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https://www.readbyqxmd.com/read/29325450/symptom-science-omics-supports-common-biological-underpinnings-across-symptoms
#1
Maura K McCall, Ansley Grimes Stanfill, Elizabeth Skrovanek, Jessica Renee Pforr, Susan W Wesmiller, Yvette P Conley
For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes. The review yielded 27 genes associated with more than one symptom...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29322921/tensor-decomposition-based-unsupervised-feature-extraction-identifies-candidate-genes-that-induce-post-traumatic-stress-disorder-mediated-heart-diseases
#2
Y-H Taguchi
BACKGROUND: Although post-traumatic stress disorder (PTSD) is primarily a mental disorder, it can cause additional symptoms that do not seem to be directly related to the central nervous system, which PTSD is assumed to directly affect. PTSD-mediated heart diseases are some of such secondary disorders. In spite of the significant correlations between PTSD and heart diseases, spatial separation between the heart and brain (where PTSD is primarily active) prevents researchers from elucidating the mechanisms that bridge the two disorders...
December 21, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29322795/analysis-of-dna-methylation-and-microrna-expression-in-nut-nuclear-protein-in-testis-midline-carcinoma-of-the-sinonasal-tract-a-clinicopathological-immunohistochemical-and-molecular-genetic-study
#3
J Laco, H Kovarikova, M Chmelarova, H Vosmikova, K Sieglova, I Bubancova, P Dundr, K Nemejcova, J Michalek, P Celakovsky, R Mottl, I Sirak, M Vosmik, I Marek, T Geryk, J Mejzlik, J Satankova, A Ryska
The aim of this study was a detailed clinicopathological investigation of sinonasal NUT midline carcinoma (NMC), including analysis of DNA methylation and microRNA (miRNA) expression. Three (5%) cases of NMC were detected among 56 sinonasal carcinomas using immunohistochemical screening and confirmed by fluorescence in situ hybridization. The series comprised 2 males and 1 female, aged 46, 60, and 65 years. Two tumors arose in the nasal cavity and one in the maxillary sinus. The neoplasms were staged pT1, pT3, and pT4a (all cN0M0)...
2018: Neoplasma
https://www.readbyqxmd.com/read/29322790/integrated-network-analysis-to-identify-the-key-genes-transcription-factors-and-micrornas-involved-in-hepatocellular-carcinoma
#4
S Q Shi, J-J Ke, Q S Xu, W Q Wu, Y Y Wan
HCC (hepatocellular carcinoma), which can be induced by cirrhosis and viral hepatitis infection, is the most frequent form of liver cancer. This study is performed to investigate the mechanisms of HCC. GSE57957 was obtained from Gene Expression Omnibus database, including 39 HCC samples and 39 adjacent non-tumorous samples. The DEGs (differentially expressed genes) were screened using the limma package in R, and then were conducted with enrichment analysis using "BioCloud" platform. Using STRING database, WebGestalt tool, as well as ITFP and TRANSFAC databases, PPI (protein-protein interaction) pairs, miRNA (microRNA)-target pairs, and TF (transcription factor)-target pairs separately were predicted...
2018: Neoplasma
https://www.readbyqxmd.com/read/29311229/integrated-analysis-of-proteomic-and-transcriptomic-data-highlights-late-fetal-muscle-maturation-process
#5
Valentin Voillet, Magali San Cristobal, Marie-Christine Pere, Yvon Billon, Laurianne Canario, Laurence Liaubet, Louis Lefaucheur
BACKGROUND: In pigs, the perinatal period is the most critical time for survival. Piglet maturation, which occurs at the end of gestation, leads to a state of full development after birth. Maturity is thus an important determinant of early survival. Skeletal muscle plays a key role in adaptation to extra-uterine life, e.g. motor function and thermoregulation. Progeny from two breeds with extreme neonatal mortality rates were analyzed at 90 and 110 days of gestation (dg). The Large White breed is a highly selected breed for lean growth with a high rate of mortality at birth, whereas the Chinese Meishan breed is fatter and more robust and has a low mortality rate...
