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adherence asthma

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https://www.readbyqxmd.com/read/29162108/reduced-suppressive-effect-of-%C3%AE-2-adrenoceptor-agonist-on-fibrocyte-function-in-severe-asthma
#1
Chun-Yu Lo, Charalambos Michaeloudes, Pankaj K Bhavsar, Chien-Da Huang, Po-Jui Chang, Chun-Hua Wang, Han-Pin Kuo, Kian Fan Chung
BACKGROUND: Patients with severe asthma have increased airway remodelling and elevated numbers of circulating fibrocytes with enhanced myofibroblastic differentiation capacity, despite being treated with high doses of corticosteroids, and long acting β2-adrenergic receptor (AR) agonists (LABAs). We determined the effect of β2-AR agonists, alone or in combination with corticosteroids, on fibrocyte function. METHODS: Non-adherent non-T cells from peripheral blood mononuclear cells isolated from healthy subjects and patients with non-severe or severe asthma were treated with the β2-AR agonist, salmeterol, in the presence or absence of the corticosteroid dexamethasone...
November 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29152167/differences-in-medication-adherence-are-associated-with-beliefs-about-medicines-in-asthma-and-copd
#2
Susanne Brandstetter, Tamara Finger, Wiebke Fischer, Magdalena Brandl, Merle Böhmer, Michael Pfeifer, Christian Apfelbacher
Adherence to medication is crucial for achieving treatment control in chronic obstructive lung diseases. This study refers to the "necessity-concerns framework" and examines the associations between beliefs about medicines and self-reported medication adherence in people with chronic obstructive lung disease. 402 patients (196 with asthma, 206 with COPD) participated in the study and completed a questionnaire comprising the "Beliefs about Medicines-Questionnaire" (BMQ) and the "Medication Adherence Report Scale" (MARS)...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29151559/-effects-of-education-about-action-plans-according-to-self-monitoring-on-self-management-adherence-knowledge-symptom-control-and-quality-of-life-among-adult-asthma-patients-a-randomized-controlled-trial
#3
Ja Yun Choi, Young Ran Kweon
PURPOSE: This study was conducted to identify the effects of education regarding action plans according to a self-monitoring program on self-management adherence, knowledge, symptom control, and health-related quality of life (HRQoL) among adults with asthma. METHODS: Thirty-four patients were randomly assigned to the intervention group and thirty-two to the control group in this study. A tailored 50-minute intervention based on the contents of self-monitoring and action plans developed by the National Heart Lung and Blood Institute was provided to the intervention group...
October 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29138431/modelling-the-effect-of-beliefs-about-asthma-medication-and-treatment-intrusiveness-on-adherence-and-preference-for-once-daily-vs-twice-daily-medication
#4
Sarah Chapman, Peter Dale, Henrik Svedsater, Gillian Stynes, Nicola Vyas, David Price, Rob Horne
People with asthma who do not adhere to their maintenance medication may experience poorer asthma control and need more healthcare support than those who adhere. People (N = 1010) aged 18-55 years with self-reported asthma, taking one or more asthma maintenance medication(s), from five European countries, participated in a survey using validated scales (Medication Adherence Report Scale [MARS], Asthma Control Test™ [ACT], Beliefs about Medicine Questionnaire [BMQ] and the Asthma Treatment Intrusiveness Questionnaire [ATIQ])...
November 14, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29137124/asthmatic-patients-with-vitamin-d-deficiency-have-decreased-exacerbations-after-vitamin-replacement
#5
Paolo Solidoro, Michela Bellocchia, Ilaria Aredano, Alessio Mattei, Emanuele Pivetta, Filippo Patrucco, Monica Boita, Francesca de Blasio, Luisa Brussino, Giovanni Rolla, Caterina Bucca
BACKGROUND: Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL. METHODS: Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29135485/update-on-questionnaires-for-assessing-adherence-to-inhaler-devices-in-respiratory-patients
#6
Vicente Plaza
PURPOSE OF REVIEW: It has been estimated that adherence to inhaled medications in patients with asthma and chronic obstructive pulmonary disease (COPD) is around 50%. This low adherence rate increases morbidity and mortality of these disorders. The objective of this review was to update information on main questionnaires used in daily for assessing adherence to inhalers of patients with chronic respiratory diseases. RECENT FINDINGS: The test of the adherence to inhalers (TAI) is a recently developed and validated 12-item questionnaire to assess adherence to inhalers of aerosolized drugs in patients with asthma or COPD...
