keyword
https://read.qxmd.com/read/38288188/intravenous-immunoglobulin-induced-transaminitis
#21
Aviraag Vijaya Prakash, Aparna Parvathaneni, Sarat Malempati, Gary Keilson
Intravenous immunoglobulin (IVIG) is a common therapeutic modality used in immune-mediated neuropathy. While the therapeutic benefits are well known, adverse reactions have been reported. One such adverse event, though rare, is transaminitis, which appears to be a transient and a self-limiting adverse reaction. Though most of the cases implicate the stabilizing agent to be the culprit, the exact mechanism is unknown. Thus far, it has been speculated that maltose, which has been commonly used as a stabilizer, is the cause of IVIG transaminitis...
December 2023: Curēus
https://read.qxmd.com/read/38283649/distinguishing-fibromyalgia-syndrome-from-small-fiber-neuropathy-a-clinical-guide
#22
JOURNAL ARTICLE
Sarah Jänsch, Dimitar Evdokimov, Nadine Egenolf, Caren Meyer Zu Altenschildesche, Luisa Kreß, Nurcan Üçeyler
INTRODUCTION: Fibromyalgia syndrome (FMS) and small fiber neuropathy (SFN) are distinct pain conditions that share commonalities and may be challenging as for differential diagnosis. OBJECTIVE: To comprehensively investigate clinical characteristics of women with FMS and SFN to determine clinically applicable parameters for differentiation. METHODS: We retrospectively analyzed medical records of 158 women with FMS and 53 with SFN focusing on pain-specific medical and family history, accompanying symptoms, additional diseases, and treatment...
January 2024: Pain Reports
https://read.qxmd.com/read/38245319/the-pathogenesis-of-painful-diabetic-neuropathy-and-clinical-presentation
#23
JOURNAL ARTICLE
Troels Staehelin Jensen
Diabetic neuropathy is a common complication of diabetes that affects up to 50% of patients during the course of the disease; 20-30% of the patients also develop neuropathic pain. The mechanisms underlying neuropathy are not known in detail, but both metabolic and vascular factors may contribute to the development of neuropathy. The development of the most common type of neuropathy is insidious, often starting distally in the toes and feet and gradually ascending up the leg and later also involving fingers and hands...
December 2023: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38241559/phenotypes-of-a-toddler-with-hereditary-sensory-and-autonomic-neuropathy-type-iv-comparing-with-normal-a-case-report
#24
JOURNAL ARTICLE
Qinghua Xu, Yanchun Wang, Yuantao Zhou, Lu Zhang, Xiaoyi Xiang, Yucheng Xie, Jiantian Lu, Lei Li, Ying Zhu, Zhao Zhang, Tiesong Zhang, Li Li
RATIONALE: Hereditary sensory and autonomic neuropathy type IV (HSAN IV) may be misdiagnosed because of low awareness among clinical professionals and overlap with other subtypes of congenital insensitivity to pain (CIP). PATIENT: The patient was a 1-year-and-5-months-old boy whose main symptoms were delayed psychomotor development and recurrent fever. Whole-exome sequencing (WES) revealed a compound heterozygous mutation (c. 1927C > T, c. 851-33T > A) in the NTRK1 gene of the child...
January 19, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38239958/automated-evaluation-of-parapapillary-choroidal-microvasculature-in-crowded-optic-discs-a-controlled-optical-coherence-tomography-angiography-study
#25
JOURNAL ARTICLE
Hatice Arda, Hidayet Sener, Ozge Temizyurek, Hatice Kubra Sonmez, Duygu Gulmez Sevim, Cem Evereklioglu, Fatih Horozoglu, Ayse Busra Gunay Sener
AIM: To compare superficial and deep vascular properties of optic discs between crowded discs and controls using optical coherence tomography angiography (OCT-A). METHODS: Thirty patients with crowded discs, and 47 control subjects were enrolled in the study. One eye of each individual was included and OCT-A scans of optic discs were obtained in a 4.5×4.5 mm2 rectangular area. Radial peripapillary capillary (RPC) density, peripapillary retinal nerve fiber layer (pRNFL) thickness, cup volume, rim area, disc area, cup-to-disc (c/d) area ratio, and vertical c/d ratio were obtained automatically using device software...
