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https://www.readbyqxmd.com/read/28936946/genetic-tools-for-the-enhancement-of-probiotic-properties
#1
Laura Ortiz-Velez, Robert Britton
The Lactobacillus genus is a diverse group of microorganisms, many of which are of industrial and medical relevance. Several Lactobacillus species have been used as probiotics, organisms that when present in sufficient quantities confer a health benefit to the host. A significant limitation to the mechanistic understanding of how these microbes provide health benefits to their hosts and how they can be used as therapeutic delivery systems has been the lack of genetic strategies to efficiently manipulate their genomes...
September 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28934105/an-architecture-for-on-line-measurement-of-the-tip-clearance-and-time-of-arrival-of-a-bladed-disk-of-an-aircraft-engine
#2
José Miguel Gil-García, Alejandro Solís, Gerardo Aranguren, Joseba Zubia
Safety and performance of the turbo-engine in an aircraft is directly affected by the health of its blades. In recent years, several improvements to the sensors have taken place to monitor the blades in a non-intrusive way. The parameters that are usually measured are the distance between the blade tip and the casing, and the passing time at a given point. Simultaneously, several techniques have been developed that allow for the inference-from those parameters and under certain conditions-of the amplitude and frequency of the blade vibration...
September 21, 2017: Sensors
https://www.readbyqxmd.com/read/28923324/regenerating-heart-using-a-novel-compound-and-human-wharton-jelly-mesenchymal-stem-cells
#3
Shahram Rabbani, Masoud Soleimani, Mohammad Imani, Mohammad Sahebjam, Ali Ghiaseddin, Seyed Mahdi Nassiri, Jalil Majd Ardakani, Maryam Tajik Rostami, Arash Jalali, Bahmanshir Mousanassab, Mahsa Kheradmandi, Seyed Hossein Ahmadi Tafti
BACKGROUND: Myocardial infarction is a major problem in health system and most conventional therapy is not led to restoration of the health. Stem cell therapy is a method to regenerate the heart but today appropriate cell source and scaffold selection as extracellular matrix to achieve the best effect is disputing. AIM OF THE STUDY: In this study a combination of human Wharton jelly mesenchymal stem cells (HWJMSCs) with a novel compound consisting polyethylene glycol (PEG), hyaluronic acid and chitosan is presented to heart regeneration...
April 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28918508/metabolic-engineering-of-schizosaccharomyces-pombe-to-produce-punicic-acid-a-conjugated-fatty-acid-with-nutraceutic-properties
#4
Martina Garaiova, Elzbieta Mietkiewska, Randall J Weselake, Roman Holic
Punicic acid (PuA) is a conjugated linolenic acid (C18:3Δ(9c,11t,13c)) with a wide range of nutraceutic effects with the potential to reduce the incidence of a number of health disorders including diabetes, obesity, and cancer. It is the main component of seed oil from Punica granatum and Trichosanthes kirilowii. Previously, production of relatively high levels of this unusual fatty acid in the seed oil of transgenic Arabidopsis thaliana plant was accomplished by the use of A. thaliana fad3/fae1 mutant high in linoleic acid (18:2∆(9c,12c)) and by co-expression of P...
September 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28912836/methods-for-enhancing-the-reproducibility-of-biomedical-research-findings-using-electronic-health-records
#5
REVIEW
Spiros Denaxas, Kenan Direk, Arturo Gonzalez-Izquierdo, Maria Pikoula, Aylin Cakiroglu, Jason Moore, Harry Hemingway, Liam Smeeth
BACKGROUND: The ability of external investigators to reproduce published scientific findings is critical for the evaluation and validation of biomedical research by the wider community. However, a substantial proportion of health research using electronic health records (EHR), data collected and generated during clinical care, is potentially not reproducible mainly due to the fact that the implementation details of most data preprocessing, cleaning, phenotyping and analysis approaches are not systematically made available or shared...
2017: BioData Mining
https://www.readbyqxmd.com/read/28905956/poly-cytosine-mediated-nanotags-for-sers-detection-of-hg-2
#6
Lin Qi, Mingshu Xiao, Fei Wang, Lihua Wang, Wei Ji, Tiantian Man, Ali Aldalbahi, M Naziruddin Khan, Govindasami Periyasami, Mostafizur Rahaman, Abdulaziz Alrohaili, Xiangmeng Qu, Hao Pei, Cheng Wang, Li Li
Highly sensitive and selective detection of heavy metal ions, such as Hg(2+), is of great importance because the contamination of heavy metal ions has been a serious threat to human health. Herein, we have developed poly-cytosine (polyC)-mediated surface-enhanced Raman scattering (SERS) nanotags as a sensor system for rapid, selective, and sensitive detection of Hg(2+) based on thymidine-Hg(2+)-thymidine (T-Hg(2+)-T) coordination and polyC-mediated Raman activity. The SERS nanotags exploit the mismatched T-T base pairs to capture Hg(2+) form T-Hg(2+)-T bridges, which induce the aggregation of nanotags giving rise to the drastic amplification in the SERS signals...
