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https://www.readbyqxmd.com/read/29228169/endothelial-permeability-ldl-deposition-and-cardiovascular-risk-factors-a-review
#1
Santa Mundi, Marika Massaro, Egeria Scoditti, Maria Annunziata Carluccio, Victor W M van Hinsbergh, M Luisa Iruela-Arispe, Raffaele De Caterina
Early atherosclerosis features functional and structural changes in the endothelial barrier function that affect the traffic of molecules and solutes between the vessel lumen and the vascular wall. Such changes are mechanistically related to the development of atherosclerosis.Proatherogenic stimuli and cardiovascular risk factors, such as dyslipidemias, diabetes, obesity, and smoking, all increase endothelial permeability sharing a common signalling denominator: an imbalance in the production/disposal of reactive oxygen species (ROS), broadly termed oxidative stress...
December 8, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29227868/systemic-mastocytosis-associates-with-cardiovascular-events-despite-lower-plasma-lipid-levels
#2
Swasti Indhirajanti, Paul L A van Daele, Sven Bos, Monique T Mulder, Ilze Bot, Jeanine E Roeters van Lennep
BACKGROUND AND AIMS: Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls. METHODS: In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29226917/toward-research-tested-mobile-health-interventions-to-prevent-diabetes-and-cardiovascular-disease-among-persons-with-pre-diabetes
#3
Steven S Coughlin, Jessica Lynn Stewart
Background: About 35% of US adults have pre-diabetes and an increased risk of diabetes. Consumer-facing devices such as the Fitbit help users become more physically active and manage their weight which reduces risk of diabetes and cardiovascular disease. Methods: In this commentary we provide a summary of healthy lifestyle intervention studies involving persons with pre-diabetes including those conducted in routine clinical practice. We also provide an account of how such interventions might be enhanced through the use of wearable devices linked to smartphone applications...
November 2017: J Hosp Manag Health Policy
https://www.readbyqxmd.com/read/29226712/-risk-stratification-before-thoracic-surgery-perioperative-pulmonary-rehabilitation
#4
Attila Vágvölgyi, Zsolt Rozgonyi, Pál Vadász, János Tamás Varga
INTRODUCTION: Besides the oncology and operative surgical technics, functional aspects influence the operability of lung cancer. Preoperative risk stratification, evaluation of postoperative complications needs to be considered. AIM: To review international literature and experiences of our institute. METHOD: We focused the literature of risk stratification of thoracic surgery. Lung function, lung mechanics, chest kinematics, exercise physiology were considered...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29226105/non-alcoholic-fatty-liver-disease-a-clinical-update
#5
REVIEW
Joseph M Pappachan, Shithu Babu, Babu Krishnan, Nishal C Ravindran
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in developed countries because of the obesity epidemic. The disease increases liver-related morbidity and mortality, and often increases the risk for other comorbidities, such as type 2 diabetes and cardiovascular disease. Insulin resistance related to metabolic syndrome is the main pathogenic trigger that, in association with adverse genetic, humoral, hormonal and lifestyle factors, precipitates development of NAFLD...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29225702/the-influence-of-dopamine-beta-hydroxylase-and-catechol-o-methyltransferase-gene-polymorphism-on-the-efficacy-of-insulin-detemir-therapy-in-patients-with-type-2-diabetes-mellitus
#6
Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F Outeiro, Nela Pivac, Fran Borovecki
Background: Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic control. However, previous studies reported that insulin detemir is an efficient long-acting insulin with a weight sparing effect. The aim of this study was to determine the association of catechol O-methyltransferase (COMT) Val108/158Met and dopamine-beta-hydroxylase (DBH) 1021C/T polymorphisms with the effectiveness of insulin detemir in achieving glucose control and body weight control...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29225481/perspectives-on-high-intensity-interval-exercise-for-health-promotion-in-children-and-adolescents
#7
REVIEW
Bert Bond, Kathryn L Weston, Craig A Williams, Alan R Barker
Physical activity lowers future cardiovascular disease (CVD) risk; however, few children and adolescents achieve the recommended minimum amount of daily activity. Accordingly, there is virtue in identifying the efficacy of small volumes of high-intensity exercise for health benefits in children and adolescents for the primary prevention of CVD risk. The purpose of this narrative review is to provide a novel overview of the available literature concerning high-intensity interval-exercise (HIIE) interventions in children and adolescents...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29225327/plasma-fibrin-clot-structure-and-thromboembolism-clinical-implications
#8
Michał Ząbczyk, Anetta Undas
Fibrin formed as a result of fibrinogen polymerization is a main protein component of a clot in a test tube and intravascular thrombi in vivo. Fibrin clot structure characterized by fibers diameter and pore size differs between healthy subjects and those with thromboembolic diseases, in part due to the quality and quantity of fibrinogen and the magnitude of thrombin generation. A key measure of plasma clot structure is its permeability, reflected by the Darcy constant, Ks. Reduced Ks is a typical feature of the prothrombotic fibrin clot phenotype, which is associated with faster formation of denser fibrin mesh, relatively resistant to lysis...
