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https://www.readbyqxmd.com/read/28345565/upgradation-and-modernization-of-eye-banking-services-integrating-tradition-with-innovative-policies-and-current-best-practices
#1
Radhika Tandon, Archita Singh, Noopur Gupta, M Vanathi, Vivek Gupta
PURPOSE: The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. METHODS: Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28335564/passage-through-the-ocular-barriers-and-beneficial-effects-in-retinal-ischemia-of-topical-application-of-pacap1-38-in-rodents
#2
Dora Werling, William A Banks, Therese S Salameh, Timea Kvarik, Laszlo Akos Kovacs, Alexandra Vaczy, Edina Szabo, Flora Mayer, Rita Varga, Andrea Tamas, Gabor Toth, Zsolt Biro, Tamas Atlasz, Dora Reglodi
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has two active forms, PACAP1-27 and PACAP1-38. Among the well-established actions are PACAP's neurotrophic and neuroprotective effects, which have also been proven in models of different retinopathies. The route of delivery is usually intravitreal in studies proving PACAP's retinoprotective effects. Recently, we have shown that PACAP1-27 delivered as eye drops in benzalkonium-chloride was able to cross the ocular barriers and exert retinoprotection in ischemia...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28317856/a-smartphone-based-diagnostic-platform-for-rapid-detection-of-zika-chikungunya-and-dengue-viruses
#3
Aashish Priye, Sara W Bird, Yooli K Light, Cameron S Ball, Oscar A Negrete, Robert J Meagher
Current multiplexed diagnostics for Zika, dengue, and chikungunya viruses are situated outside the intersection of affordability, high performance, and suitability for use at the point-of-care in resource-limited settings. Consequently, insufficient diagnostic capabilities are a key limitation facing current Zika outbreak management strategies. Here we demonstrate highly sensitive and specific detection of Zika, chikungunya, and dengue viruses by coupling reverse-transcription loop-mediated isothermal amplification (RT-LAMP) with our recently developed quenching of unincorporated amplification signal reporters (QUASR) technique...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317665/preparation-of-ultrathin-grafts-for-descemet-stripping-endothelial-keratoplasty-with-a-single-microkeratome%C3%A2-pass
#4
Vito Romano, Bernhard Steger, Jayavani Myneni, Mark Batterbury, Colin E Willoughby, Stephen B Kaye
We present a technique to achieve ultrathin Descemet-stripping automated endothelial keratoplasty (DSAEK). Using a simple method of controlling artificial anterior chamber pressure and drying the corneal surface, it was possible to thin the donor cornea at a rate of 11 μm a minute. When the donor cornea was between 500 μm and 510 μm, a single pass was made using a 350 μm microkeratome head followed by a peripheral dissection. The resulting mean graft thickness was 83.2 μm ± 14.9 (SD) (range 50 to 98 μm) with a mean peripheral graft edge thickness of 106...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28306601/assessing-the-impact-of-diabetes-mellitus-on-donor-corneal-endothelial-cell-density
#5
Chase A Liaboe, Benjamin T Aldrich, Pamela C Carter, Jessica M Skeie, Kimberlee A Burckart, Gregory A Schmidt, Cynthia R Reed, M Bridget Zimmerman, Mark A Greiner
PURPOSE: To quantify changes in endothelial cell density (ECD) of donor corneal tissue in relation to the presence or absence of a medical history of diabetes mellitus diagnosis, treatment, and complications. METHODS: A retrospective review was performed for all corneas collected at Iowa Lions Eye Bank between January 2012 and December 2015. For purposes of analysis, donor corneas were divided into 4 groups: nondiabetic, non-insulin-dependent diabetic, insulin-dependent diabetic without medical complications due to diabetes, and insulin-dependent diabetic with medical complications due to diabetes...
