Dikki Pedenla Bomzan, Anuj Sharma, Pamela Lemos Cruz, Ines Carqueijeiro, Léo Bellenger, Avanish Rai, Akshay Kumar Thippesh, Venkatesha S Chinnegowda, Durgesh Parihar, Eric Ducos, Vincent Courdavault, Dinesh A Nagegowda
Rho of Plant (ROP) GTPases function as molecular switches that control signaling processes essential for growth, development, and defense. However, their role in specialized metabolism is poorly understood. Previously, we demonstrated that inhibition of protein geranylgeranyl transferase (PGGT-I) negatively impacts the biosynthesis of monoterpenoid indole alkaloids (MIA) in Madagascar periwinkle (Catharanthus roseus), indicating the involvement of prenylated proteins in signaling. Here, we show through biochemical, molecular, and in planta approaches that specific geranylgeranylated ROPs modulate C...
March 11, 2024: Plant Physiology