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Small fiber neuropathy

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https://www.readbyqxmd.com/read/29736880/comparison-of-peripheral-nerve-protection-between-insulin-based-glucose-control-and-alpha-lipoic-acid-ala-in-the-streptozotocin-stz-induced-diabetic-rat
#1
Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Jin
Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comparison to that of glucose control is unclear. In this study, we compared the neuroprotective potential of glucose control and ALA. Animals were divided into 6 groups based on the intervention used, as follows: normal, diabetes (DM), DM+racemic form of ALA, DM+R form of ALA, DM+once daily insulin glargine, and DM+once daily insulin glargine with twice daily insulin glulisine...
May 7, 2018: Endocrine
https://www.readbyqxmd.com/read/29706768/small-fiber-neuropathy-disease-classification-beyond-pain-and-burning
#2
REVIEW
Todd D Levine
Small fiber neuropathy (SFN) has a poorly understood pathology, but patients would benefit from determination of clinical phenotypes that allows for better diagnosis and treatment planning. I propose that patients should be classified dependent on whether there is sodium channel dysfunction, classic neurologic symptoms only, widespread neuropathic pain, or autonomic symptoms. Patients with SFN can then be considered in light of their clinical phenotype, allowing for focus on subsets of patients who might have diagnosable conditions or be more prone to responding to a particular type of therapy that may not be efficacious in the broader patient population with SFN...
2018: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/29690804/expression-of-macrophage-migration-inhibitory-factor-in-footpad-skin-lesions-with-diabetic-neuropathy
#3
Sun Up Noh, Won-Young Lee, Won-Serk Kim, Yong-Taek Lee, Kyung Jae Yoon
Background Diabetic neuropathy (DN) originating in distal lower extremities is associated with pain early in the disease course, overwhelming in the feet. However, the pathogenesis of DN remains unclear. Macrophage migration inhibitory factor (MIF) has been implicated in the onset of neuropathic pain and the development of diabetes. Objective of this study was to observe pain syndromes elicited in the footpad of DN rat model and to assess the contributory role of MIF in the pathogenesis of DN. Methods DN was made in SD rats by streptozotocin (STZ)...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29676840/behavioral-morphological-and-electrophysiological-assessment-of-the-effects-of-type-2-diabetes-mellitus-on-large-and-small-nerve-fibers-in-zucker-diabetic-fatty-rat-zucker-lean-and-wistar-rats
#4
E Garcia-Perez, T Schönberger, M Sumalla, B Stierstorfer, R Solà, H Doods, J Serra, N Gorodetskaya
BACKGROUND: Peripheral neuropathy is a common complication in type 2 diabetes mellitus (T2DM). The most common presentation is in the form of a distal axonal sensory-motor polyneuropathy that involves large and small nerve fibers in variable proportion. METHODS: Zucker Diabetic Fatty rats (ZDF), Zucker Lean (ZL) and Wistar Han (WH) rats were used to asses the behavioral, morphological and electrophysiological effects that T2DM have on peripheral large and small nerve fibers of 6-40 week-old rats...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29672450/downregulation-of-adenosine-and-adenosine-1-receptor-contributes-to-neuropathic-pain-in-resiniferatoxin-neuropathy
#5
Hung-Wei Kan, Chin-Hong Chang, Chih-Lung Lin, Yi-Chen Lee, Sung-Tsang Hsieh, Yu-Lin Hsieh
The neurochemical effects of adenosine signaling in small-fiber neuropathy leading to neuropathic pain are yet to be explored in a direct manner. This study examined this system at the level of ligand (via the ectonucleotidase activity of prostatic acid phosphatase, PAP) and adenosine A1 receptors (A1Rs) in resiniferatoxin (RTX) neuropathy, a peripheral neurodegenerative disorder which specifically affects nociceptive nerves expressing transient receptor potential vanilloid type 1 (TRPV1). We conducted immunohistochemistry on dorsal root ganglion neurons (DRG), high-performance liquid chromatography (HPLC) for functional assays, and pharmacological interventions to alter PAP and A1Rs in mice with RTX neuropathy...
April 16, 2018: Pain
https://www.readbyqxmd.com/read/29643833/-in-vivo-confocal-microscopic-evaluation-of-corneal-nerve-fibers-and-dendritic-cells-in-patients-with-beh%C3%A3-et-s-disease
#6
Gulfidan Bitirgen, Emine Tinkir Kayitmazbatir, Gunhal Satirtav, Rayaz A Malik, Ahmet Ozkagnici
Central and peripheral nervous system involvement may occur during the course of Behçet's disease (BD). In vivo corneal confocal microscopy (CCM) can detect corneal small fiber damage and immune cell density. The aim of this study was to assess central corneal sensitivity, corneal subepithelial nerve plexus morphology and dendritic cell (DC) density in patients with BD. Forty-nine consecutive patients with BD and 30 healthy control subjects were included in this cross-sectional study conducted at a tertiary referral university hospital...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29620599/small-fiber-neuropathy-in-a-pediatric-patient-following-anti-tnf-%C3%AE-therapy-for-ulcerative-colitis
#7
Jessica Breton, Benjamin Ellazam, Elie Haddad, Colette Deslandres
No abstract text is available yet for this article.
