keyword
https://read.qxmd.com/read/38519646/parkin-deficiency-promotes-liver-cancer-metastasis-by-tmeff1-transcription-activation-via-tgf-%C3%AE-smad2-3-pathway
#1
JOURNAL ARTICLE
Qi Su, Jing-Jing Wang, Jia-Yan Ren, Qing Wu, Kun Chen, Kai-Hui Tu, Yu Zhang, Sze Wei Leong, Ammar Sarwar, Xu Han, Mi Zhang, Wei-Feng Dai, Yan-Min Zhang
Parkin (PARK2) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin expression is downregulated in liver cancer tissues, which correlates with poor patient survival. Parkin deficiency in liver cancer cells promotes migration and metastasis as well as changes in EMT and metastasis markers. A negative correlation exists between TMEFF1 and Parkin expression in liver cancer cells and tumor tissues. Parkin deficiency leads to upregulation of TMEFF1 which promotes migration and metastasis...
March 22, 2024: Acta Pharmacologica Sinica
https://read.qxmd.com/read/38500318/effects-of-electroacupuncture-on-mitophagy-mediated-by-sirt3-pink1-parkin-pathway-in-parkinson-s-disease-mice
#2
JOURNAL ARTICLE
Gui-Jun Zhang, Yao Wang, Jun-Ling Li, Jun Ma, Yan-Chun Wang
OBJECTIVES: To observe the effects of electroacupuncture (EA) at "Fengfu"(GV16), "Taichong"(LR3), and "Zusanli"(ST36) on mitophagy mediated by silencing regulatory protein 3 (SIRT3)/ PTEN induced putative kinase 1 (PINK1)/PARK2 gene coding protein (Parkin) in the midbrain substantia nigra of Parkinson's disease (PD) mice, and to explore the potential mechanisms of EA in treating PD. METHODS: C57BL/6 mice were randomly divided into the control, model, EA, and sham EA groups, with 12 mice in each group...
March 25, 2024: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/38488710/precise-control-of-metal-active-sites-of-metal-organic-framework-nanozymes-for-achieving-excellent-enzyme-like-activity-and-efficient-pancreatitis-therapy
#3
JOURNAL ARTICLE
Jie Zhang, Meilin Guo, Qikuan He, Zhisen Zhang, Boda Wu, Hongji Wu, Rizhao Li, Qiyu Zhang, Yonghua Tang, Youhui Lin, Yuepeng Jin
Acute pancreatitis (AP) is a potentially life-threatening inflammatory disease that can lead to the development of systemic inflammatory response syndrome and its progression to severe acute pancreatitis. Hence, there is an urgent need for the rational design of highly efficient antioxidants to treat AP. Herein, an optimized Cu-based metal-organic framework (MOF) nanozyme with exceptional antioxidant activity is introduced, designed to effectively alleviate AP, by engineering the metal coordination centers in MN2Cl2 (M = Co, Ni, Cu)...
March 15, 2024: Small
https://read.qxmd.com/read/38481992/machine-learning-and-experimental-validation-identified-autophagy-signature-in-hepatic-fibrosis
#4
JOURNAL ARTICLE
Yushen Huang, Wen Luo, Zhijie Yang, Tian Lan, Xiaomou Wei, Hongwen Wu
BACKGROUND: The molecular mechanisms of hepatic fibrosis (HF), closely related to autophagy, remain unclear. This study aimed to investigate autophagy characteristics in HF. METHODS: Gene expression profiles (GSE6764, GSE49541 and GSE84044) were downloaded, normalized, and merged. Autophagy-related differentially expressed genes (ARDEGs) were determined using the limma R package and the Wilcoxon rank sum test and then analyzed by GO, KEGG, GSEA and GSVA. The infiltration of immune cells, molecular subtypes and immune types of healthy control (HC) and HF were analyzed...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38478097/pathogenesis-of-parkinson-s-disease-from-hints-from-monogenic-familial-pd-to-biomarkers
#5
JOURNAL ARTICLE
Nobutaka Hattori, Manabu Funayama, Yuzuru Imai, Taku Hatano
Twenty-five years have passed since the causative gene for familial Parkinson's disease (PD), Parkin (now PRKN), was identified in 1998; PRKN is the most common causative gene in young-onset PD. Parkin encodes a ubiquitin-protein ligase, and Parkin is involved in mitophagy, a type of macroautophagy, in concert with PTEN-induced kinase 1 (PINK1). Both gene products are also involved in mitochondrial quality control. Among the many genetic PD-causing genes discovered, discovering PRKN as a cause of juvenile-onset PD has significantly impacted other neurodegenerative disorders...