January 8, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29311117/expanded-genomic-profiling-of-circulating-tumor-cells-in-metastatic-breast-cancer-patients-to-assess-biomarker-status-and-biology-over-time
#6
Mark Jesus M Magbanua, Hope S Rugo, Denise M Wolfe, Louai Hauranieh, Ritu Roy, Praveen Pendyala, Eduardo Sosa, Janet H Scott, Jin Sun Lee, Brandelyn N Pitcher, Terry M Hyslop, William T Barry, Steven J Isakoff, Maura N Dickler, Laura J Van't Veer, John W Park
Purpose: We profiled circulating tumor cells (CTCs) patients to study the biology of blood-borne metastasis and to monitor biomarker status in metastatic breast cancer (MBC).Methods: CTCs were isolated from 105 MBC patients using EPCAM-based immunomagnetic enrichment and fluorescence-activated cells sorting (IE/FACs), 28 of whom had serial CTC analysis (74 samples, 2-5 time points). CTCs were subjected to microfluidic-based multiplex QPCR array of 64 cancer-related genes (n=151) and genome-wide copy number analysis by array comparative genomic hybridization (n=49)...
January 8, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29306943/clinically-observed-estrogen-receptor-alpha-mutations-within-the-ligand-binding-domain-confer-distinguishable-phenotypes
#7
Shanhang Jia, Mark T Miedel, Marilyn Ngo, Ryan Hessenius, Ning Chen, Peilu Wang, Amir Bahreini, Zheqi Li, Zhijie Ding, Tong Ying Shun, Daniel M Zuckerman, D Lansing Taylor, Shannon L Puhalla, Adrian V Lee, Steffi Oesterreich, Andrew M Stern
OBJECTIVE: Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our study was aimed at investigating distinctive phenotypes conferred by different mutations within this class. METHODS: We examined the two most prevalent mutations, D538G and Y537S, employing corroborative genome-edited and lentiviral-transduced ER+ T47D cell models...
January 6, 2018: Oncology
https://www.readbyqxmd.com/read/29304378/life-course-genome-wide-association-study-meta-analysis-of-total-body-bmd-and-assessment-of-age-specific-effects
#8
Carolina Medina-Gomez, John P Kemp, Katerina Trajanoska, Jian'an Luan, Alessandra Chesi, Tarunveer S Ahluwalia, Dennis O Mook-Kanamori, Annelies Ham, Fernando P Hartwig, Daniel S Evans, Raimo Joro, Ivana Nedeljkovic, Hou-Feng Zheng, Kun Zhu, Mustafa Atalay, Ching-Ti Liu, Maria Nethander, Linda Broer, Gudmar Porleifsson, Benjamin H Mullin, Samuel K Handelman, Mike A Nalls, Leon E Jessen, Denise H M Heppe, J Brent Richards, Carol Wang, Bo Chawes, Katharina E Schraut, Najaf Amin, Nick Wareham, David Karasik, Nathalie Van der Velde, M Arfan Ikram, Babette S Zemel, Yanhua Zhou, Christian J Carlsson, Yongmei Liu, Fiona E McGuigan, Cindy G Boer, Klaus Bønnelykke, Stuart H Ralston, John A Robbins, John P Walsh, M Carola Zillikens, Claudia Langenberg, Ruifang Li-Gao, Frances M K Williams, Tamara B Harris, Kristina Akesson, Rebecca D Jackson, Gunnar Sigurdsson, Martin den Heijer, Bram C J van der Eerden, Jeroen van de Peppel, Timothy D Spector, Craig Pennell, Bernardo L Horta, Janine F Felix, Jing Hua Zhao, Scott G Wilson, Renée de Mutsert, Hans Bisgaard, Unnur Styrkársdóttir, Vincent W Jaddoe, Eric Orwoll, Timo A Lakka, Robert Scott, Struan F A Grant, Mattias Lorentzon, Cornelia M van Duijn, James F Wilson, Kari Stefansson, Bruce M Psaty, Douglas P Kiel, Claes Ohlsson, Evangelia Ntzani, Andre J van Wijnen, Vincenzo Forgetta, Mohsen Ghanbari, John G Logan, Graham R Williams, J H Duncan Bassett, Peter I Croucher, Evangelos Evangelou, Andre G Uitterlinden, Cheryl L Ackert-Bicknell, Jonathan H Tobias, David M Evans, Fernando Rivadeneira
