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https://www.readbyqxmd.com/read/28727703/intrathecal-morphine-improves-hemodynamic-parameters-and-analgesia-in-patients-undergoing-aortic-valve-replacement-surgery-a-prospective-double-blind-randomized-trial
#1
Hamed Elgendy, Hatem A R Helmy
BACKGROUND: Intrathecal morphine (ITM) has been used in hopes of providing good postoperative analgesia in cardiac surgery. Little is known about its use in isolated aortic valve replacement surgery. OBJECTIVES: To evaluate the effects of 7 µ/kg ITM administration in aortic valve replacement in regards to hemodynamics, pain score, and postoperative complications when compared to general anesthesia alone. STUDY DESIGN: A randomized, double-blind trial...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28718248/outcome-of-0-2-glyceryltrinitrate-cream-versus-2-diltiazem-cream-in-the-treatment-of-chronic-anal-fissure
#2
Muhammad Siddique Khan, Ismail Akbar, Junaid Zeb, Salman Ahmad, Ajmal Khan
BACKGROUND: Anal fissure is a linear tear in the distal anal canal resulting from persistent hypertonia and spasm of the internal sphincter which results in mucosal ischemia. We have conducted a study in order to compare the outcome of 0.2% glyceryl trinitrate cream versus 2% diltiazem cream in the treatment of chronic anal fissure. METHODS: This randomized controlled trial (RCT) was carried out in the Department of Surgical "B" unit, at Ayub Teaching Hospital, Abbottabad, Pakistan from 15th June 2012 to 15th May 2015...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717722/gestational-trophoblastic-neoplasia-treatment-at-the-butaro-cancer-center-of-excellence-in-rwanda
#3
Ignace Nzayisenga, Roanne Segal, Natalie Pritchett, Mary J Xu, Paul H Park, Edgie V Mpanumusingo, Denis G Umuhizi, Donald P Goldstein, Ross S Berkowitz, Vedaste Hategekimana, Clemence Muhayimana, Fidel Rubagumya, Temidayo Fadelu, Neo Tapela, Tharcisse Mpunga, Rahel G Ghebre
PURPOSE: Gestational trophoblastic neoplasia (GTN) is a highly treatable disease, most often affecting young women of childbearing age. This study reviewed patients managed for GTN at the Butaro Cancer Center of Excellence (BCCOE) in Rwanda to determine initial program outcomes. PATIENTS AND METHODS: A retrospective medical record review was performed for 35 patients with GTN assessed or treated between May 1, 2012, and November 30, 2014. Stage, risk score, and low or high GTN risk category were based on International Federation of Gynecology and Obstetrics staging and the WHO scoring system and determined by beta human chorionic gonadotropin level, chest x-ray, and ultrasound per protocol guidelines for resource-limited settings...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28715608/ticagrelor-mitigates-ischemia-reperfusion-induced-vascular-endothelial-dysfunction-in-healthy-young-males-a-randomised-single-blinded-study
#4
Stefan Weisshaar, Brigitte Litschauer, Matthias Eipeldauer, Eva Luise Hobl, Michael Wolzt
AIM: Animal data suggest that ticagrelor but not clopidogrel protects against tissue injury. It is unclear if this effect of ticagrelor is also detectable in humans. We studied the effect of ticagrelor and clopidogrel at standard clinical doses on endothelial dysfunction in an experimental model of forearm vascular ischemia-reperfusion (IR) injury. METHODS: In a randomised, single-blinded trial 24 subjects underwent forearm blood flow (FBF) measurements in response to the endothelium-dependent vasodilator acetylcholine (ACh) and to glyceryltrinitrate (GTN; endothelium-independent) before and after a 20 min forearm ischemia...
