keyword
https://read.qxmd.com/read/38535200/a-phase-i-iia-prospective-randomized-open-label-study-on-the-safety-and-efficacy-of-nebulized-liposomal-amphotericin-for-invasive-pulmonary-aspergillosis
#1
JOURNAL ARTICLE
Jesús Fortún, Elia Gómez-García de la Pedrosa, Alberto Martínez-Lorca, Patricia Paredes, Pilar Martín-Dávila, Alicia Gómez-López, María José Buitrago, Javier López-Jiménez, Francesca Gioia, Rosa Escudero, Maria Elena Alvarez-Alvarez, Cruz Soriano, Javier Moreno-García, Diana San Miguel, Noelia Vicente, Santiago Moreno
Although nebulized liposomal amphotericin B (NLAB) is being used in invasive pulmonary aspergillosis (IPA) prophylaxis, no clinical trial has shown its efficacy as a therapeutic strategy. NAIFI is the inaugural randomized, controlled clinical trial designed to examine the safety and effectiveness of NLAB (dosage: 25 mg in 6 mL, three times per week for 6 weeks) against a placebo, in the auxiliary treatment of IPA. Throughout the three-year clinical trial, thirteen patients (six NLAB, seven placebo) were included, with 61% being onco-hematological with less than 100 neutrophils/μL...
March 1, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38533326/-natronoglomus-mannanivorans-gen-nov-sp-nov-beta-1-4-mannan-utilizing-natronoarchaea-from-hypersaline-soda-lakes
#2
JOURNAL ARTICLE
Dimitry Y Sorokin, Alexander G Elcheninov, Nicole J Bale, Jaap S Sinninghe Damsté, Ilya V Kublanov
Beta-mannans are insoluble plant polysaccharides with beta-1,4-linked mannose as the backbone. We used three forms of this polysaccharide, namely, pure mannan, glucomannan, and galactomannan, to enrich haloarchaea, which have the ability to utilize mannans for growth. Four mannan-utilizing strains obtained in pure cultures were closely related to each other on the level of the same species. Furthermore, another strain selected from the same habitats with a soluble beta-1,4-glucan (xyloglucan) was also able to grow with mannan...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38519916/clinical-characteristics-diagnosis-treatment-and-outcome-of-patients-with-liver-abscess-due-to-aspergillus-spp-a-systematic-review-of-published-cases
#3
Igor Dumic, Enzo Marasco Caetano, Sidney Marcel Domingues, Ivana Pantic, Milan Radovanovic, Libardo Rueda Prada, Charles W Nordstrom, Marina Antic, Tamara Milovanovic, Magdalena Kotseva, Amteshwar Singh, Shweta Fnu
BACKGROUND: Aspergillus spp liver abscess is a relatively rare entity and thus far no systematic review has been performed examining patients' demographics, clinical manifestations, diagnosis, management, and outcome. METHODS: We performed a systematic review of the literature using MEDLINE and LILACS databases. We searched for articles published in the period from January 1990 to December 24, 2022, to identify patients who developed liver abscesses due to Aspergillus spp...
March 22, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38505289/diagnosis-and-management-of-invasive-fungal-diseases-in-non-neutropenic-icu-patients-with-focus-on-candidiasis-and-aspergillosis-a-comprehensive-review
#4
REVIEW
Afzal Azim, Armin Ahmed
Invasive fungal diseases pose a significant threat to non-neutropenic ICU patients, with Candida and Aspergillus infections being the most common. However, diagnosing these infections in the ICU population remains challenging due to overlapping clinical features, poor sensitivity of blood cultures, and invasive sampling requirements. The classical host criteria for defining invasive fungal disease do not fully apply to ICU patients, leading to missed or delayed diagnoses. Recent advancements have improved our understanding of invasive fungal diseases, leading to revised definitions and diagnostic criteria...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38479779/histoplasma-antigens-as-novel-players-for-the-development-of-new-enzyme-immunoassays-for-the-serodiagnosis-of-histoplasmosis-a-comparative-study-of-their-analytical-performance
#5
JOURNAL ARTICLE
Carolina Rodríguez Laboccetta, Víctor J Briceño Fernández, Agustín Videla Garrido, Gladys B Posse, María L Cuestas, Alejandro D Nusblat
Definitive diagnosis of histoplasmosis relies on culture and/or cytology/histopathology; however, these procedures have limited sensitivity and cultures are time-consuming. Antibodies detection by immunodiffusion has low sensitivity in immunocompromised individuals and uses histoplasmin (HMN), a crude antigenic extract, as reagent. Novel protein antigen candidates have been recently identified and produced by DNA-recombinant techniques to obtain standardized and specific reagents for diagnosing histoplasmosis...
