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https://www.readbyqxmd.com/read/28092816/encapsulation-of-cisplatin-in-a-pegylated-calcium-phosphate-nanoparticle-cpnp-for-enhanced-cytotoxicity-to-cancerous-cells
#1
Yang Ding, Kang Zhai, Pei Pei, Yue Lin, Yinchu Ma, Huixia Zhu, Mingfeng Shao, Xianzhu Yang, Wei Tao
HYPOTHESIS: Exchange of the chloride ion (Cl(-)) ligands of cisplatin with carboxylates is widely used in fabricating cisplatin loaded nanoparticles for improved cancer therapy. However, the dynamic exchange may cause premature cisplatin release and even disintegration of the nanoparticles in Cl(-)-containing medium such as in plasma. Molecules bearing carboxylates are capable of mediating the mineralization process of calcium phosphate; therefore, it is possible to overcome the disadvantage by sequestering cisplatin in a calcium phosphate nanoparticle (CPNP)...
January 11, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28092292/epicardial-collaterals-spasm-as-a-cause-of-st-elevation-myocardial-infarction
#2
Vincenzo Vetrugno, Francesco Fracassi, Osama Shoeib, Domenico D'Amario, Giampaolo Niccoli, Filippo Crea
ST elevation myocardial infarction in a 61-year-old man with a history of previous coronary artery bypass grafts. Spasm of collaterals to the circumflex coronary artery was the cause of acute presentation and was successfully treated by intracoronary nitrates. Chronic therapy with calcium channel blockers was added in the discharge medications chart.
January 13, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28090634/dietary-interventions-for-fetal-growth-restriction-therapeutic-potential-of-dietary-nitrate-supplementation-in-pregnancy
#3
Elizabeth Cottrell, Teresa Tropea, Laura Ormesher, Susan Greenwood, Mark Wareing, Edward Johnstone, Jenny Myers, Colin Sibley
Fetal growth restriction (FGR) affects around 5% of pregnancies and is associated with significant short- and long-term adverse outcomes. A number of factors can increase the risk of FGR, one of which is poor maternal diet. In terms of pathology, both clinically and in many experimental models of FGR, impaired uteroplacental vascular function is implicated, leading to a reduction in the delivery of oxygen and nutrients to the developing fetus. Whilst mechanisms underpinning impaired uteroplacental vascular function are not fully understood, interventions aimed at enhancing nitric oxide (NO) bioavailability remain a key area of interest in obstetric research...
January 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28089275/microfluidic-membrane-suppressor-module-design-and-evaluation-for-capillary-ion-chromatography
#4
Sam Wouters, Cees Bruggink, Yury Agroskin, Christopher Pohl, Sebastiaan Eeltink
A microfluidic ion-suppression module for use in ion-exchange chromatography has been developed and evaluated. The device consists of an ion-exchange membrane clamped between two polymer chips featuring a 200×100μm (width×depth) eluent channel (l=60mm), and a 300×150μm regenerant channel (60mm), respectively. The suppression efficacy using a Nafion membrane was compared with that of a styrene-sulfonate grafted fluorinated ethylene propylene (FEP) membrane. The latter was found to outperform Nafion in terms of lowest attainable background signal (suppression efficacy) and dynamic suppression range...
December 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088722/in-situ-denitrification-and-dnra-rates-in-groundwater-beneath-an-integrated-constructed-wetland
#5
M M R Jahangir, O Fenton, C Müller, R Harrington, P Johnston, K G Richards
Evaluation of the environmental benefits of constructed wetlands (CWs) requires an understanding of their impacts on the groundwater quality under the wetlands. Empirical mass-balance (nitrogen in/nitrogen out) approaches for estimating nitrogen (N) removal in CWs do not characterise the final fate of N; where nitrate (NO3(-)-N) could be reduced to either ammonium (NH4(+)-N) or N2 with the potential for significant production of N2O. Herein, in situ denitrification and DNRA (dissimilatory nitrate reduction to ammonium) rates were measured in groundwater beneath cells of an earthen lined integrated constructed wetland (ICW, used to remove the nutrients from municipal wastewater) using the (15)N-enriched NO3(-)-N push-pull method...
