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https://www.readbyqxmd.com/read/29668124/a-reduced-dose-of-fluconazole-as-primary-antifungal-prophylaxis-is-not-associated-with-increased-risk-of-invasive-fungal-infections-after-allogeneic-stem-cell-transplantation-from-a-hla-identical-sibling
#1
B Sarina, J Mariotti, S Bramanti, L Morabito, R Crocchiolo, A Rimondo, F Tordato, D Pocaterra, E Casari, Chiara De Philippis, C Carlo-Stella, A Santoro, L Castagna
BACKGROUND: Invasive fungal infections (IFI) represent a common side effect of allogeneic hematopoietic stem cell transplant (allo-SCT), resulting in increased non relapse mortality (NRM) and reduced overall survival (OS) rates. 75-days of Fluconazole 400 mg/day represents the standard primary antifungal prophylaxis (PAP) after allo-SCT, especially for low-risk transplants. However, the ideal dosage of fluconazole has never been tested. METHODS: Here we report the experience of our institution on 113 consecutive patients receiving an allo-SCT from a HLA identical sibling between 1999 and 2015, where PAP consisted of fluconazole 100 mg/day only during the pre-engraftment phase...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668116/a-bis-triazacyclononane-tris-pyridyl-n9-azacryptand-beer-can-receptor-for-complexation-of-alkali-metal-and-lead-ii-cations
#2
Asha Brown, Thanthapatra Bunchuay, Christopher Crane, Nicholas White, Amber Thompson, Paul D Beer
A new bis-triazacyclononane tris-pyridyl N9-azacryptand ligand is synthesised via a convenient one-pot [2 + 3] condensation reaction between triazacyclononane and 2,6-bis(bromomethyl) pyridine in the presence of M2CO3 (M = Na, K). The proton, lithium, sodium, potassium and lead(II) complexes of the ligand are characterised in the solid state. A preliminary solution-phase competition experiment indicates that the cryptand ligand preferentially binds lead(II) in the presence of sodium, calcium, potassium and zinc cations in methanol solution...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29668045/when-does-the-influence-of-maturation-on-anthropometric-and-physical-fitness-characteristics-increase-and-subside
#3
Christopher Towlson, Stephen Cobley, Guy Parkin, Ric Lovell
The relationships between maturation and anthropometric and physical performance characteristics are dynamic and often asynchronous; confounding the capability to accurately evaluate performance during adolescence. This study aimed to (i) examine the influence of chronological age (CA) and somatic maturation (YPHV) upon anthropometric and physical performance parameters, and (ii) identify the transition/change time-points in these relationships using segmental regression. N=969 soccer players (8-18 years of age) completed anthropometric and physical test assessments, including a counter-movement jump (CMJ), agility T-test, 10 and 20m sprints, and multi-stage fitness test (MSFT)...
April 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29667896/a-phase-1-study-to-assess-the-pharmacokinetics-safety-and-tolerability-of-fremanezumab-doses-225-mg-675-mg-and-900-mg-in-japanese-and-caucasian-healthy-subjects
#4
Orit Cohen-Barak, Sivan Weiss, Michele Rasamoelisolo, Nicola Faulhaber, Paul P Yeung, Pippa S Loupe, Esther Yoon, Mohit D Gandhi, Ofer Spiegelstein, Ernesto Aycardi
Objectives The primary and secondary objectives of this phase 1 study were to evaluate the pharmacokinetic profile, safety, and immunogenicity of fremanezumab subcutaneous (sc) doses tested in phase 2 and 3 trials (225 mg, 675 mg and 900 mg) following single administration in Japanese (n = 32) and Caucasian (n = 32) healthy subjects. Methods Japanese and matched Caucasian healthy subjects were enrolled into one of four cohorts and were randomly assigned to one of four treatments: 225, 675, or 900 mg fremanezumab, or placebo...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29667845/development-of-an-instrument-to-assess-athletic-trainers-attitudes-toward-transgender-patients
#5
Kristine A Ensign, Brian M Dodge, Debra Herbenick, Carrie L Docherty
CONTEXT:   The unique contexts in which athletic trainers (ATs) work require specific tools in order to understand their attitudes toward diverse patient populations, including sexual and gender minorities. OBJECTIVE:   To develop and validate the Attitudes Toward Transgender Patients (ATTP) instrument for ATs. DESIGN:   Cross-sectional study. SETTING:   Semistructured interviews, paper-based questionnaire, and electronic questionnaire...
