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https://www.readbyqxmd.com/read/28542087/validity-of-postmortem-glycated-hemoglobin-to-determine-status-of-diabetes-mellitus-in-corneal-donors
#1
Mark C Soper, Santica M Marcovina, Caroline K Hoover, Peter M Calhoun, Kristen E McCoy, Christopher G Stoeger, Gregory A Schmidt, Baha M Arafah, Marianne O Price, Loretta B Szczotka-Flynn, Jonathan H Lass
PURPOSE: To examine the stability of postmortem glycated hemoglobin (HbA1c) measurement and its relationship to premortem glycemia. METHODS: Postmortem blood samples were obtained from 32 donors (8 known diabetic) and shipped on ice to a central laboratory to examine the stability of HbA1c measurements during the first 9 postmortem days. Thirty-nine other suspected diabetic donors underwent comparison of premortem and postmortem HbA1c measurements. RESULTS: Postmortem HbA1c measurements remained stable after 9 postmortem days (all measurements within ±0...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28535143/intercultural-communication-through-the-eyes-of-patients-experiences-and-preferences
#2
Emma Paternotte, Sandra van Dulmen, Lindsay Bank, Conny Seeleman, Albert Scherpbier, Fedde Scheele
Objectives: To explore patients' preferences and experiences regarding intercultural communication which could influence the development of intercultural patient-centred communication training. Methods: This qualitative study is based on interviews with non-native patients. Thirty non-native patients were interviewed between September and December 2015 about their preferences and experiences regarding communication with a native Dutch doctor. Fourteen interviews were established with an interpreter...
May 16, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28508165/frequency-of-toxoplasma-gondii-in-the-retina-in-eye-banks-in-brazil
#3
Deise F Costa, Heloisa Nascimento, Aline Sutili, Fernando A J Nobrega, Flavio Fowler, Mario Junqueira Nobrega, Cristina Garrido, Janaina de Oliveira Dias, Consuelo B D Adán, Luiz Vicente Rizzo, Claudio Silveira, Rubens Belfort, Alessandra G Commodaro
Ocular toxoplasmosis is the main cause of posterior uveitis worldwide frequently leading to vision loss. In Brazil, the seroprevalence of Toxoplasma gondii infection ranges from 50 to 80% depending of the region studied. The frequency of toxoplasmic retinal scar may reach 18% of the adults in the South of Brazil. Our goal was to determine the frequency of T. gondii DNA in retinas from eye banks from different regions in Brazil. A total of 162 eyes were obtained from eye banks in Manaus (n = 60), Sao Paulo (n = 60), Chapeco (n = 26), and Joinville (n = 16)...
May 15, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28495906/emergency-corneal-grafting-in-the-uk-a-6-year-analysis-of-the-uk-transplant-registry
#4
Parwez Hossain, Abdo Karim Tourkmani, Dimitri Kazakos, Mark Jones, David Anderson
BACKGROUND: Corneal graft (CG) surgery is the most common and successful tissue transplant worldwide. A small and important group of patients are operated in emergency situations, typically to save a perforated eye. Our knowledge of the indications and outcomes of emergency corneal graft (eCG) is limited. METHODS: Retrospective, multifactorial analysis of all CGs registered by the UK Transplant Service from April 1999 to March 2005. RESULTS: A total of 12 976 CGs were performed...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28489792/eye-bank-prepared-versus-surgeon-cut-endothelial-graft-tissue-for-descemet-membrane-endothelial-keratoplasty-an-observational-study
#5
Marie Regnier, Céline Auxenfans, Delphine Maucort-Boulch, Anne-Sophie Marty, Odile Damour, Carole Burillon, Viridiana Kocaba
The purpose of this article is to examine outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed with cornea bank (CB) prestripped tissue and surgeon stripped tissue (SST).This retrospective study examined subjects who underwent DMEK with CB or surgeon prepared tissue for Fuchs endothelial corneal dystrophy. Best-corrected visual acuity (BCVA), corneal thickness, endothelial cell count (ECC), and complications were examined before and throughout a 6-month postoperative period.Eleven CB and 22 SST subjects were included...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28469991/donor-transmitted-melanoma-after-limbal-stem-cell-transplantation
#6
Anas Alsara, Muhammad Rafi
Limbal Stem Cells are a unique cell line located at the corneal limbus. They are responsible for regenerating and restoring corneal epithelial layers. Limbal stem cell transplantation is a promising technique that has been used to treat several hereditary and acquired corneal diseases. Cornea tissue lack vascularity. Hence, there were no special restrictions on collecting ocular tissues from donors with a diagnosis of metastatic melanoma. We are reporting a case of a patient who developed an ocular melanoma after she had limbal stem cell transplantation from a donor with history of melanoma...
April 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28457284/corneal-surgery-in-the-flying-eye-hospital-characteristics-and-visual-outcome
#7
Javed Hussain Farooqui, Emile Sharifi, Ahmed Gomaa
OBJECTIVE: The Flying Eye Hospital (FEH) of ORBIS International is a capacity-building platform that trains ophthalmologists throughout the developing world on-board a fully functional eye hospital based in an airplane and in the local hospitals of developing countries. Corneal blindness (CB) is the second leading cause of blindness in most developing countries. Treatment of existing global CB requires effective eye banking and surgeons trained in corneal transplant. ORBIS International has programs that addressed both those needs...