January 7, 2017: Water Research
https://www.readbyqxmd.com/read/28088626/characterization-and-source-apportionment-of-pm2-5-based-on-error-estimation-from-epa-pmf-5-0-model-at-a-medium-city-in-china
#6
Baoshuang Liu, Jianhui Wu, Jiaying Zhang, Lu Wang, Jiamei Yang, Danni Liang, Qili Dai, Xiaohui Bi, Yinchang Feng, Yufen Zhang, Qinxun Zhang
Heze city, a medium-size city in Shandong province, Eastern China. Ambient PM2.5 samples were collected in urban area of Heze from August 2015 to April 2016, and chemical species and sources of PM2.5 were investigated in this paper. The results indicated that the average concentration of PM2.5 was 100.9 μg/m(3) during the sampling period, and the water-soluble ions, carbonaceous species included elemental carbon (EC) and organic carbon (OC), as well as elements contributed 32.7-51.7%, 16.3% and 12.5%, respectively, to PM2...
January 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28088117/adsorption-of-phosphate-from-aqueous-solution-using-iron-zirconium-modified-activated-carbon-nanofiber-performance-and-mechanism
#7
Weiping Xiong, Jing Tong, Zhaohui Yang, Guangming Zeng, Yaoyu Zhou, Dongbo Wang, Peipei Song, Rui Xu, Chen Zhang, Min Cheng
Phosphate (P) removal is significant for the prevention of eutrophication in natural waters. In this paper, a novel adsorbent for the removal of P from aqueous solution was synthesized by loading zirconium oxide and iron oxide onto activated carbon nanofiber (ACF-ZrFe) simultaneously. The adsorbent was characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The results showed that P adsorption was highly pH dependent and the optimum pH was found to be 4...
January 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28088096/mycelium-transformation-of-streptomyces-toxytricini-into-pellet-role-of-culture-conditions-and-kinetics
#8
Punit Kumar, Kashyap Kumar Dubey
The present study envisages the role of different carbon sources, nitrogen sources, metals, pH, inoculum volume and agitation rate in pellet formation of S. toxytricini at shake-flask level. It was found that galactose, ammonium sulphate, sodium nitrate, Cu(2+), Zn(2+), higher inoculum volume (5% v/v) and agitation rate at 300rpm caused significant reduction in pellet size (up to the range of 30μm-0.5mm) but biomass formations was also reduced subsequently. Interestingly diffused type of morphology was obtained in Fe(2+) supplemented medium with reduced biomass (1...
January 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28088024/multi-year-record-of-atmospheric-and-snow-surface-nitrate-in-the-central-antarctic-plateau
#9
R Traversi, S Becagli, M Brogioni, L Caiazzo, V Ciardini, F Giardi, M Legrand, G Macelloni, B Petkov, S Preunkert, C Scarchilli, M Severi, V Vitale, R Udisti
Continuous all year-round samplings of atmospheric aerosol and surface snow at high (daily to 4-day) resolution were carried out at Dome C since 2004-05 to 2013 and nitrate records are here presented. Basing on a larger statistical data set than previous studies, results confirm that nitrate seasonal pattern is characterized by maxima during austral summer for both aerosol and surface snow, occurring in-phase with solar UV irradiance. This temporal pattern is likely due to a combination of nitrate sources and post-depositional processes whose intensity usually enhances during the summer...
December 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/28087899/increasing-dietary-nitrate-has-no-effect-on-cancellous-bone-loss-or-fecal-microbiome-in-ovariectomized-rats
#10
Melissa N Conley, Cooper Roberts, Thomas J Sharpton, Urszula T Iwaniec, Norman Hord
Studies suggest diets rich in fruit and vegetables reduce bone loss, although the specific compounds responsible are unknown. Substrates for endogenous nitric oxide (NO) production, including organic nitrates and dietary nitrate, may support NO production in age-related conditions, including osteoporosis. We investigated the capability of dietary nitrate to improve NO bioavailability, reduce bone turnover and loss. Six-month-old Sprague Dawley rats [30 ovariectomized (OVX) and 10 sham-operated (sham)] were randomized into 3 groups: (1) vehicle (water) control, (2) low-dose nitrate (LDN, 0...
