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https://www.readbyqxmd.com/read/28716432/effect-of-frequency-and-focal-spacing-on-transcranial-histotripsy-clot-liquefaction-using-electronic-focal-steering
#1
Tyler Gerhardson, Jonathan R Sukovich, Aditya S Pandey, Timothy L Hall, Charles A Cain, Zhen Xu
This in vitro study investigated the effects of ultrasound frequency and focal spacing on blood clot liquefaction via transcranial histotripsy. Histotripsy pulses were delivered using two 256-element hemispherical transducers of different frequency (250 and 500 kHz) with 30-cm aperture diameters. A 4-cm diameter spherical volume of in vitro blood clot was treated through 3 excised human skullcaps by electronically steering the focus with frequency proportional focal spacing: λ/2, 2 λ/3 and λ with 50 pulses per location...
July 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28658334/customized-acrylic-implants-for-reconstruction-of-extensive-skull-defects-an-exception-approach-for-selected-patients
#2
Rafael Denadai Pigozzi DA Silva, Cesar Augusto Raposo-Amaral, Marcelo Campos Guidi, Cassio Eduardo Raposo-Amaral, Celso Luiz Buzzo
Objective: to present our experience in the surgical treatment of extensive skullcap defects with customized acrylic implants. Methods: we conducted a retrospective analysis of patients with extensive skull defects undergoing acrylic cranioplasties between 2004 and 2013. We carefully selected all patients and classified surgical results based on three scales (craniofacial esthetics, improvement of facial symmetry and need for additional surgery). Results: fifteen patients underwent cranioplasty with intraoperative acrylic implants, whether manually customized (46...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28573603/influence-of-culture-medium-composition-and-light-conditions-on-the-accumulation-of-bioactive-compounds-in-shoot-cultures-of-scutellaria-lateriflora-l-american-skullcap-grown-in-vitro
#3
Beata Kawka, Inga Kwiecień, Halina Ekiert
Methanolic extracts from in vitro grown Scutellaria lateriflora shoots cultured on five Murashige and Skoog (MS) medium variants supplemented with different combinations of 6-benzylaminopurine (BAP) and α-naphthaleneacetic acid (NAA) under different light conditions (monochromatic light, white light and no light) were analysed by HPLC for three groups of metabolites: flavonoids (26 compounds), phenolic acids and their precursors (19+2) and phenylethanoid glycosides (2). The analyses revealed the presence of baicalein, baicalin, wogonin, wogonoside, 3,4-dihydroxyphenylacetic acid and verbascoside...
June 1, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28284428/distribution-patterns-of-the-contents-of-five-biologically-activate-ingredients-in-the-root-of-scutellaria-baicalensis
#4
Rong-Xiu Liu, Guo-Hu Song, Pei-Gen Wu, Xue-Wen Zhang, Hui-Juan Hu, Jia Liu, Xiao-Su Miao, Zhi-Yan Hou, Wen-Quan Wang, Sheng-Li Wei
As an important herbaceous plant, Scutellaria baicalensis Georgi (Chinese skullcap) is geographically widespread and commonly used throughout the world. In the Chinese medicine market, S. baicalensis has been divided into two primary types, "Ku Qin" (WXR) and "Tiao Qin" (TST). Moreover, TST is also divided into different grades according to the diameter of roots. To explore the distribution patterns of the contents of five biologically activate ingredients (FBAI), we used six-year-old cultivated S. baicalensis and analyzed its growth characteristics as well as the quality difference among different types and diameters in roots...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28274529/japanese-herbal-medicine-induced-pneumonitis-a-review-of-73-patients
#5
Yasunori Enomoto Md, Yutaro Nakamura Md PhD, Noriyuki Enomoto Md PhD, Tomoyuki Fujisawa Md PhD, Naoki Inui Md PhD, Takafumi Suda
BACKGROUND: The number of reports concerning Japanese herbal medicine (JHM)-induced pneumonitis has increased. However, comprehensive data are lacking in this regard, and the clinical characteristics of the disease remain unclear. METHODS: A literature review was performed using PubMed and Ichushi-Web-the database of the Japan Medical Abstracts Society-to identify articles published between 1996 and 2015 describing patients with JHM-induced pneumonitis. The final cohort included 73 patients in 59 articles (7 in English; 52 in Japanese)...
