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https://www.readbyqxmd.com/read/29049291/a-deep-convolutional-neural-network-for-classification-of-red-blood-cells-in-sickle-cell-anemia
#1
Mengjia Xu, Dimitrios P Papageorgiou, Sabia Z Abidi, Ming Dao, Hong Zhao, George Em Karniadakis
Sickle cell disease (SCD) is a hematological disorder leading to blood vessel occlusion accompanied by painful episodes and even death. Red blood cells (RBCs) of SCD patients have diverse shapes that reveal important biomechanical and bio-rheological characteristics, e.g. their density, fragility, adhesive properties, etc. Hence, having an objective and effective way of RBC shape quantification and classification will lead to better insights and eventual better prognosis of the disease. To this end, we have developed an automated, high-throughput, ex-vivo RBC shape classification framework that consists of three stages...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29049283/the-impact-of-muscle-relaxation-techniques-on-the-quality-of-life-of-cancer-patients-as-measured-by-the-fact-g-questionnaire
#2
Paula Parás-Bravo, Paloma Salvadores-Fuentes, Cristina Alonso-Blanco, María Paz-Zulueta, Miguel Santibañez-Margüello, Domingo Palacios-Ceña, Ester Boixadera-Planas, César Fernández-de-Las-Peñas
INTRODUCTION: Patients with cancer frequently suffer from emotional distress, characterized by psychological symptoms such as anxiety or depression. The presence of psychological symptoms combined with the complex nature of oncology processes can negatively impact patients' quality of life. We aimed to determine the impact of a relaxation protocol on improving quality of life in a sample of oncological patients treated in the Spanish National Public Health System. MATERIALS AND METHODS: We conducted a multicenter interventional study without a control group...
2017: PloS One
https://www.readbyqxmd.com/read/29048214/validation-of-a-full-immersion-simulation-platform-for-percutaneous-nephrolithotomy-using-3d-printing-technology
#3
Ahmed Ghazi, Timothy Campbell, Rachel Melnyk, Changyong Feng, Alex Andrusco, Jonathan Stone, Erdal Erturk
INTRODUCTION AND OBJECTIVES: The restriction of resident hours with an increasing focus on patient safety and a reduced caseload has impacted surgical training. A complex and complication prone procedure such as percutaneous nephrolithotomy (PCNL) with a steep learning curve may create an unsafe environment for hands-on resident training. In this study, we validate a high fidelity, inanimate PCNL model within a full immersion simulation environment. METHODS: Anatomically correct models of the human pelvicalyceal system (PCS), kidney, and relevant adjacent structures were created using poly-vinyl alcohol (PVA) hydrogels and 3D-printed injection molds...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29048185/impulsivity-and-approach-tendencies-towards-cigarette-stimuli-implications-for-cigarette-smoking-and-cessation-behaviors-among-youth
#4
Hanna Weckler, Grace Kong, Helle Larsen, Janna Cousijn, Reinout W Wiers, Suchitra Krishnan-Sarin
Impulsivity is associated with smoking, difficulties quitting smoking, and approach tendencies toward cigarette stimuli among adolescents. We examined the effects of impulsivity on (a) the association between approach tendencies and adolescents' smoking status and (b) the effectiveness of Cognitive Bias Modification (CBM), a smoking cessation intervention focused on changing approach tendencies, among adolescent smokers. We conducted a secondary analysis of evidence from 2 previous published studies: Study 1: a cross-sectional study comparing impulsivity and approach tendencies between adolescent smokers (n = 67) and nonsmokers (n = 58); Study 2: a treatment study that randomized 60 adolescent smokers to receive either CBM or sham training...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29047393/the-human-behaviour-change-project-harnessing-the-power-of-artificial-intelligence-and-machine-learning-for-evidence-synthesis-and-interpretation
#5
Susan Michie, James Thomas, Marie Johnston, Pol Mac Aonghusa, John Shawe-Taylor, Michael P Kelly, Léa A Deleris, Ailbhe N Finnerty, Marta M Marques, Emma Norris, Alison O'Mara-Eves, Robert West
BACKGROUND: Behaviour change is key to addressing both the challenges facing human health and wellbeing and to promoting the uptake of research findings in health policy and practice. We need to make better use of the vast amount of accumulating evidence from behaviour change intervention (BCI) evaluations and promote the uptake of that evidence into a wide range of contexts. The scale and complexity of the task of synthesising and interpreting this evidence, and increasing evidence timeliness and accessibility, will require increased computer support...
October 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29047339/exploring-the-evidence-base-for-how-people-with-dementia-and-their-informal-carers-manage-their-medication-in-the-community-a-mixed-studies-review
#6
Lydia Aston, Andrea Hilton, Tiago Moutela, Rachel Shaw, Ian Maidment
BACKGROUND: Little is known about the general medicines management issues for people with dementia living in the community. This review has three aims: firstly to explore and evaluate the international literature on how people with dementia manage medication; assess understanding of medicines management from an informal carers perspective; and lastly to understand the role that healthcare professionals play in assisting this population with medicines management. METHODS: A mixed studies review was conducted...
