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https://www.readbyqxmd.com/read/28324236/efficient-de-novo-synthesis-of-resveratrol-by-metabolically-engineered-escherichia-coli
#1
Junjun Wu, Peng Zhou, Xia Zhang, Mingsheng Dong
Resveratrol has been the subject of numerous scientific investigations due to its health-promoting activities against a variety of diseases. However, developing feasible and efficient microbial processes remains challenging owing to the requirement of supplementing expensive phenylpropanoic precursors. Here, various metabolic engineering strategies were developed for efficient de novo biosynthesis of resveratrol. A recombinant malonate assimilation pathway from Rhizobium trifolii was introduced to increase the supply of the key precursor malonyl-CoA and simultaneously, the clustered regularly interspaced short palindromic repeats interference system was explored to down-regulate fatty acid biosynthesis pathway to inactivate the malonyl-CoA consumption pathway...
March 21, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28316432/blood-transfusion-safety-current-status-and-challenges-in-nigeria
#2
REVIEW
John C Aneke, Chide E Okocha
The attainment of blood transfusion safety in Nigeria (and probably the rest of Sub-Saharan Africa) remains an uphill task due to a number of factors, ranging from shortage of blood, poor implementation of blood transfusion guidelines, infrastructural deficits to high prevalence of transfusion-transmissible infections (TTIs), particularly hepatitis and human immune deficiency viruses. We reviewed available data on blood transfusion practices and safety in Nigeria using the PubMed, PubMed Central, Google Scholar, and African Index Medicus search engines, through a combination of word and phrases relevant to the subject...
January 2017: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/28314636/comparing-non-safety-with-safety-device-sharps-injury-incidence-data-from-two-different-occupational-surveillance-systems
#3
A H Mitchell, G B Parker, H Kanamori, W A Rutala, D J Weber
The United States Occupational Safety and Health Administration (OSHA) Bloodborne Pathogens Standard as amended by the Needlestick Safety and Prevention Act requiring the use of safety-engineered medical devices to prevent needlesticks and sharps injuries has been in place since 2001. Injury changes over time include differences between those from non-safety compared with safety-engineered medical devices. This research compares two US occupational incident surveillance systems to determine whether these data can be generalized to other facilities and other countries either with legislation in place or considering developing national policies for the prevention of sharps injuries among healthcare personnel...
February 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28301736/epigenetic-regulation-a-new-frontier-for-biomedical-engineers
#4
Zhen Chen, Shuai Li, Shankar Subramaniam, John Y-J Shyy, Shu Chien
Gene expression in mammalian cells depends on the epigenetic status of the chromatin, including DNA methylation, histone modifications, promoter-enhancer interactions, and noncoding RNA-mediated regulation. The coordinated actions of these multifaceted regulations determine cell development, cell cycle regulation, cell state and fate, and the ultimate responses in health and disease. Therefore, studies of epigenetic modulations are critical for our understanding of gene regulation mechanisms at the molecular, cellular, tissue, and organ levels...
March 6, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28300785/health-monitoring-and-evaluation-of-long-span-bridges-based-on-sensing-and-data-analysis-a-survey
#5
REVIEW
Jianting Zhou, Xiaogang Li, Runchuan Xia, Jun Yang, Hong Zhang
Aimed at the health monitoring and evaluation of bridges based on sensing technology, the monitoring contents of different structural types of long-span bridges were defined. Then, the definition, classification, selection principle, and installation requirements of the sensors were summarized. The concept was proposed that new adaptable long-life sensors could be developed by new theories and new effects. The principle and methods to select controlled sections and optimize the layout design of measuring points were illustrated...
March 16, 2017: Sensors
https://www.readbyqxmd.com/read/28299803/toxicity-of-inhaled-particulate-matter-on-the-central-nervous-system-neuroinflammation-neuropsychological-effects-and-neurodegenerative-disease
#6
REVIEW
Yan Wang, Lilin Xiong, Meng Tang
Particulate matter (PM) combined with meteorological factors cause the haze, which brings inconvenience to people's daily life and deeply endanger people's health. Accumulating literature, to date, reported that PM are closely related to cardiopulmonary disease. Outpatient visits and admissions as a result of asthma and heart attacks gradually increase with an elevated concentration of PM. Owing to its special physicochemical property, the brain could be a potential target beyond the cardiopulmonary system...
March 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28294582/pioneering-medical-advances-through-nanofluidic-implantable-technologies
#7
REVIEW
R Lyle Hood, Gold Darr Hood, Mauro Ferrari, Alessandro Grattoni
Nanofluidic implantables represent a recent advance in a broad effort for developing personalized, point-of-care medical technologies. Such systems have unprecedented potential when matched with the newest developments in robotics, microprocessing, and tissue engineering. In this review, we present their emergence in medicine within the fields of diagnostics, biosensing, therapeutics, and theranostics. Discussion includes current limitations and future directions for these systems, as commensurate advances in power density and electronic processing are continually redefining the possible...
