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https://www.readbyqxmd.com/read/28912993/bilateral-peritonsillar-abscess-in-an-infant-an-unusual-presentation-of-sore-throat
#1
Mariana Manzoni Seerig, Letícia Chueiri, Janaina Jacques, Maria Fernanda Piccoli Cardoso de Mello, Martin Batista Coutinho da Silva, Daniel Buffon Zatt, Rosana Cristine Otero Cunha, Andre Souza de Albuquerque Maranhão
INTRODUCTION: Peritonsillar abscess is considered a suppurative complication of acute tonsillitis. It is usually unilateral and clinically evident bilateral presentation is uncommon. The condition affects mainly children older than 10 years and young adults. Herein we present a rare case of bilateral peritonsillar abscess in an infant. PRESENTATION OF CASE: A 1-year-old boy presented with a two-day history of worsening sore throat, loss of appetite, vomiting, and fever...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28903335/sodium-selenite-prevents-suppression-of-mucosal-humoral-response-by-afb1-in-broiler-s-cecal-tonsil
#2
Chunyu Liu, Zhicai Zuo, Panpan Zhu, Zhixiang Zheng, Xi Peng, Jing Fang, Hengmin Cui, Yi Zhou, Ping Ouyang, Yi Geng, Junliang Deng, Yu Sun
Aflatoxin B1 (AFB1), the most common mycotoxin in human food and animal feed, produces hepatotoxic, genotoxic and immunosuppressive effects in multiple species. Selenium (Se) has emerged as an important element in the dietary prevention of various toxic agents. The present study was designed to scrutinize the protective effects of sodium selenite on the histological lesions and suppression of mucosal humoral response in the cecal tonsil generated by AFB1. A total of 156 one-day-old broilers were divided into four groups and fed on basal diet (control group), 0...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900734/the-presence-of-minor-salivary-glands-in-the-peritonsillar-space
#3
Enni Kaltiainen, Johanna Wikstén, Leena-Maija Aaltonen, Taru Ilmarinen, Jaana Hagström, Karin Blomgren
Peritonsillar abscess (PTA) is traditionally considered only a purulent complication of acute tonsillitis (AT), but may be related to infection of minor salivary glands. We analysed the presence of peritonsillar minor salivary glands and inflammation patterns in 114 adult tonsils representing three patient groups: recurrent AT, chronic tonsillitis (CT), and PTA. Samples acquired from elective tonsillectomies were stored in formalin, and after preparation were microscopically examined for inflammation and fibrotic changes...
September 12, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28899547/linear-dimensions-of-normal-upper-airway-structure-by-magnetic-resonance-imaging-in-chinese-han-infants-and-preschool-children
#4
Xiaoli Yi, Linyin Yao, Xinyu Yuan, Yongxiang Wei, Zhenchang Wang
OBJECTIVES: To establish normative data of upper airway structure in Chinese Han infants and preschool children. METHODS: Magnetic resonance imaging (MRI) scans of 521 Chinese Han infants and preschool children (225 girls, 296 boys) aged from 1 day to 72 months were selected from the children who underwent head MRI at the Capital Institute of Pediatrics Affiliated Children Hospital, Beijing, China. No subjects had sleep-disordered breathing or associated conditions that may have affected the upper airway anatomy...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28895406/identification-of-potential-key-genes-associated-with-diffuse-large-b-cell-lymphoma-based-on-microarray-gene-expression-profiling
#5
X Luo, F Shi, H Qiu, Y Tong, X Gao
The study aimed to screen potential key genes, and their targeted miRNAs and transcription factors (TFs) that were related to diffuse large B-cell lymphoma (DLBCL), and explore potential therapeutic targets for the progression of DLBCL. Dataset GSE56315 extracted from human tonsils was downloaded from Gene Expression Omnibus. Limma package was used to identify differential expression genes (DEG) between DLBCL and normal human tonsils samples, and the function and pathway enrichment analyses were performed. Then, functional interaction (FI) networks analyses of DEGs were implemented, and modules were extracted...