October 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29047336/a-qualitative-exploration-of-work-related-head-injury-vulnerability-at-the-intersection-of-workers-decision-making-and-organizational-values
#7
P Kontos, A Grigorovich, B Nowrouzi, B Sharma, J Lewko, T Mollayeva, A Colantonio
BACKGROUND: Work-related head injury is a critical public health issue due to its rising prevalence; the association with profound disruption of workers' lives; and significant economic burdens in terms of medical costs and lost wages. Efforts to understand and prevent these types of injuries have largely been dominated by epidemiological research and safety science, which has focused on identifying risk at the level of the individual worker, population group, or organizational sector...
October 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29046634/cognitive-training-enhances-auditory-attention-efficiency-in-older-adults
#8
Jennifer L O'Brien, Jennifer J Lister, Bernadette A Fausto, Gregory K Clifton, Jerri D Edwards
Auditory cognitive training (ACT) improves attention in older adults; however, the underlying neurophysiological mechanisms are still unknown. The present study examined the effects of ACT on the P3b event-related potential reflecting attention allocation (amplitude) and speed of processing (latency) during stimulus categorization and the P1-N1-P2 complex reflecting perceptual processing (amplitude and latency). Participants completed an auditory oddball task before and after 10 weeks of ACT (n = 9) or a no contact control period (n = 15)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29045504/molecular-tumor-boards-current-practice-and-future-needs
#9
D L van der Velden, C M L van Herpen, H W M van Laarhoven, E F Smit, H J M Groen, S M Willems, P M Nederlof, M H G Langenberg, E Cuppen, S Sleijfer, N Steeghs, E E Voest
Background: due to rapid technical advances, steeply declining sequencing costs, and the ever-increasing number of targeted therapies, it can be expected that extensive tumor sequencing such as Whole Exome- and -Genome Sequencing will soon be applied in standard care. Clinicians will thus be confronted with increasingly complex genetic information and multiple test-platforms to choose from. General medical training, meanwhile, can hardly keep up with the pace of innovation. Consequently, there is a rapidly growing gap between clinical knowledge and genetic potential in cancer care...
September 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044780/-hot-versus-cold-behavioral-cognitive-styles-motivational-dopaminergic-versus-cognitive-cholinergic-processing-of-a-pavlovian-cocaine-cue-in-sign-and-goal-tracking-rats
#10
Kyle K Pitchers, Louisa F Kane, Youngsoo Kim, Terry E Robinson, Martin Sarter
Discrete Pavlovian reward cues acquire more potent incentive motivational properties (incentive salience), in some animals (sign-trackers; STs) compared to others (goal trackers; GTs). Conversely, GTs appear to be better than STs in processing more complex contextual cues, perhaps reflecting their relatively greater bias for goal-directed cue processing. Here we investigated the activity of two major prefrontal neuromodulatory input systems, dopamine (DA) and acetylcholine (ACh), in response to a discrete Pavlovian cue that was previously paired with cocaine administration in STs and GTs...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29044368/use-of-bayesian-networks-in-predicting-contamination-of-drinking-water-with-e-coli-in-rural-vietnam
#11
David C Hall, Quynh B Le
Background: More than 70 million Vietnamese rely on small-scale farming for some form of household income. Water on many of those farms is contaminated with waste, including animal manure, partly due to non-sustainable waste management. This increases the risk of water-related zoonotic disease transmission. The purpose of this research was to examine the impact of various demographic and management factors on the likelihood of finding Escherichia coli in drinking water sourced from wells and rainwater on farms in Vietnam...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29042848/integrated-diabetes-care-delivered-by-patients-a-case-study-from-bulgaria
#12
Verena Struckmann, Francesco Barbabella, Antoniya Dimova, Ewout van Ginneken
INTRODUCTION: Increasing numbers of persons are living with multiple chronic diseases and unmet medical needs in Bulgaria. The Bulgarian 'Diabetic care' non-profit (DCNPO) programme aims to provide comprehensive integrated care focusing on people with diabetes and their co-morbidities. METHODS: The DCNPO programme was selected as one of eight 'high potential' programmes in the Innovating Care for People with Multiple Chronic Conditions (ICARE4EU) project, covering 31 European countries...
