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Ali K Yetisen
Biohacking is a do-it-yourself citizen science merging body modification with technology. The motivations of biohackers include cybernetic exploration, personal data acquisition, and advocating for privacy rights and open-source medicine. The emergence of a biohacking community has influenced discussions of cultural values, medical ethics, safety, and consent in transhumanist technology.
March 14, 2018: Trends in Biotechnology
Michele Piazza, Francesco Squizzato, Chiara Chincarini, Marny Fedrigo, Chiara Castellani, Annalisa Angelini, Franco Grego, Michele Antonello
OBJECTIVE: The objective of this study was to perform a quantitative analysis and to identify predictors of embolic filter debris (EFD) load during carotid artery stenting (CAS) in asymptomatic patients. METHODS: All patients with asymptomatic carotid stenosis >70% undergoing CAS between 2008 and 2016 were included in a prospective database. A distal filter protection device was used in all patients. At the end of the procedure, the filter was fixed in formalin and then analyzed with a stereomicroscope...
March 1, 2018: Journal of Vascular Surgery
Adam W Hanley, Eric L Garland
Dispositional mindfulness (DM), or the tendency to attend to present moment experience, may have important implications for the structure of human personality. However, relationships between DM and the Big Five Model of Personality (BF) have not been definitively established. Therefore, the purpose of this meta-analysis was to extend previous investigations of the relationship between DM and the BF, utilizing a larger sample of studies, attending to relational inconsistencies potentially associated with alternative methods of operationalizing DM, conducting the first meta-analysis of the DM subdomains in relation to the BF, and situating the results in a cybernetic model...
December 2017: Mindfulness
M C Lardone, F Argandoña, M Lorca, A Piottante, M Flórez, C Palma, M Ebensperger, A Castro
STUDY QUESTION: Is the expression of steroidogenic enzyme 17α-Hydroxylase/17,20-Lyase (CYP17A1) downregulated in Leydig cells (LCs) of men with spermatogenic failure and compensated impairment of LC function i.e. a low testosterone to LH (T/LH) ratio? SUMMARY ANSWER: Although the transcriptional expression of CYP17A1 is increased, its protein expression is decreased, in isolated LCs of men with spermatogenic failure and reduced serum T/LH. WHAT IS KNOWN ALREADY: Primary spermatogenic defects have been associated with functional and morphological abnormalities of LCs, characterized by decreased serum testosterone (T) levels, decreased T/LH, increased 17β-estradiol (E2) and E2/T ratio, and larger clusters of LCs (LC hyperplasia)...
February 9, 2018: Molecular Human Reproduction
X Wang, X Shu, Z Li, W Huo, L Zou, Y Tang, L Li
BACKGROUND: Skin imaging analysis, acting as a supplement to noninvasive bioengineering devices, has been widely used in medical cosmetology and cosmetic product evaluation. The main aim of this study is to assess the differences and correlations in measuring skin spots, wrinkles, vascular features, porphyrin, and pore between two commercially available image analysis software. MATERIALS AND METHODS: Seventy healthy women were included in the study. Before taking pictures, the dermatologist evaluated subjects' skin conditions...
January 27, 2018: Skin Research and Technology
(no author information available yet)
No abstract text is available yet for this article.
January 12, 2018: Biological Cybernetics
Mitra Ghiasi, Afsaneh Shahrabi, Hasan Siamian
Background and purpose: Organization must keep current skills, abilities, and in the current field of competition, and move one step ahead of other competitors; for this purpose, must be a high degree of trust inside the organization. Cybernetic management is a new approach in management of organizations that its main task according to internal issues. This study aimed to investigate the relationship between cybernetics management and organizational trust among librarians of Mazandaran University of Medical Sciences...
December 2017: Acta Informatica Medica: AIM
Olena M Krekoten, Anatolii V Dereziuk, Olena V Ihnaschuk, Svitlana E Holovchanska
INTRODUCTION: Issues related to labour potential, its state and problems have consistently been a focus of attention for the International Labour Organisation (ILO). Its respective analysis shows that labour potential problems remain unresolved in many countries of the world. According to the World Health Organisation (WHO), adverse working conditions are among major factors of occupational disease development in Europe and the reason for disabilities of economically active population during 2...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Thomas W Grunt
Cancer-specific perturbations of signaling, metabolism, and epigenetics can be a cause and/or consequence of malignant transformation. Evidence indicates that these regulatory systems interact with each other to form highly flexible and robust cybernetic networks that promote malignant growth and confer treatment resistance. Deciphering these plexuses using holistic approaches known from systems biology can be instructive for the future design of novel anticancer strategies. In this review, I discuss novel findings elucidating the multiple molecular interdependence among cancer-specific signaling, cell metabolism, and epigenetics to provide an insightful understanding of how major cancer machineries interact with each other during cancer development and progression, and how this knowledge may be used for future co-targeting strategies...
February 2018: Trends in Endocrinology and Metabolism: TEM
Kui Young Park, Joon Hyuk Suh, Beom Joon Kim, Myeung Nam Kim, Chang Kwun Hong
Background: Onychomycosis is one of the most prevalent fungal diseases in the general population. However, treatment is of limited effectiveness and must be administered for long periods of time. Systemic antifungal agents are associated with adverse effects. Objective: We evaluated the clinical efficacy and safety of a 1,064-nm neodymium-doped yttrium aluminium garnet (Nd:YAG) laser with amorolfine nail lacquer to treat onychomycosis. Methods: The 128 patients were randomly divided to 2 groups: 64 in the experimental group were treated with 1,064-nm Nd:YAG laser therapy and amorolfine nail lacquer; the other 64 were in a control group treated with topical amorolfine lacquer monotherapy...