March 10, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28294555/promise-and-peril-in-nanomedicine-the-challenges-and-needs-for-integrated-systems-biology-approaches-to-define-health-risk
#8
REVIEW
Sabina Halappanavar, Ulla Vogel, Hakan Wallin, Carole L Yauk
In the 1966s visionary film 'Fantastic Voyage' a submarine crew was shrunk to 100 nm in size and injected into the body of an injured scientist to repair his damaged brain. The movie (written by Harry Kleiner; directed by Richard Fleischer; novel by Isaac Asimov) drew attention to the potential power of engineered nanoscale structures and devices to construct, monitor, control, treat, and repair individual cells. Even more interesting was the fact that the film elegantly noted that the structure had to be miniaturized to a size that is not detected by the body's immune surveillance system, and highlighted the many physiological barriers that are encountered on the submarine's long journey to the target...
March 15, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28292840/using-brain-organoids-to-understand-zika-virus-induced-microcephaly
#9
Xuyu Qian, Ha Nam Nguyen, Fadi Jacob, Hongjun Song, Guo-Li Ming
Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain organoids engineered to mimic the developing human fetal brain have been employed to model ZIKV-induced microcephaly. Here, we discuss the advantages of brain organoids over other model systems to study development and highlight recent advances in understanding ZIKV pathophysiology and its underlying pathogenesis mechanisms...
March 15, 2017: Development
https://www.readbyqxmd.com/read/28289515/biochemical-strategies-for-the-detection-and-detoxification-of-toxic-chemicals-in-the-environment
#10
EDITORIAL
Ferdinando Febbraio
Addressing the problems related to the widespread presence of an increasing number of chemicals released into the environment by human activities represents one of the most important challenges of this century. In the last few years, to replace the high cost, in terms of time and money, of conventional technologies, the scientific community has directed considerable research towards the development both of new detection systems for the measurement of the contamination levels of chemicals in people's body fluids and tissue, as well as in the environment, and of new remediation strategies for the removal of such chemicals from the environment, as a means of the prevention of human diseases...
February 26, 2017: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28288421/evaluating-the-impact-of-ambient-benzene-vapor-concentrations-on-product-water-from-condensation-water-from-air-technology
#11
Katherine M Kinder, Christopher A Gellasch, James S Dusenbury, Thomas C Timmes, Thomas M Hughes
Globally, drinking water resources are diminishing in both quantity and quality. This situation has renewed interest in Condensation Water From Air (CWFA) technology, which utilizes water vapor in the air to produce water for both potable and non-potable purposes. However, there are currently insufficient data available to determine the relationship between air contaminants and the rate at which they are transferred from the air into CWFA untreated product water. This study implemented a novel experimental method utilizing an environmental test chamber to evaluate how air quality and temperature affects CWFA untreated product water quality in order to collect data that will inform the type of water treatment required to protect human health...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28287993/prediction-of-adverse-events-in-patients-undergoing-major-cardiovascular-procedures
#12
Bobak Mortazavi, Nihar Desai, Jing Zhang, Andreas Coppi, Frederick Warner, Harlan Krumholz, Sahand Negahban
Electronic health records (EHR) provide opportunities to leverage vast arrays of data to help prevent adverse events, improve patient outcomes, and reduce hospital costs. This work develops a postoperative complications prediction system by extracting data from the EHR and creating features. The analytic engine then provides model accuracy, calibration, feature ranking, and personalized feature responses. This allows clinicians to interpret the likelihood of an adverse event occurring, general causes for these events, and the contributing factors for each specific patient...
March 1, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28286080/electrospun-protein-nanofibers-in-healthcare-a-review
#13
REVIEW
S Babitha, Lakra Rachita, K Karthikeyan, Ekambaram Shoba, Indrakumar Janani, Balan Poornima, K Purna Sai
Electrospun nanofibers are being utilized for a wide range of healthcare applications. A plethora of natural and synthetic polymers are exploited for their ability to be electrospun and replace the complex habitat provided by the extracellular matrix for the cells. The fabrication of nanofibers can be tuned to act as a multicarrier system to deliver drugs, growth factors and health supplements etc. in a sustained manner. Owing to its pliability, nanofibers reached its heights in tissue engineering and drug delivery applications...
