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https://www.readbyqxmd.com/read/28919732/capillary-po2-does-not-adequately-reflect-arterial-po2-in-hypoxemic-copd-patients
#1
Friederike Sophie Magnet, Daniel Sebastian Majorski, Jens Callegari, Sarah Bettina Schwarz, Claudia Schmoor, Wolfram Windisch, Jan Hendrik Storre
PURPOSE: To compare arterial (PaO2) with capillary (PcO2) partial pressure of oxygen in hypoxemic COPD patients because capillary blood gas analysis (CBG) is increasingly being used as an alternative to arterial blood gas analysis (ABG) in a non-intensive care unit setting, although the agreement between PcO2 and PaO2 has not been evaluated in hypoxemic COPD patients. PATIENTS AND METHODS: Bland-Altman comparison of PaO2 and PcO2 served as the primary outcome parameter if PcO2 values were ≤60 mmHg and the secondary outcome parameter if PcO2 values were ≤55 mmHg...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28919151/the-combined-effects-of-ocean-warming-and-acidification-on-shallow-water-meiofaunal-assemblages
#2
Matthew R Lee, Rodrigo Torres, Patricio H Manríquez
Climate change due to increased anthropogenic CO2 in the atmosphere is causing an increase in seawater temperatures referred to as ocean warming and a decrease in seawater pH, referred to as ocean acidification. The meiofauna play an important role in the ecology of marine ecosystems and the functions they provide. Using microcosms, meiofaunal assemblages were exposed to two temperatures (15 and 19 °C) and two pHs (pCO2 of 400 and 1000 ppm), both individually and in combination, for a period of 90 days. The hypothesis that increased temperature will increase meiofaunal abundance was not supported...
September 8, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28918395/non-invasive-high-frequency-oscillatory-ventilation-in-preterm-infants-a-randomised-controlled-cross-over-trial
#3
Daniel Klotz, Hendryk Schneider, Stefan Schumann, Benjamin Mayer, Hans Fuchs
OBJECTIVE: Non-invasive high-frequency oscillatory ventilation (nHFOV) has recently been described as a novel mode of respiratory support for premature infants. This study was designed to determine whether nHFOV decreases CO2 partial pressure (pCO2) in premature infants more effectively than non-invasive continuous positive airway pressure (nCPAP). DESIGN: Non-blinded prospective randomised controlled cross-over study. SETTING: University Medical Center tertiary neonatal intensive care unit...
September 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28915219/intrabronchial-catheter-resuscitation-for-respiratory-and-cardiorespiratory-arrest
#4
Jeffrey S Wolf, Andrea Hebert, Pablo Sanchez, Marniker Wijesinha, Scott Shapiro, Robert Morales, Aldo T Iacono
INTRODUCTION: We sought to determine whether intrabronchial oxygenation would provide adequate gas exchange during both anesthesia induced apneic and cardiopulmonary arrest and cardiac massage (CPR). METHODS: Ten pigs underwent general anesthesia with mechanical ventilation. Blood gases were measured in each animal at 4 min intervals for up to 28 min. An intrabronchial catheter (4 L/min O2) was inserted through an endotracheal tube after respirator cessation. Group A animals (6) were resuscitated with the catheter but without CPR...
