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head and neck pathology

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https://www.readbyqxmd.com/read/29221126/the-clinicopathological-and-prognostic-significances-of-cdc73-expression-in-cancers-a-bioinformatics-analysis
#1
Hua-Chuan Zheng, Bao-Cheng Gong, Shuang Zhao
CDC73 interacts with human PAF1 complex, histone methyltransferase complex and RNA polymerase II for transcription elongation and 3' end processing. Its down-regulated expression was immunohistochemically detected in gastric, colorectal, ovarian and head and neck cancers, and positively correlated with aggressive behaviors and unfavorable prognosis of malignancies. We performed a bioinformatics analysis by using Oncomine, TCGA and KM plotter databases. It was found that CDC73 mRNA was overexpressed in gastric, lung, breast and ovarian cancers, even stratified by histological subtypes (p<0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218804/impact-of-diabetes-on-free-flap-surgery-of-the-head-and-neck-a-nsqip-analysis
#2
Jacob S Brady, Aparna Govindan, Meghan M Crippen, Andrey Filimonov, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVE: Diabetes is associated with microvascular pathology and may predispose patients undergoing microvascular surgery to complications. This study assesses diabetes as a risk factor for complications following free flap surgery of the head and neck. PATIENTS AND METHODS: In this retrospective cohort study, data on free flap surgeries of the head and neck between 2005 and 2014 was collected from the National Surgical Quality Improvement Program (NSQIP) database...
December 8, 2017: Microsurgery
https://www.readbyqxmd.com/read/29217069/infantile-hemangiomas-in-the-head-and-neck-region
#3
REVIEW
Denise M Adams, Kiersten W Ricci
Infantile hemangiomas (IHs) are benign vascular tumors of infancy most common in the region of the head and neck. Infantile hemangiomas are common; but they are extremely heterogeneous and cause a range of complications depending on their morphology, size, or location. Medical interventions for high-risk patients include topical and systemic therapies, including oral propranolol, which has revolutionized the management of IHs over the past recent years. In the following article, the authors aim to provide a review of the natural history, pathology, complications, syndromes, and medical management of infantile hemangioma...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29217054/classification-and-pathology-of-congenital-and-perinatal-vascular-anomalies-of-the-head-and-neck
#4
REVIEW
Paula E North
Accurate histopathologic description in correlation with clinical and radiological evaluation is required for treatment of vascular anomalies, both neoplastic and malformative. It is important to examine current clinical, histologic, and immunophenotypical features that distinguish the major types of congenital and perinatal vascular anomalies affecting the head and neck. General discussions of pathogenesis and molecular diagnosis must also be taken into account. This article provides an overview of the features that distinguish the major types of congenital and perinatal vascular anomalies affecting the head and neck, and summarizes the diagnostic histopathologic criteria and nomenclature currently applied to these lesions...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29216704/-prevalence-of-x-ray-signs-of-femoroacetabular-impingement-in-mexican-population
#5
R Gutiérrez-Ramos, S A Ávalos-Calderón, L A Bahena-Peniche
BACKGROUND: Femoroacetabular impingement (FAI) is a suggested diagnosis for pain in the hip in the absence of other apparent causes. It is thought to be a cause of progressive arthrosis of the hip. Our objective was to determine the prevalence of radiographic data of FAI in the adult population without hip pathology over a period of six months. MATERIAL AND METHODS: Analytical, observational, multicentric, ambispective and transverse study based on digital X-rays analysis...
May 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29215771/p16-positivity-and-regression-grade-predict-survival-after-neoadjuvant-radiotherapy-of-oscc
#6
Christina Eder-Czembirek, Irene Sulzbacher, Thorsten Fuereder, Edgar Selzer
OBJECTIVES: Survival after preoperative radiotherapy in locally advanced head and neck squamous cell cancer is associated with pathological response. The prognostic importance of p16 expression in these patients has not been established yet. MATERIALS AND METHODS: Ninety-seven oral squamous cell carcinoma patients, treated preoperatively with radiotherapy in combination with chemotherapy or cetxuximab, were included in this retrospective analysis. Survival rates were estimated by the Kaplan-Meyer method...
