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Skin barrier

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https://www.readbyqxmd.com/read/28329558/integrating-the-integrated-skin-exam-film-into-medical-education
#1
Seth Lofgreen, Michael Lehrer, Paige Bennett, Amit Garg, Cory A Dunnick
AbstractBackgroundThe mortality rate for melanoma continues to rise and the greatest improvement in melanoma survival is attributable to early detection with skin cancer screening exams. However, physicians feel that limited training in the examination of skin and limited clinical time both serve as barriers to adequately assess high-risk lesions.ObjectiveTo test the use of The Integrated Skin Exam film as an instructional tool to teach the examination of skin in a live classroom setting, outside of the purview of the original formal study...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329491/congenital-erythropoietic-porphyria-gunther-disease-long-term-follow-up-of-a-case-and-review
#2
Matthew Howard, Anthony Hall, Donald Ramsay
Patients with the rare genodermatosis congenitalerythropoietic porphyria (CEP, Gunther disease)develop erosions and scarring on sun-exposedsites caused by phototoxin mediated damage.Compromised skin barrier function places patientsat higher risk of infection and long term sequelaeinclude scarring. We report a long term follow up ofa 60 year old patient born with CEP and provide anextensive literature review of CEP including recentupdates on potential management options. Multiplepatient interviews and collection of biochemistry datawere conducted for the case discussion...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28322469/systemic-treatment-of-severe-adult-atopic-dermatitis-in-clinical-practice-analysis-of-prescribing-pattern-in-a-cohort-of-241-patients
#3
Salama Hegazy, Marie Tauber, Cristina Bulai Livideanu, Claire Uthuriague, Françoise Giordano Labadie, Marie Claude Marguery, Marie Masson Reignault, Maria Polina Konstantinou, Carle Paul
Adult Atopic dermatitis (AD) is a chronic, inflammatory skin disease which may severely impact quality of life. In patients with moderate to severe AD, major defects in skin barrier function and structure have been observed in both non lesional and lesional skin (1).Systemic treatment should be considered in patients who cannot be managed with topical therapies(2). The Guidelines do not give clear recommendations regarding which agents to use first based upon the benefits and risks of available systemic treatments(3)...
March 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28321860/nicotinamide-for-skin-cancer-chemoprevention
#4
REVIEW
Diona L Damian
Nicotinamide (vitamin B3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population...
March 20, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28321676/transdermal-delivery-of-human-growth-hormone-via-laser-generated-micropores
#5
Yang Song, Karishma Hemmady, Ashana Puri, Ajay K Banga
The epidermal skin barrier plays an important role in protecting underlying structures. It allows the passage of low molecular weight lipophilic molecules, but restricts the passage of hydrophilic molecules and macromolecules. The objective of this study was to investigate the feasibility of transdermal delivery of human growth hormone (hGH) through laser-microporated dermatomed porcine ear skin. The permeation of hGH was evaluated at different laser fluences and micropore densities. In vitro permeation studies were performed on vertical Franz diffusion cells using dermatomed porcine ear skin treated with ablative laser (2940 nm; P...
March 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28321459/-the-microbiome-and-autoimmunity
#6
T Schröder, S Ibrahim
An abundant and diverse set of commensal microbial communities covers the body's surfaces, collectively so-called microbiome. It has a functional impact on various immune processes and modulates many health-related processes, including autoimmunity. An active site of microorganism-host interplay is the intestinal mucosa. Growing evidence has helped us to learn how a specific microbiota composition and its functionality determine the intestinal barrier function and, furthermore, modulate pro-inflammatory and anti-inflammatory immune mechanisms in remote organs...
March 20, 2017: Der Internist
https://www.readbyqxmd.com/read/28320932/data-based-modeling-of-drug-penetration-relates-human-skin-barrier-function-to-the-interplay-of-diffusivity-and-free-energy-profiles
#7
Robert Schulz, Kenji Yamamoto, André Klossek, Roman Flesch, Stefan Hönzke, Fiorenza Rancan, Annika Vogt, Ulrike Blume-Peytavi, Sarah Hedtrich, Monika Schäfer-Korting, Eckart Rühl, Roland R Netz
Based on experimental concentration depth profiles of the antiinflammatory drug dexamethasone in human skin, we model the time-dependent drug penetration by the 1D general diffusion equation that accounts for spatial variations in the diffusivity and free energy. For this, we numerically invert the diffusion equation and thereby obtain the diffusivity and the free-energy profiles of the drug as a function of skin depth without further model assumptions. As the only input, drug concentration profiles derived from X-ray microscopy at three consecutive times are used...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28320495/parent-infant-skin-to-skin-contact-following-birth-history-benefits-and-challenges
#8
Jessie Marie Hubbard, Kindsey Rae Gattman
It is a practice with strong roots in nature and has a significant influence on health outcomes, particularly for at-risk newborns in low-resource settings. In this comprehensive review, benefits of SSC for newborns, mothers, and fathers after vaginal and cesarean births are discussed as well as the benefits of SSC observed for infants in the NICU. Barriers to SSC practice implementation are discussed, and proposed solutions and recommendations are offered. By understanding the many benefits of SSC and strategies for implementation, health care providers can best support and promote this high-quality, evidence-based practice with mothers, newborns, and their families...
