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https://www.readbyqxmd.com/read/29351893/a-clinical-decision-support-engine-based-on-a-national-medication-repository-for-the-detection-of-potential-duplicate-medications-design-and-evaluation
#1
Cheng-Yi Yang, Yu-Sheng Lo, Ray-Jade Chen, Chien-Tsai Liu
BACKGROUND: A computerized physician order entry (CPOE) system combined with a clinical decision support system can reduce duplication of medications and thus adverse drug reactions. However, without infrastructure that supports patients' integrated medication history across health care facilities nationwide, duplication of medication can still occur. In Taiwan, the National Health Insurance Administration has implemented a national medication repository and Web-based query system known as the PharmaCloud, which allows physicians to access their patients' medication records prescribed by different health care facilities across Taiwan...
January 19, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29346583/datamed-an-open-source-discovery-index-for-finding-biomedical-datasets
#2
Xiaoling Chen, Anupama E Gururaj, Burak Ozyurt, Ruiling Liu, Ergin Soysal, Trevor Cohen, Firat Tiryaki, Yueling Li, Nansu Zong, Min Jiang, Deevakar Rogith, Mandana Salimi, Hyeon-Eui Kim, Philippe Rocca-Serra, Alejandra Gonzalez-Beltran, Claudiu Farcas, Todd Johnson, Ron Margolis, George Alter, Susanna-Assunta Sansone, Ian M Fore, Lucila Ohno-Machado, Jeffrey S Grethe, Hua Xu
Objective: Finding relevant datasets is important for promoting data reuse in the biomedical domain, but it is challenging given the volume and complexity of biomedical data. Here we describe the development of an open source biomedical data discovery system called DataMed, with the goal of promoting the building of additional data indexes in the biomedical domain. Materials and Methods: DataMed, which can efficiently index and search diverse types of biomedical datasets across repositories, is developed through the National Institutes of Health-funded biomedical and healthCAre Data Discovery Index Ecosystem (bioCADDIE) consortium...
January 13, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29341288/lipid-and-nucleic-acid-chemistries-combining-the-best-of-both-worlds-to-construct-advanced-biomaterials
#3
REVIEW
Julie Baillet, Valérie Desvergnes, Aladin Hamoud, Laurent Latxague, Philippe Barthélémy
Hybrid synthetic amphiphilic biomolecules are emerging as promising supramolecular materials for biomedical and technological applications. Herein, recent progress in the field of nucleic acid based lipids is highlighted with an emphasis on their molecular design, synthesis, supramolecular properties, physicochemical behaviors, and applications in the field of health science and technology. In the first section, the design and the study of nucleolipids are in focus and then the glyconucleolipid family is discussed...
January 17, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29340148/reducing-unnecessary-culturing-a-systems-approach-to-evaluating-urine-culture-ordering-and-collection-practices-among-nurses-in-two-acute-care-settings
#4
Robert Redwood, Mary Jo Knobloch, Daniela C Pellegrini, Matthew J Ziegler, Michael Pulia, Nasia Safdar
Background: Inappropriate ordering and acquisition of urine cultures leads to unnecessary treatment of asymptomatic bacteriuria (ASB). Treatment of ASB contributes to antimicrobial resistance particularly among hospital-acquired organisms. Our objective was to investigate urine culture ordering and collection practices among nurses to identify key system-level and human factor barriers and facilitators that affect optimal ordering and collection practices. Methods: We conducted two focus groups, one with ED nurses and the other with ICU nurses...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29337877/virtual-environments-for-visualizing-structural-health-monitoring-sensor-networks-data-and-metadata
#5
Rebecca Napolitano, Anna Blyth, Branko Glisic
Visualization of sensor networks, data, and metadata is becoming one of the most pivotal aspects of the structural health monitoring (SHM) process. Without the ability to communicate efficiently and effectively between disparate groups working on a project, an SHM system can be underused, misunderstood, or even abandoned. For this reason, this work seeks to evaluate visualization techniques in the field, identify flaws in current practices, and devise a new method for visualizing and accessing SHM data and metadata in 3D...
