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https://www.readbyqxmd.com/read/29221682/effects-of-fructose-consumption-on-food-intake-and-biochemical-and-body-parameters-in-wistar-rats
#1
Viviane Wagner Ramos, Leandro Oliveira Batista, Kelse Tibau Albuquerque
INTRODUTION AND OBJECTIVE: Increased fructose consumption is associated with various metabolic changes that favor the onset of obesity and related comorbidities. The objective of this study was to assess the effects of chronic fructose consumption on body weight and adipose tissue, as well as on serum glucose and triglyceride levels. METHODS: Thirty-day-old Wistar rats were divided into two groups: fructose (F) and control (C), which had free access to commercial chow and either water or a 20% fructose solution...
December 5, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29220798/aegeline-inspired-synthesis-of-novel-amino-alcohol-and-thiazolidinedione-hybrids-with-antiadipogenic-activity-in-3t3-l1-cells
#2
Sabbu Satish, Ankita Srivastava, Pragya Yadav, Salil Varshney, Rakhi Choudhary, Vishal M Balaramnavar, Tadigoppula Narender, Anil Nilkanth Gaikwad
Excess adiposity is a hallmark of obesity, which is caused due to an imbalance between energy intake and energy consumed. Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, our group had reported natural product Aegeline (amino-alcohol) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipidemic compound. With this background, we synthesized a series of novel amino alcohol and thiazolidinedione hybrid molecules and studied their antiadipogenic activity...
November 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29216392/dioxin-like-pcb-126-increases-systemic-inflammation-and-accelerates-atherosclerosis-in-lean-ldl-receptor-deficient-mice
#3
Michael C Petriello, J Anthony Brandon, Jessie Hoffman, Chunyan Wang, Himi Tripathi, Ahmed Abdel-Latif, Xiang Ye, Xiangan Li, Liping Yang, Eun Lee, Sony Soman, Jazmyne Barney, Banrida Wahlang, Bernhard Hennig, Andrew J Morris
Exposure to dioxins and related persistent organic pollutants likely contributes to cardiovascular disease (CVD) risk through multiple mechanisms including the induction of chronic inflammation. Epidemiological studies have shown that leaner individuals may be more susceptible to the detrimental effects of lipophilic toxicants because they lack large adipose tissue depots that can accumulate and sequester these pollutants. This phenomenon complicates efforts to study mechanisms of pollutant-accelerated atherosclerosis in experimental animal models where high-fat feeding and adipose expansion limit the bioavailability of lipophilic pollutants...
December 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29210836/abdominal-fat-depots-and-subclinical-carotid-artery-atherosclerosis-in-women-with-and-without-hiv-infection
#4
Marshall J Glesby, David B Hanna, Donald R Hoover, Qiuhu Shi, Michael T Yin, Robert Kaplan, Phyllis C Tien, Mardge Cohen, Kathryn Anastos, Anjali Sharma
BACKGROUND: Data on associations between abdominal fat depot mass and subclinical atherosclerosis are limited, especially in women with HIV. METHODS: We assessed cross-sectional associations of dual X-ray absorptiometry scan-derived estimates of visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT) with 3 measures of subclinical carotid artery atherosclerosis-- carotid artery stiffness (Young's modulus of elasticity), presence of carotid artery lesions, and carotid artery intima-media thickness (cIMT)-- in a subsample of participants in the Women's Interagency HIV Study...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210643/adipokines-and-myokines-a-pivotal-role-in-metabolic-and-cardiovascular-disorders
#5
Hye Soo Chung, Kyung Mook Choi
Obesity induces an imbalance in the expression and secretion of several cytokines, which contributes to the development of metabolic and cardiovascular disorders. On the contrary, skeletal muscle is known to have a role in reversing the detrimental impact of obesity. It has been established that adipose tissue acts as an endocrine organ that secretes proinflammatory and anti-inflammatory adipokines. Similarly, skeletal muscle produces secretory molecules, called myokines, from contracting muscle fibers. Myokines were recently recognized as beneficial modulators of obesity, metabolic syndrome, and type 2 diabetes...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29209367/functional-characterization-of-preadipocytes-derived-from-human-periaortic-adipose-tissue
#6
