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Idiopathic urticaria

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https://www.readbyqxmd.com/read/28328088/evaluation-of-the-correlation-between-severity-of-acquired-idiopathic-generalized-anhidrosis-and-quality-of-life-scores
#1
Takichi Munetsugu, Tomoko Fujimoto, Takahiro Satoh, Yoshihiko Nakazato, Yuichiro Ohshima, Masato Asahina, Hiroo Yokozeki
Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. However, the effects of AIGA severity on the quality of life (QOL) of the patients have not been sufficiently defined. The objective of this study was to evaluate the correlation between AIGA severity and QOL...
March 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28302451/chronic-idiopathic-urticaria-systemic-complaints-and-their-relationship-with-disease-and-immune-measures
#2
Judy C Doong, Kris Chichester, Eric T Oliver, Lawrence B Schwartz, Sarbjit S Saini
BACKGROUND: Patients with chronic idiopathic urticaria (CIU)/chronic spontaneous urticaria sometimes report systemic complaints (SCs). OBJECTIVE: We sought to determine the frequency and characteristics of SCs among patients with CIU, as well as the association of SCs with disease measures, basophil histamine release, and serum tryptase. METHODS: Adult patients with CIU were recruited from a university allergy clinic. Patients completed a disease symptom survey and underwent blood sampling for subsequent basophil histamine release and serum tryptase measurement...
March 13, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28299827/factors-linked-to-disease-severity-and-time-to-remission-in-patients-with-chronic-spontaneous-urticaria
#3
REVIEW
Mario Sánchez-Borges, Fernan Caballero-Fonseca, Arnaldo Capriles-Hulett, Luis González-Aveledo, Marcus Maurer
BACKGROUND: Biomarkers useful for the evaluation and management of patients with chronic spontaneous urticaria (CSU) are not currently available. OBJECTIVE: A review of various clinical and laboratory markers that have been studied to assess their value for determining the severity or predicting the evolution of disease in adult patients with CSU. METHODS: A search of the medical literature on Pubmed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria, severity, prognosis, and treatment...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28295553/serum-carcinoembryonic-antigen-specifically-increases-among-various-serum-markers-of-adenocarcinoma-in-hypohidrosis-or-conditions-related-to-hypohidrosis
#4
Masaru Honma, Hiroyoshi Nozaki, Hiroko Nagahata, Mizue Fujii, Takashi Shibuya, Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto
Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. This study was performed to verify the specificity and independence of serum CEA level from the other serum tumor markers especially related to adenocarcinoma...
March 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28295198/analysis-of-disease-activity-categories-in-chronic-spontaneous-idiopathic-urticaria
#5
D Stull, D McBride, H Tian, A Gimenez Arnau, M Maurer, A Marsland, M-M Balp, S Khalil, C Grattan
BACKGROUND: Measurement of disease activity guides treatment of chronic spontaneous urticaria (CSU). A weekly Urticaria Activity Score-here, the average of twice-daily patient assessment of itch and hives scores summed over 1 week (UAS7TD )-measures severity from 0 to 42. Insufficient evidence exists whether disease activity states, defined by categorical UAS7TD scores, correlate with other patient-reported outcomes and treatment response. OBJECTIVE: To evaluate and compare categorical UAS7TD scores with selected measures of disease-related quality of life and impact...
March 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28226418/omalizumab-for-the-treatment-of-chronic-idiopathic-urticaria-systematic-review-of-the-literature
#6
Alessandro Tonacci, Lucia Billeci, Giovanni Pioggia, Michele Navarra, Sebastiano Gangemi
Omalizumab is recombinant humanized monoclonal antibody to immunoglobulin E. Guidelines for the treatment of chronic idiopathic urticaria (also known as chronic spontaneous urticaria) recommend the use of omalizumab as third-line therapy in addition to high doses of histamine receptor type 1 (H1 ) antihistamines when they are unsuccessful as first- and second-line therapy. We performed a systematic review of the literature to identify studies that evaluated the efficacy of omalizumab for the treatment of chronic idiopathic urticaria, both in controlled and real-world settings, to assess its potential role as a preferred therapy...