2024: International Journal of Ophthalmology
https://read.qxmd.com/read/38233122/protective-effect-of-alirocumab-a-pcsk9-inhibitor-on-the-sciatic-nerve-of-rats-with-diabetic-peripheral-neuropathy
#26
JOURNAL ARTICLE
Na Cui, Yonghao Feng, Ming Wang, Xiuyan Lu, Yongmei Huang, Yinghui Chen, Xiaohong Shi
Dyslipidemia has been considered a risk factor for diabetic peripheral neuropathy. Proprotein convertase subtilisin-like/Kexin 9 inhibitor (PCSK9) inhibitors are a new type of lipid-lowering drug currently in clinical use. The role of PCSK9 in diabetic peripheral neuropathy is still unclear. In this study, the effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve in rats with diabetic peripheral neuropathy and its underlying mechanisms were investigated. The diabetic peripheral neuropathy rat model was established by using a high-fat diet combined with streptozotocin injection, and experimental subjects were divided into normal, diabetic peripheral neuropathy, and alirocumab groups...
January 18, 2024: Endocrine Journal
https://read.qxmd.com/read/38226881/small-fiber-neuropathy-and-gadolinium-based-contrast-agents-no-association-found-in-rats
#27
EDITORIAL
Olivier Clement
No abstract text is available yet for this article.
January 2024: Radiology
https://read.qxmd.com/read/38226877/gadolinium-presence-in-rat-skin-assessment-of-histopathologic-changes-associated-with-small-fiber-neuropathy
#28
JOURNAL ARTICLE
Janina Boyken, Jessica Lohrke, Axel Treu, Joerg Neddens, Gregor Jost, Hannes-Friedrich Ulbrich, Thomas Balzer, Thomas Frenzel, Manuela Prokesch, Uwe Thuss, Hubertus Pietsch
Background The presence of gadolinium traces in the skin after administration of gadolinium-based contrast agents (GBCAs) raised safety concerns regarding a potential association with small fiber neuropathy (SFN). Purpose To investigate signs of SFN in rat foot pads by quantification of the intraepidermal nerve fiber density (IENFD) after multiple GBCA administrations and to evaluate gadolinium concentration, chemical species, and clearance. Materials and Methods Fifty rats received eight intravenous injections of either gadodiamide, gadobutrol, gadoterate, gadoteridol (8 × 0...
January 2024: Radiology
https://read.qxmd.com/read/38225894/interaction-of-human-keratinocytes-and-nerve-fiber-terminals-at-the-neuro-cutaneous-unit
#29
JOURNAL ARTICLE
Christoph Erbacher, Sebastian Britz, Philine Dinkel, Thomas Klein, Markus Sauer, Christian Stigloher, Nurcan Üçeyler
Traditionally, peripheral sensory neurons are assumed as the exclusive transducers of external stimuli. Current research moves epidermal keratinocytes into focus as sensors and transmitters of nociceptive and non-nociceptive sensations, tightly interacting with intraepidermal nerve fibers at the neuro-cutaneous unit. In animal models, epidermal cells establish close contacts and ensheath sensory neurites. However, ultrastructural morphological and mechanistic data examining the human keratinocyte-nerve fiber interface are sparse...
January 16, 2024: ELife
https://read.qxmd.com/read/38217609/a-homozygous-ndufs6-variant-associated-with-neuropathy-and-optic-atrophy
#30
JOURNAL ARTICLE
Andrea Gangfuß, Philipp Rating, Tomas Ferreira, Andreas Hentschel, Adela Della Marina, Heike Kölbel, Albert Sickmann, Angela Abicht, Florian Kraft, Tobias Ruck, Johann Böhm, Anne Schänzer, Ulrike Schara-Schmidt, Teresa M Neuhann, Rita Horvath, Andreas Roos
BACKGROUND: The NADH dehydrogenase [ubiquinone] iron-sulfur protein 6 (NDUFS6) gene encodes for an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Bi-allelic NDUFS6 variants have been linked with a severe disorder mostly reported as a lethal infantile mitochondrial disease (LMID) or Leigh syndrome (LS). OBJECTIVE: Here, we identified a homozygous variant (c.309 + 5 G >  A) in NDUFS6 in one male patient with axonal neuropathy accompanied by loss of small fibers in skin biopsy and further complicated by optic atrophy and borderline intellectual disability...
