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Corneal endothelium

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https://www.readbyqxmd.com/read/28630766/corneal-endothelial-characteristics-central-corneal-thickness-and-intraocular-pressure-in-a-population-of-chinese-age-related-cataract-patients
#1
Yingmei Li, Zhentao Fu, Jian Liu, Miao Li, Yuguang Zhang, Xinyi Wu
PURPOSE: To describe corneal endothelial characteristics, central corneal thickness, and intraocular pressure in a population of Chinese age-related cataract patients and to determine the effects of age, gender, hypertension, and body mass index (BMI). METHODS: 1551 eyes were examined preoperatively. The parameters measured were endothelial cell density (CD), average cell area (CA), coefficient of variation (CV), cell hexagonality (HEX), central corneal thickness (CCT), intraocular pressure (IOP), and axial length (AL)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28623474/epithelial-fluid-transport-is-due-to-electro-osmosis-80-plus-osmosis-20
#2
Jorge Fischbarg, Julio A Hernandez, Andrey A Rubashkin, Pavel Iserovich, Veronica I Cacace, Carlos F Kusnier
Epithelial fluid transport, an important physiological process shrouded in a long-standing enigma, may finally be moving closer to a solution. We propose that, for the corneal endothelium, relative proportions for the driving forces for fluid transport are 80% of paracellular electro-osmosis, and 20% classical transcellular osmosis. These operate in a cyclical process with a period of 9.2 s, which is dictated by the decrease and exhaustion of cellular Na(+). Paracellular electro-osmosis is sketched here, and partially discussed as much as the subject still allows; transcellular osmosis is presented at length...
June 16, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28619506/near-infra-red-light-attenuates-corneal-endothelial-cell-dysfunction-in-situ-and-in%C3%A2-vitro
#3
Claudia Núñez-Álvarez, Susana Del Olmo-Aguado, Jesús Merayo-Lloves, Neville N Osborne
In the present study mechanical damage to the corneal endothelium was induced by elevation of intraocular pressure (IOP, 140 mmHg, 60 min) to one eye of rats, delivered either in complete darkness or in the presence of red light (16.5 W/m(2), 3000 lx, 625-635 nm). IOP raised in the dark revealed the endothelium to be damaged as staining for the gap junction protein ZO-1 was irregular in appearance with some cells displaced in position or lost to leave gaps or holes. This damage was clearly attenuated when red light was focused through the pupil during the insult of raised IOP...
June 13, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28614429/clinical-and-epidemiological-aspects-of-cornea-transplant-patients-of-a-reference-hospital
#4
Giovanna Karinny Pereira Cruz, Isabelle Campos de Azevedo, Diana Paula de Souza Rego Pinto Carvalho, Allyne Fortes Vitor, Viviane Euzébia Pereira Santos, Marcos Antonio Ferreira
Objective: clinically characterizing cornea transplant patients and their distribution according to indicated and post-operative conditions of cornea transplantation, as well as estimating the average waiting time. Method: a cross-sectional, descriptive and analytical study performed for all cornea transplants performed at a reference service (n=258). Data were analyzed using Statistical Package for the Social Sciences, version 20.0. Results: the main indicator for cornea transplant was keratoconus...
June 8, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28614153/further-analysis-of-the-predictability-of-corneal-endothelial-cell-density-estimates-when-polymegethism-is-present
#5
Michael J Doughty
PURPOSE: To assess variability in endothelial cell density (ECD) estimates when polymegethism (variance in cell areas) is present. METHODS: Using noncontact specular microscope images of the corneal endothelium, 4 sets of 20 cases were selected, which included 200 cells and had coefficient of variation values of less than 30% (group 1), 31%-40% (group 2), 41%-50% (group 3), and over 50% (group 4). A stepwise analysis was undertaken, 20 cells at a time, of the ECD estimates when using different numbers of cells for the calculations...
