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Interleukin-18

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https://www.readbyqxmd.com/read/27930489/screening-and-preliminary-verification-of-a-phage-display-single-chain-antibody-library-against-coal-workers-pneumoconiosis
#1
Guang-Hui Zhang, Li Li, Changfu Hao, Jing-Chao Ren, Hongyi Zhang, Jie Jiao, Liyun Gao, Shibin Ding, Sanqiao Yao, Wu Yao, Weidong Wu
OBJECTIVES: To construct a phage display human antibody library (PDHAL) against pneumoconiosis for the diagnosis and treatment of coal worker pneumoconiosis (CWP). METHODS: The PDHAL was established via CWP blood and six positive antibodies were discovered. 867 coal workers (558 CWP and 309 without CWP) and 393 controls were recruited to validate the results. RESULTS: A PDHAL against CWP was established, from which six strong positive clones were selected, sequenced and identified as VEGF, interleukin-18, HSP70, HER3, Gz-B and RF...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27927859/systemic-elevation-of-proinflammatory-interleukin-18-in-hiv-hcv-coinfection-versus-hiv-or-hcv-monoinfection
#2
Rebecca T Veenhuis, Jacquie Astemborski, Michael A Chattergoon, Paige Greenwood, Marissa Jarosinski, Richard D Moore, Shruti H Mehta, Andrea L Cox
BACKGROUND: HIV/HCV coinfection and elevated interleukin (IL)-18 levels are both associated with enhanced progression of hepatic inflammation and increased risk of diabetes, kidney disease, and cardiovascular disease. IL-18 is a proinflammatory cytokine made upon activation of the inflammasome, an innate sensing system. We assessed whether increased IL-18 could explain the increased incidence and progression of inflammatory conditions seen with HIV/HCV coinfection. METHODS: Serum from 559 subjects with HIV monoinfection, HCV monoinfection, HIV/HCV coinfection, or people who inject drugs with neither infection was tested for IL-18 by ELISA and for 16 other analytes by electrochemiluminescence immunoassay...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27913952/association-of-interleukin-18-and-asthma
#3
REVIEW
Ming-Hui Xu, Feng-Lai Yuan, Shu-Jing Wang, Hui-Ying Xu, Cheng-Wan Li, Xiao Tong
Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells. Recent work identified an IL-18 association with the pathogenesis of asthma, wherein increased IL-18 expression was found in the serum of patients...
December 2, 2016: Inflammation
https://www.readbyqxmd.com/read/27900002/therapeutic-targeting-of-liver-cancer-with-a-recombinant-dna-vaccine-containing-the-hemagglutinin-neuraminidase-gene-of-newcastle-disease-virus-via-apoptotic-dependent-pathways
#4
Li-Gang Chen, Yuan-Sheng Liu, Tang-Hui Zheng, Xu Chen, Ping Li, Chuan-Xing Xiao, Jian-Lin Ren
A total of ~38.6 million mortalities occur due to liver cancer annually, worldwide. Although a variety of therapeutic methods are available, the efficacy of treatment at present is extremely limited due to an increased risk of malignancy and inherently poor prognosis of liver cancer. Gene therapy is considered a promising option, and has shown notable potential for the comprehensive therapy of liver cancer, in keeping with advances that have been made in the development of cancer molecular biology. The present study aimed to investigate the synergistic effects of the abilities of the hemagglutinin neuraminidase protein of Newcastle disease virus (NDV), the pro-apoptotic factor apoptin from chicken anaemia virus, and the interferon-γ inducer interleukin-18 (IL-18) in antagonizing liver cancer...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895465/oncolytic-adenovirus-expressing-interleukin-18-improves-antitumor-activity-of-dacarbazine-for-malignant-melanoma
#5
Chunhua Yang, Hang Cao, Ning Liu, Kai Xu, Meng Ding, Li-Jun Mao
Conditionally replicating adenoviruses have emerged as novel therapeutic agents for cancer. This study aimed to evaluate synergistic antitumor activity of replication-competent adenovirus armed with interleukin (IL)-18 (ZD55-IL-18) and dacarbazine (DTIC) against melanoma. Melanoma A375 cells or nude mouse tumor xenografts were treated with ZD55-IL-18 alone or together with DTIC. The results showed that ZD55-IL-18 competently replicated in A375 cells and expressed IL-18, and these were not affected by DTIC. ZD55-IL-18 enhanced the cytotoxicity of DTIC accompanied by increased apoptosis...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27888626/interleukin-18-deteriorates-fabry-cardiomyopathy-and-contributes-to-the-development-of-left-ventricular-hypertrophy-in-fabry-patients-with-gla-ivs4-919-g-a-mutation
