keyword
MENU ▼
Read by QxMD icon Read
search

Phase 3

keyword
https://www.readbyqxmd.com/read/28549358/-complication-analysis-in-lisfranc-fracture-dislocation
#1
R J García-Renedo, A Carranza-Bencano, R Leal-Gómez, F Cámara-Arrigunaga
OBJECTIVE: To value the complications and sequels for patients with Lisfrancs fracture-luxation (FLL). MATERIAL AND METHODS: A transverse ambispective study of cohorts was realized of 83 patients by diagnosis of Lisfrancs fracture-luxation. There was in use a protocol of withdrawal of information with variables related to the injury, clinical, therapeutic parameters, complications and scales of clinical valuation. RESULTS: 66 patients (79...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549145/six-month-safety-data-of-recombinant-vesicular-stomatitis-virus-zaire-ebola-virus-envelope-glycoprotein-vaccine-in-a-phase-3-double-blind-placebo-controlled-randomized-study-in-healthy-adults
#2
Scott A Halperin, Jose R Arribas, Richard Rupp, Charles P Andrews, Laurence Chu, Rituparna Das, Jakub K Simon, Matthew T Onorato, Kenneth Liu, Jason Martin, Frans A Helmond
Background.: This study (NCT02503202) evaluated the safety of recombinant vesicular stomatitis virus-Zaire Ebola virus envelope glycoprotein vaccine (rVSVΔG-ZEBOV-GP). Methods.: Overall, 1197 subjects were randomized 2:2:2:2:1; 1194 were vaccinated with 1 dose of 1 of 3 lots of rVSVΔG- ZEBOV-GP (2 × 107 plaque-forming units [pfu], n = 797; combined-lots group), a single high-dose lot of rVSVΔG-ZEBOV-GP (1 × 108 pfu, n = 264; high-dose group), or placebo (n = 133)...
May 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28548848/quantum-mechanical-study-of-the-reaction-mechanism-for-2%C3%AF-2%C3%AF-cycloaddition-of-fluorinated-methylene-groups
#3
Andrew R Motz, Andrew M Herring, Shubham Vyas, C Mark Maupin
Perfluorocyclobutyl polymers are thermally and chemically stable, may be produced without a catalyst via thermal 2π-2π cycloaddition, and can form block structures making them suitable for commercialization of specialty polymers. Thermal 2π-2π cycloaddition is a rare reaction that starts in the singlet state and proceeds through a triplet intermediate forming an energetically stable 4 membered ring in the singlet state. This reaction involves two changes in spin state and thus two spin-crossover transitions...
May 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28548626/correlates-of-protection-for-inactivated-enterovirus-71-vaccine-the-analysis-of-immunological-surrogate-endpoints
#4
Wenbo Zhu, Pengfei Jin, Jing-Xin Li, Feng-Cai Zhu, Pei Liu
BACKGROUND: Inactivated Enterovirus 71 (EV71) vaccines showed significant efficacy against the diseases associated with EV71 and a neutralizing antibody (NTAb) titer of 1:16-1:32 was suggested as the correlates of the vaccine protection. This paper aims to further estimate the immunological surrogate endpoints for the protection of inactivated EV71 vaccines and the effect factors. METHOD: Pre-vaccination NTAb against EV71 at baseline (day 0), post-vaccination NTAb against EV71 at day 56, and the occurrence of laboratory-confirmed EV71-associated diseases during a 24-months follow-up period were collected from a phase 3 efficacy trial of an inactivated EV71 vaccine...
May 26, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28548509/ultrafast-reversal-of-the-ferroelectric-polarization
#5
R Mankowsky, A von Hoegen, M Först, A Cavalleri
We report on the demonstration of ultrafast optical reversal of the ferroelectric polarization in LiNbO_{3}. Rather than driving the ferroelectric mode directly, we couple to it indirectly by resonant excitation of an auxiliary high-frequency phonon mode with femtosecond midinfrared pulses. Because of strong anharmonic coupling between these modes, the atoms are directionally displaced along the ferroelectric mode and the polarization is transiently reversed, as revealed by time-resolved, phase-sensitive, second-harmonic generation...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548501/structure-and-properties-of-sodium-enneaborate-na2-b8o11-oh-4-%C3%A2-b-oh-3%C3%A2-2h2o
#6
Doinita Neiner, Yulia V Sevryugina, Larry S Harrower, David M Schubert
Millions of tons of sodium borates are used annually by global industries in diverse applications important to modern society. The Na2O-B2O3-H2O phase diagram in the 0-100 °C temperature range contains 13 unique hydrated crystalline sodium borates, including five important industrial products. Structures were previously reported for each of these except for that having the highest boron content, known as sodium enneaborate, Na4B18O29·11H2O or 2Na2O·9B2O3·11H2O (1). Here we report the single-crystal structure of 1, revealing the structural formula Na2[B8O11(OH)4]·B(OH)3·2H2O, and describe some of its properties and relationships to other sodium borates...
