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https://www.readbyqxmd.com/read/28206693/plasmid-and-clonal-interference-during-post-horizontal-gene-transfer-evolution
#1
S Bedhomme, D Perez Pantoja, I G Bravo
Plasmids are nucleic acid molecules that can drive their own replication in a living cell. They can be transmitted horizontally and can thrive in the host cell to high copy numbers. Plasmid replication and gene expression consume cellular resources and cells carrying plasmids incur fitness costs. But many plasmids carry genes that can be beneficial under certain conditions, allowing the cell to endure in the presence of antibiotics, toxins, competitors or parasites. Horizontal transfer of plasmid-encoded genes can thus instantaneously confer differential adaptation to local or transient selection conditions...
February 16, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28186074/adoption-of-electronic-health-record-system-in-community-based-physiotherapy-clinics-a-pilot-case-study
#2
Alan Yung
QUESTION: Can community-based physiotherapists adopt and use a nationally integrated electronic health record (NEHR) system? DESIGN: Observation and semi-structured interviews in two community-based physiotherapy clinics in Sydney, Australia. PARTICIPANTS: Two physiotherapy practice managers who were also practising physiotherapists. INTERVENTION: The implementation of a nationally integrated EHR system in physiotherapy...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28185593/decentralization-and-health-system-performance-a-focused-review-of-dimensions-difficulties-and-derivatives-in-india
#3
REVIEW
Bhuputra Panda, Harshad P Thakur
INTRODUCTION: One of the principal goals of any health care system is to improve health through the provision of clinical and public health services. Decentralization as a reform measure aims to improve inputs, management processes and health outcomes, and has political, administrative and financial connotations. It is argued that the robustness of a health system in achieving desirable outcomes is contingent upon the width and depth of 'decision space' at the local level. Studies have used different approaches to examine one or more facets of decentralization and its effect on health system functioning; however, lack of consensus on an acceptable framework is a critical gap in determining its quantum and quality...
October 31, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28184986/recent-advances-in-genetic-modification-systems-for-actinobacteria
#4
REVIEW
Yu Deng, Xi Zhang, Xiaojuan Zhang
Actinobacteria are extremely important to human health, agriculture, and forests. Because of the vast differences of the characteristics of Actinobacteria, a lot of genetic tools have been developed for efficiently manipulating the genetics. Although there are a lot of successful examples of engineering Actinobacteria, they are still more difficult to be genetically manipulated than other model microorganisms such as Saccharomyces cerevisiae, Escherichia coli, and Bacillus subtilis etc. due to the diverse genomics and biochemical machinery...
February 9, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28182692/aircraft-engine-sensor-fault-diagnostics-using-an-on-line-obem-update-method
#5
Xiaofeng Liu, Naiyu Xue, Ye Yuan
This paper proposed a method to update the on-line health reference baseline of the On-Board Engine Model (OBEM) to maintain the effectiveness of an in-flight aircraft sensor Fault Detection and Isolation (FDI) system, in which a Hybrid Kalman Filter (HKF) was incorporated. Generated from a rapid in-flight engine degradation, a large health condition mismatch between the engine and the OBEM can corrupt the performance of the FDI. Therefore, it is necessary to update the OBEM online when a rapid degradation occurs, but the FDI system will lose estimation accuracy if the estimation and update are running simultaneously...
2017: PloS One
https://www.readbyqxmd.com/read/28179154/managing-the-patient-identification-crisis-in-healthcare-and-laboratory-medicine
#6
REVIEW
Giuseppe Lippi, Camilla Mattiuzzi, Chiara Bovo, Emmanuel J Favaloro
Identification errors have emerged as a critical issue in health care, as testified by the ample scientific literature on this argument. Despite available evidence suggesting that the frequency of misidentification in vitro laboratory diagnostic testing may be relatively low compared to that of other laboratory errors (i.e., usually comprised between 0.01 and 0.1% of all specimens received), the potential adverse consequences remain particularly worrying, wherein 10-20% of these errors not only would translate into serious harm for the patient, but may also erode considerable human and economic resources, so that the entire healthcare system should be re-engineered to act proactively and limiting the burden of this important problem...
February 5, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28179044/translating-battlefield-practices-to-disaster-health
#7
Kandra Strauss-Riggs, Kevin Yeskey, Aubrey Miller, Stacey Arnesen, Craig Goolsby
We review aspects of the recently released National Academies of Sciences, Engineering, and Medicine report A National Trauma Care System: Integrating Military and Civilian Trauma Systems to Achieve Zero Preventable Deaths After Injury most relevant to disaster health, particularly the concepts of focused empiricism and building a learning health system. The article references battlefield success utilizing these concepts and the emerging Disaster Research Response Program. We call upon disaster health researchers to apply the report's recommendations to their work...