March 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28259249/anti-tumor-activity-of-wogonin-an-extract-from-scutellaria-baicalensis-through-regulating-different-signaling-pathways
#6
REVIEW
Do Luong Huynh, Neelesh Sharma, Amit Kumar Singh, Simrinder Singh Sodhi, Jiao-Jiao Zhang, Raj Kumar Mongre, Mrinmoy Ghosh, Nameun Kim, Yang Ho Park, Dong Kee Jeong
Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt (also known as protein kinase B) and AMP-activated protein kinase (AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity...
January 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27814566/baicalin-a-natural-lsd1-inhibitor
#7
Yi-Chao Zheng, Dan-Dan Shen, Meng Ren, Xue-Qi Liu, Zhi-Ru Wang, Ying Liu, Qian-Na Zhang, Li-Juan Zhao, Li-Jie Zhao, Jin-Lian Ma, Bin Yu, Hong-Min Liu
Baicalin is one of the active ingredients in the skullcap, with a variety of pharmacological effects, such as blood pressure reduction, sedation, liver-protection, gallbladder-protection, anti-bacteria, and anti-inflammation. In our study, baicalin was first characterized as a LSD1 inhibitor with an IC50 of 3.01μM and showed strong LSD1 inhibitory effect in cells. Baicalin may serve as a template for designing flavone-based LSD1 inhibitors.
December 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27790646/the-extraction-anticancer-effect-bioavailability-and-nanotechnology-of-baicalin
#8
Ondrea A Moore, Ying Gao, Allen Y Chen, Ross Brittain, Yi Charlie Chen
The dried root of Baikal skullcap (Scutellaria baicalensis) has been historically and widely used in traditional Eastern medicine. Modern science proved that baicalin is the major bioactive responsible for the physiological activity of Baikal skullcap. Baicalin, a flavonoid found in several species in the genus Scutellaria, has been regarded as a potent anticancer agent. In this review, we present the main extraction methods, anticancer activity and bioavailability of baicalin. Besides, the utilization of nanotechnology to improve the bioavailability of baicalin is also mentioned...
2016: Journal of Nutritional Medicine and Diet Care
https://www.readbyqxmd.com/read/27730005/scutellaria-baicalensis-the-golden-herb-from-the-garden-of-chinese-medicinal-plants
#9
Qing Zhao, Xiao-Ya Chen, Cathie Martin
Scutellaria baicalensis Georgi, or Chinese skullcap, has been widely used as a medicinal plant in China for thousands of years, where the preparation from its roots is called Huang-Qin. It has been applied in the treatment of diarrhea, dysentery, hypertension, hemorrhaging, insomnia, inflammation and respiratory infections. Flavones such as baicalin, wogonoside and their aglycones baicalein wogonin are the major bioactive compounds extracted from the root of S. baicalensis. These flavones have been reported to have various pharmacological functions, including anti-cancer, hepatoprotection, antibacterial and antiviral, antioxidant, anticonvulsant and neuroprotective effects...
2016: Science Bulletin
https://www.readbyqxmd.com/read/27537870/rapid-isolation-and-determination-of-flavones-in-biological-samples-using-zinc-complexation-coupled-with-high-performance-liquid-chromatography
#10
Chenghe Sun, Hecheng Wang, Yingping Wang, Shengyuan Xiao
Chlorophyll-type contaminants are commonly encountered in the isolation and determination of flavones of plant aerial plant parts. Heme is also a difficult background substance in whole blood analysis. Both chlorophyll and heme are porphyrin type compounds. In this study, a rapid method for isolating flavones with 5-hydroxyl or ortho-hydroxyl groups from biological samples was developed based on the different solubilities of porphyrin-metal and flavone-metal complexes. It is important that other background substances, e...