January 16, 2018: Sensors
https://www.readbyqxmd.com/read/29334198/enzyme-based-glucose-sensor-from-invasive-to-wearable-device
#6
REVIEW
Hyunjae Lee, Yongseok Joseph Hong, Seungmin Baik, Taeghwan Hyeon, Dae-Hyeong Kim
Blood glucose concentration is a key indicator of patients' health, particularly for symptoms associated with diabetes mellitus. Because of the large number of diabetic patients, many approaches for glucose measurement have been studied to enable continuous and accurate glucose level monitoring. Among them, electrochemical analysis is prominent because it is simple and quantitative. This technology has been incorporated into commercialized and research-level devices from simple test strips to wearable devices and implantable systems...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29331057/manifestations-and-mechanisms-of-myocardial-lipotoxicity-in-obesity
#7
Arthur C Sletten, Linda R Peterson, Jean E Schaffer
Environmental and socioeconomic changes over the past thirty years have contributed to a dramatic rise in the worldwide prevalence of obesity. Heart disease is among the most serious health risks of obesity, with increases in both atherosclerotic coronary heart disease and heart failure among obese individuals. In this review, we focus on primary myocardial alterations in obesity that include hypertrophic remodeling and diastolic dysfunction. Obesity-associated perturbations in myocardial and systemic lipid metabolism are important contributors to cardiovascular complications of obesity...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29305277/amplification-of-perceived-risk-among-users-of-a-national-travel-health-web-site-during-the-2013-2016-west-african-ebola-virus-outbreak
#8
Jakob Petersen, Hilary Simons, Dipti Patel
Timely outbreak information was paramount to public health bodies issuing travel advisories during the 2013-2016 West Africa Ebola virus outbreak. This article explores the potential for a syndromic system/Shewhart control chart based on the online interaction with a national travel health Web site in comparison with searches on the Google UK search engine. The study showed an amplification of perceived risk among users of a national travel health Web site months before the World Health Organization declared the outbreak a Public Health Emergency of International Concern and the initial surge in public interest on Google UK in August 2014...
January 2, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29301314/a-tensor-based-structural-damage-identification-and-severity-assessment
#9
Ali Anaissi, Mehrisadat Makki Alamdari, Thierry Rakotoarivelo, Nguyen Lu Dang Khoa
Early damage detection is critical for a large set of global ageing infrastructure. Structural Health Monitoring systems provide a sensor-based quantitative and objective approach to continuously monitor these structures, as opposed to traditional engineering visual inspection. Analysing these sensed data is one of the major Structural Health Monitoring (SHM) challenges. This paper presents a novel algorithm to detect and assess damage in structures such as bridges. This method applies tensor analysis for data fusion and feature extraction, and further uses one-class support vector machine on this feature to detect anomalies, i...
January 2, 2018: Sensors
https://www.readbyqxmd.com/read/29300992/learning-from-high-risk-industries-may-not-be-straightforward-a-qualitative-study-of-the-hierarchy-of-risk-controls-approach-in-healthcare
#10
Elisa G Liberati, Mohammad Farhad Peerally, Mary Dixon-Woods
Objective: Though healthcare is often exhorted to learn from 'high-reliability' industries, adopting tools and techniques from those sectors may not be straightforward. We sought to examine the hierarchies of risk controls approach, used in high-risk industries to rank interventions according to supposed effectiveness in reducing risk, and widely advocated as appropriate for healthcare. Design: Classification of risk controls proposed by clinical teams following proactive detection of hazards in their clinical systems...
December 27, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29289415/insights-from-the-design-and-implementation-of-a-single-entry-model-of-referral-for-total-joint-replacement-surgery-critical-success-factors-and-unanticipated-consequences
#11
Zaheed Damani, Gail MacKean, Eric Bohm, Tom Noseworthy, Jenney Meng Han Wang, Brie DeMone, Brock Wright, Deborah A Marshall
BACKGROUND: Single-entry models (SEMs) in healthcare allow patients to see the next-available provider and have been shown to improve waiting times, access and patient flow for preference-sensitive, scheduled services. The Winnipeg Central Intake Service (WCIS) for hip and knee replacement surgery was implemented to improve access in the Winnipeg Regional Health Authority. This paper describes the system's design/implementation; successes, challenges, and unanticipated consequences. METHODS: On two occasions, during and following implementation, we interviewed all members of the WCIS project team, including processing engineers, waiting list coordinators, administrators and policy-makers regarding their experiences...
November 4, 2017: Health Policy
https://www.readbyqxmd.com/read/29283209/encapsulated-optically-responsive-cell-systems-toward-smart-implants-in-biomedicine
#12
REVIEW
Christophe Boss, Nicolas Bouche, Umberto De Marchi
Managing increasingly prevalent chronic diseases will require close continuous monitoring of patients. Cell-based biosensors may be used for implantable diagnostic systems to monitor health status. Cells are indeed natural sensors in the body. Functional cellular systems can be maintained in the body for long-term implantation using cell encapsulation technology. By taking advantage of recent progress in miniaturized optoelectronic systems, the genetic engineering of optically responsive cells may be combined with cell encapsulation to generate smart implantable cell-based sensing systems...
December 28, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29280231/a-biopsychosocial-understanding-of-lower-back-pain-content-analysis-of-online-information
#13
N M Black, S J Sullivan, R Mani
OBJECTIVES: (1) To develop a checklist to assess the representation of biopsychosocial lower back pain (LBP) online information; (2) to analyse publicly accessed online LBP information from a Google search for the degree that psychosocial contributors are described alongside the traditional biomedical approach to explaining LBP; (3) whether websites use information on pain biology to educate on LBP; (4) any inaccurate or false information regarding the mechanisms of LBP and; (5) the amount of websites certified by established benchmarks for quality health information...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29273034/data-distribution-in-public-veterinary-service-health-and-safety-challenges-push-for-context-aware-systems
#14
Laura Contalbrigo, Stefano Borgo, Giandomenico Pozza, Stefano Marangon
BACKGROUND: Today's globalised and interconnected world is characterized by intertwined and quickly evolving relationships between animals, humans and their environment and by an escalating number of accessible data for public health. The public veterinary services must exploit new modeling and decision strategies to face these changes. The organization and control of data flows have become crucial to effectively evaluate the evolution and safety concerns of a given situation in the territory...
