Read by QxMD icon Read

ischaemic conditionning

Derek J Hausenloy, Jose A Barrabes, Hans Erik Bøtker, Sean M Davidson, Fabio Di Lisa, James Downey, Thomas Engstrom, Péter Ferdinandy, Hector A Carbrera-Fuentes, Gerd Heusch, Borja Ibanez, Efstathios K Iliodromitis, Javier Inserte, Robert Jennings, Neena Kalia, Rajesh Kharbanda, Sandrine Lecour, Michael Marber, Tetsuji Miura, Michel Ovize, Miguel A Perez-Pinzon, Hans Michael Piper, Karin Przyklenk, Michael Rahbek Schmidt, Andrew Redington, Marisol Ruiz-Meana, Gemma Vilahur, Jakob Vinten-Johansen, Derek M Yellon, David Garcia-Dorado
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. This article provides an overview of the major topics discussed at this special meeting and underscores the huge importance and impact, the discovery of IPC has made in the field of cardiovascular research...
November 2016: Basic Research in Cardiology
Carlos Sardinero-García, Andrés Santiago-Sáez, M Del Carmen Bravo-Llatas, Bernardo Perea-Pérez, M Elena Albarrán-Juan, Elena Labajo-González, Julián Benito-León
OBJECTIVE: To analyse the sentences due to loss of chance that were passed by the Contentious-Administrative Court (i.e., in public medicine), in which both the origin of the disease to be treated and the damages were neurological. METHODS: We analysed the 90 sentences concerning neurological conditions that referred to the concept of loss of chance that were passed in Spain from 2003 (year of the first sentence) until May 2014. FINDINGS: Of the 90 sentences, 52 (57...
October 17, 2016: Gaceta Sanitaria
Christian Stoppe, Patrick Meybohm, Andreas Goetzenich
The strategy of Remote Ischaemic Conditionings (RIC) is easy to apply, cost effective, low in side effects and belongs to the most potent cardioprotective strategies evaluated within recent years. Its practical application is carried out by simple use of a blood pressure cuff, more precise by 4 repetitive cycles of inflating the cuff above 200 mmHg for 5 minutes followed by an equal long break between the cycles. First experimental and clinical data repetitively demonstrated a significant reduction in myocardial injury following ischemia/reperfusion...
October 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Mariana Moreira Coutinho Arroja, Emma Reid, Christopher McCabe
The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e. blood pressure (BP), blood volume regulation], and an independent brain RAS, which is involved in the regulation of many functions such as memory, central control of BP and metabolic functions. In general terms, the RAS consists of two opposing axes; the 'classical axis' mediated primarily by Angiotensin II (Ang II), and the 'alternative axis' mediated mainly by Angiotensin-(1-7) (Ang-(1-7))...
2016: Experimental & Translational Stroke Medicine
Monish M Maharaj, Kevin Phan, Soumya Hariswamy, Prashanth J Rao
BACKGROUND: Surfers myelopathy can be a rapidly devastating disease and little is known surrounding the pathophysiology of the condition. Although the classical pattern of illness has been well reported, it has never been observed in a non-surfing setting. METHODS: A 51-year-old demolition worker presented with acute non-traumatic myelopathy. Clinical examination revealed sensory loss to the level of L2. T2-MRI and MRI-DWI revealed a hyperintense signal suggestive of an ischaemic event...
September 2016: J Spine Surg
Jonathan D Teo, Margaret J Morris, Nicole M Jones
OBJECTIVE: In humans, maternal obesity is associated with an increase in the incidence of birth related difficulties. However, the impact of maternal obesity on the severity of brain injury in offspring is not known. Recent studies have found evidence of increased glial response and inflammatory mediators in the brains as a result of obesity in humans and rodents. We hypothesised that hypoxic-ischaemic (HI) brain injury is greater in neonatal offspring from obese rat mothers compared to lean controls...
October 13, 2016: Brain, Behavior, and Immunity
(no author information available yet)
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. METHODS: We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010...
