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Diabetes aqueous humor

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https://www.readbyqxmd.com/read/29746442/community-associated-methicillin-resistant-staphylococcus-aureus-subretinal-abscess-in-a-nonbacteremic-patient-treated-with-internal-drainage-and-retinectomy
#1
Jessica F Yang, Kamal Kishore
PURPOSE: To report a case of community-associated methicillin-resistant Staphylococcus aureus subretinal abscess that continued to progress, despite intravitreal and systemic antibiotic therapy. METHODS: Retrospective chart review of a 77-year-old female patient with well-controlled diabetes mellitus who developed a left eye endophthalmitis and subretinal abscess from methicillin-resistant S. aureus colonization in the absence of any systemic focus of infection...
May 9, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29743587/three-dimensional-tubule-formation-assay-as-therapeutic-screening-model-for-ocular-microvascular-disorders
#2
Mahnaz Shariatzadeh, Maarten M Brandt, Caroline Cheng, Josianne C Ten Berge, Aniki Rothova, Pieter J M Leenen, Willem A Dik
PURPOSE: This study is aimed to adapt a three-dimensional (3-D) in vitro angiogenesis model to the ophthalmology field using retinal endothelial cells (REC). This system is applied to assess the angiogenic capacity of aqueous humor (AH) from patients with ocular disorders, and to test the effect of VEGF inhibitor (aflibercept) on induced angiogenesis. METHODS: Human REC and umbilical vein endothelial cells (HUVEC) and pericytes were co-cultured in a gel matrix with 25-200 ng/ml pro-angiogenic growth factors (GF)...
May 10, 2018: Eye
https://www.readbyqxmd.com/read/29522144/aqueous-humor-cytokine-levels-and-anatomic-response-to-intravitreal-ranibizumab-in-diabetic-macular-edema
#3
Roxane J Hillier, Elvis Ojaimi, David T Wong, Michael Y K Mak, Alan R Berger, Radha P Kohly, Peter J Kertes, Farzin Forooghian, Shelley R Boyd, Kenneth Eng, Filiberto Altomare, Louis R Giavedoni, Rosane Nisenbaum, Rajeev H Muni
Importance: Variability in response to anti-vascular endothelial growth factor (VEGF) treatment in diabetic macular edema (DME) remains a significant clinical challenge. Biomarkers could help anticipate responses to anti-VEGF therapy. Objectives: To investigate aqueous humor cytokine level changes in response to intravitreal ranibizumab therapy for the management of DME, and to determine the association between baseline aqueous levels and anatomic response. Design, Setting, and Participants: In this prospective multicenter cohort study, 49 participants with diabetes mellitus complicated by center-involving DME, with a central subfield thickness of 310 μm or greater on spectral-domain optical coherence tomography (SD-OCT), were recruited from December 22, 2011, to June 13, 2013 and statistical analysis were performed from March 1, 2017, to June 1, 2017...
April 1, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29487034/isolates-and-antibiotic-susceptibilities-of-endogenous-bacterial-endophthalmitis-a-retrospective-multicenter-study-in-japan
#4
Daisuke Todokoro, Kiyofumi Mochizuki, Takashi Nishida, Hiroshi Eguchi, Tatsuro Miyamoto, Takaaki Hattori, Takashi Suzuki, Tomoyuki Inoue, Ryohei Nejima, Saichi Hoshi, Hideo Akiyama
Endogenous bacterial endophthalmitis, also called metastatic endophthalmitis, is a rare bacterial endophthalmitis derived from distant infectious foci via the bloodstream. This infection can potentially cause not only severe visual disturbance, but also loss of the eyeball or death, as most patients are immunocompromised. This retrospective Japanese multicenter study analyzed 32 eyes in 25 definitive cases. Twelve patients (48.0%) had diabetes mellitus. Typical ocular findings were vitreous haze (87.5%), cells in the anterior chambers (62...