July 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28692637/comparison-of-2-human-chorionic-gonadotropin-immunoassays-commercially-available-for-monitoring-patients-with-gestational-trophoblastic-disease
#5
Juliana Maria Quinalha de Souza, Antonio Braga, Rafael Sanches Dos Santos, Marcos Montanha Ramos, Rafael Cortés-Charry, Izildinha Maestá
OBJECTIVE: The aim of this study was to compare serum human chorionic gonadotropin (hCG) levels in patients with gestational trophoblastic disease (GTD) using 2 commercially available hCG immunoassays. METHODS: Serum samples were obtained from patients with GTD attending the Botucatu Medical School Trophoblastic Diseases Center of São Paulo State University (UNESP), from November 2014 to October 2015. Serum hCG levels were measured with both Architect i2000SR and Immulite 2000 XPi chemiluminescence assays...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28673447/bleeding-from-gestational-trophoblastic-neoplasia-embolotherapy-efficacy-and-tumour-response-to-chemotherapy
#6
Z Wang, X Li, J Pan, J Chen, H Shi, X Zhang, W Liu, N Yang, Z Jin, Y Xiang
AIM: To evaluate retrospectively the impact of selective arterial embolisation (SAE) on the prognosis of patients with gestational trophoblastic neoplasia (GTN). MATERIALS AND METHODS: A retrospective analysis of the records of all patients with GTN between January 2005 and January 2015 was performed. Forty-one patients (mean age, 28.9 ± 7.6 years) with massive vaginal haemorrhage from GTN (including 27 cases of choriocarcinoma and 14 cases of invasive mole) were treated with SAE...
June 30, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28647996/-curative-effects-and-influenced-factors-of-primary-chemotherapy-with-single-agent-methotrexate-on-low-risk-gestational-trophoblastic-neoplasia
#7
X D Wu, L L Chen, T Shen, S S Chen, Q Q Chen, J L Qin, Y F Fu, W G Lü
Objective: To evaluate the efficacy of primary chemotherapy with single-agent methotrexate (MTX) for low-risk gestational trophoblastic neoplasia and to analysis the influenced factors. Methods: We retrospectively reviewed 259 cases with low-risk gestational trophoblastic neoplasia whose primary chemotherapies were MTX 0.4 mg·kg(-1) (maximum 25 mg) daily for 5 days every other week. Patients' data between January 2001 and June 2015 was collected and the relationships of different factors to outcomes of chemotherapy were also evaluated...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28635985/experiences-of-women-with-gestational-trophoblastic-neoplasia-treated-with-high-dose-chemotherapy-and-stem-cell-transplantation-a-qualitative-study
#8
Kam Singh, Clare Warnock, Jane Ireson, Sarah Strickland, Delia Short, Michael J Seckl, Barry W Hancock
PURPOSE/OBJECTIVES: To explore the experiences of women with gestational trophoblastic neoplasia during and after treatment to understand their perspectives, priorities, and concerns.
. RESEARCH APPROACH: A descriptive, exploratory study using in-depth semistructured interviews.
. SETTING: All interviews were conducted in a quiet, designated room at Weston Park Hospital in Sheffield, South Yorkshire.
. PARTICIPANTS: Women with gestational trophoblastic neoplasia who had received stem cell transplantation from 2003 to 2013...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28629768/does-the-duration-of-symptoms-of-anal-fissure-impact-its-response-to-conservative-treatment-a-prospective-cohort-study
#9
Sameh Hany Emile, Hesham Elgendy, Hossam Elfeki, Alaa Magdy, Ahmed Aly Abdelmawla, Mahmoud Abdelnaby, Wael Khafagy
BACKGROUND: Conservative treatment is the first line of treatment for anal fissure. The current study aimed to evaluate the impact of symptom duration on the response of anal fissure to conservative treatment. PATIENTS AND METHODS: This prospective study was conducted on sixty patients with acute or chronic anal fissure who were treated conservatively with bulking agents, Sitz baths, and topical glyceryl trinitrate (GTN) 0.2%. Pain and constipation were assessed prior to treatment and at 6 weeks after therapy using visual analogue scale (VAS) and Wexner constipation score...