January 8, 2024: Journal of Neuromuscular Diseases
https://read.qxmd.com/read/38211845/reduced-gray-matter-volume-and-cortical-thickness-in-patients-with-small-fiber-neuropathy
#31
JOURNAL ARTICLE
Sebastian Scheliga, Maike F Dohrn, Ute Habel, Angelika Lampert, Roman Rolke, Annette Lischka, Noortje van den Braak, Marc Spehr, Han-Gue Jo, Thilo Kellermann
Small-fiber neuropathy (SFN) is defined by degeneration or dysfunction of peripheral sensory nerve endings. Central correlates have been identified on the level of gray matter volume (GMV) and cortical thickness (CT) changes. However, across SFN etiologies knowledge about a common structural brain signature is still lacking. Therefore, we recruited 26 SFN patients and 25 age- and sex-matched healthy controls (HC) to conduct voxel-based- and surface-based morphometry (VBM/SBM). Across all patients, we found reduced GMV in widespread frontal regions, left caudate, insula and superior parietal lobule...
January 9, 2024: Journal of Pain
https://read.qxmd.com/read/38197939/-neuropathic-pain-as-a-symptom-in-autonomic-neuropathies-and-other-rare-diseases-small-fiber-neuropathy-its-recognition-diagnosis-and-treatment
#32
REVIEW
Fiona Fischer, Maike F Dohrn, Romina Kapfenberger, Denver Igharo, Diana Seeber, Elena de Moya Rubio, Kalliopi Pitarokoili, Natalie Börsch, Martin Mücke, Roman Rolke, Jörg B Schulz, Andrea Maier
BACKGROUND: Neuropathic pain is difficult to diagnose and treat. Small fiber neuropathy (SFN) flies under the radar of nerve conduction studies. OBJECTIVES: The importance of a structured patient history and physical examination in the context of neuropathic pain is emphasized. Describing SFN as an important cause, the authors consider rare but partially treatable differential diagnoses. They conclude that autonomic symptoms are frequently associated, often presenting with diverse symptoms...
January 10, 2024: Der Schmerz
https://read.qxmd.com/read/38189534/studying-serum-neurofilamen-light-chain-levels-as-a-potential-new-biomarker-for-small-fiber-neuropathy
#33
JOURNAL ARTICLE
Panoraia Baka, Livia Steenken, Fabiola Escolano-Lozano, Falk Steffen, Aikaterini Papagianni, Claudia Sommer, Esther Pogatzki-Zahn, Silke Hirsch, Maria Protopapa, Stefan Bittner, Frank Birklein
BACKGROUND AND PURPOSE: Diagnosing small fiber neuropathies can be challenging. To address this issue, whether serum neurofilament light chain (sNfL) could serve as a potential biomarker of damage to epidermal Aδ- and C-fibers was tested. METHODS: Serum NfL levels were assessed in 30 patients diagnosed with small fiber neuropathy and were compared to a control group of 19 healthy individuals. Electrophysiological studies, quantitative sensory testing and quantification of intraepidermal nerve fiber density after skin biopsy were performed in both the proximal and distal leg...
January 8, 2024: European Journal of Neurology
https://read.qxmd.com/read/38176772/postural-orthostatic-tachycardia-syndrome-after-covid-19-vaccination
#34
JOURNAL ARTICLE
Debbie Lin Teodorescu, Anxhela Kote, Jewel N Reaso, Carine Rosenberg, Xiao Liu, Alan C Kwan, Susan Cheng, Peng-Sheng Chen
BACKGROUND: There is an association between coronavirus disease 2019 (COVID-19) mRNA vaccination and the incidence or exacerbation of postural orthostatic tachycardia syndrome (POTS). OBJECTIVE: The purpose of this study was to characterize patients reporting new or exacerbated POTS after receiving the mRNA COVID-19 vaccine. METHODS: We prospectively collected data from sequential patients in a POTS clinic between July 2021 and June 2022 reporting new or exacerbated POTS symptoms after COVID-19 vaccination...
January 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38170952/characterizing-acute-onset-small-fiber-neuropathy
#35
JOURNAL ARTICLE
Thierry Gendre, Jean-Pascal Lefaucheur, Tarik Nordine, Yasmine Baba-Amer, François-Jérôme Authier, Jérôme Devaux, Alain Créange
BACKGROUND AND OBJECTIVES: Immune-mediated small fiber neuropathy (SFN) is increasingly recognized. Acute-onset SFN (AOSFN) remains poorly described. Herein, we report a series of AOSFN cases in which immune origins are debatable. METHODS: We included consecutive patients with probable or definite AOSFN. Diagnosis of SFN was based on the NEURODIAB criteria. Acute onset was considered when the maximum intensity and extension of both symptoms and signs were reached within 28 days...