March 13, 2024: Medical Mycology
https://read.qxmd.com/read/38479660/high-efficient-preparation-of-low-molecular-weight-galactomannan-from-leucaena-leucocephala-galactomannan-through-the-combination-of-hydrogen-peroxide-and-oxalic-acid
#6
JOURNAL ARTICLE
Yuheng Tao, Yuqi Zhao, Yequan Sheng, Lingyu Ruan, Wenhao Ge, Hongyan Lin, Qing Qing, Yue Zhang, Liqun Wang
Researchers have always been interested in polysaccharide degradation because of the increased biological activity and usability following degradation. In this work, low molecular weight galactomannan (LMW-GM) was produced through the degradation of galactomannan by H2 O2 and oxalic acid (OA). The optimal reaction conditions were found by conducting the response surface optimization experiment based on single-factor experiment and kinetics analysis. Under these conditions, the LMW-GM yield was 69.48 ± 1...
March 11, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38472714/endophytic-bacilli-from-cyamopsis-tetragonoloba-l-taub-induces-plant-growth-and-drought-tolerance
#7
JOURNAL ARTICLE
Vaishali Umrao, Sushma Yadav, Pradeep Semwal, Sankalp Misra, Shashank Kumar Mishra, Puneet Singh Chauhan, Pramod Arvind Shirke
Cyamopsis tetragonoloba (L.) Taub. (guar) is a commercially important crop known for its galactomannan content in seeds. Drought stress is a significant global concern that compromises the productivity of major legumes including guar. The endophytic microbes associated with plants play a significant role in enhancing plant growth and modulating the impact of abiotic stress(s). The present study involved the isolation of 73 endophytic bacteria from the guar seeds of drought-tolerant (RGC-1002 and RGC-1066) and sensitive (Sarada and Varsha) varieties...
March 12, 2024: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://read.qxmd.com/read/38460819/diagnostic-limitations-and-challenges-in-current-clinical-guidelines-and-potential-application-of-metagenomic-sequencing-to-manage-pulmonary-invasive-fungal-infections-in-patients-with-haematological-malignancies
#8
REVIEW
Sarah Y Park, Monica I Ardura, Sean X Zhang
BACKGROUND: Pulmonary invasive fungal infections (pIFI) disproportionately affect patients with haematological malignancies (HM). Establishing a rapid and accurate diagnosis of pIFI is challenging. Multiple guidelines recommend diagnostic testing of invasive fungal infections but lack consensus and may contribute to inconsistent diagnostic approaches. OBJECTIVE: To identify key diagnostic challenges and review metagenomic sequencing data. SOURCES: PubMed, professional consortium, and scientific society websites search to identify relevant, published, evidence-based clinical guidelines within the past five years...
March 7, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38447858/utility-of-galactomannan-diagnostic-assay-in-rhino-orbito-cerebral-mycosis-in-covid-19-patients
#9
JOURNAL ARTICLE
Kuhu Chatterjee, Juhi Taneja, Charu Agarwal, Jaseetha Sasidharan, Asim Das, Aparna Pandey
An increasing number of fungal infections were reported post COVID-19 and many of them were caused by fungi of mixed aetiologies. This study was carried out to assess the utility of serum galactomannan (GM) assay in establishing the etiology of acute rhino-orbito-cerebral mycosis caused by Aspergillusspp. Two serum samples were obtained from 41 suspected post COVID-19 rhino-orbito-cerebral mycosis patients to perform GM assay. Serum GM assay was positive in 68.7% of the cases of proven aspergillosis at cut off OD = 1...
March 4, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38436032/prognostic-factors-and-outcomes-of-invasive-pulmonary-aspergillosis-a-retrospective-hospital-based-study
#10
JOURNAL ARTICLE
Wei-Che Chen, I-Chieh Chen, Jun-Peng Chen, Tsai-Ling Liao, Yi-Ming Chen
OBJECTIVE: Invasive pulmonary aspergillosis (IPA) affects immunocompromised hosts and is associated with higher risks of respiratory failure and mortality. However, the clinical outcomes of different IPA types have not been identified. METHODS: Between September 2002 and May 2021, we retrospectively enrolled patients with IPA in Taichung Veterans General Hospital, Taiwan. Cases were classified as possible IPA, probable IPA, proven IPA, and putative IPA according to EORTC/MSGERC criteria and the AspICU algorithm...