May 26, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28548367/sinularin-induces-oxidative-stress-mediated-g2-m-arrest-and-apoptosis-in-oral-cancer-cells
#7
Yung-Ting Chang, Chang-Yi Wu, Jen-Yang Tang, Chiung-Yao Huang, Chih-Chuang Liaw, Shih-Hsiung Wu, Jyh-Horng Sheu, Hsueh-Wei Chang
Soft corals-derived natural product, sinularin, was antiproliferative against some cancers but its effect and detailed mechanism on oral cancer cells remain unclear. The subject of this study is to examine the antioral cancer effects and underlying detailed mechanisms in terms of cell viability, oxidative stress, cell cycle analysis, and apoptosis analyses. In MTS assay, sinularin dose-responsively decreased cell viability of three oral cancer cells (Ca9-22, HSC-3, and CAL 27) but only little damage to oral normal cells (HGF-1)...
May 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28548305/development-and-validation-of-an-lc-ms-ms-method-to-quantify-lysergic-acid-diethylamide-lsd-iso-lsd-2-oxo-3-hydroxy-lsd-and-nor-lsd-and-identify-novel-metabolites-in-plasma-samples-in-a-controlled-clinical-trial
#8
Patrick C Dolder, Matthias E Liechti, Katharina M Rentsch
BACKGROUND: Lysergic acid diethylamide (LSD) is a widely used recreational drug. The aim of this study was to develop and validate a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantification of LSD, iso-LSD, 2-oxo-3-hydroxy LSD (O-H-LSD), and nor-LSD in plasma samples from 24 healthy subjects after controlled administration of 100 μg LSD in a clinical trial. In addition, metabolites that have been recently described in in vitro studies, including lysergic acid monoethylamide (LAE), lysergic acid ethyl-2-hydroxyethylamide (LEO), 2-oxo-LSD, trioxylated-LSD, and 13/14-hydroxy-LSD, should be identified...
May 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28548163/crystal-structure-of-aquifex-aeolicus-gene-product-aq1627-a-putative-phosphoglucosamine-mutase-reveals-a-unique-c-terminal-end-to-end-disulfide-linkage
#9
Upasana Sridharan, Seiki Kuramitsu, Shigeyuki Yokoyama, Thirumananseri Kumarevel, Karthe Ponnuraj
The Aq1627 gene from Aquifex aeolicus, a hyperthermophilic bacterium has been cloned and overexpressed in Escherichia coli. The protein was purified to homogeneity and its X-ray crystal structure was determined to 1.3 Å resolution using multiple wavelength anomalous dispersion phasing. The structural and sequence analysis of Aq1627 is suggestive of a putative phosphoglucosamine mutase. The structural features of Aq1627 further indicate that it could belong to a new subclass of the phosphoglucosamine mutase family...
May 26, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28548030/everolimus-inhibited-multiple-isoforms-of-udp-glucuronosyltransferases-ugts
#10
Zuo Du, Guang Wang, Yun-Feng Cao, Cui-Min Hu, Kun Yang, Yong-Zhe Liu, Chun-Ze Zhang, Wei-Hua Zhang, Zhi-Tu Zhu, Hong-Zhi Sun, Xiao-Yu Sun, Mo Hong, Zhong-Ze Fang
1. Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) and has been clinically utilized to prevent the rejection of organ transplants. This study aims to determine the inhibition of everolimus on the activity of phase II drug-metabolizing enzymes UDP-glucuronosyltransferases (UGTs). 2. The results showed that 100 uM of everolimus exerted more than 80% inhibition towards UGT1A1, -1A3, and -2B7. UGT1A3 and UGT2B7 were selected to elucidate the inhibition mechanism, and in silico docking showed that hydrogen bonds and hydrophobic interactions mainly contributed to the strong binding of everolimus towards the activity cavity of UGT1A3 and UGT2B7...