March 16, 2017: Cornea
https://www.readbyqxmd.com/read/28263034/analysis-of-the-learning-curve-for-pre-cut-corneal-specimens-in-preparation-for-lamellar-transplantation-a-prospective-single-centre-consecutive-case-series-prepared-at-the-lions-new-south-wales-nsw-eye-bank
#6
Aifric Isabel Martin, Rajnesh Devasahayam, Christopher Hodge, Simon Cooper, Gerard L Sutton
IMPORTANCE: This study represents the first paper to establish a learning curve by a single technician. BACKGROUND: Preparation of pre-cut corneal endothelial grafts commenced at Lions New South Wales Eye Bank in December 2014. The primary objective of this study was to review the safety and reliability of the preparation method during the first year of production. DESIGN: Hospital-based, prospective case series PARTICIPANTS: 234 consecutive donor corneal lenticules METHODS: Donor lenticules were prepared by a single operator using a linear cutting microkeratome...
March 6, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28257386/rapid-warming-of-donor-corneas-is-safe-and-improves-specular-image-quality
#7
Khoa D Tran, Jameson Clover, Amy Ansin, Christopher G Stoeger, Mark A Terry
PURPOSE: To determine whether warming donor corneas to near-physiological temperatures can safely shorten warming times while providing high-quality specular images during tissue evaluation. METHODS: Mated corneas were warmed at room temperature (RT) or at 35°C for 4 hours upon removal from cold storage. Specular images and endothelial cell densities were acquired and rated every hour. Additional mated corneas were subjected to 2 rounds of 4-hour incubation at either RT or 35°C...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28257380/corneal-transplantation-in-auckland-new-zealand-1999-2009-indications-patient-characteristics-ethnicity-social-deprivation-and-access-to-services
#8
Alexandra Z Crawford, James McKelvie, Jennifer P Craig, Charles N J McGhee, Dipika V Patel
PURPOSE: To analyze characteristics and indications for corneal transplantation in patients undergoing penetrating, lamellar, and endothelial keratoplasty in Auckland, New Zealand (NZ). METHODS: Corneal transplantation data from the NZ National Eye Bank and hospital records of corneal transplant recipients in the Auckland region from January 1, 2000, to December 31, 2009, were collated. Patient demographics, preoperative diagnosis, indication, ocular and medical history, visual acuity, deprivation index, and access to transplantation surgery were analyzed...
March 1, 2017: Cornea
https://www.readbyqxmd.com/read/28222686/ipsiversive-ictal-eye-deviation-in-inferioposterior-temporal-lobe-epilepsy-two-seeg-cases-report
#9
Wei Zhang, Xingzhou Liu, Lijun Zuo, Qiang Guo, Qi Chen, Yongjun Wang
BACKGROUND: Versive seizure characterized by conjugate eye movement during epileptic seizure has been considered commonly as one of the most valuable semiological signs for epilepsy localization, especially for frontal lobe epilepsy. However, thelateralizing and localizing significance of ictaleye deviation has been questioned by clinical observation of a series of focal epilepsy studies, including frontal, central, temporal, parietal and occipital epilepsy. CASE PRESENTATION: Two epileptic cases characterized by ipsiversive eye deviation as initial clinical sign during the habitual epileptic seizures are presented in this paper...
February 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28146443/developing-an-item-bank-to-measure-quality-of-life-in-individuals-with-glaucoma-and-the-results-of-the-interview-with-patients-the-effect-of-visual-function-visual-field-progression-rate-medical-and-surgical-treatments-on-quality-of-life
#10
Masato Matsuura, Kazunori Hirasawa, Hiroyo Hirasawa, Mieko Yanagisawa, Hiroshi Murata, Chihiro Mayama, Ryo Asaoka
PURPOSE: To construct a new item bank to measure quality of life (QOL) in glaucoma patients and to evaluate glaucoma patients' QOL using the item bank. METHODS: An item bank of questions was generated through a literature review of QOL instruments useful for glaucoma patients. Using this item bank, a cognitive survey was performed on 203 patients with glaucoma (112 males and 91 females, 61.9±11.9 y old; mean±SD). The results were then analyzed using the Rasch analysis, and the Rasch-derived disability scores were predicted using linear modelling and the following clinical parameters: age, mean total deviation (mTD) in superior and inferior visual field (mTDsup/mTDinf), mTD progression rate, better visual acuity, worse visual acuity, number of eye drops administered per day, number of trabeculectomy procedures experienced in both eyes...
