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Interleukin-18

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https://www.readbyqxmd.com/read/29036979/-role-of-ash2-absent-small-or-homeotic-like-and-jumonji-domain-containing-protein-3-on-histone-methylation-of-interferon-gamma-gene-and-their-associations-with-vascular-damage-of-kawasaki-disease
#1
J H Mei, G Tang, Q Wang, P Q Wen, M G Xu, D Cui, D L Ma, C Liu, G B Wang
Objective: To investigate the impacts of ash2 (absent, small, or homeotic)-like (Ash2L) and Jumonji domain-containing protein 3 (Jmjd3) on histone methylation of interferon-gamma(IFN-γ) gene and association with vascular damage of Kawasaki disease (KD) in acute phase. Methods: This study was performed among 36 children with KD in acute phase (KD group) and 28 age-matched health children (control group), who were treated or underwent physical examination in our hospital between February 2015 and June 2016. Patients were further divided into KD groups with or without coronary artery lesions (KD-CAL(+) , 16 cases; KD-CAL(-), 20 cases)...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29026368/serum-protein-pattern-associated-with-organ-damage-and-lupus-nephritis-in-systemic-lupus-erythematosus-revealed-by-pea-immunoassay
#2
Anna Petrackova, Andrea Smrzova, Petr Gajdos, Marketa Schubertova, Petra Schneiderova, Pavel Kromer, Vaclav Snasel, Martina Skacelova, Frantisek Mrazek, Josef Zadrazil, Pavel Horak, Eva Kriegova
BACKGROUND: Systemic lupus erythematosus (SLE) is a remarkably heterogeneous autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns in severe SLE phenotypes is still limited. We investigated the serum protein pattern of SLE, with special emphasis on irreversible organ damage and active lupus nephritis (LN) as assessed by renal Systemic Lupus Erythematosus Disease Activity Index. METHODS: We used proximity extension immunoassay (PEA, Proseek Multiplex, Olink) to assess the serum levels of ninety-two inflammation-related proteins in Czech patients with SLE (n = 75) and age-matched healthy control subjects (n = 23)...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/29018537/safety-pharmacokinetics-and-pharmacodynamics-of-amg-811-an-anti-interferon-%C3%AE-monoclonal-antibody-in-sle-subjects-without-or-with-lupus-nephritis
#3
Michael J Boedigheimer, David A Martin, Zahir Amoura, Jorge Sánchez-Guerrero, Juanita Romero-Diaz, Alan Kivitz, Cynthia Aranow, Tak Mao Chan, Yip Boon Chong, Kit Chiu, Christine Wang, Winnie Sohn, Gregory E Arnold, Michael A Damore, Andrew A Welcher, Barbara A Sullivan, Brian L Kotzin, James B Chung
OBJECTIVE: To evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with lupus nephritis (LN). METHODS: In this phase Ib, randomised, multiple-dose escalation study (NCT00818948), subjects without LN were randomised to subcutaneous AMG 811 (6, 20 or 60 mg) or placebo and subjects with LN were randomised to subcutaneous AMG 811 (20, 60 or 120 mg) or placebo every four weeks for three total doses...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29017770/longitudinal-analysis-of-serum-interleukin-18-in-patients-with-familial-mediterranean-fever-carrying-mefv-mutations-in-exon-10
#4
Taizo Wada, Tomoko Toma, Hanae Miyazawa, Eiko Koizumi, Tetsujiro Shirahashi, Yusuke Matsuda, Akihiro Yachie
BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to those without exon 10 mutations. However, longitudinal changes of serum IL-18 in FMF have not been fully characterized. METHODS: We serially evaluated serum levels of pro-inflammatory cytokines, including IL-18, in 12 patients with FMF carrying exon 10 mutations, all of whom showed typical FMF attacks...
October 7, 2017: Cytokine
https://www.readbyqxmd.com/read/29017651/-influence-of-rhubarb-extract-on-the-expression-of-ngal-and-il-18-in-the-kidney-of-rabbits-after-cpr
#5
Yong Dong, Jingqiong Zhan, Wen Xu, Xizhou Zhang
OBJECTIVE: To study the preventive effect and mechanism of Rhubarb extract on renal injury after cardiopulmonary resuscitation (CPR) in rabbits with cardiac arrest (CA). METHODS: Twenty-four male Japanese big-ear rabbits were divided into sham operation group, CPR model group and Rhubarb pretreatment group by random number table method, with 8 rabbits in each group. The rabbits in Rhubarb pretreatment group were treated with Rhubarb extract 5 mL×kg(-1)×d(-1) for 7 days; and those in sham operation group and CPR model group were fed with 0...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28992480/zearalenone-zea-induced-intestinal-inflammation-is-mediated-by-the-nlrp3-inflammasome
#6
Wentao Fan, Yanan Lv, Shuai Ren, Manyu Shao, Tongtong Shen, Kehe Huang, Jiyong Zhou, Liping Yan, Suquan Song
To ascertain whether zearalenone (ZEA) could induce intestinal inflammation and investigate its possible mechanism, we investigated inflammatory cytokine release and the activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First, intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice were fed a gavage of ZEA, and the disease activity indices (DAIs) and histological analysis were used to assess intestinal inflammation...