March 13, 2024: Journal of Neural Transmission
https://read.qxmd.com/read/38319410/exploring-caenorhabditis-elegans-as-parkinson-s-disease-model-neurotoxins-and-genetic-implications
#6
REVIEW
Larissa Pereira Dantas da Silva, Erika da Cruz Guedes, Isabel Cristina Oliveira Fernandes, Lucas Aleixo Leal Pedroza, Gustavo José da Silva Pereira, Priscila Gubert
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, the first being Alzheimer's disease. Patients with PD have a loss of dopaminergic neurons in the substantia nigra of the basal ganglia, which controls voluntary movements, causing a motor impairment as a result of dopaminergic signaling impairment. Studies have shown that mutations in several genes, such as SNCA, PARK2, PINK1, DJ-1, ATP13A2, and LRRK2, and the exposure to neurotoxic agents can potentially increase the chances of PD development...
February 6, 2024: Neurotoxicity Research
https://read.qxmd.com/read/38309147/generation-of-hipscs-jucgrmi003-a-from-a-patient-with-parkinson-s-disease-with-park2-mutation
#7
JOURNAL ARTICLE
Kei-Ichi Ishikawa, Ayami Okuzumi, Hiroyo Yoshino, Nobutaka Hattori, Wado Akamatsu
PARK2 is the most common autosomal recessive form of Parkinson's disease and is caused by mutations in parkin that result in early-onset loss of dopaminergic neurons in the substantia nigra. In this study, we established an induced pluripotent stem cell (iPSC) line from a patient harboring a homozygous exon 3 deletion in PARK2. The established iPSCs showed pluripotency, the capacity to differentiate into the three germ layers, and normal karyotypes.
January 30, 2024: Stem Cell Research
https://read.qxmd.com/read/38280505/translocator-protein-tspo-ligands-attenuate-mitophagy-deficits-in-the-sh-sy5y-cellular-model-of-alzheimer-s-disease-via-the-autophagy-adaptor-p62
#8
JOURNAL ARTICLE
Lauren H Fairley, Amandine Grimm, Steffen A Herff, Anne Eckert
Mitochondrial dysfunction has been widely implicated in the pathogenesis of Alzheimer's disease (AD), with accumulation of damaged and dysfunctional mitochondria occurring early in the disease. Mitophagy, which governs mitochondrial turnover and quality control, is impaired in the AD brain, and strategies aimed at enhancing mitophagy have been identified as promising therapeutic targets. The translocator protein (TSPO) is an outer mitochondrial membrane protein that is upregulated in AD, and ligands targeting TSPO have been shown to exert neuroprotective effects in mouse models of AD...
January 25, 2024: Biochimie
https://read.qxmd.com/read/38243268/salidroside-protects-rgc-from-pyroptosis-in-diabetes-induced-retinopathy-associated-with-nlrp3-nfezl2-and-ngkb1-revealed-by-network-pharmacology-analysis-and-experimental-validation
#9
JOURNAL ARTICLE
Lan-Chun Zhang, Na Li, Min Xu, Ji-Lin Chen, Hua He, Jia Liu, Ting-Hua Wang, Zhong-Fu Zuo
OBJECTIVE: To investigate the effect of salidroside (SAL) in protecting retinal ganglion cell (RGC) from pyroptosis and explore associated molecular network mechanism in diabetic retinapathy (DR) rats. METHODS: HE, Nissl and immunofluorescence staining were used to observe the retinal morphological change, and the related target genes for salidroside, DR and pyroptosis were downloaded from GeneCard database. Then Venny, PPI, GO, KEGG analysis and molecular docking were used to reveal molecular network mechanism of SAL in inhibiting the pyroptosis of RGC...
January 20, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38225227/usp30-inhibition-induces-mitophagy-and-reduces-oxidative-stress-in-parkin-deficient-human-neurons
#10
JOURNAL ARTICLE
Justyna Okarmus, Jette Bach Agergaard, Tina C Stummann, Henriette Haukedal, Malene Ambjørn, Kristine K Freude, Karina Fog, Morten Meyer
Ubiquitination of mitochondrial proteins plays an important role in the cellular regulation of mitophagy. The E3 ubiquitin ligase parkin (encoded by PARK2) and the ubiquitin-specific protease 30 (USP30) have both been reported to regulate the ubiquitination of outer mitochondrial proteins and thereby mitophagy. Loss of E3 ligase activity is thought to be pathogenic in both sporadic and inherited Parkinson's disease (PD), with loss-of-function mutations in PARK2 being the most frequent cause of autosomal recessive PD...
