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https://www.readbyqxmd.com/read/29138852/anti%C3%A2-il%C3%A2-39-il%C3%A2-23p19-ebi3-polyclonal-antibodies-ameliorate-autoimmune-symptoms-in-lupus%C3%A2-like-mice
#1
Xiaoqian Wang, Yu Zhang, Zhiding Wang, Xiaoling Liu, Gaizhi Zhu, Gencheng Han, Guojiang Chen, Chunmei Hou, Tianxiao Wang, Beifen Shen, Yan Li, He Xiao, Ning Ma, Renxi Wang
The interleukin (IL)‑12 family cytokines have been examined as therapeutic targets in the treatment of several autoimmune diseases. Our previous study showed that a novel IL‑12 family cytokine, IL‑39 (IL‑23p19/Ebi3) mediates inflammation in lupus‑like mice. In the present study, the effect of anti‑mouse IL‑39 polyclonal antibodies on autoimmune symptoms in lupus‑like mice was investigated. Rabbit anti‑mouse IL‑39 polyclonal antibodies were produced by immunization with recombinant mouse IL‑39, and purified using protein A chromatography...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29118754/critical-role-of-plasmacytoid-dendritic-cells-in-regulating-gene-expression-and-innate-immune-responses-to-human-rhinovirus-16
#2
Yang Xi, Niamh M Troy, Denise Anderson, Olga M Pena, Jason P Lynch, Simon Phipps, Anthony Bosco, John W Upham
Though human rhinoviruses (HRVs) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of impaired interferon (IFN) synthesis. Plasmacytoid dendritic cells (pDCs) are key IFN producing cells, though we know little about the role of pDC in HRV-induced immune responses. Herein, we used gene expression microarrays to examine HRV-activated peripheral blood mononuclear cells (PBMCs) from healthy people, in combination with pDC depletion, to assess whether observed gene expression patterns were pDC dependent...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29057512/induction-of-porcine-specific-regulatory-t-cells-with-high-specificity-and-expression-of-il-10-and-tgf-%C3%AE-1-using-baboon-derived-tolerogenic-dendritic-cells
#3
Mingqian Li, Judith Eckl, Jan-Michael Abicht, Tanja Mayr, Bruno Reichart, Dolores J Schendel, Heike Pohla
BACKGROUND: Regulatory T cells (Treg) play an important role in maintenance of homeostasis in vivo. Treg application to alleviate allo-organ rejection is being studied extensively. However, natural Treg (nTreg) expansion in vitro is laborious and expensive. Antigen-specific Treg are more effective and require lower cell numbers than use of nTreg for immune control. The baboon, as a non-human primate experimental animal model, is widely used in xenotransplantation research. An effective method to generate baboon xeno-specific Treg would benefit research on immune tolerance in xenotransplantation using this model system...
October 22, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/29033934/ebi3-prevents-trypanosoma-cruzi-induced-myocarditis-by-dampening-ifn-%C3%AE-driven-inflammation
#4
Tiago Silva Medina, Gabriela Gonçalves Oliveira, Maria Cláudia Silva, Bruna Araújo David, Grace Kelly Silva, Denise Morais Fonseca, Renata Sesti-Costa, Amanda Farage Frade, Monique Andrade Baron, Barbara Ianni, Alexandre Costa Pereira, Christophe Chevillard, Edécio Cunha-Neto, José Antonio Marin-Neto, João Santana Silva
The identification of anti-inflammatory mediators can reveal important targetable molecules capable of counterbalancing Trypanosoma cruzi-induced myocarditis. Composed of Ebi3 and IL-27p28 subunits, IL-27 is produced by myeloid cells and is able to suppress inflammation by inducing IL-10-producing Tr1 cells, thus emerging as a potential candidate to ameliorate cardiac inflammation induced by T. cruzi. Although IL-27 has been extensively characterized as a suppressive cytokine that prevents liver immunopathogenesis after T...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28989066/interleukin-35-expression-correlates-with-microvessel-density-in-pancreatic-ductal-adenocarcinoma-recruits-monocytes-and-promotes-growth-and-angiogenesis-of-xenograft-tumors-in-mice
#5
Chongbiao Huang, Zengxun Li, Na Li, Yang Li, Antao Chang, Tiansuo Zhao, Xiuchao Wang, Hongwei Wang, Song Gao, Shengyu Yang, Jihui Hao, He Ren
BACKGROUND & AIMS: Cells of the monocyte lineage contribute to tumor angiogenesis. Interleukin 35 (IL35) is a member of the IL12 family produced by regulatory, but not effector, T cells. IL35 is a dimer comprising the IL12 alpha and IL27 beta chains, encoded by IL12A and EBI3, respectively. Expression of IL35 is increased in pancreatic ductal adenocarcinomas (PDACs) compared with normal pancreatic tissues, and promotes metastasis. We investigated the role of IL-35 in monocyte-induced angiogenesis of PDAC in mice...