December 11, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29225112/fisetin-a-bioactive-phytochemical-with-potential-for-cancer-prevention-and-pharmacotherapy
#9
REVIEW
Dharambir Kashyap, Ajay Sharma, Katrin Sak, Hardeep Singh Tuli, Harpal Singh Buttar, Anupam Bishayee
A wide variety of chronic diseases, such as neurodegenerative and cardiovascular disorders, diabetes mellitus, osteoarthtitis, obesity and various cancers, are now being treated with cost effective phytomedicines. Since synthetic medicines are very expensive, concerted efforts are being made in developing and poor countries to discover cost effective medicines for the treatment of non-communicable diseases (NCDs). Understanding the underlying mechanisms of bioactive medicines from natural sources would not only open incipient avenues for the scientific community and pharmaceutical industry to discover new drug molecules for the therapy of NCDs, but also help to garner knowledge for alternative therapeutic approaches for the management of chronic diseases...
December 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29225058/impact-of-comorbidities-on-functional-recovery-from-partial-nephrectomy
#10
Sudhir Isharwal, Wenda Ye, Alice Wang, Joseph Abraham, Joseph Zabell, Wen Dong, Jitao Wu, Chalairat Suk-Ouichai, Elvis R Caraballo, Tianming Gao, Steven C Campbell
PURPOSE: Preservation of parenchymal mass and ischemia type/duration can influence functional recovery after partial nephrectomy (PN). Some have hypothesized that relevant comorbidities may also impact nephron stability and functional recovery, but this has not been adequately investigated. MATERIALS/METHODS: 405 patients with PN at our center (2007-2015) had necessary data to determine function and parenchymal mass preserved within the ipsilateral kidney. Comorbidities potentially associated with renal functional status were reviewed, including various degrees of hypertension, diabetes, cardiovascular disease, obesity, smoking status, and use of related medications...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29224938/subclinical-atherosclerosis-in-pediatric-liver-transplant-recipients-carotid-and-aorta-intima-media-thickness-and-their-predictors
#11
Emily R Perito, Andrew Phelps, Tabitha Vase, Vickie A Feldstein, Robert H Lustig, Philip Rosenthal
OBJECTIVE: To investigate prevalence and predictors of cardiovascular risk in pediatric liver transplant recipients using noninvasive markers of subclinical atherosclerosis: carotid intima-media thickness (cIMT) and aorta intima-media thickness (aIMT). STUDY DESIGN: Cross-sectional study of 88 pediatric liver transplant recipients. The cIMT and aIMT were measured by ultrasound imaging using standardized protocol. RESULTS: Participants were 15...
December 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29224471/clinical-relevance-of-liver-histopathology-and-different-histological-classifications-of-nash-in-adults
#12
Fabio Nascimbeni, Stefano Ballestri, Mariana Verdehlho Machado, Alessandro Mantovani, Helena Cortez-Pinto, Giovanni Targher, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) encompasses simple steatosis and steatohepatitis (NASH) with or without fibrosis/cirrhosis and hepatocellular carcinoma. NAFLD occurs epidemically in most areas of the world, contributes to cardiovascular events and liver-related mortality and therefore exacts a major economic toll. Areas covered: Here we summarize what clinicians should know about NAFLD histopathology in adults. We report on the individual histological features and scoring systems of NAFLD: the NAFLD activity score (NAS) introduced by the NASH-Clinical Research Network, the "Fatty Liver Inhibition of Progression" algorithm and Steatosis, Activity, and Fibrosis (SAF) score...
December 11, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29224190/metabolic-surgery-for-the-treatment-of-type-2-diabetes-in-obese-individuals
#13
REVIEW
David E Cummings, Francesco Rubino
Several bariatric operations originally designed to promote weight loss have been found to powerfully treat type 2 diabetes, causing remission in most cases, through diverse mechanisms additional to the secondary consequences of weight loss. These observations have prompted consideration of such operations as 'metabolic surgery', used expressly to treat diabetes, including among patients who are only mildly obese or merely overweight. Large, long-term observational studies consistently demonstrate that bariatric/metabolic surgery is associated with reductions in all cardiovascular risk factors, actual cardiovascular events, microvascular diabetes complications, cancer and death...
