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https://www.readbyqxmd.com/read/27919501/soluble-serum-vcam-1-whole-blood-mrna-expression-and-treatment-response-in-natalizumab-treated-multiple-sclerosis
#1
E R Petersen, H B Søndergaard, A B Oturai, Peh Jensen, P S Sorensen, F Sellebjerg, L Börnsen
BACKGROUND: Natalizumab reduces disease activity in multiple sclerosis (MS). Natalizumab binds to the very late antigen-4 and inhibits vascular cell adhesion molecule-1 (VCAM-1)-mediated transmigration of immune cells across the blood-brain-barrier. This is associated with decreased serum concentrations of soluble (s)VCAM-1 and an altered composition of immune cell-subsets in the blood. OBJECTIVE: We aimed to examine if sVCAM-1 serum concentrations and whole blood mRNA expression levels of immune activation biomarkers is associated with disease activity in natalizumab-treated MS-patients...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27881708/il-35-suppresses-lipopolysaccharide-induced-airway-eosinophilia-in-ebi3-deficient-mice
#2
Kyosuke Kanai, Ah-Mee Park, Hiroki Yoshida, Ikuo Tsunoda, Osamu Yoshie
EBI3 functions as the subunit of immune-regulatory cytokines, such as IL-27 and IL-35, by pairing with p28 and p35, respectively. We treated wild-type and EBI3-deficient mice with intratracheal administration of LPS and obtained bronchoalveolar lavage fluid (BALF) 24 h later. Although neutrophils were the predominant cells in BALF from both groups of mice, eosinophils were highly enriched and there was increased production of eosinophil-attracting chemokines CCL11 and CCL24 in BALF of EBI3-deficient mice. The bronchial epithelial cells and alveolar macrophages were the major producers of CCL11 and CCL24...
November 23, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27867385/expanding-diversity-in-molecular-structures-and-functions-of-the-il-6-il-12-heterodimeric-cytokine-family
#3
REVIEW
Hideaki Hasegawa, Izuru Mizoguchi, Yukino Chiba, Mio Ohashi, Mingli Xu, Takayuki Yoshimoto
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they comprise two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. The members of this cytokine family are increasing; currently, there are more than six cytokines, including the tentatively named cytokines IL-Y (p28/p40), IL-12 (p35/p40), IL-23 (p19/p40), IL-27 [p28/Epstein-Barr virus-induced protein 3 (EBI3)], IL-35 (p35/EBI3), and IL-39 (p19/EBI3)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27734415/the-immunobiology-of-interleukin-35-and-its-regulation-and-gene-expression
#4
Mei Song, Xiaojing Ma
Interleukin-35 (IL-35) is the latest addition to the IL-12 family of heterodimeric cytokines, consisting of IL-12 p35 subunit and IL-27β subunit Epstein-Barr virus induced 3 (EBI3). Since its discovery, IL-35 has been shown to exhibit immunosuppressive activities which are distinct from other members of IL-12 family. IL-35 is also unique in that it is expressed primarily by regulatory T-cells (Tregs) rather than by antigen-presenting cells (APCs). IL-35 can directly suppress effector T-cell proliferation and function and inhibit the differentiation of Th17 cells...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27682874/elevated-level-of-interleukin-35-in-colorectal-cancer-induces-conversion-of-t-cells-into-itr35-by-activating-stat1-stat3
#5
Yanhui Ma, Lei Chen, Guohua Xie, Yunlan Zhou, Chaoyan Yue, Xiangliang Yuan, Yingxia Zheng, Weiwei Wang, Lin Deng, Lisong Shen
IL-35 is a novel heterodimeric and inhibitory cytokine, composed of interleukin-12 subunit alpha (P35) and Epstein-Barr virus -induced gene 3 (EBI3). IL-35 has been reported to be produced by a range of cell types, especially regulatory T cells, and to exert immunosuppressive effects via the STATx signaling pathway. In this study, we demonstrated that IL-35 expression was elevated in both serum and tumors in patients with colorectal cancer. IL-35 mainly expressed in CD4+ T cells in human colorectal cancer tumors and adjacent tissues...