May 26, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28547999/a-long-term-self-managed-handwriting-intervention-for-people-with-parkinson-s-disease-results-from-the-control-group-of-a-phase-ii-randomized-controlled-trial
#11
Johnny Collett, Marloes Franssen, Charlotte Winward, Hooshang Izadi, Andy Meaney, Wala Mahmoud, Marko Bogdanovic, Martin Tims, Derick Wade, Helen Dawes
OBJECTIVE: To report on the control group of a trial primarily designed to investigate exercise for improving mobility in people with Parkinson's disease (pwP). The control group undertook a handwriting intervention to control for attention and time spent practising a specific activity. DESIGN: Secondary analysis of a two-arm parallel phase II randomized controlled trial with blind assessment. SETTING: Community. PARTICIPANTS: PwP able to walk ⩾100 m and with no contraindication to exercise were recruited from the Thames Valley, UK, and randomized (1:1) to exercise or handwriting, via a concealed computer-generated list...
May 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28547751/education-and-process-change-to-improve-skin-health-in%C3%A2-a%C3%A2-residential-aged-care-facility
#12
Kay Price, Kate J Kennedy, Tabatha L Rando, Anthony R Dyer, Jo Boylan
We report on an intervention and evaluation in relation to changes in staff knowledge, time spent on healing and wound prevention and proportion of wounds in the facilities before and after. A rapid review of recent peer-reviewed literature (2006-2016) found 14 education-based intervention articles and provided the background and context for this intervention. A cohort of 164 nurses and personal care workers and 261 residents at two aged care-approved facilities contributed to this intervention on the effect of education, mentoring and practice change on staff knowledge and wound prevalence between 2015 and 2016...
May 26, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28547674/diagnostic-accuracy-of-various-modalities-relative-to-open-bone-biopsy-for-detection-of-long-bone-posttraumatic-osteomyelitis
#13
Vivek Chadayammuri, Benoit Herbert, Jiandong Hao, Andreas Mavrogenis, Juan C Quispe, Ji Wan Kim, Heather Young, Mark Hake, Cyril Mauffrey
BACKGROUND: Long bone posttraumatic osteomyelitis (PTOM) is a relatively common complication following surgical fixation of open fractures. There is a lacking consensus on ideal strategies for diagnostic evaluation of long bone PTOM. While open bone biopsy and culture is considered the 'gold diagnostic standard,' its cost and invasiveness are often prohibitive and have prompted the search for alternate diagnostic methods. OBJECTIVE: To evaluate the sensitivity and specificity of various diagnostic modalities relative to open bone biopsy and culture for the detection of long bone PTOM...
May 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28547525/neoadjuvant-chemotherapy-with-trastuzumab-docetaxel-and-carboplatin-administered-every-3%C3%A2-weeks-for-japanese-women-with-her2-positive-primary-breast-cancer-efficacy-and-safety
#14
Ikuko Sugitani, Shigeto Ueda, Takashi Sakurai, Takashi Shigekawa, Eiko Hirokawa, Hiroko Shimada, Hideki Takeuchi, Kazuo Matsuura, Misono Misumi, Nobuko Fujiuchi, Takao Takahashi, Takahiro Hasebe, Akihiko Osaki, Toshiaki Saeki
BACKGROUND: This phase II neoadjuvant study evaluated the efficacy and safety of a triweekly regimen of docetaxel and carboplatin in combination with trastuzumab (TCbH) in Japanese women with human epidermal growth factor receptor type2 (HER2)-positive primary breast cancer. METHODS: Patients with HER2-positive, stage I-III invasive breast cancer received six courses of trastuzumab (8 mg/kg loading dose, then 6 mg/kg, day 1), docetaxel (75 mg/m(2), day 1), and carboplatin (area under the curve: 6, day 1) every 3 weeks...
May 25, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28547184/combination-of-magnetic-dispersive-micro-solid-phase-extraction-and-supramolecular-solvent-based-microextraction-followed-by-high-performance-liquid-chromatography-for-determination-of-trace-amounts-of-cholesterol-lowering-drugs-in-complicated-matrices
#15
Somayeh Arghavani-Beydokhti, Maryam Rajabi, Alireza Asghari
A novel, efficient, rapid, simple, sensitive, selective, and environmentally friendly method termed magnetic dispersive micro solid-phase extraction combined with supramolecular solvent-based microextraction (Mdμ-SPE-SSME) followed by high-performance liquid chromatography (HPLC) with UV detection is introduced for the simultaneous microextraction of cholesterol-lowering drugs in complicated matrices. In the first microextraction procedure, using layered double hydroxide (LDH)-coated Fe3O4 magnetic nanoparticles, an efficient sample cleanup is simply and rapidly provided without the need for time-consuming centrifugation and elution steps...