April 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29667787/gingival-shade-guides-colorimetric-and-spectral-modeling
#6
Razvan Ghinea, Luis Javier Herrera, María M Pérez, Ana M Ionescu, Rade D Paravina
OBJECTIVE: To design colorimetric and spectral models of gingival shade guides that adequately represent the color of human gingiva. MATERIALS AND METHODS: A previously compiled database on the spectral reflectance of healthy keratinized gingiva was used for optimization. Coverage Error (CE) and Maximal Error (ME) were optimized using CIELAB and CIEDE2000 color difference formulas. A two-phase process included an FCM algorithm and a nonlinear optimization. A t test was used to compare the performance of the different numbers of clusters/tabs in gingival shade guide models (α = ...
March 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29667691/spin-crossover-fe-ii-complexes-of-a-cross-bridged-cyclam-derivative
#7
Bohuslav Drahoš, Zdeněk Trávníček
A cross-bridged cyclam derivative containing two 2-pyridylmethyl pendant arms (L = 4,11-bis((pyridin-2-yl)methyl)-1,4,8,11-tetraaza-bicyclo[6.6.2]hexadecane) was synthesized by dialkylation of the cross-bridged cyclam with 2-chloromethylpyridine. A series of Fe(ii) complexes with L and different counter-anions of the formulas [Fe(L)][FeCl4]·H2O (1·H2O), [Fe(L)]Cl2·4H2O (2·4H2O), [Fe(L)](BF4)2·0.5CH3CN (3·0.5CH3CN) and [Fe(L)](BPh4)2·CH3OH (4·CH3OH) was prepared and thoroughly characterized. In all the cases, the [Fe(L)]2+ cation adopts a cis-V configuration with a distorted octahedral geometry, and with the FeN6 donor set...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667604/universal-doping-evolution-of-the-superconducting-gap-anisotropy-in-single-crystals-of-electron-doped-ba-fe-sub-1-x-sub-rh-sub-x-sub-sub-2-sub-as-sub-2-sub-from-london-penetration-depth-measurements
#8
Hyunsoo Kim, Makariy A Tanatar, Catalin Martin, Erick C Blomberg, Ni Ni, Sergey L Bud'ko, Paul C Canfield, Ruslan Prozorov
Doping evolution of the superconducting gap anisotropy was studied in single crystals of 4$d$-electron doped Ba(Fe$_{1-x}$Rh$_x$)$_2$As$_2$ using tunnel diode resonator measurements of the temperature variation of London penetration depth $\Delta\lambda(T)$. Single crystals with doping level representative of underdoped regime $x$ = 0.039 ($T_c=$ 15.5 K), close to optimal doping $x=$ 0.057 ($T_c=$ 24.4 K) and overdoped $x=$ 0.079 ($T_c=$ 21.5 K) and $x=$ 0.131($T_c=$ 4.9 K) were studied. Superconducting energy gap anisotropy was characterized by the exponent, $n$, by fitting the data to the power-law, $\Delta\lambda=AT^n$...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667598/a-random-phased-array-for-mr-guided-transcranial-ultrasound-neuromodulation-in-non-human-primates
#9
Vandiver Chaplin, Marshal A Phipps, Charles F Caskey
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29667505/a-comprehensive-screening-shows-that-ergothioneine-is-the-most-abundant-antioxidant-in-the-wild-macrofungus-phylloporia-ribis-ryvarden
#10
Hengqiang Zhao, Minmin Zhang, Qian Liu, Xiaoli Wang, Ruixuan Zhao, Yanling Geng, Tityee Wong, Shengbo Li, Xiao Wang
The polar and non-polar extracts from the authenticated wild mushroom Phylloporia ribis were separated by hydrophilic interaction liquid chromatography (HILIC) and by reverse phase (RP)-HPLC, respectively. A split valve separated the eluents into two fractions for free-radical scavenging analysis and for structural identification. Forty-six compounds showed scavenging activity of the stable-free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The structures of 8 antioxidants (inosine, caffeic acid, ergothioneine, p-hydroxybenzoic acid, adenosine, 3,4-dihydroxybenzaldehyde, apigenin, and naringenin) are characterized by Mass Spectrometer...