April 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28450146/alternatives-to-eye-bank-native-tissue-for-corneal-stromal-replacement
#8
REVIEW
Isabelle Brunette, Cynthia J Roberts, François Vidal, Mona Harissi-Dagher, Jean Lachaine, Heather Sheardown, Georges M Durr, Stéphanie Proulx, May Griffith
Corneal blindness is a major cause of blindness in the world and corneal transplantation is the only widely accepted treatment to restore sight in these eyes. However, it is becoming increasingly difficult for eye banks to meet the increasing demand for transplantable tissue, which is in part due to population aging. Donor tissue shortage is therefore a growing concern globally and there is a need for alternatives to human donor corneas. Biosynthetic corneal substitutes offer several significant advantages over native corneas: Large-scale production offers a powerful potential solution to the severe shortage of human donor corneas worldwide; Good manufacturing practices ensure sterility and quality control; Acellular corneal substitutes circumvent immune rejection induced by allogeneic cells; Optical and biomechanical properties of the implants can be adapted to the clinical need; and finally these corneal substitutes could benefit from new advances in biomaterials science, such as surface coating, functionalization and nanoparticles...
April 24, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28446867/response-properties-of-motor-equivalence-neurons-of-the-primate-premotor-cortex
#9
Eleftherios Neromyliotis, A K Moschovakis
To study the response properties of cells that could participate in eye-hand coordination we trained two macaque monkeys to perform center-out saccades and pointing movements with their right or left forelimb toward visual targets presented on a video display. We analyzed the phasic movement related discharges of neurons of the periarcuate cortex that fire before and during saccades and movements of the hand whether accompanied by movements of the other effector or not. Because such cells could encode an abstract form of the desired displacement vector without regard to the effector that would execute the movement we refer to such cells as motor equivalence neurons (Meq)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28397149/considering-3d-topography-of-endothelial-folds-to-improve-cell-count-of-organ-cultured-corneas
#10
Clotilde Jumelle, Thibaud Garcin, Anne Sophie Gauthier, Yaël Glasson, Aurélien Bernard, Yann Gavet, Jacques Klossa, Zhiguo He, Sophie Acquart, Philippe Gain, Gilles Thuret
The posterior side of the cornea is covered by the endothelial monolayer, which governs corneal transparency but cannot proliferate. Determination of endothelial cell density (ECD) is therefore the minimal and mandatory quality control in all eye banks. It avoids primary graft failures caused by endothelial insufficiency, and allows allocation of corneas to surgical techniques requiring different numbers of endothelial cells (ECs). Corneas stored in organ culture (17% of grafts worldwide), are characterized by heavy stromal swelling and numerous deep endothelial folds, up to 200 µm high...
June 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28381247/outcomes-of-descemet-stripping-automated-endothelial-keratoplasty-using-imported-donor-corneas
#11
Kaevalin Lekhanont, Kavin Vanikieti, Nutthida Nimvorapun, Varintorn Chuckpaiwong
BACKGROUND: The lack of development of local donor tissue acquisition in several regions of the world has resulted in the necessity of performing keratoplasty with imported donor corneas. The greatest concern about the use of donor corneas supplied by foreign eye banks is the effect of the increased donor death-to-operation time which inevitably occurs during the tissue recovery, tissue processing, and tissue transfer between the countries. The purpose of this study was to report the outcomes of descemet stripping automated endothelial keratoplasty (DSAEK) using imported donor corneas...
April 5, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28378499/autologous-cord-blood-infusions-are-safe-and-feasible-in-young-children-with-autism-spectrum-disorder-results-of-a-single-center-phase-i-open-label-trial
#12
Geraldine Dawson, Jessica M Sun, Katherine S Davlantis, Michael Murias, Lauren Franz, Jesse Troy, Ryan Simmons, Maura Sabatos-DeVito, Rebecca Durham, Joanne Kurtzberg
Despite advances in early diagnosis and behavioral therapies, more effective treatments for children with autism spectrum disorder (ASD) are needed. We hypothesized that umbilical cord blood-derived cell therapies may have potential in alleviating ASD symptoms by modulating inflammatory processes in the brain. Accordingly, we conducted a phase I, open-label trial to assess the safety and feasibility of a single intravenous infusion of autologous umbilical cord blood, as well as sensitivity to change in several ASD assessment tools, to determine suitable endpoints for future trials...
May 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28374155/morphometry-of-organ-cultured-corneal-endothelium-using-voronoi-segmentation
#13
Nigel H Brookes
The endothelial viability of eye-banked corneas must be assessed before transplantation, yet phase-contrast images of the endothelium of corneas stored in an Organ Culture system have a huge variety of endothelial appearance at different focal planes, due to stromal swelling and an evaluation technique that swells the cells and their intercellular spaces to make them visible. This makes them difficult to assess using common edge-based segmentation methodologies that have mostly been developed in vivo using specular microscopy...