September 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28990414/biomarkers-of-endothelial-renal-and-platelet-dysfunction-in-stage-5-chronic-kidney-disease-hemodialysis-patients-with-heart-failure
#7
Ryan McMillan, Leonidas Skiadopoulos, Debra Hoppensteadt, Nil Guler, Vinod Bansal, Ravipresenna Parasuraman, Jawed Fareed
The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers-kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase-associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan-were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28979774/early-detection-of-acute-cisplatin-nephrotoxicity-interest-of-urinary-monitoring-of-proximal-tubular-biomarkers
#8
Valérian Bunel, Yasmina Tournay, Thomas Baudoux, Eric De Prez, Marie Marchand, Zita Mekinda, Raphaël Maréchal, Thierry Roumeguère, Marie-Hélène Antoine, Joëlle L Nortier
BACKGROUND: Renal toxicity induced by cisplatin (CisPt) is a clinical issue in patients with or without chronic kidney disease (CKD). Proximal tubular injury can result in acute kidney injury (AKI), which may compromise the course of chemotherapy and the prognosis. The purpose of this study was to investigate the time course of urinary markers of acute tubulotoxicity and to assess the usefulness of such monitoring in a routine clinical setting. METHODS: This work is an open prospective pilot study carried out among 23 patients receiving a platinum-based chemotherapy...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28973736/interleukin-18-rs187238-and-glucose-transporter-4-rs5435-polymorphisms-in-euro-brazilians-with-type-1-diabetes
#9
Y Al-Lahham, A K B Mendes, E M Souza, D Alberton, F G M Rego, G Valdameri, G Picheth
Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose transporter and has been associated with various diseases, including diabetes mellitus. We investigated the association of the polymorphisms rs187238 (IL-18) and rs5435 (GLUT4) in a case-control study in Euro-Brazilians with T1D (N = 136) and healthy subjects (N = 144)...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28957823/nlrc4-inflammasomopathies
#10
Neil Romberg, Tiphanie P Vogel, Scott W Canna
PURPOSE OF REVIEW: The purpose of the review is to highlight developments in autoinflammatory diseases associated with gain-of-function mutations in the gene encoding NLR-family CARD-containing protein 4 (NLRC4), the NLRC4-inflammasomopathies. RECENT FINDINGS: Three years since the identification of the first autoinflammation with infantile enterocolitis (AIFEC) patients, there is an improved understanding of how the NLRC4 inflammasome and interleukin 18 (IL-18) contribute to gut inflammation in myeloid and also intestinal epithelial cells...
September 27, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28955343/inflammasomes-and-cancer-the-dynamic-role-of-the-inflammasome-in-tumor-development
#11
REVIEW
Melvin Kantono, Beichu Guo
Chronic Inflammation in tumor microenvironments is not only associated with various stages of tumor development, but also has significant impacts on tumor immunity and immunotherapy. Inflammasome are an important innate immune pathway critical for the production of active IL-1β and interleukin 18, as well as the induction of pyroptosis. Although extensive studies have demonstrated that inflammasomes play a vital role in infectious and autoimmune diseases, their role in tumor progression remains elusive. Multiple studies using a colitis-associated colon cancer model show that inflammasome components provide protection against the development of colon cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28938959/rheumatoid-arthritis-complicates-noninvasive-whole-blood-gene-expression-testing-for-coronary-artery-disease
#12
Ryan Jessee, Erica Peart, Phil Beineke, Steven Rosenberg, James A Wingrove, William E Kraus, Kim M Huffman
BACKGROUND: Our objective was to evaluate an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive coronary artery disease (CAD) in patients with rheumatoid arthritis (RA). METHODS: We evaluated 20 pairs of nondiabetic coronary patients with and without RA, selected by matching on age, sex, race, body mass index, tobacco use, and number of diseased coronary vessels. Peripheral blood gene expression levels of 23 CAD-associated genes were measured, and a previously validated CAD risk score including age, sex, and gene expression levels (Corus CAD) was computed...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28934294/immunopathology-of-childhood-celiac-disease-key-role-of-intestinal-epithelial-cells
#13
Grzegorz Pietz, Rituparna De, Maria Hedberg, Veronika Sjöberg, Olof Sandström, Olle Hernell, Sten Hammarström, Marie-Louise Hammarström
BACKGROUND & AIMS: Celiac disease is a chronic inflammatory disease of the small intestine mucosa due to permanent intolerance to dietary gluten. The aim was to elucidate the role of small intestinal epithelial cells in the immunopathology of celiac disease in particular the influence of celiac disease-associated bacteria. METHODS: Duodenal biopsies were collected from children with active celiac disease, treated celiac disease, and clinical controls. Intestinal epithelial cells were purified and analyzed for gene expression changes at the mRNA and protein levels...
2017: PloS One
https://www.readbyqxmd.com/read/28910918/-advances-in-the-role-of-interleukin-18-in-acute-respiratory-distress-syndrome
#14
W Tan, P Jiang
No abstract text is available yet for this article.
