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https://www.readbyqxmd.com/read/29781806/the-need-for-understanding-and-engaging-the-patient-as-consumer-of-products-developed-by-neural-engineering
#1
Jennifer French, J Luis Lujan, Dawn Bardot, Emily Lauren Graczyk, Allison Hess-Dunning, Ronald J Triolo, Megan Moynahan, Winny Tan, Adeline Zbrzeski
Neural Engineering is a discipline at the intersection of neuroscience, engineering, and clinical care. Recent major efforts by government and industry aimed at bringing forth personalized therapies, increasing the potential of the neural engineering industry for future growth, eg. the National Institutes of Health (NIH) Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative and Stimulating Peripheral Activity to Relieve Conditions (SPARC) Common Fund Program, the Defense Advanced Research Projects Agency (DARPA) Electrical Prescriptions (ElectRx) and Systems-Based Neurotechnology for Emerging Therapies (SUBNETS) Programs, and the GlaxoSmithKline Bioelectric Medicines Initiative...
May 21, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29779717/the-design-and-evaluation-of-an-antimicrobial-resistance-surveillance-system-for-neonatal-intensive-care-units-in-iran
#2
Peyman Rezaei-Hachesu, Taha Samad-Soltani, Sajad Yaghoubi, Marjan GhaziSaeedi, Kayvan Mirnia, Hossein Masoumi-Asl, Reza Safdari
INTRODUCTION: Neonatal intensive care units (NICUs) have complex patients in terms of their diagnoses and required treatments. Antimicrobial treatment is a common therapy for patients in NICUs. To solve problems pertaining to empirical therapy, antimicrobial stewardship programs have recently been introduced. Despite the success of these programs in terms of data collection, there is still inefficiency in terms of analyzing and reporting the data. Thus, to successfully implement these stewardship programs, the design of antimicrobial resistance (AMR) surveillance systems is recommended as a first step...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29764617/evaluation-of-commercially-available-seat-suspensions-to-reduce-whole-body-vibration-exposures-in-mining-heavy-equipment-vehicle-operators
#3
Jeong Ho Kim, Luz S Marin, Jack T Dennerlein
As mining vehicle operators are exposed to high level of Whole body vibration (WBV) for prolonged periods of time, approaches to reduce this exposure are needed for the specific types of exposures in mining. Although various engineering controls (i.e. seat suspension systems) have been developed to address WBV, there has been lack of research to systematically evaluate these systems in reducing WBV exposures in mining heavy equipment vehicle settings. Therefore, this laboratory-based study evaluated the efficacy of different combinations of fore-aft (x-axis), lateral (y-axis), and vertical (z-axis) suspensions in reducing WBV exposures...
September 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29750783/engineering-bacterial-motility-towards-hydrogen-peroxide
#4
Chelsea Virgile, Pricila Hauk, Hsuan-Chen Wu, Wu Shang, Chen-Yu Tsao, Gregory F Payne, William E Bentley
Synthetic biologists construct innovative genetic/biological systems to treat environmental, energy, and health problems. Many systems employ rewired cells for non-native product synthesis, while a few have employed the rewired cells as 'smart' devices with programmable function. Building on the latter, we developed a genetic construct to control and direct bacterial motility towards hydrogen peroxide, one of the body's immune response signaling molecules. A motivation for this work is the creation of cells that can target and autonomously treat disease, the latter signaled by hydrogen peroxide release...
2018: PloS One
https://www.readbyqxmd.com/read/29744562/mussel-inspired-3d-fiber-scaffolds-for-heart-on-a-chip-toxicity-studies-of-engineered-nanomaterials
#5
Seungkuk Ahn, Herdeline Ann M Ardoña, Johan U Lind, Feyisayo Eweje, Sean L Kim, Grant M Gonzalez, Qihan Liu, John F Zimmerman, Georgios Pyrgiotakis, Zhenyuan Zhang, Juan Beltran-Huarac, Paul Carpinone, Brij M Moudgil, Philip Demokritou, Kevin Kit Parker
Due to the unique physicochemical properties exhibited by materials with nanoscale dimensions, there is currently a continuous increase in the number of engineered nanomaterials (ENMs) used in consumer goods. However, several reports associate ENM exposure to negative health outcomes such as cardiovascular diseases. Therefore, understanding the pathological consequences of ENM exposure represents an important challenge, requiring model systems that can provide mechanistic insights across different levels of ENM-based toxicity...
