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https://www.readbyqxmd.com/read/29906227/blood-pressure-predicts-endothelial-function-and-the-effects-of-ethinyl-estradiol-exposure-in-young-women
#1
Tessa E Adler, Charlotte W Usselman, Akira Takamata, Nina S Stachenfeld
Hypertension, obesity, and endothelial function predict cardiovascular disease in women and these factors are interrelated. We hypothesized that hypertension and obesity are associated with endothelial dysfunction in young women, and that short-term ethinyl estradiol exposure mitigates this dysfunction. We examined flow-mediated dilation responses before and during 7 days of oral ethinyl estradiol (30 µg/day) in 19 women (25 {plus minus} 5, 18-35 yrs). We divided our sample into two groups based on two criteria: blood pressure and obesity...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905489/assisted-reproductive-technology-comorbidities-and-cardiovascular-risk-the-experience-of-an-italian-center
#2
Cinzia Fatini, Michela Cirillo, Maria Elisabetta Coccia
BACKGROUND: A growing number of infertile women undergo assisted reproductive technology (ART). Older maternal age and the presence of comorbidities may affect cardiovascular (CV) women health. Safety aspects are central in risk assessment; we report the experience of internal medicine clinical setting at the ART center. MATERIALS AND METHODS: we investigated 243 infertile women (110 autologous and 133 oocyte donation [OD]); cardiometabolic parameters and CV risk factors were investigated during the clinical evaluation...
June 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29903789/prevalence-and-clustering-of-cardiovascular-risk-factors-a-cross-sectional-survey-among-nanjing-adults-in-china
#3
Xin Hong, Qing Ye, Jing He, Zhiyong Wang, Huafeng Yang, Shengxiang Qi, Xupeng Chen, Chenchen Wang, Hairong Zhou, Chao Li, Zhenzhen Qin, Fei Xu
OBJECTIVES: To estimate prevalence and clustering of cardiovascular risk factors (CRFs), and investigate the association between relevant characteristics and CRF clustering among adults in eastern China. DESIGN: Community-based cross-sectional study. SETTING: Data were collected by interview survey, physical measurements and laboratory examinations from the 2011 Nanjing Chronic Disease and Risk Factor Surveillance. PARTICIPANTS: A representative sample of 41 072 residents aged ≥18 years volunteered to participate in the survey, with a response rate of 91...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29903689/interplay-between-epicardial-adipose-tissue-metabolic-and-cardiovascular-diseases
#4
Olga Bornachea, Angela Vea, Vicenta Llorente-Cortes
Cardiovascular disease is the primary cause of death in obese and diabetic patients. In these groups of patients, the alterations of epicardial adipose tissue (EAT) contribute to both vascular and myocardial dysfunction. Therefore, it is of clinical interest to determine the mechanisms by which EAT influences cardiovascular disease. Two key factors contribute to the tight intercommunication among EAT, coronary arteries and myocardium. One is the close anatomical proximity between these tissues. The other is the capacity of EAT to secrete cytokines and other molecules with paracrine and vasocrine effects on the cardiovascular system...
June 11, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29902198/intimal-and-medial-arterial-changes-defined-by-ultra-high-frequency-ultrasound-response-to-changing-risk-factors-in-children-with-chronic-kidney-disease
#5
Frida Dangardt, Marietta Charakida, Scott Chiesa, Devina Bhowruth, Alicja Rapala, Daniela Thurn, Franz Schaefer, John Deanfield, Rukshana Shroff
BACKGROUND: Patients with chronic kidney disease (CKD) are exposed to both traditional 'Framingham' and uremia related cardiovascular risk factors that drive atherosclerotic and arteriosclerotic disease, but these cannot be differentiated using conventional ultrasound. We used ultra-high-frequency ultrasound (UHFUS) to differentiate medial thickness (MT) from intimal thickness (IT) in CKD patients, identify their determinants and monitor their progression. METHODS: Fifty-four children and adolescents with CKD and 12 healthy controls underwent UHFUS measurements using 55-70MHz transducers in common carotid and dorsal pedal arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#6
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29901625/high-density-lipoprotein-cholesterol-functionality-and-metabolic-syndrome-protocol-for-review-and-meta-analysis
#7
Leonardo Roever, Elmiro Santos Resende, Angélica Lemos Debs Diniz, Nilson Penha-Silva, João Lucas O'Connell, Paulo Fernando Silva Gomes, Hugo Ribeiro Zanetti, Anaisa Silva Roerver-Borges, Fernando César Veloso, Fernanda Rodrigues de Souza, Poliana Rodrigues Alves Duarte, Thiago Montes Fidale, Antonio Casella-Filho, Paulo Magno Martins Dourado, Antonio Carlos Palandri Chagas, Sadeq Ali-Hasan-Al-Saegh, Paulo Eduardo Ocke Reis, Rogério de Melo Costa Pinto, Gustavo B F Oliveira, Álvaro Avezum, Mansueto Neto, André Rodrigues Durães, Rose Mary Ferreira Lisboa da Silva, Antonio José Grande, Celise Denardi, Renato Delascio Lopes, Nitesh Nerlekar, Shahab Alizadeh, Adrian V Hernandez, Maria Inês da Rosa, Giuseppe Biondi-Zoccai