February 22, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28219063/elevated-nitrosative-stress-in-children-with-chronic-spontaneous-urticaria
#7
Fatih Dilek, Deniz Ozceker, Emin Ozkaya, Eray Metin Guler, Mebrure Yazici, Zeynep Tamay, Abdurrahim Kocyigit, Nermin Guler
BACKGROUND: Chronic spontaneous urticaria (CSU) is an idiopathic condition that seriously affects quality of life. It is well known that oxidative stress and nitrosative stress (NS) are generally involved in many chronic inflammatory diseases. This study aimed to evaluate the possible role of NS in the pathogenesis of CSU. METHODS: Thirty-two children with CSU and 22 healthy control subjects were enrolled in the study. Demographic and clinical features were defined, and disease activity was quantified using the urticaria activity score (UAS)...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28193678/aspirin-desensitization-in-patients-with-coronary-artery-disease-results-of-the-multicenter-adapted-registry-aspirin-desensitization-in-patients-with-coronary-artery-disease
#8
Roberta Rossini, Annamaria Iorio, Roberto Pozzi, Matteo Bianco, Giuseppe Musumeci, Sergio Leonardi, Corrado Lettieri, Irene Bossi, Paola Colombo, Stefano Rigattieri, Cinzia Dossena, Angelo Anzuini, Davide Capodanno, Michele Senni, Dominick J Angiolillo
BACKGROUND: There are limited data on aspirin (ASA) desensitization for patients with coronary artery disease. The aim of the present study was to assess the safety and efficacy of a standard rapid desensitization protocol in patients with ASA sensitivity undergoing coronary angiography. METHODS AND RESULTS: This is a prospective, multicenter, observational study including 7 Italian centers including patients with a history of ASA sensitivity undergoing coronary angiography with intent to undergo percutaneous coronary intervention...
February 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28094164/disorders-characterized-by-predominant-or-exclusive-dermal-inflammation
#9
Mark R Wick
Some cutaneous inflammatory disorders are typified by a predominant or exclusive localization in the dermis. They can be further subdivided by the principal cell types into lymphocytic, neutrophilic, and eosinophilic infiltrates, and mixtures of them are also seen in a proportion of cases. This review considers such conditions. Included among the lymphoid lesions are viral exanthems, pigmented purpuras, gyrate erythemas, polymorphous light eruption, lupus tumidus, and cutaneous lymphoid hyperplasia. Neutrophilic infiltrates are represented by infections, Sweet syndrome, pyoderma gangrenosum, and hidradenitis suppurativa, as well as a group of so-called "autoinflammatory" dermatitides comprising polymorphonuclear leukocytes...
December 14, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28007089/epidemiology-of-anaphylaxis-at-a-tertiary-care-center-a-report-of-730-cases
#10
Alexei Gonzalez-Estrada, Stacy K Silvers, Asaf Klein, Katrina Zell, Xiao-Feng Wang, David M Lang
BACKGROUND: Recent data reveal that the rate of anaphylaxis is increasing and suggest that idiopathic anaphylaxis may account for most of these cases. OBJECTIVE: To determine the pattern of anaphylaxis at a tertiary care referral center. METHODS: A retrospective electronic medical record review spanning 12 years (2002-2013) identified patients with anaphylaxis. RESULTS: Of the 4,777 records reviewed, 730 patients met our anaphylaxis definition...
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27971869/assure-csu-resource-use-and-economic-burden-in-patients-with-refractory-chronic-spontaneous-idiopathic-urticaria-in-italy
#11
A Roccia, L Rigoni, M R Cawson, D McBride, G W Canonica, M Balp
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971645/comparative-analysis-of-indirect-costs-associated-with-chronic-spontaneous-idiopathic-urticaria-results-from-the-assure-csu-study-in-7-countries
#12
D McBride, M Abuzakouk, M Balp, F Berard, G W Canonica, A Gimenez-Arnau, C Grattan, K Hollis, S Khalil, A Knulst, J Lacour, C Lynde, A Marsland, M Maurer, A Nakonechna, F J Ortiz de Frutoz, J Oude Elberink, C Proctor, G Sussman, K Weller
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971634/assessing-health-utility-values-for-chronic-spontaneous-idiopathic-urticaria-in-real-world-using-the-eq-5d-results-from-assure-csu-study
#13
K Hollis, M Abuzakouk, M Balp, F Berard, G W Canonica, A Gimenez-Arnau, C Grattan, S Khalil, A C Knulst, J Lacour, C Lynde, M Maurer, D McBride, A Nakonechna, F J Ortiz de Frutoz, J Oude Elberink, C Proctor, G Sussman, C Sweeney, H Tian, K Weller, A Marsland
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971603/comparison-of-direct-healthcare-costs-associated-with-chronic-spontaneous-idiopathic-urticaria-in-7-countries-results-from-the-assure-csu-study
#14
M Balp, M Abuzakouk, F Berard, G W Canonica, A Gimenez-Arnau, K Hollis, S Khalil, A Knulst, J Lacour, C Lynde, A Marsland, M Maurer, D McBride, A Nakonechna, F J Ortiz de Frutoz, J Oude Elberink, C Proctor, G Sussman, K Weller, C Grattan
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27957325/immunogenicity-of-a-peptide-based-anti-ige-conjugate-vaccine-in-non-human-primates
#15
Risini D Weeratna, Ghania Chikh, Lu Zhang, James D Fraser, Jennifer M Thorn, James R Merson, Michael J McCluskie, Brian R Champion, Heather L Davis
The anti-human immunoglobulin E (IgE) monoclonal antibody, omalizumab (Xolair®, Genentech, South San Fransisco, CA), is effective in the treatment of poorly controlled moderate to severe allergic asthma and chronic idiopathic urticaria. It acts by specifically binding to the constant domain (Cϵ3) of free human IgE in the blood and interstitial fluid. Although efficacious, use of omalizumab is limited due to restrictions on patient weight and pre-existing IgE levels, and frequent dosing (q2-4 weeks). A vaccine inducing anti-IgE antibodies has the potential for similar clinical benefits with less frequent dosing and relatively lower cost of goods...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27939380/effect-of-omalizumab-on-blood-basophil-counts-in-patients-with-chronic-idiopathic-spontaneous-urticaria
#16
Sarbjit S Saini, Theodore A Omachi, Benjamin Trzaskoma, Henry N Hulter, Karin Rosén, Patricia M Sterba, Jean-Paul Courneya, Alan Lackey, Hubert Chen
No abstract text is available yet for this article.
