keyword
https://read.qxmd.com/read/38546551/neoadjuvant-dual-checkpoint-inhibitors-vs-anti-pd1-therapy-in-high-risk-resectable-melanoma-a-pooled-analysis
#21
JOURNAL ARTICLE
Ankit Mangla, Chanmi Lee, Matthew M Mirsky, Margaret Wang, Luke D Rothermel, Richard Hoehn, Jeremy S Bordeaux, Bryan T Carrol, Jason Theuner, Shawn Li, Pingfu Fu, John M Kirkwood
IMPORTANCE: Despite the clear potential benefits of neoadjuvant therapy, the optimal neoadjuvant regimen for patients with high-risk resectable melanoma (HRRM) is not known. OBJECTIVE: To compare the safety and efficacy of dual checkpoint inhibitors with anti-programmed cell death protein-1 (anti-PD1) therapy in a neoadjuvant setting among patients with HRRM. DESIGN, SETTING, AND PARTICIPANTS: In this pooled analysis of clinical trials, studies were selected provided they investigated immune checkpoint inhibitor treatment, were published between January 2018 and March 2023, and were phase 1, 2, or 3 clinical trials...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546449/challenging-nhs-corporate-mentality-hospital-management-and-bureaucracy-in-london-s-pandemic
#22
JOURNAL ARTICLE
Rebecca Irons
Whilst NHS Health Service management is usually characterized by hierarchized bureaucracy and profit-driven competitiveness, the COVID-19 pandemic drastically disrupted these ways of working and allowed London-based non-clinical management to experience their roles otherwise. This paper is based on 35 interviews with senior non-clinical management at a London-based NHS Trust during 'Alpha phase' of Britain's pandemic response (May-August 2020), an oft-overlooked group in the literature. I will draw upon Graeber's theory of "total bureaucratization" to argue that though the increasing neo-liberalization of the health-services has hitherto contributed toward a corporate mentality, the pandemic gave managers a chance to experience more collaboration and freedom than usual, which ultimately led to more effective realization of decision-making and change...
April 2, 2024: Medical Anthropology
https://read.qxmd.com/read/38546365/acute-burn-care
#23
JOURNAL ARTICLE
Brittany N Davis, Hope Xu, Lawrence J Gottlieb, Sebastian Q Vrouwe
LEARNING OBJECTIVES: After studying this article and viewing the videos, the participant should be able to: 1. Describe the current epidemiology of burn injuries. 2. Understand burn pathophysiology and perform a wound assessment. 3. Summarize the initial emergency management of a burn patient. 4. Calculate the anticipated fluid resuscitation requirements for a burn injury, and diagnose the complications of overresuscitation. 5. Describe the diagnosis and management of inhalation injury...
April 1, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38546326/meta-dhgnn-method-for-crs-related-cytokines-analysis-in-car-t-therapy-based-on-meta-learning-directed-heterogeneous-graph-neural-network
#24
JOURNAL ARTICLE
Zhenyu Wei, Chengkui Zhao, Min Zhang, Jiayu Xu, Nan Xu, Shiwei Wu, Xiaohui Xin, Lei Yu, Weixing Feng
Chimeric antigen receptor T-cell (CAR-T) immunotherapy, a novel approach for treating blood cancer, is associated with the production of cytokine release syndrome (CRS), which poses significant safety concerns for patients. Currently, there is limited knowledge regarding CRS-related cytokines and the intricate relationship between cytokines and cells. Therefore, it is imperative to explore a reliable and efficient computational method to identify cytokines associated with CRS. In this study, we propose Meta-DHGNN, a directed and heterogeneous graph neural network analysis method based on meta-learning...