December 7, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29208793/assessment-of-proliferative-potential-of-odontogenic-keratocyst-and-dentigerous-cyst-using-podoplanin-an-immunohistochemical-study
#7
Sandeep Gupta, Aparna Paliwal, Nidhi Choudaha, Anish Gupta, Prashant Rao, Shekhar Grover
INTRODUCTION: Odontogenic cysts are commonly encountered lesions among head and neck pathologies. Odontogenic keratocyst (OKC) has unique features of recurrence and local aggressiveness. Podoplanin (PDP) is a lymphatic endothelial marker and is shown to be expressed in a variety of tissues. Hence, we planned to assess the significance of PDP in OKC and dentigerous cyst (DC). MATERIALS AND METHODS: The present study included assessment of immunoexpression of PDP in OKC and DC...
December 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29208591/the-second-look-procedure-for-transoral-videolaryngoscopic-surgery-for-t1-and-t2-laryngeal-oropharyngeal-and-hypopharyngeal-cancer-patients-protocol-for-a-nonrandomized-clinical-trial
#8
Goshi Nishimura, Daisuke Sano, Kenichiro Yabuki, Yasuhiro Arai, Yoshihiro Chiba, Teruhiko Tanabe, Nobuhiko Oridate
BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) has been widely applied for early T stage head and neck cancer. The resection is performed with a minimum safety margin for function preservation under a limited surgical field of view, making it difficult to be certain of complete resection. OBJECTIVE: Our aim is the evaluation of the completeness of resection by initial TOVS resection, and the possibility of primary control by TOVS alone, allowing for repeat procedures for function preserving treatment in early T stage laryngeal, oropharyngeal, and hypopharyngeal cancer patients...
December 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29208319/defining-the-incidence-and-clinical-significance-of-lymph-node-metastasis-in-soft-tissue-sarcoma
#9
Emily Z Keung, Yi-Ju Chiang, Rachel K Voss, Janice N Cormier, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland
INTRODUCTION: The incidence and clinical significance of lymph node metastasis (LNM, N1) in soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS (ETSTS). We sought to define the subgroup of patients with LNM at sarcoma diagnosis across all disease sites and histologies. METHODS: We identified and categorized 89,870 STS patients from the National Cancer Data Base (1998-2012) by nodal stage. Pathologically confirmed LNM (pN1) were identified in 1404 patients; 1750 had clinically suspicious but not pathologically confirmed LNM (cN1)...
November 27, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203318/lymph-node-ratio-as-a-prognostic-factor-for-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#10
Daisuke Sano, Kenichiro Yabuki, Hideaki Takahashi, Yasuhiro Arai, Yoshihiro Chiba, Teruhiko Tanabe, Goshi Nishimura, Nobuhiko Oridate
OBJECTIVE: The purpose of this study is to validate the concept of lymph node ratio (LNR) in head and neck squamous cell carcinoma (HNSCC). METHODS: A total of 63 patients with HNSCC who underwent resection of the primary tumor combined with neck dissection in our institution were analyzed in this study. LNR was defined as the number of positive lymph nodes divided by the total number of lymph nodes excised. LNR was categorized into two groups (<0.068 and ≥0...