February 9, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28169129/adapting-a-psychosocial-intervention-for-smartphone-delivery-to-middle-aged-and-older-adults-with-serious-mental-illness
#8
Karen L Whiteman, Matthew C Lohman, Lydia E Gill, Martha L Bruce, Stephen J Bartels
OBJECTIVE: To describe the process of adapting an integrated medical and psychiatric self-management intervention to a smartphone application for middle-aged and older adults with serious mental illness using an adaptive systems engineering framework and user-centered design. METHODS: First, we determined the technical abilities and needs of middle-aged and older adults with serious mental illnesses using smartphones. Then, we developed smartphone content through principles of user-centered design and modified an existing smartphone platform...
January 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28168876/characterization-of-stilbene-synthase-genes-in-mulberry-morus-atropurpurea-and-metabolic-engineering-for-the-production-of-resveratrol-in-escherichia-coli
#9
Chuanhong Wang, Shuang Zhi, Changying Liu, Fengxiang Xu, Ai Chun Zhao, Xiling Wang, Yanhong Ren, Zhengang Li, Maode Yu
Stilbenes have been recognized for their beneficial physiological effects on human health. Stilbene synthase (STS) is the key enzyme of resveratrol biosynthesis and has been studied in numerous plants. Here, four MaSTS genes were isolated and identified in mulberry (Morus atropurpurea Roxb.). The expression levels of MaSTS genes and the accumulation of trans-resveratrol, trans-oxyresveratrol and trans-mulberroside A were investigated in different plant organs. A novel co-expression system that harbored 4-coumarate:CoA ligase gene (Ma4CL) and MaSTS was established...
February 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28168668/systems-biology-to-support-nanomaterial-grouping
#10
Christian Riebeling, Harald Jungnickel, Andreas Luch, Andrea Haase
The assessment of potential health risks of engineered nanomaterials (ENMs) is a challenging task due to the high number and great variety of already existing and newly emerging ENMs. Reliable grouping or categorization of ENMs with respect to hazards could help to facilitate prioritization and decision making for regulatory purposes. The development of grouping criteria, however, requires a broad and comprehensive data basis. A promising platform addressing this challenge is the systems biology approach. The different areas of systems biology, most prominently transcriptomics, proteomics and metabolomics, each of which provide a wealth of data that can be used to reveal novel biomarkers and biological pathways involved in the mode-of-action of ENMs...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28166883/seips-based-process-modeling-in-primary-care
#11
Abigail R Wooldridge, Pascale Carayon, Ann Schoofs Hundt, Peter L T Hoonakker
Process mapping, often used as part of the human factors and systems engineering approach to improve care delivery and outcomes, should be expanded to represent the complex, interconnected sociotechnical aspects of health care. Here, we propose a new sociotechnical process modeling method to describe and evaluate processes, using the SEIPS model as the conceptual framework. The method produces a process map and supplementary table, which identify work system barriers and facilitators. In this paper, we present a case study applying this method to three primary care processes...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28163918/health-system-performance-assessment-landscape-at-the-eu-level-a-structured-synthesis-of-actors-and-actions
#12
Nataša Perić, Maria M Hofmarcher-Holzhacker, Judit Simon
BACKGROUND: Many policy makers and other stakeholders in the EU have expressed interest in better understanding the performance of their own health systems to identify opportunities for improvement in effectiveness, efficiency and equity. Health system performance assessment (HSPA) has received considerable attention at EU level as an instrument to improve transparency and accountability. This is equally important for population health and sustainable health spending. The goal of this paper is to synthesise and map the current state and developments in the field of HSPA relevant in the EU context and by this aid the navigation in the growing HSPA system, understand the available tools and identify opportunities for improvement...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28162030/infodemiology-of-systemic-lupus-erythematous-using-google-trends
#13
M Radin, S Sciascia
Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. 'Infodemiology' and 'infoveillance' are two recent terms created to describe a new developing approach for public health, based on Big Data monitoring and data mining. In this study, we aim to investigate trends of Internet research linked to SLE and symptoms associated with the disease, applying a Big Data monitoring approach...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28160172/arsenic-uptake-accumulation-and-toxicity-in-rice-plants-possible-remedies-for-its-detoxification-a-review
#14
Hafiz Faiq Bakhat, Zahida Zia, Shah Fahad, Sunaina Abbas, Hafiz Mohkum Hammad, Ahmad Naeem Shahzad, Farhat Abbas, Hesham Alharby, Muhammad Shahid
Arsenic (As) is a toxic metalloid. Serious concerns have been raised in literature owing to its potential toxicity towards living beings. The metalloid causes various water- and food-borne diseases. Among food crops, rice contains the highest concentrations of As. Consuming As-contaminated rice results in serious health issues. Arsenic concentration in rice is governed by various factors in the rhizosphere such as availability and concentration of various mineral nutrients (iron, phosphate, sulfur and silicon) in soil solution, soil oxidation/reduction status, inter-conversion between organic and inorganic As compounds...