March 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28320261/rheological-and-sensory-properties-of-hydrophilic-skin-protection-gels-based-on-polyacrylates
#9
Agnieszka Kulawik-Pióro, Joanna Kurpiewska, Agnieszka Kułaszka
INTRODUCTION: With the current increases in occupational skin diseases, literature data attesting the decreasing efficiency of barrier creams with respect to the manufacturer's declarations, and legal regulations granting skin protection gels for employees, research is required to analyse and evaluate the recipes used for hydrophilic skin protection gels based on polyacrylates. METHODS: This study investigated the rheological properties, pH, and sensory perception of hydrophilic barrier gels based on polyacrylates...
March 21, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28319313/co-creating-a-peer-education-program-to-improve-skin-health-in-older-people-from-diverse-communities-an-innovation-in-health-promotion
#10
Rajna Ogrin, Kathleen Brasher, Jessica Occleston, Jennifer Byrne
OBJECTIVE: Chronic wounds, debilitating and costly to manage, are more common in older people. Prevention is possible through improving skin health. We developed, implemented and evaluated an innovative health promotion program to improve skin health of older adults. METHODS: A one-hour, peer education program was co-created and delivered to culturally diverse community-dwelling older people. A mixed-methods evaluation approach comprised objective measures of skin health and barrier function at commencement and six weeks posteducation, and focus groups posteducation...
March 20, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/28317864/targeted-deletion-of-crif1-in-mouse-epidermis-impairs-skin-homeostasis-and-hair-morphogenesis
#11
Jung-Min Shin, Dae-Kyoung Choi, Kyung-Cheol Sohn, Ji-Young Kim, Myung Im, Young Lee, Young-Joon Seo, Minho Shong, Jeung-Hoon Lee, Chang Deok Kim
The epidermis, which consists mainly of keratinocytes, acts as a physical barrier to infections by regulating keratinocyte proliferation and differentiation. Hair follicles undergo continuous cycling to produce new one. Therefore, optimum supply of energy from the mitochondria is essential for maintaining skin homeostasis and hair growth. CRIF1 is a mitochondrial protein that regulates mitoribosome-mediated synthesis and insertion of mitochondrial oxidative phosphorylation polypeptides into the mitochondrial membrane in mammals...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303612/infant-skin-maturation-preliminary-outcomes-for-color-and-biomechanical-properties
#12
M O Visscher, S A Burkes, D M Adams, A M Hammill, R R Wickett
BACKGROUND: Newborn infant skin changes after birth but studies have focused on the epidermal barrier. Dermal properties are relevant for care, but literature on postnatal changes is sparse. We further characterized skin maturational changes in lightness, color and response to biomechanical stress. METHODS: Normal skin sites from subsets of participants in a trial on the progression and stage of infantile hemangiomas were retrospectively examined. Standardized photographs were analyzed as L*, a*, and b* images...
March 16, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28300856/halobetasol-propionate-lotion-0-05-provides-superior-hydration-compared-to-halobetasol-propionate-cream-0-05-in-a-double-blinded-study-of-occlusivity-and-hydration
#13
Gary Grove, Charles Zerweck, Tim Houser, Anthony Andrasfay, Bob Gauthier, Charles Holland, Daniel Piacquadio
BACKGROUND: This study measured skin hydration and occlusivity of two test products [halobetasol propionate lotion, 0.05% (HBP Lotion) and Ultravate® (halobetasol propionate) cream, 0.05% (HBP Cream)] at 2, 4, and 6 hours after application to skin test sites previously challenged by dry shaving, which was performed to compromise the integrity of the stratum corneum barrier. METHODS: Trans-epidermal water loss (TEWL), an indicator of skin barrier function, was measured using cyberDERM, inc...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300294/sorption-desorption-test-for-functional-assessment-of-skin-treated-with-a-lipid-system-that-mimics-epidermal-lamellar-bodies
#14
Verónica Moner, Estibalitz Fernández, Alfonso Del Pozo, Gelen Rodríguez, Mercedes Cócera, Alfonso de la Maza, Olga López
BACKGROUND: Many skin diseases are associated with either increases or decreases in lamellar body secretion, or dysfunctional lamellar bodies. Consequently, diseased skin is characterized by reduced barrier function and altered lipid composition and organization. Human skin is commonly evaluated in vivo with non-invasive biophysical techniques. The dynamic functions of the skin are evaluated with repeat measurements such as the sorption-desorption test (SDT). OBJECTIVES: The aim of this study was to evaluate in vivo skin hydration-dehydration kinetics after treatment with a lipid system that mimics the morphology, structure and composition of lamellar bodies in both healthy and irritated human skin...
