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Eye banking

Sotiria Palioura, Kathryn Colby
PURPOSE: To evaluate the feasibility of Descemet stripping endothelial keratoplasty using grafts preloaded by an eye bank in a commercially available insertion device. METHODS: In this retrospective case series, a series of 35 eyes in 34 consecutive patients who underwent Descemet stripping endothelial keratoplasty for Fuchs endothelial dystrophy or previously failed full-thickness grafts at a single tertiary care center from March 2013 to March 2014 was included...
October 12, 2016: Cornea
Zachary M Mayko, Beth Ann Benetz, Harry Menegay, Christopher P Donovan, Christopher G Stoeger, Mark A Terry, Jonathan H Lass
PURPOSE: To evaluate a single eye bank's measurement of endothelial cell density (ECD) of Descemet membrane endothelial keratoplasty (DMEK) grafts before and after preparation using 2 separate counting methods. METHODS: A series of 60 donor tissues were prepared for DMEK surgery. One to 4 specular images of the central endothelium were taken both before and after preparation, and ECDs were evaluated for a total of 345 unique images. Images were then masked and provided to the Cornea Image Analysis Reading Center (CIARC) for independent analysis...
October 12, 2016: Cornea
Sonja Heinzelmann, Daniel Böhringer, Philipp Eberwein, Thomas Reinhard, Philip Maier
PURPOSE: Although the functional results following DMEK are better than after DSAEK, DSAEK still seems to be the standard procedure, as surgeons fear losing grafts during DMEK graft preparation. Therefore, eye banks offer precut DMEK grafts for direct use by the surgeon. Here, we analysed the functional results and complication rates for a precut technique compared to fresh preparations. METHODS: We retrospectively compared 453 standard to 11 precut (1-2 days before surgery) DMEK cases...
October 8, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Jyoti Khadka, Eva Fenwick, Ecosse Lamoureux, Konrad Pesudovs
PURPOSE: There is an increasing demand for high-standard, comprehensive, and reliable patient-reported outcome (PRO) instruments in all the disciplines of health care including in ophthalmology and optometry. Over the past two decades, a plethora of PRO instruments have been developed to assess the impact of eye diseases and their treatments. Despite this large number of instruments, significant shortcomings exist for the measurement of ophthalmic quality of life (QoL). Most PRO instruments are short-form instruments designed for clinical use, but this limits their content coverage often poorly targeting any study population other than that which they were developed for...
September 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Christopher F Blodi
David Kasner, MD (1927-2001), used his extensive dissections of eye bank eyes and experiences in teaching cataract surgery to resident physicians to realize that excision of vitreous when present in the anterior chamber of eyes undergoing cataract surgery was preferable to prior intraoperative procedures. Noting that eyes tolerated his maneuvers, he then performed planned subtotal open-sky vitrectomies; first on a traumatized eye in 1961, then on two eyes of patients with amyloidosis (1966-1967). The success of these operations was noted by others, most particularly Robert Machemer, MD...
2016: Ophthalmology and Eye Diseases
Mor M Dickman, Pieter J Kruit, Lies Remeijer, Jeroen van Rooij, Allegonda Van der Lelij, Robert H J Wijdh, Frank J H M van den Biggelaar, Tos T J M Berendschot, Rudy M M A Nuijts
OBJECTIVE: To compare visual acuity, refraction, endothelial cell density (ECD), and complications after Descemet stripping automated endothelial keratoplasty (DSAEK) and ultrathin DSAEK (UT-DSAEK). DESIGN: A multicenter, prospective, double-masked, randomized, controlled clinical trial. PARTICIPANTS: From 66 patients with irreversible corneal endothelial dysfunction dues to Fuchs' dystrophy who enrolled from 4 tertiary medical centers in the Netherlands, 66 eyes were studied...
September 19, 2016: Ophthalmology
Z Q Pan, Q F Liang
Corneal transplantation is an important method in the treatment of corneal blindness. It is imperative to improve the treatment effectiveness of corneal disease and reduce the possibility of corneal blindness with the progress of corneal transplantation surgery, the construction and development of eye banks and the rational use of donor materials. This article reviews the component corneal transplantation technology promotion, eye bank construction and preparation of donor slices for component corneal transplantation surgery...
