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Corneal endothelium

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https://www.readbyqxmd.com/read/29046048/bone-morphogenetic-protein-4-and-bone-morphogenetic-protein-receptors-expressions-in-the-adult-rat-eye
#1
Yuka Maruyama-Koide, Sumiko Mikawa, Takeshi Sasaki, Kohji Sato
We investigated the expressions of bone morphogenetic protein-4 (BMP4) and its receptors, bone morphogenetic protein receptor IA (BMPRIA), bone morphogenetic protein receptor IB (BMPRIB) and bone morphogenetic protein receptor II (BMPRII) in the adult rat eye. Interesting differences in expression profile were observed between BMPRIA and BMPRIB in the retina. BMPRIA-like immunoreactivity (IR) was very intensely seen in the photoreceptor layer, while BMPRIB-IR was mainly observed in the other layers. In the cornea, BMP4, BMPRIA, BMPRIB and BMPRII-IRs were abundantly seen in the cell body of basal cells in the corneal epithelium, and endothelium...
September 6, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29044056/association-of-polymorphisms-in-the-intron-of-tcf4-gene-to-late-onset-fuchs-endothelial-corneal-dystrophy-an-indian-cohort-study
#2
Bhavna S Rao, Arokiasamy Tharigopala, Sudhir R Rachapalli, Rama Rajagopal, Nagasamy Soumittra
PURPOSE: Fuchs endothelial corneal dystrophy (FECD) is a progressive degenerative disease of the corneal endothelium. It is genetically heterogeneous and follows either an autosomal dominant or sporadic pattern of inheritance. Here, we have explored the association of four previously reported intronic single nucleotide polymorphisms and intronic CTG repeat expansions in TCF4 gene to FECD in an Indian cohort. METHODS: The cohort consisting of 52 sporadic late-onset cases, 5 early-onset cases, and 148 controls was taken for the study...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043524/improving-the-success-rate-of-human-corneal-endothelial-cell-cultures-from-single-donor-corneas-with-stabilization-medium
#3
D Spinozzi, A Miron, M Bruinsma, J T Lie, I Dapena, S Oellerich, G R J Melles
Main objective of this study was to improve the success rate of human corneal endothelial cell (hCEC) cultures from single donor corneas. We could show that the use of stabilization medium prior to cell isolation may have a positive effect on the success rate of hCEC cultures from single research-grade donor corneas by allowing growth of otherwise possibly not successful cultures and by improving their proliferative rate. hCEC were obtained from corneo-scleral rims of 7 discarded human research-grade cornea pairs...
October 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29030797/corneal-endothelial-changes-following-a-single-session-of-selective-laser-trabeculoplasty-for-pseudoexfoliative-glaucoma
#4
Nurgül Örnek, Kemal Örnek
PURPOSE: To evaluate corneal endothelial cell parameters after a single session of selective laser trabeculoplasty (SLT) in pseudoexfoliative glaucoma (PEG) patients. METHODS: Corneal endothelial cell parameters of 18 PEG patients were compared with 18 healthy subjects following SLT treatment. All patients underwent SLT treatment to 180 degrees of inferior trabecular meshwork. Corneal measurements were performed using specular microscopy (Noncon Robo SP8000, Konan Medical, Hyogo, Japan)...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29026787/factors-determining-effective-orthokeratology-treatment-for-controlling-juvenile-myopia-progression
#5
Qinghui Kong, Jiang Guo, Jing Zhou, Yanling Zhang, Xiaoyan Dou
BACKGROUND: We aimed to identify factors influencing the therapeutic outcome of orthokeratology on controlling juvenile myopia progression, and the risk factors for complications. METHODS: Myopic patients (n=724) in Shenzhen Second Hospital from Jan 2011 to Jan 2016 fitted with orthokeratology lenses and followed-up for 6-65 months were reviewed retrospectively. Univariate and multivariate logistic regression analyses were used to screen for the factors that can improve treatment outcome and prevent the development of complications...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29022958/unilateral-lattice-corneal-dystrophy-in-a-young-female-a-unique-case-report
#6
Anuradha Raj, Renu Dhasmana, Harsh Bahadur
BACKGROUND: Unilateral lattice corneal dystrophy is a rare entity. OBJECTIVE: To highlight the evidence of unilateral lattice corneal dystrophy in a young female. CASE: A young 28 years old female presented to the outpatient department of Ophthalmology with slowly progressive diminution of vision in left eye for one month. On ophthalmological examination best corrected visual acuity (BCVA) was 20/20 and 20/40 with refractive error of plano and -0...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29022296/efficacy-and-safety-of-intracameral-bevacizumab-for-treatment-of-neovascular-glaucoma
#7
Jun Young Ha, Tae Hee Lee, Mi Sun Sung, Sang Woo Park
PURPOSE: To evaluate the long-term efficacy and safety of intracameral bevacizumab in patients with neovascular glaucoma. METHODS: This retrospective study included 26 eyes of 26 neovascular glaucoma patients who received intracameral bevacizumab injection between January 2013 and May 2015, and were followed-up for at least 1 year. All patients were treated with topical and/or systemic intraocular pressure (IOP)-lowering medications, intracameral bevacizumab, and panretinal photocoagulation (PRP)...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28993974/unique-variations-and-characteristics-of-iridocorneal-endothelial-syndrome-in-china-a-case-series-of-58-patients
#8
Bo Feng, Xin Tang, Hong Chen, Xia Sun, Ningli Wang
PURPOSE: Iridocorneal endothelial (ICE) syndrome is a rare condition, and unique characteristics in Chinese patients can make diagnosis difficult. Our purpose was to describe the clinical characteristics and variations of ICE syndrome in 58 consecutive Chinese patients. METHODS: The clinical data of consecutive patients with ICE syndrome who were seen between 2008 and 2011 at the glaucoma clinic of our ophthalmology department were retrospectively reviewed. The diagnostic criteria for ICE syndrome were a "hammered-silver" appearance of the corneal endothelium and specular microscopy showing ICE cells characterized by the absence of a hexagonal appearance, dark areas within the cells, and a light-dark reversal pattern...