September 12, 2017: Neoplasma
https://www.readbyqxmd.com/read/28894116/characterization-of-tonsillar-il10-secreting-b-cells-and-their-role-in-the-pathophysiology-of-tonsillar-hypertrophy
#6
Lindybeth Sarmiento Varon, Javier De Rosa, Andrés Machicote, Luis Ariel Billordo, Plácida Baz, Pablo Mariano Fernández, Isabel Kaimen Maciel, Andrés Blanco, Eloísa I Arana
The comprehension of unconventional immune functions of tonsillar B cells, their role in tolerance induction and protective immune responses, is crucial to unveil the dynamic interactions of the upper aero digestive tract with polymicrobial commensal flora and pathogens, in health and disease. Here, we describe the kinetics of IL10 intracellular expression and compare it with that of cytokines known to be produced by tonsillar B cells. Additionally, we detected a relevant proportion of IL17-expressing tonsillar B cells, which has not previously been reported...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891195/prevalence-of-synchronous-bilateral-tonsil-squamous-cell-carcinoma-a-retrospective-study
#7
Malene Sine Rokkjaer, Tejs Ehlers Klug
OBJECTIVES: The prevalence of synchronous bilateral tonsil cancer remains unexplored. To date, only 38 cases have been described in the literature. With an aim to substantiate the Danish recommendation of performing bilateral tonsillectomy in patients with suspected or proven tonsil cancer and in patients with cervical carcinoma metastasis from an unknown primary tumour, the current study was undertaken to determine the prevalence of synchronous bilateral tonsil cancer. DESIGN: A retrospective review of all patients diagnosed with tonsil cancer in the period 2000-2015, Aarhus University Hospital, Denmark, was performed...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28888637/high-abundance-and-diversity-of-extended-spectrum-beta-lactamase-esbl-producing-escherichia-coli-in-faeces-and-tonsils-of-pigs-at-slaughter
#8
I Van Damme, C Garcia-Graells, W Biasino, T Gowda, N Botteldoorn, L De Zutter
This cross-sectional study investigates the abundance of cefotaxime-resistant Escherichia coli (CREC) in the faeces and tonsils of 96 pigs during slaughter. Moreover, different isolates from a selected number of pigs were tested to study the diversity of blaESBL genes within E. coli isolates from one pig. Cefotaxime-resistant bacteria (based on enumeration results on MacConkey agar supplemented with 1mg/L cefotaxime) were found in the faeces of 77 pigs (80%; 95% CI: 70-87%) and the tonsils of 91 pigs (95%; 95% CI: 88%-98%)...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28887707/correlations-between-patient-reported-dysphagia-screening-and-penetration-aspiration-scores-in-head-and-neck-cancer-patients-post-oncological-treatment
#9
Johanna Hedström, Lisa Tuomi, Caterina Finizia, Caroline Olsson
Dysphagia is a common and severe toxicity after oncological treatment of head and neck cancer (HNC). The study aim was to investigate relationships between patient-reported dysphagia and clinically measured swallowing function in HNC after modern curative radiotherapy with or without chemotherapy to identify possible alarm symptoms for clinically manifest dysphagia. Patients with tumors of the tonsil, base of tongue, hypopharynx, and larynx treated in 2007-2015 were assessed for dysphagia post-treatment by telephone interview and videofluoroscopy (VFS)...
September 8, 2017: Dysphagia
https://www.readbyqxmd.com/read/28885784/changes-in-tonsil-b-cell-phenotypes-and-ebv-receptor-expression-in-children-under-5-years-old
#10
Eric M Wohlford, Paul C Baresel, Joel R Wilmore, Anthony J Mortelliti, Carrie B Coleman, Rosemary Rochford
BACKGROUND: Palatine tonsils are principally B cell organs that are the initial line of defense against many oral pathogens, as well as the site of infection for others. While the size of palatine tonsils changes greatly in the first five years of life, the cellular changes during this period are not well studied. Epstein Barr virus (EBV) is a common orally transmitted virus that infects tonsillar B cells. Naïve B cells are thought to be the target of primary infection with EBV in vivo, suggesting that they are targeted by the virus...