June 13, 2017: Cornea
https://www.readbyqxmd.com/read/28608272/ctg18-1-repeat-expansion-may-reduce-tcf4-gene-expression-in-corneal-endothelial-cells-of-german-patients-with-fuchs-dystrophy
#6
Sabine Foja, Mirjam Luther, Katrin Hoffmann, Andreas Rupprecht, Claudia Gruenauer-Kloevekorn
PURPOSE: It was the aim of this investigation to elucidate the functional effects of CTG18.1 trinucleotide repeat expansion and the polymorphism rs613872 in the transcription factor 4 (TCF4) in corneas of patients affected by Fuchs' endothelial corneal dystrophy (FECD). METHODS: Sixty-one unrelated German patients with FECD and 113 unaffected controls were investigated and genotyped for the CTG18.1 locus by triplet primed PCR (TP-PCR) and the rs613872 polymorphism via Sanger sequencing and by employing genomic DNA from peripheral blood leucocytes...
June 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28602331/ocular-tolerance-in-rabbits-after-intracameral-administration-of-a-fixed-combination-of-tropicamide-phenylephrine-and-lidocaine-with-and-without-rinsing
#7
Rudy M M A Nuijts, Rita Mencucci, Karen Viaud-Quentric, Pierre-Paul Elena, Céline Olmière, Anders Behndig
PURPOSE: To evaluate the safety and tolerability of a single intracameral administration of a combined mydriatic (tropicamide and phenylephrine) and anesthetic (lidocaine) formulation (Mydrane) with or without rinsing. SETTING: Iris Pharma, La Gaude, France. DESIGN: Experimental study. METHODS: Sixty pigmented rabbits received 100 μL or 200 μL of the combination product or a placebo (sodium chloride 0.9%) by intracameral injection...
May 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28601345/comparison-of-12-month-anatomic-and-functional-results-between-z6-femtosecond-laser-assisted-and-manual-trephination-in-deep-anterior-lamellar-keratoplasty-for-advanced-keratoconus
#8
A Blériot, E Martin, P Lebranchu, K Zimmerman, L Libeau, M Weber, B Vabres, I Orignac
The management of severe keratoconus requires corneal transplantation, for which the gold standard is deep anterior lamellar keratoplasty (DALK), preserving the healthy Descemet's membrane and endothelium. The safety and reproducibility of corneal cuts have been improved by the evolution of femtosecond lasers in refractive surgery, and femtosecond laser in DALK would seem to provide the same advantages over the manual method. In our retrospective study, we compare functional and anatomical results of femtosecond-assisted DALK versus manual trephination DALK in patients with keratoconus in stage 4 of the Krumeich classification...
June 7, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28597601/endothelial-alterations-in-712-keratoconus-patients
#9
Susanne Goebels, Timo Eppig, Berthold Seitz, Nòra Szentmàry, Alan Cayless, Achim Langenbucher
PURPOSE: To investigate the effect of the severity of keratoconus on the corneal endothelium using specular microscopy. METHODS: Seven hundred and twelve eyes from the Homburg Keratoconus Center (HKC) database were included in this retrospective study. Corneal endothelium was evaluated using the Tomey EM-3000 specular microscope. Keratoconus-related topographic and tomographic data were obtained from Scheimpflug-based tomography (Oculus Pentacam(®) HR). Eyes were classified into stages 0 (healthy) to 4 (severe keratoconus) according to the Topographic Keratoconus Classification (TKC)...
June 9, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28594699/solitary-iris-plasmacytoma-with-anterior-chamber-crystalline-deposits
#10
Andrew W Stacey, Alenka Lavric, Caroline Thaung, Samreen Siddiq, Mandeep S Sagoo
PURPOSE: To report a case of solitary iris plasmacytoma successfully treated with ruthenium plaque radiotherapy. METHODS: A 44-year-old white woman presented with pain in the right eye and raised intraocular pressure. Her medical history included breast cancer treated 11 years earlier with lumpectomy, lymph node clearance, chemotherapy, and radiotherapy. On examination, the right iris had a tan-colored mass with crystalline deposits visible on the mass surface and on the corneal endothelium...
