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https://www.readbyqxmd.com/read/28635985/experiences-of-women-with-gestational-trophoblastic-neoplasia-treated-with-high-dose-chemotherapy-and-stem-cell-transplantation-a-qualitative-study
#1
Kam Singh, Clare Warnock, Jane Ireson, Sarah Strickland, Delia Short, Michael J Seckl, Barry W Hancock
PURPOSE/OBJECTIVES: To explore the experiences of women with gestational trophoblastic neoplasia during and after treatment to understand their perspectives, priorities, and concerns.
. RESEARCH APPROACH: A descriptive, exploratory study using in-depth semistructured interviews.
. SETTING: All interviews were conducted in a quiet, designated room at Weston Park Hospital in Sheffield, South Yorkshire.
. PARTICIPANTS: Women with gestational trophoblastic neoplasia who had received stem cell transplantation from 2003 to 2013...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28629768/does-the-duration-of-symptoms-of-anal-fissure-impact-its-response-to-conservative-treatment-a-prospective-cohort-study
#2
Sameh Hany Emile, Hesham Elgendy, Hossam Elfeki, Alaa Magdy, Ahmed Aly Abdelmawla, Mahmoud Abdelnaby, Wael Khafagy
BACKGROUND: Conservative treatment is the first line of treatment for anal fissure. The current study aimed to evaluate the impact of symptom duration on the response of anal fissure to conservative treatment. PATIENTS AND METHODS: This prospective study was conducted on sixty patients with acute or chronic anal fissure who were treated conservatively with bulking agents, Sitz baths, and topical glyceryl trinitrate (GTN) 0.2%. Pain and constipation were assessed prior to treatment and at 6 weeks after therapy using visual analogue scale (VAS) and Wexner constipation score...
June 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28598453/effectiveness-of-0-2-glyceryl-trinitrate-and-0-5-nifedipine-in-the-treatment-of-chronic-anal-fissure
#3
S K Shrestha, P B Thapa, D K Maharjan, T Y Tamang
INTRODUCTION: Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal. This study aimed to assess the efficacy of Glyceryl Trinitrate and Nifedipine in the treatment of chronic anal fissure. METHODS: Ninety patients with symptomatic anal fissure in Kathmandu Medical College Teaching Hospital are allocated for study in two groups of 45 each from March 2013 to April 2014...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28591340/uterine-artery-doppler-flow-velocimetry-parameters-for-predicting-gestational-trophoblastic-neoplasia-after-complete-hydatidiform-mole-a-prospective-cohort-study
#4
Flavia Tarabini Castellani Asmar, Antonio Rodrigues Braga-Neto, Jorge de Rezende-Filho, Juliana Marques Simões Villas-Boas, Rafael Cortés Charry, Izildinha Maesta
OBJECTIVES: Doppler ultrasonography can be used to assess neoangiogenesis, a characteristic feature of postmolar gestational trophoblastic neoplasia. However, there is limited information on whether uterine artery Doppler flow velocimetry parameters can predict gestational trophoblastic neoplasia following a complete hydatidiform mole. The purpose of this study was as follows: 1) to compare uterine blood flow before and after complete mole evacuation between women who developed postmolar gestational trophoblastic neoplasia and those who achieved spontaneous remission, 2) to assess the usefulness of uterine Doppler parameters as predictors of postmolar gestational trophoblastic neoplasia and to determine the best parameters and cutoff values for predicting postmolar gestational trophoblastic neoplasia...