April 3, 2018: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/29667470/long-term-skeletal-effects-of-high-pull-headgear-followed-by-fixed-appliances-for-the-treatment-of-class-ii-malocclusions
#11
E Erin Bilbo, Steven D Marshall, Karin A Southard, Verrasathpurush Allareddy, Nathan Holton, Allyn M Thames, Marlene S Otsby, Thomas E Southard
OBJECTIVES: The long-term skeletal effects of Class II treatment in growing individuals using high-pull facebow headgear and fixed edgewise appliances have not been reported. The purpose of this study was to evaluate the long-term skeletal effects of treatment using high-pull headgear followed by fixed orthodontic appliances compared to an untreated control group. MATERIALS AND METHODS: Changes in anteroposterior and vertical cephalometric measurements of 42 Class II subjects (n = 21, mean age = 10...
April 18, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29667321/the-ethanol-extraction-of-prepared-psoralea-corylifolia-induces-apoptosis-and-autophagy-and-alteres-genes-expression-assayed-by-cdna-microarray-in-human-prostate-cancer-pc-3-cells
#12
Chia-Hsin Lin, Shinji Funayama, Shu-Fen Peng, Chao-Lin Kuo, Jing-Gung Chung
Prostate cancer is the most common male reproductive system cancer. The prevalence of prostate cancer in Europe and the United States is higher than that in the Asian region. However, the treatment of prostate cancer remains unsatisfactory. Psoralea corylifolia has been used to cure this disease as Chinese medicine in the Asian region. In this study, we analyzed the components of ethanol extraction of unprepared and prepared P. corylifolia by HPLC. Psoralen and isopsoralen content from the prepared P. corylifolia is twofold higher than that from unprepared, so we use the prepared extraction in this study...
April 18, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29667305/insight-into-ca-substitution-effects-on-o3-type-nani-1-3-fe-1-3-mn-1-3-o-2-cathode-materials-for-sodium-ion-batteries-application
#13
Liqi Sun, Yingying Xie, Xiao-Zhen Liao, Hong Wang, Guoqiang Tan, Zonghai Chen, Yang Ren, Jihyeon Gim, Wan Tang, Yu-Shi He, Khalil Amine, Zi-Feng Ma
O3-type NaNi1/3 Fe1/3 Mn1/3 O2 (NaNFM) is well investigated as a promising cathode material for sodium-ion batteries (SIBs), but the cycling stability of NaNFM still needs to be improved by using novel electrolytes or optimizing their structure with the substitution of different elements sites. To enlarge the alkali-layer distance inside the layer structure of NaNFM may benefit Na+ diffusion. Herein, the effect of Ca-substitution is reported in Na sites on the structural and electrochemical properties of Na1- x Cax /2 NFM (x = 0, 0...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667282/cardiac-gated-phase-contrast-magnetic-resonance-angiography-is-a-reliable-and-reproducible-technique-for-quantifying-blood-flow-in-canine-major-cranial-abdominal-vessels
#14
Francesca Del Chicca, Andrea Schwarz, Paula Grest, Florian Willmitzer, Matthias Dennler, Patrick R Kircher
Blood flow changes in cranial abdominal vessels are important contributing factors for canine hepatic disease. This prospective, experimental, pilot study aimed to evaluate cardiac-gated, phase contrast magnetic resonance angiography (PCMRA) as a method for characterizing blood flow in canine major cranial abdominal vessels. Eleven, healthy, adult beagle dogs were sampled. Cardiac-gated, phase contrast magnetic resonance angiography of the cranial abdomen was performed in each dog and blood flow was independently measured in each of the major cranial abdominal vessels by three observers, with two observers recording blood flow values once and one observer recording blood flow values three times...
April 17, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29667250/a-new-2d-echocardiographic-approach-to-evaluate-the-membrane-and-valve-movement-of-the-berlin-heart-excor-vad-chamber-in-pediatric-vad-patients
#15
Arianna Di Molfetta, Roberta Iacobelli, Gianfranco Ferrari, Sergio Filippelli, Gianluigi Perri, Alessandra Toscano, Rachele Adorisio, Paolo Guccione, Antonio Amodeo
The use of Berlin Heart EXCOR VAD (BH) is a validated therapy to bridge pediatric patients to heart transplant. Serial echocardiographic (ECHO) assessment of VAD patients is necessary to support patients' management. This work aims at developing an innovative strategy to evaluate the BH device functioning by ECHO and its interaction with the native heart in a pediatric population. ECHO evaluation of BH membrane movement, and inflow and outflow valves was performed in 2D, 2D-color Doppler, M-mode, and M-mode color Doppler to assess the functioning of the device by direct positioning of the ECHO probe on the BH cannulas and membranes...