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29596948/what-is-the-best-strategy-on-detection-of-cornea-neuropathy-in-people-with-diabetes-recent-advances-in-potential-measurements
#8
REVIEW
Ying Lv, Shaozhen Zhao
There are well-acknowledged clinical or pre-clinical measurements concerning diabetic peripheral neuropathy(DPN). The current gold standard for diagnosis of diabetic peripheral neuropathy is nerve conduction suitable for detecting large nerve fiber function[1] and intraepidermal nerve fiber density assessment for small fiber damage evaluation[2]. The lack of a sensitive, non-invasive, and repeatable endpoint to measure changes in small nerve fibers is a major factor holding back clinical trials for the treatment of diabetic peripheral neuropathy...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29583067/neurofibromatous-neuropathy-an-ultrastructural-study
#9
Chiara Terracciano, Christa Pachatz, Emanuele Rastelli, Francesco Saverio Pastore, Mariarosa Anna Beatrice Melone, Roberto Massa
Plexiform neurofibroma is pathognomonic of neurofibromatosis 1 (NF1). An NF1-associated peripheral neuropathy has been described in a small minority of NF1 patients but its histopathological features are poorly characterized. We report the case of a 46-year-old woman presenting with bilateral supraclavicular painful masses without other stigmata of NF1. MRI showed bilateral plexiform lesions extending from cervical roots to the elbows. Nerve conduction studies documented a sensory motor polyneuropathy. Morphometric analysis of sural nerve biopsy showed a preferential loss of large-caliber myelinated fibers with a g ratio of 0...
March 27, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29553496/establishing-a-mouse-model-of-a-pure-small-fiber-neuropathy-with-the-ultrapotent-agonist-of-transient-receptor-potential-vanilloid-type-1
#10
Yi-Chen Lee, Shui-Chin Lu, Yu-Lin Hsieh
Patients with diabetes mellitus (DM) or those experiencing the neurotoxic effects of chemotherapeutic agents may develop sensation disorders due to degeneration and injury of small-diameter sensory neurons, referred to as small fiber neuropathy. Present animal models of small fiber neuropathy affect both large- and small-diameter sensory fibers and thus create a neuropathology too complex to properly assess the effects of injured small-diameter sensory fibers. Therefore, it is necessary to develop an experimental model of pure small fiber neuropathy to adequately examine these issues...
February 13, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29549285/corneal-nerve-fiber-size-adds-utility-to-the-diagnosis-and-assessment-of-therapeutic-response-in-patients-with-small-fiber-neuropathy
#11
Michael Brines, Daniel A Culver, Maryam Ferdousi, Martijn R Tannemaat, Monique van Velzen, Albert Dahan, Rayaz A Malik
Small fiber neuropathy (SFN) is a common feature of many inflammatory diseases, often presenting with pain and disability. SFN is diagnosed using symptoms, thermal threshold testing, and intra-epidermal nerve fiber quantification. Corneal confocal microscopy (CCM) is an ophthalmic imaging technique which non-invasively quantifies corneal nerve fiber (CNF) density, branch density and length, and has comparable diagnostic and superior ability to identify nerve regeneration compared to skin biopsy. CNF size (width and area) depends upon the number of fibers within each nerve, as well as pathology (e...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29549140/cd40-mediated-hif-1%C3%AE-expression-underlying-microangiopathy-in-diabetic-nerve-pathology
#12
Hung-Wei Kan, Jung-Hsien Hsieh, Hsiung-Fei Chien, Yea-Huey Lin, Ti-Yen Yeh, Chi-Chao Chao, Sung-Tsang Hsieh
To understand the pathology and molecular signatures of microangiopathy in diabetic neuropathy, we systemically and quantitatively examined the morphometry of microvascular and nerve pathologies of sural nerves. In the endoneurium of diabetic nerves, prominent microangiopathy was observed, as evidenced by reduced capillary luminal area, increased capillary basement membrane thickness and increased proportion of fibrin(+) blood vessels. Furthermore, capillary basement membrane thickness and the proportion of fibrin(+) blood vessels were correlated with small myelinated fiber density in diabetic nerves...