September 14, 2017: Shock
https://www.readbyqxmd.com/read/28903842/effect-of-early-%C3%A2-3-mets-metabolic-equivalent-of-tasks-of-physical-activity-on-patient-s-outcome-after-cardiac-surgery
#5
Muhammad Iqbal Tariq, Asif Ali Khan, Zara Khalid, Hania Farheen, Furqan Ahmed Siddiqi, Imran Amjad
OBJECTIVE: To determine the effect of <3 Mets (Metabolic Equivalent of Tasks) of physical activity on zero postoperative days for improving hemodynamic and respiratory parameters of patients after cardiac surgeries. STUDY DESIGN: Randomized control trial. PLACE AND DURATION OF STUDY: BARMWTHospital, Rawalpindi, from March to August 2015. METHODOLOGY: Arandomized controlled trial was conducted on 174 CABG and valvular heart disease patients undergoing cardiac surgical procedures...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28900271/transgenerational-exposure-of-north-atlantic-bivalves-to-ocean-acidification-renders-offspring-more-vulnerable-to-low-ph-and-additional-stressors
#6
Andrew W Griffith, Christopher J Gobler
While early life-stage marine bivalves are vulnerable to ocean acidification, effects over successive generations are poorly characterized. The objective of this work was to assess the transgenerational effects of ocean acidification on two species of North Atlantic bivalve shellfish, Mercenaria mercenaria and Argopecten irradians. Adults of both species were subjected to high and low pCO2 conditions during gametogenesis. Resultant larvae were exposed to low and ambient pH conditions in addition to multiple, additional stressors including thermal stress, food-limitation, and exposure to a harmful alga...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892578/co2-evasion-from-boreal-lakes-revised-estimate-drivers-of-spatial-variability-and-future-projections
#7
Adam Hastie, Ronny Lauerwald, Gesa Weyhenmeyer, Sebastian Sobek, Charles Verpoorter, Pierre Regnier
Lakes (including reservoirs) are an important component of the global carbon (C) cycle, as acknowledged by the 5(th) assessment report of the IPCC. In the context of lakes, the boreal region is disproportionately important contributing to 27% of the worldwide lake area, despite representing just 14% of global land surface area. In this study, we used a statistical approach to derive a prediction equation for the partial pressure of CO2 (pCO2 ) in lakes as a function of lake area, terrestrial net primary productivity (NPP) and precipitation (r(2) = 0...
September 11, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28890467/prediction-of-arterial-blood-gas-values-from-venous-blood-gas-values-in-asiatic-black-bears-ursus-thibetanus-anesthetized-with-intramuscular-medetomidine-and-zolazepam-tiletamine
#8
Dong-Hyuk Jeong, Jeong-Jin Yang, Lyon Lee, Seong-Chan Yeon
The objective of this study was to measure differences between arterial and venous blood gas parameters and to evaluate whether arterial blood gas values can be estimated from venous blood in Asiatic black bears (ABBs). Twelve healthy captive ABBs (8 males and 4 females; 8-16 years; 76.8-220 kg) were included in this study. The bears were immobilized with medetomidine and zolazepam-tiletamine using a dart gun. Arterial and venous samples were collected simultaneously at 5 and 35 min after recumbency (5- and 35-min points)...
September 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28887332/the-cerebro-cardiovascular-response-to-periodic-squat-stand-maneuvers-in-healthy-subjects-a-time-domain-analysis
#9
Sam C Barnes, Naomi Ball, Victoria Joanna Haunton, Thompson G Robinson, Ronney B Panerai
BACKGROUND: Squat-stand maneuvers (SSMs) have been used to improve the coherence of transfer function analysis (TFA) estimates during the assessment of dynamic cerebral autoregulation (dCA). There is a need to understand the influence of peripheral changes resulting from SSMs on cerebral blood flow, which might confound estimates of dCA. METHODS: 29 healthy subjects underwent recordings at rest (5 min standing) and 15 SSMs (0.05Hz). Heart rate (3-lead ECG), end-tidal CO2 (capnography), blood pressure (Finometer), cerebral blood velocity (CBV, transcranial Doppler, MCA) and the angle of the thigh (tilt sensor) were measured continuously...
