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https://www.readbyqxmd.com/read/29150721/adaptive-snp-set-association-testing-in-generalized-linear-mixed-models-with-application-to-family-studies
#1
Jun Young Park, Chong Wu, Saonli Basu, Matt McGue, Wei Pan
In genome-wide association studies (GWAS), it has been increasingly recognized that, as a complementary approach to standard single SNP analyses, it may be beneficial to analyze a group of functionally related SNPs together. Among the existent population-based SNP-set association tests, two adaptive tests, the aSPU test and the aSPUpath test, offer a powerful and general approach at the gene- and pathway-levels by data-adaptively combining the results across multiple SNPs (and genes) such that high statistical power can be maintained across a wide range of scenarios...
November 17, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/29150450/aerobic-power-and-flight-capacity-in-birds-a-phylogenetic-test-of-the-heart-size-hypothesis
#2
Roberto F Nespolo, César González-Lagos, Jaiber J Solano-Iguaran, Magnus Elfwing, Alvaro Garitano-Zavala, Santiago Mañosa, Juan Carlos Alonso, Jordi Altimiras
Flight capacity is one of the most important innovations in animal evolution; it only evolved in insects, birds, mammals and the extinct pterodactyls. Given that powered flight represents a demanding aerobic activity, an efficient cardiovascular system is essential for the continuous delivery of oxygen to the pectoral muscles during flight. It is well known that the limiting step in the circulation is stroke volume (the volume of blood pumped from the ventricle to the body during each beat), which is determined by the size of the ventricle...
November 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29149201/the-influence-of-filtering-and-downsampling-on-the-estimation-of-transfer-entropy
#3
Immo Weber, Esther Florin, Michael von Papen, Lars Timmermann
Transfer entropy (TE) provides a generalized and model-free framework to study Wiener-Granger causality between brain regions. Because of its nonparametric character, TE can infer directed information flow also from nonlinear systems. Despite its increasing number of applications in neuroscience, not much is known regarding the influence of common electrophysiological preprocessing on its estimation. We test the influence of filtering and downsampling on a recently proposed nearest neighborhood based TE estimator...
2017: PloS One
https://www.readbyqxmd.com/read/29148964/twenty-five-years-of-the-binary-power-law-for-characterizing-heterogeneity-of-disease-incidence
#4
Laurence V Madden, Gareth Hughes, Wanderson Bucker Moraes, Xiangming Xu, William W Turechek
Spatial pattern, an important epidemiological property of plant diseases, can be quantified at different scales using a range of methods. The spatial heterogeneity (or overdispersion) of disease incidence among sampling units is an especially important measure of small-scale pattern. As an alternative to Taylor's power law for the heterogeneity of counts with no upper bound, the binary power law (BPL) was proposed in 1992 as a model to represent the heterogeneity of disease incidence (number of plant units diseased out of n observed in each sampling unit, or the proportion diseased in each sampling unit)...
November 17, 2017: Phytopathology
https://www.readbyqxmd.com/read/29148432/a-singular-value-decomposition-linear-programming-svdlp-optimization-technique-for-circular-cone-based-robotic-radiotherapy
#5
Bin Liang, Yongbao Li, Wei Ran, Bin Guo, Xuang Xu, Bo Liu, Jiafeng Li, Qiuwen Wu, Fugen Zhou
With robot-controlled linac positioning, the robotic radiotherapy system such as CyberKnife significantly increases the freedom in radiation beam placement, but also imposes more challenges on treatment plan optimization. The resampling mechanism in vendor supplied treatment planning system (MultiPlan) could not fully explore the increased beam direction search space. Besides, a sparse treatment plan (using fewer beams) is desired to improve the treatment efficiency. This study proposes a singular value decomposition linear programming (SVDLP) optimization technique for circular collimator based robotic radiotherapy...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29146023/longitudinal-associations-of-pericardial-and-intrathoracic-fat-with-progression-of-coronary-artery-calcium-from-the-framingham-heart-study
#6
Jane J Lee, Alison Pedley, Udo Hoffmann, Joseph M Massaro, Christopher J O'Donnell, Emelia J Benjamin, Michelle T Long
Cross-sectional studies have shown that pericardial fat is associated with atherosclerotic burden above and beyond generalized and central adiposity. Whether pericardial fat is longitudinally associated with coronary artery calcium (CAC) has not been firmly established. We examined the associations between cardiac ectopic fat including pericardial and intrathoracic fat with CAC progression and incidence in a community-based study setting. Study participants were from the Framingham Heart Study Offspring and Third Generation Cohorts who underwent multidetector computed tomography at 2 consecutive examinations (2002 to 2005 and 2008 to 2011) for the assessment of CAC...