December 2017: Annals of Dermatology
Predrag Slijepcevic
Numerous studies in microbiology, eukaryotic cell biology, plant biology, biomimetics, synthetic biology, and philosophy of science appear to support the principles of the epistemological theory inspired by evolution, also known as "Evolutionary Epistemology", or EE. However, that none of the studies acknowledged EE suggests that its principles have not been formulated with sufficient clarity and depth to resonate with the interests of the empirical research community. In this paper I review evidence in favor of EE, and also reformulate EE principles to better inform future research...
January 2018: Bio Systems
Abraham M Shultz, Sangmook Lee, Mary Guaraldi, Thomas B Shea, Holly C Yanco
Background and Objective: The reductionist approach of neuronal cell culture has been useful for analyses of synaptic signaling. Murine cortical neurons in culture spontaneously form an ex vivo network capable of transmitting complex signals, and have been useful for analyses of several fundamental aspects of neuronal development hitherto difficult to clarify in situ. However, these networks lack the ability to receive and respond to sensory input from the environment as do neurons in vivo...
2017: Open Neurology Journal
Xue-Lai Luo, Da-Xing Xie, Jian-Xin Wu, An-Ding Wu, Zong-Qing Ge, Hai-Jie Li, Jun-Bo Hu, Zhi-Xin Cao, Jian-Ping Gong
AIM: To detect the existence of isolated cancer cells in the mesentery of colorectum (named as Metastasis V), and investigate its clinical significance in colorectal cancer (CRC) patients. METHODS: Sixty-three CRC patients who received radical excision between January 2012 and September 2015 were included. All the patients underwent laparoscopy-assisted radical colorectomy or proctectomy [with complete mesocolic excision (CME) or total mesorectal excision (TME)] with R0 dissections at the Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology...
September 14, 2017: World Journal of Gastroenterology: WJG
K Sankaran, Alex Hankey
Study of product diversity by companies and corporations led to the discovery of a new statistical distribution, the (1/f) distribution, assessed according to the Herfindahl-Hirschman index. Products of human creative thinking and decision-making seem to obey the index very widely or universally. This article explores examples of its applications in business and economics as evidence for a new scientific conjecture concerning the physiological basis of Mind: that mind functions from critical instabilities in the brain physiology...
September 19, 2017: Progress in Biophysics and Molecular Biology
David S Goldstein, Irwin J Kopin
In this review we describe a series of major concepts introduced during the past 150years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that hierarchical networks involving input-output relationships continuously orchestrate and learn adaptive patterns of observable behaviors, cognition, memory, mood, and autonomic systems. Taken together, these networks function as "good regulators" determining levels of internal variables and act as if there were homeostatic comparators ("homeostats")...
September 5, 2017: Autonomic Neuroscience: Basic & Clinical
Teodora O Nicolescu
The new approach of a patient-centred, appropriate and timely care that was at the heart of the Institute of Medicine (IOM) initiative is changing the face of the healthcare industry in general and, in particular, of anesthesiology as a speciality. The drivers of this change are better quality and decreased healthcare costs, since despite a large expenditure for healthcare, the quality of care has not changed tremendously. Metrics have been identified, derived from the cybernetic model first described by the quality "parent"...
April 2017: Romanian Journal of Anaesthesia and Intensive Care
Tim Bogg
Guided by cybernetic perspectives on personality, the present work used a representative sample of U.S. adults (N = 992) to examine Big Five personality traits and social and aging factors as predictors of social media network membership and past-month browsing/searching and profile updating among members. The results showed adults who were less extraverted and less neurotic and who reported greater physical limitations were less likely to be members. Moreover, extraverted adults without partners were more likely to be members than introverted adults without partners...
2017: Frontiers in Psychology
Frederike H Petzschner, Lilian A E Weber, Tim Gard, Klaas E Stephan
This article outlines how a core concept from theories of homeostasis and cybernetics, the inference-control loop, may be used to guide differential diagnosis in computational psychiatry and computational psychosomatics. In particular, we discuss 1) how conceptualizing perception and action as inference-control loops yields a joint computational perspective on brain-world and brain-body interactions and 2) how the concrete formulation of this loop as a hierarchical Bayesian model points to key computational quantities that inform a taxonomy of potential disease mechanisms...
September 15, 2017: Biological Psychiatry
Plamen L Simeonov, Andrée C Ehresmann
Forty-two years ago, Capra published "The Tao of Physics" (Capra, 1975). In this book (page 17) he writes: "The exploration of the atomic and subatomic world in the twentieth century has …. necessitated a radical revision of many of our basic concepts" and that, unlike 'classical' physics, the sub-atomic and quantum "modern physics" shows resonances with Eastern thoughts and "leads us to a view of the world which is very similar to the views held by mystics of all ages and traditions." This article stresses an analogous situation in biology with respect to a new theoretical approach for studying living systems, Integral Biomathics (IB), which also exhibits some resonances with Eastern thought...
June 8, 2017: Progress in Biophysics and Molecular Biology
Libor Pekař, Radek Matušů, Roman Prokop
Delay represents a significant phenomenon in the dynamics of many human-related systems-including biological ones. It has i.a. a decisive impact on system stability, and the study of this influence is often mathematically demanding. This paper presents a computationally simple numerical gridding algorithm for the determination of stability margin delay values in multiple-delay linear systems. The characteristic quasi-polynomial-the roots of which decide about stability-is subjected to iterative discretization by means of pre-warped bilinear transformation...
2017: PloS One
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