October 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28959012/il-12p35-induces-expansion-of-il-10-and-il-35-expressing-regulatory-b-cells-and-ameliorates-autoimmune-disease
#6
Ivy M Dambuza, Chang He, Jin Kyeong Choi, Cheng-Rong Yu, Renxi Wang, Mary J Mattapallil, Paul T Wingfield, Rachel R Caspi, Charles E Egwuagu
Interleukin 35 (IL-35) is a heterodimeric cytokine composed of IL-12p35 and Ebi3 subunits. IL-35 suppresses autoimmune diseases while preventing host defense to infection and promoting tumor growth and metastasis by converting resting B and T cells into IL-10-producing and IL-35-producing regulatory B (Breg) and T (Treg) cells. Despite sharing the IL-12p35 subunit, IL-12 (IL-12p35/IL-12p40) promotes inflammatory responses whereas IL-35 (IL-12p35/Ebi3) induces regulatory responses, suggesting that IL-12p35 may have unknown intrinsic immune-regulatory functions regulated by its heterodimeric partner...
September 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/28852164/genome-wide-dna-methylation-and-transcriptome-analyses-reveal-genes-involved-in-immune-responses-of-pig-peripheral-blood-mononuclear-cells-to-poly-i-c
#7
Haifei Wang, Jiying Wang, Chao Ning, Xianrui Zheng, Jinlian Fu, Aiguo Wang, Qin Zhang, Jian-Feng Liu
DNA methylation changes play essential roles in regulating the activities of genes involved in immune responses. Understanding of variable DNA methylation linked to immune responses may contribute to identifying biologically promising epigenetic markers for pathogenesis of diseases. Here, we generated genome-wide DNA methylation and transcriptomic profiles of six pairs of polyinosinic-polycytidylic acid-treated pig peripheral blood mononuclear cell (PBMC) samples and corresponding controls using methylated DNA immunoprecipitation sequencing and RNA sequencing...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819340/corrigendum-to-epstein-barr-virus-induced-gene-3-ebi3-blocking-leads-to-induce-antitumor-cytotoxic-t-lymphocyte-response-and-suppress-tumor-growth-in-colorectal-cancer-by-bidirectional-reciprocal-regulation-stat3-signaling-pathway
#8
Yanfang Liang, Qianqian Chen, Wenjing Du, Can Chen, Feifei Li, Jingying Yang, Jianyu Peng, Dongping Kang, Bihua Lin, Xingxing Chai, Keyuan Zhou, Jincheng Zeng
[This corrects the article DOI: 10.1155/2016/3214105.].
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28791821/il-22-modulates-inflammatory-properties-of-human-primary-aortic-smooth-muscle-cells
#9
Paulina Gorzelak-Pabis, Maciej Chałubiński, Katarzyna Wojdan, Emilia Łuczak, Maciej Borowiec, Marlena Broncel
BACKGROUND: IL-22 is expressed at barrier surfaces, which suggests its critical role in the maintenance of normal barrier homeostasis and tissue repair. IL-22 can both promote pathological inflammation and prevent the destruction of tissues. The functional outcomes of IL-22 on vascular smooth muscle cells, which are shown to regulate immune processes within the vascular wall and which are involved in certain pathologies, have not been analyzed. OBJECTIVES: The effect of IL-22 on the expression of novel antiand pro-inflammatory and barrier disrupting cytokines, apoptosis and the expression of adhesive molecules in human primary aortic smooth muscle cells (AoSMC) was investigated...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28758191/interleukin-27-signalling-induces-stem-cell-antigen-1-expression-in-t-lymphocytes-in%C3%A2-vivo
#10
Zhihao Liu, Lisha Wu, Jing Zhu, Xiaotong Zhu, Jianmin Zhu, Jin-Qing Liu, Jianchao Zhang, Jonathan P Davis, Sanjay Varikuti, Abhay R Satoskar, Jie Zhou, Ming-Song Li, Xue-Feng Bai
Stem cell antigen-1 (Sca-1/Ly6A/E) is a cell surface glycoprotein that is often used as a biomarker for stem cells and cell stemness. However, it is not clear what factors can directly induce the expression of Sca-1/Ly6A/E in T lymphocytes in vivo, and if induction of Sca-1 is associated with T cell stemness. In this study, we show that interleukin-27 (IL-27), a member of the IL-12 family of cytokines, directly induces Sca-1 expression in T cells in vivo. We found that mice-deficient for IL-27 (either P28 or EBI3) or its signalling (IL-27Rα) had profound reduction of Sca-1 expression in naive (CD62L(+)  CD44(-) ), memory (CD62L(+)  CD44(+) ) and effector (CD62L(-)  CD44(+) ) T cells...