August 16, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27323609/-analysis-of-medication-laws-for-chinese-medicine-treating-hypertension-patients-with-yin-defi-ciency-yang-hyperactivity-syndrome-based-on-literatures
#11
REVIEW
Ning Ma, Ya-zhu Hou, Xian-liang Wang, Jing-yuan Mao
OBJECTIVE: To analyze medication laws of Chinese medicine (CM) treatment in hypertension patients with yin deficiency yang hyperactivity syndrome. METHODS: China National Knowledge Infrastructure (CNKI, Jan. 1979-Dec 2014), Chinese Scientific Journals Database (VIP, Jan 1989-Dec2014), Chinese Biomedical Literature Database (CBM, Jan.1978-Dec.2014), Wanfang Database (Jan 1990-Dec 2014) were retrieved by using "hypertension", "CM", "Chinese herbs", "syndrome" as keywords...
April 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/27314314/inhibition-of-advanced-glycation-end-product-formation-and-antioxidant-activity-by-extracts-and-polyphenols-from-scutellaria-alpina-l-and-s-altissima-l
#12
Izabela Grzegorczyk-Karolak, Krzysztof Gołąb, Jakub Gburek, Halina Wysokińska, Adam Matkowski
Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90...
June 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27144042/acute-hepatitis-after-ingestion-of-a-preparation-of-chinese-skullcap-and-black-catechu-for-joint-pain
#13
Charilaos Papafragkakis, Mel A Ona, Madhavi Reddy, Sury Anand
Many herbal preparations are routinely used and have been occasionally associated with a wide range of side effects, from mild to severe. Chinese skullcap and black catechu are herbal medications commonly used for their hepatoprotective and other properties. We report a case of acute toxic hepatitis associated with ingestion of Chinese skullcap and black catechu in one preparation for the alleviation of joint pain.
2016: Case Reports in Hepatology
https://www.readbyqxmd.com/read/27143122/modulation-of-the-nrf2-signalling-pathway-in-hct116-colon-carcinoma-cells-by-baicalein-and-its-methylated-derivative-negletein
#14
COMPARATIVE STUDY
Susannah Havermann, Yvonni Chovolou, Hans-Ulrich Humpf, Wim Wätjen
CONTEXT: Baicalein is a major compound in extracts derived from Scutellaria baicalensis Georgi (Lamiaceae) which are used in the Traditional Chinese Medicine for the treatment of inflammatory and gastrointestinal diseases. This flavonoid is an activator of the Nrf2 signalling pathway but the molecular mechanism is not clearly established. OBJECTIVE: We investigated the molecular mode of baicalein-mediated Nrf2-activation in Hct116 cells by the analysis of proteasomal activity, radical-scavenging activity and the comparison with baicalein derivatives...
September 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27022718/simultaneous-determination-of-baicalein-and-baicalin-in-human-plasma-by-high-performance-liquid-chromatograph-tandem-spectrometry-and-its-application-in-a-food-effect-pharmacokinetic-study
#15
H Pang, A Shi, M Li, W Xue, Y Li, G Cao, B Yan, F Dong, W Xiao, G He, G Du, X Hu, G Cheng
BACKGROUND: Baicalein is a flavonoid isolated from skullcap and it is likely to exist in plasma at a low concentration because of the extensive first-pass metabolism in vivo. The aim of our study was to develop and fully validate a sensitive and selective HPLC-MS/MS method for simultaneous determination of baicalein and its main metabolite baicalin (baicalein-7-O-β-glucopyranuronoside) in human plasma. MATERIALS AND METHODS: Liquid-liquid extraction was used for pretreatment of plasma samples...