May 2017: Clinics
https://www.readbyqxmd.com/read/28588970/modifying-the-interagency-emergency-health-kit-to-include-treatment-for-non-communicable-diseases-in-natural-disasters-and-complex-emergencies
#5
Marcello Tonelli, Natasha Wiebe, Brian Nadler, Ara Darzi, Shahnawaz Rasheed
The Interagency Emergency Health Kit (IEHK) provides a standard package of medicines and simple medical devices for aid agencies to use in emergencies such as disasters and armed conflicts. Despite the increasing burden of non-communicable diseases (NCDs) in such settings, the IEHK includes few drugs and devices for management of NCDs. Using published data to model the population burden of acute and chronic presentations of NCDs in emergency-prone regions, we estimated the quantity of medications and devices that should be included in the IEHK...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28578274/synthesis-and-characterization-of-a-novel-organic-nitrate-ndhp-role-of-xanthine-oxidoreductase-mediated-nitric-oxide-formation
#6
Zhengbing Zhuge, Luciano L Paulo, Arghavan Jahandideh, Maria C R Brandão, Petrônio F Athayde-Filho, Jon O Lundberg, Valdir A Braga, Mattias Carlström, Marcelo F Montenegro
In this report, we describe the synthesis and characterization of 1,3-bis(hexyloxy)propan-2-yl nitrate (NDHP), a novel organic mono nitrate. Using purified xanthine oxidoreductase (XOR), chemiluminescence and electron paramagnetic resonance (EPR) spectroscopy, we found that XOR catalyzes nitric oxide (NO) generation from NDHP under anaerobic conditions, and that thiols are not involved or required in this process. Further mechanistic studies revealed that NDHP could be reduced to NO at both the FAD and the molybdenum sites of XOR, but that the FAD site required an unoccupied molybdenum site...
May 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/28567058/implementation-and-monitoring-of-a-gestational-trophoblastic-disease-management-program-in-a-tertiary-hospital-in-morocco-opportunities-and-challenges
#7
Imane Khachani, Mohamed Hassan Alami, Rachid Bezad
Objective. Gestational Trophoblastic Disease (GTD) management requires clear guidelines for diagnosis, treatment, and follow-up. Unequal management skills among practitioners, inadequate treatment, irregular surveillance, and drop-out are common in resource-limited settings and can lead to life-threatening complications and morbidities. To address these challenges, we implemented a GTD Management Program at the National Center for Reproductive Health in Rabat, Morocco. Methods and Program Description. In-depth review of management protocols was carried out, and concise guidelines were developed, with targeted training for physicians...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28559108/the-nitric-oxide-donor-rubpy-does-not-induce-in%C3%A2-vitro-cross-tolerance-with-acetylcholine
#8
Michele Paulo, Marcella D Grando, Roberto S da Silva, Richard D Minshall, Lusiane M Bendhack
PURPOSE: We have demonstrated that RuBPY induces hypotensive effect in hypertensive rats, promotes vasodilation at low concentrations, and presents low cytotoxicity. This study aimed to verify whether the NO donor RuBPY synthesized in our laboratory induces in vitro tolerance and cross-tolerance to acetylcholine (ACh) and sodium nitroprusside (SNP) in rat cava vein. METHODS: We compared the maximum relaxing effect (ME) and potency (pD2) of RuBPY and nitroglycerin (GTN) in cava vein rings...
May 27, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28534963/n-acetylglucosaminyltransferase-iva-promotes-invasion-of-choriocarcinoma
#9
Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa
Gestational trophoblastic neoplasia (GTN) results from the malignant transformation of placental trophoblasts which secrete human chorionic gonadotropin (hCG) as do normal placenta or hydatidiform mole. N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation of β1,4GlcNAc branches on the mannose core of N-glycans. Previous studies reported that β1,4GlcNAc branches on hCG were detected in GTN but not in normal pregnancy or hydatidiform mole. The aim of the present study was to understand the role of GnT-IVa in choriocarcinoma and find the target proteins for GnT-IVa glycosylation which contribute to the malignancy of choriocarcinoma...