September 8, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28885352/successful-5-azacytidine-treatment-of-myeloid-sarcoma-and-leukemia-cutis-associated-with-myelodysplastic-syndrome-a-case-report-and-literature-review
#11
REVIEW
Takayuki Katagiri, Takashi Ushiki, Masayoshi Masuko, Tomoyuki Tanaka, Shukuko Miyakoshi, Kyoko Fuse, Yasuhiko Shibasaki, Jun Takizawa, Sadao Aoki, Hirohito Sone
RATIONALE: Myeloid sarcoma (MS) and leukemia cutis (LC) are extramedullary tumors comprising myeloid blasts. They can occur de novo or concurrently with hematological disorders, usually acute myeloid leukemia (AML). AML chemotherapy is generally the initial therapy for MS and LC, and hematopoietic stem cell transplantation (HSCT) can be considered as additional therapy. However, treatment for older patients who are unable to continue intensive chemotherapy is not currently standardized...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28885133/the-addition-of-duraplasty-to-posterior-fossa-decompression-in-the-surgical-treatment-of-pediatric-chiari-malformation-type-i-a-systematic-review-and-meta-analysis-of-surgical-and-performance-outcomes
#12
Victor M Lu, Kevin Phan, Sean P Crowley, David J Daniels
OBJECTIVE Surgery is the definitive treatment of Chiari malformation Type I (CM-I). It involves posterior fossa decompression, which can be performed along with C-1 laminectomy, reconstructive duraplasty, or tonsil shrinkage. The aim of this study was to provide an updated systematic review and meta-analysis of the latest available evidence regarding posterior fossa decompression only (PFDO) versus posterior fossa decompression with duraplasty (PFDD) in the treatment of CM-I in children. METHODS A literature search was performed in compliance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for article identification, screening, eligibility, and inclusion...
September 8, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28882851/managing-scarlet-fever
#13
(no author information available yet)
Scarlet fever, an infection caused by toxin-producing strains of Streptococcus pyogenes, was associated with high levels of morbidity and mortality when epidemics were common in the 18(th) and 19(th) centuries throughout Europe and the USA.(1) Although this disease nearly disappeared during the 20(th) century, several countries, including the UK, have recently experienced a re-emergence of scarlet fever.(1-3) However, the reason for these new outbreaks remains unclear.(1,4) Despite a general move to reduce the use of antibiotics for many mild self-limiting infections (e...
September 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28882091/measles-lymphadenopathy-in-a-child-with-pfapa-syndrome
#14
Jefferson Terry, Kelly Brown, Joanne Hiebert, Ghada N Al-Rawahi, J Paul Moxham, Mel Krajden, Agatha N Jassem, Lori Tucker
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a common cause of periodic fever in children. The pathogenesis of PFAPA is unknown but likely involves immune system dysregulation and may be initiated by an environmental trigger. Tonsillectomy resolves or improves symptoms in some patients, but the reason for this is unknown; moreover, specific abnormalities in tonsillectomy specimens from PFAPA patients have not been described. Here, we report measles virus in tonsil from a child with PFAPA...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28881665/hpv-associated-differential-regulation-of-tumor-metabolism-in-oropharyngeal-head-and-neck-cancer
#15
Young-Suk Jung, Abdo J Najy, Wei Huang, Seema Sethi, Michael Snyder, Wael Sakr, Gregory Dyson, Maik Hüttemann, Icksoo Lee, Rouba Ali-Fehmi, Silvia Franceschi, Linda Struijk, Harold E Kim, Ikuko Kato, Hyeong-Reh Choi Kim
HPV-positive oropharyngeal cancer patients experience significantly lower locoregional recurrence and higher overall survival in comparison with HPV-negative patients, especially among those who received radiation therapy. The goal of the present study is to investigate the molecular mechanisms underlying the differential radiation sensitivity between HPV-negative and HPV-positive head and neck squamous cell carcinoma (HNSCC). Here, we show that HPV-negative HNSCC cells exhibit increased glucose metabolism as evidenced by increased production of lactate, while HPV-positive HNSCC cells effectively utilize mitochondrial respiration as evidenced by increased oxygen consumption...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881377/comparison-of-unilateral-versus-bilateral-intensity-modulated-radiotherapy-for-surgically-treated-squamous-cell-carcinoma-of-the-palatine-tonsil
