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https://www.readbyqxmd.com/read/29458136/changes-in-anatomic-position-of-root-canal-orifices-in-pluriradicular-teeth-following-re-location-during-endodontic-treatment
#1
Darian Rusu, Petra Surlin, Stratul Stefan-Ioan, Marius Boariu, Calniceanu Horia, Adrian Kasaj, Cosmin Sinescu, Didilescu Andreea
Direct access to the root canals in posterior teeth for endodontic treatment is most frequently facilitated by the straightening of the coronal parts of the root canals, having as a consequence the relocation of the canal orifices on the map of the floor of the pulp chamber (Christie & Thompson, 1994). This procedure intentionally moves the coronal aspect of a canal away from the center of the chamber, while simultaneously removing internal dentin from the pulp chamber walls. The aim of this study was to evaluate the displacement resulting from the relocation of root canal orifices during the initial phase of rotary root canal treatment in molars using the dental operating microscope (DOM) and digital image processing...
February 16, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29458102/%C3%AE-irradiated-chitosan-based-injectable-hydrogels-for-controlled-release-of-drug-montelukast-sodium
#2
Sadaf Hafeez, Atif Islam, Nafisa Gull, Abbas Ali, Shahzad Maqsood Khan, Saba Zia, Kalsoom Anwar, Saba Urooge Khan, Tahir Jamil
Novel pH-sensitive γ-irradiated low molecular weight chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low molecular weight irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high molecular weight CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458018/5-chloro-n4-2-isopropylsulfonyl-phenyl-n2-2-methoxy-4-4-4-methylpiperazin-1-yl-methyl-1h-1-2-3-triazol-1-yl-phenyl-pyrimidine-2-4-diamine-wy-135-a-novel-alk-inhibitor-induces-cell-cycle-arrest-and-apoptosis-through-inhibiting-alk-and-its-downstream-pathways
#3
Mengting Han, Jiwei Shen, Lijing Wang, Yu Wang, Xin Zhai, Yao Li, Meiqiao Liu, Zengqiang Li, Daiying Zuo, Yingliang Wu
Anaplastic lymphoma kinase (ALK)-positive cancers have rising morbidity and mortality in recent years, and novel chemotherapeutic drugs with no drug resistance and high activity for treating ALK-positive cancers are needed urgently. In this study, we investigated the anti-cancer effect of 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, on nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) positive cancer cell line Karpas299 and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) positive cancer cell line H2228...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457896/nature-of-the-color-of-borates-with-anti-zeolite-structure
#4
Tatyana B Bekker, Vladimir P Solntsev, Sergey V Rashchenko, Alexander P Yelisseyev, Alexey V Davydov, Alexander A Kragzhda, Alexander E Kokh, Artem B Kuznetsov, SoHyun Park
Crystals of the Mnx Ba12 (BO3 )8-2x F8x phase were grown from a high-temperature solution. This new fluoride borate is built of positively charged [Ba12 (BO3 )6 ]6+ blocks, the so-called "anti-zeolite" pattern. Using X-ray single-crystal diffraction, the bulk atomic arrangement in the centrosymmetric tetragonal unit cell in I4/mcm could be elucidated. Crystals of the (MnF6 )4- group-containing solid solution Mnx Ba12 (BO3 )8-2x F8x are dark brown in color in contrast to the differently colored crystals of (LiF4 )3- group-containing "anti-zeolite" LiBa12 (BO3 )7 F4 (P42 bc)...
February 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29457893/kinetics-thermodynamics-and-mechanism-of-a-novel-biphasic-solvent-for-co2-capture-from-flue-gas
#5
Shihan Zhang, Yao Shen, Peijing Shao, Jianmeng Chen, Lidong Wang
The main issue related to the deployment of amine-based absorption process for CO2 capture from flue gas is its intensive energy penalty. Therefore, this study screened a novel biphasic solvent, comprising a primary amine e.g., triethylenetetramine (TETA) and a tertiary amine e.g., N, N-dimethylcyclohexylamine (DMCA), to reduce the energy consumption. The TETA-DMCA blend exhibited high cyclic capacity of CO2 absorption, favorable phase separation behavior, and low regeneration heat. Kinetic analysis showed that the gas- and liquid-side mass transfer resistances were comparable in the lean solution of TETA-DMCA at 40oC, whereas the liquid-side mass transfer resistance became dominant in the rich solution...