Diana Vargas, Jaime Camacho, Juan Duque, Marisol Carreño, Edward Acero, Máximo Pérez, Sergio Ramirez, Juan Umaña, Carlos Obando, Albert Guerrero, Néstor Sandoval, Gina Rodríguez, Fernando Lizcano
Adipose tissue can affect the metabolic control of the cardiovascular system, and its anatomic location can affect the vascular function differently. In this study, biochemical and phenotypical characteristics of adipose tissue from periaortic fat were evaluated. Periaortic and subcutaneous adipose tissues were obtained from areas surrounding the ascending aorta and sternotomy incision, respectively. Adipose tissues were collected from patients undergoing myocardial revascularization or mitral valve replacement surgery...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29207395/adiponectin-and-its-receptors-are-differentially-expressed-in-human-tissues-and-cell-lines-of-distinct-origin
#7
Simon Jasinski-Bergner, Maximilian Büttner, Dagmar Quandt, Barbara Seliger, Heike Kielstein
BACKGROUND: Adiponectin is secreted by adipose tissue and exerts high abundance and an anti-inflammatory potential. However, only little information exists about the expression profiles of adiponectin and its recently identified receptor CDH13 in non-tumorous human tissues and their association to clinical parameters. METHODS: The expression levels of adiponectin and CDH13 were analyzed in heart, liver, kidney, spleen, skin, blood vessels, peripheral nerve and bone marrow of 21 human body donors, in 12 human cell lines, and in purified immune effector cell populations of healthy blood donors by immunohistochemistry, Western-blot, and semi-quantitative PCR...
December 6, 2017: Obesity Facts
https://www.readbyqxmd.com/read/29206988/group-based-trajectory-of-body-shape-from-ages-5-to-55-years-and-cardiometabolic-disease-risk-in-2-us-cohorts
#8
Yan Zheng, Mingyang Song, JoAnn E Manson, Edward L Giovannucci, Frank B Hu
The association of adiposity across the life span with cardiometabolic risk is not completely delineated. We used a group-based modeling approach to identify distinct trajectories of body shape from ages 5 years to 55 years among 84,792 women from the Nurses' Health Study (1976-2010) and 37,706 men from the Health Professionals Follow-up Study (1986-2010) and assessed the associations between these trajectories and incidence of type 2 diabetes and cardiovascular disease (CVD) during a 17-year follow-up period...
December 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29206648/relationship-between-plasma-protein-s-levels-and-apolipoprotein-c-ii-in-japanese-middle-aged-obese-women-and-young-nonobese-women
#9
Yukiko Otsuka, Maiko Ueda, Eri Nakazono, Tomohide Tsuda, Xiuri Jin, Kenta Noguchi, Shihoko Sata, Hitomi Miyazaki, Shimako Abe, Katsumi Imai, Masako Iwamoto, Takashi Masuda, Ririko Moriguchi, Shuji Nakano, Hiroko Tsuda
: Protein S, a nonenzymatic cofactor to activated protein C, presents in two forms in plasma, free form and in a complex with C4b-binding protein. The aim of this study was to determine the association of plasma protein S levels with the variables related to cardiovascular disease risk. The relationships between plasma protein S levels with lipids, inflammation markers, and adiposity were first examined on middle-aged obese women (n = 62), then on young nonobese women (n = 160) to verify the findings in the obese women...
December 4, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29202852/nutrition-education-for-cardiovascular-disease-prevention-in-individuals-with-spinal-cord-injuries-study-protocol-for-a-randomized-controlled-trial
#10
Jesse A Lieberman, Jacquelyn W McClelland, David C Goff, Elizabeth Racine, Michael F Dulin, William A Bauman, Janet Niemeier, Mark A Hirsch, H James Norton, Charity G Moore
BACKGROUND: Individuals with chronic spinal cord injuries (SCIs) have an increased prevalence of cardiovascular disease (CVD) and associated risk factors compared with age-matched control subjects. Exercise has been shown to improve selected CVD risk factors in individuals with SCI, but using nutrition education as an intervention has not been evaluated in this population. This paper describes our research plan for evaluating the effect of nutrition education on individuals with SCI. In the present study, called Eat Smart, Live Better, we are using a randomized controlled design to test an intervention adapted from an existing evidence-based program that showed a positive effect on nutrition knowledge and behavior of older adults from the general population...