2024: PeerJ
https://read.qxmd.com/read/38435947/adenocarcinoma-of-the-lung-masquerading-as-invasive-pulmonary-aspergillosis-in-an-elderly-lady-a-diagnostic-challenge
#11
Ramyashree N Reddy, Nandakishore Baikunje, Giridhar Belur, Nandu Nair
A 59-year-old hypertensive woman presented with a year-long history of cough, expectoration, and progressive breathlessness, recently complicated by hemoptysis and significant weight loss. Initial investigations, including a chest x-ray and contrast-enhanced computed tomography (CECT) of the thorax, suggested an infective pathology. Despite negative bacterial, fungal, and tuberculosis cultures, elevated bronchoalveolar lavage (BAL) galactomannan and serum Aspergillus-specific IgG levels led to a diagnosis of invasive pulmonary aspergillosis (IPA), and antifungal treatment commenced...
January 2024: Curēus
https://read.qxmd.com/read/38435912/a-case-of-pulmonary-maltoma-camouflaged-within-invasive-pulmonary-aspergillosis
#12
Gurumurthy Thilagavathy, R K Sasankh, Arul Sekary, Niranjan Prabhu Ss
A 59-year-old non-smoking male, with a known case of COPD (chronic obstructive pulmonary disease), treated pulmonary tuberculosis with Category 1 antitubercular drugs (six-month regimen) and was admitted with repeated bouts of moderate haemoptysis (~60 mL/day) for three days. The patient had a history of self-limiting occasional mild haemoptysis (~20 mL) over three years. An HRCT chest revealed a left upper lobe fibro-cavitary lesion with an intracavitary mass (air crescent sign), adjacent pleural thickening and fibrosis...
January 2024: Curēus
https://read.qxmd.com/read/38412026/synthesis-of-galactomannan-fragments-to-help-nmr-assignment-of-polysaccharides-extracted-from-lichens
#13
JOURNAL ARTICLE
Louis-Philippe David, Solenn Ferron, Bénédicte Favreau, Oznur Yeni, Simon Ollivier, David Ropartz, Isabelle Compagnon, Vincent Ferrières, Françoise Le Dévéhat, Laurent Legentil
The synthesis of six model trisaccharides representative of galactomannans produced by lichens was performed through stereoselective glycosylation. These standards include linear and branched galactomannans bearing either galactofuranosyl or galactopyranosyl entities. The complete assignment of 1 H and 13 C signals for both forms of synthetically reduced oligosaccharides was performed. The resulting NMR data were used to quickly demonstrate the structural characteristics of minor polysaccharides within different extracts of three representative lichens...
February 27, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38410274/nutritional-biochemical-and-health-properties-of-locust-beans-and-its-applications-in-the-food-industry-a-review
#14
REVIEW
Kamar Nasrallah, Sanaa Khaled, Sami El Khatib, Maha Krayem
UNLABELLED: The Locust Bean ( Ceratonia siliqua L.) is an ancient Mediterranean fruit that is used to make locust bean gum from seeds, which is a popular ingredient in many foods today. Locust Bean fruit and Gum are rich in bioactive compounds that can be helpful in the treatment of conditions involving the digestive system, as well as cancer, hyperlipidemia, and diabetes. The locust bean gum is a polysaccharide extracted from the endosperm of the locust bean seed through different thermomechanical or chemical processes...
April 2024: Journal of Food Science and Technology
https://read.qxmd.com/read/38409122/biocatalytic-cascade-to-polysaccharide-amination
#15
JOURNAL ARTICLE
Xuebin Feng, Siyi Hong, Hongbo Zhao, Thu V Vuong, Emma R Master
BACKGROUND: Chitin, the main form of aminated polysaccharide in nature, is a biocompatible, polycationic, and antimicrobial biopolymer used extensively in industrial processes. Despite the abundance of chitin, applications thereof are hampered by difficulties in feedstock harvesting and limited structural versatility. To address these problems, we proposed a two-step cascade employing carbohydrate oxidoreductases and amine transaminases for plant polysaccharide aminations via one-pot reactions...
February 27, 2024: Biotechnol Biofuels Bioprod
https://read.qxmd.com/read/38407443/current-perspectives-on-fenugreek-bioactive-compounds-and-their-potential-impact-on-human-health-a-review-of-recent-insights-into-functional-foods-and-other-high-value-applications
#16
REVIEW
Muhammad H Alu'datt, Taha Rababah, Saleh Al-Ali, Carole C Tranchant, Sana Gammoh, Mohammad Alrosan, Stan Kubow, Thuan-Chew Tan, Salsabeel Ghatasheh
Despite long-standing uses in several food and medicine traditions, the full potential of the leguminous crop fenugreek (Trigonella foenum-graecum L.) remains to be realized in the modern diet. Not only its seeds, which are highly prized for their culinary and medicinal properties, but also its leaves and stems abound in phytochemicals with high nutritional and health promoting attributes. Fenugreek dual food-medicine applications and reported metabolic activities include hypoglycemic, antihyperlipidemic, antioxidative, anti-inflammatory, antiatherogenic, antihypertensive, anticarcinogenic, immunomodulatory, and antinociceptive effects, with potential organ-protective effects at the cardiovascular, digestive, hepatic, endocrine, and central nervous system levels...
