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https://www.readbyqxmd.com/read/28079767/primary-gastric-choriocarcinoma-presenting-as-a-pregnancy-of-unknown-location
#1
Alyssa Larish, Amanika Kumar, Sarah Kerr, Carrie Langstraat
BACKGROUND: Pregnancy of unknown location presents a diagnostic challenge, in rare occasions leading to the diagnosis of malignancy. We describe a case of β-hCG-secreting nongestational primary gastric choriocarcinoma presenting as a pregnancy of unknown location. CASE: A 37-year-old woman, gravida 4 para 3013, presented with several days of vaginal bleeding and rising β-hCG level without ultrasound localization of pregnancy. The diagnosis of pregnancy of unknown location was made and methotrexate administered at a β-hCG level of 7,779 milli-international units/mL...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28050451/choriocarcinoma-in-ongoing-pregnancy-presenting-with-intracranial-metastasis
#2
Sujata Siwatch, Vanita Suri, Pooja Sikka, Neelam Aggarwal, Seema Chopra
Choriocarcinoma presents usually as persistent trophoblastic disease, with prognosis worsening with duration from antecedent pregnancy. We present a unique case of a woman with choriocarcinoma who presented in the third trimester of pregnancy with eclampsia. She was managed with magnesium sulphate and underwent a caesarean section. However, she developed seizures in the post-partum period that were further investigated and attributed to intracranial metastatic lesions of Gestational Trophoblastic Neoplasia (GTN)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28031354/intra-arterial-nitroglycerin-as-directed-acute-treatment-in-experimental-ischemic-stroke
#3
Michael E Maniskas, Jill M Roberts, Rebecca Trueman, Annastazia E Learoyd, Amanda Gorman, Justin F Fraser, Gregory J Bix
BACKGROUND: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitric Oxide in Stroke trial suggested that GTN has therapeutic benefit with acute (within 6 hours) transdermal systemic sustained release therapy. OBJECTIVE: To examine an alternative use of GTN as an acute therapy for ischemic stroke following successful recanalization...
December 28, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28029666/comparison-of-fissure-healing-and-the-incidence-of-headache-among-the-patients-treated-with-endo-and-perianal-application-of-0-2-glyceryl-trinitrate-for-chronic-anal-fissure
#4
M R Joshi, T P Bohara, S Rupakheti
INTRODUCTION: Chronic anal fissure is associated with significant morbidity and reduction in quality of life mostly in young healthy adults. Glyceryl Trinitrate, a most commonly used agent for treatment, is associated with incidence of headache causing discontinuation of treatment. There is belief that endoanal application instead of perianal is associated with lower incidence of headache. This study is to compare the incidence and severity of headache in between perianal and endoanal application of GTN ointment...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28027937/reduced-perfusion-in-systemic-sclerosis-digital-ulcers-both-fingertip-and-extensor-can-be-increased-by-topical-application-of-glyceryl-trinitrate
#5
M Hughes, T Moore, J Manning, J Wilkinson, G Dinsdale, C Roberts, A Murray, A L Herrick
OBJECTIVES: In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma. Our aim was to assess blood flow response to topical glyceryl trinitrate (GTN) compared to placebo in SSc DUs, looking for differences in pathophysiology between fingertip and extensor lesions. METHOD: This was a double-blind, randomised, crossover, placebo-controlled study. Sixteen (6 fingertip, 10 extensor) DUs were each studied twice (one day apart): once with GTN and once with placebo ointment...
December 24, 2016: Microvascular Research
https://www.readbyqxmd.com/read/28005701/effect-of-short-term-exercise-training-on-brain-derived-neurotrophic-factor-signaling-in-spontaneously-hypertensive-rats
#6
Alice Monnier, Philippe Garnier, Aurore Quirie, Nicolas Pernet, Céline Demougeot, Christine Marie, Anne Prigent-Tessier
OBJECTIVE: Decreased brain-derived neurotrophic factor (BDNF) level has been reported in the hippocampus of hypertensive rats. The present study explored whether brain neurons and/or endothelial cells are targeted by hypertension with respect to BDNF expression and the potential of physical exercise to cope with hypertension. METHODS: Physical exercise was induced in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats. The hippocampus of sedentary and exercised rats (n = 6 for each group) were used for western blots to assess proBDNF, mature BDNF (mBDNF), tropomyosin-related kinase B (TrkB), P-TrkB (TrkB phosphorylated at tyrosine 816), synaptophysin, endothelial nitric oxide synthase (eNOS) and eNOS phosphorylated at serine 1177 protein levels...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27983929/long-non-coding-rna-linc00261-suppresses-cell-proliferation-and-invasion-and-promotes-cell-apoptosis-in-human-choriocarcinoma
#7
Yinan Wang, Kai Xue, Yonghong Guan, Yuemei Jin, Shanshan Liu, Yichao Wang, Shuyan Liu, Ling Wang, Liyin Han
Choriocarcinoma is one of the gestational trophoblastic neoplasia (GTN) that originate in the chorionic villi and the extravillous trophoblast. Long non-coding RNA (lncRNA) is a type of non-protein-coding RNAs that have recently been implicated in human tumoriogenesis. The present study investigated the role of an lncRNA LINC00261 in the cell proliferation, metastasis and apoptosis in choriocarcinoma cell lines. The transcription level of lncRNA LINC00261 was significantly lower in choriocarcinoma tissues and in choriocrcinoma cell lines...
