of this study was to quantify the modifications occurring in osteoporosis at the level of the human proximal femur throughout the trabecular structure, along with the identification of certain anatomic regions preferentially affected by osteoporosis. Another goal was to map the evolution of the radiodensity of the trabecular bone as osteoporosis progresses to an advanced stage. METHODS: The study included CT scans (right femur) from 51 patients, out of which 40 had various degrees of osteoporosis, but no other local pathology...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38526831/reticular-myxoid-odontogenic-neoplasm-with-novel-strn-alk-fusion-report-of-2-cases-in-3-year-old-males
#12
JOURNAL ARTICLE
Molly S Rosebush, Molly Housley Smith, Kitrina G Cordell, Nicholas Callahan, Waleed Zaid, Jeffrey Gagan, Justin A Bishop
Odontogenic tumors represent a collection of entities ranging from hamartomas to destructive benign and malignant neoplasms. Occasionally, pathologists encounter gnathic lesions which clearly exhibit an odontogenic origin but do not fit within the confines of established diagnoses. Here, we describe two such odontogenic tumors, both affecting 3-year-old males. Each case presented as a destructive, radiolucent mandibular lesion composed of mesenchymal cells, some with unique multi-lobed nuclei, frequently arranged in a reticular pattern and supported by a myxoid stroma with focal laminations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526767/a-comparison-of-clear-cell-sarcoma-to-jaw-and-salivary-tumors-bearing-ews-fusions
#13
REVIEW
Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera, A John Iafrate, Alexandre Jaquinet, Maria J Troulis
OBJECTIVE: To review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC). METHODS: PubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38526755/proceedings-of-the-2024-north-american-society-of-head-and-neck-pathology-companion-meeting-baltimore-md-march-24-2024-navigating-ancillary-studies-in-basaloid-blue-salivary-tumors
#14
REVIEW
Kristine S Wong
BACKGROUND: Basaloid salivary tumors can demonstrate significant morphologic overlap and be challenging to diagnose. METHODS: A review of select ancillary studies in basaloid salivary tumors was performed. RESULTS: A number of immunohistochemical stains, including PLAG1, HMGA2, β-catenin, MYB, and RAS Q61R, have been more recently incorporated into the diagnostic workup of basaloid salivary tumors. CONCLUSIONS: Although reported variability in their performance has perhaps limited their widespread adoption, these immunohistochemical studies can nevertheless be useful in supporting pathologic diagnoses, particularly when considered in more specific differentials or when used as a panel with other markers...
March 25, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38522353/current-management-of-carotid-body-tumors
#15
REVIEW
Hiroyuki Ozawa
Carotid body tumors (CBTs) are neoplasms that occur at the bifurcation of the carotid artery and are pathologically classified as paragangliomas. In the 4th edition of the WHO classification, paragangliomas are categorized as neoplasms with malignant potential. Clinically, about 5% of CBTs present with malignant features such as metastasis. Currently, it is challenging to distinguish between tumors with benign courses and those that present malignantly. Recent advances in genetic testing have elucidated the genetic characteristics of paragangliomas, including carotid body tumors...
March 22, 2024: Auris, Nasus, Larynx
https://read.qxmd.com/read/38522260/depth-of-invasion-as-an-independent-prognostic-factor-in-early-stage-oral-cavity-squamous-cell-carcinoma
#16
JOURNAL ARTICLE
Elizabeth S Koh, Abhinav Pandey, Victoria E Banuchi, William I Kuhel, Andrew Tassler, Theresa Scognamiglio, David I Kutler
PURPOSE: To determine the significance of depth of invasion as a predictor of recurrence and mortality in tongue and non-tongue early-stage oral cavity squamous cell carcinoma patients treated with surgery and no postoperative radiotherapy. MATERIALS AND METHODS: 344 patients with oral cavity squamous cell carcinoma from 2005 to 2022 at a tertiary academic medical center were reviewed. Patients were included if they had newly diagnosed, previously untreated T1-T2N0 disease treated with surgery alone that was observed within a follow-up of 5 years...
March 20, 2024: American Journal of Otolaryngology
https://read.qxmd.com/read/38521613/interdisciplinary-approach-to-expedited-outpatient-gastrostomy-tube-placement-in-head-and-neck-cancer-patients-a-single-center-retrospective-study
#17
JOURNAL ARTICLE
Pearce B Haldeman, Mansur A Ghani, Patricia Rubio, Minette Pineda, Joseph Califano, Assuntina G Sacco, Jeet Minocha, Zachary T Berman
RATIONALE AND OBJECTIVE: Treatment for head and neck cancer (HNC) can lead to decreased oral intake which often requires gastrostomy tube (g-tube) placement to provide nutritional support. A multidisciplinary team (MDT) consisting of interventional radiology (IR), HNC oncology and surgery, nutrition, and speech language pathology departments implemented an expedited outpatient g-tube placement pathway to reduce hospital stays and associated costs, initiate feeds sooner, and improve communication between care teams...
March 22, 2024: Academic Radiology
https://read.qxmd.com/read/38518463/epiglottic-capillary-hemangioma-in-an-adult-female-a-rare-case-report
#18
Syed Anwar Ahmad, Abdul Basit, Sarmad Javed
INTRODUCTION AND IMPORTANCE: Capillary hemangioma of larynx can occur in both pediatric and adult population. However, epiglottic capillary hemangioma in adults is a very rare presentation. Its pathophysiological basis involves self limiting and self expanding vascularization and it is a characteristically well delineated benign mass. CASE PRESENTATION: Here we present a case of a 40-year-old female who presented with complaint of per oral bleed in spitting which was about a teaspoon in quantity since 1 month...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38517817/prognostic-modeling-for-nasopharyngeal-carcinoma-nc-undergoing-concurrent-chemoradiotherapy-using-clinical-and-enhanced-mri-delta-radiomics-data-a-preliminary-study
#19
JOURNAL ARTICLE
Qiuyang Wang, Peng An, Lina Song, Junjie Liu, Jisheng Liu
BACKGROUND: Nasopharyngeal carcinoma (NC) is one of the prevalent malignancies of the head and neck region with poor prognosis. OBJECTIVE: The aim of this study is to establish a predictive model for assessing NC prognosis based on clinical and MR radiomics data, subsequently to develop a nomogram for practical application. METHODS: Retrospective analysis was conducted on clinical and imaging data collected between May 2010 and August 2018, involving 211 patients diagnosed with histologically confirmed NC who received concurrent chemoradiotherapy or radical surgery in Xiangyang No...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38515687/regulation-of-dihydroartemisinin-on-the-pathological-progression-of-laryngeal-carcinoma-through-the-periostin-yap-il-6-pathway
#20
JOURNAL ARTICLE
Xin-Yu Zhang, Rui-Cong Li, Cong Xu, Xiao-Ming Li
OBJECTIVE: Laryngeal cancer (LC) is one of the most common squamous cell carcinomas of the head and neck in clinical practice, and its incidence has been increasing in recent years, but the prognosis of the patients is not favorable. Hence, it is critical to re-understand and deeply study the causes and mechanisms of LC and explore new effective treatment methods and strategies. In this study, we analyzed the effect of Dihydroartemisinin (DHA) on the pathological progression of LC through the periostin (POSTN)/Yes-associated protein (YAP)/interleukin (IL)-6 pathway, which can provide new clinical references and guidelines...
March 30, 2024: Heliyon
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