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Michael Hombach, Marion Jetter, Peter M Keller, Nicolas Blöchliger, Natalia Kolesnik-Goldmann, Erik C Böttger
Background: In principle, automated systems allow rapid reading of disc diffusion AST (rAST) within 6-8 h. Objectives: This study analysed whether rAST can discriminate resistance phenotypes such as ESBL, carbapenemases and MRSA/methicillin-resistant Staphylococcus epidermidis from WT populations. We describe species-drug combinations that may require clinical breakpoint adaptions for early reading due to zone diameter changes during the incubation period. Methods: In total, 1852 clinical strains [Escherichia coli (n = 475), Klebsiella pneumoniae (n = 375), Enterobacter cloacae (n = 301), Staphylococcus aureus (n = 407) and S...
November 1, 2017: Journal of Antimicrobial Chemotherapy
Michael Hombach, Marion Jetter, Nicolas Blöchliger, Natalia Kolesnik-Goldmann, Erik C Böttger
Background: Antibiotic resistance poses a significant threat to patients suffering from infectious diseases. Early readings of antibiotic susceptibility test (AST) results could be of critical importance to ensure adequate treatment. Disc diffusion is a well-standardized, established and cost-efficient AST procedure; however, its use in the clinical laboratory is hampered by the many manual steps involved, and an incubation time of 16-18 h, which is required to achieve reliable test results...
June 1, 2017: Journal of Antimicrobial Chemotherapy
Thomas J Kirn
The automation of specimen processing and culture workup has rapidly emerged in clinical microbiology laboratories throughout the world and more recently in the United States. While many U.S. laboratories have implemented some form of automated specimen processing and some have begun performing digital plate reading, automated colony analysis is just beginning to be utilized clinically. In this issue of the Journal of Clinical Microbiology, M. L. Faron et al. (J Clin Microbiol 54:2470-2475, 2016, http://dx...
October 2016: Journal of Clinical Microbiology
Matthew L Faron, Blake W Buchan, Christopher Coon, Theo Liebregts, Anita van Bree, Arjan R Jansz, Genevieve Soucy, John Korver, Nathan A Ledeboer
Vancomycin-resistant enterococci (VRE) are an important cause of health care-acquired infections (HAIs). Studies have shown that active surveillance of high-risk patients for VRE colonization can aid in reducing HAIs; however, these screens generate a significant cost to the laboratory and health care system. Digital imaging capable of differentiating negative and "nonnegative" chromogenic agar can reduce the labor cost of these screens and potentially improve patient care. In this study, we evaluated the performance of the WASPLab Chromogenic Detection Module (CDM) (Copan, Brescia, Italy) software to analyze VRE chromogenic agar and compared the results to technologist plate reading...
October 2016: Journal of Clinical Microbiology
Giorgio Da Rin, Maira Zoppelletto, Giuseppe Lippi
BACKGROUND: Although automation has become widely utilized in certain areas of diagnostic testing, its adoption in diagnostic microbiology has proceeded much more slowly. OBJECTIVE: To describe our real-world experience of integrating an automated instrument for diagnostic microbiology (Walk-Away Specimen Processor, WASPLab) within a model of total laboratory automation (TLA). METHODS: The implementation process was divided into 2 phases. The former period, lasting approximately 6 weeks, entailed the installation of the WASPLab processor to operate as a stand-alone instrumentation, whereas the latter, lasting approximately 2 weeks, involved physical connection of the WASPLab with the automation...
February 2016: Laboratory Medicine
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