June 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29392317/association-between-soluble-cd14-in-the-aqueous-humor-and-hyperreflective-foci-on-optical-coherence-tomography-in-patients-with-diabetic-macular-edema
#5
Hyungwoo Lee, Hyoik Jang, Youn A Choi, Hyung Chan Kim, Hyewon Chung
Purpose: To investigate the associations between soluble CD14 (sCD14), a cytokine released by microglia and macrophages, and hyperreflective foci (HF) and various characteristics of spectral-domain optical coherence tomography (SD-OCT) in diabetic macular edema (DME). Methods: Sixty-nine eyes from 51 patients with DME and 28 eyes from 28 control subjects were studied. sCD14 levels in the aqueous humor (AH) were measured using ELISA before bevacizumab injection (IVB), and the associations between sCD14 and visual acuity, the number of HF, retinal volume, and the DME pattern were assessed...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29259898/clinical-and-experimental-study-on-angiopoietin-like-protein-8-associated-with-proliferative-diabetic-retinopathy
#6
Chang-Xia Dong, Cai-Ping Song, Chun-Ping Zhang, Mei Dong, Xiu-Rong Gong, He-Ying Gao, Hong Wang
AIM: To confirm the role of angiopoietin-like protein 8 (Angptl 8) in proliferative diabetic retinopathy (PDR). METHODS: The sera and aqueous humor of 10 PDR patients and 10 non-diabetic retinopathy (NDR) patients (idiopathic macular hole patients) were collected and the expression of Angptl 8 was detected by enzyme linked immune-sorbent assay (ELISA). Experimental diabetes mice model was induced with streptozotocin. The expression of glycosylated hemoglobin and Angptl 8 in sera was detected...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29177891/plasma-levels-of-hypoxia-regulated-factors-in-patients-with-age-related-macular-degeneration
#7
Zygoula Ioanna, Schori Christian, Grimm Christian, Barthelmes Daniel
PURPOSE: Various hypoxia-related proteins are differentially expressed in the retina and secreted to the vitreous and/or aqueous humor of patients affected by dry or neovascular age-related macular degeneration (nAMD). To determine whether these conditions alter concentrations of cytokines also in the systemic circulation, we measured plasma levels of six hypoxia-related proteins. METHODS: Plasma was prepared from EDTA blood that was collected from patients affected by dry AMD (n = 5), nAMD (n = 11), proliferative diabetic retinopathy (PDR; n = 9), and patients with an epiretinal membrane (ERM; n = 11)...
February 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28969616/assessment-of-biomarkers-using-multiplex-assays-in-aqueous-humor-of-patients-with-diabetic-retinopathy
#8
Hui Chen, Xiongze Zhang, Nanying Liao, Feng Wen
BACKGROUND: With the high prevalence of type 2 diabetes, diabetic retinopathy (DR) has become a leading health problem worldwide. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. The purpose of this study was to assess the levels of immune and inflammatory biomarkers in the aqueous humor of patients with different severities of DR and to analyze the correlations between Interleukin-6 (IL-6) and these biomarkers, and between IL-6 and the severity of the disease...
October 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28800629/protective-effects-on-the-retina-after-ranibizumab-treatment-in-an-ischemia-model
#9
Stephanie C Joachim, Marina Renner, Jacqueline Reinhard, Carsten Theiss, Caroline May, Stephanie Lohmann, Sabrina Reinehr, Gesa Stute, Andreas Faissner, Katrin Marcus, H Burkhard Dick
Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular occlusion. The goal of this study was to evaluate the potential protective effects of an intravitreally injected vascular endothelial growth factor (VEGF) inhibitor (ranibizumab) on retinal cells in an ischemia animal model via immunohistochemistry (IF) and quantitative real-time PCR (PCR). A positive binding of ranibizumab to rat VEGF-A was confirmed via dot blot. One eye underwent ischemia and a subgroup received ranibizumab...