March 9, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28276585/electronic-case-report-forms-and-electronic-data-capture-within-clinical-trials-and-pharmacoepidemiology
#14
REVIEW
David A Rorie, Robert W V Flynn, Kerr Grieve, Alexander Doney, Isla Mackenzie, Thomas M MacDonald, Amy Rogers
AIMS: Researchers in clinical and pharmacoepidemiology fields have adopted information technology (IT) and electronic data capture, but these remain underutilised despite the benefits. This review discusses electronic case report forms and electronic data capture, specifically within pharmacoepidemiology and clinical research. METHODS: The review used PubMed and the Institute of Electrical and Electronic Engineers library (IEEE). Search terms used were agreed by the authors and documented...
March 9, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28271020/a-readability-comparison-of-anti-versus-pro-influenza-vaccination-online-messages-in-japan
#15
Tsuyoshi Okuhara, Hirono Ishikawa, Masahumi Okada, Mio Kato, Takahiro Kiuchi
Historically, anti-vaccination sentiment has existed in many populations. Mass media plays a large role in disseminating and sensationalizing vaccine objections, especially via the medium of the Internet. Based on studies of processing fluency, we assumed that anti-influenza vaccination online messages to be more readable and more fluently processed than pro-influenza vaccination online messages, which may consequently sway the opinions of some audiences. The aim of this study was to compare readability of anti- and pro-influenza vaccination online messages in Japan using a measure of readability...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28268947/design-projects-motivated-and-informed-by-the-needs-of-severely-disabled-autistic-children
#16
Steve Warren, Punit Prakash, David Thompson, Bala Natarajan, Charles Carlson, Kim Fowler, Ed Brokesh, Jack Xin, Wayne Piersel, Janine Kesterson, Steve Stoffregen
Technology can positively impact the lives of severely disabled autistic children if used to (a) gather situational awareness data regarding their health, development, and behavior and (b) assist them with learning and day-to-day activities. This paper summarizes student design projects in the Kansas State University (KSU) College of Engineering that are motivated and informed by the needs of severely disabled children at Heartspring, Wichita, KS. These efforts are supported through the National Science Foundation's General and Age-Related Disabilities Engineering (GARDE) program...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268841/amp-a-platform-for-managing-and-mining-data-in-the-treatment-of-autism-spectrum-disorder
#17
Erik Linstead, Ryan Burns, Duy Nguyen, David Tyler
We introduce AMP (Autism Management Platform), an integrated health care information system for capturing, analyzing, and managing data associated with the diagnosis and treatment of Autism Spectrum Disorder in children. AMP's mobile application simplifies the means by which parents, guardians, and clinicians can collect and share multimedia data with one another, facilitating communication and reducing data redundancy, while simplifying retrieval. Additionally, AMP provides an intelligent web interface and analytics platform which allow physicians and specialists to aggregate and mine patient data in real-time, as well as give relevant feedback to automatically learn data filtering preferences over time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264940/innovative-environments-in-health-care-where-and-how-new-approaches-to-care-are-succeeding
#18
David W Bates, Aziz Sheikh, David A Asch
Organizations seeking to create innovative environments in health care need to pay attention to a number of factors. These include making available sufficient resources, notably money and physical space, but also coordination and consultation regarding intellectual property and licensing; enabling access to engineers, software developers, and behavioral scientists; making providers and patients available to innovators; having a sufficiently long-term view; and insulating the innovation group from operational demands...
March 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28263207/common-predictors-of-nurse-reported-quality-of-care-and-patient-safety
#19
Amy Witkoski Stimpfel, Maja Djukic, Carol S Brewer, Christine T Kovner
BACKGROUND: In the era of the Patient Protection and Affordable Care Act, quality of care and patient safety in health care have never been more visible to patients or providers. Registered nurses (nurses) are key players not only in providing direct patient care but also in evaluating the quality and safety of care provided to patients and families. PURPOSE: We had the opportunity to study a unique cohort of nurses to understand more about the common predictors of nurse-reported quality of care and patient safety across acute care settings...
March 3, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28248749/medication-safety-in-two-intensive-care-units-of-a-community-teaching-hospital-after-electronic-health-record-implementation-sociotechnical-and-human-factors-engineering-considerations
#20
Pascale Carayon, Tosha B Wetterneck, Randi Cartmill, Mary Ann Blosky, Roger Brown, Peter Hoonakker, Robert Kim, Sandeep Kukreja, Mark Johnson, Bonnie L Paris, Kenneth E Wood, James M Walker
OBJECTIVE: The aim of the study was to assess the impact of Electronic Health Record (EHR) implementation on medication safety in two intensive care units (ICUs). METHODS: Using a prospective pre-post design, we assessed 1254 consecutive admissions to two ICUs before and after an EHR implementation. Each medication event was evaluated with regard to medication error (error type, medication-management stage) and impact on patient (severity of potential or actual harm)...
February 28, 2017: Journal of Patient Safety
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