October 26, 2016: Oncology Research
https://www.readbyqxmd.com/read/27926561/percutaneous-posterior-tibial-nerve-stimulation-vs-perianal-application-of-glyceryl-trinitrate-ointment-in-the-treatment-of-chronic-anal-fissure-a-randomized-clinical-trial
#8
Jaime Ruiz-Tovar, Carolina Llavero
BACKGROUND: Current therapeutic guidelines for the treatment of chronic anal fissure establish a medical approach as the first step. Glyceryl trinitrate ointment is the most popular of the available topical treatments in Spain but it is associated with the appearance of headache. OBJECTIVE: The purpose of this study was to compare the compliance rate among patients receiving glyceryl trinitrate treatment for chronic anal fissure with that among patients receiving percutaneous posterior tibial nerve stimulation...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27900108/high-dose-chemotherapy-with-autologous-peripheral-blood-stem-cell-transplantation-for-choriocarcinoma-a-case-report-and-literature-review
#9
Eiko Yamamoto, Kaoru Niimi, Kayo Fujikake, Tetsuya Nishida, Makoto Murata, Ayako Mitsuma, Yuichi Ando, Fumitaka Kikkawa
Choriocarcinoma is a malignant gestational trophoblastic neoplasia (GTN) and one of the curable types of gynecological cancer. However, 10% of choriocarcinoma patients have a poor prognosis, particularly when they have metastasis, apart from pulmonary metastasis, or do not go into remission by the second chemotherapeutic regimen. We herein present the case of a 36-year-old patient who had choriocarcinoma with metastases to the lungs, liver and kidneys. The 5th and 6th regimens with cisplatin for choriocarcinoma failed and the patient developed brain metastases...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27899973/expression-patterns-of-maspin-and-mutant-p53-are-associated-with-the-development-of-gestational-trophoblastic-neoplasia
#10
Pengming Sun, Qibin Wu, Guanyu Ruan, Xiu Zheng, Yiyi Song, Jianfan Zhun, Lixiang Wu, Walter H Gotlieb
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GTN from HMs. The current study evaluated the expression of maspin and tumor protein p53 (p53) in GTD, and their role in predicting the development of GTN...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899434/development-of-cgrp-dependent-pain-and-headache-related-behaviours-in-a-rat-model-of-concussion-implications-for-mechanisms-of-post-traumatic-headache
#11
Dara Bree, Dan Levy
BACKGROUND AND OBJECTIVE: Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies...
November 29, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27896261/giant-invasive-mole-presenting-as-a-cause-of-abdominopelvic-mass-in-a-perimenopausal-woman-an-unusual-presentation-of-a-rare-pathology
#12
Alpaslan Akyol, Memet Şimşek, Özlem Üçer
Invasive mole is a benign gestational trophoblastic disease that arises from the myometrial invasion of any gestational event via direct extension through tissue or vascular structures. Invasive mole (and other gestational trophoblastic diseases) may present with life-threatening complications including uterine perforation, excessive bleeding, acute hemoperitoneum, and abdominal pain. We report a case of invasive mole presenting as abdominal distention in a 51-year-old perimenopausal woman (gravida 12, para 12, abortion 0)...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27893465/accelerated-resolution-of-inflammation-underlies-sex-differences-in-inflammatory-responses-in-humans
#13
Krishnaraj S Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S Khambata, Umme Siddique, Saima Khan, Sven Van Eijl, Lorna C Gee, Jascharanpreet Bansal, Kavi Pitrola, Christopher Shaw, Fulvio D'Acquisto, Romain A Colas, Federica Marelli-Berg, Jesmond Dalli, Amrita Ahluwalia
BACKGROUND: Cardiovascular disease occurs at lower incidence in premenopausal females compared with age-matched males. This variation may be linked to sex differences in inflammation. We prospectively investigated whether inflammation and components of the inflammatory response are altered in females compared with males. METHODS: We performed 2 clinical studies in healthy volunteers. In 12 men and 12 women, we assessed systemic inflammatory markers and vascular function using brachial artery flow-mediated dilation (FMD)...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27885499/the-effects-of-alpha-1-adrenoceptor-blockade-and-angiotensin-converting-enzyme-inhibition-on-central-and-brachial-blood-pressure-and-vascular-reactivity-the-doxazosin-ramipril-study
#14
Andreas Jekell, Majid Kalani, Thomas Kahan
We aimed to study whether inhibition of the renin-angiotensin-aldosterone system has effects on vascular structure and function beyond the effects on blood pressure reduction alone. Patients with mild-to-moderate hypertension (n = 61, age 54 ± 12 years, 34% women) received the angiotensin converting enzyme inhibitor ramipril 10 mg or the alpha 1-adrenoceptor blocker doxazosin 8 mg double-blind for 12 weeks. Aortic blood pressure, pulse wave velocity, and augmentation index were assessed by applanation tonometry...