March 27, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38546293/improvement-of-light-output-of-mapbbr-3-single-crystal-for-ultrafast-and-bright-cryogenic-scintillator
#25
JOURNAL ARTICLE
Somnath Mahato, Michal Makowski, Shaona Bose, Dominik Kowal, Md Abdul Kuddus Sheikh, Philipp Braueninger-Wemer, Marcin E Witkowski, Samit Kumar Ray, Winicjusz Drozdowski, Muhammad Danang Birowosuto
The remarkable brightness and rapid scintillation observed in perovskite single crystals (SCs) become even more striking when they are operated at cryogenic temperatures. In this study, we present advancements in enhancing the scintillation properties of methylammonium lead bromide (MAPbBr3 ) SCs by optimizing the synthesis process. We successfully synthesized millimeter-sized MAPbBr3 SCs with bright green luminescence under UV light. However, both MAPbBr3 (Control-1M and THF-0.4M) SCs display notable radioluminescence exclusively at low temperatures due to their phase transitions...
March 28, 2024: Journal of Physical Chemistry Letters
https://read.qxmd.com/read/38546207/development-of-high-performance-iron-based-phosphate-cathodes-toward-practical-na-ion-batteries
#26
JOURNAL ARTICLE
Chunliu Xu, Lin Zhou, Teng Gao, Zhao Chen, Xueyan Hou, Jiao Zhang, Ying Bai, Liangrong Yang, Huizhou Liu, Chao Yang, Junmei Zhao, Yong-Sheng Hu
Iron-based phosphate cathode of Na4 Fe3 (PO4 )2 (P2 O7 ) has been regarded as a low-cost and structurally stable cathode material for Na-ion batteries (NIBs). However, their practical application is greatly hindered by the insufficient electrochemical performance and limited energy density. Here, we report a new iron-based phosphate cathode of Na4.5 Fe3.5 (PO4 )2.5 (P2 O7 ) with the intergrown heterostructure of the maricite-type NaFePO4 and orthorhombic Na4 Fe3 (PO4 )2 (P2 O7 ) phases at a mole ratio of 0...
March 28, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38546138/live-biotherapeutic-products-for-the-prevention-of-recurrent-clostridioides-difficile-infection
#27
REVIEW
Natasha N Pettit, Kristy M Shaeer, Elias B Chahine
OBJECTIVE: To review the efficacy, safety, and role of live biotherapeutic products (LBPs) in the prevention of recurrent Clostridioides difficile infection (rCDI). DATA SOURCES: A literature search was performed using PubMed and Google Scholar (through February 2024) with search terms RBX2660, SER-109, and fecal microbiota. Other resources included abstracts presented at recent conferences, national clinical practice guidelines, and manufacturers' websites. STUDY SELECTION AND DATA EXTRACTION: All relevant studies, trial updates, conference abstracts, and guidelines in the English language were included...
March 28, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38546089/in-vitro-evaluation-of-anti-cancer-potential-of-different-solvent-extracts-derived-from-clerodendrum-infortunatum-linn-against-cervical-cancer
#28
JOURNAL ARTICLE
Jayshree V Changade, Harsha Thanvi, Chandrashekhar Raut, Manasi Chavan, Prachi Prasad, Vaibhav S Ladke
BACKGROUND: Cervical cancer is a prevalent and deadly malignancy in females, with chemotherapy often proving ineffective due to significant side effects and the development of chemo-resistance. This study investigates the medicinal potential of Clerodendrum infortunatum linn. , a genus with approximately 500 species in the Lamiaceae family. Limited research exists on the species of Clerodendrum infortunatum and its various solvent extracts. OBJECTIVE: The study aims to assess the anti-cancer properties of different solvent extracts from this plant on human cervical cancer cells...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38546072/integrative-bioinformatics-analysis-reveals-potential-target-genes-and-pten-signaling-in-breast-cancer-and-effect-of-zingiber-officinale-ginger-and-allium-sativum-garlic-extract-on-it
#29
JOURNAL ARTICLE
Katayoon Sheybatzadeh, Seyed Ali Asghar Moshtaghie, Kahin Shahanipour, Fereshteh Golab