May 23, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28498254/a-novel-prediction-model-for-postmolar-gestational-trophoblastic-neoplasia-and-comparison-with-existing-models
#10
Peng Zhao, Shuangyan Wang, Xiuli Zhang, Weiguo Lu
OBJECTIVE: The aim of this study was to comparatively study a novel model and existing models of predicting postmolar gestational trophoblastic neoplasia (GTN). METHODS: Two hundred twenty-two patients with complete hydatidiform moles were enrolled retrospectively. A natural regression was noted in 195 patients (spontaneous regression group), whereas the remaining 27 patients entered postmolar GTN (postmolar GTN group). The upper limits of the 95% confidence interval of human chorionic gonadotropin (hCG) values and hCG regression rates were calculated aggregately from the spontaneous regression group...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498241/serum-human-chorionic-gonadotropin-normogram-for-the-detection-of-gestational-trophoblastic-neoplasia
#11
Yalcke Eysbouts, Rick Brouwer, Petronella Ottevanger, Leon Massuger, Fred Sweep, Chris Thomas, Antonius van Herwaarden
OBJECTIVE: The aim of this study was to develop a serum human chorionic gonadotropin (hCG) normogram for both uneventful complete and partial hydatidiform moles in the first-trimester ultrasound era. METHODS: An hCG normogram for both complete and partial hydatidiform moles was constructed, based on 639 patients with uneventful serum hCG regression after evacuation between 1990 and 2014. Serum hCG was measured by an in-house-developed radioimmunoassay, detecting both intact hCG and free β-subunit...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28491173/radiographically-occult-pulmonary-metastases-from-gestational-trophoblastic-neoplasia
#12
Tina Hong, Edward Hills, Maria Del Pilar Aguinaga
Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Computed tomography imaging of the lungs is ordered if lung lesions are noted on chest x-rays. However, understanding the limitations of chest x-rays is important for detecting smaller pulmonary lesions...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28489216/the-role-of-surgery-in-the-management-of-women-with-gestational-trophoblastic-disease
#13
Lana DE Lourdes Aguiar Lima, Lílian Padron, Raphael Câmara, Sue Yazaki Sun, Jorge Rezende, Antônio Braga
The Gestational Trophoblastic Disease includes an interrelated group of diseases originating from placental tissue, with distinct behaviors concerning local invasion and metastasis. The high sensitivity of the serial dosages of human chorionic gonadotrophin, combined with advances in chemotherapy treatment, have made gestational trophoblastic neoplasia curable, most often through chemotherapy. However, surgery remains of major importance in the management of patients with gestational trophoblastic disease, improving their prognosis...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28488397/dietary-sodium-intake-relates-to-vascular-health-in-children-with-type-1-diabetes
#14
Jemma Anderson, Jennifer J Couper, Sarah Toome, Christine Mpundu-Kaambwa, Lynne C Giles, Roger Gent, Brian Coppin, Alexia S Peña
BACKGROUND AND OBJECTIVE: Children with type 1 diabetes (T1D) have vascular dysfunction and frequently struggle to adhere to dietary recommendations. Limited data exist for the vascular consequences of poor diet quality in children. We aimed to evaluate the association between dietary components and vascular function in children with T1D. METHODS: Cross-sectional study including 90 children (13.6 [3.5] years, 41 boys) with T1D. They had evaluation of dietary micro and macronutrients (Australian Child and Adolescent Eating Survey), vascular endothelial and smooth muscle function (flow-mediated dilatation and glyceryl trinitrate mediated dilatation [GTN], respectively), clinical and biochemical variables...
May 10, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28482228/classification-systems-in-gestational-trophoblastic-neoplasia-sentiment-or-evidenced-based
#15
REVIEW
V L Parker, A A Pacey, J E Palmer, J A Tidy, M C Winter, B W Hancock
The classification system for Gestational trophoblastic neoplasia (GTN) has proved a controversial topic for over 100years. Numerous systems simultaneously existed in different countries, with three main rival classifications gaining popularity, namely histological, anatomical and clinical prognostic systems. Until 2000, prior to the combination of the FIGO and WHO classifications, there was no worldwide consensus on the optimal classification system, largely due to a lack of high quality data proving the merit of one system over another...