May 10, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29743083/policy-environment-for-prevention-control-and-management-of-cardiovascular-diseases-in-primary-health-care-in-kenya
#6
Gershim Asiki, Shuai Shao, Carol Wainana, Christopher Khayeka-Wandabwa, Tilahun N Haregu, Pamela A Juma, Shukri Mohammed, David Wambui, Enying Gong, Lijing L Yan, Catherine Kyobutungi
BACKGROUND: In Kenya, cardiovascular diseases (CVDs) accounted for more than 10% of total deaths and 4% of total Disability-Adjusted Life Years (DALYs) in 2015 with a steady increase over the past decade. The main objective of this paper was to review the existing policies and their content in relation to prevention, control and management of CVDs at primary health care (PHC) level in Kenya. METHODS: A targeted document search in Google engine using keywords "Kenya national policy on cardiovascular diseases" and "Kenya national policy on non-communicable diseases (NCDs)" was conducted in addition to key informant interviews with Kenyan policy makers...
May 9, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29737418/towards-a-clinical-trial-protocol-to-evaluate-health-information-systems-evaluation-of-a-computerized-system-for-monitoring-tuberculosis-from-a-patient-perspective-in-brazil
#7
Nathalia Yukie Crepaldi, Inacia Bezerra de Lima, Fernanda Bergamini Vicentine, Lídia Maria Lourençon Rodrigues, Tiago Lara Michelin Sanches, Antonio Ruffino-Netto, Domingos Alves, Rui Pedro Charters Lopes Rijo
Assessment of health information systems consider different aspects of the system itself. They focus or on the professional who will use the software or on its usability or on the software engineering metrics or on financial and managerial issues. The existent approaches are very resources consuming, disconnected, and not standardized. As the software becomes more critical in the health organizations and in patients, becoming used as a medical device or a medicine, there is an urgency to identify tools and methods that can be applied in the development process...
May 8, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29736579/combination-of-polymeric-supports-and-drug-delivery-systems-for-osteochondral-regeneration
#8
Luis Rojo
Musculoskeletal conditions have been defined by European National Health systems as one of the key themes which should be featured during the present decade as a consequence of the significant healthcare and social support costs. Among others, articular cartilage degeneration due to traumatic and degenerative lesion injury or other pathologies commonly results in the development of musculoskeletal disorders such as osteoarthritis and arthritis rheumatoid, eventually leading to progressive articular cartilage and joint destruction especially at osteochondral interphase, that account for more disability among the elderly than any other diseases constituting a global social challenge that needs a multidisciplinary response from the scientific community...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29735477/finding-meaning-in-medication-reconciliation-using-electronic-health-records-qualitative-analysis-in-safety-net-primary-and-specialty-care
#9
George Yaccoub Matta, Elaine C Khoong, Courtney R Lyles, Dean Schillinger, Neda Ratanawongsa
BACKGROUND: Safety net health systems face barriers to effective ambulatory medication reconciliation for vulnerable populations. Although some electronic health record (EHR) systems offer safety advantages, EHR use may affect the quality of patient-provider communication. OBJECTIVE: This mixed-methods observational study aimed to develop a conceptual framework of how clinicians balance the demands and risks of EHR and communication tasks during medication reconciliation discussions in a safety net system...