December 1, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29200960/solitary-fibrous-tumor-occurring-in-the-parotid-gland-a-case-report
#11
Meryem Rais, Amine Kessab, Zahra Sayad, Sanae El Mourabit, Redallah Zrarqi, Salma Benazzou, Malik Boulaadas, Nadia Cherradi
Background: Solitary fibrous tumor is an uncommon spindle cell neoplasm of unknown origin. It has been reported in many anatomic sites, with a rare occurrence in the head and neck region. Solitary fibrous tumors of the parotid gland are exceptional; their clinical and radiologic features are non specific, often mimicking more common salivary gland tumors. Pathologic examination and immunohistochemistry are required to make the correct diagnosis. The prognosis is favorable, with most tumors being benign, and complete surgical resection is the treatment of choice...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29198524/single-cell-transcriptomic-analysis-of-primary-and-metastatic-tumor-ecosystems-in-head-and-neck-cancer
#12
Sidharth V Puram, Itay Tirosh, Anuraag S Parikh, Anoop P Patel, Keren Yizhak, Shawn Gillespie, Christopher Rodman, Christina L Luo, Edmund A Mroz, Kevin S Emerick, Daniel G Deschler, Mark A Varvares, Ravi Mylvaganam, Orit Rozenblatt-Rosen, James W Rocco, William C Faquin, Derrick T Lin, Aviv Regev, Bradley E Bernstein
The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and response to therapy. We profiled transcriptomes of ∼6,000 single cells from 18 head and neck squamous cell carcinoma (HNSCC) patients, including five matched pairs of primary tumors and lymph node metastases. Stromal and immune cells had consistent expression programs across patients. Conversely, malignant cells varied within and between tumors in their expression of signatures related to cell cycle, stress, hypoxia, epithelial differentiation, and partial epithelial-to-mesenchymal transition (p-EMT)...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29189861/-study-and-management-of-thyroid-nodes-by-non-specialist-physicians-soched-consensus
#13
Hernán Tala, René E Díaz, José Miguel Domínguez Ruiz-Tagle, Jorge Sapunar Zenteno, Pedro Pineda, Patricia Arroyo Albala, Marcela Barberán, Patricio Cabané, Francisco Cruz Olivos, Patricio Gac E, Andrea Glasinovic Pizarro, Hernán E González, Francisca Grob, Maria Soledad Hidalgo Valle, Rodrigo Jaimovich, Alejandra Lanas, Claudio Liberman, Maite Lobo Guiñez, Arturo Madrid
The thyroid nodule is a frequent cause of primary care consultation. The prevalence of a palpable thyroid nodule is approximately 4-7%, increasing up to 67% by the incidental detection of nodules on ultrasound. The vast majority are benign and asymptomatic, staying stable over time. The clinical importance of studying a thyroid nodule is to exclude thyroid cancer, which occurs in 5 to 10% of the nodules. The Board of SOCHED (Chilean Society of Endocrinology and Diabetes) asked the Thyroid Study Group to develop a consensus regarding the diagnostic management of the thyroid nodule in Chile, aimed at non-specialist physicians and adapted to the national reality...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29187807/characteristic-mirna-expression-signature-and-random-forest-survival-analysis-identify-potential-cancer-driving-mirnas-in-a-broad-range-of-head-and-neck-squamous-cell-carcinoma-subtypes
#14
Yury O Nunez Lopez, Berta Victoria, Pawel Golusinski, Wojciech Golusinski, Michal M Masternak
Aim: To characterize the miRNA expression profile in head and neck squamous cell carcinoma (HNSSC) accounting for a broad range of cancer subtypes and consequently identify an optimal miRNA signature with prognostic value. Background: HNSCC is consistently among the most common cancers worldwide. Its mortality rate is about 50% because of the characteristic aggressive behavior of these cancers and the prevalent late diagnosis. The heterogeneity of the disease has hampered the development of robust prognostic tools with broad clinical utility...
January 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29184758/atlantoaxial-rotatory-displacement-in-children
#15
David Spiegel, Shikshya Shrestha, Prakash Sitoula, Norma Rendon, John Dormans
AIM: To correlate the Pang and Lee class with the clinical course in a consecutive series of patients presenting with painful torticollis. METHODS: Forty-seven dynamic rotational computed tomography (CT) scans in 35 patients were classified into one of the five types defined by Pang and Li, including types I (atlantoaxial rotatopry fixation), II ("pathologic stickiness" without crossover of C1 on C2), III ("pathologic stickiness" with crossover of C1 on C2), IV (normal or muscular torticollis), and V (diagnostic grey zone)...