INTRODUCTION: Breast cancer is the most common type of cancer in women. The construction of a competing gene network is an important step in the identification of the role of hub genes in breast cancers. In the current research, we used a number of bioinformatics tools to construct this network in breast cancer and investigated the combined effect of garlic and ginger on mice model of breast cancer. MATERIALS AND METHODS: We chose female mice weighing 18-20 g that were divided into 7 groups including; the cancer group receiving normal saline, different doses of ginger extract (100 and 500 mg/kg), different doses of garlic (50 and 100 mg/kg), tamoxifen (10 mg/ kg) and simultaneous garlic (100 mg/kg) and ginger (500 mg/kg) for 3 weeks intraperitoneal...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38545952/development-of-injectable-upconversion-nanoparticle-conjugated-doxorubicin-theranostics-electrospun-nanostructure-for-targeted-photochemotherapy-in-breast-cancer
#30
JOURNAL ARTICLE
Amreen Khan, Abhishek Tripathi, Mayuri Gandhi, Jayesh Bellare, Rohit Srivastava
Nanotheranostic-based photochemotherapies with targeted drug delivery have considerably surfaced in cancer therapy. In the presented work, polyethyleneimine-coated upconversion nanoparticles were engineered to conjugate covalently with doxorubicin. Upconversion nanoparticles (UCNP)-Doxorubicin (DOX)/synthesized epidermal growth factor receptor-targeting peptide blended with polymer composite was electrospun and formulated as the injectable dosage form. The size of the UCNP and the nanofiber diameter were assessed as 26...
March 28, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38545930/regulating-the-electronic-structure-of-max-phases-based-on-rare-earth-element-sc-to-enhance-electromagnetic-wave-absorption
#31
JOURNAL ARTICLE
Youbing Li, Haoshuai Wei, Lu Chen, Chaoyin Xie, Haoming Ding, Fei Fang, Zhifang Chai, Qing Huang
MAX phases are highly promising materials for electromagnetic (EM) wave absorption because of their specific combination of metal and ceramic properties, making them particularly suitable for harsh environments. However, their higher matching thickness and impedance mismatching can limit their ability to attenuate EM waves. To address this issue, researchers have focused on regulating the electronic structure of MAX phases through structural engineering. In this study, we successfully synthesized a ternary MAX phase known as Sc2 GaC MAX with the rare earth element Sc incorporated into the M-site sublayer, resulting in exceptional conductivity and impressive stability at high temperatures...
March 28, 2024: ACS Nano
https://read.qxmd.com/read/38545929/association-of-plasma-brain-derived-tau-with-functional-outcome-after-ischemic-stroke
#32
JOURNAL ARTICLE
Tara M Stanne, Fernando Gonzalez-Ortiz, Cecilia Brännmark, Katarina Jood, Thomas Karikari, Kaj Blennow, Christina Jern
OBJECTIVES: To investigate whether circulating acute-phase brain-derived tau (BD-tau) is associated with functional outcome after ischemic stroke. METHODS: Plasma tau was measured by a novel assay that selectively quantifies BD-tau in the Sahlgrenska Academy Study on Ischemic Stroke ( SAHLSIS ), which includes adult cases with ischemic stroke and controls younger than 70 years, and in an independent cohort of adult cases of all ages ( SAHLSIS2 ). Associations with unfavorable 3-month functional outcome (modified Rankin scale score >2) were analyzed by logistic regression...
February 27, 2024: Neurology
https://read.qxmd.com/read/38545913/isolation-and-loneliness-as-pathways-to-heavy-drinking-early-in-the-pandemic
#33
JOURNAL ARTICLE
Michael Fendrich, Jessica Becker, Beth S Russell, Crystal L Park
INTRODUCTION: social isolation and forced quarantines during the early phases of the COVID-19 pandemic coincided with a steep and persistent rise in alcohol consumption among US adults. While the association between loneliness and drinking is well established, less is known about the impact of social isolation (a known correlate of loneliness) and the interplay between these two variables in relation to drinking. METHODS: we recruited US adults using the MTurk platform for an online survey in early April 2020...