March 16, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28295421/effect-of-allergens-and-irritants-on-levels-of-natural-moisturizing-factor-and-corneocyte-morphology
#15
Sjors A Koppes, Suzana Ljubojević Hadžavdić, Ivone Jakasa, Nika Franceschi, Christoph Riethmüller, Ružica Jurakić Tončic, Branka Marinovic, Nidhin Raj, Anthony V Rawlings, Rainer Voegeli, Majella E Lane, Marek Haftek, Monique H W Frings-Dresen, Thomas Rustemeyer, Sanja Kezic
BACKGROUND: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography. OBJECTIVE: To explore this phenomenon in allergic contact dermatitis. METHODS: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine...
March 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28295238/il-17-and-il-22-in-immunity-driving-protection-and-pathology
#16
REVIEW
Eyerich Kilian, Dimartino Valentina, Cavani Andrea
IL-17 and IL-22 are tissue-signaling cytokines that favor protection and regeneration of barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share cellular sources, signaling pathways, and functional aspects; however, taking a closer look they differ, e.g. in their pro-inflammatory or regenerative potential. A dysbalance of the carefully orchestrated tissue-signaling system might result in autoimmune diseases, promote cancer growth, or predispose to infectious diseases. This review highlights recent understandings in cellular sources, signaling mechanisms, physiologic as well as pathogenic role of the double-faceted cytokines IL-17 and IL-22...
March 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28293518/the-use-of-a-hyaluronic-acid-carboxymethylcellulose-membrane-as-an-adhesion-barrier-during-nipple-delay-before-nipple-preserving-mastectomy
#17
Andreas M Lamelas, Eric M Jablonka, Marco A Harmaty, Philip J Torina
The desire for nipple-preserving mastectomies has increased over the past decade as studies have proven that the procedure has comparable oncologic risk as a traditional mastectomy in both therapeutic and prophylactic cases. Partial or complete nipple necrosis is a well-known complication of this procedure with rates in the literature ranging between 1% and 9%. In high-risk patients, surgeons are performing a delay procedure before the mastectomy to help improve nipple vascularity and decrease necrosis rates...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28292894/receptor-mincle-promotes-skin-allergies-and-is-capable-of-recognizing-cholesterol-sulfate
#18
Alexey V Kostarnoy, Petya G Gancheva, Bernd Lepenies, Amir I Tukhvatulin, Alina S Dzharullaeva, Nikita B Polyakov, Daniil A Grumov, Daria A Egorova, Andrey Y Kulibin, Maxim A Bobrov, Ekaterina A Malolina, Pavel A Zykin, Andrey I Soloviev, Evgeniy Riabenko, Diana V Maltseva, Dmitry A Sakharov, Alexander G Tonevitsky, Lyudmila V Verkhovskaya, Denis Y Logunov, Boris S Naroditsky, Alexander L Gintsburg
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation; however, the underlying molecular mechanisms are not yet completely understood. Here, we show that cholesterol sulfate, a molecule present in relatively high concentrations in the epithelial layer of barrier tissues, is selectively recognized by Mincle (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in response to skin damage...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28291503/regenerative-and-antibacterial-properties-of-acellular-fish-skin-grafts-and-human-amnion-chorion-membrane-implications-for-tissue-preservation-in-combat-casualty-care
#19
Skuli Magnusson, Baldur Tumi Baldursson, Hilmar Kjartansson, Ottar Rolfsson, Gudmundur Fertram Sigurjonsson
BACKGROUND: Improvised explosive devices and new directed energy weapons are changing warfare injuries from penetrating wounds to large surface area thermal and blast injuries. Acellular fish skin is used for tissue repair and during manufacturing subjected to gentle processing compared to biologic materials derived from mammals. This is due to the absence of viral and prion disease transmission risk, preserving natural structure and composition of the fish skin graft. OBJECTIVES: The aim of this study was to assess properties of acellular fish skin relevant for severe battlefield injuries and to compare those properties with those of dehydrated human amnion/chorion membrane...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291333/metallic-state-fes-anchored-fe-fe3o4-n-doped-graphitic-carbon-with-porous-spongelike-structure-as-durable-catalysts-for-enhancing-bioelectricity-generation
#20
Xin Xu, Ying Dai, Jia Yu, Liang Hao, Yaqiang Duan, Ye Sun, Yanhong Zhang, Yuhui Lin, Jinlong Zou
The critical issues in practical application of microbial fuel cells (MFCs) for wastewater treatment are the high cost and poor activity and durability of precious metal catalysts. To alleviate the activity loss and kinetic barriers for oxygen reduction reaction (ORR) on cathode, (Fe)/Fe3O4/FeS/N-doped graphitic carbon ((Fe)/Fe3O4/FeS/NGC) is prepared as ORR catalyst through a one-step method using waste pomelo skins as carbon source. Various characterization techniques and electrochemical analyses are conducted to illustrate the correlation between structural characteristics and catalytic activity...
March 20, 2017: ACS Applied Materials & Interfaces
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