#6
Yueh Chien, Chian-Shiu Chien, Huai-Chih Chiang, Wei-Lin Huang, Shih-Jie Chou, Wei-Chao Chang, Yuh-Lih Chang, Hsin-Bang Leu, Kuan-Hsuan Chen, Kang-Ling Wang, Ying-Hsiu Lai, Yung-Yang Liu, Kai-Hsi Lu, Hsin-Yang Li, Yen-Jen Sung, Yuh-Jyh Jong, Yann-Jang Chen, Chung-Hsuan Chen, Wen-Chung Yu
RATIONALE: A high incidence of GLA IVS4+919 G>A mutation in patients with Fabry disease of the later-onset cardiac phenotype, has been reported in Taiwan. However, suitable biomarkers or potential therapeutic surrogates for Fabry cardiomyopathy (FC) in such patients under enzyme replacement treatment (ERT) remain unknown. OBJECTIVE: Using FC patients carrying IVS4+919 G>A mutation, we constructed an induced pluripotent stem cell (iPSC)-based disease model to investigate the pathogenetic biomarkers and potential therapeutic targets in ERT-treated FC...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27881017/association-between-interleukin-18-variants-and-prostate-cancer-in-slovak-population
#7
J Jurecekova, E Babusikova, M Kmetova Sivonova, H Drobkova, M Petras, J Kliment, E Halasova
Interleukin-18 (IL-18), pro-inflammatory cytokine, plays important role in antitumor immunity. Polymorphisms in the IL-18 gene may lead to its altered production/activity and such modulate susceptibility to prostate cancer. The aim of this study was to evaluate the relationship between the -607 and +105 polymorphisms in the IL-18 gene and the risk of prostate cancer development and progression in Slovak population. The study was performed using 425 patients with prostate cancer, 270 patients with benign prostatic hyperplasia (BHP) and 263 healthy male controls...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27876626/life-threatening-nlrc4-associated-hyperinflammation-successfully-treated-with-interleukin-18-inhibition
#8
Scott W Canna, Charlotte Girard, Louise Malle, Adriana de Jesus, Neil Romberg, Judith Kelsen, Lea F Surrey, Pierre Russo, Andrew Sleight, Eduardo Schiffrin, Cem Gabay, Raphaela Goldbach-Mansky, Edward M Behrens
NLRC4-inflammasome hyperactivity causes infantile-onset Macrophage Activation Syndrome and enterocolitis with extraordinary serum IL-18 elevation (NLRC4-MAS). Herein, we report a critically ill infant with severe, refractory NLRC4-MAS who showed sustained response to treatment with experimental IL-18 inhibition.
November 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27864297/expression-of-biologically-active-murine-interleukin-18-il-18-in-lactococcus-lactis
#9
Sadegh Feizollahzadeh, Hossein Khanahmad, Ilnaz Rahimmanesh, Mazdak Ganjalikhani-Hakemi, Alireza Andalib, Mohammad Hossein Sanei, Abbas Rezaei
Food grade bacterium Lactococcus lactis is increasingly used for heterologous protein expression in therapeutic and industrial applications. The ability of L. lactis to secrete biologically active cytokines may be used for the generation of therapeutic cytokines. Interleukin (IL)-18 enhances the immune response, especially on mucosal surfaces, emphasizing its therapeutic potential. However, it is produced as an inactive precursor and has to be enzymatically cleaved for maturation. We genetically manipulated L...
November 17, 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27859256/proinflammatory-effect-of-hmgb1-on-keratinocytes-an-autocrine-mechanism-underlying-psoriasis-development
#10
Weigang Zhang, Sen Guo, Bing Li, Lin Liu, Rui Ge, Tianyu Cao, Huina Wang, Tianwen Gao, Gang Wang, Chunying Li
Psoriasis is an autoimmune skin disease, in which keratinocytes play a crucial pathogenic role. High-mobility group protein B1 (HMGB1) is an inflammatory factor that can be released from keratinocyte nuclei in psoriatic lesions. We aimed to investigate the proinflammatory effect of HMGB1 on keratinocytes and the contribution of HMGB1 to psoriasis development. Normal human keratinocytes were treated with recombinant human HMGB1, and the production of inflammatory factors and the intermediary signaling pathways were examined...