December 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29262260/breaking-the-in-vitro-barrier-in-respiratory-medicine-engineered-microphysiological-systems-for-copd-and-beyond
#15
Kambez H Benam, Melanie Königshoff, Oliver Eickelberg
Chronic obstructive pulmonary disease (COPD) is a leading global health problem; however, our ability to understand the disease pathogenic processes and discover new pharmacotherapies have been significantly hindered due to lack of reliable model systems that are human-derived, physiologically more relevant, and can be applied predictively. Recent advances in microsystems engineering have made it possible to create biomimetic microfluidic cell culture devices, known as 'organs-on-chips'. In this Pulmonary Perspective, we discuss the emergence of 'Lung- and Small Airway-on-a-Chip' technologies and their application to recapitulate critical aspects of human lung pathophysiology, in particular COPD...
December 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29251840/blood-brain-barrier-development-systems-modeling-and-predictive-toxicology
#16
REVIEW
Katerine S Saili, Todd J Zurlinden, Andrew J Schwab, Aymeric Silvin, Nancy C Baker, E Sidney Hunter, Florent Ginhoux, Thomas B Knudsen
The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites, and hormones between vascular and neural compartments in the brain. Here, we review BBB development with regard to the microphysiology of the neurovascular unit (NVU) and the impact of BBB disruption on brain development. Our focus is on modeling these complex systems. Extant in silico models are available as tools to predict the probability of drug/chemical passage across the BBB; in vitro platforms for high-throughput screening and high-content imaging provide novel data streams for profiling chemical-biological interactions; and engineered human cell-based microphysiological systems provide empirical models with which to investigate the dynamics of NVU function...
December 1, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29239234/adoption-of-in-vitro-systems-and-zebrafish-embryos-as-alternative-models-for-reducing-rodent-use-in-assessments-of-immunological-and-oxidative-stress-responses-to-nanomaterials
#17
Helinor J Johnston, Rachel Verdon, Suzanne Gillies, David M Brown, Teresa F Fernandes, Theodore B Henry, Adriano G Rossi, Lang Tran, Carl Tucker, Charles R Tyler, Vicki Stone
Assessing the safety of engineered nanomaterials (NMs) is paramount to the responsible and sustainable development of nanotechnology, which provides huge societal benefits. Currently, there is no evidence that engineered NMs cause detrimental health effects in humans. However, investigation of NM toxicity using in vivo, in vitro, in chemico, and in silico models has demonstrated that some NMs stimulate oxidative stress and inflammation, which may lead to adverse health effects. Accordingly, investigation of these responses currently dominates NM safety assessments...
December 14, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29238926/legal-regulations-of-restrictions-of-air-pollution-made-by-non-road-mobile-machinery-the-case-study-for-europe-a-review
#18
Konrad J Waluś, Łukasz Warguła, Piotr Krawiec, Jarosław M Adamiec
The high awareness of intensification and frequency of smog phenomenon all over the world in XXI age makes for detailed analyses of the reasons of its formation and prevention. The governments of the developed countries and conscious of real hazards, including many European countries, aim to restrict the emission of harmful gases. In literature, we can find the discussions on the influence of this phenomenon on the health and life of inhabitants of contaminated areas. Some elaborations of prognostic models, descriptions of pollution sources, the manner of their restriction, and the analysis of causal-consecutive correlation are also popular...
December 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29238581/a-spicy-status-synthetic-cannabinoid-spice-use-and-new-onset-refractory-status-epilepticus-a-case-report-and-review-of-the-literature
#19
Marc-Alain Babi, Christopher P Robinson, Carolina B Maciel
Synthetic cannabinoids refer to a wide variety of chemicals engineered to bind cannabinoid receptors (CB1 and CB2) and mimic the effects of delta-9-tetrahydrocanabinol. The potential for severe toxicity and limited in vivo data make synthetic cannabinoid intake an important public health and safety concern. Neurologic toxidromes associated with their use include mental status changes, panic attacks, memory distortions, acute psychosis (e.g. paranoia, delusional thoughts), disorganized behavior, and suicidal and homicidal thoughts...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29233431/development-and-delivery-of-an-interdisciplinary-course-in-mobile-health-mhealth
#20
Brent I Fox, David A Umphress, Joshua C Hollingsworth
BACKGROUND: Interdisciplinary practice is a primary focus within the United States health care system. Despite the existence of interdisciplinary educational efforts in pharmacy for many years, the practice only recently entered mainstream health care education. Informatics offers interdisciplinary educational opportunities. Mobile health (mHealth), an informatics sub-discipline, is the use of mobile devices for health and wellness activities. We used the mHealth domain as the context for an interdisciplinary learning experience for pharmacy and computer science and software engineering (CSSE) students...
July 2017: Currents in Pharmacy Teaching & Learning
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