September 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Bia Z Kim, Jay J Meyer, Nigel H Brookes, S Louise Moffatt, Helen C Twohill, David G Pendergrast, Trevor Sherwin, Charles N J McGhee
AIMS: To report the 25-year longitudinal trends in indications and corneal transplantation techniques in New Zealand. METHODS: Statistical analysis of prospectively acquired New Zealand National Eye Bank (NZNEB) electronic database from 1991 to 2015 inclusive. Subjects were recipients of corneal transplants in 62 centres supplied by the NZNEB. Main outcome measures were indications, recipient age and transplantation techniques. RESULTS: From January 1991 to December 2015, NZNEB supplied tissue for 5574 corneal transplants, increasing annually from 89 (1991) to 290 (2015)...
September 15, 2016: British Journal of Ophthalmology
Ricardo M Nosé, Fabio B Daga, Walton Nosé, Niro Kasahara
PURPOSE: To evaluate the efficacy of mannitol solution as a decontamination agent on the chemical burn of the human corneas. METHODS: Eight donor corneas from an eye bank were exposed to 25μl of 2.5% hydrofluoric acid (HF) solution on a filter paper for 20s. Three eyes were rinsed with 1000ml of mannitol 20% for 15min immediately after removal of the filter paper, 3 other were rinsed with sodium chloride (NaCl) 0.9% (1000ml for 15min) and two eyes were not rinsed...
September 5, 2016: Burns: Journal of the International Society for Burn Injuries
Alex S Huang, Sindhu Saraswathy, Anna Dastiridou, Alan Begian, Chirayu Mohindroo, James C H Tan, Brian A Francis, David R Hinton, Robert N Weinreb
PURPOSE: To assess the ability of trabecular micro-bypass stents to improve aqueous humor outflow (AHO) in regions initially devoid of AHO as assessed by aqueous angiography. METHODS: Enucleated human eyes (14 total from 7 males and 3 females [ages 52-84]) were obtained from an eye bank within 48 hours of death. Eyes were oriented by inferior oblique insertion, and aqueous angiography was performed with indocyanine green (ICG; 0.4%) or fluorescein (2.5%) at 10 mm Hg...
September 1, 2016: Investigative Ophthalmology & Visual Science
William W Sprague, Emily A Cooper, Sylvain Reissier, Baladitya Yellapragada, Martin S Banks
Blur from defocus can be both useful and detrimental for visual perception: It can be useful as a source of depth information and detrimental because it degrades image quality. We examined these aspects of blur by measuring the natural statistics of defocus blur across the visual field. Participants wore an eye-and-scene tracker that measured gaze direction, pupil diameter, and scene distances as they performed everyday tasks. We found that blur magnitude increases with increasing eccentricity. There is a vertical gradient in the distances that generate defocus blur: Blur below the fovea is generally due to scene points nearer than fixation; blur above the fovea is mostly due to points farther than fixation...
August 1, 2016: Journal of Vision
Adam K Muzychuk, Marie-Claude Robert, Stanley Dao, Mona Harissi-Dagher
PURPOSE: To compare the long-term clinical outcomes of fresh versus frozen corneal graft carriers for the Boston Keratoprosthesis type 1 (B-KPro). DESIGN: Prospective, single-center, nonblinded, randomized controlled trial. All participants were followed through the initial study protocol of 24 months and were approached to enter an extension phase, with continuing follow-up visits to 60 months. PARTICIPANTS: All patients undergoing B-KPro surgery between October 2008 and December 2009 by a single experienced surgeon at the Centre Hospitalier de l'Université de Montréal using an allograft carrier were considered...
August 24, 2016: Ophthalmology
Thomas John, Alpesh Patel, Abhay Vasavada, Man Singh, Vandana Nath, Anny M S Cheng, Hosam Sheha
PURPOSE: To evaluate the effect of trypan blue on the elastic property of Descemet membrane (DM) by atomic force microscopy. METHODS: Human corneas (n = 10) were obtained from the Illinois Eye Bank (Chicago, IL). The DM was isolated and divided into two halves, one half was stained with ophthalmic trypan blue (Vision Blue, 0.06%, DORC International), whereas the unstained other half served as control. The DM samples were then tested using the atomic force microscope...