December 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/29224098/role-of-estrogens-in-the-regulation-of-liver-lipid-metabolism
#14
Brian T Palmisano, Lin Zhu, John M Stafford
Before menopause, women are protected from atherosclerotic heart disease associated with obesity relative to men. Sex hormones have been proposed as a mechanism that differentiates this risk. In this review, we discuss the literature around how the endogenous sex hormones and hormone treatment approaches after menopause regulate fatty acid, triglyceride, and cholesterol metabolism to influence cardiovascular risk.The important regulatory functions of estrogen signaling pathways with regard to lipid metabolism have been in part obscured by clinical trials with hormone treatment of women after menopause, due to different formulations, routes of delivery, and pairings with progestins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224092/sex-differences-in-leptin-control-of-cardiovascular-function-in-health-and-metabolic-diseases
#15
Eric J Belin de Chantemèle
Leptin, the adipocyte-derived hormone identified in 1994 for its major role in the control of satiety and body weight regulation, is an adipokine secreted in a sex-specific manner. Although it has clearly been established that females secrete three to four times more leptin than males and that this sexual dimorphism in leptin secretion is exacerbated with overweight and obesity, the origin and the physiological consequences of this sexual dimorphism remain ill-defined. The adipose tissue is the major site of leptin secretion; however, leptin receptors are ubiquitously expressed, conferring to leptin, and indirectly to the adipose tissue, a potential role in the control of numerous physiological functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29222878/non-communicable-diseases-food-and-nutrition-in-vietnam-from-1975-to-2015-the-burden-and-national-response
#16
Tuan T Nguyen, Minh V Hoang
BACKGROUND AND OBJECTIVES: This review manuscript examines the burden and national response to non-communicable diseases (NCDs), food and nutrition security in Vietnam from 1975 to 2015. METHODS AND STUDY DESIGN: We extracted data from peer-reviewed manuscripts and reports of nationally representative surveys and related policies in Vietnam. RESULTS: In 2010, NCDs accounted for 318,000 deaths (72% of total deaths), 6.7 million years of life lost, and 14 million disability-adjusted life years in Vietnam...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#17
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29221682/effects-of-fructose-consumption-on-food-intake-and-biochemical-and-body-parameters-in-wistar-rats
#18
Viviane Wagner Ramos, Leandro Oliveira Batista, Kelse Tibau Albuquerque
INTRODUTION AND OBJECTIVE: Increased fructose consumption is associated with various metabolic changes that favor the onset of obesity and related comorbidities. The objective of this study was to assess the effects of chronic fructose consumption on body weight and adipose tissue, as well as on serum glucose and triglyceride levels. METHODS: Thirty-day-old Wistar rats were divided into two groups: fructose (F) and control (C), which had free access to commercial chow and either water or a 20% fructose solution...
December 5, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29220798/aegeline-inspired-synthesis-of-novel-amino-alcohol-and-thiazolidinedione-hybrids-with-antiadipogenic-activity-in-3t3-l1-cells
#19
Sabbu Satish, Ankita Srivastava, Pragya Yadav, Salil Varshney, Rakhi Choudhary, Vishal M Balaramnavar, Tadigoppula Narender, Anil Nilkanth Gaikwad
Excess adiposity is a hallmark of obesity, which is caused due to an imbalance between energy intake and energy consumed. Obesity is often associated with several metabolic disorders like dyslipidemia, cardiovascular diseases and type 2 diabetes. Earlier, our group had reported natural product Aegeline (amino-alcohol) isolated from the plant Aegle marmelos as an anti-diabetic and anti-dyslipidemic compound. With this background, we synthesized a series of novel amino alcohol and thiazolidinedione hybrid molecules and studied their antiadipogenic activity...
November 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220719/house-dust-mite-allergen-causes-certain-features-of-steroid-resistant-asthma-in-high-fat-fed-obese-mice
#20
Vijay Pal Singh, Ulaganathan Mabalirajan, Kunal Pratap, Devika Bahal, Deepanshu Maheswari, Atish Gheware, Aabha Bajaj, Lipsa Panda, Ashish Jaiswal, Arjun Ram, Anurag Agrawal
Obesity is a high risk factor for diseases such as cardiovascular, metabolic syndrome and asthma. Obese-asthma is another emerging phenotype in asthma which is typically refractive to steroid treatment due to its non-classical features such as non-eosinophilic cellular inflammation. The overall increased morbidity, mortality and economical burden in asthma is mainly due to steroid resistant asthma. In the present study, we used high fat diet induced obese mice which when sensitized with house dust mite (HDM) showed steroid resistant features...
December 4, 2017: International Immunopharmacology
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