INTRODUCTION: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia and an increased risk of cardiovascular events. One function of high-density lipoprotein (HDL) cholesterol (HDL-C) is the cholesterol-efflux pathway, which is the pathway where cholesterol is removed from macrophages within the arterial walls back into the bloodstream and out to the liver...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900084/the-psycho-cardiac-coupling-myocardial-remodeling-and-neuroendocrine-factor-levels-the-psychosomatics-of-major-depressive-disorder
#8
REVIEW
Javeria N Syeda, Ian H Rutkofsky, Adnan S Muhammad, Tarig H Balla Abdalla, Zahid Saghir
The association of major depressive disorder (MDD) with myocardial infarction (MI) and vice versa is not unknown. Depression, along with many other systemic factors like atherosclerosis, obesity, diabetes and vascular dysfunction, contributes to the development of adverse cardiac events in the future and, has always been a topic of interest in the fields of cardiology and psychosomatics. We wrote this review article to elaborate this relationship in detail. This article suggests that the individuals with type D personality who already had cardiovascular disease had undergone more serious myocardial damage...
April 11, 2018: Curēus
https://www.readbyqxmd.com/read/29899496/transcriptional-control-of-intestinal-cholesterol-absorption-adipose-energy-expenditure-and-lipid-handling-by-sortilin
#9
Sumihiko Hagita, Maximillian A Rogers, Tan Pham, Jennifer R Wen, Andrew K Mlynarchik, Masanori Aikawa, Elena Aikawa
The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and metabolism contribute to several major human diseases including atherosclerosis and obesity. Sortilin associates with cardiovascular disease; however, the role of Sortilin in adipose tissue and lipid metabolism remains unclear. Here we show that in the low-density lipoprotein receptor-deficient (Ldlr-/- ) atherosclerosis model, Sortilin deficiency (Sort1-/- ) in female mice suppresses Niemann-Pick type C1-Like 1 (Npc1l1) mRNA levels, reduces body and white adipose tissue weight, and improves brown adipose tissue function partially via transcriptional downregulation of Krüppel-like factor 4 and Liver X receptor...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29899044/human-genetics-of-obesity-and-type-2-diabetes-mellitus-past-present-and-future
#10
REVIEW
Erik Ingelsson, Mark I McCarthy
Type 2 diabetes mellitus (T2D) and obesity already represent 2 of the most prominent risk factors for cardiovascular disease, and are destined to increase in importance given the global changes in lifestyle. Ten years have passed since the first round of genome-wide association studies for T2D and obesity. During this decade, we have witnessed remarkable developments in human genetics. We have graduated from the despair of candidate gene-based studies that generated few consistently replicated genotype-phenotype associations, to the excitement of an exponential harvest of loci robustly associated with medical outcomes through ever larger genome-wide association study meta-analyses...
June 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29898822/is-increased-uric-acid-a-risk-factor-or-a-defensive-response-the-campania-salute-network
#11
C Mancusi, R Izzo, L A Ferrara, F Rozza, M A Losi, G Canciello, M Pepe, N de Luca, B Trimarco, G de Simone
BACKGROUND AND AIMS: Circulating uric acid (UA) is positively associated with body mass index (BMI), blood glucose, blood pressure (BP), markers of inflammation, and altered lipid profile. UA has also anti-oxidative properties which might be beneficial for cardiovascular (CV) system. It is still debated whether or not UA is independently associated with increased CV morbidity and/or mortality. METHODS AND RESULTS: We studied prognostic impact of UA in 8833 hypertensive adults (mean age 53 ± 12 yrs, 3857 women) from the Campania Salute Network, without prevalent CV disease and more than stage 3 CKD...
May 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29898625/branched-chain-amino-acids-are-associated-with-metabolic-parameters-in-bipolar-disorder
#12
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29897431/perceived-cardiovascular-risk-and-attitude-towards-lifestyle-change
#13
Krisztián Vörös, Bernadett Márkus, Csenge Hargittay, Orsolya Sisak, László Kalabay
Background: Cardiovascular diseases are prominent cause of death. Lifestyle change is effective in decreasing mortality. Perception of patients' cardiovascular risk by physicians is a drive for following preventive recommendations. Whether the hazard perceived by patients influences their attitude towards lifestyle is uncertain. Objective: We hypothesized that high perceived risk would be associated with a stronger determination for lifestyle change, while incorrectly optimistic patients would be less motivated...