January 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28086862/management-of-dentin-hypersensitivity-by-national-dental-practice-based-research-network-practitioners-results-from-a-questionnaire-administered-prior-to-initiation-of-a-clinical-study-on-this-topic
#11
Dorota T Kopycka-Kedzierawski, Cyril Meyerowitz, Mark S Litaker, Sidney Chonowski, Marc W Heft, Valeria V Gordan, Robin L Yardic, Theresa E Madden, Stephanie C Reyes, Gregg H Gilbert
BACKGROUND: Dentin hypersensitivity (DH) is a common problem encountered in clinical practice. The purpose of this study was to identify the management approaches for DH among United States dentists. METHODS: One hundred eighty five National Dental Practice-Based Research Network clinicians completed a questionnaire regarding their preferred methods to diagnose and manage DH in the practice setting, and their beliefs about DH predisposing factors. RESULTS: Almost all dentists (99%) reported using more than one method to diagnose DH...
January 13, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28079248/inhibition-of-matrix-metalloproteinase-9-by-a-barbiturate-nitrate-hybrid-ameliorates-dextran-sulphate-sodium-induced-colitis-effect-on-inflammation-related-genes
#12
Shane O'Sullivan, Jun Wang, Maria T Pigott, Neil Docherty, Noreen Boyle, Samuel Kana Lis, John F Gilmer, Carlos Medina
BACKGROUND AND PURPOSE: Matrix metalloproteinase-9 is upregulated in Ulcerative Colitis and implicated in the pathology of the disease. In this study, we have examined the effects of a barbiturate-based MMP inhibitor incorporating a nitric oxide donor/mimetic group (dinitrate-barbiturate) in the intestinal injury induced by dextran sulphate sodium (DSS). EXPERIMENTAL APPROACH: In-vivo experiments were carried out using male Wistar rats given DSS 5% ad libitum in drinking water...
January 12, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28078050/complete-genome-sequence-of-lutibacter-profundi-lp1-t-isolated-from-an-arctic-deep-sea-hydrothermal-vent-system
#13
Juliane Wissuwa, Sven Le Moine Bauer, Ida Helene Steen, Runar Stokke
Lutibacter profundi LP1(T) within the family Flavobacteriaceae was isolated from a biofilm growing on the surface of a black smoker chimney at the Loki's Castle vent field, located on the Arctic Mid-Ocean Ridge. The complete genome of L. profundi LP1(T) is the first genome to be published within the genus Lutibacter. L. profundi LP1(T) consists of a single 2,966,978 bp circular chromosome with a GC content of 29.8%. The genome comprises 2,537 protein-coding genes, 40 tRNA species and 2 rRNA operons. The microaerophilic, organotrophic isolate contains genes for all central carbohydrate metabolic pathways...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28077606/correction-to-inorganic-nitrate-supplementation-lowers-blood-pressure-in-humans-role-for-nitrite-derived-no
#14
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Hypertension
https://www.readbyqxmd.com/read/28077208/aerobic-denitrification-and-biomineralization-by-a-novel-heterotrophic-bacterium-acinetobacter-sp-h36
#15
Jun Feng Su, Jing Xin Shi, Fang Ma
A novel aerobic denitrification and biomineralization strain H36 was isolated from the Qu Jiang artificial lake. Based on phylogenetic characteristics, the isolated strain was identified as Acinetobacter species. Strain H36 was confirmed to have the ability to perform simultaneous denitrification and biomineralization. Results showed the strain H36 had the capability to completely reduce 96.29% of NO3(-)-N and 78.59% of Ca(2+) over 112h under aerobic condition. Response surface methodology (RSM) analysis demonstrated the highest removal ratio of Ca(2+) was 74...
January 8, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28076700/correlation-between-acute-toxicity-for-daphnia-magna-aliivibrio-fischeri-and-physicochemical-variables-of-the-leachate-produced-in-landfill-simulator-reactors
#16
José J Barrios Restrepo, Letícia Flohr, Silvia P Melegari, Cristina H da Costa, Cristiane F Fuzinatto, Armando B de Castilhos, William G Matias
Due to the diversified nature of municipal solid waste (MSW) and the different stages of its decomposition, the formed leachates result in a complex chemical mixture with toxic potential. These chemicals can cause environmental problems, such as the contamination of surface or groundwater, thus affecting the balance of aquatic ecosystems. The aim of our study was to evaluate the acute toxicity of leachates in Daphnia magna and Aliivibrio fischeri and to identify the main physicochemical variables that influence the toxicity of the landfill leachates produced in reactors within pilot simulations...
