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Interleukin-18

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https://www.readbyqxmd.com/read/29452878/combining-novel-renal-injury-markers-with-delta-serum-creatinine-early-after-cardiac-surgery-and-risk-stratification-for-serious-adverse-outcomes-an-exploratory-analysis
#1
David R McIlroy, David Farkas, Kun Pan, John W Pickering, H Thomas Lee
OBJECTIVE: To evaluate the prognostic utility of multiple novel urinary biomarkers of renal injury when used alone, in pair-wise combination with an early delta serum creatinine (ΔS Cr ) term, and combined as a broad biomarker panel for the prediction of serious adverse outcomes that may reflect AKI in patients undergoing cardiac surgery. DESIGN: Post-hoc analysis of prospective observational study. SETTING: Academic medical center. PARTICIPANTS: 603 adults undergoing cardiac surgery...
December 30, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29406994/corrigendum-to-endothelial-dysfunction-mediated-by-interleukin-18-in-patients-with-ischemic-heart-disease-undergoing-coronary-artery-bypass-grafting-surgery-med-hypotheses-104-2017-20-24
#2
J Sokolic, V Sotosek Tokmadzic, D Knezevic, I Medved, N Vukelic Damjani, S Balen, M Rakic, A Lanca Bastiancic, G Laskarin
No abstract text is available yet for this article.
February 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29394248/elevations-of-novel-cytokines-in-bacterial-meningitis-in-infants
#3
Lakshmi Srinivasan, Laurie Kilpatrick, Samir S Shah, Soraya Abbasi, Mary C Harris
BACKGROUND: Bacterial meningitis is challenging to diagnose in infants, especially in the common setting of antibiotic pre-treatment, which diminishes yield of cerebrospinal fluid (CSF) cultures. Prior studies of diagnostic markers have not demonstrated sufficient accuracy. Interleukin-23 (IL-23), interleukin-18 (IL-18) and soluble receptor for advanced glycation end products (sRAGE) possess biologic plausibility, and may be useful as diagnostic markers in bacterial meningitis. METHODS: In a prospective cohort study, we measured IL-23, IL-18 and sRAGE levels in CSF...
2018: PloS One
https://www.readbyqxmd.com/read/29381011/inflammasome-function-in-monocyte-subsets-and-a-risk-of-late-onset-sepsis-in-preterm-very-low-birth-weight-neonates
#4
Magdalena Zasada, Marzena Lenart, Magdalena Rutkowska-Zapała, Małgorzata Stec, Ola Czyz, Nina Mól, Maciej Siedlar, Przemko Kwinta
BACKGROUND: Immature immune systems predispose very low birth weight (VLBW) neonates to systemic infections in early life. Defective inflammasome function may increase a neonate's susceptibility to late-onset sepsis (LOS). METHODS: Blood samples were taken on the 5th day of life (DOL) for all VLBW neonates (non-LOS and before-LOS groups; n=76), and within 24 hours of sepsis onset (LOS group; n=39). Monocyte (MO) subsets and intracellular interleukin-1β (IL-1β) expression were analysed using flow cytometry...
January 29, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29376608/-biomarkers-of-acute-hypoxia-reoxygenation-injury-to-nercycites-during-laparoscopic-resection-of-renal-parenchyma
#5
S V Popov, R G Guseinov, A G Martov, T M Muratov, N B Tabynbaev
Intraoperative occlusion of the renal artery during laparoscopic partial nephrectomy results in warm ischemia and nonspecific hypoxia-reoxygenation alteration of the renal parenchyma cells with a predominant injury to epitheliocytes of the proximal segments of the tubular nephron system. The onset and development of acute kidney injury (AKI) syndrome, which requires immediate correction, is due to the typical pathological process of cell injury. In this regard, the issue of timely diagnosis of AKI remains highly relevant...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29376590/-effects-of-the-of-renal-warm-ischemia-time-on-the-recovery-of-filtration-function-in-the-experiment
#6
R G Guseinov, S V Popov, A N Gorshkov, K V Sivak, A G Martov
AIM: To investigate experimentally ultrastructural and biochemical signs of acute injury to the renal parenchyma after warm renal ischemia of various duration and subsequent reperfusion. MATERIALS AND METHODS: The experiments were performed on 44 healthy conventional female rabbits of the "Chinchilla" breed weighted 2.6-2.7 kg, which were divided into four groups. In the first, control, group included pseudo-operated animals. In the remaining three groups, an experimental model of warm ischemia of renal tissue was created, followed by a 60-minute reperfusion...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29375680/mitochondrial-factor-and-cell-cytokines-associate-with-tcm-syndrome-scale-in-vascular-dementia-patients
#7
Linjuan Sun
Mitochondrial factor and cell cytokines play important roles in the incidence of vascular dementia (VD), but their correlations with inflammatory and mitochondrial factors and the role of both in the kidney essence deficiency pattern and phlegm turbidity blocking orifice pattern are not clear. This study was aimed at studying the correlations between the serum mitochondrial factor and cell cytokines with TCM Syndrome Scale in vascular dementia. According to the inclusion criteria we collected 108 vascular dementia patients which were divided into the kidney essence deficiency pattern and phlegm turbidity blocking orifice pattern based on the TCM Syndrome Scale...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29371996/molecular-mechanism-of-atopic-dermatitis-induction-following-sensitization-and-challenge-with-2-4-dinitrochlorobenzene-in-mouse-skin-tissue
#8
JiYoun Kim, JaeHee Lee, SoJung Shin, AhRang Cho, Yong Heo
Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge...