February 26, 2024: Journal of Food Science
https://read.qxmd.com/read/38403258/time-resolved-fluoroimmunoassay-for-aspergillus-detection-based-on-anti-galactomannan-monoclonal-antibody-from-stable-cell-line
#17
JOURNAL ARTICLE
Wenjun Wang, Chunlong Liu, Xuemei Zhang, Jun Yan, Jiaxing Zhang, Shengping You, Rongxin Su, Wei Qi
Invasive Aspergillosis is a high-risk illness with a high death rate in immunocompromised people due to a lack of early detection and timely treatment. Based on immunology study, we achieved an efficient production of anti-galactomannan antibody by Chinese hamster ovary (CHO) cells and applied it to time-resolved fluoroimmunoassay for Aspergillus galactomannan detection. We first introduced dual promoter expression vector into CHO host cells, and then applied a two-step screening strategy to screen the stable cell line by methionine sulfoximine pressurization...
February 23, 2024: Analytical Biochemistry
https://read.qxmd.com/read/38400525/the-galactose-metabolism-genes-uge1-and-ugm1-are-novel-virulence-factors-of-the-maize-anthracnose-fungus-colletotrichum-graminicola
#18
JOURNAL ARTICLE
Maximilian Groß, Beate Dika, Elisabeth Loos, Lala Aliyeva-Schnorr, Holger B Deising
Fungal cell walls represent the frontline contact with the host and play a prime role in pathogenesis. While the roles of the cell wall polymers like chitin and branched β-glucan are well understood in vegetative and pathogenic development, that of the most prominent galactose-containing polymers galactosaminogalactan and fungal-type galactomannan is unknown in plant pathogenic fungi. Mining the genome of the maize pathogen Colletotrichum graminicola identified the single-copy key galactose metabolism genes UGE1 and UGM1, encoding a UDP-glucose-4-epimerase and UDP-galactopyranose mutase, respectively...
February 23, 2024: Molecular Microbiology
https://read.qxmd.com/read/38391536/the-prognostic-role-of-diagnostic-criteria-for-covid-19-associated-pulmonary-aspergillosis-a-cross-sectional-retrospective-study
#19
JOURNAL ARTICLE
Erika Asperges, Rebecca Pesare, Cecilia Bassoli, Matteo Calia, Sonia Lerta, Francesco Citiolo, Giuseppe Albi, Caterina Cavanna, Paolo Sacchi, Raffaele Bruno
Several criteria exist to diagnose pulmonary aspergillosis with varying degrees of certainty in specific populations, including oncohaematological patients (EORTC/MSG), ICU patients (mAspICU) and COVID-19 patients (ECMM). At the beginning of the pandemic, however, the diagnosis of COVID-19-Associated Pulmonary Aspergillosis (CAPA) could not be performed easily, and the decision to treat (DTT) was empirical. In this cross-sectional retrospective study including patients with SARS-CoV-2 infection and suspicion of CAPA, we studied the concordance between the DTT and the three diagnostic criteria using Cohen's coefficient, and then we identified the factors associated with the DTT and corrected them by treatment to study the influence of the diagnostic criteria on survival...
February 3, 2024: Antibiotics
https://read.qxmd.com/read/38370841/an-observational-cohort-study-of-bronchoalveolar-lavage-fluid-galactomannan-and-aspergillus-culture-positivity-in-patients-requiring-mechanical-ventilation
#20
Catherine A Gao, Nikolay S Markov, Chiagozie Pickens, Anna Pawlowski, Mengjia Kang, James M Walter, Benjamin D Singer, Richard G Wunderink
RATIONALE: Critically ill patients who develop invasive pulmonary aspergillosis (IPA) have high mortality rates despite antifungal therapy. Diagnosis is difficult in these patients. Bronchoalveolar lavage (BAL) fluid galactomannan (GM) is a helpful marker of infection, although the optimal cutoff for IPA is unclear. We aimed to evaluate the BAL fluid GM and fungal culture results, demographics, and outcomes among a large cohort of mechanically ventilated patients with suspected pneumonia...
February 7, 2024: medRxiv
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