July 2017: Cornea
https://www.readbyqxmd.com/read/28549842/mitochondrial-dysfunction-and-oxidative-stress-in-corneal-disease
#11
Neeru A Vallabh, Vito Romano, Colin E Willoughby
The cornea is the anterior transparent surface and the main refracting structure of the eye. Mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of inherited (e.g. Kearns Sayre Syndrome) and acquired corneal diseases (e.g. keratoconus and Fuchs endothelial corneal dystrophy). Both antioxidants and reactive oxygen species are found in the healthy cornea. There is increasing evidence of imbalance in the oxidative balance and mitochondrial function in the cornea in disease states...
May 23, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28529272/congenital-anterior-staphyloma-associated-with-peters-anomaly-and-aphakia-in-a-holstein-calf
#12
Reiichiro Sato, Ken Onda, Masaru Murakami, Daiya Ito, Hiroo Madarame
A Holstein calf was born with a large protruding right eye and a central corneal opacity. Enucleation was the first choice of treatment. The calf had a good prognosis and was raised for milking purposes. Macroscopically, the enucleated eye was characterized by the protruded cornea, adherence of the iris to the central posterior cornea and aphakia. Microscopically, central corneal thickening and a defect in the endothelium and Descemet's membrane were observed. These data suggest that this represents a case of unilateral anterior segment dysgenesis consistent with congenital corneal staphyloma with Peters' anomaly and aphakia...
May 22, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28525682/secondary-sulcus-fixed-foldable-iol-implantation-with-25-g-infusion-in-patients-with-previous-ppv-after-open-globe-injury
#13
Tiangeng He, Caiyun You, Song Chen, Xiangda Meng, Yuanyuan Liu, Hua Yan
PURPOSE: To evaluate the safety and efficacy of secondary sulcus-fixed foldable intraocular lens (IOL) implantation through a clear corneal incision with 25-G infusion in patients with previous pars plana vitrectomy (PPV) after open-globe injury, and to analyze postoperative outcomes and prognostic factors of treatment. METHODS: Clinical data of 89 eyes of 89 patients with open-globe injury who underwent secondary sulcus-fixed foldable IOL implantation through a clear corneal incision with 25-G infusion after vitrectomy in our hospital between January 2008 and June 2015 were retrospectively analyzed...
May 16, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28509328/anatomy-based-dmek-wetlab-in-homburg-saar-novel-aspects-of-donor-preparation-and-host-maneuvers-to-teach-descemet-membrane-endothelial-keratoplasty
#14
B Seitz, L Daas, M Bischoff-Jung, N Szentmáry, S Suffo, M El-Husseiny, A Viestenz, G Milioti
INTRODUCTION: Use of Descemet Membrane Endothelial Keratoplasty (DMEK) has been limited because of problems with donor preparation, i.e. tearing of the Descemet membrane and difficulties in unfolding the Endothelium-Descemet-Membrane-Layer (EDML) in the anterior chamber (AC). The purpose of this work was to describe a novel approach to teaching anatomy-based donor and recipient preparation in a DMEK-Wetlab. MATERIAL AND METHODS: We teach successful mono-manual donor preparation of human corneas in organ culture not suitable for transplantation, including peripheral markers for orientation...
May 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28506643/epithelial-basement-membrane-injury-and-regeneration-modulates-corneal-fibrosis-after-pseudomonas-corneal-ulcers-in-rabbits
#15
Gustavo K Marino, Marcony R Santhiago, Abirami Santhanam, Luciana Lassance, Shanmugapriya Thangavadivel, Carla S Medeiros, Karthikeyan Bose, Kwai Ping Tam, Steven E Wilson
The purpose of this study was to investigate whether myofibroblast-related fibrosis (scarring) after microbial keratitis was modulated by the epithelial basement membrane (EBM) injury and regeneration. Rabbits were infected with Pseudomonas aeruginosa after epithelial scrape injury and the resultant severe keratitis was treated with topical tobramycin. Corneas were analyzed from one to four months after keratitis with slit lamp photos, immunohistochemistry for alpha-smooth muscle actin (α-SMA) and monocyte lineage marker CD11b, and transmission electron microscopy...