November 14, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27842498/least-absolute-shrinkage-and-selection-operator-type-methods-for-the-identification-of-serum-biomarkers-of-overweight-and-obesity-simulation-and-application
#11
Monica M Vasquez, Chengcheng Hu, Denise J Roe, Zhao Chen, Marilyn Halonen, Stefano Guerra
BACKGROUND: The study of circulating biomarkers and their association with disease outcomes has become progressively complex due to advances in the measurement of these biomarkers through multiplex technologies. The Least Absolute Shrinkage and Selection Operator (LASSO) is a data analysis method that may be utilized for biomarker selection in these high dimensional data. However, it is unclear which LASSO-type method is preferable when considering data scenarios that may be present in serum biomarker research, such as high correlation between biomarkers, weak associations with the outcome, and sparse number of true signals...
November 14, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27826889/osteoprotegerin-srankl-signaling-system-in-pulmonary-sarcoidosis-a-bronchoalveolar-lavage-study
#12
W Naumnik, B Naumnik, W Niklińska, M Ossolińska, E Chyczewska
Osteoprotegerin (OPG), a soluble tumor necrosis factor receptor family molecule, protects endothelial cells from apoptosis in vitro and promotes neovascularization in vivo. Angiogenesis may be crucial for the course and outcome of sarcoidosis. In this study, we evaluated the clinical usefulness of OPG and its ligand, a soluble receptor activator of nuclear factor-kappaB (sRANKL), in bronchoalveolar lavage fluid (BALF) in patients with sarcoidosis (BBS, Besniera-Boeck-Schaumann disease). We studied 22 BBS patients and 15 healthy volunteers as a control group...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27821270/bipolar-disorder-moderates-associations-between-linoleic-acid-and-markers-of-inflammation
#13
Ya-Wen Chang, Shervin Assari, Alan R Prossin, Laura Stertz, Melvin G McInnis, Simon J Evans
Dietary polyunsaturated fatty acids (PUFA) and inflammatory proteins associate with immune activation and have been implicated in the pathophysiology of mood disorders. We have previously reported that individuals with bipolar disorder (BPD) have decreased PUFA intake, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA); and decreased PUFA concentration of plasma EPA and linoleic acid (LA). We have also reported an association between plasma LA and its metabolites and burden of disease measures in BPD...
October 27, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27816188/delirium-in-patients-with-acute-ischemic-stroke-admitted-to-the-non-intensive-stroke-unit-incidence-and-association-between-clinical-features-and-inflammatory-markers
#14
Hasan Hüseyin Kozak, Faruk Uğuz, İbrahim Kılınç, Ali Ulvi Uca, Osman Serhat Tokgöz, Zehra Akpınar, Nejla Özer
BACKGROUND: Stroke patients with development of delirium have unfavorable outcomes, higher mortality, longer hospitalizations, and a greater degree of dependence after discharge. Studies suggest that delirium is associated with abnormal immunological responses and a resultant increase in inflammatory markers. OBJECTIVE: Our aim was to determine whether there is an entity relationship between delirium, inflammation and acute ischemic stroke (AIS). METHODS: Sixty AIS patients admitted to the hospital were consecutively recruited...
October 24, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27813570/effect-of-polymorphisms-in-interleukin-18-gene-on-the-susceptibility-to-coronary-artery-disease-in-a-chinese-population
#15
J B Ma, L Chen, B Gao, J Xu
Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were consecutively recruited from the First Hospital of Yulin between March 2013 and May 2015. The IL-18 -607A/C and -372C/G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism...
October 24, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27805275/what-s-new-in-atopic-eczema-an-analysis-of-systematic-reviews-published-in-2014-part-1-epidemiology-risk-factors-and-outcomes
#16
REVIEW
S J Hatfield, N K Rogers, A Lloyd-Lavery, D Grindlay, R Barnett, K S Thomas
This review summarizes key findings from nine systematic reviews on atopic eczema (AE) published or first indexed in 2014. It focuses on epidemiology, disease processes and methodological issues. There is reasonable evidence to conclude that high birth weight (> 4000 g) is a risk factor for the development of AE. A lower socioeconomic position is associated with lower prevalence of AE. The effect of exposure to traffic-related air pollution in childhood on the development of AE is uncertain. CD14 polymorphisms do not appear to have an effect in AE...