#16
Re-I Chin, Yuan James Rao, Michael Y Hwang, Christopher R Spencer, Michael Pierro, Todd DeWees, Pranav Patel, Parul Sinha, Hiram A Gay, Mackenzie Daly, Bruce H Haughey, Brian Nussenbaum, Douglas R Adkins, James S Lewis, Wade L Thorstad
BACKGROUND: The authors hypothesized that unilateral intensity-modulated radiotherapy (IMRT) would decrease toxicity compared with bilateral IMRT for patients with lateralized palatine tonsillar cancer and a neck classification of N0 to N2b, with similar oncological outcomes. METHODS: A total of 154 patients were treated with postoperative IMRT from 1997 through 2013. Data were collected prospectively from 2005 to 2013 and retrospectively collected before 2005. Of those patients with lateralized primary and N0 to N2b disease, 48 received unilateral IMRT (group 1) and 59 received bilateral IMRT (group 2); a total of 47 patients had nonlateralized primary or N2c to N3 disease and received bilateral IMRT (group 3)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28877610/the-tumor-suppressive-role-of-inhibin-%C3%AE-a-in-diffuse-large-b-cell-lymphoma
#17
Lei Jiang, Ting Si, Mei Yu, Xinli Zeng, Herbert C Morse, Ying Lu, Guifang Ouyang, Jeff X Zhou
INHBA (inhibin βA), a subunit of a ligand of the transforming growth factor-β superfamily, is known to play diverse roles in various solid tumors. However, its role in hematologic malignancies remains unexplored. Here, we investigated the function of INHBA in diffuse large B-cell lymphoma (DLBCL). Both mRNA and protein levels of INHBA were significantly downregulated in primary DLBCL tissues, irrespective of germinal center B-cell-like (GCB) or non-GCB subtype, compared to those in benign tonsils. The low level of INHBA in patients with de novo DLBCL was correlated with reduced overall and progression-free survival...
September 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28877566/is-ginger-effective-in-reducing-post-tonsillectomy-morbidity-a-prospective-randomised-clinical-trial
#18
İlker Koçak, Cemil Yücepur, Ozan Gökler
Objectives: An assessment of the effects of ginger on pain, nausea, vomiting, bleeding, and wound site healing that occur after tonsillectomy. Methods: This prospective clinical study was participated by 49 patients aged 18-45 years out of 56 patients that underwent tonsillectomy and regularly attended follow-up visits. The patients were randomly divided into two groups. Group 1 consisted of 23 patients that used ginger capsules and group 2 consisted of 26 patients that did not use ginger capsules in addition to the routine antibiotic and paracetamol treatment following tonsillectomy...
September 8, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28877231/functional-characterization-of-t-cells-from-palatine-tonsils-in-patients-with-chronic-tonsillitis
#19
Katharina Geißler, Robby Markwart, Robert Pascal Requardt, Cynthia Weigel, Katja Schubert, André Scherag, Ignacio Rubio, Orlando Guntinas-Lichius
The palatine tonsils, localized in the oropharynx, are easily accessible secondary lymphoid tissue in humans. Inflammation of the palatine tonsils, local and chronic in case of chronic tonsillitis (CT) or acute in the presence of a peritonsillar abscess (PTA), ranks among the most common diseases in otolaryngology. However, the functionality of tonsillar immune cells, notably T-cells, in the context of these immune pathologies is poorly understood. We have examined the functional status of human tonsillar T-cells in CT and compared it to the acute inflammatory setting of a PTA...
2017: PloS One
https://www.readbyqxmd.com/read/28871840/lingual-tonsillectomy-for-pediatric-persistent-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#20
Alexander Rivero, Megan Durr
Objective To determine the role of lingual tonsillectomy (LT) in pediatric patients with persistent obstructive sleep apnea (OSA) after tonsillectomy and adenoidectomy (T&A). Data Sources PubMed, OVID-MEDLINE, and Cochrane Central from 2006 to 2017. Review Methods Inclusion criteria included English-language studies containing original data on LT in pediatric patients with persistent OSA. Exclusion criteria included case reports and studies without outcome measures. Two investigators independently reviewed all manuscripts and performed quality assessment using validated tools...
September 1, 2017: Otolaryngology—Head and Neck Surgery
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