June 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28598453/effectiveness-of-0-2-glyceryl-trinitrate-and-0-5-nifedipine-in-the-treatment-of-chronic-anal-fissure
#10
S K Shrestha, P B Thapa, D K Maharjan, T Y Tamang
INTRODUCTION: Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal. This study aimed to assess the efficacy of Glyceryl Trinitrate and Nifedipine in the treatment of chronic anal fissure. METHODS: Ninety patients with symptomatic anal fissure in Kathmandu Medical College Teaching Hospital are allocated for study in two groups of 45 each from March 2013 to April 2014...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28591340/uterine-artery-doppler-flow-velocimetry-parameters-for-predicting-gestational-trophoblastic-neoplasia-after-complete-hydatidiform-mole-a-prospective-cohort-study
#11
Flavia Tarabini Castellani Asmar, Antonio Rodrigues Braga-Neto, Jorge de Rezende-Filho, Juliana Marques Simões Villas-Boas, Rafael Cortés Charry, Izildinha Maesta
OBJECTIVES: Doppler ultrasonography can be used to assess neoangiogenesis, a characteristic feature of postmolar gestational trophoblastic neoplasia. However, there is limited information on whether uterine artery Doppler flow velocimetry parameters can predict gestational trophoblastic neoplasia following a complete hydatidiform mole. The purpose of this study was as follows: 1) to compare uterine blood flow before and after complete mole evacuation between women who developed postmolar gestational trophoblastic neoplasia and those who achieved spontaneous remission, 2) to assess the usefulness of uterine Doppler parameters as predictors of postmolar gestational trophoblastic neoplasia and to determine the best parameters and cutoff values for predicting postmolar gestational trophoblastic neoplasia...
May 2017: Clinics
https://www.readbyqxmd.com/read/28588970/modifying-the-interagency-emergency-health-kit-to-include-treatment-for-non-communicable-diseases-in-natural-disasters-and-complex-emergencies
#12
Marcello Tonelli, Natasha Wiebe, Brian Nadler, Ara Darzi, Shahnawaz Rasheed
The Interagency Emergency Health Kit (IEHK) provides a standard package of medicines and simple medical devices for aid agencies to use in emergencies such as disasters and armed conflicts. Despite the increasing burden of non-communicable diseases (NCDs) in such settings, the IEHK includes few drugs and devices for management of NCDs. Using published data to model the population burden of acute and chronic presentations of NCDs in emergency-prone regions, we estimated the quantity of medications and devices that should be included in the IEHK...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28578274/synthesis-and-characterization-of-a-novel-organic-nitrate-ndhp-role-of-xanthine-oxidoreductase-mediated-nitric-oxide-formation
#13
Zhengbing Zhuge, Luciano L Paulo, Arghavan Jahandideh, Maria C R Brandão, Petrônio F Athayde-Filho, Jon O Lundberg, Valdir A Braga, Mattias Carlström, Marcelo F Montenegro
In this report, we describe the synthesis and characterization of 1,3-bis(hexyloxy)propan-2-yl nitrate (NDHP), a novel organic mono nitrate. Using purified xanthine oxidoreductase (XOR), chemiluminescence and electron paramagnetic resonance (EPR) spectroscopy, we found that XOR catalyzes nitric oxide (NO) generation from NDHP under anaerobic conditions, and that thiols are not involved or required in this process. Further mechanistic studies revealed that NDHP could be reduced to NO at both the FAD and the molybdenum sites of XOR, but that the FAD site required an unoccupied molybdenum site...
May 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/28567058/implementation-and-monitoring-of-a-gestational-trophoblastic-disease-management-program-in-a-tertiary-hospital-in-morocco-opportunities-and-challenges
#14
Imane Khachani, Mohamed Hassan Alami, Rachid Bezad
Objective. Gestational Trophoblastic Disease (GTD) management requires clear guidelines for diagnosis, treatment, and follow-up. Unequal management skills among practitioners, inadequate treatment, irregular surveillance, and drop-out are common in resource-limited settings and can lead to life-threatening complications and morbidities. To address these challenges, we implemented a GTD Management Program at the National Center for Reproductive Health in Rabat, Morocco. Methods and Program Description. In-depth review of management protocols was carried out, and concise guidelines were developed, with targeted training for physicians...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28559108/the-nitric-oxide-donor-rubpy-does-not-induce-in%C3%A2-vitro-cross-tolerance-with-acetylcholine
#15
Michele Paulo, Marcella D Grando, Roberto S da Silva, Richard D Minshall, Lusiane M Bendhack
PURPOSE: We have demonstrated that RuBPY induces hypotensive effect in hypertensive rats, promotes vasodilation at low concentrations, and presents low cytotoxicity. This study aimed to verify whether the NO donor RuBPY synthesized in our laboratory induces in vitro tolerance and cross-tolerance to acetylcholine (ACh) and sodium nitroprusside (SNP) in rat cava vein. METHODS: We compared the maximum relaxing effect (ME) and potency (pD2) of RuBPY and nitroglycerin (GTN) in cava vein rings...