April 20, 2018: Family Practice
https://www.readbyqxmd.com/read/29896844/effects-of-6-months-supervised-physical-training-on-muscle-strength-and-aerobic-capacity-in-patients-undergoing-roux-en-y-gastric-bypass-surgery-a-randomized-controlled-trial
#14
L H Mundbjerg, C R Stolberg, E-M Bladbjerg, P Funch-Jensen, C B Juhl, B Gram
Obesity and physical inactivity are major health problems. Roux-en-Y gastric bypass (RYGB) surgery results in significant weight loss and reduces obesity-related morbidity and mortality. Physical activity lowers the risk of cardiovascular disease and premature death. The aims of this study were to elucidate the effects of RYGB followed by 6 months of supervised physical training on physical capacity. In a randomized controlled trial, 60 participants eligible for RYGB were randomized 6 months post-surgery to either two weekly physical training sessions for 26 weeks (INT) or a control group (CON)...
June 12, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29895516/physical-wellness-among-gaming-adults-cross-sectional-study
#15
James Arnaez, Georgia Frey, Donetta Cothran, Margaret Lion, Andrea Chomistek
BACKGROUND: Video and hobby gaming are immensely popular among adults; however, associations between gaming and health have primarily been investigated in children and adolescents. Furthermore, most research has focused on electronic gaming, despite traditional hobby gaming gaining prominence. OBJECTIVE: To determine whether the number of platforms used, platform preference, and gaming time are associated with obesity, physical activity, sedentary behavior, and cardiovascular risk factors in an adult gaming population...
June 12, 2018: JMIR Serious Games
https://www.readbyqxmd.com/read/29895033/metabolic-syndrome-in-hypopituitarism
#16
Dragana Miljić, Vera Popovic
Prevalence of metabolic syndrome (MetS) and mortality rates from cardiovascular causes are increased in patients with hypopituitarism. Features of obesity, visceral adiposity, dyslipidemia, insulin resistance, and hypertension are common in these patients. Unreplaced growth hormone (GH) deficiency and inadequate replacement of other hormone insufficiencies may be responsible for the adverse body composition and metabolic profile associated with hypopituitarism. Recently, fatty liver disease was added to this unfavorable metabolic phenotype...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29895021/metabolic-syndrome-in-parathyroid-diseases
#17
Sabrina Corbetta, G Mantovani, A Spada
Parathyroid glands are the main regulator of body mineral metabolism through parathormone (PTH) actions on bone and kidney. Experimental evidence suggests that PTH may have non-classical target organs such as adipose tissue, arterial vascular wall, cardiac muscle cells, and adrenal cortex cells, where it may play a role in controlling body energy, blood pressure, and metabolism. Cardiometabolic features have been investigated in the wide spectrum of clinical parathyroid disorders, from hyperparathyroidism to pseudohypoparathyroidism and hypoparathyroidism...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29895006/the-metabolic-syndrome-in-central-hypogonadotrophic-hypogonadism
#18
Andrew A Dwyer, Richard Quinton
The metabolic syndrome (MetS) is a term used to describe the constellation of cardiometabolic risk factors including central adiposity, dyslipidemia, insulin resistance, non-alcoholic fatty liver disease and arterial hypertension. Notably, a number of studies have shown high rates of testosterone (T) deficiency in men with MetS and type 2 diabetes mellitus (T2DM). Both hypogonadism and MetS confer increased health risk for morbidity and mortality as men with the MetS are at twice the risk for developing cardiovascular disease and at 5-fold higher risk for developing T2DM...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29894990/metabolic-syndrome-in-polycystic-ovary-syndrome
#19
Renato Pasquali
Both prevalence and incidence of the metabolic syndrome is very high in women with polycystic ovary syndrome (PCOS). Obesity and visceral fat enlargement play a dominant role in determining the final phenotype of PCOS. Androgen excess and insulin resistance may be responsible for the development of all features of the metabolic syndrome. The major factors responsible for this association seem to be related to a triumvirate including androgen excess, insulin resistance and associated hyperinsulinemia, and obesity, particularly the abdominal-visceral phenotype...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29894989/metabolic-syndrome-in-cushing-s-syndrome-patients
#20
Francesco Ferraù, Márta Korbonits
Cushing's syndrome (CS), including visceral obesity, dyslipidemia, hypertension and diabetes among its many manifestations, is "a model" of metabolic syndrome. Glucocorticoid (GC) excess, through a combination of effects on liver, muscle, adipose tissue and pancreas, increases gluconeogenesis and impairs insulin sensitivity, leading to carbohydrate abnormalities. Dyslipidemia is a common finding in CS as a consequence of GC-related increased lipolysis, lipogenesis and adipogenesis. CS patients experience typical changes in body composition, with fat redistribution resulting in accumulation of visceral adipose tissue...
2018: Frontiers of Hormone Research
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