March 16, 2024: Alcohol and Alcoholism
https://read.qxmd.com/read/38545618/transfemoral-prosthetic-simulators-versus-amputees-ground-reaction-forces-and-spatio-temporal-parameters-in-gait
#34
JOURNAL ARTICLE
Toshiki Kobayashi, Abu Jor, Yufan He, Mingyu Hu, Mark W P Koh, Genki Hisano, Takeshi Hara, Hiroaki Hobara
This study aimed to compare the ground reaction forces (GRFs) and spatio-temporal parameters as well as their asymmetry ratios in gait between individuals wearing a transfemoral prosthetic simulator (TFSim) and individuals with unilateral transfemoral amputation (TFAmp) across a range of walking speeds (2.0-5.5 km h-1 ). The study recruited 10 non-disabled individuals using TFSim and 10 individuals with unilateral TFAmp using a transfemoral prosthesis. Data were collected using an instrumented treadmill with built-in force plates, and subsequently, the GRFs and spatio-temporal parameters, as well as their asymmetry ratios, were analysed...
March 2024: Royal Society Open Science
https://read.qxmd.com/read/38545253/role-for-ccn1-in-lysophosphatidic-acid-response-in-pc-3-human-prostate-cancer-cells
#35
JOURNAL ARTICLE
Pravita Balijepalli, Brianna K Knode, Samuel A Nahulu, Emily L Abrahamson, Mary P Nivison, Kathryn E Meier
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive phospholipids that act as mitogens in various cancers. Both LPA and S1P activate G-protein coupled receptors (GPCRs). We examined the role of CCN1/CYR61, an inducible matricellular protein, in LPA-induced signal transduction in PC-3 human prostate cancer cells. We found that both LPA and S1P induced expression of CCN1 and CCN2 within 2-4 h. CCN1 was induced by 18:1-LPA, but not by 18:0-, 18:2-, or 18:3-LPAs. A free fatty acid receptor-4 agonist inhibited LPA-induced CCN1 induction...
March 2024: Journal of Cell Communication and Signaling
https://read.qxmd.com/read/38545092/efficacy-and-safety-of-phospholipid-nanoparticles-vbi-s-in-reversing-intractable-hypotension-in-patients-with-septic-shock-a-multicentre-open-label-repeated-measures-phase-2a-clinical-pilot-trial
#36
JOURNAL ARTICLE
Cuthbert Simpkins, Michael Moncure, Heather Klepacz, Kristopher Roach, Sadia Benzaquen, Luis Diaz-Caballero, Jonathan Cohen, Daniel Haase, Mukesh Kumar, Harven DeShield, Anthony Manasia, Juan Rodriguez, Prashanth Anamthathmakula, Nik Hurt, Bhaswati Mukherjee, Krishna Talluri
BACKGROUND: Since the 1990's attempts to favorably modulate nitric oxide (NO) have been unsuccessful. We hypothesized that because NO is lipophilic it would preferentially localize into intravascularly infused hydrophobic nanoparticles, thereby reducing its bioavailability and adverse effects without inhibiting its production. We aimed to determine the efficacy and safety of intravenous infusion of a fluid comprised of hydrophobic phospholipid nanoparticles (VBI-S) that reversibly absorb NO in the treatment of hypotension of patients in severe septic shock...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38545090/efficacy-of-oral-20-hydroxyecdysone-bio101-a-mas-receptor-activator-in-adults-with-severe-covid-19-cova-a%C3%A2-randomized-placebo-controlled-phase-2-3-trial
#37
JOURNAL ARTICLE
Suzana Margareth Lobo, Gaétan Plantefève, Girish Nair, Adilson Joaquim Cavalcante, Nara Franzin de Moraes, Estevao Nunes, Otis Barnum, Claudio Marcel Berdun Stadnik, Maria Patelli Lima, Muriel Lins, Ludhmila Abrahao Hajjar, Christopher Lipinski, Shaheen Islam, Fabiano Ramos, Tiago Simon, Jean-Benoît Martinot, Thomas Guimard, Arnaud Desclaux, Bertrand Lioger, Fernando Carvalho Neuenschwander, Bruno DeSouza Paolino, Alpesh Amin, Samuel Amil Acosta, Daniel Forde Dilling, Edgardo Cartagena, Brian Snyder, Edouard Devaud, Ana Karolina Barreto Berselli Marinho, Suzana Tanni, Patricia Medeiros Milhomem Beato, Stephan De Wit, Vani Selvan, Jeffrey Gray, Ricardo Fernandez, Valérie Pourcher, Lee Maddox, Richard Kay, Anait Azbekyan, Mounia Chabane, Cendrine Tourette, Luis Everton Esmeraldino, Pierre J Dilda, René Lafont, Jean Mariani, Serge Camelo, Sandrine Rabut, Samuel Agus, Stanislas Veillet, Waly Dioh, Rob van Maanen, Capucine Morelot-Panzini