May 27, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28534963/n-acetylglucosaminyltransferase-iva-promotes-invasion-of-choriocarcinoma
#16
Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa
Gestational trophoblastic neoplasia (GTN) results from the malignant transformation of placental trophoblasts which secrete human chorionic gonadotropin (hCG) as do normal placenta or hydatidiform mole. N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation of β1,4GlcNAc branches on the mannose core of N-glycans. Previous studies reported that β1,4GlcNAc branches on hCG were detected in GTN but not in normal pregnancy or hydatidiform mole. The aim of the present study was to understand the role of GnT-IVa in choriocarcinoma and find the target proteins for GnT-IVa glycosylation which contribute to the malignancy of choriocarcinoma...
May 23, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28498254/a-novel-prediction-model-for-postmolar-gestational-trophoblastic-neoplasia-and-comparison-with-existing-models
#17
Peng Zhao, Shuangyan Wang, Xiuli Zhang, Weiguo Lu
OBJECTIVE: The aim of this study was to comparatively study a novel model and existing models of predicting postmolar gestational trophoblastic neoplasia (GTN). METHODS: Two hundred twenty-two patients with complete hydatidiform moles were enrolled retrospectively. A natural regression was noted in 195 patients (spontaneous regression group), whereas the remaining 27 patients entered postmolar GTN (postmolar GTN group). The upper limits of the 95% confidence interval of human chorionic gonadotropin (hCG) values and hCG regression rates were calculated aggregately from the spontaneous regression group...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498241/serum-human-chorionic-gonadotropin-normogram-for-the-detection-of-gestational-trophoblastic-neoplasia
#18
Yalcke Eysbouts, Rick Brouwer, Petronella Ottevanger, Leon Massuger, Fred Sweep, Chris Thomas, Antonius van Herwaarden
OBJECTIVE: The aim of this study was to develop a serum human chorionic gonadotropin (hCG) normogram for both uneventful complete and partial hydatidiform moles in the first-trimester ultrasound era. METHODS: An hCG normogram for both complete and partial hydatidiform moles was constructed, based on 639 patients with uneventful serum hCG regression after evacuation between 1990 and 2014. Serum hCG was measured by an in-house-developed radioimmunoassay, detecting both intact hCG and free β-subunit...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28491173/radiographically-occult-pulmonary-metastases-from-gestational-trophoblastic-neoplasia
#19
Tina Hong, Edward Hills, Maria Del Pilar Aguinaga
Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Computed tomography imaging of the lungs is ordered if lung lesions are noted on chest x-rays. However, understanding the limitations of chest x-rays is important for detecting smaller pulmonary lesions...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28489216/the-role-of-surgery-in-the-management-of-women-with-gestational-trophoblastic-disease
#20
Lana DE Lourdes Aguiar Lima, Lílian Padron, Raphael Câmara, Sue Yazaki Sun, Jorge Rezende, Antônio Braga
The Gestational Trophoblastic Disease includes an interrelated group of diseases originating from placental tissue, with distinct behaviors concerning local invasion and metastasis. The high sensitivity of the serial dosages of human chorionic gonadotrophin, combined with advances in chemotherapy treatment, have made gestational trophoblastic neoplasia curable, most often through chemotherapy. However, surgery remains of major importance in the management of patients with gestational trophoblastic disease, improving their prognosis...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
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