October 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28991612/long-term-safety-follow-up-of-an-anterior-chamber-angle-supported-phakic-intraocular-lens
#9
Thomas Kohnen, Laura LaFontaine, Russell Andrew
PURPOSE: To report adverse device effects and annualized endothelial cell loss rate for up to 10 years after implantation of the Acrysof L-series Cachet phakic intraocular lens (pIOL). SETTING: Clinical centers in the United States, European Union, and Canada. DESIGN: Nonrandomized clinical trial. METHODS: After implantation of the pIOL, the endothelial cell density (ECD) at follow-up evaluations was compared with the 6-month postoperative baseline...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28982949/the-existence-of-dead-cells-in-donor-corneal-endothelium-preserved-with-storage-media
#10
Koji Kitazawa, Tsutomu Inatomi, Hidetoshi Tanioka, Satoshi Kawasaki, Hiroko Nakagawa, Osamu Hieda, Hideki Fukuoka, Naoki Okumura, Noriko Koizumi, Bernie Iliakis, Chie Sotozono, Shigeru Kinoshita
AIM: To investigate the viability of donor corneal endothelial cells (CECs) preserved in storage media by histological examination. METHODS: Twenty-eight donor corneas were obtained from SightLife Eye Bank (Seattle, Washington), and redundant peripheral portions of those corneas were used for histological examination after removal of the centre corneal graft for transplantation. To assess cell viability in the corneal endothelium, biostaining experiments were performed using propidium iodide, calcein-AM, Hoechst 33 342, annexin V, anti-vimentin antibody and toluidine blue...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28981549/retinal-pathology-in-the-ppcd1-mouse
#11
Anna L Shen, Susan M Moran, Edward A Glover, Leandro B Teixeira, Christopher A Bradfield
Retinal phenotypes of the PPCD1 mouse, a mouse model of posterior polymorphous corneal dystrophy, have been characterized. PPCD1 mice on the DBA/2J background (D2.Ppcd1) have previously been reported to develop an enlarged anterior chamber due to epithelialization and proliferation of the corneal endothelium and subsequent blockage of the iridocorneal angle. Results presented here show that D2.Ppcd1 mice develop increased intraocular pressure (IOP), with measurements at three months of age revealing significant increases in IOP...
2017: PloS One
https://www.readbyqxmd.com/read/28963702/in-vivo-confocal-laser-microscopy-of-morphologic-changes-after-small-incision-lenticule-extraction-with-accelerated-cross-linking-smile-xtra-in-patients-with-thin-corneas-and-high-myopia
#12
Yugui Zhou, Manli Liu, Ting Zhang, Hua Zheng, Yuan Sun, Xiaonan Yang, Shengbei Weng, Haiqin Lin, Quan Liu
PURPOSE: To evaluate the microstructural modifications and safety of small incision lenticule extraction combined with accelerated cross-linking (SMILE Xtra) in high myopia and thin corneas by means of in vivo confocal microscopy (IVCM) and 3D-OCT after a 6-month follow-up. METHODS: Forty-three eyes with high myopia and thin corneas were enrolled. All eyes underwent SMILE procedure. After the lenticule was extracted, 0.25% riboflavin was injected into the interface and allowed to diffuse for 60 s...
September 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28941176/optimized-human-platelet-lysate-as-novel-basis-for-a-serum-xeno-and-additive-free-corneal-endothelial-cell-and-tissue-culture
#13
Daniel Thieme, Lynn Reuland, Toni Lindl, Friedrich Kruse, Thomas Fuchsluger
INTRODUCTION: The expansion of donor derived corneal endothelial cells is a promising approach for regenerative therapies in corneal diseases. To achieve the best GMP standard the entire cultivation process should be devoid of non-human components. However, so far there is no suitable xeno-free protocol for clinical applications. METHODS: We therefore introduce a processed variant of a platelet lysate for the use in corneal cell and tissue culture based on a GMP-grade thrombocyte concentrate...