May 7, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29734625/organic-contaminants-in-african-aquatic-systems-current-knowledge-health-risks-and-future-research-directions
#10
REVIEW
Willis Gwenzi, Nhamo Chaukura
Organic contaminants (OCs) are increasingly being reported in African aquatic systems, yet a critical evaluation of the literature is still lacking. The objectives of this review were to: (1) identify hotspot reservoirs, transfer pathways and ecological and human risks of OCs, (2) identify potential interventions to minimize the health risks, and (3) highlight knowledge gaps and research constraints. OCs widely reported in aquatic systems include pesticides, pharmaceuticals, plasticizers, solvents, endocrine disrupting compounds, and antimicrobial resistance genes, originating from applications in crop protection, veterinary and animal husbandry, human sanitation and hygiene, human vector and disease control...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29733891/-connecting-worlds-a-view-on-microfluidics-for-a-wider-application
#11
REVIEW
Ana C Fernandes, Krist V Gernaey, Ulrich Krühne
From its birth, microfluidics has been referenced as a revolutionary technology and the solution to long standing technological and sociological issues, such as detection of dilute compounds and personalized healthcare. Microfluidics has for example been envisioned as: (1) being capable of miniaturizing industrial production plants, thereby increasing their automation and operational safety at low cost; (2) being able to identify rare diseases by running bioanalytics directly on the patient's skin; (3) allowing health diagnostics in point-of-care sites through cheap lab-on-a-chip devices...
May 4, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29731775/three-dimensional-bioreactor-technologies-for-the-cocultivation-of-human-mesenchymal-stem-stromal-cells-and-beta-cells
#12
REVIEW
Florian Petry, Tobias Weidner, Peter Czermak, Denise Salzig
Diabetes is a prominent health problem caused by the failure of pancreatic beta cells. One therapeutic approach is the transplantation of functional beta cells, but it is difficult to generate sufficient beta cells in vitro and to ensure these cells remain viable at the transplantation site. Beta cells suffer from hypoxia, undergo apoptosis, or are attacked by the host immune system. Human mesenchymal stem/stromal cells (hMSCs) can improve the functionality and survival of beta cells in vivo and in vitro due to direct cell contact or the secretion of trophic factors...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29721362/career-paths-of-pathology-informatics-fellowship-alumni
#13
Joseph W Rudolf, Christopher A Garcia, Matthew G Hanna, Christopher L Williams, Ulysses G Balis, Liron Pantanowitz, J Mark Tuthill, John R Gilbertson
Background: The alumni of today's Pathology Informatics and Clinical Informatics fellowships fill diverse roles in academia, large health systems, and industry. The evolving training tracks and curriculum of Pathology Informatics fellowships have been well documented. However, less attention has been given to the posttraining experiences of graduates from informatics training programs. Here, we examine the career paths of subspecialty fellowship-trained pathology informaticians. Methods: Alumni from four Pathology Informatics fellowship training programs were contacted for their voluntary participation in the study...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29709837/ultrafine-particle-emissions-from-modern-gasoline-and-diesel-vehicles-an-electron-microscopic-perspective
#14
Anthi Liati, Daniel Schreiber, Yadira Arroyo Rojas Dasilva, Panayotis Dimopoulos Eggenschwiler
Ultrafine (<100 nm) particles related to traffic are of high environmental and human health concern, as they are supposed to be more toxic than larger particles. In the present study transmission electron microscopy (TEM) is applied to obtain a concrete picture on the nature, morphology and chemical composition of non-volatile ultrafine particles in the exhaust of state-of-the-art, Euro 6b, Gasoline and Diesel vehicles. The particles were collected directly on TEM grids, at the tailpipe, downstream of the after-treatment system, during the entire duration of typical driving cycles on the chassis dynamometer...