September 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28904269/the-effectiveness-of-specific-risk-mitigation-techniques-used-in-the-production-and-handling-of-manufactured-nanomaterials-a-systematic-review
#7
Toshihiko Myojo, Tomohisa Nagata, Jos Verbeek
Many kinds of manufactured nanomaterials (MNMs) have been developed and used as basic materials of industrial products, and they may pose health risks for workers in not only developed countries but also in developing countries. Few studies have looked at the evidence for effects of controls that mitigate the risk of exposure to MNMs. Therefore, we systematically searched the literature from the year 2000 to 2015. We included studies that compared the use of an exposure control to the situation without such a technique and those that measured the exposure to MNMs as the outcome...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28901787/medication-management-strategies-used-by-older-adults-with-heart-failure-a-systems-based-analysis
#8
Robin S Mickelson, Richard J Holden
BACKGROUND: Older adults with heart failure use strategies to cope with the constraining barriers impeding medication management. Strategies are behavioral adaptations that allow goal achievement despite these constraining conditions. When strategies do not exist, are ineffective or maladaptive, medication performance and health outcomes are at risk. While constraints to medication adherence are described in literature, strategies used by patients to manage medications are less well-described or understood...
September 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28901712/engineering-concepts-in-stem-cell-research
#9
REVIEW
Karthikeyan Narayanan, Sachin Mishra, Satnam Singh, Ming Pei, Balazs Gulyas, Parasuraman Padmanabhan
The field of regenerative medicine integrates advancements made in stem cells, molecular biology, engineering and clinical methodologies. Stem cells serve as a fundamental ingredient for therapeutic application in regenerative medicine. Apart from stem cells, engineering concepts have equally contributed to the success of stem cell based applications in improving human health. The purpose of various engineering methodologies is to develop regenerative and preventive medicine to combat various diseases and deformities...
September 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28901701/exploring-extended-scope-of-practice-in-dietetics-a-systems-approach
#10
Dominique Ryan, Fiona Pelly, Elizabeth Purcell
AIM: The aim of this study was to explore health professionals' perceptions of an extended scope of a practice clinic, and develop a framework using a systems approach to facilitate extended scope models across various health settings. METHODS: A qualitative investigation using semi-structured interviews with four health professionals involved in an extended scope dietitian-led gastroenterology clinic in a hospital in regional Queensland was conducted. A case study design was utilised to investigate interviewees' perceptions of the clinic...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28901276/immunocontraception-filamentous-bacteriophage-as-a-platform-for-vaccine-development
#11
Tatiana I Samoylova, Timothy D Braden, Jennifer A Spencer, Frank F Bartol
Population control of domestic, wild and invasive species of animals is a global issue of importance to public health, animal welfare and the economy. Although many methods for regulation of animal reproduction are available, the need for effective, safe, and inexpensive contraceptives remains. Immunocontraceptives (contraceptive vaccines) are designed to stimulate the immune system in order to block critical events in the reproductive process and suppress fertility. Platforms used for vaccine development play a critical role in vaccine efficacy, safety, and practicality...
September 11, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28901254/therapeutics-and-immunoprophylaxis-against-noroviruses-and-rotaviruses
#12
Souvik Ghosh, Yashpal Singh Malik, Nobumichi Kobayashi
Noroviruses and rotaviruses are important viral etiologies of severe gastroenteritis. Noroviruses are the primary cause of non-bacterial diarrheal outbreaks in humans, whilst rotaviruses are a major cause of childhood diarrhea. Although both enteric pathogens substantially impact human health and economies, there are no approved drugs against noroviruses and rotaviruses, so far. On the other hand, whilst the currently licensed rotavirus vaccines have been successfully implemented in over 100 countries, the most advanced norovirus vaccine has recently completed phase-I and II trials...
September 12, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28893713/next-generation-plant-metabolic-engineering-inspired-by-an-ancient-chinese-irrigation-system
#13
REVIEW
Rao Fu, Cathie Martin, Yang Zhang
Specialized secondary metabolites serve not only to protect plants against abiotic and biotic challenges, but have also been used extensively by humans to combat diseases. Due to the importance of medicinal plants for health, we need to find new and sustainable ways to produce their specialized metabolites. In addition to direct extraction, recent progress in metabolic engineering of plants offers alternative supply options. We argue that metabolic engineering for the production of some secondary metabolites in plants may have distinct advantages over microbial production platforms and we propose new approaches to plant metabolic engineering, inspired by an ancient Chinese irrigation system...
September 8, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28883681/occupational-disease-registries-characteristics-and-experiences
#14
Somayeh Davoodi, Khosro Sadeghniat Haghighi, Sharareh Rostam Niakan Kalhori, Narges Shams Hosseini, Zeinab Mohammadzadeh, Reza Safdari
INTRODUCTION: Due to growth of occupational diseases and also increase of public awareness about their consequences, attention to various aspects of diseases and improve occupational health and safety has found great importance. Therefore, there is the need for appropriate information management tools such as registries in order to recognitions of diseases patterns and then making decision about prevention, early detection and treatment of them. These registries have different characteristics in various countries according to their occupational health priorities...