March 31, 2017: International Journal of Integrated Care
https://www.readbyqxmd.com/read/29042585/compact-morphology-based-poly-metallic-nodule-delineation
#13
Timm Schoening, Daniel O B Jones, Jens Greinert
Poly-metallic nodules are a marine resource considered for deep sea mining. Assessing nodule abundance is of interest for mining companies and to monitor potential environmental impact. Optical seafloor imaging allows quantifying poly-metallic nodule abundance at spatial scales from centimetres to square kilometres. Towed cameras and diving robots acquire high-resolution imagery that allow detecting individual nodules and measure their sizes. Spatial abundance statistics can be computed from these size measurements, providing e...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29041210/910-m-propagation-of-thz-ps-pulses-through-the-atmosphere
#14
Gyeong-Ryul Kim, Tae-In Jeon, D Grischkowsky
We measured the atmospheric propagation of ps THz pulses with a 0.4-THz bandwidth through a 910-m distance; the pulse delay corresponded to 255 pulses down the pulse train of the mode-locked ring laser excitation pulses. The complexity of the atmosphere requires the use of the complete theory of Essen and Froome to compare the measured time shifts due to both the dry atmosphere and water vapor with theoretical calculations. A new procedure involving the measurement of phase in the frequency domain is introduced and achieves comparable results for the calculated time shifts, compared to the previous direct measurements of time shifts...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29041057/dual-comb-generation-from-a-mode-locked-fiber-laser-with-orthogonally-polarized-interlaced-pulses
#15
Ahmet E Akosman, Michelle Y Sander
Ultra-high precision dual-comb spectroscopy traditionally requires two mode-locked, fully stabilized lasers with complex feedback electronics. We present a novel mode-locked operation regime in a thulium-holmium co-doped fiber laser, a frequency-halved state with orthogonally polarized interlaced pulses, for dual comb generation from a single source. In a linear fiber laser cavity, an ultrafast pulse train composed of co-generated, equal intensity and orthogonally polarized consecutive pulses at half of the fundamental repetition rate is demonstrated based on vector solitons...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29039935/numerical-optimization-of-density-functional-tight-binding-models-application-to-molecules-containing-carbon-hydrogen-nitrogen-and-oxygen
#16
Aditi Krishnapriyan, Ping Yang, Anders M N Niklasson, Marc J Cawkwell
New parameterizations for semi-empirical density functional tight binding (DFTB) theory have been developed by the numerical optimization of adjustable parameters to minimize errors in the atomization energy and interatomic forces with respect to ab initio calculated data. Initial guesses for the radial dependences of the Slater-Koster bond integrals and overlap integrals were obtained from minimum basis density functional theory calculations. The radial dependences of the pair potentials and the bond and overlap integrals were represented by simple analytic functions...
October 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29038859/refashioned-lamb-tissue-as-an-animal-model-for-training-complex-techniques-of-laryngotracheal-stenosis-surgery
#17
Lluís Nisa, Pedro Teiga, Gustavo Barreto da Cunha, Biswanath Roy, Riza Onder Gunaydin, Kishore Sandu
Open reconstructive upper airway surgery for laryngotracheal stenosis (LTS), whether for subglottic or tracheal stenosis, constitutes a group of complex approaches. LTS requiring open reconstruction is overall rare and primarily performed at tertiary centres. This poses an obvious challenge for the acquisition and maintenance of surgical skills for this group of complex approaches. In this context, animal models provide a unique opportunity for open reconstructive airway surgery training. Such models ought to take into consideration ethical aspects, be easily available and easy to maintain, and have similar macroscopic anatomical features to the human laryngotracheal frame...
October 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29037823/the-development-of-a-novel-perfused-cadaver-model-with-dynamic-vital-sign-regulation-and-real-world-scenarios-to-teach-surgical-skills-and-error-management
#18
Michael Minneti, Craig J Baker, Maura E Sullivan
The landscape of graduate medical education has changed dramatically over the past decade and the traditional apprenticeship model has undergone scrutiny and modifications. The mandate of the 80-hour work-week, the introduction of integrated residency programs, increased global awareness about patient safety along with financial constraints have spurred changes in graduate educational practices. In addition, new technologies, more complex procedures, and a host of external constraints have changed where and how we teach technical and procedural skills...
October 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29037173/taxmapper-an-analysis-tool-reference-database-and-workflow-for-metatranscriptome-analysis-of-eukaryotic-microorganisms
#19
Daniela Beisser, Nadine Graupner, Lars Grossmann, Henning Timm, Jens Boenigk, Sven Rahmann
BACKGROUND: High-throughput sequencing (HTS) technologies are increasingly applied to analyse complex microbial ecosystems by mRNA sequencing of whole communities, also known as metatranscriptome sequencing. This approach is at the moment largely limited to prokaryotic communities and communities of few eukaryotic species with sequenced genomes. For eukaryotes the analysis is hindered mainly by a low and fragmented coverage of the reference databases to infer the community composition, but also by lack of automated workflows for the task...
October 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29036404/the-value-of-prior-knowledge-in-machine-learning-of-complex-network-systems
#20
Dana Ferranti, David Krane, David Craft
Motivation: Our overall goal is to develop machine-learning approaches based on genomics and other relevant accessible information for use in predicting how a patient will respond to a given proposed drug or treatment. Given the complexity of this problem, we begin by developing, testing and analyzing learning methods using data from simulated systems, which allows us access to a known ground truth. We examine the benefits of using prior system knowledge and investigate how learning accuracy depends on various system parameters as well as the amount of training data available...
July 7, 2017: Bioinformatics
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