December 4, 2017: Trials
https://www.readbyqxmd.com/read/29202751/walnut-consumption-in-a-weight-reduction-intervention-effects-on-body-weight-biological-measures-blood-pressure-and-satiety
#11
Cheryl L Rock, Shirley W Flatt, Hava-Shoshana Barkai, Bilge Pakiz, Dennis D Heath
BACKGROUND: Dietary strategies that help patients adhere to a weight reduction diet may increase the likelihood of weight loss maintenance and improved long-term health outcomes. Regular nut consumption has been associated with better weight management and less adiposity. The objective of this study was to compare the effects of a walnut-enriched reduced-energy diet to a standard reduced-energy-density diet on weight, cardiovascular disease risk factors, and satiety. METHODS: Overweight and obese men and women (n = 100) were randomly assigned to a standard reduced-energy-density diet or a walnut-enriched (15% of energy) reduced-energy diet in the context of a behavioral weight loss intervention...
December 4, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29197678/adipokines-inflammation-and-adiposity-in-hematopoietic-cell-transplant-survivors
#12
Tyler G Ketterl, Eric J Chow, Wendy M Leisenring, Pam Goodman, Ildi H Koves, Anna Petryk, Julia Steinberger, K Scott Baker
Adult survivors of acute leukemia in childhood have a higher than expected frequency of obesity, an increased risk for metabolic syndrome and early mortality from cardiovascular disease (CVD). Adipose tissue has been recognized as an endocrine and paracrine organ that secretes various adipokines involved in metabolic regulation and inflammatory processes. Examine inflammatory factors [IL-6 and TNF-] and adipokines (adiponectin, leptin) in addition to body composition and adiposity in cancer survivors who underwent hematopoietic cell transplantation (HCT) during childhood in comparison to sibling controls...
November 29, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29190710/the-association-between-depressive-symptoms-and-insulin-resistance-inflammation-and-adiposity-in-men-and-women
#13
M'Balu Webb, Melanie Davies, Nuzhat Ashra, Danielle Bodicoat, Emer Brady, David Webb, Calum Moulton, Khalida Ismail, Kamlesh Khunti
INTRODUCTION: Depression has been shown to be associated with elevated leptin levels, low-grade inflammation and insulin resistance. These derangements are often measured in mixed gender cohorts despite the different body compositions and hormonal environments of men and women and gender-specific prevalence and responses to depression. METHODS: A cross-sectional analysis was carried out on a cohort of 639 participants from the ADDITION-Leicester dataset to assess differences in markers of diabetes risk, cardiovascular risk and inflammation in depressed and non-depressed individuals...
2017: PloS One
https://www.readbyqxmd.com/read/29189132/polyphenols-novel-signaling-pathways
#14
Marie-Louise Ricketts, Bradley S Ferguson
BACKGROUND: Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a significant risk factor for the development of CVD. Non-alcoholic fatty liver disease (NAFLD), often referred to as the hepatic manifestation of MetS, is a constellation of progressive liver disorders closely linked to obesity, diabetes, and insulin resistance...
November 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29188817/dietary-sugar-intake-was-associated-with-increased-body-fatness-but-decreased-cardiovascular-mortality-in-chinese-elderly-an-11-year-prospective-study-of-mr-and-ms-os-hong-kong
#15
Z-M Liu, S L A Tse, D Chan, C Wong, Sy-S Wong
BACKGROUND/OBJECTIVES: Epidemiological studies suggest that sugar intake contributes to weight gain and increased risk of cardiovascular diseases (CVD). However, this association is largely undefined in the elderly population. Our aim was to investigate the effect of sugar consumption on the subsequent changes in body fatness and CVD mortality in Chinese elderly. METHODS: A total of 2000 men and 2000 women aged ⩾65 years were recruited from 2001 to 2003. Dietary sugar intake was estimated based on a validated 329-item food frequency questionnaire and a local sugar database...