2017: PloS One
https://www.readbyqxmd.com/read/28741232/serum-and-aqueous-humor-concentrations-of-interleukin-27-in-diabetic-retinopathy-patients
#10
Maha E Houssen, Mona Abo Bakr El-Hussiny, Amr El-Kannishy, Dalia Sabry, Rasha El Mahdy, Mohamed E Shaker
PURPOSE: Interleukin (IL)-27 has been reported to possess anti- and proinflammatory properties in several immune related-disorders, but its role in diabetic retinopathy is still elusive. Here, we aimed to (i) evaluate IL-27 concentrations in serum and aqueous humor of diabetic patients with or without retinopathy and (ii) test whether IL-27 is correlated with some risk factors of diabetic retinopathy. METHODS: The study comprised 60 diabetic patients with and without retinopathy along with 20 healthy controls...
July 24, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28680705/association-between-aqueous-cytokines-and-diabetic-retinopathy-stage
#11
Hailiang Wu, De-Kuang Hwang, Xudong Song, Yong Tao
PURPOSE: To measure the concentrations of various cytokines in the aqueous humor from patients with different stages of diabetic retinopathy. METHODS: All selected cataract patients were categorized into 4 groups: the control group (patients without diabetes), nonretinopathy (NDR) group (diabetic patients without retinopathy), nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. The aqueous concentrations of interleukin- (IL-) 1β, IL-2, IL-4, IL-5, IL-6, IL-10, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor (VEGF) from patients were measured using the cytometric bead array technique...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28574494/aqueous-humor-pentraxin-3-levels-in-patients-with-diabetes-mellitus
#12
M Mutlu, N Yuksel, T Takmaz, A S Dincel, A Bilgihan, H Altınkaynak
PurposeTo evaluate aqueous humor (AH) pentraxin-3 (PTX3) levels in diabetic patients with and without diabetic retinopathy (DR).MethodsIn this prospective study, patients undergoing cataract surgery were enrolled. The study group was composed of 26 type-2 diabetic patients without DR (group 1), 32 diabetic patients with DR (group 2) and 29 age-matched subjects without any systemic disease (group 3). Fifteen proliferative DR (PDR) and 17 non-proliferative DR (NPDR) patients were enrolled in Group 2. HbA1c levels and duration of diabetes were noted...
October 2017: Eye
https://www.readbyqxmd.com/read/28564655/aqueous-humor-levels-of-soluble-vascular-endothelial-growth-factor-receptor-and-inflammatory-factors-in-diabetic-macular-edema
#13
Hidetaka Noma, Tatsuya Mimura, Kanako Yasuda, Ryosuke Motohashi, Osamu Kotake, Masahiko Shimura
Aqueous levels of soluble vascular endothelial growth factor receptor (sVEGFR) and inflammatory factors were measured in 35 patients (37 eyes) with diabetic macular edema (DME) receiving anti-vascular endothelial growth factor (VEGF) therapy. Aqueous levels of growth factors (VEGF, placental growth factor [PlGF], and platelet-derived growth factor AA [PDGF-AA]), sVEGFR-1 and -2, soluble intercellular adhesion molecule 1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, -8, -12, and -13, and interferon-inducible 10-kDa protein (IP-10) were significantly higher in the DME group than in the nondiabetic control group...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28558009/association-between-aqueous-humor-and-vitreous-fluid-levels-of-th17-cell-related-cytokines-in-patients-with-proliferative-diabetic-retinopathy
#14
Masaru Takeuchi, Tomohito Sato, Yutaka Sakurai, Manzo Taguchi, Kozo Harimoto, Yoko Karasawa, Masataka Ito
Inflammation is known to be involved in the progression of diabetic retinopathy. We have recently reported that vitreous levels of IL-4, IL-17A, IL-22, IL-31, and TNFα are higher than the respective serum levels in proliferative diabetic retinopathy (PDR) patients, and that vitreous levels of these cytokines are higher in PDR than in other non-inflammatory vitreoretinal diseases or uveitis associated with sarcoidosis. In the present study, we investigated inflammatory cytokines including Th17 cell-related cytokines in aqueous humor samples obtained from eyes with PDR, and analyzed the association between the aqueous humor and vitreous fluid levels of individual cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28548649/aqueous-humor-endothelin-1-and-total-retinal-blood-flow-in-patients-with-non-proliferative-diabetic-retinopathy
#15
L-A Khuu, F Tayyari, J M Sivak, J G Flanagan, S Singer, M H Brent, D Huang, O Tan, C Hudson
PurposeThe purpose of this study was to determine the association between aqueous ET-1 levels and total retinal blood flow (TRBF) in patients with non-insulin-dependent type 2 diabetes mellitus (T2DM) and early non-proliferative diabetic retinopathy (NPDR).Patients and methodsA total of 15 age-matched controls and 15 T2DM patients with NPDR were recruited into the study. Aqueous humor (~80-120 μl) was collected before cataract surgery to measure the levels of ET-1 using suspension multiplex array technology...