April 2018: Artificial Organs
https://www.readbyqxmd.com/read/29667165/ion-mobility-measurements-of-multianionic-metalloporphyrin-dimers-structural-changes-induced-by-countercation-exchange
#16
Erik Schneider, Katrina Brendle, Patrick Jäger, Patrick Weis, Manfred M Kappes
We present gas-phase structures of dimers of MnIII and FeIII meso-tetra(4-sulfonatophenyl)porphyrin multianions with various amounts of sodium and hydrogen counterions. The structural assignments are achieved by combining mass spectrometry, ion mobility measurements, quantum chemical calculations, and trajectory method collision cross section calculations. For a common charge state, we observe significant topological variations in the dimer structures of [(MTPPS)2 +nX](6-n)- (M=MnIII , FeIII ; X=H, Na; n = 1-3) induced by replacing hydrogen counterions by sodium...
April 17, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29667134/two-phase-i-pharmacokinetic-and-pharmacodynamic-studies-of-dfp-10917-a-novel-nucleoside-analog-with-14-day-and-7-day-continuous-infusion-schedules
#17
Kamalesh Sankhala, Chris H Takimoto, Alain C Mita, Henry Xiong, Jordi Rodón, Amir Mehrvarz Sarshekeh, K Burns, Kenzo Iizuka, Scott Kopetz
Purpose DFP-10917 is a novel deoxycytidine analog with a unique mechanism of action. Brief exposure to high concentrations of DFP-10917 inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to DFP-10917 at low concentration causes DNA fragmentation, G2/M-phase arrest, and apoptosis. DFP-10917 demonstrated activity in tumor xenografts resistant to other deoxycytidine analogs. Experimental design Two phase I studies assessed the safety, pharmacokinetic, pharmacodynamic and preliminary efficacy of DFP-10917...
April 18, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29667133/unique-characteristics-of-regulatory-approval-and-pivotal-studies-of-orphan-anticancer-drugs-in-japan
#18
Hiroki Nakayama, Katsura Tsukamoto
The approval of orphan anticancer drugs has increased, with the number exceeding that of non-orphan drugs in Japan in recent years. Although orphan anticancer drugs may have unique characteristics due to their rarity, these have not been fully characterized. We investigated anticancer drugs approved in Japan between April 2004 and November 2017 to reveal the characteristics of regulatory approval and pivotal studies on orphan anticancer drugs compared to non-orphan drugs. The median regulatory review time and number of patients in pivotal studies on orphan anticancer drugs (281...
April 17, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29667066/population-exposure-response-analysis-of-cabozantinib-efficacy-and-safety-endpoints-in-patients-with-renal-cell-carcinoma
#19
Steven Lacy, Jace Nielsen, Bei Yang, Dale Miles, Linh Nguyen, Matt Hutmacher
BACKGROUND: In the phase III METEOR trial, tyrosine kinase inhibitor cabozantinib significantly improved progression-free survival (PFS), objective response rate (ORR), and overall survival compared to everolimus in patients with advanced renal cell carcinoma (RCC) who had received prior VEGFR inhibitor therapy. In METEOR, RCC patients started at a daily 60-mg cabozantinib tablet (Cabometyx™) dose but could reduce to 40- or 20-mg to achieve a tolerated exposure. OBJECTIVES AND METHODS: Exposure-response (ER) models were developed to characterize the relationship between cabozantinib at clinically relevant exposures in RCC patients enrolled in METEOR and efficacy (PFS and tumor response) and safety endpoints...
April 17, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29667047/investigation-of-the-mechanism-of-therapeutic-protein-drug-interaction-between-methotrexate-and-golimumab-an-anti-tnf%C3%AE-monoclonal-antibody
#20
Weirong Wang, Jocelyn Leu, Rebecca Watson, Zhenhua Xu, Honghui Zhou
A prominent example of human therapeutic protein-drug interaction (TP-DI) is between methotrexate (MTX) and anti-TNFα mAbs. One plausible mechanism for this TP-DI is through the pharmacodynamic effect of MTX on immunogenicity. However, there is no definitive evidence to substantiate this mechanism, and other competing hypotheses, such as MTX suppressing FcγRI expression thereby affecting mAb PK, have also been proposed. In order to understand this mechanism, a cynomolgus monkey study was conducted using golimumab as a model compound...
April 17, 2018: AAPS Journal
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