February 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28129302/evaluation-and-quality-assessment-of-prestripped-preloaded-descemet-membrane-endothelial-keratoplasty-grafts
#11
Khoa D Tran, Philip K Dye, Kelly Odell, Joshua Galloway, Christopher G Stoeger, Michael D Straiko, Mark A Terry
PURPOSE: To determine graft quality and feasibility of Descemet membrane endothelial keratoplasty (DMEK) grafts that are prestripped and preloaded into injectors by eye bank technicians before shipping to surgeons. METHODS: DMEK grafts (n = 31) were prepared from donor corneas and preloaded into Straiko Modified Jones tubes and set inside viewing chambers filled with 20 mL of Optisol-GS. Preloaded grafts were evaluated using specular microscopy and slit-lamp biomicroscopy...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28116630/corneal-transplantation-study-of-the-data-of-a-regional-eye-bank-for-the-year-2013-and-analysis-of-the-evolution-of-the-adverse-events-reported-in-france-since-2010
#12
Anne-Sophie Gauthier, Marie Castelbou, Mélanie Bidaut Garnier, Joëlle Pizzuto, Stephan Roux, Philippe Gain, Fabienne Pouthier, Bernard Delbosc
To analyze the data of the adverse events collected in a single major eye bank (EFS Bourgogne Franche Comté, Besançon, France) for the year 2013 and to report the French data of biovigilance provided by the French National Agency for Medicines and Health Products Safety (ANSM) between 2010 and 2013. we have set up a study of adverse events in 2013, in collaboration with a single eye bank (EFS Bourgogne Franche Comté, Besançon, France). A survey was sent to the surgeon for each delivered corneal button by the eye bank in 2013...
March 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28114577/biomechanical-strengthening-of-the-human-cornea-induced-by-nanoplatform-based-transepithelial-riboflavin-uv-a-corneal-cross-linking
#13
Cristina Labate, Marco Lombardo, Giuseppe Lombardo, Maria Penelope De Santo
Purpose: The purpose of this study was to investigate the biomechanical stiffening effect induced by nanoplatform-based transepithelial riboflavin/UV-A cross-linking protocol using atomic force microscopy (AFM). Methods: Twelve eye bank donor human sclerocorneal tissues were investigated using a commercial atomic force microscope operated in force spectroscopy mode. Four specimens underwent transepithelial corneal cross-linking using a hypotonic solution of 0.1% riboflavin with biodegradable polymeric nanoparticles of 2-hydroxypropyl-β-cyclodextrin plus enhancers (trometamol and ethylenediaminetetraacetic acid) and UV-A irradiation with a 10 mW/cm2 device for 9 minutes...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28095050/the-expressions-of-klotho-family-genes-in-human-ocular-tissues-and-in-anterior-lens-capsules-of-age-related-cataract
#14
Yu Zhang, Liya Wang, Zhong Wu, Xiaolin Yu, Xiaofeng Du, Xiaohua Li
PURPOSE: Klotho genes are expressed in limited tissues and have been found to be a pathogenic factor of age-related diseases in mammals, but their expressions and functions in human eyes are yet to be defined. This study was performed to investigate the expression of Klotho family genes in human ocular tissues and anterior lens capsules of age-related cataract. METHODS: Individual tissues were isolated from human eyeballs collected from Henan Eye Bank. Human anterior lens capsules were collected from cortical cataract patients during phacoemulsification with the informed consent...