October 8, 2016: Lancet
Marina Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L Ackland, Ana Gutierrez Del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V Gourine, Andrey Gourine
AIMS: Although the nature of the humoral factor which mediates cardioprotection established by remote ischaemic conditioning (RIc) remains unknown, parasympathetic (vagal) mechanisms appear to play a critical role. As the production and release of many gut hormones is modulated by the vagus nerve, here we tested the hypothesis that RIc cardioprotection is mediated by the actions of glucagon-like peptide-1 (GLP-1). METHODS AND RESULTS: A rat model of myocardial infarction (coronary artery occlusion followed by reperfusion) was used...
October 4, 2016: Cardiovascular Research
Nicoline Valentina Krogstrup, Mihai Oltean, Gertrude J Nieuwenhuijs-Moeke, Frank J M F Dor, Ulla Møldrup, Søren Palmelund Krag, Bo Martin Bibby, Henrik Birn, Bente Jespersen
Delayed graft function is a frequent complication following deceased donor renal transplantation, and is closely related to ischaemia-reperfusion injury. Experimental and clinical studies have shown protection by remote ischaemic conditioning (RIC). We hypothesised that recipient RIC before kidney graft reperfusion reduces the time to graft recovery. This multicentre, blinded, randomised, controlled clinical trial included 225 adult recipients of renal transplants from deceased donors at four transplantation centres in Denmark, Sweden and the Netherlands...
October 3, 2016: American Journal of Transplantation
Tobias Zander, Javier Maynar, Fernando López-Zárraga, Rogelio Herrera, Juan José Timiraos-Fernández, Andrea Saraceni, Manuel Maynar
Ischaemic stroke is a common cause of death and incapacity and is related in most cases to vascular disease. Intracranial vessel occlusion due to tumour emboli is a rare entity and adequate treatment for this condition is not defined. The use of mechanical thrombectomy devices is considered the treatment of choice for major intracranial vessel occlusion; however, no recommendation can be made in the case of tumour thrombembolia. This report describes two cases who presented with a middle cerebral artery occlusion due to tumour emboli and that were treated using the Solitaire thrombectomy device...
September 27, 2016: Interventional Neuroradiology
Céline Buffel du Vaure, Agnès Dechartres, Constance Battin, Philippe Ravaud, Isabelle Boutron
OBJECTIVES: To systematically assess registration details of ongoing randomised controlled trials (RCTs) targeting 10 common chronic conditions and registered at and to determine the prevalence of (1) trial records excluding patients with concomitant chronic condition(s) and (2) those specifically targeting patients with concomitant chronic conditions. DESIGN: Systematic review of trial registration records. DATA SOURCES: ClinicalTrials...
2016: BMJ Open
Cátia Jesus, Inês Jesus, Mark Agius
BACKGROUND: Osteoarthritis (OA) also called degenerative joint disease is the most common chronic condition of the joints that just in 2004, caused moderate to severe disability in 43.4 million of people. OA in Western populations is one of the most frequent causes of joint pain, loss of function and disability in adults. In the U.S. it is the second most common cause of work disability in men over 50 years of age, following ischaemic heart disease, and accounts for a higher number of hospitalizations when compared with rheumatoid arthritis (RA) each year...
September 2016: Psychiatria Danubina
P Cuny, M Houot, S Ginisty, S Horowicz, F Plassart, H Mentec, P Eftekhari
INTRODUCTION: The aim of this paper is to underline the need for systematic monitoring of patients treated with anticholinergic antipsychotic drugs. We present the clinical history of a 34-year-old adult, treated with quetiapine in combination with other drugs with anticholinergic effects. CASE REPORT: A 34-year-old male adult had been suffering from bipolar disorder since 2001. He was treated with risperidone, but he was not compliant due to adverse effects, including decreased libido and erectile dysfunction...
September 13, 2016: L'Encéphale
Sophie D West, Chris Turnbull
PURPOSE OF REVIEW: Obstructive sleep apnoea (OSA) is increasing in prevalence due to rising obesity. Public awareness is also growing. Although OSA is a disorder primarily of the upper airway during sleep, its physiological impact on other parts of the body is now well recognized. There is increasing interest in the association of OSA with various eye disorders. Work in this field has been directed predominantly to OSA prevalence and association studies, but some authors have tried to elucidate the effect of OSA therapies on eye diseases, including continuous positive airway pressure, upper airway surgery or bariatric surgery...