November 2, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27800521/continued-elevation-of-interleukin-18-and-interferon-%C3%AE-after-initiation-of-antiretroviral-therapy-and-clinical-failure-in-a-diverse-multicountry-human-immunodeficiency-virus-cohort
#17
Ashwin Balagopal, Nikhil Gupte, Rupak Shivakoti, Andrea L Cox, Wei-Teng Yang, Sima Berendes, Noluthando Mwelase, Cecilia Kanyama, Sandy Pillay, Wadzanai Samaneka, Breno Santos, Selvamuthu Poongulali, Srikanth Tripathy, Cynthia Riviere, Javier R Lama, Sandra W Cardoso, Patcharaphan Sugandhavesa, Richard D Semba, James Hakim, Mina C Hosseinipour, Nagalingeswaran Kumarasamy, Ian Sanne, David Asmuth, Thomas Campbell, Robert C Bollinger, Amita Gupta
Background.  We assessed immune activation after antiretroviral therapy (ART) initiation to understand clinical failure in diverse settings. Methods.  We performed a case-control study in ACTG Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS). Cases were defined as incident World Health Organization Stage 3 or 4 human immunodeficiency virus (HIV) disease or death, analyzed from ART weeks 24 (ART24) to 96. Controls were randomly selected. Interleukin (IL)-6, interferon (IFN)-γ-inducible protein-10, IL-18, tumor necrosis factor-α, IFN-γ, and soluble CD14 (sCD14) were measured pre-ART and at ART24 in plasma...
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27788716/-damage-associated-molecular-patterns-and-liver-failure
#18
Y Y Yan, S Lin, Y Y Zhu
Damage-associated molecular patterns (DAMPs) are a series of intracellular molecules with immunoregulatory activity which are released by the damaged or activated cells and can induce autoimmunity or immune tolerance via pattern recognition receptors. At present, the DAMPs which have been discovered include extracellular histone, high-mobility group box-1, chromosomal deoxyribonucleic acid, interleukin-18, interleukin-32, uric acid, and mitochondrial transcription factors. The discovery of DAMPs and clarification of their mechanisms of action help to know the pathophysiological process of liver failure and provide new thoughts for the diagnosis, prevention, and treatment of liver failure...
August 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27788160/storage-time-and-urine-biomarker-levels-in-the-assess-aki-study
#19
Kathleen D Liu, Edward D Siew, W Brian Reeves, Jonathan Himmelfarb, Alan S Go, Chi-Yuan Hsu, Michael R Bennett, Prasad Devarajan, T Alp Ikizler, James S Kaufman, Paul L Kimmel, Vernon M Chinchilli, Chirag R Parikh
BACKGROUND: Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood. METHODS: 866 subjects enrolled in the NIDDK-sponsored ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study were included. Samples were processed under standard conditions and stored at -70°C until analyzed. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and liver fatty acid binding protein (L-FABP) were measured in urine samples collected during the index hospitalization or an outpatient visit 3 months later...
2016: PloS One
https://www.readbyqxmd.com/read/27780404/autophagy-induced-by-axl-receptor-tyrosine-kinase-alleviates-acute-liver-injury-via-inhibition-of-nlrp3-inflammasome-activation-in-mice
#20
Jihye Han, Joonbeom Bae, Chang-Yong Choi, Sang-Pil Choi, Hyung-Sik Kang, Eun-Kyeong Jo, Jongsun Park, Young Sik Lee, Hyun-Seuk Moon, Chung-Gyu Park, Myung-Shik Lee, Taehoon Chun
Severe hepatic inflammation is a common cause of acute or chronic liver disease. Macrophages are one of the key mediators which regulate the progress of hepatic inflammation. Increasing evidence shows that the TAM (TYRO3, AXL and MERTK) family of RTKs (receptor tyrosine kinases), which is expressed in macrophages, alleviates inflammatory responses through a negative feedback loop. However, the functional contribution of each TAM family member to the progression of hepatic inflammation remains elusive. In this study, we explore the role of individual TAM family proteins during autophagy induction and evaluate their contribution to hepatic inflammation...
December 2016: Autophagy
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