April 26, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29543981/somatotopic-heat-pain-thresholds-and-intraepidermal-nerve-fibers-in-health
#13
Jenny L Davies, Janean K Engelstad, Linde E Gove, Linda K Linbo, Rickey E Carter, Christopher Lynch, Nathan P Staff, Christopher J Klein, P James B Dyck, David N Herrmann, Peter J Dyck
INTRODUCTION: For sequential and somatotopic assessment of small fiber neuropathy, heat pain (HP) tests of hypoalgesia might be used instead of decreased counts of epidermal nerve fibers (ENFs), but then healthy subject reference values of HP thresholds are needed. METHODS: Using the Computer Assisted Sensation Evaluator IVc system, HP thresholds of hypoalgesia were estimated for 10 unilateral sites and counts of ENFs for 4 of them in healthy subjects. RESULTS: In healthy subjects, small but statistically significant differences of both HP thresholds of hypoalgesia and counts of ENFs were observed among tested sites...
March 15, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29542204/n-hexane-exposure-a-cause-of-small-fiber-neuropathy
#14
Raquel Guimarães-Costa, Yoland Schoindre, Arnaud Metlaine, Jean-Pascal Lefaucheur, Jean-Philippe Camdessanché, Thierry Maisonobe, Jean-Marc Léger
A 59-year-old woman presented with progressive paresthesias of all of her limbs for 4 years, associated with neuropathic pain, tingling in the tongue and allodynia, consistent with small fiber neuropathy (SFN). Several systemic symptoms and signs were found on clinical examination and laboratory work-up. Neurological investigations including neurophysiologic test and skin biopsy supported the diagnosis of SFN. Chronic exposure to N-hexane was then disclosed and suspected to be the cause of the disease. Following the discontinuation of chronic N-hexane exposure, the patient had a progressive improvement of all signs and symptoms, reinforcing the correlation between exposure to N-hexane, and development of SFN...
March 15, 2018: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29533926/reducing-cxcr4-mediated-nociceptor-hyperexcitability-reverses-painful-diabetic-neuropathy
#15
Nirupa D Jayaraj, Bula J Bhattacharyya, Abdelhak A Belmadani, Dongjun Ren, Craig A Rathwell, Sandra Hackelberg, Brittany E Hopkins, Herschel R Gupta, Richard J Miller, Daniela M Menichella
Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown. We hypothesize that chemokine CXCL12/CXCR4 signaling is central to this mechanism, as we have shown that CXCL12/CXCR4 signaling is necessary for the development of mechanical allodynia, a pain hypersensitivity behavior common in PDN...
April 23, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29518780/long-time-course-of-idiopathic-small-fiber-neuropathy
#16
Pia Flossdorf, Walter F Haupt, Anna Brunn, Martina Deckert, Gereon R Fink, Helmar C Lehmann, Gilbert Wunderlich
BACKGROUND: Small fiber neuropathy (SFN) is a challenging subtype of peripheral neuropathies. Once the diagnosis has been established, there is an uncertainty how SFN may progress, whether larger fibers will become involved over time, whether quality of life may be compromised, or whether repeated diagnostic workup in patients with unknown underlying cause may increase the yield of treatable causes of SFN. METHODS: We evaluated 16 patients with documented long-time course of idiopathic SFN...
March 8, 2018: European Neurology
https://www.readbyqxmd.com/read/29511692/quinolone-induced-painful-peripheral-neuropathy-a-case-report-and-literature-review
#17
Leonel J F Estofan, Stanislav Naydin, Gediminas Gliebus
We present a case report of a 20-year-old male with diabetes mellitus type 1, who developed severe painful peripheral neuropathy while on the second of a 10-day course with levofloxacin for the treatment of epididymitis. The intensity of the pain rapidly reached scores of 10/10 in a numeric scale 0/10, and the patient was transferred to an inpatient pain unit where he was treated aggressively with minimal improvement. A skin biopsy revealed small fiber neuropathy. Then the patient was treated with intravenous immunoglobulin, which improved the pain...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29493845/the-role-of-skin-biopsy-in-differentiating-small-fiber-neuropathy-from-ganglionopathy
#18
V Provitera, C H Gibbons, G Wendelschafer-Crabb, V Donadio, D F Vitale, A Loavenbruck, A Stancanelli, G Caporaso, R Liguori, N Wang, L Santoro, W R Kennedy, M Nolano
BACKGROUND AND PURPOSE: We aimed to test the clinical utility of the leg:thigh intraepidermal nerve-fiber (IENF) density ratio as a parameter to discriminate between length-dependent small-fiber neuropathy (SFN) and small-fiber sensory ganglionopathy (SFSG) in subjects with signs and symptoms of small-fiber pathology. METHODS: We retrospectively evaluated thigh and leg IENF density in 314 subjects with small-fiber pathology (173 with distal symmetrical length-dependent SFN and 141 with non-length-dependent SFSG)...
June 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29487016/-small-fiber-neuropathies-a-cause-of-great-concern-for-dermatologists
#19
EDITORIAL
L Misery
No abstract text is available yet for this article.
February 24, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29431174/small-fiber-neuropathy-presenting-during-the-antecedent-period-of-undifferentiated-arthritis-prior-to-rheumatoid-arthritis
#20
Julius Birnbaum
No abstract text is available yet for this article.
December 2017: Neurology. Clinical Practice
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