October 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29145852/a-preliminary-evaluation-of-influence-of-body-mass-index-on-in-vitro-fertilization-outcome-in-non-obese-endometriosis-patients
#7
Eliana Garalejic, Biljana Arsic, Jovana Radakovic, Dragana Bojovic Jovic, Dragana Lekic, Biljana Macanovic, Ivan Soldatovic, Milan Perovic
BACKGROUND/AIMS: Obese and overweight women experience a lower probability for pregnancy after IVF. However, despite the increasing prevalence of obesity, the large majority of infertile women are non-obese. One of the most common indications for IVF is endometriosis. Thought-provoking inverse correlation has been established between BMI and endometriosis. Lower BMI is a risk factor for development of endometriosis and a predictive factor for severe endometriosis. Since severe endometriosis carries lower reproductive chances, even after IVF, we preliminary tested a hypothesis that higher BMI among non-obese endometriosis patients improves IVF outcomes...
November 16, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29145288/efficacy-of-cold-application-on-pain-during-chest-tube-removal-a-randomized-controlled-trial-a-consort-compliant-article
#8
Ling-Yu Hsieh, Yi-Rong Chen, Mei-Chun Lu
BACKGROUND: Use of analgesics is the most common method to alleviate the pain induced by chest tube removal (CTR), but patient response to medication can vary and may not be achieved complete relaxation. This study was to determine the effectiveness of cold application in combination with standard analgesic administration before CTR on CTR-induced pain. METHODS: A prospective, randomized, single-blind, sham-controlled study was conducted. In addition to the same routine care, subjects in the experimental group (n = 30) received cold application of 600-g ice packs 15 minutes before CTR, whereas subjects in the sham group (n = 30) received tap water packs...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144214/circadian-rhythms-of-trematode-parasites-applying-mixed-models-to-test-underlying-patterns
#9
Emily R Hannon, Dana M Calhoun, Sindhu Chadalawada, Pieter T J Johnson
Circadian rhythms of parasites and their hosts can influence processes such as transmission, pathology and life cycle evolution. For trematode parasites that depend on free-living infectious stages (i.e. cercariae) to move among host species, the timing of parasite release is hypothesized to increase the likelihood of contacting a host. Yet, a persistent challenge in studying such biorhythms involves selection of appropriate analytical techniques. Here, we extend a generalized linear mixed modelling (GLMM) framework to cosinor analyses, thereby allowing flexibility in the statistical distribution of the response variable, incorporation of multiple covariates and inclusion of hierarchical grouping effects...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29143703/dose-response-evaluation-of-the-standardized-ileal-digestible-tryptophan-lysine-ratio-to-maximize-growth-performance-of-growing-finishing-gilts-under-commercial-conditions
#10
M A D Gonçalves, M D Tokach, N M Bello, K J Touchette, R D Goodband, J M DeRouchey, J C Woodworth, S S Dritz
Environmental regulations as well as economic incentives have resulted in greater use of synthetic amino acids in swine diets. Tryptophan is typically the second limiting amino acid in corn-soybean meal-based diets. However, using corn-based co-products emphasizes the need to evaluate the pig's response to increasing Trp concentrations. Therefore, the objective of these studies was to evaluate the dose-response to increasing standardized ileal digestible (SID) Trp : Lys on growth performance of growing-finishing gilts housed under large-scale commercial conditions...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29142985/low-urinary-creatinine-excretion-is-associated-with-self-reported-frailty-in-patients-with-advanced-chronic-kidney-disease
#11
Harmke A Polinder-Bos, Hakan Nacak, Friedo W Dekker, Stephan J L Bakker, Carlo A J M Gaillard, Ron T Gansevoort