January 2018: Toxicological Research
https://www.readbyqxmd.com/read/29371597/immunological-consequences-of-kidney-cell-death
#9
REVIEW
Maysa Sarhan, Anne von Mässenhausen, Christian Hugo, Rainer Oberbauer, Andreas Linkermann
Death of renal cells is central to the pathophysiology of acute tubular necrosis, autoimmunity, necrotizing glomerulonephritis, cystic kidney disease, urosepsis, delayed graft function and transplant rejection. By means of regulated necrosis, immunogenic damage-associated molecular patterns (DAMPs) and highly reactive organelles such as lysosomes, peroxisomes and mitochondria are released from the dying cells, thereby causing an overwhelming immunologic response. The rupture of the plasma membrane exhibits the "point of no return" for the immunogenicity of regulated cell death, explaining why apoptosis, a highly organized cell death subroutine with long-lasting plasma membrane integrity, elicits hardly any immune response...
January 25, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29353540/-express-involvement-of-neutrophils-and-interleukin-18-in-nociception-in-a-mouse-model-of-muscle-pain
#10
Shinichirou Yoshida, Yoshihiro Hagiwara, Masahiro Tsuchiya, Masamichi Shinoda, Masashi Koide, Hiroyasu Hatakeyama, Chayanit Chaweewannakorn, Toshihisa Yano, Yasuhito Sogi, Nobuyuki Itaya, Takuya Sekiguchi, Yutaka Yabe, Keiichi Sasaki, Makoto Kanzaki, Eiji Itoi
No abstract text is available yet for this article.
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29352570/the-nlrp3-inflammasome-and-the-emerging-role-of-colchicine-to-inhibit-atherosclerosis-associated-inflammation
#11
REVIEW
Gonzalo J Martínez, David S Celermajer, Sanjay Patel
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1β and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability...
December 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29349811/genetic-analysis-of-interleukin-18-gene-polymorphisms-in-alopecia-areata
#12
Sumeyya Deniz Celik, Omer Ates
BACKGROUND: Alopecia areata (AA), which appears as nonscarring hair shedding on any hair-bearing area, is a common organ-specific autoimmune condition. Cytokines have important roles in the development of AA. Interleukin (IL) 18 is a significant proinflammatory cytokine that was found higher in the patients with AA. We aimed to investigate whether the IL-18 (rs187238 and rs1946518) single nucleotide polymorphisms (SNPs) may be associated with AA and/or clinical outcome of patients with AA in Turkish population...
January 18, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29341496/association-of-genetic-variants-in-the-interleukin-18-gene-promoter-with-risk-of-hepatocellular-carcinoma-and-metastasis-in-patients-with-hepatitis-c-virus-infection
#13
Noha M Bakr, Ashraf Awad, Emad A Moustafa
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, characterized by high vascularization and rapid tumor progression. The current case-control study aimed to analyze the influence of -607C/A and -137G/C polymorphisms in the interleukin-18 (IL-18) promoter on the risk of HCC occurrence and metastasis in Egyptian patients infected with hepatitis C virus (HCV). Both genetic variations were genotyped in 279 subjects including HCV patients with and without HCC and unrelated healthy subjects, using the allele-specific polymerase chain reaction (AS-PCR) method...
February 2018: IUBMB Life
https://www.readbyqxmd.com/read/29340331/location-specific-oral-microbiome-possesses-features-associated-with-ckd
#14
Jianzhong Hu, Srinivas Iragavarapu, Girish N Nadkarni, Ruiqi Huang, Monica Erazo, Xiuliang Bao, Divya Verghese, Steven Coca, Mairaj K Ahmed, Inga Peter
Introduction: Chronic kidney disease (CKD), a progressive loss of renal function, can lead to serious complications if underdiagnosed. Many studies suggest that the oral microbiota plays important role in the health of the host; however, little is known about the association between the oral microbiota and CKD pathogenesis. Methods: In this study, we surveyed the oral microbiota in saliva, the left and right molars, and the anterior mandibular lingual area from 77 participants (18 with and 59 without CKD), and tested their association with CKD to identify microbial features that may be predictive of CKD status...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29326099/interleukin-18-diagnostically-distinguishes-and-pathogenically-promotes-human-and-murine-macrophage-activation-syndrome
#15
Eric S Weiss, Charlotte Girard-Guyonvarc'h, Dirk Holzinger, Adriana A de Jesus, Zeshan Tariq, Jennifer Picarsic, Eduardo J Schiffrin, Dirk Foell, Alexei A Grom, Sandra Ammann, Stephan Ehl, Tomoaki Hoshino, Raphaela Goldbach-Mansky, Cem Gabay, Scott W Canna
Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS) are life-threatening hyperferritinemic systemic inflammatory disorders. Though profound cytotoxic impairment causes familial HLH (fHLH), the mechanisms driving non-fHLH and MAS are largely unknown. MAS occurs in patients with suspected rheumatic disease, but the mechanistic basis for its distinction is unclear. Recently, a syndrome of recurrent MAS with infantile enterocolitis caused by NLRC4 inflammasome hyperactivity highlighted the potential importance of Interleukin (IL)-18...