May 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28479904/glyceryl-trinitrate-is-a-novel-inhibitor-of-quorum-sensing-in-pseudomonas-aeruginosa
#16
Hisham A Abbas, Moutaz A Shaldam
BACKGROUND: Targeting quorum sensing is an alternative approach to antibiotics.Targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth. As a result, emergence of resistance is avoided and the immune system can easily eradicate bacteria. OBJECTIVES: Investigation of the possible inhibition of quorum sensing-regulated virulence of Pseudomonas aeruginosa by glyceryltrinitrate. METHODS: The quorum sensing inhibiting activity of glyceryl trinitrate was assessed by inhibition of violacein production in Chromobacterium violaceum ATCC 12472...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28473205/salvage-chemotherapy-for-gestational-trophoblastic-neoplasia-utility-or-futility
#17
Kathleen G Essel, Amanda Bruegl, David M Gershenson, Lois M Ramondetta, R Wendel Naumann, Jubilee Brown
OBJECTIVE: To determine the efficacy of chemotherapy after failed initial treatment in patients with high risk gestational trophoblastic neoplasia (GTN). METHODS: We performed a retrospective IRB-approved chart review of all patients with GTN seen at a single institution from 1985 to 2015, including all patients who failed initial treatment. We summarized clinical characteristics with descriptive statistics and estimated progression-free survival (PFS) and overall survival (OS) with the Kaplan-Meier method...
May 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28468975/physiology-of-angina-and-its-alleviation-with-nitroglycerine-insights-from-invasive-catheter-laboratory-measurements-during-exercise
#18
Kaleab N Asrress, Rupert Williams, Timothy P Lockie, Muhammed Z Khawaja, Kalpa De Silva, Matthew Lumley, Tiffany Patterson, Satpal S Arri, Sana Ihsan, Howard Ellis, Antoine Guilcher, Brian R Clapp, Philip J Chowienczyk, Sven Plein, Divaka Perera, Michael Marber, Simon R Redwood
Background -The mechanisms governing exercise-induced angina and its alleviation by the most commonly used anti-anginal drug, nitroglycerine (GTN), are incompletely understood. The purpose of this study was to develop a method with which the effects of anti-anginal drugs could be evaluated invasively during physiological exercise to gain further understanding as to the clinical impact of angina and GTN. Methods -40 Patients (mean 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterisation via radial access and performed incremental exercise using a supine cycle ergometer...
May 3, 2017: Circulation
https://www.readbyqxmd.com/read/28462491/in-vitro-evaluation-of-combination-of-egcg-and-erlotinib-with-classical-chemotherapeutics-on-jar-cells
#19
Elçin Telli, Hatice Genç, Burcugül Altuğ Tasa, S Sinan Özalp, A Tansu Koparal
Gestational Trophoblastic Neoplasia (GTN) is a term used for a group of malignant gynecological tumors including choriocarcinoma. Low-risk neoplasias can be cured using single agents Methotrexate (MTX) and actinomycin-D (ACD), but in certain cases, decreased responsiveness and serious side effects occur. Therefore, researchers have been attempting to find new treatment modalities. One of the most popular way for increasing cancer patient survival rates is supporting treatment with adjuvant molecules or chemosensitizers...
May 1, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28461032/clinical-characteristics-and-prognosis-of-ultra-high-risk-gestational-trophoblastic-neoplasia-patients-a-retrospective-cohort-study
#20
Yujia Kong, Junjun Yang, Fang Jiang, Jun Zhao, Tong Ren, Jie Li, Xiaoyu Wang, Fengzhi Feng, Xirun Wan, Yang Xiang
OBJECTIVE: The gestational trophoblastic neoplasia (GTN) patients with the International Federation of Gynecology and Obstetrics (FIGO) score≥12 are defined as ultra high-risk GTN. This study aims to investigate the clinical characteristics, the treatment efficiency, and the prognosis of ultra high-risk GTN patients. METHODS: Between January 2002 and December 2015, medical record data of 143 GTN patients with FIGO score≥12 at Peking Union Medical College Hospital (PUMCH) were reviewed...
April 28, 2017: Gynecologic Oncology
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