BACKGROUND: SARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due to COVID-19. The aim of the study was to test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore the Renin-Angiotensin System equilibrium and limit the frequency of respiratory failure and mortality in adults hospitalized with severe COVID-19. METHODS: Double-blind, randomized, placebo-controlled phase 2/3 trial. Randomization: 1:1 oral BIO101 (350 mg BID) or placebo, up to 28 days or until an endpoint was reached...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38545080/left-ventricular-function-assessment-including-or-excluding-trabeculations-in-left-ventricular-non-compaction-a-preliminary-case-control-cardiac-magnetic-resonance-study
#38
JOURNAL ARTICLE
Jean-Pierre Laissy, Ahmed Ben Driss
BACKGROUND: Functional assessment of compact myocardium and hypertrabeculations in left ventricular non-compaction (LVNC) is underestimated with regards to the morphological spectrum of disease. We aimed to assess whether measuring concurrently left ventricular (LV) volume, mass and ejection fraction (LVEF) with and without trabeculation inclusion on cine magnetic resonance (cineMR) could help diagnose patients with LVNC by comparison to normal individuals with an excess of myocardial trabeculations...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38545076/implementation-of-a-high-resolution-high-contrast-magnetic-resonance-imaging-protocol-with-extended-delayed-phases-for-peritoneal-mesothelioma
#39
JOURNAL ARTICLE
Milica Medved, Hunter D D Witmer, Ankit Dhiman, Yaniv Berger, Scott K Sherman, Enal S Hindi, Samuel G Armato, Ingrid S Reiser, Aytekin Oto, Roger M Engelmann, Hedy L Kindler, Nisa C Oren, Carla B Harmath, Kiran K Turaga
BACKGROUND: Imaging of peritoneal malignancies using conventional cross-sectional imaging is challenging, but accurate assessment of peritoneal disease burden could guide better selection for definitive surgery. Here we demonstrate feasibility of high-resolution, high-contrast magnetic resonance imaging (MRI) of peritoneal mesothelioma and explore optimal timing for delayed post-contrast imaging. METHODS: Prospective data from inpatients with malignant peritoneal mesothelioma (MPM), imaged with a novel MRI protocol, were analyzed...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38545050/a-deep-learning-based-automatic-image-quality-assessment-method-for-respiratory-phase-on-computed-tomography-chest-images
#40
JOURNAL ARTICLE
Jialin Su, Meifang Li, Yongping Lin, Liu Xiong, Caixing Yuan, Zhimin Zhou, Kunlong Yan
BACKGROUND: Computed tomography (CT) chest scans have become commonly used in clinical diagnosis. Image quality assessment (IQA) for CT images plays an important role in CT examination. It is worth noting that IQA is still a manual and subjective process, and even experienced radiologists make mistakes due to human limitations (fatigue, perceptual biases, and cognitive biases). There are also kinds of biases because of poor consensus among radiologists. Excellent IQA methods can reliably give an objective evaluation result and also reduce the workload of radiologists...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
keyword
keyword
6550
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.