January 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28060143/comparison-of-hospital-cornea-retrieval-and-voluntary-eye-donation-program-in-eye-banking
#15
Namrata Sharma, Nikhil Agrawal, Prafulla K Maharana, Tushar Agarwal, Murugesan Vanathi, Rasik B Vajpayee
OBJECTIVES: Comparison of demographic, clinical, microbiological, and utility profile of the corneas obtained through hospital corneal retrieval program (HCRP) and voluntary eye donation (VED) program. METHODS: Donor corneas retrieved during a 14 months period at National eye bank, India were included in the study. The donor cornea grading was done according to the cornea donor study. The corneal swabs were taken from the donor eyes and were sent for microbiological evaluation...
January 4, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28060077/ethical-issues-in-transnational-eye-banking
#16
Dominique E Martin, Richard Kelly, Gary L A Jones, Heather Machin, Graeme A Pollock
PURPOSE: To review ethical issues that may arise in the setting of transnational eye banking activities, such as when exporting or importing corneal tissue for transplantation. METHODS: A principle-based normative analysis of potential common dilemmas in transnational eye banking activities was performed. RESULTS: Transnational activities in eye banking, like those in other fields involving procurement and use of medical products of human origin, may present a number of ethical issues for policy makers and professionals...
February 2017: Cornea
https://www.readbyqxmd.com/read/28055053/optical-coherence-tomography-based-topography-determination-of-corneal-grafts-in-eye-bank-cultivation
#17
Angela Damian, Berthold Seitz, Achim Langenbucher, Timo Eppig
No abstract text is available yet for this article.
January 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28033432/association-between-endothelial-cell-density-and-transplant-suitability-of-corneal-tissue-with-type-1-and-type-2-diabetes
#18
Jordan A Margo, Wuqaas M Munir, Clayton H Brown, Caroline K Hoover
Importance: The rate of types 1 and 2 diabetes in the United States is increasing. The effect of diabetes on corneal donor tissue is unknown. Objectives: To determine the association between endothelial cell density and suitability for transplantation in cornea donors with type 1 or 2 diabetes and determine the effect of diabetes on technician-induced endothelial damage during cornea donor tissue processing. Design, Setting, and Participants: Donor information was obtained from the SightLife Eye Bank for donors from June 1, 2012, to June 30, 2015...
December 29, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28002793/next-generation-sequencing-of-vitreoretinal-lymphomas-from-small-volume-intraocular-liquid-biopsies-new-routes-to-targeted-therapies
#19
Andi K Cani, Daniel H Hovelson, Hakan Demirci, Mark W Johnson, Scott A Tomlins, Rajesh C Rao
BACKGROUND: Vitreoretinal lymphoma (VRL), the most common lymphoma of the eye, is a rare form of primary CNS lymphoma (PCNSL). Most frequently a high-grade diffuse large B cell lymphoma, VRL can cause vision loss and its prognosis remains dismal: the overall survival time is 3 years after diagnosis. Radiotherapy and chemotherapy are used but remain frequently ineffective, and no standardized treatment regimen exists. Furthermore, no biologically targeted treatments, based on the genetic profile of the tumor, are available, as VRL has hitherto not comprehensively been profiled...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27984364/age-stratified-analysis-of-diabetes-and-pseudophakia-effects-on-corneal-endothelial-cell-density-a-retrospective-eye-bank-study
#20
Yicheng Chen, Sean W Tsao, Moonseong Heo, Patrick K Gore, Mitchell D McCarthy, Roy S Chuck, Prabjot Channa
PURPOSE: To perform an age-stratified analysis of the effect of diabetes and pseudophakia on corneal endothelial cell density (ECD). METHODS: This is a comparative analysis of donor characteristics from data supplied by the Lions Eye Institute for Transplant and Research on tissue harvested from July 1, 2007, through May 23, 2014. The mixed-effects model was used to compare age-adjusted mean corneal ECD between donors with and without diabetes. RESULTS: A total of 20,026 nondiabetic donor eyes and 13,617 diabetic donor eyes were included in this study...
March 2017: Cornea
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