January 15, 2024: Cell Death & Disease
https://read.qxmd.com/read/38224943/micrornas-correlate-with-bacillary-index-and-genes-associated-to-cell-death-processes-in-leprosy
#11
JOURNAL ARTICLE
Nadja de Lima Santana, Lucas Neves de Farias, Tainã Lago, Thyago Leal-Calvo, Paulo Roberto Lima Machado, Léa Cristina Castellucci
Mycobacterium leprae infects skin and peripheral nerves causing a broad of clinical forms. MicroRNAs (miRNAs) control immune mechanisms such as apoptosis, autophagy as well as to target genes leading to abnormal proliferation, metastasis, and invasion of cells. Herein we evaluated miRNAs expression for leprosy phenotypes in biopsies obtained from patients with and without reactions. We also correlated those miRNAs with both, bacillary index (BI) and genes involved in the micobacteria elimination process. Our results show a significant increase in the miR-125a-3p expression in paucibacillary (PB) patients vs multibacillary (MB) subjects (p = 0...
January 13, 2024: Microbes and Infection
https://read.qxmd.com/read/38181596/calcium-supplementation-attenuates-fluoride-induced-bone-injury-via-pink1-parkin-mediated-mitophagy-and-mitochondrial-apoptosis-in-mice
#12
JOURNAL ARTICLE
Yingjun Hu, Yuanyuan Li, Meng Li, Tianrui Zhao, Wenhui Zhang, Yinghui Wang, Yang He, Hui Zhao, Haojie Li, Tianyu Wang, Yangfei Zhao, Jundong Wang, Jinming Wang
Excessive consumption of fluoride can cause skeletal fluorosis. Mitophagy has been identified as a novel target for bone disorders. Meanwhile, calcium supplementation has shown great potential for mitigating fluoride-related bone damage. Hence, this study aimed to elucidate the association between mitophagy and skeletal fluorosis and the precise mechanisms through which calcium alleviates these injuries. A 100 mg/L sodium fluoride (NaF) exposure model in Parkin knockout (Parkin-/- ) mice and a 100 mg/L NaF exposure mouse model with 1% calcium carbonate (CaCO3 ) intervention were established in the current study...
January 2, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38110986/role-of-mitochondrial-fusion-proteins-mfn2-and-opa1-on-lung-cellular-senescence-in-chronic-obstructive-pulmonary-disease
#13
JOURNAL ARTICLE
Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M Adcock, Hai Zhang, Feng Li
BACKGROUND: Mitochondrial dysfunction and lung cellular senescence are significant features involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) stands as the primary contributing factor to COPD. This study examined mitochondrial dynamics, mitophagy and lung cellular senescence in COPD patients and investigated the effects of modulation of mitochondrial fusion [mitofusin2 (MFN2) and Optic atrophy 1 (OPA1)] on CS extract (CSE)-induced lung cellular senescence...
December 18, 2023: Respiratory Research
https://read.qxmd.com/read/37926948/long-read-sequencing-resolves-a-complex-structural-variant-in-prkn-parkinson-s-disease
#14
JOURNAL ARTICLE
Kensuke Daida, Manabu Funayama, Kimberley J Billingsley, Laksh Malik, Abigail Miano-Burkhardt, Hampton L Leonard, Mary B Makarious, Hirotaka Iwaki, Jinhui Ding, J Raphael Gibbs, Mayu Ishiguro, Hiroyo Yoshino, Kotaro Ogaki, Genko Oyama, Kenya Nishioka, Risa Nonaka, Wado Akamatsu, Cornelis Blauwendraat, Nobutaka Hattori
BACKGROUND: Parkin RBR E3 ubiquitin-protein ligase (PRKN) mutations are the most common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is located in FRA6E, which is one of the common fragile sites in the human genome, making this region prone to structural variants. However, complex structural variants such as inversions of PRKN are seldom reported, suggesting that there are potentially unrevealed complex pathogenic PRKN structural variants. OBJECTIVES: To identify complex structural variants in PRKN using long-read sequencing...
November 5, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/37914970/parkin-depletion-prevents-the-age-related-alterations-in-the-fgf21-system-and-the-decline-in-white-adipose-tissue-thermogenic-function-in-mice
#15
JOURNAL ARTICLE
Alejandro Delgado-Anglés, Albert Blasco-Roset, Francisco J Godoy-Nieto, Montserrat Cairó, Francesc Villarroya, Marta Giralt, Joan Villarroya
Parkin is an ubiquitin-E3 ligase that is involved in cellular mitophagy and was recently shown to contribute to controlling adipose tissue thermogenic plasticity. We found that Parkin expression is induced in brown (BAT) and white (WAT) adipose tissues of aged mice. We determined the potential role of Parkin in the aging-associated decline in the thermogenic capacity of adipose tissues by analyzing subcutaneous WAT, interscapular BAT, and systemic metabolic and physiological parameters in young (5 month-old) and aged (16 month-old) mice with targeted invalidation of the Parkin (Park2) gene, and their wild-type littermates...