February 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29457890/headspace-solid-phase-microextraction-coupled-to-miniaturized-microplasma-optical-emission-spectrometry-for-detection-of-mercury-and-lead
#6
Chengbin Zheng, Ligang Hu, Xiandeng Hou, Bin He, Guibin Jiang
Despite increased interest in microplasma atomic spectrometry over the past several years, its applications to field analysis of real samples still remain limited due to its low sensitivity. In this work, headspace solid-phase microextraction (HS-SPME) using PDMS/DVB fiber was used as a sample introduction method to improve the sensitivity of a miniature (6.0 cm length × 5.0 cm width × 2.8 cm height) low power (<10 W) microplasma point discharge optical emission spectrometer (PD-OES) for the determination of Hg and Pb after their derivatization with sodium tetraethylborate (NaBEt4)...
February 19, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29457889/rapid-microwave-preparation-and-composition-tuning-of-the-high-performance-magnetocalorics-mn-fe-2-p-si
#7
Jason H Grebenkemper, Joshua D Bocarsly, Emily E Levin, Gareth Seward, Colin Heikes, Craig Brown, Sumohan Misra, Fabian Seeler, Kerstin Schierle-Arndt, Stephen D Wilson, Ram Seshadri
Rapid preparation utilizing assisted microwave heating permits significantly shorter preparation times for magnetocaloric compounds in the (Mn,Fe)2 (P,Si) family, specifically samples of (Mn,Fe)2-δ P0.5 Si0.5 with starting compositions of δ = 0, 0.06, and 0.12. To fully understand the effects of processing and composition changes on structure and properties, these materials are characterized using synchrotron powder diffraction, neutron powder diffraction, electron microprobe analysis (EMPA), X-ray fluorescence (XRF), and magnetic measurements...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29457758/appraising-cervical-mucus-a-new-approach-to-evaluating-contraceptives
#8
Leo Han, Emily Padua, Alison Edelman, Jeffrey T Jensen
PURPOSE: Timing of sample collection represents a major source of variability in studies evaluating the effects of administered agents on cervical mucus in naturally-cycling women. We sought to create and validate an artificial model of the cervical mucus cycle using exogenous E2 and P4 replacement in ovarian suppressed women. MATERIALS AND METHODS: We conducted a prospective experiment (clinicaltrials.gov, NCT02969590) examining cervical mucus changes in six women during natural and artificial menstrual cycles [leuprolide acetate, estradiol transdermal patch (0...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29457540/therapeutic-efficacy-of-cd34-cell-involved-mononuclear-cell-therapy-for-no-option-critical-limb-ischemia-a-meta-analysis-of-randomized-controlled-clinical-trials
#9
Tianyue Pan, Zheng Wei, Yuan Fang, Zhihui Dong, Weiguo Fu
Early-phase clinical trials in patients with critical limb ischemia (CLI) have shown positive results of mononuclear cell therapy. The current meta-analysis investigated whether cluster of differentiation (CD) 34+ mononuclear cell therapy (CD34+ MCT) is effective for no-option CLI. Ten randomized controlled clinical studies of CD34+ MCT for no-option CLI with 479 patients were identified and analyzed for pooled results. Compared to control groups, the CD34+ MCT was associated with lower total amputation (odds ratio (OR): 0...
February 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29457264/comparison-of-left-atrial-size-and-function-in-hypertrophic-cardiomyopathy-and-in-fabry-disease-with-left-ventricular-hypertrophy
#10
María Cristina Saccheri, Tomás Francisco Cianciulli, Wilde Challapa Licidio, Jorge A Lax, Martín A Beck, Luis A Morita, Juan A Gagliardi
BACKGROUND: Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) are two diseases with a different pathophysiology, both cause left ventricular hypertrophy (LVH) and myocardial fibrosis. Although remodeling and systolic dysfunction of the left atrium (LA) are associated with atrial fibrillation and stroke in HCM, changes in the size and function of the LA have not been well studied in FD with LVH. METHODS: The following groups were studied prospectively, and their respective findings compared: 19 patients with non-obstructive HCM (Group I), 20 patients with a diagnosis of Fabry cardiomyopathy (Group II), and 20 normal subjects matched for sex and age (Group III)...