Introduction: Frailty and muscle wasting, a component of frailty, are common in advanced stage chronic kidney disease (CKD). Whether frailty is associated with low urinary creatinine excretion (UCrE) as a measure of muscle mass in this population is unknown. Furthermore, reference values of UCrE are lacking. We first defined low UCrE and studied correlates of low UCrE, and subsequently studied cross-sectional associations of frailty with low UCrE in patients with advanced CKD. Methods: A total of 2748 healthy individuals of the general population-based PREVEND study were included to define low UCrE (UCrE indexed for height, below the age- and sex-specific 5th percentile of the distribution)...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142542/predictors-and-correlations-of-emotional-intelligence-among-medical-students-at-king-abdulaziz-university-jeddah
#12
Nahla Khamis Ibrahim, Wafaa Ali Algethmi, Safia Mohammad Binshihon, Rawan Aesh Almahyawi, Razan Faisal Alahmadi, Maha Yousef Baabdullah
Objectives: To determine the predictors of Emotional Intelligence (EI), and its relationship with academic performance, leadership capacity, self-efficacy and the perceived stress between medical students at King Abdulaziz University, Jeddah, Saudi Arabia. Methods: A cross-sectional study was done among 540 students selected through a multi-stage stratified random sampling method during 2015/2016. A standardized, confidential data collection sheet was used. It included Schutte Self-Report Emotional Intelligence (SSREI) scale, Authentic Leadership questionnaire, General Self-Efficacy Scale and the short version of Perceived Stress Scale (PSS-4)...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29142333/approaches-to-macroevolution-1-general-concepts-and-origin-of-variation
#13
David Jablonski
Approaches to macroevolution require integration of its two fundamental components, i.e. the origin and the sorting of variation, in a hierarchical framework. Macroevolution occurs in multiple currencies that are only loosely correlated, notably taxonomic diversity, morphological disparity, and functional variety. The origin of variation within this conceptual framework is increasingly understood in developmental terms, with the semi-hierarchical structure of gene regulatory networks (GRNs, used here in a broad sense incorporating not just the genetic circuitry per se but the factors controlling the timing and location of gene expression and repression), the non-linear relation between magnitude of genetic change and the phenotypic results, the evolutionary potential of co-opting existing GRNs, and developmental responsiveness to nongenetic signals (i...
2017: Evolutionary Biology
https://www.readbyqxmd.com/read/29142314/magnetoresistance-and-robust-resistivity-plateau-in-moas2
#14
Jialu Wang, Lin Li, Wei You, Tingting Wang, Chao Cao, Jianhui Dai, Yuke Li
We have grown the MoAs2 single crystal which crystallizes in a monoclinic structure with C2/m space group. Transport measurements show that MoAs2 displays a metallic behavior at zero field and undergoes a metal-to-semiconductor crossover at low temperatures when the applied magnetic field is over 5 T. A robust resistivity plateau appears below 18 K and persists for the field up to 9 T. A large positive magnetoresistance (MR), reaching about 2600% at 2 K and 9 T, is observed when the field is perpendicular to the current...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141680/applying-a-community-based-participatory-research-approach-to-improve-access-to-healthcare-for-eritrean-asylum-seekers-in-israel-a-pilot-study
#15
Nora Gottlieb, Tomer Weinstein, Jonah Mink, Habtom M Ghebrezghiabher, Zebib Sultan, Rachel Reichlin
BACKGROUND: Israel hosts approximately 50,000 asylum seekers, most of them from Eritrea. Exclusive policies restrict their access to healthcare. In 2013, local activists partnered with Eritrean asylum seekers to assess health needs as well as willingness to pay for health insurance among the Eritrean communities. This initiative was meant as a step towards jointly advocating access to Israel's public healthcare system and towards strengthening collective efficacy among the asylum-seeking communities, as well as a first attempt to apply a community-based participatory research (CBPR) approach to migrant health research in Israel...
