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https://www.readbyqxmd.com/read/28727079/detection-of-dietary-dna-protein-and-glyphosate-in-meat-milk-and-eggs
#1
A L Van Eenennaam, A E Young
Products such as meat, milk, and eggs from animals that have consumed genetically engineered (GE) feed are not currently subject to mandatory GE labeling requirements. Some voluntary "non-genetically modified organism" labeling has been associated with such products, indicating that the animals were not fed GE crops, as there are no commercialized GE food animals. This review summarizes the available scientific literature on the detection of dietary DNA and protein in animal products and briefly discusses the implications of mandatory GE labeling for products from animals that have consumed GE feed...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726971/an-environment-for-guideline-based-decision-support-systems-for%C3%A2-outpatients-monitoring
#2
Elisa M Zini, Giordano Lanzola, Paolo Bossi, Silvana Quaglini
OBJECTIVES: We propose an architecture for monitoring outpatients that relies on mobile technologies for acquiring data. The goal is to better control the onset of possible side effects between the scheduled visits at the clinic. METHODS: We analyze the architectural components required to ensure a high level of abstraction from data. Clinical practice guidelines were formalized with Alium, an authoring tool based on the PROforma language, using SNOMED-CT as a terminology standard...
July 19, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28714927/development-and-application-of-a-structural-health-monitoring-system-based-on-wireless-smart-aggregates
#3
Shi Yan, Haoyan Ma, Peng Li, Gangbing Song, Jianxin Wu
Structural health monitoring (SHM) systems can improve the safety and reliability of structures, reduce maintenance costs, and extend service life. Research on concrete SHMs using piezoelectric-based smart aggregates have reached great achievements. However, the newly developed techniques have not been widely applied in practical engineering, largely due to the wiring problems associated with large-scale structural health monitoring. The cumbersome wiring requires much material and labor work, and more importantly, the associated maintenance work is also very heavy...
July 17, 2017: Sensors
https://www.readbyqxmd.com/read/28709963/animal-models-of-biliary-injury-and-altered-bile-acid-metabolism
#4
REVIEW
Valeria Mariotti, Mario Strazzabosco, Luca Fabris, Diego F Calvisi
In the last 25years, a number of animal models, mainly rodents, have been generated with the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the mechanisms of biliary repair and, eventually, to test the efficacy of innovative treatments. Despite fundamental limitations applying to these models, such as the distinct immune system and the different metabolism regulating liver homeostasis in rodents when compared to humans, multiple approaches, such as surgery (bile duct ligation), chemical-induced (3,5-diethoxycarbonyl-1,4-dihydrocollidine, DDC, α-naphthylisothiocyanate, ANIT), viral infections (Rhesus rotavirustype A, RRV-A), and genetic manipulation (Mdr2, Cftr, Pkd1, Pkd2, Prkcsh, Sec63, Pkhd1) have been developed...
July 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28707470/enhancement-of-naringenin-biosynthesis-from-tyrosine-by-metabolic-engineering-of-saccharomyces-cerevisiae
#5
Xiaomei Lyu, Kuan Rei Ng, Jie Lin Lee, Rita Mark, Wei Ning Chen
Flavonoids are a class of plant polyphenols that possess a variety of essential health properties. In this work, the capacity of microbial naringenin synthesis from tyrosine in S. cerevisiae was explored and optimized through metabolic engineering on precursor supply and promoter control within three modules. Specifically, in Module 1, a modified GAL system was employed for pathway construction and the synergistic action of constituent genes was investigated for yield improvement. In Module 2, the effect of malonyl-CoA supply on fatty acid/naringenin production was explored through up-regulation of acetyl-CoA production and down-regulation of fatty acid biosynthesis...
July 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28705788/how-do-clinicians-learn-about-knowledge-translation-an-investigation-of-current-web-based-learning-opportunities
#6
Raechel A Damarell, Jennifer J Tieman
BACKGROUND: Clinicians are important stakeholders in the translation of well-designed research evidence into clinical practice for optimal patient care. However, the application of knowledge translation (KT) theories and processes may present conceptual and practical challenges for clinicians. Online learning platforms are an effective means of delivering KT education, providing an interactive, time-efficient, and affordable alternative to face-to-face education programs. OBJECTIVE: This study investigates the availability and accessibility of online KT learning opportunities for health professionals...
July 13, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/28705224/more-than-just-a-gut-feeling-constraint-based-genome-scale-metabolic-models-for-predicting-functions-of-human-intestinal-microbes
#7
REVIEW
Kees C H van der Ark, Ruben G A van Heck, Vitor A P Martins Dos Santos, Clara Belzer, Willem M de Vos
The human gut is colonized with a myriad of microbes, with substantial interpersonal variation. This complex ecosystem is an integral part of the gastrointestinal tract and plays a major role in the maintenance of homeostasis. Its dysfunction has been correlated to a wide array of diseases, but the understanding of causal mechanisms is hampered by the limited amount of cultured microbes, poor understanding of phenotypes, and the limited knowledge about interspecies interactions. Genome-scale metabolic models (GEMs) have been used in many different fields, ranging from metabolic engineering to the prediction of interspecies interactions...