November 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29185349/adipose-tissue-macrophage-polarization-in-cardiovascular-disease
#16
Martin Geiger, Sokrates Stein
No abstract text is available yet for this article.
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29184445/the-relation-of-cun-bae-index-and-bmi-with-body-fat-cardiovascular-events-and-diabetes-during-a-6-year-follow-up-the-hordaland-health-study
#17
Kathrine J Vinknes, Eha Nurk, Grethe S Tell, Gerhard Sulo, Helga Refsum, Amany K Elshorbagy
Objective: We compared Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) and body mass index (BMI) as correlates of body fat percent (BF%) and the association with future risk of cardiovascular disease (CVD) and type 2 diabetes in a Caucasian population. Methods: We used data from 6796 individuals (born 1925-27 and 1950-52) from the Hordaland Health Study, a prospective cohort study in Norway. The study was conducted in 1992-1993 and 1997-1999. Cross-sectional analyses were conducted with data from 1997/99, including BF% measured by dual-energy X-ray absorptiometry...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29180454/effect-of-sacubitril-valsartan-on-exercise-induced-lipid-metabolism-in-patients-with-obesity-and-hypertension
#18
Stefan Engeli, Rudi Stinkens, Tim Heise, Marcus May, Gijs H Goossens, Ellen E Blaak, Bas Havekes, Thomas Jax, Diego Albrecht, Parasar Pal, Uwe Tegtbur, Sven Haufe, Thomas H Langenickel, Jens Jordan
Sacubitril/valsartan (LCZ696), a novel angiotensin receptor-neprilysin inhibitor, was recently approved for the treatment of heart failure with reduced ejection fraction. Neprilysin degrades several peptides that modulate lipid metabolism, including natriuretic peptides. In this study, we investigated the effects of 8 weeks' treatment with sacubitril/valsartan on whole-body and adipose tissue lipolysis and lipid oxidation during defined physical exercise compared with the metabolically neutral comparator amlodipine...
November 27, 2017: Hypertension
https://www.readbyqxmd.com/read/29178290/microrna-21-contributes-to-reduced-microvascular-function-in-binge-drinking-young-adults
#19
Jing-Tan Bian, Mariann R Piano, Kumar U Kotlo, Abeer M Mahmoud, Shane A Phillips
BACKGROUND: Binge drinking is associated with increased risk for cardiovascular (CV) disease. MicroRNA-21 (miR21) is upregulated in the setting of excessive alcohol consumption and CV disease. Therefore, the goal of this study was to examine the vasodilatory responses to flow and acetylcholine in the absence and presence of an anti-miR21 inhibitor in the microcirculation of young adult repeated binge drinkers. METHODS: Gluteal subcutaneous adipose tissue biopsies were obtained from young adults (18-30 yrs, n = 35 vessels from binge drinkers [BDs] and n = 28 vessels from abstainers)...
November 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29177471/long-term-improvement-in-aortic-pulse-wave-velocity-after-weight-loss-can-be-predicted-by-white-adipose-tissue-factors
#20
Jesper Bäckdahl, Daniel P Andersson, Daniel Eriksson-Hogling, Kenneth Caidahl, Anders Thorell, Enrichetta Mileti, Carsten O Daub, Peter Arner, Mikael Rydén
Background: Arterial stiffness, measured by pulse wave velocity (PWV), is linked to obesity, cardiovascular disease and all-cause mortality. Short-term weight loss improves PWV, but the long-term effects are unknown. We investigated the effect of pronounced long-term weight loss on PWV and whether anthropometric/metabolic parameters and/or white adipose tissue (WAT) phenotype could predict this change in PWV. Methods: Eighty-two obese subjects were examined before and two years after Roux-en-Y gastric bypass...
November 21, 2017: American Journal of Hypertension
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