November 2016: Current Opinion in Pulmonary Medicine
Pukhraj Rishi, Neha Raka, Ekta Rishi
BACKGROUND: To study potential ischemic effects of intravitreal Bevacizumab (IVB) on unaffected retina in treatment-naive eyes with macular edema secondary to branch retinal vein occlusion (BRVO) and contralateral eyes secondary to systemic absorption. METHODS AND FINDINGS: Prospective, interventional series included 27 treatment-naive eyes with BRVO and macular edema. EXCLUSION CRITERIA: Eyes with diabetic retinopathy, glaucoma, vasculitides, papilledema or systemic neurologic condition...
2016: PloS One
Charles C Esenwa, Mitchell S Elkind
Proinflammatory conditions, including acute and chronic infections, have been associated with an increased risk of stroke. The risk of stroke is increased by both the acute and chronic phases of a wide spectrum of proinflammatory conditions, suggesting that the association is related to activation of the inflammatory response rather than the condition itself. Different inflammatory mechanisms probably influence the risk of different stroke subtypes. This hypothesis is supported by observations that high levels of various immune system markers and acute phase reactants in otherwise healthy individuals have also been associated with ischaemic stroke subtypes...
October 2016: Nature Reviews. Neurology
J A Epps, N A Smart
An emerging treatment modality for reducing damage caused by ischaemia-reperfusion injury is ischaemic conditioning. This technique induces short periods of ischaemia that have been found to protect against a more significant ischaemic insult. Remote ischaemic conditioning (RIC) can be administered more conveniently and safely, by inflation of a pneumatic blood pressure cuff to a suprasystolic pressure on a limb. Protection is then transferred to a remote organ via humoral and neural pathways. The diabetic state is particularly vulnerable to ischaemia-reperfusion injury, and ischaemia is a significant cause of many diabetic complications, including the diabetic foot...
2016: Cardiovascular Diabetology
Carlson-Babila Sama
BACKGROUND: Following digital surgical procedures, the ensuing post-operative course may be complicated by the presence of underlying ischaemic or vasospastic process. In the presence of such conditions, post-operative ischaemic changes may be further exacerbated with the use of local anaesthetics in combination with epinephrine. CASE DETAILS: We report a 21 year-old female who presented with an amputated fifth digit due to a rapidly spreading gangrene which started immediately after the surgical repair of a traumatic laceration which was infiltrated with a pre-mixed solution of lignocaine and epinephrine 3 hours earlier...
July 2016: Ethiopian Journal of Health Sciences
Ali H Mokdad, Mohammad Hossein Forouzanfar, Farah Daoud, Charbel El Bcheraoui, Maziar Moradi-Lakeh, Ibrahim Khalil, Ashkan Afshin, Marwa Tuffaha, Raghid Charara, Ryan M Barber, Joseph Wagner, Kelly Cercy, Hannah Kravitz, Matthew M Coates, Margaret Robinson, Kara Estep, Caitlyn Steiner, Sara Jaber, Ali A Mokdad, Kevin F O'Rourke, Adrienne Chew, Pauline Kim, Mohamed Magdy Abd El Razek, Safa Abdalla, Foad Abd-Allah, Jerry P Abraham, Laith J Abu-Raddad, Niveen M E Abu-Rmeileh, Abdulwahab A Al-Nehmi, Ali S Akanda, Hanan Al Ahmadi, Mazin J Al Khabouri, Faris H Al Lami, Zulfa A Al Rayess, Deena Alasfoor, Fadia S AlBuhairan, Saleh F Aldhahri, Suliman Alghnam, Samia Alhabib, Nawal Al-Hamad, Raghib Ali, Syed Danish Ali, Mohammad Alkhateeb, Mohammad A AlMazroa, Mahmoud