February 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28145266/the-pipeline-of-physiology-courses-in-community-colleges-to-university-medical-school-and-beyond
#15
REVIEW
Jenny McFarland, Pamela Pape-Lindstrom
Community colleges are significant in the landscape of undergraduate STEM (science technology, engineering, and mathematics) education (9), including biology, premedical, and other preprofessional education. Thirty percent of first-year medical school students in 2012 attended a community college. Students attend at different times in high school, their first 2 yr of college, and postbaccalaureate. The community college pathway is particularly important for traditionally underrepresented groups. Premedical students who first attend community college are more likely to practice in underserved communities (2)...
December 2016: Advances in Physiology Education
https://www.readbyqxmd.com/read/28144608/the-current-perspectives-of-stem-cell-therapy-in-orthopedic-surgery
#16
REVIEW
Serkan Akpancar, Oner Tatar, Hasan Turgut, Faruk Akyildiz, Safak Ekinci
CONTEXT: Musculoskeletal injuries may be painful, troublesome, life limiting and also one of the global health problems. There has been considerable amount of interest during the past two decades to stem cells and tissue engineering techniques in orthopedic surgery, especially to manage special and compulsive injuries within the musculoskeletal system. EVIDENCE ACQUISITION: The aim of this study was to present a literature review regarding the most recent progress in stem cell procedures and current indications in orthopedics clinical care practice...
December 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/28133586/possible-health-impacts-of-bt-toxins-and-residues-from-spraying-with-complementary-herbicides-in-genetically-engineered-soybeans-and-risk-assessment-as-performed-by-the-european-food-safety-authority-efsa
#17
REVIEW
Christoph Then, Andreas Bauer-Panskus
BACKGROUND: MON89788 was the first genetically engineered soybean worldwide to express a Bt toxin. Under the brand name Intacta, Monsanto subsequently engineered a stacked trait soybean using MON89788 and MON87701-this stacked soybean expresses an insecticidal toxin and is, in addition, tolerant to glyphosate. After undergoing risk assessment by the European Food Safety Authority (EFSA), the stacked event was authorised for import into the EU in June 2012, including for use in food and feed...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28131722/development-and-empirical-user-centered-evaluation-of-semantically-based-query-recommendation-for-an-electronic-health-record-search-engine
#18
David A Hanauer, Danny T Y Wu, Lei Yang, Qiaozhu Mei, Katherine B Murkowski-Steffy, V G Vinod Vydiswaran, Kai Zheng
OBJECTIVE: The utility of biomedical information retrieval environments can be severely limited when users lack expertise in constructing effective search queries. To address this issue, we developed a computer-based query recommendation algorithm that suggests semantically interchangeable terms based on an initial user-entered query. In this study, we assessed the value of this approach, which has broad applicability in biomedical information retrieval, by demonstrating its application as part of a search engine that facilitates retrieval of information from electronic health records (EHRs)...
January 25, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28126605/cognitive-engineering-and-health-informatics-applications-and-intersections
#19
A Zachary Hettinger, Emilie Roth, Ann M Bisantz
Cognitive engineering is an applied field with roots in both cognitive science and engineering that has been used to support design of information displays, decision support, human-automation interaction, and training in numerous high risk domains ranging from nuclear power plant control to transportation and defense systems. Cognitive engineering provides a set of structured, analytic methods for data collection and analysis that intersect with and complement methods of Cognitive Informatics. These methods support discovery of aspects of the work that make performance challenging, as well as the knowledge, skills, and strategies that experts use to meet those challenges...
January 23, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28126242/artificial-intelligence-in-medicine
#20
Pavel Hamet, Johanne Tremblay
Artificial Intelligence (AI) is a general term that implies the use of a computer to model intelligent behavior with minimal human intervention. AI is generally accepted as having started with the invention of robots. The term derives from the Czech word robota, meaning biosynthetic machines used as forced labor. In this field, Leonardo Da Vinci's lasting heritage is today's burgeoning use of robotic-assisted surgery, named after him, for complex urologic and gynecologic procedures. Da Vinci's sketchbooks of robots helped set the stage for this innovation...
January 11, 2017: Metabolism: Clinical and Experimental
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