November 15, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29141612/individual-level-and-community-level-determinants-of-cervical-cancer-screening-among-kenyan-women-a-multilevel-analysis-of-a-nationwide-survey
#16
Fentanesh Nibret Tiruneh, Kun-Yang Chuang, Peter Austin Morton Ntenda, Ying-Chih Chuang
BACKGROUND: Studies on the determinants of cervical cancer screening in sub-Saharan Africa have focused mostly on individual-level characteristics of cervical cancer screening. Therefore, in this study, we included both individual- and community-level indicators to examine the determinants of cervical cancer screening among Kenyan women. METHODS: We analyzed data from the 2014 Kenya Demographic and Health Surveys. Our analysis focused on 9016 married women of reproductive age (15-49 years)...
November 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29141342/-influence-of-humidex-on-incidence-of-bacillary-dysentery-in-hefei-a-time-series-study
#17
H Zhang, K F Zhao, R X He, D S Zhao, M Y Xie, S S Wang, L J Bai, Q Cheng, Y W Zhang, H Su
Objective: To investigate the effect of humidex combined with mean temperature and relative humidity on the incidence of bacillary dysentery in Hefei. Methods: Daily counts of bacillary dysentery cases and weather data in Hefei were collected from January 1, 2006 to December 31, 2013. Then, the humidex was calculated from temperature and relative humidity. A Poisson generalized linear regression combined with distributed lag non-linear model was applied to analyze the relationship between humidex and the incidence of bacillary dysentery, after adjusting for long-term and seasonal trends, day of week and other weather confounders...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141100/religiosity-and-psychological-resilience-in-patients-with-schizophrenia-and-bipolar-disorder-an-international-cross-sectional-study
#18
Y Mizuno, A Hofer, B Frajo-Apor, F Wartelsteiner, G Kemmler, S Pardeller, T Suzuki, M Mimura, W W Fleischhacker, H Uchida
OBJECTIVE: The impact of religious/spiritual activities on clinical outcomes in patients with serious mental illnesses remains controversial, which was addressed in this international cross-sectional study. METHOD: Three-hundred sixty-nine subjects were recruited from Austria (n = 189) and Japan (n = 180), consisting of 112 outpatients with paranoid schizophrenia, 120 with bipolar I disorder (DSM-IV), and 137 healthy controls. Religiosity was assessed in terms of attendance and importance of religious/spiritual activities, while resilience was assessed using the 25-item Resilience Scale...
November 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29140945/a-retrospective-cohort-study-of-the-incidence-health-care-resource-utilization-and-costs-of-international-classification-of-diseases-clinical-modification-9th-revision-diagnosed-influenza-and-related-complications-in-us-children
#19
Philip O Buck, David M Smith, Rahul Shenolikar, Debra E Irwin
BACKGROUND: There is a paucity of data on the clinical and economic impact of seasonal influenza in children. This study estimated the incidence of diagnosed influenza and related complications and associated health care resource utilization and costs in US children. METHODS: Children ≥6 months and <18 years old diagnosed with influenza using International Classification of Diseases, Clinical Modification, 9th revision codes and enrolled in a health plan during at least one influenza season between 2010 and 2014 were matched to similar patients without diagnosed influenza (GSK study identifier: HO-15-15728)...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140936/increased-kawasaki-disease-incidence-associated-with-higher-precipitation-and-lower-temperatures-japan-1991-2004
#20
Joseph Y Abrams, Jennifer L Blase, Ermias B Belay, Ritei Uehara, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura
BACKGROUND: Kawasaki disease (KD) is an acute febrile vasculitis which primarily affects children. The etiology of KD is unknown: while certain characteristics of the disease suggest an infectious origin, genetic or environmental factors may also be important. Seasonal patterns of KD incidence are well-documented, but it is unclear whether these patterns are caused by changes in climate or by other unknown seasonal effects. METHODS: The relationship between KD incidence and deviations from expected temperature and precipitation were analyzed using KD incidence data from Japanese nationwide epidemiological surveys (1991-2004) and climate data from 136 weather stations of the Japan Meteorological Agency...
November 14, 2017: Pediatric Infectious Disease Journal
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