A Alomari, Rajaa Al-Raddadi, Ubai Alsharif, Nihaya Al-Sheyab, Shirina Alsowaidi, Mohamed Al-Thani, Khalid A Altirkawi, Azmeraw T Amare, Heresh Amini, Walid Ammar, Palwasha Anwari, Hamid Asayesh, Rana Asghar, Ali M Assabri, Reza Assadi, Umar Bacha, Alaa Badawi, Talal Bakfalouni, Mohammed O Basulaiman, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Amit R Bhakta, Zulfiqar A Bhutta, Aref A Bin Abdulhak, Soufiane Boufous, Rupert R A Bourne, Hadi Danawi, Jai Das, Amare Deribew, Eric L Ding, Adnan M Durrani, Yousef Elshrek, Mohamed E Ibrahim, Babak Eshrati, Alireza Esteghamati, Imad A D Faghmous, Farshad Farzadfar, Andrea B Feigl, Seyed-Mohammad Fereshtehnejad, Irina Filip, Florian Fischer, Fortuné G Gankpé, Ibrahim Ginawi, Melkamu Dedefo Gishu, Rahul Gupta, Rami M Habash, Nima Hafezi-Nejad, Randah R Hamadeh, Hayet Hamdouni, Samer Hamidi, Hilda L Harb, Mohammad Sadegh Hassanvand, Mohammad T Hedayati, Pouria Heydarpour, Mohamed Hsairi, Abdullatif Husseini, Nader Jahanmehr, Vivekanand Jha, Jost B Jonas, Nadim E Karam, Amir Kasaeian, Nega Assefa Kassa, Anil Kaul, Yousef Khader, Shams Eldin A Khalifa, Ejaz A Khan, Gulfaraz Khan, Tawfik Khoja, Ardeshir Khosravi, Yohannes Kinfu, Barthelemy Kuate Defo, Arjun Lakshmana Balaji, Raimundas Lunevicius, Carla Makhlouf Obermeyer, Reza Malekzadeh, Morteza Mansourian, Wagner Marcenes, Habibolah Masoudi Farid, Alem Mehari, Abla Mehio-Sibai, Ziad A Memish, George A Mensah, Karzan A Mohammad, Ziad Nahas, Jamal T Nasher, Haseeb Nawaz, Chakib Nejjari, Muhammad Imran Nisar, Saad B Omer, Mahboubeh Parsaeian, Emmanuel K Peprah, Aslam Pervaiz, Farshad Pourmalek, Dima M Qato, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Rajesh K Rai, Saleem M Rana, Sowmya R Rao, Amany H Refaat, Serge Resnikoff, Gholamreza Roshandel, Georges Saade, Mohammad Y Saeedi, Mohammad Ali Sahraian, Shadi Saleh, Lidia Sanchez-Riera, Maheswar Satpathy, Sadaf G Sepanlou, Tesfaye Setegn, Amira Shaheen, Saeid Shahraz, Sara Sheikhbahaei, Kawkab Shishani, Karen Sliwa, Mohammad Tavakkoli, Abdullah S Terkawi, Olalekan A Uthman, Ronny Westerman, Mustafa Z Younis, Maysaa El Sayed Zaki, Faiez Zannad, Gregory A Roth, Haidong Wang, Mohsen Naghavi, Theo Vos, Abdullah A Al Rabeeah, Alan D Lopez, Christopher J L Murray
BACKGROUND: The eastern Mediterranean region is comprised of 22 countries: Afghanistan, Bahrain, Djibouti, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Pakistan, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, the United Arab Emirates, and Yemen. Since our Global Burden of Disease Study 2010 (GBD 2010), the region has faced unrest as a result of revolutions, wars, and the so-called Arab uprisings. The objective of this study was to present the burden of diseases, injuries, and risk factors in the eastern Mediterranean region as of 2013...
October 2016: Lancet Global Health
Allan Davies, Avedis Ekmejian, Nicholas Collins, Rohan Bhagwandeen
BACKGROUND: Percutaneous patent foramen ovale (PFO) closure is a therapeutic option to prevent recurrent cerebral ischaemia in patients with cryptogenic stroke and transient cerebral ischaemia (TIA). The apparent lack of benefit seen in previous randomised trials has, in part, reflected inclusion of patients with alternate mechanisms of stroke. The role of formal neurology involvement in accurately delineating the likely aetiology of stroke or TIA is crucial in appropriate identification of patients for device closure...
August 5, 2016: Heart, Lung & Circulation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"