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been identified as associated with BMD. To investigate the genetic determinants of TB-BMD variation along the life course and test for age-specific effects, we performed a meta-analysis of 30 genome-wide association studies (GWASs) of TB-BMD including 66,628 individuals overall and divided across five age strata, each spanning 15 years...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29301444/the-search-of-car-ahr-esrs-binding-sites-in-promoters-of-intronic-and-intergenic-micrornas
#9
Vladimir Y Ovchinnikov, Denis V Antonets, Lyudmila F Gulyaeva
MicroRNAs (miRNAs) play important roles in the regulation of gene expression at the post-transcriptional level. Many exogenous compounds or xenobiotics may affect microRNA expression. It is a well-established fact that xenobiotics with planar structure like TCDD, benzo(a)pyrene (BP) can bind aryl hydrocarbon receptor (AhR) followed by its nuclear translocation and transcriptional activation of target genes. Another chemically diverse group of xenobiotics including phenobarbital, DDT, can activate the nuclear receptor CAR and in some cases estrogen receptors ESR1 and ESR2...
December 10, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/29300923/morphological-analysis-of-the-axonal-projections-of-egfp-labeled-esr1-expressing-neurons-in-transgenic-female-medaka
#10
Buntaro Zempo, Tomomi Karigo, Shinji Kanda, Yasuhisa Akazome, Yoshitaka Oka
Some hypothalamic neurons expressing estrogen receptor α (Esr1) are thought to transmit a gonadal estrogen feedback signal to gonadotropin releasing hormone 1 (GnRH1) neurons, which is the final common pathway for feedback regulation of reproductive functions. Moreover, estrogen-sensitive neurons are suggested to control sexual behaviors in coordination with reproduction. In mammals, hypothalamic estrogen-sensitive neurons release the peptide Kisspeptin and regulate GnRH1 neurons. However, a growing body of evidence in non-mammalian species casts doubt on the regulation of GnRH1 neurons by Kisspeptin neurons...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29298995/nuclear-receptor-gene-polymorphisms-and-warfarin-dose-requirements-in-the-quebec-warfarin-cohort
#11
Payman Shahabi, Félix Lamothe, Stéphanie Dumas, Étienne Rouleau-Mailloux, Yassamin Feroz Zada, Sylvie Provost, Geraldine Asselin, Ian Mongrain, Diane Valois, Marie-Josée Gaulin Marion, Louis-Philippe Lemieux Perreault, Sylvie Perreault, Marie-Pierre Dubé
Warfarin is primarily metabolized by cytochrome 2C9, encoded by gene CYP2C9. Here, we investigated whether variants in nuclear receptor genes which regulate the expression of CYP2C9 are associated with warfarin response. We used data from 906 warfarin users from the Quebec Warfarin Cohort (QWC) and tested the association of warfarin dose requirement at 3 months following the initiation of therapy in nine nuclear receptor genes: NR1I3, NR1I2, NR3C1, ESR1, GATA4, RXRA, VDR, CEBPA, and HNF4A. Three correlated SNPs in the VDR gene (rs4760658, rs11168292, and rs11168293) were associated with dose requirements of warfarin (P = 2...