March 2024: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/38168650/prevalence-of-tinnitus-in-juvenile-fibromyalgia-patients-visiting-a-pediatric-rheumatology-clinic
#36
JOURNAL ARTICLE
Ayush Gupta, Kenneth Schikler
Juvenile fibromyalgia (JFMS) is a common disorder in the adolescent population with a prevalence of 1-6%. Our study looked at the prevalence of tinnitus in JFMS patients seen at a pediatric rheumatology clinic between 2016 and 2021. The objective of this study was to retrospectively assess prevalence of tinnitus and compare that with prevalence in non- JFMS patients presenting to the clinic. We also assessed prevalence of other sensory and pain symptoms, Widespread pain index >6 and abdominal pain in these two groups...
December 29, 2023: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/38156040/a-modelling-study-to-dissect-the-potential-role-of-voltage-gated-ion-channels-in-activity-dependent-conduction-velocity-changes-as-identified-in-small-fiber-neuropathy-patients
#37
JOURNAL ARTICLE
Anna Maxion, Ekaterina Kutafina, Maike F Dohrn, Pierre Sacré, Angelika Lampert, Jenny Tigerholm, Barbara Namer
OBJECTIVE: Patients with small fiber neuropathy (SFN) suffer from neuropathic pain, which is still a therapeutic problem. Changed activation patterns of mechano-insensitive peripheral nerve fibers (CMi) could cause neuropathic pain. However, there is sparse knowledge about mechanisms leading to CMi dysfunction since it is difficult to dissect specific molecular mechanisms in humans. We used an in-silico model to elucidate molecular causes of CMi dysfunction as observed in single nerve fiber recordings (microneurography) of SFN patients...
2023: Frontiers in Computational Neuroscience
https://read.qxmd.com/read/38123494/skin-innervation-across-amyotrophic-lateral-sclerosis-clinical-stages-new-prognostic-biomarkers
#38
JOURNAL ARTICLE
Maria Nolano, Vincenzo Provitera, Giuseppe Caporaso, Ines Fasolino, Ilaria Borreca, Annamaria Stancanelli, Valentina V Iuzzolino, Gianmaria Senerchia, Floriana Vitale, Stefano Tozza, Lucia Ruggiero, Rosa Iodice, Sergio Ferrari, Lucio Santoro, Fiore Manganelli, Raffaele Dubbioso
In the last decades, peripheral sensory abnormalities, including the evidence of cutaneous denervation, have been reported among the non-motor manifestations in amyotrophic lateral sclerosis (ALS). However, a correlation between cutaneous innervation and clinical features has not been found. Aims of this study were to assess sensory involvement by applying a morpho-functional approach on a large population of ALS patients stratified according to King's stages and to correlate these findings with the severity and prognosis of the disease...
December 20, 2023: Brain
https://read.qxmd.com/read/38116016/cytokines-profile-in-pure-neural-leprosy
#39
JOURNAL ARTICLE
Izabela Jardim R Pitta, Debora Bartzen Moraes Angst, Roberta Olmo Pinheiro, Joyce Soares da Silva Vieira, Clarissa Neves Spitz, Ligia Rocha Andrade, Larissa Bittencourt Carvalho, Mariana Andrea Hacker, Euzenir Nunes Sarno, Marcia Rodrigues Jardim
INTRODUCTION: Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood. OBJECTIVE: Describe the cytokines profile in patients with PNL. METHODS: 30 Patients diagnosed with PNL in the Souza Araujo Outpatient Clinic and with cytokines evaluated were selected. They were evaluated by neurologists and diagnosed after a nerve biopsy...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38112169/initial-validation-of-the-mass-general-neuropathy-exam-tool-magnet-for-evaluation-of-distal-small-fiber-neuropathy
#40
JOURNAL ARTICLE
Gary R Zirpoli, Khosro Farhad, Madeleine C Klein, Sean Downs, Max M Klein, Anne Louise Oaklander
INTRODUCTION/AIMS: Diagnosis of small-fiber neuropathy (SFN) is hampered by its subjective symptoms and signs. Confirmatory testing is insufficiently available and expensive, so predictive examinations have value. However, few support the 2020 SFN consensus-case-definition requirements or were validated for non-diabetes neuropathies. Thus we developed the Massachusetts General Hospital Neuropathy Exam Tool (MAGNET) and measured diagnostic performance in 160 symptomatic patients evaluated for length-dependent SFN from any cause and 37 healthy volunteers...
December 19, 2023: Muscle & Nerve
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