November 24, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27873224/therapeutic-potential-of-transdermal-glyceryl-trinitrate-in-the-management-of-acute-stroke
#15
Jason P Appleton, Nikola Sprigg, Philip M Bath
The nitric oxide donor, glyceryl trinitrate (GTN), is a candidate treatment for the management of acute stroke with haemodynamic and potential reperfusion and neuroprotective effects. When administered as a transdermal patch during the acute and subacute phases after stroke, GTN was safe, lowered blood pressure, maintained cerebral blood flow, and did not induce cerebral steal or alter functional outcome. However, when given within 6 h of stroke onset, GTN reduced death and dependency (odds ratio 0.52; 95% confidence interval 0...
November 21, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27866934/pharmacodynamic-action-and-mechanism-of-du-liang-soft-capsule-a-traditional-chinese-medicine-capsule-on-treating-nitroglycerin-induced-migraine
#16
Min Hou, Qing Tang, Qiang Xue, Xiaona Zhang, Yang Liu, Sheng Yang, Liechun Chen, Xiaoyu Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Du Liang soft capsule (DL) is a traditional Chinese medicine for treating migraines; it is made from two Chinese herbs, including LigusticumstriatumDC., root; Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., root. AIM OF THE STUDY: In the present study, we aimed to elucidate the pharmacodynamic action of DL and its mechanism in an animal model of migraines induced by glyceryl trinitrate (GTN). MATERIALS AND METHODS: Sixty rats were randomly divided into six groups, including a normal control group, model control group, positive group (Sumatriptan 0...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27865190/effect-of-potassium-supplementation-on-vascular-function-a-meta-analysis-of-randomized-controlled-trials
#17
Xixiang Tang, Bingyuan Wu, Yanting Luo, Long Peng, Yanming Chen, Jieming Zhu, Chaoquan Peng, Suhua Li, Jinlai Liu
BACKGROUND: Effects of potassium supplementation on vascular function remain conflicting. This meta-analysis aimed to summarized current literature to fill the gaps in knowledge. METHODS: A literature search was performed on PubMed database through April, 2016. The measurements of vascular function included pulse wave velocity (PWV), augmentation index (AI), pulse pressure (PP), flow mediated dilatation (FMD), glycerol trinitrate responses (GTN), and intercellular cell adhesion molecule-1 (ICAM-1)...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27821978/gestational-trophoblastic-neoplasia-experience-from-a-tertiary-care-center-of-india
#18
Ansar Hussain, Sheikh Aejaz Aziz, Gul Mohd Bhatt, A R Lone, Hk Imran Hussain, Burhan Wani, Nadeem Qazi
AIMS: Gestational trophoblastic neoplasia (GTN) comprise a spectrum of interrelated conditions originating from the placenta. With sensitive assays for human chorionic gonadotropin (β-hCG) and current approaches to chemotherapy, most women with GTN can be cured with preservation of reproductive potential. The purpose of this analysis was to address the outcome of GTN in patients from a tertiary care center of India. MATERIALS AND METHODS: We undertook a retrospective and prospective review of GTN cases treated at our center over a period of 7 years from 2008 to 2014...
December 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27816248/are-different-methotrexate-regimens-as-first-line-therapy-for-low-risk-gestational-trophoblastic-neoplasia-more-cost-effective-than-the-dactinomycin-regimen-used-in-gog-0174
#19
Caela R Miller, Nicole P Chappell, Caitlin Sledge, Charles A Leath, Neil T Phippen, Laura J Havrilesky, Jason C Barnett
OBJECTIVES: Gynecologic Oncology Group (GOG) 0174 compared weekly intramuscular methotrexate (MTX) with biweekly pulsed intravenous dactinomycin (Act-D) as single-agent chemotherapy for low-risk gestational trophoblastic neoplasia (GTN). Act-D had a higher rate of initial complete response (CR) (70% vs. 53%, p=0.01), but multi-day regimens of MTX have higher historic success rates. We assessed the cost-effectiveness of Act-D vs. MTX per GOG 0174 and explored multi-day MTX regimens. METHODS: A cost effectiveness decision model was constructed with data from GOG 0174...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27802359/antihypertensive-withdrawal-for-the-prevention-of-cognitive-decline
#20
REVIEW
Susan Jongstra, Jennifer K Harrison, Terry J Quinn, Edo Richard
BACKGROUND: Clinical trials and observational data have variously shown a protective, harmful or neutral effect of antihypertensives on cognitive function. In theory, withdrawal of antihypertensives could improve cerebral perfusion and reduce or delay cognitive decline. However, it is also plausible that withdrawal of antihypertensives may have a detrimental effect on cognition through increased incidence of stroke or other vascular events. OBJECTIVES: To assess the effects of complete withdrawal of at least one antihypertensive medication on incidence of dementia, cognitive function, blood pressure and other safety outcomes in cognitively intact and cognitive impaired adults...
1, 2016: Cochrane Database of Systematic Reviews
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