July 14, 2017: Microbiome
https://www.readbyqxmd.com/read/28700955/liver-specific-gene-immunotherapies-resolve-immune-suppressive-ectopic-lymphoid-structures-of-liver-metastases-and-prolong-survival
#8
Tyler J Goodwin, Limei Shen, Mengying Hu, Jingjing Li, Richard Feng, Oleksandra Dorosheva, Rihe Liu, Leaf Huang
The ability to generate potent immunotherapies locally and transiently for the treatment of cancers is a promising strategy to improve efficacy and decrease off-target toxicities. Here, we explored an alternative approach for the delivery of immunotherapeutic agents, in which we deliver the pDNA of an engineered PD-L1 trap and/or CXCL12 trap to the nucleus of liver hepatocytes via a lipid calcium phosphate nanoparticle. This strategy greatly increased the concentrations of immunotherapeutic agents in the local tissue, allowing the therapy to inhibit the accumulation of immune suppressive cells and liver metastasis...
July 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28699566/entity-recognition-from-clinical-texts-via-recurrent-neural-network
#9
Zengjian Liu, Ming Yang, Xiaolong Wang, Qingcai Chen, Buzhou Tang, Zhe Wang, Hua Xu
BACKGROUND: Entity recognition is one of the most primary steps for text analysis and has long attracted considerable attention from researchers. In the clinical domain, various types of entities, such as clinical entities and protected health information (PHI), widely exist in clinical texts. Recognizing these entities has become a hot topic in clinical natural language processing (NLP), and a large number of traditional machine learning methods, such as support vector machine and conditional random field, have been deployed to recognize entities from clinical texts in the past few years...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28694812/induction-of-innate-immune-memory-by-engineered-nanoparticles-a-hypothesis-that-may-become-true
#10
Paola Italiani, Diana Boraschi
Innate immune memory is the capacity of cells of the innate immune system, such as monocytes and macrophages, to react differently to an inflammatory or infectious challenge if previously exposed to the same or to another agent. Innate immune memory is a protective mechanism, based on epigenetic reprogramming, that ensures effective protection while limiting side effects of tissue damage, by controlling innate/inflammatory responses to repeated stimulations. Engineered nanoparticles (NPs) are novel challenges for our innate immune system, and their ability to induce inflammatory activation, thereby posing health risks, is currently being investigated with controversial results...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28692927/coal-emissions-adverse-human-health-effects-associated-with-ultrafine-nano-particles-role-and-resultant-engineering-controls
#11
Marcos L S Oliveira, Orlando G Navarro, Tito J Crissien, Bernardo F Tutikian, Kátia da Boit, Elba C Teixeira, Juan J Cabello, Dayana M Agudelo-Castañeda, Luis F O Silva
There are multiple elements which enable coal geochemistry: (1) boiler and pollution control system design parameters, (2) temperature of flue gas at collection point, (3) feed coal and also other fuels like petroleum coke, tires and biomass geochemistry and (4) fuel feed particle size distribution homogeneity distribution, maintenance of pulverisers, etc. Even though there is a large number of hazardous element pollutants in the coal-processing industry, investigations on micrometer and nanometer-sized particles including their aqueous colloids formation reactions and their behaviour entering the environment are relatively few in numbers...
July 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/28682155/community-health-integration-through-pharmacy-process-and-ergonomics-redesign-chipper
#12
Michelle A Jahn, Barrett S Caldwell
As the expansion and utilization of community pharmacy systems increases, so does the risk for an adverse drug event to occur. In attempts to mitigate this risk, many community pharmacies implement health information technology (IT); however, there are challenges in integrating the wider systems components necessary for a successful implementation with minimal unintended consequences. The purpose of this paper is to introduce a Community Health Integration through Pharmacy Process and Ergonomics Redesign (CHIPPER) framework, which explores the multiple angles of health IT integration to support medication delivery processes in community pharmacy systems...
July 6, 2017: Ergonomics
https://www.readbyqxmd.com/read/28678068/anesthesia-adverse-events-voluntarily-reported-in-the-veterans-health-administration-and-lessons-learned
#13
Julia Neily, Elda S Silla, Sam John T Sum-Ping, Roberta Reedy, Douglas E Paull, Lisa Mazzia, Peter D Mills, Robin R Hemphill
BACKGROUND: Anesthesia providers have long been pioneers in patient safety. Despite remarkable efforts, anesthesia errors still occur, resulting in complications, injuries, and even death. The Veterans Health Administration (VHA) National Center of Patient Safety uses root cause analysis (RCA) to examine why system-related adverse events occur and how to prevent future similar events. This study describes the types of anesthesia adverse events reported in VHA hospitals and their root causes and preventative actions...