June 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28882782/prostate-cancer-in-transgender-women-incidence-etiopathogenesis-and-management-challenges
#15
Nicholas A Deebel, Jacqueline P Morin, Riccardo Autorino, Randy Vince, Baruch Grob, Lance J Hampton
OBJECTIVES: To critically analyze the available evidence regarding the incidence, etiopathogenesis, and management of CaP in this specific subset of patients. In addition, this manuscript aims to present a recent case report of a transgender woman with a unique presentation at the author's institution. METHODS: An electronic non-systematic literature search was performed to identify pertinent studies. PubMed search engine was queried by using the following search terms: "prostate cancer", "male to female transsexual", "transgender patient", "androgen+prostate cancer", "estrogen therapy+prostate cancer", "health care barrier"...
September 4, 2017: Urology
https://www.readbyqxmd.com/read/28882733/-risk-of-fatal-non-fatal-events-in-patients-with-previous-coronary-heart-disease-acute-myocardial-infarction-and-treatment-with-non-steroidal-anti-inflammatory-drugs
#16
REVIEW
L Muñoz Olmo, J Juan Armas, J J Gomariz García
BACKGROUND: Primary Care is the fundamental axis of our health system and obliges us to be consistent with our prescriptions. The non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with increased cardiovascular risk and increased risk of all causes of death, as well as acute myocardial infarction (AMI) in patients with a previous myocardial infarction. Pain and cardiac patient management are 2 basic pillars in our daily activity, and we must know the limitations of NSAIDs in patients with established cardiovascular risk...
September 4, 2017: Semergen
https://www.readbyqxmd.com/read/28880573/bacteriocins-as-food-preservatives-challenges-and-emerging-horizons
#17
Eldin Maliyakkal Johnson, Dr Yong-Gyun Jung, Dr Ying-Yu Jin, Dr Rasu Jayabalan, Dr Seung Hwan Yang, Joo Won Suh
The increasing demand for fresh-like food products and the potential health hazards of chemically preserved and processed food products have led to the advent of alternative technologies for the preservation and maintenance of the freshness of the food products. One such preservation strategy is the usage of bacteriocins or bacteriocins producing starter cultures for the preservation of the intended food matrixes. Bacteriocins are ribosomally synthesized smaller polypeptide molecules that exert antagonistic activity against closely related and unrelated group of bacteria...
September 7, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28877692/the-use-of-a-p-falciparum-specific-coiled-coil-domain-to-construct-a-self-assembling-protein-nanoparticle-vaccine-to-prevent-malaria
#18
Christopher P Karch, Tais A P F Doll, Sara M Paulillo, Issa Nebie, David E Lanar, Giampietro Corradin, Peter Burkhard
BACKGROUND: The parasitic disease malaria remains a major global public health concern and no truly effective vaccine exists. One approach to the development of a malaria vaccine is to target the asexual blood stage that results in clinical symptoms. Most attempts have failed. New antigens such as P27A and P27 have emerged as potential new vaccine candidates. Multiple studies have demonstrated that antigens are more immunogenic and are better correlated with protection when presented on particulate delivery systems...
September 6, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28875056/blogs-as-channels-for-disseminating-health-technology-innovations
#19
Ashish Joshi, Rinzin Wangmo, Chioma Amadi
OBJECTIVES: The objective of this study was to describe the features of health informatics blogs on the Internet. METHODS: A search was conducted in August, 2016 using the search engine, Google, and key words: 'mobile health blog,' 'telehealth/telemedicine blog,' 'Electronic Health Record blog,' 'personalized health record blog,' 'population health decision support system blog,' and 'public/population health dashboard blog.' The first 24 blogs resulting from each key word search were recorded, generating 144 blogs...
July 2017: Healthcare Informatics Research
https://www.readbyqxmd.com/read/28869063/nanoparticles-and-innate-immunity-new-perspectives-on-host-defence
#20
REVIEW
Diana Boraschi, Paola Italiani, Roberto Palomba, Paolo Decuzzi, Albert Duschl, Bengt Fadeel, S Moein Moghimi
The innate immune system provides the first line of defence against foreign microbes and particulate materials. Engineered nanoparticles can interact with the immune system in many different ways. Nanoparticles may thus elicit inflammation with engagement of neutrophils, macrophages and other effector cells; however, it is important to distinguish between acute and chronic inflammation in order to identify the potential hazards of nanoparticles for human health. Nanoparticles may also interact with and become internalised by dendritic cells, key antigen-presenting cells of the immune system, where a better understanding of these processes could pave the way for improved vaccination strategies...
August 28, 2017: Seminars in Immunology
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