August 2016: Drug Research
https://www.readbyqxmd.com/read/26927474/the-screening-and-evaluation-of-herbs-and-identification-of-herbal-combinations-with-anti-viral-effects-on-newcastle-disease-virus
#16
M Wang, Y Yu, K Brad, W Xie, X-Y Zhang
A total of 25 "heat-clearing and detoxifying" herbs used in Chinese medicine were investigated for their cytopathic effects on the growth of Newcastle Disease virus (NDV) in a chicken fibroblast cell line. The 5 herbs with the highest virus inhibitory effects were Herba agastaches, Flos chrysanthemi indici, Rhizoma anemarrhenae, Astragalus root and Baikal skullcap root and these were used in herbal formulations. Anti-NDV activities of 4 formulations were tested on the growth of NDV in the DF-1 fibroblast cell line...
2016: British Poultry Science
https://www.readbyqxmd.com/read/26890732/targeted-lesion-generation-through-the-skull-without-aberration-correction-using-histotripsy
#17
Jonathan Sukovich, Zhen Xu, Yohan Kim, Hui Cao, Thai-Son Nguyen, Aditya Pandey, Timothy Hall, Charles Cain
This study demonstrates the ability of histotripsy to generate targeted lesions through the skullcap without using aberration correction. Histotripsy therapy was delivered using a 500 kHz, 256-element hemispherical transducer with an aperture diameter of 30 cm and a focal distance of 15 cm fabricated in our lab. This transducer is theoretically capable of producing peak rarefactional pressures, based on linear estimation, (p-)LE, in the free field in excess of 200MPa with pulse durations 2 acoustic cycles. Three excised human skullcaps were used displaying attenuations of 73-81% of the acoustic pressure without aberration correction...
February 18, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/26605827/comparison-of-analytical-and-numerical-approaches-for-ct-based-aberration-correction-in-transcranial-passive-acoustic-imaging
#18
COMPARATIVE STUDY
Ryan M Jones, Kullervo Hynynen
Computed tomography (CT)-based aberration corrections are employed in transcranial ultrasound both for therapy and imaging. In this study, analytical and numerical approaches for calculating aberration corrections based on CT data were compared, with a particular focus on their application to transcranial passive imaging. Two models were investigated: a three-dimensional full-wave numerical model (Connor and Hynynen 2004 IEEE Trans. Biomed. Eng. 51 1693-706) based on the Westervelt equation, and an analytical method (Clement and Hynynen 2002 Ultrasound Med...
January 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26598817/food-and-natural-materials-target-mechanisms-to-effectively-regulate-allergic-responses
#19
Hee Soon Shin, Dong-Hwa Shon
An immune hypersensitivity disorder called allergy is caused by diverse allergens entering the body via skin contact, injection, ingestion, and/or inhalation. These allergic responses may develop into allergic disorders, including inflammations such as atopic dermatitis, asthma, anaphylaxis, food allergies, and allergic rhinitis. Several drugs have been developed to treat these allergic disorders; however, long-term intake of these drugs could have adverse effects. As an alternative to these medicines, food and natural materials that ameliorate allergic disorder symptoms without producing any side effects can be consumed...
2015: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/26481113/a-new-iron-calcium-phosphate-material-to-improve-the-osteoconductive-properties-of-a-biodegradable-ceramic-a-study-in-rabbit-calvaria
#20
Angel Manchón, Mohammad Hamdan Alkhraisat, Carmen Rueda-Rodriguez, Juan Carlos Prados-Frutos, Jesús Torres, Julia Lucas-Aparicio, Andrea Ewald, Uwe Gbureck, Enrique López-Cabarcos
β-tricalcium phosphate (β-TCP) is an osteoconductive and biodegradable material used in bone regeneration procedures, while iron has been suggested as a tool to improve the biological performance of calcium phosphate-based materials. However, the mechanisms of interaction between these materials and human cells are not fully understood. In order to clarify this relationship, we have studied the iron role in β-TCP ceramics. Iron-containing β-TCPs were prepared by replacing CaCO3 with C6H5FeO7 at different molar ratios...
September 2015: Biomedical Materials
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