November 2, 2023: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/37895852/kynurenic-acid-a-novel-player-in-cardioprotection-against-myocardial-ischemia-reperfusion-injuries
#16
JOURNAL ARTICLE
Rima Kamel, Delphine Baetz, Naïg Gueguen, Lucie Lebeau, Agnès Barbelivien, Anne-Laure Guihot, Louwana Allawa, Jean Gallet, Justine Beaumont, Michel Ovize, Daniel Henrion, Pascal Reynier, Delphine Mirebeau-Prunier, Fabrice Prunier, Sophie Tamareille
BACKGROUND: Myocardial infarction is one of the leading causes of mortality worldwide; hence, there is an urgent need to discover novel cardioprotective strategies. Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, has been previously reported to have cardioprotective effects. However, the mechanisms by which KYNA may be protective are still unclear. The current study addressed this issue by investigating KYNA's cardioprotective effect in the context of myocardial ischemia/reperfusion...
September 28, 2023: Pharmaceuticals
https://read.qxmd.com/read/37890334/generation-of-the-ipsc-line-fini002-a-from-a-male-parkinson-s-disease-patient-carrying-compound-heterozygous-mutations-in-the-prkn-gene
#17
JOURNAL ARTICLE
C Pavan, J Jin, S Jong, D Strbenac, R L Davis, C M Sue, J Johnston, T Lynch, G Halliday, D Kirik, C L Parish, L H Thompson, D A Ovchinnikov
The most common cause of autosomal recessive familial Parkinson's disease (PD) are mutations in the PRKN/PARK2 gene encoding an E3 ubiquitin protein-ligase PARKIN. We report the generation of an iPSC cell line from the fibroblasts of a male PD patient carrying a common missense variant in exon 7 (p.Arg275Trp), and a 133 kb deletion encompassing exon 8, using transiently-present Sendai virus. The established line displays typical human primed iPSC morphology and expression of pluripotency-associated markers, normal karyotype without SNP array-detectable copy number variations and can give rise to derivatives of all three embryonic germ layers...
October 17, 2023: Stem Cell Research
https://read.qxmd.com/read/37877353/parkin-regulates-igf2bp3-through-ubiquitination-in-the-tumourigenesis-of-cervical-cancer
#18
JOURNAL ARTICLE
Xin Sun, Guiqin Ye, Jiuzhou Li, Huafeng Shou, Gongxun Bai, Jianbin Zhang
BACKGROUND: Insulin-like growth Factor 2 mRNA-binding protein 3 (IGF2BP3) is a highly conserved RNA-binding protein and plays a critical role in regulating posttranscriptional modifications. METHODS: Immunoprecipitation was used to examine the interaction of Parkin and IGF2BP3. Mass spectrometry was performed to identify the ubiquitination sites of IGF2BP3. RNA-immunoprecipitation was conducted to examine the target genes of IGF2BP3. Xenograft mouse model was constructed to determine the tumorigenesis of IGF2BP3...
October 2023: Clinical and Translational Medicine
https://read.qxmd.com/read/37858629/gene-signals-and-snps-associated-with-parkinson-s-disease-a-nutrigenomics-and-computational-prospective-insights
#19
REVIEW
Swetha Subramaniyan, Beena Briget Kuriakose, Sakeena Mushfiq, Narayanaswamy Marimuthu Prabhu, Karthikeyan Muthusamy
Parkinson's disease is the most prevalent chronic neurodegenerative disease. Neurological conditions for PD were influenced by a variety of epigenetic factors and SNPs in some of the coexisting genes that were expressed. This article focused on nutrigenomics of PD and the prospective highlighting of how these genes are regulated in terms of nutritive factors and the genetic basis of PD risk, onset, and progression. Multigenetic associations of the following genetic alterations in the genes of SNCA, LRRK2, UCHL1, PARK2,PINK1, DJ-1, and ATP13A2 have been reported with the familial and de novo genetic origins of PD...
November 21, 2023: Neuroscience
https://read.qxmd.com/read/37833780/low-expression-of-pink1-and-park2-predicts-poor-prognosis-in-patients-with-esophageal-squamous-cell-carcinoma
#20
JOURNAL ARTICLE
Xiangyun Lu, Yongkun Yao, Yandi Ma, Xudong Zhang, Hao Peng, Yuhui Pei, Yulin Lu, Lianghai Wang
BACKGROUND: The Parkinson's disease (PD) gene family expression is strongly linked to tumor development and progression; PINK1 and PARK2 are essential members of the PD gene family. However, the relationship between PINK1 and PARK2 and esophageal squamous cell carcinoma (ESCC) remains unknown. This research aims to clarify the prognostic value of PINK1 and PARK2 in ESCC. METHODS: PINK1 and PARK2 protein levels in 232 ESCC specimens, and 125 matched adjacent normal tissues were detected by immunohistochemistry...
October 13, 2023: World Journal of Surgical Oncology
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