November 2016: Cornea
Mojgan Padash Barmchi, Mary Gilbert, Miranda Thomas, Lawrence Banks, Bing Zhang, Vanessa J Auld
Cervical cancer is one of the leading causes of cancer death in women worldwide. The causative agents of cervical cancers, high-risk human papillomaviruses (HPVs), cause cancer through the action of two oncoproteins, E6 and E7. The E6 oncoprotein cooperates with an E3 ubiquitin ligase (UBE3A) to target the p53 tumour suppressor and important polarity and junctional PDZ proteins for proteasomal degradation, activities that are believed to contribute towards malignancy. However, the causative link between degradation of PDZ proteins and E6-mediated malignancy is largely unknown...
August 2016: PLoS Pathogens
Jyoti Khadka, Eva K Fenwick, Ecosse L Lamoureux, Konrad Pesudovs
PURPOSE: To explore whether large item sets, as used in item banking, enable important latent traits, such as driving, to form stand-alone measures. METHODS: The 88-item activity limitation (AL) domain of the glaucoma module of the Eye-tem Bank was interviewer-administered to patients with glaucoma. Rasch analysis was used to calibrate all items in AL domain on the same interval-level scale and test its psychometric properties. Based on Rasch dimensionality metrics, the AL scale was separated into subscales...
August 17, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Ji Won Kwon, Gabriel M Rand, Kyong Jin Cho, Patrick K Gore, Mitchell D McCartney, Roy S Chuck
PURPOSE: To evaluate the association between corneal endothelial cell density (ECD) and donor topical glaucoma medication use in an eye bank database. METHODS: Raw eye bank data included 19,159 donors over the period July 2007 to May 2015. Free-text, donor medication lists were retrospectively searched for glaucoma medication. Exclusion criteria were age less than 40 years, history of eye surgery, endothelial trauma, guttae, and cell densities <1000 or >3300/mm...
August 3, 2016: Cornea
S L AlTaan, K Termote, M S Elalfy, E Hogan, R Werkmeister, L Schmetterer, S Holland, H S Dua
PurposeTo define optical coherence tomography (OCT) characteristics of type-1, type-2, and mixed big bubbles (BB) seen in deep anterior lamellar keratoplasty.MethodsHuman sclero-corneal discs were obtained from UK (30) and Canada (16) eye banks. Air was injected into corneal stroma until a BB formed. UK samples were fixed in formalin before scanning with Fourier-domain (FD-OCT). One pair of each type of BB was scanned fresh. All BB obtained from Canada were scanned fresh with time-domain (TD-OCT). For each OCT machine used, type-1 BB from which Descemets membrane (DM) was partially peeled, were also scanned...
July 29, 2016: Eye
D S J Ting, J Potts, M Jones, T Lawther, W J Armitage, F C Figueiredo
PurposeTo report the changing trend in the utilisation rate of donated corneas for keratoplasty and to examine the reasons for unutilised corneas in the North East of England.MethodsRelevant data were retrospectively collected from a local eye retrieval database and the UK Transplant Registry for two separate years; namely, 2006 and 2010.ResultsThe utilisation rate of donated corneas for keratoplasty improved from 57% (52/92) in 2006 to 71% (220/312) in 2010 (P=0.012). Over the same period, there was a marked reduction of failed serological test results from 24% (22/92) to 5% (14/312) (P<0...
July 29, 2016: Eye
Marielle van Deemter, Ruud A Bank, Jelle Vehof, Johanna M M Hooymans, Leonoor I Los
PURPOSE: To explore factors associated with pentosidine accumulation in the human vitreous. METHODS: Vitreous samples were obtained during trans pars plana vitrectomy for macular hole or rhegmatogenous retinal detachment. Patient characteristics included age, gender, and diabetes mellitus. Ocular characteristics included pseudophakia, posterior vitreous detachment, and presence of intraocular fibrosis (epiretinal membrane, proliferative vitreoretinopathy, or both)...
July 26, 2016: Retina
Wimolwan Tangpagasit, Thanichaya Reanpinyawat
OBJECTIVE: To determine the eye integrity preservation after urgent penetrating keratoplasty (PKP) for corneal ulcer at Thammasat University Hospital. MATERIAL AND METHOD: A retrospective review of patients who underwent urgent PKP between September 2005 and January 2015 was conducted. Demographic data, predisposing factors, organisms, indication for surgery, time of urgent corneal graft registry, and preservation rate of eye integrity were analyzed. RESULTS: Fifty-five patients (55 eyes) registered for urgent corneal graft registry from eye bank and 22 eyes underwent urgent PKP There were 14 males (63...
January 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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