Gina M Many, James A Sanford, Tyler J Sagendorf, Zhenxin Hou, Pasquale Nigro, Katie L Whytock, David Amar, Tiziana Caputo, Nicole R Gay, David A Gaul, Michael F Hirshman, David Jimenez-Morales, Malene E Lindholm, Michael J Muehlbauer, Maria Vamvini, Bryan C Bergman, Facundo M Fernández, Laurie J Goodyear, Andrea L Hevener, Eric A Ortlund, Lauren M Sparks, Ashley Xia, Joshua N Adkins, Sue C Bodine, Christopher B Newgard, Simon Schenk
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism...
May 1, 2024: Nature metabolism