December 6, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27931301/corticosteroid-related-toxicity-in-patients-with-chronic-idiopathic-urticariachronic-spontaneous-urticaria
#17
Dennis Ledford, Michael S Broder, Evgeniya Antonova, Theodore A Omachi, Eunice Chang, Allan Luskin
BACKGROUND: Treatments for patients with chronic idiopathic urticaria (CIU)chronic spontaneous urticaria (CSU) who were unresponsive to antihistamines include oral corticosteroids (OCS). Risks of OCS-related side effects in these patients have not been described quantitatively. OBJECTIVE: To investigate the relationship between OCS use and the risk of developing side effects possibly attributable to OCS and associated health care costs in privately insured patients with CIU/CSU...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27911016/positive-impact-of-omalizumab-on-angioedema-and-quality-of-life-in-patients-with-refractory-chronic-idiopathic-spontaneous-urticaria-analyses-according-to-the-presence-or-absence-of-angioedema
#18
M Maurer, H Sofen, B Ortiz, F Kianifard, S Gabriel, J A Bernstein
BACKGROUND: Approximately 50% of patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) report hives and angioedema; some experience hives/angioedema only. OBJECTIVE: Assess omalizumab's effect on angioedema and quality of life (QoL) in subgroups with refractory CIU/CSU: those with and without angioedema. METHODS: Patients received omalizumab (75, 150 or 300 mg) or placebo every 4 weeks for 12/24 weeks. Angioedema and QoL were assessed [Urticaria Patient Daily Diary and Dermatology Quality of Life Index (DLQI)]...
December 2, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27886907/differential-diagnosis-of-chronic-urticaria-and-angioedema-based-on-molecular-biology-pharmacology-and-proteomics
#19
REVIEW
David H Dreyfus
Differential diagnosis of urticaria and angioedema has been based on the phenotype as either acute or chronic depending on the duration of more than 6 to 8 weeks, respectively. Additional subdivisions include poorly defined terms such as idiopathic, spontaneous, or autoimmune. In this article, the author suggests that an increased understanding of the acquired and innate immune system and data from novel proteomic technology have blurred the lines between these categories of diagnosis. Specific molecular pathways and response to specific medications should be incorporated in classification and diagnosis schemes...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27861988/mechanisms-of-action-that-contribute-to-efficacy-of-omalizumab-in-chronic-spontaneous-urticaria
#20
REVIEW
A P Kaplan, A M Giménez-Arnau, S S Saini
The monoclonal anti-immunoglobulin E (IgE) antibody, omalizumab, was the first drug approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who remain symptomatic despite H1 -antihistamine treatment. Omalizumab binds to free IgE, which lowers free IgE levels and causes FcεRI receptors on basophils and mast cells to be downregulated. It has been shown to improve symptoms of CIU/CSU, but its mechanism of action is not currently understood. Potential mechanisms in CIU/CSU include reducing mast cell releasability, reversing basopenia and improving basophil IgE receptor function, reducing activity of IgG autoantibodies against FcεRI and IgE, reducing activity of IgE autoantibodies against an antigen or autoantigen that has yet to be definitively identified, reducing the activity of intrinsically 'abnormal' IgE, and decreasing in vitro coagulation abnormalities associated with disease activity...
April 2017: Allergy
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