April 27, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29708973/calibration-and-testing-of-a-raman-hyperspectral-imaging-system-to-reveal-powdered-food-adulteration
#15
Santosh Lohumi, Hoonsoo Lee, Moon S Kim, Jianwei Qin, Lalit Mohan Kandpal, Hyungjin Bae, Anisur Rahman, Byoung-Kwan Cho
The potential adulteration of foodstuffs has led to increasing concern regarding food safety and security, in particular for powdered food products where cheap ground materials or hazardous chemicals can be added to increase the quantity of powder or to obtain the desired aesthetic quality. Due to the resulting potential health threat to consumers, the development of a fast, label-free, and non-invasive technique for the detection of adulteration over a wide range of food products is necessary. We therefore report the development of a rapid Raman hyperspectral imaging technique for the detection of food adulteration and for authenticity analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29707389/making-ward-based-outreach-teams-an-effective-component-of-human-immunodeficiency-virus-programmes-in-south-africa
#16
Nireshni Naidoo, Jean Railton, Geoffrey Jobson, Nthabiseng Matlakala, Gert Marincowitz, James A McIntyre, Helen E Struthers, Remco P H Peters
The implementation of ward-based outreach teams (WBOTs), comprised of community health workers (CHWs), is one of the three interventions of the South African National Department of Health's (NDoH) Primary Health Care (PHC) Re-engineering strategy for improving health outcomes. CHWs provide a necessary structure to contribute to successful implementation of the human immunodeficiency virus (HIV) programme in four ways: (1) prevention of HIV infection by health education, (2) linkage to care by health education and referrals, (3) adherence support and (4) identification of individuals who are failing treatment...
2018: Southern African Journal of HIV Medicine
https://www.readbyqxmd.com/read/29707260/can-composite-digital-monitoring-biomarkers-come-of-age-a-framework-for-utilization
#17
REVIEW
Christopher Kovalchick, Rhea Sirkar, Oliver B Regele, Lampros C Kourtis, Marie Schiller, Howard Wolpert, Rhett G Alden, Graham B Jones, Justin M Wright
Introduction: The application of digital monitoring biomarkers in health, wellness and disease management is reviewed. Harnessing the near limitless capacity of these approaches in the managed healthcare continuum will benefit from a systems-based architecture which presents data quality, quantity, and ease of capture within a decision-making dashboard. Methods: A framework was developed which stratifies key components and advances the concept of contextualized biomarkers...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29704465/association-of-manual-or-engine-driven-glide-path-preparation-with-canal-centring-and-apical-transportation-a-systematic-review
#18
REVIEW
R C Hartmann, O A Peters, Jap de Figueiredo, G Rossi-Fedele
The role and effect of glide path preparation in root canal treatment remains controversial. This systematic review aims to compare apical transportation and canal centring of different glide path preparation techniques, with or without subsequent engine-driven root canal preparation. A database search in PubMed, PubMed Central, Embase, Scopus, EBSCO Dentistry & Oral Sciences Source and Virtual Health Library was conducted, using appropriate key words to identify the effect of glide path preparation (or its absence) on apical transportation and canal centring...
April 28, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29699013/-investigation-and-analysis-on-shift-work-female-workers-and-the-impact-on-reproductive-health
#19
C Y Yu, W L Yu, M Xu, Z L Xing
Objective: To investigate the distribution of shift work of female workers in different industries and the relationship between shift work and reproductive health, then provide reference for the female workers' labor protection. Methods: From June to September 2016, cluster sampling questionnaire survey was performed among female workers from 11 industries including electronics, medicine and health, pharmacy. To investigate the general information, shift - work information, reproductive health and childbearing history of these female workers...
February 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29697971/lifetime-encoded-infrared-emitting-nanoparticles-for-in-vivo-multiplexed-imaging
#20
Dirk H Ortgies, Meiling Tan, Erving C Ximendes, Blanca Del Rosal, Jie Hu, Lei Xu, Xindong Wang, Emma Martin Rodriguez, Carlos Jacinto, Nuria Fernandez, Guanying Chen, Daniel Jaque
Advanced diagnostic procedures are required to satisfy the continuously increasing demands of modern biomedicine while also addressing the need for cost reduction in public health systems. The development of infrared luminescence-based techniques for in vivo imaging is emerging as a reliable alternative to traditional imaging techniques, applicable with simpler and more cost-effective apparatus. In order to further improve the information provided by in vivo luminescence images, the design and fabrication of enhanced infrared-luminescent contrast agents is required...
April 26, 2018: ACS Nano
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