November 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29135394/real-life-profile-of-asthma-and-chronic-obstructive-pulmonary-disease-patients-in-turkey
#7
Zeynep Mısırlıgil, Arif Çımrın, Hakan Günen, Tevfik Özlü, Aykut Çilli, Levent Akyıldız, Hasan Bayram, Bilun Gemicioğlu, Esra Uzaslan, Öznur Abadoğlu, Mecit Suerdem
Introduction: Despite the presentation of similar symptoms, the airway diseases have different underlying pathophysiological processes and must be distinguished to enable the administration of appropriate treatment. In several studies the clinician- and patient-related causes of poor compliance to treatment in asthma/chronic obstructive pulmonary disease (COPD) patients have been evaluated. This study aimed to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naïve asthma and COPD patients in Turkey...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29119403/evaluation-of-the-efficiency-of-single-inhaler-combination-therapy-with-budesonide-formoterol-fumarate-in-patients-with-bronchial-asthma-in-daily-clinical-practice
#8
Michał Pirożyński, Piotr Hantulik, Agnieszka Almgren-Rachtan, Jerzy Chudek
INTRODUCTION: The effectiveness of single-inhaler budesonide/formoterol fumarate combination therapy for asthma has been previously shown for the original product. The aim of this nonrandomized, open-label, postauthorization efficacy study (PAES) real-life clinical assessment was to evaluate the clinical effectiveness of a second product (Bufomix Easyhaler(®)) in the daily clinical practice of asthma therapy. METHODS: This multicenter PAES was conducted by 220 unselected allergologists and pulmonologists who enrolled 2200 adult outpatients (age 49...
November 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29100941/impact-of-clinical-pharmacist-services-delivered-via-telemedicine-in-the-outpatient-or-ambulatory-care-setting-a-systematic-review
#9
REVIEW
Joshua D Niznik, Harvey He, Sandra L Kane-Gill
BACKGROUND: Utilization of telemedicine allows pharmacists to extend the reach of clinical interventions, connecting them with patients and providers, but the overall impact of these services is under-studied. OBJECTIVE: Identify the impact of clinical pharmacist telemedicine interventions on clinical outcomes, subsequently defined as clinical disease management, patient self-management, and adherence, in outpatient or ambulatory settings. METHODS: A literature search was conducted from database inception through May 2016 in Medline, SCOPUS, and EMBASE...
October 28, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29076829/comparative-effectiveness-trials-in-asthma-how-will-i-recognize-one
#10
Sharmilee M Nyenhuis, Andrea J Apter, Michael Schatz, Jerry A Krishnan
PURPOSE OF REVIEW: Comparative efficacy trials are designed to evaluate the harms and benefits of health care in a research environment. There is increasing interest in the results of comparative effectiveness trials, which are intended to fill gaps in evidence to inform decision-making in real-life clinical environments. The objective of this report is to review various tools to classify trials along the efficacy to effectiveness continuum. RECENT FINDINGS: Three tools [Pragmatic-Explanatory Continuum Indicator Summary (PRECIS), PRECIS-2, and PRAgmatic Clinical Trial Assessment Scale (PRACTAS)] are available that use a star diagram to illustrate where each element of a clinical trial design falls along the efficacy to effectiveness continuum (e...
October 25, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29075362/psychological-and-lifestyle-risk-factors-for-asthma-exacerbations-and-morbidity-in-children
#11
REVIEW
Alyssa A Oland, Genery D Booster, Bruce G Bender
Asthma is the most common childhood illness and disproportionately affects low-income, minority children who live in urban areas. A range of risk factors are associated with asthma morbidity and mortality, such as treatment non-adherence, exposure to environmental triggers, low-income households, exposure to chronic stress, child psychological problems, parental stress, family functioning, obesity, physical inactivity, and unhealthy diets. These risk factors often have complex interactions and inter-relationships...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29072882/rita-the-italian-severe-uncontrolled-asthma-registry
#12
Sara Maio, Sandra Baldacci, Megon Bresciani, Marzia Simoni, Manuela Latorre, Nicola Murgia, Fabrizio Spinozzi, Mariachiara Braschi, Leonardo Antonicelli, Barbara Brunetto, Patrizia Iacovacci, Paolo Roazzi, Carlo Pini, Mario Pata, Lidia La Grasta, Pierluigi Paggiaro, Giovanni Viegi
BACKGROUND: The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. METHODS: 493 adult patients from 27 Italian centres (recruited in 2011-2014) were analyzed. RESULTS: Mean age was 53.8yrs. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40yrs); the mean age for asthma symptoms onset was 30...
October 26, 2017: Allergy
https://www.readbyqxmd.com/read/29071077/assessing-the-use-of-breathesmart%C3%A2-mobile-technology-in-adult-patients-with-asthma-a-remote-observational-study
#13
Emilie Melvin, Anna Cushing, Anne Tam, Ruri Kitada, Melissa Manice
INTRODUCTION: Non-adherence to asthma daily controller medications is a common problem, reported to be responsible for 60% of asthma-related hospitalisations. The mean level of adherence for asthma medications is estimated to be as low as 22%. Therefore, objective measurements of adherence to medicine are necessary. This virtual observational study is designed to measure the usability of an electronic monitoring device platform that measures adherence. Understanding how patients use the BreatheSmart mobile technology at home is essential to assess its feasibility as a solution to improve medication adherence...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29061556/impact-of-an-electronic-monitoring-intervention-to-improve-adherence-to-inhaled-medication-in-patients-with-asthma-and-chronic-obstructive-pulmonary-disease-study-protocol-for-a-randomized-controlled-trial
#14
Claudia Gregoriano, Thomas Dieterle, Selina Dürr, Isabelle Arnet, Kurt E Hersberger, Jörg D Leuppi
BACKGROUND: Despite progress in pharmacological and non-pharmacological treatment in recent years, the burden of disease among patients with asthma and chronic obstructive pulmonary disease (COPD) is high and patients are frequently hospitalized due to exacerbations. Reasons for uncontrolled diseases are manifold, but are often associated with poor inhalation technique and non-adherence to the prescribed treatment plan. This causes substantial mortality, morbidity, and costs to the healthcare system...