September 8, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28885956/combat-casualties-and-severe-shock-risk-factors-for-death-at-role-3-military-facilities
#10
Michelle F Buehner, Brian J Eastridge, James K Aden, Joseph J DuBose, Lorne H Blackbourne, Ramon F Cestero
BACKGROUND: Although significant research has been conducted on combat casualties receiving blood products, there is limited data for the subpopulation presenting in shock. The purpose of this study was to evaluate combat casualties arriving to a role 3 facility with an initial systolic blood pressure (SBP) ≤ 90 in order to identify clinical characteristics and associations between presentation, transfusion therapy, and mortality outcomes. METHODS: The Department of Defense Trauma Registry was queried from 2001 to 2010 for trauma-related casualties who arrived at a role 3 combat surgical facility with a SBP ≤ 90...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28879605/in-vitro-evaluation-of-limitations-and-possibilities-for-the-future-use-of-intracorporeal-gas-exchangers-placed-in-the-upper-lobe-position
#11
Erin Schumer, Klaus Höffler, Christian Kuehn, Mark Slaughter, Axel Haverich, Bettina Wiegmann
The lack of donor organs has led to the development of alternative "destination therapies", such as a bio-artificial lung (BA) for end-stage lung disease. Ultimately aiming at a fully implantable BA, general capabilities and limitations of different oxygenators were tested based on the model of BA positioning at the right upper lobe. Three different-sized oxygenators (neonatal, paediatric, and adult) were tested in a mock circulation loop regarding oxygenation and decarboxylation capacities for three respiratory pathologies...
September 6, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28875449/an-extracorporeal-carbon-dioxide-removal-ecco2r-device-operating-at-hemodialysis-blood-flow-rates
#12
R Garrett Jeffries, Laura Lund, Brian Frankowski, William J Federspiel
BACKGROUND: Extracorporeal carbon dioxide removal (ECCO2R) systems have gained clinical appeal as supplemental therapy in the treatment of acute and chronic respiratory injuries with low tidal volume or non-invasive ventilation. We have developed an ultra-low-flow ECCO2R device (ULFED) capable of operating at blood flows comparable to renal hemodialysis (250 mL/min). Comparable operating conditions allow use of minimally invasive dialysis cannulation strategies with potential for direct integration to existing dialysis circuitry...
September 6, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28875158/thirty-days-of-spaceflight-does-not-alter-murine-calvariae-structure-despite-increased-sost-expression
#13
Timothy R Macaulay, Jamila H Siamwala, Alan R Hargens, Brandon R Macias
Previously our laboratory documented increases in calvaria bone volume and thickness in mice exposed to 15 days of spaceflight aboard the NASA Shuttle mission STS-131. However, the tissues were not processed for gene expression studies to determine what bone formation pathways might contribute to these structural adaptations. Therefore, this study was designed to investigate both the structural and molecular changes in mice calvariae after a longer duration of spaceflight. The primary purpose was to determine the calvaria bone volume and thickness of mice exposed to 30 days of spaceflight using micro-computed tomography for comparison with our previous findings...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28870859/ocean-acidification-and-pathogen-exposure-modulate-the-immune-response-of-the-edible-mussel-mytilus-chilensis
#14
Nicole Castillo, Luisa M Saavedra, Cristian A Vargas, Cristian Gallardo-Escárate, Camille Détrée
Ocean acidification (OA) is one of the main consequences of increasing atmospheric carbon dioxide (CO2), impacting key biological processes of marine organisms such as development, growth and immune response. However, there are scarce studies on the influence of OA on marine invertebrates' ability to cope with pathogens. This study evaluated the single and combined effects of OA and bacterial infection on the transcription expression of genes related to antioxidant system, antimicrobial peptides and pattern recognition receptors in the edible mussel Mytilus chilensis...