January 11, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28076580/-cag-n-polymorphism-of-the-atxn2-gene-a-new-marker-of-susceptibility-for-type-2-diabetes-mellitus
#17
Luis J Flores-Alvarado, Nory O Dávalos-Rodríguez, Diana García-Cruz, Perla M Madrigal-Ruiz, Rosalba Ruiz-Mejía, María E Aguilar-Aldrete, Nemesio Villa-Ruano, Sergio Alberto Ramirez-Garcia
Objective: Estimate whether there is an association between the (CAG)n repeat in the ATXN2 gene in the Mexican population and type 2 diabetes mellitus (DM). Methods: Epidemiological case-control study, including healthy people and diabetics. (CAG)n expansion was detected by end-point polymerase chain reaction (PCR). PCR outputs were analyzed by electrophoresis (PAGE 8%) and silver nitrate staining. Results: (CAG)n nucleotide allele distribution in the study population was similar to that reported in central Mexico...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28075565/redox-couple-involving-nox-in-aerobic-pd-catalyzed-oxidation-of-sp-3-c-h-bonds-direct-evidence-for-pd-no3-no2-interactions-involved-in-oxidation-and-reductive-elimination
#18
Margot N Wenzel, Philippa K Owens, Joshua T W Bray, Jason M Lynam, Pedro M Aguiar, Christopher Reed, James D Lee, Jacqueline F Hamilton, Adrian C Whitwood, Ian J S Fairlamb
NaNO3 is used in oxidative Pd-catalyzed processes as a complementary co-catalyst to common oxidants, e.g., Cu(II) salts, in C-H bond activation and Wacker oxidation processes. NaNO3 and NaNO2 (with air or O2) assist the sp(3)-C-H bond acetoxylation of substrates bearing an N-directing group. It has been proposed previously that a redox couple is operative. The role played by NOx anions is examined in this investigation. Evidence for an NOx anion interaction at Pd(II) is presented. Palladacyclic complexes containing NOx anions are competent catalysts for acetoxylation of 8-methylquinoline, with and without exogenous NaNO3...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28074877/microwave-synthesized-freestanding-iron-carbon-nanotubes-on-polyester-composites-of-woven-kevlar-fibre-and-silver-nanoparticle-decorated-graphene
#19
Ankita Hazarika, Biplab K Deka, DoYoung Kim, Kyungil Kong, Young-Bin Park, Hyung Wook Park
We synthesized Ag nanoparticle-decorated multilayered graphene nanosheets (Ag-graphene) from graphite nanoplatelets and silver nitrate through 90-100 s of microwave exposure, without the use of any mineral acids or harsh reducing agents. Fe nanoparticle-decorated carbon nanotubes (Fe-CNTs) were grown on polypyrrole (PPy) deposited on woven Kevlar fibre (WKF), using ferrocene as a catalyst, under microwave irradiation. Fe-CNTs grown on WKF and Ag-graphene dispersed in polyester resin (PES) were combined to fabricate Ag-graphene/Fe-CNT/PPy-coated WKF/PES composites by vacuum-assisted resin transfer moulding...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074364/efficient-photo-catalytic-degradation-of-malachite-green-using-nickel-tungstate-material-as-photo-catalyst
#20
N Helaïli, A Boudjamaa, M Kebir, K Bachari
The present study focused on the evaluation of photo-catalytic and photo-electrochemical properties of the photo-catalyst based on nickel tungstate material prepared by a nitrate method through the degradation of malachite green (MG) dye's. The effect of catalyst loading and dye concentration was examined. Physico-chemical, optical, electrical, electrochemical, and photo-electrochemical properties of the prepared material were analyzed by X-ray diffraction (XRD), fourier transform-infrared spectroscopy (FTIR), BET analysis, optical reflectance diffuse (DR), scanning electron microscopy (SEM/EDX), electrical conductivity, cyclic voltammetry (CV), current intensity, mott-shottky, and nyquist...
January 10, 2017: Environmental Science and Pollution Research International
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