September 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27564404/an-il-27-stat3-axis-induces-expression-of-programmed-cell-death-1-ligands-pd-l1-2-on-infiltrating-macrophages-in-lymphoma
#6
Horlad Hasita, Chaoya Ma, Hiromu Yano, Cheng Pan, Koji Ohnishi, Yukio Fujiwara, Shinya Endo, Yoshitaka Kikukawa, Yutaka Okuno, Masao Matsuoka, Motohiro Takeya, Yoshihiro Komohara
Immune escape and tolerance in the tumor microenvironment are closely involved in tumor progression, and are caused by T-cell exhaustion and mediated by the inhibitory signaling of immune checkpoint molecules including programmed death-1 (PD-1), cytotoxic T-lymphocyte associated protein 4, and T-cell immunoglobulin and mucin domain-containing molecule-3. In the present study, we investigated expression of the PD-1 ligand 1 (PD-L1) in a lymphoma microenvironment using paraffin embedded tissue samples, and subsequently studied the detailed mechanism of up-regulation of PD-L1 on macrophages using cultured human macrophages and lymphoma cell lines...
August 26, 2016: Cancer Science
https://www.readbyqxmd.com/read/27500263/kinetics-of-alloantigen-specific-regulatory-cd4-t-cell-development-and-tissue-distribution-after-donor-specific-transfusion-and-costimulatory-blockade
#7
Yusuke Tomita, Miwa Satomi, William Bracamonte-Baran, Ewa Jankowska Gan, Andrea Szymczak Workman, Creg J Workman, Dario Angelo Alberto Vignali, William J Burlingham
BACKGROUND: The influence of donor-side regulation toward recipient antigens on graft outcome is poorly understood. METHODS: Because this influence might be due in part to the accumulation of tissue-resident memory T cells in the donor organ, we used a standard murine tolerization model (donor-specific transfusion plus CD40L blockade) to determine the kinetics of development and peripheralization of allospecific regulatory T cell in lymphoid tissues and liver, a secondary lymphoid organ used in transplantation...
May 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27492538/enhanced-lps-induced-activation-of-il-27-signalling-in-sarcoidosis
#8
Sabine Ringkowski, Joshua Loke, Shuying Huang, Hasib Ahmadzai, Felix J F Herth, Paul S Thomas, Cristan Herbert
RATIONALE: Granulomas in sarcoidosis have recently been described as containing Interleukin (IL)-27, one of the members of the IL-12 family of cytokines, which also includes IL-35. Levels of these cytokines and the IL-27 receptor subunits were hypothesised to differ between patients with sarcoidosis compared to healthy controls in peripheral blood. METHODS: Using a cross-sectional study design, plasma and peripheral blood mononuclear cells (PBMC) were collected from patients and control subjects...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27449853/il-27-a-potential-biomarker-for-responders-to-glatiramer-acetate-therapy
#9
John E Mindur, Reuben M Valenzuela, Sudhir K Yadav, Sridhar Boppana, Suhayl Dhib-Jalbut, Kouichi Ito
Glatiramer acetate (GA) is an FDA-approved efficacious drug for the treatment of relapsing-remitting multiple sclerosis (RRMS). However, this treatment is not effective for all RRMS patients. Therefore, it is important to identify reliable biomarkers that can predict a beneficial clinical response to GA therapy. Since an increase in IL-27 has been demonstrated to suppress autoimmune and allergic diseases of inflammatory origin, we examined the effect of GA on the production of IL-27. We observed that IL-27 production in PBMCs cultured with GA was heterogeneous amongst MS patients and healthy donors (HD), and thus, defined these MS patients as either efficient, weak, or non-IL-27 producers...
July 17, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27400195/interleukin-il-39-il-23p19-epstein-barr-virus-induced-3-ebi3-induces-differentiation-expansion-of-neutrophils-in-lupus-prone-mice
#10
X Wang, X Liu, Y Zhang, Z Wang, G Zhu, G Han, G Chen, C Hou, T Wang, N Ma, B Shen, Y Li, H Xiao, R Wang
Interleukin (IL)-12 family cytokines play critical roles in autoimmune diseases. Our previous study has shown that IL-23p19 and Epstein-Barr virus-induced 3 (Ebi3) form a new IL-12 family heterodimer, IL-23p19/Ebi3, termed IL-39, and knock-down of p19 or Ebi3 reduced diseases by transferred GL7(+) B cells in lupus-prone mice. In the present study, we explore further the possible effect of IL-39 on murine lupus. We found that IL-39 in vitro and in vivo induces differentiation and/or expansion of neutrophils...