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28902711/triggering-of-inflammasome-by-impaired-autophagy-in-response-to-acute-experimental-parkinson-s-disease-involvement-of-the-pi3k-akt-mtor-pathway
#15
Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
Several lines of evidence suggest that the inflammasome activation is involved in the progression of neurodegenerative diseases. However, the relation between Parkinson's disease (PD) and the inflammasome is still unclear. This study was designed to assess the involvement of inflammasome in acute experimental PD. Specifically, acute PD was induced in C57BL/6 mice by an injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). At seven days from MPTP induction, mice were euthanized and the midbrains were sampled to carry out immunohistochemical evaluations and western blot analysis...
October 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28889816/first-stage-palliation-strategy-for-univentricular-heart-disease-may-impact-risk-for-acute-kidney-injury
#16
Bryan H Goldstein, Stuart L Goldstein, Prasad Devarajan, Farhan Zafar, David M Kwiatkowski, Bradley S Marino, David L S Morales, Catherine D Krawczeski, David S Cooper
OBJECTIVE: Norwood palliation for patients with single ventricle heart disease is associated with a significant risk for acute kidney injury, which portends a worse prognosis. We sought to investigate the impact of hybrid stage I palliation (Hybrid) on acute kidney injury risk. DESIGN: This study is a single-centre prospective case-control study of seven consecutive neonates with single ventricle undergoing Hybrid palliation. Levels of serum creatinine and four novel urinary biomarkers, namely neutrophil gelatinase-associated lipocalin, interleukin-18, liver fatty acid-binding protein, and kidney injury molecule-1, were obtained before and after palliation...
September 11, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28860220/interleukin-18-enhances-vascular-calcification-and-osteogenic-differentiation-of-vascular-smooth-muscle-cells-through-trpm7-activation
#17
Kun Zhang, Yinyin Zhang, Weijing Feng, Renhua Chen, Jie Chen, Rhian M Touyz, Jingfeng Wang, Hui Huang
OBJECTIVE: Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors VC while TRPM7 (transient receptor potential melastatin 7) channel upregulation inhibits VC. However, the relationship between IL-18 and TRPM7 is unclear. We questioned whether IL-18 enhances VC and osteogenic differentiation of VSMCs through TRPM7 channel activation...
October 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28844586/performance-of-serum-creatinine-and-kidney-injury-biomarkers-for-diagnosing-histologic-acute-tubular-injury
#18
Dennis G Moledina, Isaac E Hall, Heather Thiessen-Philbrook, Peter P Reese, Francis L Weng, Bernd Schröppel, Mona D Doshi, F Perry Wilson, Steven G Coca, Chirag R Parikh
BACKGROUND: The diagnosis of acute kidney injury (AKI), which is currently defined as an increase in serum creatinine (Scr) concentration, provides little information on the condition's actual cause. To improve phenotyping of AKI, many urinary biomarkers of tubular injury are being investigated. Because AKI cases are not frequently biopsied, the diagnostic accuracy of concentrations of Scr and urinary biomarkers for histologic acute tubular injury is unknown. STUDY DESIGN: Cross-sectional analysis from multicenter prospective cohort...
August 23, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28838147/specific-biomarkers-associated-with-neurological-complications-and-congenital-central-nervous-system-abnormalities-from-zika-virus-infected-patients-in-brazil
#19
Yiu-Wing Kam, Juliana Almeida Leite, Fok-Moon Lum, Jeslin J L Tan, Bernett Lee, Carla C Judice, Daniel Augusto de Toledo Teixeira, Robert Andreata-Santos, Marco A Vinolo, Rodrigo Angerami, Mariangela Ribeiro Resende, Andre Ricardo Ribas Freitas, Eliana Amaral, Renato Passini Junior, Maria Laura Costa, José Paulo Guida, Clarice Weis Arns, Luis Carlos S Ferreira, Laurent Rénia, Jose Luiz Proença-Modena, Lisa F P Ng, Fabio T M Costa
Background: Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations. Methods: We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas, Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization...
July 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28832763/methotrexate-associated-to-lipid-core-nanoparticles-improves-cardiac-allograft-vasculopathy-and-the-inflammatory-profile-in-a-rabbit-heart-graft-model
#20
A I Fiorelli, D D Lourenço-Filho, E R Tavares, P O Carvalho, A F Marques, P S Gutierrez, R C Maranhão, N A G Stolf
Coronary allograft vasculopathy is an inflammatory-proliferative process that compromises the long-term success of heart transplantation and has no effective treatment. A lipid nanoemulsion (LDE) can carry chemotherapeutic agents in the circulation and concentrates them in the heart graft. The aim of the study was to investigate the effects of methotrexate (MTX) associated to LDE. Rabbits fed a 0.5% cholesterol diet and submitted to heterotopic heart transplantation were treated with cyclosporine A (10 mg·kg-1·day-1 orally) and allocated to treatment with intravenous LDE-MTX (4 mg/kg, weekly, n=10) or with weekly intravenous saline solution (control group, n=10), beginning on the day of surgery...
August 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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