October 23, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29060130/asthma-academy-developing-educational-technology-to-improve-asthma-medication-adherence-and-intervention-efficiency
#15
Aiswaria S Nair, Karen DeMuth, Chih-Wen Cheng, May D Wang
Asthma is a leading chronic disorder among children and adolescents. Although some children outgrow asthma while transitioning into adulthood, there are others who continue to suffer from life-threatening asthmatic exacerbations. Teenagers tend to have certain misconceptions about their asthmatic condition and treatment which are rarely recognized or addressed in regular clinical consultations. After reviewing the literature in this field, we have identified that improving patient knowledge can be effective in augmenting engagement, and considerably improving their clinical outcomes...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055500/long-term-systemic-corticosteroid-exposure-a-systematic-literature-review
#16
REVIEW
J Bradford Rice, Alan G White, Lauren M Scarpati, George Wan, Winnie W Nelson
PURPOSE: While corticosteroids are relatively inexpensive and commonly used as treatment for a variety of conditions, long-term use is known to be associated with certain toxicities. Prior systematic reviews have revealed an increased risk for costly adverse events (AEs), including bone fracture, infection, and gastrointestinal bleeding. The objective of this study was to conduct a systematic literature review of recent publications on the burden of long-term corticosteroid exposure, specifically, to summarize the AEs and economic impact of long-term corticosteroid use and to reveal data gaps for additional research...
October 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29052915/disease-burden-of-mild-asthma-in-china
#17
Bo Ding, Mark Small
BACKGROUND AND OBJECTIVE: The impact, treatment patterns and control of mild asthma are poorly understood for Chinese patients. This study describes the characteristics, therapeutic interventions and burden of mild asthma on patients residing in major cities of China. METHODS: The Respiratory Disease Specific Program 2015, a cross-sectional survey, was conducted with Chinese physicians and their patients. The survey assessed clinical characteristics, asthma symptoms, exacerbations, rescue inhaler usage, treatment adherence, asthma control, work and activity impairments and healthcare utilization for patients prescribed Global Initiative for Asthma (GINA) Step 1 or 2 treatment defined mild asthma...
October 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29046815/non-adherence-to-inhalational-medications-and-associated-factors-among-patients-with-asthma-in-a-referral-hospital-in-ethiopia-using-validated-tool-tai
#18
Asnakew Achaw Ayele, Henok Getachew Tegegn
BACKGROUND: Asthma is a chronic inflammatory condition of the airways that affects roughly 358 million people globally. It is a serious global health problem with an increasing prevalence worldwide. Most people affected are in low- and middle-income countries including Ethiopia. The association between non -adherence and poor disease control is clearly stated in different literatures. The main objective of the present study was to assess self-reported non- adherence level and to identify the potential factors associated with non-adherence...
2017: Asthma research and practice
https://www.readbyqxmd.com/read/29046189/high-adherence-to-subcutaneous-immunotherapy-in-a-real-life-study-from-a-large-tertiary-medical-center
#19
Aslı Gelincik, Semra Demir, Müge Olgaç, Halim İşsever, Bayerma Khishigsuren, Ferhan Özşeker, Bahauddin Çolakoğlu, Suna Büyüköztürk
BACKGROUND: Studies on real-life adherence to subcutaneous allergen immunotherapy (SCIT) for respiratory allergy are scarce. The aim of this study was to evaluate adherence to SCIT. METHODS: The patients prescribed SCIT for allergic rhinitis and/or asthma in 2009-2011 were contacted in 2014 and asked whether they completed at least the 3 years of SCIT and/or whether they suspended the treatment for at least 2 months. The Total Symptom Score-6, visual analog scale (VAS), asthma control test (ACT), medication scores, quality of life (QoL) scores, and immunotherapy satisfaction scores with VAS obtained before the initiation of SCIT in the first year and at the end of SCIT were compared...
November 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29036020/novel-methods-for-device-and-adherence-monitoring-in-asthma
#20
Matteo Bonini, Omar S Usmani
PURPOSE OF REVIEW: The article aims to provide an updated and evidence-based review of the innovative electronic health interventions to monitor and improve inhaler technique and adherence to recommended therapy in asthma. RECENT FINDINGS: Out of the 290 articles identified by the search strategy, 23 manuscripts fulfilled the review inclusion criteria. Included studies mainly addressed m-health, electronic reminders, telemedicine, and inhaler tracker interventions...
October 13, 2017: Current Opinion in Pulmonary Medicine
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