July 1, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28675413/nano-p%C3%A3-gott-och-ont-m%C3%A3-jligheter-och-risker-med-nanoteknologi
#14
Bengt Fadeel
Engineered nanomaterials are produced for a wide range of applications, not least in medicine. Indeed, the field of nanomedicine is rapidly attaining maturity, with novel nanoscale constructs for diagnosis or therapy, or both (so-called theranostics). However, close attention should be paid to the potential environmental and human health impact of the emerging nanotechnologies. More information on human and environmental exposure is needed, along with a more detailed understanding of the hazard potential of different classes of nanomaterials...
July 4, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28666688/development-of-purple-endosperm-rice-by-engineering-anthocyanin-biosynthesis-in-the-endosperm-with-a-high-efficiency-transgene-stacking-system
#15
Qinlong Zhu, Suize Yu, Dongchang Zeng, Hongmei Liu, Huicong Wang, Zhongfang Yang, Xianrong Xie, Rongxin Shen, Jiantao Tan, Heying Li, Xiucai Zhao, Qunyu Zhang, Yuanling Chen, Jingxing Guo, Letian Chen, Yao-Guang Liu
Anthocyanins have high antioxidant activities, and engineering of anthocyanin biosynthesis in staple crops, such as rice (Oryza sativa L.), could provide health-promoting foods for improving human health. However, engineering metabolic pathways for biofortification remains difficult, and previous attempts to engineer anthocyanin production in rice endosperm failed because of the sophisticated genetic regulatory network of its biosynthetic pathway. In this study, we developed a high-efficiency vector system for transgene stacking and used it to engineer anthocyanin biosynthesis in rice endosperm...
July 5, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28659678/-never-events-in-surgery-mere-error-or-an-avoidable-disaster
#16
Jitendra Kumar, Rajni Raina
Never events in surgery is not an uncommon occurrence. It is difficult to find any surgeon who never had an experience of one or another kind of mistake, committed while delivering the surgical care to the patient. Whatever the reports come out through news media or other sources are just a tip of iceberg. Collectively, its results, not only as a huge suffering and financial burden for the patients but also its impact on the operating surgeon and sometimes to related institute, are very far reaching and extremely negative...
June 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28658972/programming-microphysiological-systems-for-children-s-health-protection
#17
T B Knudsen, B Klieforth, W Slikker
Microphysiological systems (MPS) and computer simulation models that recapitulate the underlying biology and toxicology of critical developmental transitions are emerging tools for developmental effects assessment of drugs/chemicals. Opportunities and challenges exist for their application to alternative, more public health relevant and efficient chemical toxicity testing methods. This is especially pertinent to children's health research and the evaluation of complex embryological and reproductive impacts of drug/chemical exposure...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28651191/probing-safety-of-nanoparticles-by-outlining-sea-urchin-sensing-and-signaling-cascades
#18
Andi Alijagic, Annalisa Pinsino
Among currently identified issues presenting risks and benefits to human and ocean health, engineered nanoparticles (ENP) represent a priority. Predictions of their economic and social impact appear extraordinary, but their release in the environment at an uncontrollable rate is in striking contrast with the extremely limited number of studies on environmental impact, especially on the marine environment. The sea urchin has a remarkable sensing environmental system whose function and diversity came into focus during the recent years, after sea urchin genome sequencing...
June 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28649460/pulmonary-diseases-induced-by-ambient-ultrafine-and-engineered-nanoparticles-in-twenty-first-century
#19
Tian Xia, Yifang Zhu, Lina Mu, Zuo-Feng Zhang, Sijin Liu
Air pollution is a severe threat to public health globally, affecting everyone in developed and developing countries alike. Among different air pollutants, particulate matter (PM), particularly combustion-produced fine PM (PM2.5) has been shown to play a major role in inducing various adverse health effects. Strong associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality, cardiopulmonary diseases, asthma and allergic sensitization, and lung cancer...
December 2016: National Science Review
https://www.readbyqxmd.com/read/28641999/effect-of-pharmacist-care-on-medication-adherence-and-cardiovascular-outcomes-among-patients-post-acute-coronary-syndrome-a%C3%A2-systematic-review
#20
REVIEW
Maguy Saffouh El Hajj, Myriam Jihad Jaam, Ahmed Awaisu
BACKGROUND: The impact of collaborative and multidisciplinary health care on the outcomes of care in patients with acute coronary syndromes (ACS) is well-established in the literature. However, there is lack of high quality evidence on the role of pharmacist care in this setting. OBJECTIVE: This systematic review aimed to evaluate the impact of pharmacist care on patient outcomes (readmission, mortality, emergency visits, and medication adherence) in patients with ACS at or post-discharge...
June 13, 2017: Research in Social & Administrative Pharmacy: RSAP
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