June 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28370795/a-pair-of-glasses-and-beyond-impact-of-refractive-error-on-people-s-well-being
#14
Himal Kandel, Jyoti Khadka, Michael Goggin, Konrad Pesudovs
IMPORTANCE: This study qualitative explores the impact of refractive error on adults, particularly after correction. BACKGROUND: The study aimed to explore the impact of refractive error on people's quality of life. DESIGN: Cross sectional; In-depth telephone and face-to-face semi-structured interviews; Qualitative study with inductive and deductive processes PARTICIPANTS: 48 adults with refractive error (including presbyopia) were recruited from the Flinders Vision, the Ashford Advanced Eye Care and among Flinders University staff and students, in South Australia...
March 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28362137/magnitude-and-determinants-of-the-ratio-between-prevalence-of-low-vision-and-blindness-in-rapid-assessment-of-avoidable-blindness-surveys
#15
Dinesh Kaphle, Susan Lewallen
PURPOSE: To determine the magnitude and determinants of the ratio between prevalence of low vision and prevalence of blindness in rapid assessment of avoidable blindness (RAAB) surveys globally. METHODS: Standard RAAB reports were downloaded from the repository or requested from principal investigators. Potential predictor variables included prevalence of uncorrected refractive error (URE) as well as gross domestic product (GDP) per capita, health expenditure per capita of the country across World Bank regions...
March 31, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28348631/optic-neuropathy-as-the-initial-presenting-sign-of-n-methyl-d-aspartate-nmda-encephalitis
#16
Mark Mugavin, Brett H Mueller, Masoom Desai, Karl C Golnik
A 52-year-old woman presented with painless vision loss for 3 months. She was in custody for allegedly robbing a bank and had recently been diagnosed with paranoid schizophrenia. She had 20/100 VA OD, a 2+RAPD, and optic atrophy. Extensive diagnostic workup including MRI, Fluorescein Angiography, Infectious Disease Panel, lumbar puncture, and leptomeningeal biopsy were unrevealing. Vision in her right eye declined to NLP and her left eye declined to 20/200 VA. Anti N-methyl-D-aspartate (NMDA) Autoimmune Encephalitis was diagnosed based on CSF serology and clinical suspicion...
April 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28345565/upgradation-and-modernization-of-eye-banking-services-integrating-tradition-with-innovative-policies-and-current-best-practices
#17
Radhika Tandon, Archita Singh, Noopur Gupta, M Vanathi, Vivek Gupta
PURPOSE: The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources. METHODS: Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28335564/passage-through-the-ocular-barriers-and-beneficial-effects-in-retinal-ischemia-of-topical-application-of-pacap1-38-in-rodents
#18
Dora Werling, William A Banks, Therese S Salameh, Timea Kvarik, Laszlo Akos Kovacs, Alexandra Vaczy, Edina Szabo, Flora Mayer, Rita Varga, Andrea Tamas, Gabor Toth, Zsolt Biro, Tamas Atlasz, Dora Reglodi
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has two active forms, PACAP1-27 and PACAP1-38. Among the well-established actions are PACAP's neurotrophic and neuroprotective effects, which have also been proven in models of different retinopathies. The route of delivery is usually intravitreal in studies proving PACAP's retinoprotective effects. Recently, we have shown that PACAP1-27 delivered as eye drops in benzalkonium-chloride was able to cross the ocular barriers and exert retinoprotection in ischemia...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28317856/a-smartphone-based-diagnostic-platform-for-rapid-detection-of-zika-chikungunya-and-dengue-viruses
#19
Aashish Priye, Sara W Bird, Yooli K Light, Cameron S Ball, Oscar A Negrete, Robert J Meagher
Current multiplexed diagnostics for Zika, dengue, and chikungunya viruses are situated outside the intersection of affordability, high performance, and suitability for use at the point-of-care in resource-limited settings. Consequently, insufficient diagnostic capabilities are a key limitation facing current Zika outbreak management strategies. Here we demonstrate highly sensitive and specific detection of Zika, chikungunya, and dengue viruses by coupling reverse-transcription loop-mediated isothermal amplification (RT-LAMP) with our recently developed quenching of unincorporated amplification signal reporters (QUASR) technique...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317665/preparation-of-ultrathin-grafts-for-descemet-stripping-endothelial-keratoplasty-with-a-single-microkeratome%C3%A2-pass
#20
Vito Romano, Bernhard Steger, Jayavani Myneni, Mark Batterbury, Colin E Willoughby, Stephen B Kaye
We present a technique to achieve ultrathin Descemet-stripping automated endothelial keratoplasty (DSAEK). Using a simple method of controlling artificial anterior chamber pressure and drying the corneal surface, it was possible to thin the donor cornea at a rate of 11 μm a minute. When the donor cornea was between 500 μm and 510 μm, a single pass was made using a 350 μm microkeratome head followed by a peripheral dissection. The resulting mean graft thickness was 83.2 μm ± 14.9 (SD) (range 50 to 98 μm) with a mean peripheral graft edge thickness of 106...
January 2017: Journal of Cataract and Refractive Surgery
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