February 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29457203/challenges-and-opportunities-in-establishing-and-maintaining-newborn-screening-in-a-rural-area-of-andhra-pradesh-task-force-study-by-indian-council-of-medical-research
#11
A Radha Rama Devi, Y Ananthalakshmi, K Srimannarayana Rao
OBJECTIVE: The primary objective was to evaluate the feasibility of setting up newborn screening in rural areas in India. Secondary objective was to enhance the knowledge and awareness towards early detection of diseases by newborn screening, management of the affected baby and to impart genetic counseling. METHODS: Awareness programs were conducted at different mandals in the district for the medical practioners during the preparatory phase of the Task Force Project...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29456880/cost-effectiveness-of-nivolumab-in-patients-with-advanced-renal-cell-carcinoma-treated-in-the-united-states
#12
Charles McCrea, Sukhvinder Johal, Shuo Yang, Justin Doan
Background: We evaluated the cost-effectiveness of nivolumab versus everolimus in patients with advanced renal cell carcinoma (RCC) from a US payer perspective. Methods: A partitioned survival model consisting of three health states, progression-free survival (PFS), progressive disease, and death, was developed to evaluate the cost-effectiveness of intravenous nivolumab versus oral everolimus over a lifetime. The proportion of patients in each state was calculated based on parametric distributions fitted to PFS and overall survival (OS) data from CheckMate 025 (N = 821), a large randomized phase 3 trial of nivolumab versus everolimus for advanced RCC...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29456439/parent-training-and-skill-acquisition-and-utilization-among-spanish-and-english-speaking-latino-families
#13
Giovanni Ramos, Angela M Blizzard, Nicole E Barroso, Daniel M Bagner
In the U.S., there is a growing Latino population, in which parents primarily speak Spanish to their children. Despite the evidence that language preference is associated with level of acculturation and influences parenting practices in these families, no study has compared how Spanish-and English-speaking Latino families acquire and utilize the skills taught during parent-training programs such as Parent-Child Interaction Therapy (PCIT). Twenty-seven mother-infant Latino dyads received a home-based adaptation of the Child-Directed Interaction (CDI) phase of PCIT as part of a larger randomized control trial...
January 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29456423/evaluating-the-implementation-of-the-endotool-glycemic-control-software-system
#14
Samuel M John, Kacie Lauren Waters, Khatija Jivani
Purpose: The purpose of this study was to compare achievement of glycemic control on insulin drips before and after the implementation of EndoTool, a glucose management software system used in a community hospital setting. Methods: A retrospective chart review was performed of patients on an insulin drip who were managed before and after implementation of the EndoTool software. Fifty patients were selected for each group. Statistical analyses were run to compare metrics gathered between groups...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456257/irc-10-216-in-3-d-morphology-of-a-tp-agb-star-envelope
#15
M Guélin, N A Patel, M Bremer, J Cernicharo, A Castro-Carrizo, J Pety, J P Fonfría, M Agúndez, M Santander-García, G Quintana-Lacaci, L Velilla Prieto, R Blundell, P Thaddeus
During their late pulsating phase, AGB stars expel most of their mass in the form of massive dusty envelopes, an event that largely controls the composition of interstellar matter. The envelopes, however, are distant and opaque to visible and NIR radiation: their structure remains poorly known and the mass-loss process poorly understood. Millimeter-wave interferometry, which combines the advantages of longer wavelength, high angular resolution and very high spectral resolution is the optimal investigative tool for this purpose...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29456256/clustering-the-orion-b-giant-molecular-cloud-based-on-its-molecular-emission
#16
Emeric Bron, Chloé Daudon, Jérôme Pety, François Levrier, Maryvonne Gerin, Pierre Gratier, Jan H Orkisz, Viviana Guzman, Sébastien Bardeau, Javier R Goicoechea, Harvey Liszt, Karin Öberg, Nicolas Peretto, Albrecht Sievers, Pascal Tremblin