January 11, 2018: Blood
https://www.readbyqxmd.com/read/29317576/-protective-effect-of-taxifolin-on-h2o2-induced-%C3%A2-h9c2-cell-pyroptosis
#16
Yanqiong Ye, Xiaoli Wang, Qian Cai, Jian Zhuang, Xiaohua Tan, Wei He, Mingyi Zhao
To explore the effect of taxifolin on H2O2-induced pyroptosis in H9C2 cells and the possible mechanisms.
 Methods: The H9C2 cells was divided into 3 groups: a control group, a hydrogen peroxide (H2O2)group and a taxifolin group. The morphology of H9C2 cells was observed by inverted phase contrast microscope. The mitochondrial membrane potential was measured by JC-1 staining and flow cytometry. The alteration of the level of reactive oxygen species (ROS) was detected by specific mitochondrial probe. The protein levels of cysteinyl aspartate specific proteinase-1 (caspase-1)was determined by Western blot...
December 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29307055/novel-acute-kidney-injury-biomarkers-their-characteristics-utility-and-concerns
#17
REVIEW
Braian M Beker, Mateo G Corleto, Cecilia Fieiras, Carlos G Musso
Acute kidney injury (AKI) consists of a rapid renal function decline which usually increases serum urea and creatinine levels. Since kidney injury begins by inducing biological and molecular changes which evolve to cellular damage, biomarkers could be used as tools for monitoring early AKI appearance, and predicting its recovery. Among the main AKI biomarkers the neutrophil gelatinase-associated lipocalin, cystatin C, kidney injury molecule-1, monocyte chemotactic peptide-1, N-acetyl-β-D-glucosaminidase, interleukin-18, liver-type fatty acid-binding protein, netrin-1, cycle arrest markers, endogenous ouabain, selenium-binding protein 1, and BPIFA2 marker, have been described...
January 6, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29299122/wnt-%C3%AE-catenin-and-hedgehog-pathways-are-involved-in-the-inflammatory-effect-of-interleukin-18-on-rat-chondrocytes
#18
Jiapeng Bao, Chiyuan Ma, Jisheng Ran, Yan Xiong, Shigui Yan, Lidong Wu
To investigate the inflammatory effect of Interleukin 18 (IL-18) on rat chondrocytes and the involvement of Wnt/β-catenin and Hedgehog pathways, the mRNA and protein level of matix-degrading enzymes (MMP-2, 3, 9,13 and aggrecanses) and chondrocyte-specific proteins (Collagen II and aggrecan) were evaluated by qRT-PCR and Western blot, and key protein level of Wnt/β-catenin and Hedgehog pathways including β-catenin, GSK-3β, DKK-1, IHH, SHH, and Gli-2 were evaluated by Western blot. Dickkopf-1 (DKK-1) and Cyclopamine were used as antagonist of Wnt/β-catenin and Hedgehog pathways to perform pathway inhibition tests...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297273/circulating-levels-of-interleukin-17a-tumor-necrosis-factor-alpha-interleukin-18-interleukin-10-and-cognitive-performance-of-patients-with-relapsing-remitting-multiple-sclerosis
#19
Anastasiya G Trenova, Georgi S Slavov, Milena N Draganova-Filipova, Nonka G Mateva, Mariya G Manova, Lyuba D Miteva, Spaska A Stanilova
Multiple sclerosis (MS) is associated with cytokine imbalance and high rate (40-70%) of cognitive impairment. The objective of this study is to investigate the relationship between serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-17A, IL-18, IL-10, and cognitive performance in patients with relapsing-remitting MS (RRMS). Methods The study comprised 159 patients with RRMS (mean age 40.08 ± 8.48 years) in remission phase and 86 age-, gender-, and education-matched healthy controls...
January 3, 2018: Neurological Research
https://www.readbyqxmd.com/read/29285382/il18-rs360719-a-g-il18r1-rs13015714-g-t-il18rap-rs917997-c-t-and-il28b-rs8099917-t-g-polymorphisms-and-risk-of-gastric-cardiac-adenocarcinoma
#20
Jun Yin, Changqing Dong, Weifeng Tang, Ruiping Liu, Suocheng Chen, Liang Zheng, Haiyong Gu
The present study was conducted to investigate the association between gastric cardiac adenocarcinoma (GCA) and four functional single-nucleotide polymorphisms (SNPs), including interleukin 18 (IL18) rs360719 A>G, IL18 receptor 1 (IL18R1) rs13015714 G>T, IL18 receptor accessory protein (IL18RAP) rs917997 C>T and interleukin 28B (IL28B) rs8099917 T>G variants. A hospital-based case-control study was performed to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study...
December 2017: Molecular and Clinical Oncology
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