May 13, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28505675/-anti-lymph-angiogenic-strategies-to-improve-corneal-graft-survival
#16
Felix Bock, Claus Cursiefen
Corneal transplantation (keratoplasty) is the most frequently performed form of transplantation worldwide. A rejection reaction against the transplant is the main complication occurring after transplantation in an already vascularized, so-called "high-risk" recipient eye. Our group has shown that clinically invisible lymphatic vessels play a crucial role in the induction of a rejection reaction against the corneal graft, and that anti-(lymph)angiogenic therapies in the mouse model of keratoplasty can significantly improve transplant survival...
May 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28480600/ophthalmic-parameters-in-adult-lowland-paca-cuniculus-paca-raised-in-captivity
#17
Camila P Balthazar da Silveira, Tiago B Lima, Roberta M Crivelaro, Luciana C C de Lacerda, Ivan R M Pádua, Roberta Renzo, Alexandre A F de Barros Sobrinho, Fabrício S Oliveira, Marcela Aldrovani, José L Laus
OBJECTIVE: To investigate the ophthalmic parameters of lowland pacas, including the anatomic features, tear production, intraocular pressure, central corneal thickness, and morphology of the corneal endothelium. ANIMALS STUDIED: Thirteen adult, anesthetized Cuniculus paca. PROCEDURE: Eyes were evaluated using slit-lamp biomicroscopy, the Schirmer tear test I, digital applanation tonometry, binocular indirect ophthalmoscopy, and noncontact specular microscopy...
May 8, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28479036/-descemet-s-membrane-endothelial-keratoplasty-dmek-analysis-of-a-variation-in-descemet-s-endothelial-graft-preparation
#18
C Benoist D'azy, C Benoist D'azy, E Gabison, V Sapin, C Bosc, B Pereira, F Chiambaretta
INTRODUCTION: Descemet's membrane endothelial keratoplasty (DMEK) can replace just the corneal endothelium and respect the natural corneal anatomy. Currently, the technique of endothelial graft preparation remains manual and non-standardized. PURPOSE: To report anatomic and functional results after DMEK, and compare two techniques of graft preparation. METHODS: Single-center retrospective study, including 64 eyes of 64 patients undergoing DMEK, from September 2014 to February 2016 at Clermont-Ferrand University Medical Center...
May 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28465835/a-rabbit-model-study-to-determine-the-efficacy-of-a-prototype-corneal-endothelium-protector-during-cataract-surgery
#19
Annabel C Y Chew, Anita Chan, Monisha E Nongpiur, Gary Peh, Veluchamy A Barathi, Nyein C Lwin, Charles Ong, Shamira Perera
Purpose. We evaluated the efficacy and safety of a mechanical device, the P-chute, in corneal endothelium preservation during phacoemulsification in a rabbit model. Methods. Twenty-four rabbits were randomly assigned into 2 groups. One eye of each rabbit underwent phacoemulsification that simulated the removal of a dense nucleus, with or without the P-chute. Serial slit-lamp examinations, anterior segment optical coherence tomography (ASOCT) scans, and specular microscopy were performed. Three rabbits from each group were sacrificed on postoperative days (PODs) 1, 5, 7, and 14...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28465186/expansion-and-cryopreservation-of-porcine-and-human-corneal-endothelial-cells
#20
Leah A Marquez-Curtis, Locksley E McGann, Janet A W Elliott
Impairment of the corneal endothelium causes blindness that afflicts millions worldwide and constitutes the most often cited indication for corneal transplants. The scarcity of donor corneas has prompted the alternative use of tissue-engineered grafts which requires the ex vivo expansion and cryopreservation of corneal endothelial cells. The aims of this study are to culture and identify the conditions that will yield viable and functional corneal endothelial cells after cryopreservation. Previously, using human umbilical vein endothelial cells (HUVECs), we employed a systematic approach to optimize the post-thaw recovery of cells with high membrane integrity and functionality...
April 29, 2017: Cryobiology
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