Context: Previous attempts at segmenting molecular line maps of molecular clouds have focused on using position-position-velocity data cubes of a single molecular line to separate the spatial components of the cloud. In contrast, wide field spectral imaging over a large spectral bandwidth in the (sub)mm domain now allows one to combine multiple molecular tracers to understand the different physical and chemical phases that constitute giant molecular clouds (GMCs). Aims: We aim at using multiple tracers (sensitive to different physical processes and conditions) to segment a molecular cloud into physically/chemically similar regions (rather than spatially connected components), thus disentangling the different physical/chemical phases present in the cloud...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29456111/methyllucidone-inhibits-stat3-activity-by-regulating-the-expression-of-the-protein-tyrosine-phosphatase-meg2-in-du145-prostate-carcinoma-cells
#17
Yena Jin, Young Hwan Kim, Jin Yong Park, Yu-Jin Lee, Hyun-Mi Oh, Sung-Kyu Choi, Dong Cho Han, Byoung-Mog Kwon
During the search for signal transducer and activator of transcription 3 (STAT3) inhibitors from natural products, methyllucidone, isolated from Lindera species (Lauraceae), was identified as a STAT3 inhibitor. Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Methyllucidone decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, Bcl-2, Mcl-1, and survivin...
February 8, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29455953/the-comprehensive-characterization-of-adrenocortical-steroidogenesis-using-two-dimensional-ultra-performance-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#18
Gellért Karvaly, Krisztián Kovács, Katalin Mészáros, Ibolya Kocsis, Attila Patócs, Barna Vásárhelyi
The perturbation of the homeostasis of adrenocortical steroids plays a fundamental role in several pathological conditions. Currently, only a few of the substances involved in steroidogenesis are routinely analysed in clinical laboratories for the diagnosis of these conditions. Recently, interest has grown over the development of clinical assays of endogenous steroids using liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, no approaches have assessed the adrenocortical steroidogenesis comprehensively...
February 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29455920/operating-room-traffic-in-total-joint-arthroplasty-identifying-patterns-and-training-the-team-to-keep-the-door-shut
#19
William G Hamilton, Colleen B Balkam, Richard L Purcell, Nancy L Parks, Jill E Holdsworth
BACKGROUND: Surgical site infections after joint arthroplasty are devastating complications and are influenced by patient, surgical, and operating room environmental factors. METHODS: In an effort to reduce the incidence of door openings (DOs) during total joint arthroplasty cases, this prospective observational study consisted of 3 phases. Phase 1 determined the baseline incidence of DOs, followed by installation of a mechanical door counter (phase 2). Finally, an educational seminar was presented to all personnel (phase 3) regarding the implications frequent DOs have on patient and surgical outcomes...
February 15, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29455849/relationship-between-proximal-aorta-morphology-and-progression-rate-of-aortic-stenosis
#20
Romain Capoulade, Jonathan G Teoh, Philipp E Bartko, Eliza Teo, Jan-Erik Scholtz, Lionel Tastet, Mylene Shen, Christos G Mihos, Yong H Park, Julio Garcia, Eric Larose, Eric M Isselbacher, Thoralf M Sundt, Thomas E MacGillivray, Serguei Melnitchouk, Brian B Ghoshhajra, Philippe Pibarot, Judy Hung
BACKGROUND: The aim of this study was to examine the association between abnormal morphology of the proximal aorta and aortic stenosis (AS) progression rate. The main hypothesis was that morphologic changes of the proximal aorta, such as effacement of the sinotubular junction (STJ), result in increased biomechanical stresses and contribute to calcification and progression of AS. METHODS: Between 2010 and 2012, 426 patients with mild to moderate AS were included in this study...
February 16, 2018: Journal of the American Society of Echocardiography
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