November 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29183528/conditional-survival-based-abbreviated-routine-cancer-surveillance-for-pathologic-stage-ib-melanoma
#16
Moshim Kukar, Emmanuel Gabriel, Rebecca May, Edward Cho, Michelle Lichtenthal, Adrienne Groman, Joseph Skitzki, Valerie Francescutti, John M Kane
A negative sentinel lymph node biopsy (SLNB) for stage IB (T1b/T2a N0) melanoma would predict an excellent long-term prognosis. Combined with the concept of conditional survival, an "abbreviated" cancer surveillance strategy was implemented to reduce the number of visits and total length of follow-up. Retrospective review of all pathologic stage IB melanoma patients (negative SLNB) at a single institution between 2006 and 2008 after implementation of an "abbreviated" cancer surveillance; clinic visits every six months for five years followed by one annual visit (total follow-up six years)...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29182124/hip-preservation-surgery-for-adolescents-and-young-adults-with-post-perthes-sequelae
#17
M A Eid
BACKGROUND: Impingement ensures a narrow arc of pathologic loading in adolescent hips with sequelae of Perthes Disease. Proper surgical interference when the hip is still in the pre-arthritic stage restores function and protects the young hip from early degenerative changes. METHODS: Osteochondroplasty at the femoral head-neck junction and relative lengthening of the femoral neck by distal transfer of the greater trochanter was performed for 12 adolescents with combined intra-articular/extra-articular impingement due to sequelae of Perthes disease in terms of coxa magna, coxa plana, coxa brevis, with an overriding greater trochanter...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29181079/survivin-expression-hpv-positivity-and-microvessel-density-in-oropharyngeal-carcinomas-and-relationship-with-survival-time
#18
Ebru Tastekin, Vuslat Yurut Caloglu, Nilufer Kilic Durankus, Necdet Sut, Gorkem Turkkan, Nuray Can, Fulya Oz Puyan, Murat Caloglu
Introduction: Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis. Material and methods: Pathological materials and demographic properties of 46 patients were retrospectively evaluated. Survivin, HPV and CD34 (for microvessel density evaluation) antibodies were applied tumoral tissues...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29178364/fine-needle-aspiration-cytology-for-parotid-lesions-can-we-avoid-surgery
#19
Yotam Shkedy, Uri Alkan, Aviram Mizrahi, Tzippy Shochat, Orr Dimitstein, Sara Morgenstern, Thomas Shpitzer, Gideon Bachar
OBJECTIVE: Salivary gland neoplasms are rare tumors, with most arising in the parotid gland. Fine-needle aspiration cytology (FNAC) is a common method for pre-operative evaluation of parotid masses, although its usefulness is controversial. This study was designed to evaluate the accuracy of FNAC in a large cohort of patients, with emphasis on diagnosis of benign tumors and especially Warthin tumor which can be managed conservatively. STUDY DESIGN: Retrospective case series with chart review...
November 27, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29173757/head-and-neck-cancer-survivorship-learning-the-needs-meeting-the-needs
#20
REVIEW
Jolie Ringash, Lori J Bernstein, Gerald Devins, Colleen Dunphy, Meredith Giuliani, Rosemary Martino, Sara McEwen
Cancers of the head and neck and the treatments required to control them frequently result in serious and persistent impairments that can affect participation and quality of life. Increased recognition of the needs of cancer survivors and their caregivers has prompted research focused on the unique concerns of this complex group. Unmet needs have been identified among 60-70% of patients and a similar proportion of their partners; impacts can include profound social effects, isolation, and psychiatric conditions...
January 2018: Seminars in Radiation Oncology
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