September 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28939367/comparison-of-three-human-platelet-lysates-used-as-supplements-for-in-vitro-expansion-of-corneal-endothelium-cells
#14
Tsung-Jen Wang, Ming-Sheng Chen, Ming-Li Chou, Hsiu-Chen Lin, Jerard Seghatchian, Thierry Burnouf
BACKGROUND: Human platelet lysates (HPLs) are emerging as the new gold standard supplement of growth media for ex vivo expansion of cells for transplant. However, variations do exist in the way how HPLs are prepared. In particular, uncertainties still exist regarding the type of HPL most suitable for corneal endothelium cells (CEC) expansion, especially as these cells have limited proliferative capacity. MATERIAL AND METHODS: Three distinct HPL preparations were produced, with or without calcium chloride/glass beads activation, and with or without heat treatment at 56°C for 30min...
August 31, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28936480/the-role-of-corneal-stroma-a-potential-nutritional-source-for-the-cornea
#15
Lingling Zhang, Matthew C Anderson, Chia-Yang Liu
Corneal stroma plays a pivotal role in normal visual function. Anatomically, it is located between the outer epithelium and the inner endothelium and is the thickest layer of the cornea. Keratocytes in the stroma produce a variety of cellular products, including growth factors/cytokines, extracellular matrix (ECM) components, and kinases. These products support normal corneal development and homeostasis.
August 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28936050/comparative-evaluation-of-corneal-endothelium-in-patients-with-diabetes-undergoing-phacoemulsification
#16
COMPARATIVE STUDY
Pramod K Sahu, Gopal K Das, Sumeet Agrawal, Sabitabh Kumar
PURPOSE: The purpose of this study is to determine if phacoemulsification with posterior chamber foldable intraocular lens implantation has a greater impact on the corneal endothelium of type 2 diabetic patients as compared to nondiabetic controls. MATERIALS AND METHODS: This study compared the corneal endothelial status in sixty patients with diabetes with good glycemic control and sixty nondiabetic controls before and after (1 week, 1 month, 2 month, and 3 month) uneventful phacoemulsification...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28934248/vps35-deficiency-impairs-slc4a11-trafficking-and-promotes-corneal-dystrophy
#17
Wei Liu, Fu-Lei Tang, Sen Lin, Kai Zhao, Lin Mei, Jian Ye, Wen-Cheng Xiong
Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD). However, Vps35/retromer's function in the eye or the contribution of Vps35-deficiency to eye degenerative disorders remains to be explored. Here we provide evidence for a critical role of Vps35 in mouse corneal dystrophy. Vps35 is expressed in mouse and human cornea...
2017: PloS One
https://www.readbyqxmd.com/read/28928909/transplanting-embryonic-stem-cells-onto-damaged-human-corneal-endothelium
#18
Charles Hanson, Arsaell Arnarsson, Thorir Hardarson, Ann Lindgård, Mandana Daneshvarnaeini, Catarina Ellerström, Anita Bruun, Ulf Stenevi
AIM: To investigate whether human embryonic stem cells (hESCs) could be made to attach, grow and differentiate on a human Descemet's membrane (DM). METHODS: Spontaneously differentiated hESCs were transferred onto a human corneal button with the endothelial layer removed using ocular sticks. The cells were cultured on a DM for up to 15 d. The genetically engineered hESC line expressed green fluorescent protein, which facilitated identification during the culture experiments, tissue preparation, and analysis...
August 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28922331/descemet-membrane-thickening-as-a-sign-for-the-diagnosis-of-corneal-graft-rejection-an-ex-vivo-study
#19
Ryan VanDenBerg, Vasilios F Diakonis, Alison Bozung, Gustavo Rosa Gameiro, Oliver Fischer, Ahmed El Dakkak, Jan Paul Ulloa-Padilla, Apostolos Anagnostopoulos, Sander Dubovy, Mohamed Abou Shousha
PURPOSE: To disclose, using an ex vivo study, the histopathological mechanism behind in vivo thickening of the endothelium/Descemet membrane complex (En/DM) observed in rejected corneal grafts (RCGs). METHODS: Descemet membrane (DM), endothelium, and retrocorneal membranes make up the total En/DM thickness. These layers are not differentiable by high-definition optical coherence tomography; therefore, the source of thickening is unclear from an in vivo perspective...
September 14, 2017: Cornea
https://www.readbyqxmd.com/read/28915807/descemet-membrane-detachment-in-femtosecond-laser-assisted-cataract-surgery-a-case-report
#20
Peiqing Chen, Yanan Zhu, Ke Yao
BACKGROUND: Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design. CASE PRESENTATION: An 85-year-old man with apparent cornea arcus senilis underwent femtosecond laser-assisted cataract surgery in his right eye. A biplanar model was chosen for the main incision...
September 16, 2017: BMC Ophthalmology
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