October 2017: Eye
https://www.readbyqxmd.com/read/28510630/local-and-systemic-inflammatory-biomarkers-of-diabetic-retinopathy-an-integrative-approach
#16
REVIEW
Stela Vujosevic, Rafael Simó
Purpose: To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods: An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochemical biomarkers related to inflammation at early and advanced stages of DR (including diabetic macular edema [DME] and proliferative DR) was performed...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28497987/elevated-activating-transcription-factor-4-and-glucose-regulated-78-kda-protein-levels-correlate-with-inflammatory-cytokines-in-the-aqueous-humor-and-vitreous-of-proliferative-diabetic-retinopathy
#17
Yanuo Wang, Sha Gao, Yanji Zhu, Xi Shen
PURPOSE: To determine concentrations of endoplasmic reticulum (ER) stress-related factors activating transcription factor 4 (ATF4) and glucose-regulated 78 kDa protein (GRP78) in vitreous and aqueous humor (AqH) of patients with proliferative diabetic retinopathy (PDR) and the correlation of ATF4, GRP78 and inflammatory cytokines interleukin-6(IL-6) and monocyte chemoattractant protein-1 (MCP-1). MATERIALS AND METHODS: AqH and vitreous samples were collected from eyes of patients with PDR and idiopathic macular hole (IMH) which needed vitrectomy...
August 2017: Current Eye Research
https://www.readbyqxmd.com/read/28469465/characterization-of-vitreous-and-aqueous-proteome-in-humans-with-proliferative-diabetic-retinopathy-and-its-clinical-correlation
#18
Sankarathi Balaiya, Zimei Zhou, Kakarla V Chalam
AIMS: Proliferative diabetic retinopathy (PDR) is associated with microvascular complications that cause biochemical changes in the human retina and alter the proteome of vitreous humor and aqueous humor (AH). METHODS: Human vitreous humor and AH of PDR subjects were collected. Subjects who had surgery for epiretinal membrane or macular hole served as controls. Protein profiles were obtained and analyzed after running the samples on a liquid chromatography-mass spectrometry/mass spectrometry...
2017: Proteomic Insights
https://www.readbyqxmd.com/read/28455954/galectin-1-expression-imprints-a-neurovascular-phenotype-in-proliferative-retinopathies-and-delineates-responses-to-anti-vegf
#19
Magali E Ridano, Paula V Subirada, María C Paz, Valeria E Lorenc, Juan C Stupirski, Ana L Gramajo, José D Luna, Diego O Croci, Gabriel A Rabinovich, María C Sánchez
Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is still limited. As retinal impairment involves abnormal neovascularization and neuronal degeneration, we evaluated here the involvement of galectin-1 in vascular and non-vascular alterations associated with retinopathies, using the oxygen-induced retinopathy (OIR) model. Postnatal day 17 OIR mouse retinas showed the highest neovascular profile and exhibited neuro-glial injury as well as retinal functional loss, which persisted until P26 OIR...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427061/emerging-insights-into-pathogenesis
#20
REVIEW
Edoardo Midena, Elisabetta Pilotto
Diabetic retinopathy (DR) is a frequent complication of diabetes mellitus (DM). Persistent hyperglycemia leads to the activation of multiple cellular pathways involved in the pathogenesis of DR, resulting in increased inflammation, oxidative stress, and vascular dysfunction. DR has been considered a "chronic, low-grade inflammatory disease of the retina". However, an increasing body of evidence suggests that inflammation and neurodegeneration both occur in human diabetes even before the development of clinical signs of DR...
2017: Developments in Ophthalmology
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