September 1, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28860652/diel-co2-cycles-reduce-severity-of-behavioural-abnormalities-in-coral-reef-fish-under-ocean-acidification
#15
Michael D Jarrold, Craig Humphrey, Mark I McCormick, Philip L Munday
Elevated CO2 levels associated with ocean acidification (OA) have been shown to alter behavioural responses in coral reef fishes. However, all studies to date have used stable pCO2 treatments, not considering the substantial diel pCO2 variation that occurs in shallow reef habitats. Here, we reared juvenile damselfish, Acanthochromis polyacanthus, and clownfish, Amphiprion percula, at stable and diel cycling pCO2 treatments in two experiments. As expected, absolute lateralization of A. polyacanthus and response to predator cue of Am...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852515/the-effects-of-elevated-temperature-and-ocean-acidification-on-the-metabolic-pathways-of-notothenioid-fish
#16
Laura A Enzor, Evan M Hunter, Sean P Place
The adaptations used by notothenioid fish to combat extreme cold may have left these fish poorly poised to deal with a changing environment. As such, the expected environmental perturbations brought on by global climate change have the potential to significantly affect the energetic demands and subsequent cellular processes necessary for survival. Despite recent lines of evidence demonstrating that notothenioid fish retain the ability to acclimate to elevated temperatures, the underlying mechanisms responsible for temperature acclimation in these fish remain largely unknown...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28843675/aerosol-furosemide-for-dyspnea-high-dose-controlled-delivery-does-not-improve-effectiveness
#17
Robert B Banzett, Richard M Schwartzstein, Robert W Lansing, Carl R O'Donnell
Published studies have shown great variability in response when aerosolized furosemide has been tested as a palliative treatment for dyspnea. We hypothesized that a higher furosemide dose with controlled aerosol administration would produce consistent dyspnea relief. We optimized deposition by controlling inspiratory flow (300-500mL/s) and tidal volume (15% predicted vital capacity) while delivering 3.4μm aerosol from either saline or 80mg of furosemide. We induced dyspnea in healthy subjects by varying inspired PCO2 while restricting minute ventilation...
August 24, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28836153/agreement-between-venous-and-arterial-blood-gas-analysis-of-acid-base-status-in-critical-care-and-ward-patients-a-retrospective-cohort-study
#18
Claudio M Martin, Fran Priestap
PURPOSE: To determine whether the use of venous blood gases can be a suitable alternative to arterial sampling to evaluate acid-base status. METHODS: The database of the clinical laboratory in a large academic hospital was searched for records of venous blood gas analysis and an arterial sample taken within ten minutes from the same patient. Bland-Altman analyses of pH, pCO2, and lactate were performed for samples obtained from patients separately from within and outside the intensive care unit (ICU)...
August 23, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28835644/co2-and-temperature-decoupling-at-the-million-year-scale-during-the-cretaceous-greenhouse
#19
Abel Barral, Bernard Gomez, François Fourel, Véronique Daviero-Gomez, Christophe Lécuyer
CO2 is considered the main greenhouse gas involved in the current global warming and the primary driver of temperature throughout Earth's history. However, the soundness of this relationship across time scales and during different climate states of the Earth remains uncertain. Here we explore how CO2 and temperature are related in the framework of a Greenhouse climate state of the Earth. We reconstruct the long-term evolution of atmospheric CO2 concentration (pCO2) throughout the Cretaceous from the carbon isotope compositions of the fossil conifer Frenelopsis...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28834879/effect-of-acid-base-balance-on-postoperative-course-in-children-with-hypoplastic-left-heart-syndrome-after-the-modified-norwood-procedure
#20
Marcin Gładki, Tomasz Składzień, Rafał Żurek, Elżbieta Broniatowska, Elżbieta Wójcik, Janusz H Skalski
Hypoplastic left heart syndrome (HLHS) is a congenital heart defect that requires 3-stage cardiac surgical treatment and multidirectional specialist care. The condition of newborns in the first postoperative days following the modified Norwood procedure is characterized by considerable hemodynamic instability that may result in a sudden cardiac arrest. It is believed that the most important cause of hemodynamic instability is the fluctuations in redistribution between pulmonary and systemic blood flow.The paper analyzes the postoperative course in 40 neonates with HLHS following the modified Norwood procedure performed under deep hypothermic cardiopulmonary bypass hospitalized in Cardiac Surgical Intensive Care Unit (CSICU) in the years 2014-2015...
August 2017: Medicine (Baltimore)
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