January 3, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29291017/mir-1271-inhibits-er%C3%AE-expression-and-confers-letrozole-resistance-in-breast-cancer
#12
Tao Yu, Hai-Ru Yu, Jia-Yi Sun, Zhao Zhao, Shuang Li, Xin-Feng Zhang, Zhi-Xuan Liao, Ming-Ke Cui, Juan Li, Chan Li, Qiang Zhang
Attenuation of estrogen receptor α (ERα) expression via unknown mechanism(s) is a hallmark of endocrine-resistant breast cancer (BCa) progression. Here, we report that miR-1271 was significantly down-regulated in letrozole-resistant BCa tissues and in letrozole-resistant BCa cells. miR-1271 directly targeted the chromatin of DNA damage-inducible transcript 3 (DDIT3) gene. miR-1271 expression level was inversely correlated to DDIT3 mRNA level in BCa biopsies. Form a mechanistic standpoint, reintroduction of exogenous miR-1271 could effectively restore ERα level via inhibiting DDIT3 expression, thereby potentiating letrozole sensitivity in BCa cells...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285225/the-protective-value-of-mir-204-5p-for-prognosis-and-its-potential-gene-network-in-various-malignancies-a-comprehensive-exploration-based-on-rna-seq-high-throughput-data-and-bioinformatics
#13
Zhi-Hua Ye, Dong-Yue Wen, Xiao-Yong Cai, Liang Liang, Pei-Rong Wu, Hui Qin, Hong Yang, Yun He, Gang Chen
Purpose: The prognostic role of miR-204-5p (previous ID: miR-204) is varied and inconclusive in diverse types of malignant neoplasm. Therefore, the purposes of the study comprehensively explore the overall prognostic role of miR-204-5p based on high-throughput microRNA sequencing data, and to investigate the potential role of miR-204-5p via bioinformatics approaches. Materials and Methods: The data of microRNA sequencing and survival were downloaded from The Cancer Genome Atlas (TCGA), and the prognostic value of miR-204-5p was analyzed by using Kaplan-Meier and univariate cox regressions...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284708/esr1-methylation-a-liquid-biopsy-based-epigenetic-assay-for-the-follow-up-of-patients-with-metastatic-breast-cancer-receiving-endocrine-treatment
#14
Sofia Mastoraki, Areti Strati, Eleni Tzanikou, Maria Chimonidou, Helen Politaki, Alexandra Voutsina, Amanda Psyrri, Vasilis Georgoulias, Evi S Lianidou
PURPOSE: Liquid biopsy provides real-time monitoring of tumor evolution and response to therapy through analysis of CTCs and plasma-ctDNA. ESR1 epigenetic silencing potentially affects response to endocrine treatment. We evaluated ESR1 methylation in CTCs and paired plasma-ctDNA. We evaluated ESR1 methylation in CTCs and paired plasma-ctDNA as a potential biomarker for response to everolimus/exemestane treatment. EXPERIMENTAL DESIGN: A highly sensitive and specific real-time MSP assay for ESR1 methylation was developed and validated in: a) 65 primary breast tumors (FFPEs), b) EpCAM+ CTC-fractions (122 patients and 30 healthy donors; HD), c) plasma-ctDNA (108 patients and 30HD), d) in CTCs (CellSearch®) and in paired plasma-ctDNA for 58 BrCa patients...
December 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29282666/influence-of-multiwall-carbon-nanotubes-on-the-toxicity-of-17%C3%AE-estradiol-in-the-early-life-stages-of-zebrafish
#15
Zhenhua Yan, Yuxuan Liu, Hongwei Sun, Guanghua Lu
Due to increasing use and release, both multiwall carbon nanotubes (MWCNTs) and 17β-estradiol (E2) may co-exist and interact with each other in aquatic environments. However, little is known about their combined effects on non-target organisms, especially in the presence of other environmental factors. In this study, the interplay between MWCNTs and E2 in the early life stages of zebrafish was investigated, focusing on the alterations in estrogenic responses with and without other environmental factors. There were no significant differences in the hatchability, mortality, or physical development of zebrafish in any treatments...
December 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29278880/hypermethylation-pattern-of-esr-and-pgr-genes-and-lacking-estrogen-and-progesterone-receptors-in-human-breast-cancer-tumors-er-pr-subtypes
#16
Saeed Pirouzpanah, Forough-Azam Taleban, Parvin Mehdipour, Siamak Sabour, Morteza Atri
BACKGROUND: The option of endocrine therapy in breast cancer remains conventionally promising. OBJECTIVE: We aimed to investigate how accurately the pattern of hypermethylation at estrogen receptor (ESR) and progesterone receptor (PgR) genes may associate with relative expression and protein status of ER, PR and the combinative phenotype of ER/PR. METHODS: In this consecutive case-series, we enrolled 139 primary diagnosed breast cancer. Methylation specific PCR was used to assess the methylation status (individual test)...