May 26, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28546983/efficacy-of-purposeful-educational-workshop-of-medical-and-nonmedical-interventions-based-on-needs-assessments-in-nurses
#16
Abbas Attari, Mahin Aminoroaia, Mohammd Reza Maracy
BACKGROUND: The medical and nonmedical care of patients is the necessary skills in nursing profession. That it needs proper knowledge and attitude. Hence, it is important to promote nurses' knowledge and attitude by education based on need assessment. This study aimed to define the efficacy of a medical and nonmedical intervention educational workshop on nurses' knowledge and attitude until 3 months after holding the workshop in psychiatric wards of educational hospitals in Isfahan. MATERIALS AND METHODS: This is a quasi-experimental study...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546897/structural-properties-and-thermal-stability-of-cobalt-and-chromium-doped-%C3%AE-mno2-nanorods
#17
Romana Cerc Korošec, Polona Umek, Alexandre Gloter, Jana Padežnik Gomilšek, Peter Bukovec
α-MnO2 nanorods were synthesized via the hydrothermal decomposition of KMnO4 in an acidic environment in the presence of Co(2+) and Cr(3+) ions. Reactions were carried out at three different temperatures: 90, 130 and 170 °C. All prepared samples exhibit a tetragonal MnO2 crystalline phase. SEM-EDS analysis shows that cobalt cations are incorporated to a higher degree into the MnO2 framework than chromium ions, and that the content of the dopant ions decreases with increasing reaction temperature. The oxidation of Co(2+) to Co(3+) during the reaction was proved by an XANES study, while EXAFS results confirm that both dopant ions substitute Mn(4+) in the center of an octahedron...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28546882/in-situ-synthesis-of-a-magnetic-graphene-platform-for-the-extraction-of-benzimidazoles-from-food-samples-and-analysis-by-high-performance-liquid-chromatography
#18
Qianchun Zhang, Yulan Liu, Xingyi Wang, Huimin Li, Junyu Chen
A novel method was proposed for the determination of five benzimidazoles (oxfendazole, mebendazole, flubendazole, albendazole, and fenbendazole) using magnetic graphene (G-Fe3O4). G-Fe3O4 was synthesized via in situ chemical coprecipitation. The properties of G-Fe3O4 were characterized by various instrumental methods. G-Fe3O4 exhibited a great adsorption ability and good stability towards analytes. Various experimental parameters that might affect the extraction efficiency such as the amount of G-Fe3O4, extraction solvent, extraction time, and desorption conditions were evaluated...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28546807/isolation-of-biologically-active-peptides-from-the-venom-of-japanese-carpenter-bee-xylocopa-appendiculata
#19
Hiroko Kawakami, Shin G Goto, Kazuya Murata, Hideaki Matsuda, Yasushi Shigeri, Tomohiro Imura, Hidetoshi Inagaki, Tetsuro Shinada
BACKGROUND: Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfully applied to explore the venom peptides of a Japanese solitary carpenter bee, Xylocopa appendiculata (Hymenoptera: Apoidea: Apidae: Anthophila: Xylocopinae: Xylocopini). Although interesting biological effects of the crude venom of carpenter bees have been reported, the structure and biological function of the venom peptides have not been elucidated yet...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28546581/a-phase-1b-2b-multicenter-study-of-oral-panobinostat-plus-azacitidine-in-adults-with-mds-cmml-or-aml-with-%C3%A2-30-blasts
#20
G Garcia-Manero, M A Sekeres, M Egyed, M Breccia, C Graux, J D Cavenagh, H Salman, A Illes, P Fenaux, D J DeAngelo, R Stauder, K Yee, N Zhu, J-H Lee, D Valcarcel, A MacWhannell, Z Borbenyi, L Gazi, S Acharyya, S Ide, M Marker, O G Ottmann
Treatment with azacitidine (AZA), a demethylating agent, prolonged overall survival (OS) vs conventional care in patients with higher-risk myelodysplastic syndromes (MDS). As median survival with monotherapy is <2 years, novel agents are needed to improve outcomes. This phase 1b/2b trial (n=113) was designed to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of panobinostat (PAN) + AZA (phase 1b) and evaluate early efficacy and safety of PAN+AZA vs AZA monotherapy (phase 2b) in patients with higher-risk MDS, chronic myelomonocytic leukemia, or oligoblastic acute myeloid leukemia with <30% blasts...
May 26, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
keyword
keyword
6550
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"