December 2017: Immunology
https://www.readbyqxmd.com/read/28713164/human-immunodeficiency-virus-type-1-induces-a-regulatory-b-cell-like-phenotype-in-vitro
#11
Jacobo Lopez-Abente, Adrián Prieto-Sanchez, Maria-Ángeles Muñoz-Fernandez, Rafael Correa-Rocha, Marjorie Pion
Individuals infected with human immunodeficiency virus type-1 (HIV-1) usually show a general dysregulation and hyper-activation of the immune system. A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously described. However, the consequences of B-cell dysregulation are still poorly understood. We evaluated the phenotypic changes in primary B cells after direct contact with HIV-1 particles in comparison with different types of stimuli. The functionality of treated B cells was challenged in co-culture experiments with autologous CD4+ and CD8+ T cells...
July 17, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28680336/significant-reduction-of-peripheral-blood-interleukin-35-and-cd4-ebi3-t-cells-which-are-negatively-correlated-with-an-increase-in-the-plasma-il-17-and-ctni-level-in-viral-myocarditis-patients
#12
Han Ouyang, Li Xiang, Jianchang Chen, Weiting Xu, Yang Jiao, Huaying Shen
INTRODUCTION: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4(+)EBI3(+) T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease. MATERIAL AND METHODS: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4(+)EBI3(+) T cells in 40 VMC patients and in 20 healthy individuals...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28659009/upregulation-of-interleukin-35-in-patients-with-endometriosis-stimulates-cell-proliferation
#13
Chun Zhang, Zheng Peng, DeYing Ban, Yi Zhang
In this study, we investigated the expression of interleukin 35 (IL-35) and its receptors in endometriosis, analyzed the function of IL-35 in primary culture model of endometrial stromal cells (ESCs), and evaluated their clinicapathological significance. Peripheral blood (PB) and peritoneal fluid (PF) were collected from 37 women with endometriosis and 24 control women. The ectopic endometrium was obtained from patients with endometriosis undergoing laparoscopic surgery. The eutopic and normal endometrium were collected by endometrial biopsy...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28553015/interluekin-35-in-asthma-and-its-potential-as-an-effective-therapeutic-agent
#14
REVIEW
Peng Gao, Zhenzhong Su, Xuejiao Lv, Jie Zhang
Interleukin- (IL-) 35 is a member of the IL-12 cytokine family and a heterodimeric protein formed by Epstein-Barr-induced gene 3 (EBI3) and IL-12p35. Emerging evidence shows that IL-35 is a key player in the regulation of cellular communication, differentiation, and inflammation. Altered IL-35 expression has been found in disease conditions such as cancer, rheumatoid arthritis, and, more recently, asthma. In cancer, IL-35 is involved in the regulation of tumorigenesis, cancer progression, and metastasis. In rheumatoid arthritis, IL-35 acts as a negative regulator of inflammation...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28506283/prolactin-blocks-the-expression-of-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-and-reduces-osteoclastogenesis-and-bone-loss-in-murine-inflammatory-arthritis
#15
Maria G Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp
BACKGROUND: Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone loss in AIA and in monoarticular AIA (MAIA). METHODS: Joint inflammation, trabecular bone loss, and osteoclastogenesis were evaluated in rats with AIA treated with PRL (via osmotic minipumps) and in mice with MAIA that were null (Prlr-/-) or not (Prlr+/+) for the PRL receptor...