November 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27347332/circulating-low-il-23-il-35-cytokine-ratio-promotes-progression-associated-with-poor-prognosisin-breast-cancer
#11
Guanghui Chen, Yanfang Liang, Xin Guan, Hui Chen, Qiankun Liu, Bihua Lin, Can Chen, Mingyuan Huang, Jianan Chen, Weiquan Wu, Yi Liang, Keyuan Zhou, Jincheng Zeng
The interleukin (IL)-12 family, composed of heterodimeric cytokines including IL-12 (formed by IL-12p35 and IL-12p40 subunits), IL-23 (formed by IL-23p19 and IL-12p40 subunits), IL-27 (formed by IL-27p28 and EBI3 subunits) and IL-35 (formed by IL-12p35 and EBI3 subunits), establishes a link between innate and adaptive immunity that involves different immune effector cells and cytokines to tumors. However, the role of IL-12 family in breast cancer (BC) progression and prognosis remains unclear. In the present study, we demonstrated evidence indicating that EBI3, IL-12p35 and IL-12p40 but not IL-23p19 or IL-27p28 were highly expressed in BC tissues, suggested that tumor derived EBI3, IL-12p35 and IL-12p40 were associated with tumor progression...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27247488/epstein-barr-virus-induced-gene-3-ebi3-blocking-leads-to-induce-antitumor-cytotoxic-t-lymphocyte-response-and-suppress-tumor-growth-in-colorectal-cancer-by-bidirectional-reciprocal-regulation-stat3-signaling-pathway
#12
Yanfang Liang, Qianqian Chen, Wenjing Du, Can Chen, Feifei Li, Jingying Yang, Jianyu Peng, Dongping Kang, Bihua Lin, Xingxing Chai, Keyuan Zhou, Jincheng Zeng
Epstein-Barr virus-induced gene 3 (EBI3) is a member of the interleukin-12 (IL-12) family structural subunit and can form a heterodimer with IL-27p28 and IL-12p35 subunit to build IL-27 and IL-35, respectively. However, IL-27 stimulates whereas IL-35 inhibits antitumor T cell responses. To date, little is known about the role of EBI3 in tumor microenvironment. In this study, firstly we assessed EBI3, IL-27p28, IL-12p35, gp130, and p-STAT3 expression with clinicopathological parameters of colorectal cancer (CRC) tissues; then we evaluated the antitumor T cell responses and tumor growth with a EBI3 blocking peptide...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27245409/interleukin-27-il-27-mediates-susceptibility-to-visceral-leishmaniasis-by-suppressing-the-il-17-neutrophil-response
#13
Gustavo F S Quirino, Manuela S L Nascimento, Marcela Davoli-Ferreira, Lais A Sacramento, Mikhael H F Lima, Roque P Almeida, Vanessa Carregaro, João Santana Silva
The relationship established between Leishmania infantum and the vertebrate host can lead to a self-healing infection or to the manifestation of visceral leishmaniasis, a chronic systemic infection associated with high rates of mortality. We hypothesized that regulatory cytokines, such as interleukin-27 (IL-27), play a role in susceptibility to L. infantum infection. IL-27 is a heterodimeric cytokine composed of IL-27p28 and EBi3 subunits which, when combined, bind to IL-27R, leading to STAT-1 and -3 activation, playing a role in the regulation of the immune response...
August 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27158354/elevated-serum-il-35-and-increased-expression-of-il-35-p35-or-ebi3-in-cd4-cd25-t-cells-in-patients-with-active-tuberculosis
#14
Bin Kong, Gan-Bin Liu, Jun-Ai Zhang, Xiao-Xia Fu, Wen-Yu Xiang, Yu-Chi Gao, Yuan-Bin Lu, Xian-Jing Wu, Feng Qiu, Wan-Dang Wang, Lai-Long Yi, Ji-Xin Zhong, Zheng W Chen, Jun-Fa Xu
Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB patients exhibited increases in serum IL-35 and in mRNA expression of both subunits of IL-35 (p35 and EBI3) in white blood cells and peripheral blood mononuclear cells. Consistently, anti-TB drug treatment led to reduction in serum IL-35 level and p35 or EBI3 expression. TB infection was associated with expression of p35 or EBI3 protein in CD4(+) but not CD8(+) T cells...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27118652/-current-research-of-the-roles-of-il-35-in-tumor-progression
#15
Chongbiao Huang, Ye Tian, Yan Cui, Jie Xu, Liang Xin, Xueling Yang, Daliang Qi
Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis...