December 15, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29278418/aberrant-dna-methylation-is-associated-with-aggressive-clinicopathological-features-and-poor-survival-in-cutaneous-melanoma
#17
B de Unamuno Bustos, R Murria Estal, G Pérez Simó, J Simarro Farinos, C Pujol Marco, M Navarro Mira, V Alegre de Miquel, R Ballester Sánchez, V Sabater Marco, M Llavador Ros, S Palanca Suela, R Botella Estrada
BACKGROUND: Promoter methylation of tumor suppressor genes (TSGs) has recently been implicated in the pathogenesis of several types of cancer. Regarding melanoma, over a hundred genes that contribute to its pathogenesis have been identified to be aberrantly hypermethylated. This is a retrospective observational study that aims to analyze the prevalence of CpG island methylation in a series of primary melanoma, to identify the associations with the main clinicopathological features, and to explore the prognostic significance of methylation in melanoma survival...
December 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29277902/divergent-responsiveness-of-two-isoforms-of-the-estrogen-receptor-to-mixtures-of-contaminants-of-emerging-concern-in-four-vertebrates
#18
Satomi Kohno, Yoshinao Katsu, Nicholas Cipoletti, Lina C Wang, Zachary G Jorgenson, Shinichi Miyagawa, Heiko L Schoenfuss
Contaminants of emerging concern (CECs) are ubiquitous in aquatic environments with well-established endocrine-disrupting effects. A data matrix of 559 water samples was queried to identify two commonly occurring CECs mixtures in Great Lakes tributaries. One mixture consisted of eight agricultural CECs (AG), while another contained 11 urban CECs (UB). The known estrogenic compounds bisphenol A, estrone and nonylphenol were present in both mixtures. According to the EPA Tox21 in ToxCast database, AG and UB mixture at an environmentally relevant concentration were estimated to account for 6...
December 26, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29276409/expression-profile-analysis-of-long-noncoding-rna-in-er-positive-subtype-breast-cancer-using-microarray-technique-and-bioinformatics
#19
Jing Peng, Lei Zhang, Chenwei Yuan, Liheng Zhou, Shuguang Xu, Yanping Lin, Jie Zhang, Wenjin Yin, Jinsong Lu
Background: The estrogen receptor (ER)-positive subtype of breast cancer (BC) is the most common type of BC. A number of long noncoding RNAs (lncRNAs) play critical roles in cancer biology, including BC. Previous lncRNA profiling studies have focused only on triple-negative BC and HER 2-positive BC, and no studies have specifically focused on lncRNAs in ER-positive BC. In this study, we analyzed the expression profile of the lncRNAs and mRNAs found in this particular subtype of BC for the first time...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29259034/ablation-of-the-mammalian-lectin-galectin-8-induces-bone-defects-in-mice
#20
Yaron Vinik, Hadas Shatz-Azoulay, Sahar Hiram-Bab, Leonid Kandel, Yankel Gabet, Gurion Rivkin, Yehiel Zick
Mice overexpressing galectin-8 [gal-8 transgenic (Tg)], a secreted mammalian lectin, exhibit enhanced bone turnover and reduced bone mass, similar to cases of postmenopausal osteoporosis. Here, we show that gal-8 knockout (KO) mice have increased bone mass accrual at a young age but exhibit accelerated bone loss during adulthood. These phenotypes can be attributed to a gal-8-mediated increase in receptor activator of NF-κB ligand (RANKL) expression that promotes osteoclastogenesis, combined with direct inhibition of osteoblasts differentiation, evident by reduced bone morphogenetic protein (BMP) signaling, reduced phosphorylation of receptor regulated mothers against decapentaplegic homolog (R-SMAD) and reduced expression of osteoblasts differentiation markers osterix, osteocalcin, runt-related transcription factor 2 (RUNX2), dentin matrix acidic phosphoprotein-1 (DMP1), and alkaline phosphatase...
December 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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