May 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28362822/fasciola-hepatica-reinfection-potentiates-a-mixed-th1-th2-th17-treg-response-and-correlates-with-the-clinical-phenotypes-of-anemia
#16
M Adela Valero, Ignacio Perez-Crespo, Carlos Chillón-Marinas, Messaoud Khoubbane, Carla Quesada, Marta Reguera-Gomez, Santiago Mas-Coma, Manuel Fresno, Núria Gironès
BACKGROUND: Fascioliasis is a severe zoonotic disease of worldwide extension caused by liver flukes. In human fascioliasis hyperendemic areas, reinfection and chronicity are the norm and anemia is the main sign. Herein, the profile of the Th1/Th2/Th17/Treg expression levels is analyzed after reinfection, correlating them with their corresponding hematological biomarkers of morbidity. METHODOLOGY/PRINCIPAL FINDINGS: The experimental design reproduces the usual reinfection/chronicity conditions in human fascioliasis endemic areas and included Fasciola hepatica primo-infected Wistar rats (PI) and rats reinfected at 8 weeks (R8), and at 12 weeks (R12), and negative control rats...
2017: PloS One
https://www.readbyqxmd.com/read/28351328/effect-of-ebi3-on-radiation-induced-immunosuppression-of-cervical-cancer-hela-cells-by-regulating-treg-cells-through-pd-1-pd-l1-pathway
#17
Song-An Zhang, Hu-Er-Xi-Dan Niyazi, Wen Hong, Gu-Li-Xian Tuluwengjiang, Lei Zhang, Yang Zhang, Wei-Peng Su, Yong-Xing Bao
This study aimed to investigate the effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 signaling pathway. A total of 43 adult female Wistar rats were selected and injected with HeLa cells in the caudal vein to construct a rat model of cervical cancer. All model rats were randomly divided into the radiotherapy group ( n = 31) and the control group ( n = 12). The immunophenotype of Treg cells was detected by the flow cytometry...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28321150/interleukin-35-polymorphisms-are-associated-with-decreased-risk-of-premature-coronary-artery-disease-metabolic-parameters-and-il-35-levels-the-genetics-of-atherosclerotic-disease-gea-study
#18
Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Javier Angeles-Martínez, Fabiola López-Bautista, Teresa Villarreal-Molina, José Manuel Rodríguez-Pérez, José Manuel Fragoso, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals. The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls. Under different models, the EBI3 rs428253 (OR = 0.831, Padd = 0.036; OR = 0.614, Prec = 0...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28255204/dual-roles-of-il-27-in-cancer-biology-and-immunotherapy
#19
REVIEW
Marina Fabbi, Grazia Carbotti, Silvano Ferrini
IL-27 is a pleiotropic two-chain cytokine, composed of EBI3 and IL-27p28 subunits, which is structurally related to both IL-12 and IL-6 cytokine families. IL-27 acts through a heterodimer receptor consisting of IL-27Rα (WSX1) and gp130 chains, which mediate signaling predominantly through STAT1 and STAT3. IL-27 was initially reported as an immune-enhancing cytokine that supports CD4(+) T cell proliferation, T helper (Th)1 cell differentiation, and IFN-γ production, acting in concert with IL-12. However, subsequent studies demonstrated that IL-27 displays complex immune-regulatory functions, which may result in either proinflammatory or anti-inflammatory effects in relationship to the biological context and experimental models considered...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28143936/ebi3-regulates-the-nk-cell-response-to-mouse-cytomegalovirus-infection
#20
Helle Jensen, Shih-Yu Chen, Lasse Folkersen, Garry P Nolan, Lewis L Lanier
Natural killer (NK) cells are key mediators in the control of cytomegalovirus infection. Here, we show that Epstein-Barr virus-induced 3 (EBI3) is expressed by human NK cells after NKG2D or IL-12 plus IL-18 stimulation and by mouse NK cells during mouse cytomegalovirus (MCMV) infection. The induction of EBI3 protein expression in mouse NK cells is a late activation event. Thus, early activation events of NK cells, such as IFNγ production and CD69 expression, were not affected in EBI3-deficient (Ebi3(-/-) ) C57BL/6 (B6) mice during MCMV infection...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
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