April 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27019190/a-novel-il-23p19-ebi3-il-39-cytokine-mediates-inflammation-in-lupus-like-mice
#16
Xiaoqian Wang, Yinxiang Wei, He Xiao, Xiaoling Liu, Yu Zhang, Gencheng Han, Guojiang Chen, Chunmei Hou, Ning Ma, Beifen Shen, Yan Li, Charles E Egwuagu, Renxi Wang
Interleukin-12 family cytokines have emerged as critical regulators of immunity with some members (IL-12, IL-23) associated with disease pathogenesis while others (IL-27, IL-35) mitigate autoimmune diseases. Each IL-12 family member is comprised of an α and a β chain, and chain-sharing is a key feature. Although four bona fide members have thus far been described, promiscuous chain-pairing between alpha (IL-23p19, IL-27p28, IL-12/IL-35p35) and beta (IL-12/IL-23p40, IL-27/IL-35Ebi3) subunits, predicts six possible heterodimeric IL-12 family cytokines...
June 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/26905929/protective-role-of-interleukin-27-il-27-gene-polymorphisms-in-patients-with-ulcerative-colitis
#17
Jesús K Yamamoto-Furusho, Rosalinda Posadas-Sánchez, Edith Alvarez-León, Gilberto Vargas-Alarcón
Ulcerative colitis (UC) is a chronic condition of unknown etiology and a polygenic disease. The interleukin 27 (IL-27) have been implicated in the pathogenesis of several autoimmune diseases including inflammatory bowel disease. Several polymorphisms of IL-27 have been associated with several types of cancer and immune disorders. The aim of the present study was to evaluate the association between IL-27 gene polymorphisms and the development of UC. Four polymorphisms of IL-27p28 gene (rs181206, rs26528, rs17855750, and rs40837) and three of the Epstein-Barr virus-induced gene 3 (EBI3) (rs428253, rs4740, and rs4905) were genotyped by 5' exonuclease TaqMan genotyping assays on an ABI Prism 7900HT Fast Real-Time PCR System in 375 Mexican patients with UC and 1599 Mexican Mestizo healthy unrelated individuals...
April 2016: Immunology Letters
https://www.readbyqxmd.com/read/26870212/expression-of-epstein-barr-virus-induced-gene-3-in-cervical-cancer-association-with-clinicopathological-parameters-and-prognosis
#18
Yan-Mei Hou, Juan Dong, Ming-Yuan Liu, Shan Yu
Epstein-Barr virus-induced gene 3 (EBI3) encodes a secretory glycoprotein, and has previously been identified as upregulated in a series of cancers. However, the clinical significance of EBI3 in cervical cancer and the potential of EBI3 as a therapeutic target for this disease have not been elucidated. In the present study, EBI3 expression was analyzed by immunohistochemistry in 90 clinicopathologically characterized cervical cancer tissue samples. The association between EBI3 expression and survival of patients with cervical cancer was also analyzed...
January 2016: Oncology Letters
https://www.readbyqxmd.com/read/26791767/-association-between-single-nucleotide-polymorphisms-of-key-genes-in-t-regulatory-cells-signaling-pathways-and-the-efficacy-of-allergic-rhinitis-immune-therapy
#19
Yu Ruan, Yuan Zhang, Luo Zhang
OBJECTIVE: To investigate the genetic association pattern between single-nucleotide polymorphisms (SNP) of key genes in T regulatory cells signaling pathways and the efficacy of allergic rhinitis (AR) specific immune therapy(SIT). METHODS: A population of 102 AR patients(Beijing Tongren hospital, from January to Decemeber 2012) caused by simple dust mite received standardized specific immune therapy, who lived in Beijing region was recruited. In immunotherapy before and after 1 years of treatment, the study objects were scored by nasal symptoms score, nasal signs score and total score of daily life distress three indicators to assess the efficacy...
January 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/26714886/decidual-vascular-endothelial-cells-promote-maternal-fetal-immune-tolerance-by-inducing-regulatory-t-cells-through-canonical-notch1-signaling
#20
Yanyi Yao, Jieping Song, Weipeng Wang, Nian Liu
Adaptation of the maternal immune response to accommodate the semiallogeneic fetus is necessary for pregnancy success. However, the mechanisms by which the fetus avoids rejection despite expression of paternal alloantigens remain incompletely understood. Regulatory T cells (Treg cells) are pivotal for maintaining immune homeostasis, preventing autoimmune disease and fetus rejection. In this study, we found that maternal decidual vascular endothelial cells (DVECs) sustained Foxp3 expression in resting Treg cells in vitro...
May 2016: Immunology and Cell Biology
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